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PR00383

Identifier
MELANOCORTIN  [View Relations]  [View Alignment]  
Accession
PR00383
No. of Motifs
5
Creation Date
04-JUL-1995  (UPDATE 10-JUN-1999)
Title
Pro-opiomelanocortin signature
Database References

PFAM; PF00976 ACTH_domain
INTERPRO; IPR001941
Literature References
1. WATSON, S. AND ARKINSTALL, S.
Melanocortins.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.188-191.

Documentation
Pro-opiomelanocortin is present in high levels in the pituitary and is
processed into 3 major peptide families: adrenocorticotrophin (ACTH);
alpha-, beta- and gamma-melanocyte-stimulating hormones (MSH); and
beta-endorphin [1]. ACTH regulates the synthesis and release of gluco-
corticoids and, to some extent, aldosterone in the adrenal cortex. It is
synthesised and released in response to corticotrophin-releasing factor
at times of stress (i.e. heat, cold, infection, etc.), its release leading
to increased metabolism. The action of MSH in man is poorly understood,
but it may be involved in temperature regulation [1]. Full activity of ACTH
resides in the first 20 N-terminal amino acids, the first 13 of which are
identical to alpha-MSH.  
 
MELANOCORTIN is a 5-element fingerprint that provides a signature for the
pro-opiomelanocortins. The fingerprint was derived from an initial
alignment of 4 sequences: motifs 1-3 span the ACTH peptide, while motifs
4 and 5 were drawn from the beta-MSH peptide. Three iterations on OWL26.0
were required to reach convergence, at which point a true set comprising
20 sequences was identified. Several partial matches were also found, all
of which are cleavage products of pro-opiomelanocortin.
 
