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PR00378

Identifier
LIIMPHPHTASE  [View Relations]  [View Alignment]  
Accession
PR00378
No. of Motifs
5
Creation Date
03-JUL-1995  (UPDATE 03-FEB-2009)
Title
Lithium-sensitive myo-inositol monophosphatase family signature
Database References
PRINTS; PR00377 IMPHPHTASES
PROSITE; PS00629 IMP_1; PS00630 IMP_2
PFAM; PF00459 inositol_P
PRODOM; PD023420
INTERPRO; IPR000760
PDB; 2QFL; 2HHM
SCOP; 2QFL; 2HHM
CATH; 2QFL; 2HHM
Literature References
1. YORK, J.D., PONDER, J.W. AND MAJERUS, P.W.
Definition of a metal-dependent/Li+-inhibited phosphomonoesterase
protein family based upon a conserved three-dimensional core structure.
PROC.NATL.ACAD.SCI.U.S.A. 92 5149-5153 (1995).
 
2. BERRIDGE, M.J., DOWNES, C.P. AND HANLEY, M.R.
Neural and developmental actions of lithium - a unifying hypothesis.
CELL 59 411-419 (1989).
 
3. GILL, R., MOHAMMED, F., BADYAL, R., COATES, L., ERSKINE, P., THOMPSON, D., 
COOPER, J., GORE, M. AND WOOD, S. 
High-resolution structure of myo-inositol monophosphatase, the putative
target of lithium therapy. 
ACTA CRYSTALLOGR.D 61 545-555 (2005). 
 
4. SJOHOLT, G., GULBRANDSEN, A.K., LOVLIE, R., BERLE, J., MOLVEN, A. AND
STEEN, V.M. 
A human myo-inositol monophosphatase gene (IMPA2) localized in a putative 
susceptibility region for bipolar disorder on chromosome 18p11.2: genomic 
structure and polymorphism screening in manic- depressive patients. 
MOL.PSYCHIATRY 5 172-180 (2000). 
 
5. GANZHORN, A.J., RONDEAU, J.-M. 
Structure of an enzyme-substrate complex and the catalytic mechanism of
human brain myo-inositol monophosphatase. 
PROTEIN ENG. 10 61-70 (1997). 
 
6. BONE, R., FRANK, L., SPRINGER, J.P. AND ATACK, J.R. 
Structural studies of metal binding by inositol monophosphatase: evidence
for two-metal ion catalysis. 
BIOCHEMISTRY 33 9468-9476 (1994). 
 
7. ZHANG, Y., LIANG, J.-Y. AND LIPSCOMB, W.N.
Structural similarities between fructose 1,6-bisphosphatase and 
inositol monophosphatase.
BIOCHEM.BIOPHYS.RES.COMMUN. 190(3) 1080-1083 (1993).
 
8. TANIZAWA, Y., KUHARA, A., INADA, H., KODAMA, E., MIZUNO, T. AND MORI, I. 
Inositol monophosphatase regulates localization of synaptic components and 
behavior in the mature nervous system of C. elegans. 
GENES DEV. 20 3296-3310 (2006). 
 
9. SHAMIR, A., SJOHOLT, G., EBSTEIN, R.P., AGAM, G. AND STEEN, V.M. 
Characterization of two genes, Impa1 and Impa2 encoding mouse myo- inositol 
monophosphatases. 
GENE 271 285-291 (2001). 

Documentation
Inositol polyphosphate 1-phosphatase (1PTASE) and inositol monophosphatase
(MPTASE) are enzymes of the inositol signalling pathway that share similar
enzymatic activity [1]. Both enzymes exhibit an absolute requirement for
metal ions (Mg2+ is preferred), and both are uncompetitively inhibited by
submillimolar concentrations of Li+. Their amino acid sequences contain
a number of conserved motifs, which are also shared by several other 
proteins related to MPTASE (including products of fungal QaX and qutG,
bacterial suhB and cysQ, and yeast hal2) [1]. 
 
Structural analysis of these proteins has revealed a common core of 155
residues: the core comprises 5 alpha-helices and 11 beta-strands, and
includes residues essential for metal binding and catalysis. While the
core has been conserved presumably to impart catalytic function, the
loops and regions of structure outside the core have evolved unique
regulatory domains [1].  
 
An interesting property of the enzymes of this family is their sensitivity
to Li+ at levels achieved in patients undergoing therapy for manic
depression. The targets and mechanism of action of Li+ are unknown, but
overactive inositol phosphate signalling may account for symptoms of the
disease [2,3]. It has been proposed that these Li+-sensitive proteins 
could represent targets for Li+ in manic depressive disease [1,3,4].   
 
