Identifier | PITRANSFER  [View Relations]  [View Alignment]  
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Accession | PR00391 |
No. of Motifs | 5 |
Creation Date | 03-JUL-1995  (UPDATE 07-JUN-1999) |
Title | Phosphatidylinositol transfer protein signature |
Database References | INTERPRO; IPR001666
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Literature References | 1. LISCOVITCH, M. AND CANTLEY, L.C.
Signal transduction and membrane traffic: the PITP/phosphoinositide
connection.
CELL 81 659-662 (1995).
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Documentation | Phosphatidylinositol transfer protein (PITP) is a ubiquitous cytosolic
protein, thought to be involved in transport of phospholipids from their
site of synthesis in the endoplasmic reticulum and Golgi to other cell
membranes [1]. More recently, PITP has been shown to be an essential
component of the polyphosphoinositide synthesis machinery and is hence
required for proper signalling by epidermal growth factor and f-Met-Leu-Phe,
as well as for exocytosis. The role of PITP in polyphosphoinositide
synthesis may also explain its involvement in intracellular vesicular
traffic [1].
PITRANSFER is a 5-element fingerprint that provides a signature for
phosphatidylinositol transfer proteins. The fingerprint was derived from
an initial alignment of 4 sequences: the motifs were drawn from conserved
regions spanning the full alignment length. Two iterations on OWL26.0
were required to reach convergence, at which point a true set comprising
7 sequences was identified.
An update on SPTR37_9f identified a true set of 12 sequences.
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Summary Information | 12 codes involving 5 elements 0 codes involving 4 elements 0 codes involving 3 elements 0 codes involving 2 elements
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Composite Feature Index | 5 | 12 | 12 | 12 | 12 | 12 | 4 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | | 1 | 2 | 3 | 4 | 5 |
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True Positives | O00562 O02434 O35954 O62119 PPI1_HUMAN PPI1_MOUSE PPI1_RABIT PPI1_RAT PPI2_HUMAN PPI2_MOUSE PPI2_RAT RDGB_DROME |
Sequence Titles | O00562 HOMOLOGUE OF DROSPHILA RETINAL DEGENERATION B GENE - HOMO SAPIENS (HUMAN). O02434 RETINAL DEGENERATION B PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY). O35954 PHOSPHATIDYLINOSITOL MEMBRANE-ASSOCIATED (MEMBRANE-ASSOCIATED PHOSPHATIDYLINOSITOL TRANSFER PROTEIN) - MUS MUSCULUS (MOUSE). O62119 M01F1.7 PROTEIN - CAENORHABDITIS ELEGANS. PPI1_HUMAN PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM (PTDINS TRANSFER PROTEIN ALPHA) (PTDINSTP) (PI-TP-ALPHA) - HOMO SAPIENS (HUMAN). PPI1_MOUSE PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM (PTDINS TRANSFER PROTEIN ALPHA) (PTDINSTP) (PI-TP-ALPHA) - MUS MUSCULUS (MOUSE). PPI1_RABIT PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM (PTDINS TRANSFER PROTEIN ALPHA) (PTDINSTP) (PI-TP-ALPHA) - ORYCTOLAGUS CUNICULUS (RABBIT). PPI1_RAT PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM (PTDINS TRANSFER PROTEIN ALPHA) (PTDINSTP) (PI-TP-ALPHA) - RATTUS NORVEGICUS (RAT). PPI2_HUMAN PHOSPHATIDYLINOSITOL TRANSFER PROTEIN BETA ISOFORM (PTDINS TRANSFER PROTEIN BETA) (PTDINSTP) (PI-TP-BETA) - HOMO SAPIENS (HUMAN). PPI2_MOUSE PHOSPHATIDYLINOSITOL TRANSFER PROTEIN BETA ISOFORM (PTDINS TRANSFER PROTEIN BETA) (PTDINSTP) (PI-TP-BETA) - MUS MUSCULUS (MOUSE). PPI2_RAT PHOSPHATIDYLINOSITOL TRANSFER PROTEIN BETA ISOFORM (PTDINS TRANSFER PROTEIN BETA) (PTDINSTP) (PI-TP-BETA) - RATTUS NORVEGICUS (RAT). RDGB_DROME RETINAL DEGENERATION B PROTEIN (PROBABLE CALCIUM TRANSPORTER RDGB) - DROSOPHILA MELANOGASTER (FRUIT FLY).