An update on SPTR37_9f identified a true set of 16 sequences, and 8
partial matches.
Summary Information
  16 codes involving  5 elements
1 codes involving 4 elements
3 codes involving 3 elements
4 codes involving 2 elements
Composite Feature Index
51616161616
411011
333300
241003
12345
True Positives
COLI_ACITR    COLI_BOVIN    COLI_CAVPO    COLI_HUMAN    
COLI_MACNE COLI_MOUSE COLI_ONCKE COLI_ONCMY
COLI_PIG COLI_RANCA COLI_RANRI COLI_RAT
COLI_XENLA COLJ_ONCMY COLJ_XENLA Q91082
True Positive Partials
Codes involving 4 elements
O93261
Codes involving 3 elements
COLI_BALPH COLI_RABIT COLI_STRCA
Codes involving 2 elements
COLI_SQUAC Q91256 Q91258 Q91259
Sequence Titles
COLI_ACITR  CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - ACIPENSER TRANSMONTANUS (WHITE STURGEON). 
COLI_BOVIN CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: NPP; MELANOTROPIN GAMMA (GAMMA-MSH); CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP); LIPOTROPIN BETA (BETA- LPH); LIPOTROPIN GAMMA (GAMMA-LPH); MELANOTROPIN BETA (BETA-MSH); BETA-ENDORPHIN; MET-ENKEPHALIN] - BOS TAURUS (BOVINE).
COLI_CAVPO CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: NPP; MELANOTROPIN GAMMA (GAMMA-MSH); CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP); LIPOTROPIN BETA (BETA- LPH); LIPOTROPIN GAMMA (GAMMA-LPH); MELANOTROPIN BETA (BETA-MSH); BETA-ENDORPHIN; MET-ENKEPHALIN] - CAVIA PORCELLUS (GUINEA PIG).
COLI_HUMAN CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: NPP; MELANOTROPIN GAMMA (GAMMA-MSH); CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP); LIPOTROPIN BETA (BETA- LPH); LIPOTROPIN GAMMA (GAMMA-LPH); MELANOTROPIN BETA (BETA-MSH); BETA-ENDORPHIN; MET-ENKEPHALIN] - HOMO SAPIENS (HUMAN).
COLI_MACNE CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: NPP; MELANOTROPIN GAMMA (GAMMA-MSH); CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP); LIPOTROPIN BETA (BETA- LPH); LIPOTROPIN GAMMA (GAMMA-LPH); MELANOTROPIN BETA (BETA-MSH); BETA-ENDORPHIN; MET-ENKEPHALIN] - MACACA NEMESTRINA (PIG-TAILED MACAQUE).
COLI_MOUSE CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: NPP; MELANOTROPIN GAMMA (GAMMA-MSH); CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP); LIPOTROPIN BETA (BETA- LPH); LIPOTROPIN GAMMA (GAMMA-LPH); MELANOTROPIN BETA (BETA-MSH); BETA-ENDORPHIN; MET-ENKEPHALIN] - MUS MUSCULUS (MOUSE).
COLI_ONCKE CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - ONCORHYNCHUS KETA (CHUM SALMON).
COLI_ONCMY CORTICOTROPIN-LIPOTROPIN A PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
COLI_PIG CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: NPP; MELANOTROPIN GAMMA (GAMMA-MSH); CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP); LIPOTROPIN BETA (BETA- LPH); LIPOTROPIN GAMMA (GAMMA-LPH); MELANOTROPIN BETA (BETA-MSH); BETA-ENDORPHIN; MET-ENKEPHALIN] - SUS SCROFA (PIG).
COLI_RANCA CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - RANA CATESBEIANA (BULL FROG).
COLI_RANRI CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - RANA RIDIBUNDA (LAUGHING FROG) (MARSH FROG).
COLI_RAT CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: NPP; MELANOTROPIN GAMMA (GAMMA-MSH); CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP); LIPOTROPIN BETA (BETA- LPH); LIPOTROPIN GAMMA (GAMMA-LPH); MELANOTROPIN BETA (BETA-MSH); BETA-ENDORPHIN; MET-ENKEPHALIN] - RATTUS NORVEGICUS (RAT).
COLI_XENLA CORTICOTROPIN-LIPOTROPIN A PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
COLJ_ONCMY CORTICOTROPIN-LIPOTROPIN B PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
COLJ_XENLA CORTICOTROPIN-LIPOTROPIN B PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q91082 CORTICOTROPIN-LIPOTROPIN PRECURSOR (PRO-OPIOMELANOCORTIN) (POMC) - LEPISOSTEUS OSSEUS (LONG-NOSED GAR).

O93261 PROOPIOMELANOCORTIN PRECURSOR - PROTOPTERUS ANNECTENS.

COLI_BALPH CORTICOTROPIN-LIPOTROPIN (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP)] (FRAGMENT) - BALAENOPTERA PHYSALUS (FINBACK WHALE) (COMMON RORQUAL), AND BALAENOPTERA BOREALIS (SEI WHALE).
COLI_RABIT CORTICOTROPIN-LIPOTROPIN (PRO-OPIOMELANOCORTIN) (POMC) [CONTAINS: CORTICOTROPIN (ADRENOCORTICOTROPIC HORMONE) (ACTH); MELANOTROPIN ALPHA (ALPHA-MSH); CORTICOTROPIN-LIKE INTERMEDIARY PEPTIDE (CLIP)] (FRAGMENT) - ORYCTOLAGUS CUNICULUS (RABBIT).
COLI_STRCA CORTICOTROPIN (ACTH) - STRUTHIO CAMELUS (OSTRICH).