The structures of several members of the superfamily have been determined
by X-ray crystallography [3,5,6]. The fold of fructose 1,6-bisphosphatase
(FBPTASE) was noted to be identical to that of MPTASE [7]. The lithium-
sensitive myo-inositol monophosphatases are responsible for providing the
inositol required for synthesis of phosphatidylinositol and polyphospho-
inositides; they are also required in central interneurons of the mature
nervous system for correct localisation of synaptic components [8,9].
 
LIIMPHPHTASE (formerly INOSPHPHTASE) is a 5-element fingerprint that 
provides a signature for lithium-sensitive myo-inositol monophosphatase 
family. The fingerprint was derived from an initial alignment of 30 
sequences: the motifs were drawn from short conserved regions spanning
virtually the full alignment length, focusing on those sections that
characterise the lithium-sensitive myo-inositol monophosphatases but
distinguish them from closely related members of the inositol mono-
phosphatase superfamily. A single iteration on SPTR55_38f was required to
reach convergence, no further sequences being identified beyond the starting
set. Several partial matches were also found, all of which are family
memberst that fail to make significant matches with one or more motifs. 
Summary Information
  30 codes involving  5 elements
4 codes involving 4 elements
7 codes involving 3 elements
18 codes involving 2 elements
Composite Feature Index
53030303030
443432
370770
21141722
12345
True Positives
A5D9H1_BOVIN  A7S400_NEMVE  A9ULZ0_XENLA  IMPA1_PONPY   
IMPA2_MOUSE IMPA2_RAT MYO2_HUMAN MYOP_BOVIN
MYOP_HUMAN MYOP_MOUSE MYOP_RAT MYOP_XENLA
O77591 Q17PJ1_AEDAE Q28FW1_XENTR Q3TAU6_MOUSE
Q3TME6_MOUSE Q3U3B7_MOUSE Q3U5R8_MOUSE Q3ZLD0_OREMO
Q4R4M2_MACFA Q4S1I6_TETNG Q503S9_DANRE Q6DGB2_DANRE
Q6GM60_XENLA Q7KTW5_DROME Q7SYT9_XENLA Q924B0_MOUSE
Q9D066_MOUSE Q9VP63_DROME
True Positive Partials
Codes involving 4 elements
Q4TA02_TETNG Q5MM82_AEDAE Q7PNQ6_ANOGA Q80ZJ2_MOUSE
Codes involving 3 elements
A2XIZ6_ORYSI A9NKB3_PICSI Q018C9_OSTTA Q10HI4_ORYSJ
Q6F2U7_ORYSJ Q8LE95_ARATH Q9M8S8_ARATH
Codes involving 2 elements
A5AXB8_VITVI A7R1W5_VITVI A8QBW6_BRUMA A9NP29_PICSI
A9PIC5_POPTR A9TNR4_PHYPA MYO1_LYCES MYO3_LYCES
MYOP_MESCR Q2V3Z0_ARATH Q4QQ61_DROME Q5U788_MALDO
Q5U789_ACTDE Q84MJ7_SOLLC Q9VUW2_DROME Q9VUW3_DROME
Q9VUW4_DROME YSNM_CAEEL
Sequence Titles
A5D9H1_BOVIN Inositol(Myo)-1(Or 4)-monophosphatase 1 - Bos taurus (Bovine). 
A7S400_NEMVE Predicted protein - Nematostella vectensis (Starlet sea anemone).
A9ULZ0_XENLA Putative uncharacterized protein - Xenopus laevis (African clawed frog).
IMPA1_PONPY Inositol monophosphatase (EC 3.1.3.25) (IMPase) (IMP) (Inositol-1(or 4)-monophosphatase) (Lithium-sensitive myo-inositol monophosphatase A1) - Pongo pygmaeus (Orangutan).
IMPA2_MOUSE Inositol monophosphatase 2 (EC 3.1.3.25) (IMPase 2) (IMP 2) (Inositol- 1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2) - Mus musculus (Mouse).
IMPA2_RAT Inositol monophosphatase 2 (EC 3.1.3.25) (IMPase 2) (IMP 2) (Inositol- 1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2) - Rattus norvegicus (Rat).
MYO2_HUMAN MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE 2 (EC 3.1.3.25) (IMP 2) (INOSITOL MONOPHOSPHATASE 2) (MYO-INOSITOL MONOPHOSPHATASE A2) - HOMO SAPIENS (HUMAN).
MYOP_BOVIN MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE (EC 3.1.3.25) (IMP) (INOSITOL MONOPHOSPHATASE) (LITHIUM-SENSITIVE MYO-INOSITOL MONOPHOSPHATASE A1) - BOS TAURUS (BOVINE).
MYOP_HUMAN MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE (EC 3.1.3.25) (IMP) (INOSITOL MONOPHOSPHATASE) (LITHIUM-SENSITIVE MYO-INOSITOL MONOPHOSPHATASE A1) - HOMO SAPIENS (HUMAN).
MYOP_MOUSE MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE (EC 3.1.3.25) (IMP) (INOSITOL MONOPHOSPHATASE) (LITHIUM-SENSITIVE MYO-INOSITOL MONOPHOSPHATASE A1) - MUS MUSCULUS (MOUSE).