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Scan History | OWL26_0 2 100 NSINGLE SPTR37_9f 2 13 NSINGLE
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Initial Motifs | Motif 1 width=20 Element Seqn Id St Int Rpt EYQVGQLYSVAEASKNETGG PPIT_HUMAN 16 16 - EYQVGQLYSVAEASKNETGG PPIT_RAT 16 16 - EYQVGQLYSVAEASKNETGG A48214 9 9 - EYQVGQLYSVAEASKNETGG JX0316 17 17 - Motif 2 width=21 Element Seqn Id St Int Rpt HEKAWNAYPYCRTVITNEYMK PPIT_HUMAN 83 47 - HEKAWNAYPYCRTVITNEYMK PPIT_RAT 84 48 - HEKAWNAYPYCRTVITNEYMK A48214 54 25 - HEKAWNAYPYCRTIVTNEYMK JX0316 84 47 - Motif 3 width=16 Element Seqn Id St Int Rpt IETWHKPDLGTQENVH PPIT_HUMAN 110 6 - IETWHKPDLGTQENVH PPIT_RAT 111 6 - IETWHKPDLGTLENVH A48214 75 0 - IETWHKPDLGTLENVH JX0316 111 6 - Motif 4 width=16 Element Seqn Id St Int Rpt FKWWGLQNKVENFIHK PPIT_HUMAN 199 73 - FKWWGLQNKVENFIHK PPIT_RAT 200 73 - FKWWGLQNKVENFIHK A48214 121 30 - FKWWGLQSKVENFIQK JX0316 200 73 - Motif 5 width=20 Element Seqn Id St Int Rpt LFTNFHRQLFCWLDKWVDLT PPIT_HUMAN 219 4 - LFTNFHRQLFCWLDKWVDLT PPIT_RAT 220 4 - LFTNFHRQLFCWLDKWVDLT A48214 137 0 - IFTNLHRQLFCWIDKWIDLT JX0316 220 4 -
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Final Motifs | Motif 1 width=20 Element Seqn Id St Int Rpt EYQVGQLYSVAEASKNETGG PPI1_HUMAN 16 16 - EYQVGQLYSVAEASKNETGG PPI1_RAT 16 16 - EYQVGQLYSVAEASKNETGG PPI1_RABIT 16 16 - EYQVGQLYSVAEASKNETGG PPI1_MOUSE 16 16 - EYQVGQLYSVAEASKNETGG PPI2_HUMAN 16 16 - EYQVGQLYSVAEASKNETGG PPI2_MOUSE 16 16 - EYQVGQLYSVAEASKNETGG PPI2_RAT 16 16 - EYQVAQLYMIQKKSREESSG O35954 16 16 - EYQVAQLYMIQKKSREESSG O00562 16 16 - EYRIAQLYMIAKKSREESHG O02434 16 16 - EYRIAQLYMIAKKSREESHG RDGB_DROME 16 16 - EYRIAQLYMIQKKSRLDSHG O62119 16 16 - Motif 2 width=21 Element Seqn Id St Int Rpt HEKAWNAYPYCRTVITNEYMK PPI1_HUMAN 83 47 - HEKAWNAYPYCRTVITNEYMK PPI1_RAT 84 48 - HEKAWNAYPYCRTVITNEYMK PPI1_RABIT 83 47 - HEKAWNAYPYCRTVITNEYMK PPI1_MOUSE 84 48 - HEKAWNAYPYCRTIVTNEYMK PPI2_HUMAN 83 47 - HEKAWNAYPYCRTIVTNEYMK PPI2_MOUSE 83 47 - HEKAWNAYPYCRTIVTNEYMK PPI2_RAT 83 47 - EEESWNAYPYTRTRYTCPFVE O35954 85 49 - EEESWNAYPYTRTRYTCPFVE O00562 85 49 - EEEAMECYPYTRTRYTCPFVE O02434 85 49 - EEEAMECYPYTRTRYTCPFVE RDGB_DROME 85 49 - HEESWNAYPVTKTRYSTPMMD O62119 85 49 - Motif 3 width=16 Element Seqn Id St Int Rpt IETWHKPDLGTQENVH PPI1_HUMAN 110 6 - IETWHKPDLGTQENVH PPI1_RAT 111 6 - IETWHKPDLGTQENVH PPI1_RABIT 110 6 - IETWHKPDLGTQENVH PPI1_MOUSE 111 6 - IETWHKPDLGTLENVH PPI2_HUMAN 110 6 - IETWHKPDLGTLENVH PPI2_MOUSE 110 6 - IETWHKPDLGTLENVH PPI2_RAT 110 6 - IETYYLPDGGQQPNVF O35954 111 5 - IETYYLPDGGQQPNVF O00562 111 5 - IETYYYPDNGYQDNVF O02434 111 5 - IETYYYPDNGYQDNVF RDGB_DROME 111 5 - VETLYFDDHGQQENVF O62119 111 5 - Motif 4 width=16 Element Seqn Id St Int Rpt FKWWGLQNKVENFIHK PPI1_HUMAN 199 73 - FKWWGLQNKVENFIHK PPI1_RAT 200 73 - FKWWGLQNKVENFIHK PPI1_RABIT 199 73 - FKWWGLQNKVENFIHK PPI1_MOUSE 200 73 - FKWWGLQSKVENFIQK PPI2_HUMAN 199 73 - FKWWGLQSKVENFIQK PPI2_MOUSE 199 73 - FKWWGLQSKVENFIQK PPI2_RAT 199 73 - FRYWGMQAKIEQFIHD O35954 197 70 - FRYWGMQAKIEQFIHD O00562 197 70 - FRYWGMQTKLEKFIHD O02434 208 81 - FRYWGMQTKLEKFIHD RDGB_DROME 208 81 - FRYWGMQTRAERWIHD O62119 198 71 - Motif 5 width=20 Element Seqn Id St Int Rpt LFTNFHRQLFCWLDKWVDLT PPI1_HUMAN 219 4 - LFTNFHRQLFCWLDKWVDLT PPI1_RAT 220 4 - LFTNFHRQLFCWLDKWVDLT PPI1_RABIT 219 4 - LFTNFHRQLFCWLDKWVDLT PPI1_MOUSE 220 4 - IFTNFHRQLFCWIDKWIDLT PPI2_HUMAN 219 4 - IFTNLHRQLFCWIDKWIDLT PPI2_MOUSE 219 4 - IFTNLHRQLFCWIDKWIDLT PPI2_RAT 219 4 - VMLRAHRQAWCWQDEWIELS O35954 218 5 - VMLRAHRQAWCWQDEWTELS O00562 218 5 - MMLRAHRQAWAWQDEWFGLT O02434 229 5 - MMLRAHRQAWAWQDEWFGLT RDGB_DROME 229 5 - TMMRAHRQAWAWQDEWTGLT O62119 219 5 -
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