COLI_SQUAC CORTICOTROPIN (ACTH) - SQUALUS ACANTHIAS (SPINY DOGFISH).
Q91256 PROOPIOMELANOCORTIN PRECURSOR - PETROMYZON MARINUS (SEA LAMPREY).
Q91258 PROOPIOCORTIN(POC) PRECURSOR - PETROMYZON MARINUS (SEA LAMPREY).
Q91259 PROOPIOMELANOTROPIN(POM) PRECURSOR - PETROMYZON MARINUS (SEA LAMPREY).
Scan History
OWL26_0    3  100  NSINGLE    
SPTR37_9f 2 41 NSINGLE
Initial Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
YSMEHFRWGKP COLI_HUMAN 139 139 -
YSMEHFRWGKP COLI_BOVIN 133 133 -
YSMEHFRWGKP COLI_PIG 137 137 -
YSMEHFRWGKP COLJ_ONCMY 113 113 -

Motif 2 width=16
Element Seqn Id St Int Rpt
VGKKRRPVKVYPNGAE COLI_HUMAN 150 0 -
VGKKRRPVKVYPNGAE COLI_BOVIN 144 0 -
VGKKRRPVKVYPNGAE COLI_PIG 148 0 -
IGHKRRPIKVYASSLE COLJ_ONCMY 124 0 -

Motif 3 width=10
Element Seqn Id St Int Rpt
DESAEAFPLE COLI_HUMAN 166 0 -
DESAQAFPLE COLI_BOVIN 160 0 -
DELAEAFPLE COLI_PIG 164 0 -
DSSEGTFPLQ COLJ_ONCMY 142 2 -

Motif 4 width=16
Element Seqn Id St Int Rpt
AEKKDEGPYRMEHFRW COLI_HUMAN 213 37 -
AEKKDSGPYKMEHFRW COLI_BOVIN 211 41 -
AEKKDEGPYKMEHFRW COLI_PIG 213 39 -
LQDKKDGSYRMGHFRW COLJ_ONCMY 188 36 -

Motif 5 width=14
Element Seqn Id St Int Rpt
WGSPPKDKRYGGFM COLI_HUMAN 228 -1 -
WGSPPKDKRYGGFM COLI_BOVIN 226 -1 -
WGSPPKDKRYGGFM COLI_PIG 228 -1 -
WGSPTAIKRYGGFM COLJ_ONCMY 203 -1 -
Final Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
YSMEHFRWGKP COLI_HUMAN 139 139 -
YSMEHFRWGKP COLI_MACNE 136 136 -
YSMEHFRWGKP COLI_BOVIN 133 133 -
YSMEHFRWGKP COLI_PIG 137 137 -
YSMEHFRWGKP COLI_CAVPO 126 126 -
YSMEHFRWGKP COLJ_XENLA 142 142 -
YSMEHFRWGKP COLI_RAT 125 125 -
YSMEHFRWGKP COLI_MOUSE 125 125 -
YSMEHFRWGKP Q91082 136 136 -
YSMEHFRWGKP COLI_XENLA 141 141 -
YSMEHFRWGKP COLI_ACITR 141 141 -
YSMEHFRWGKP COLI_ONCMY 105 105 -
YSMEHFRWGKP COLI_RANRI 142 142 -
YSMEHFRWGKP COLI_RANCA 145 145 -
YSMEHFRWGKP COLI_ONCKE 99 99 -
YSMEHFRWGKP COLJ_ONCMY 113 113 -

Motif 2 width=16
Element Seqn Id St Int Rpt
VGKKRRPVKVYPNGAE COLI_HUMAN 150 0 -
VGKKRRPVKVYPNGAE COLI_MACNE 147 0 -
VGKKRRPVKVYPNGAE COLI_BOVIN 144 0 -
VGKKRRPVKVYPNGAE COLI_PIG 148 0 -
VGKKRRPVKVYANGAE COLI_CAVPO 137 0 -
VGRKRRPIKVYPNGVE COLJ_XENLA 153 0 -
VGKKRRPVKVYPNVAE COLI_RAT 136 0 -
VGKKRRPVKVYPNVAE COLI_MOUSE 136 0 -
VGRKRRPVKVYPNGVE Q91082 147 0 -
VGRKRRPIKVYPNGVE COLI_XENLA 152 0 -
VGRKRRPVKVYPNGVE COLI_ACITR 152 0 -
VGRKRRPVKVYTNGVE COLI_ONCMY 116 0 -
VGKKRRPIKVFPTDAE COLI_RANRI 153 0 -
VGKKRRPIKVFPTDAE COLI_RANCA 156 0 -
IGHKRRPIKVYASSLE COLI_ONCKE 110 0 -
IGHKRRPIKVYASSLE COLJ_ONCMY 124 0 -

Motif 3 width=10
Element Seqn Id St Int Rpt
DESAEAFPLE COLI_HUMAN 166 0 -
DESAEAFPLE COLI_MACNE 163 0 -
DESAQAFPLE COLI_BOVIN 160 0 -
DELAEAFPLE COLI_PIG 164 0 -
EESAEAFPLE COLI_CAVPO 153 0 -
EESAESFPME COLJ_XENLA 169 0 -
NESAEAFPLE COLI_RAT 152 0 -
NESAEAFPLE COLI_MOUSE 152 0 -
EESAEAYPTE Q91082 163 0 -
EESAESYPME COLI_XENLA 168 0 -
EESAESYPAE COLI_ACITR 168 0 -
EESSEAFPSE COLI_ONCMY 132 0 -
EESSEIFPLE COLI_RANRI 169 0 -
EESSESFPIE COLI_RANCA 172 0 -
DSSEGTFPLQ COLI_ONCKE 128 2 -
DSSEGTFPLQ COLJ_ONCMY 142 2 -

Motif 4 width=16
Element Seqn Id St Int Rpt
AEKKDEGPYRMEHFRW COLI_HUMAN 213 37 -
AEKKDEGPYRMEHFRW COLI_MACNE 210 37 -
AEKKDSGPYKMEHFRW COLI_BOVIN 211 41 -
AEKKDEGPYKMEHFRW COLI_PIG 213 39 -
AEKKDDGSYRMEHFRW COLI_CAVPO 202 39 -
ALTKKNGNYRMHHFRW COLJ_XENLA 206 27 -
DTEKADGPYRVEHFRW COLI_RAT 181 19 -
DAEKDDGPYRVEHFRW COLI_MOUSE 181 19 -
LQEKKDGSYKMHHFRW Q91082 202 29 -
ALTKKNGNYRMHHFRW COLI_XENLA 205 27 -
NLQKKDGSYKMNHFRW COLI_ACITR 206 28 -
LQEKKDGSYKMNHFRW COLI_ONCMY 175 33 -
GPVKKDRKYKMHHFRW COLI_RANRI 206 27 -
GPVKKGRKYKMHHFRW COLI_RANCA 209 27 -
LQDKKDGSYRMGHFRW COLI_ONCKE 174 36 -
LQDKKDGSYRMGHFRW COLJ_ONCMY 188 36 -

Motif 5 width=14
Element Seqn Id St Int Rpt
WGSPPKDKRYGGFM COLI_HUMAN 228 -1 -
WGSPPKDKRYGGFM COLI_MACNE 225 -1 -
WGSPPKDKRYGGFM COLI_BOVIN 226 -1 -
WGSPPKDKRYGGFM COLI_PIG 228 -1 -
WGTPRKGKRYGGFM COLI_CAVPO 217 -1 -
WGSPPKDKRYGGFM COLJ_XENLA 221 -1 -
WGNPPKDKRYGGFM COLI_RAT 196 -1 -
WSNPPKDKRYGGFM COLI_MOUSE 196 -1 -
WSRPPKDKRYGGFM Q91082 217 -1 -
WGSPPKDKRYGGFM COLI_XENLA 220 -1 -
WSGPPKDKRYGGFM COLI_ACITR 221 -1 -
WSGPPASKRYGGFM COLI_ONCMY 190 -1 -
WEGPPKDKRYGGFM COLI_RANRI 221 -1 -
WEGPPKDKRYGGFM COLI_RANCA 224 -1 -
WGSPTAIKRYGGFM COLI_ONCKE 189 -1 -
WGSPTAIKRYGGFM COLJ_ONCMY 203 -1 -