MYOP_RAT MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE (EC 3.1.3.25) (IMP) (INOSITOL MONOPHOSPHATASE) (LITHIUM-SENSITIVE MYO-INOSITOL MONOPHOSPHATASE A1) - RATTUS NORVEGICUS (RAT).
MYOP_XENLA MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE (EC 3.1.3.25) (IMP) (INOSITOL MONOPHOSPHATASE) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O77591 MYO-INOSITOL MONOPHOSPHATASE (EC 3.1.3.25) - SUS SCROFA (PIG).
Q17PJ1_AEDAE Myo inositol monophosphatase - Aedes aegypti (Yellowfever mosquito).
Q28FW1_XENTR Inositol(Myo)-1(Or 4)-monophosphatase 1 (Putative uncharacterized protein LOC549811) - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q3TAU6_MOUSE Activated spleen cDNA, RIKEN full-length enriched library, clone:F830001E19 product:inositol (myo)-1(or 4)-monophosphatase 2, full insert sequence - Mus musculus (Mouse).
Q3TME6_MOUSE Lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730025F01 product:inositol (myo)-1(or 4)-monophosphatase 1, full insert sequence - Mus musculus (Mouse).
Q3U3B7_MOUSE NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630109E19 product:inositol (myo)-1(or 4)- monophosphatase 2, full insert sequence - Mus musculus (Mouse).
Q3U5R8_MOUSE Bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830163F24 product:inositol (myo)-1(or 4)-monophosphatase 1, full insert sequence - Mus musculus (Mouse).
Q3ZLD0_OREMO Myo-inositol monophosphatase - Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica).
Q4R4M2_MACFA Brain cDNA, clone: QflA-11627, similar to human inositol(myo)-1(or 4)- monophosphatase 1 (IMPA1), - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Q4S1I6_TETNG Chromosome 6 SCAF14768, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q503S9_DANRE Zgc:110201 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q6DGB2_DANRE Inositol(Myo)-1(Or 4)-monophosphatase 1 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q6GM60_XENLA MGC83403 protein - Xenopus laevis (African clawed frog).
Q7KTW5_DROME CG9391-PA, isoform A (EC 3.1.3.25) (RE10407p) - Drosophila melanogaster (Fruit fly).
Q7SYT9_XENLA Impa1-prov protein - Xenopus laevis (African clawed frog).
Q924B0_MOUSE Myo-inositol monophosphatase 1 (17 days embryo heart cDNA, RIKEN full- length enriched library, clone:I920022P07 product:inositol (myo)-1(or 4)-monophosphatase 1, full insert sequence) (Adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010016C21 product:inositol (myo)-1(or 4)-monophosphatase 1, full insert sequence) (10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610002K09 product:inositol (myo)-1(or 4)- monophosphatase 1, full insert sequence) (Bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830085C21 product:inositol (myo)-1(or 4)-monophosphatase 1, full insert sequence) (Melanocyte cDNA, RIKEN full-length enriched library, clone:G270034E01 product:inositol (myo)-1(or 4)-monophosphatase 1, full insert sequence) (Blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0002C20 product:inositol (myo)-1(or 4)- monophosphatase 1, full insert sequence) (Inositol (Myo)-1(Or 4)- monophosphatase 1) (Adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630030D20 product:inositol (myo)-1(or 4)- monophosphatase 1, full insert sequence) (12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720420M18 product:inositol (myo)-1(or 4)- monophosphatase 1, full insert sequence) - Mus musculus (Mouse).
Q9D066_MOUSE 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610044K03 product:inositol (myo)-1(or 4)-monophosphatase 1, full insert sequence - Mus musculus (Mouse).
Q9VP63_DROME CG9391-PB, isoform B (EC 3.1.3.25) - Drosophila melanogaster (Fruit fly).

Q4TA02_TETNG Chromosome undetermined SCAF7478, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q5MM82_AEDAE Inositol-1 monophosphatase - Aedes aegypti (Yellowfever mosquito).
Q7PNQ6_ANOGA AGAP006570-PA - Anopheles gambiae str. PEST.
Q80ZJ2_MOUSE Impa1 protein - Mus musculus (Mouse).

A2XIZ6_ORYSI Putative uncharacterized protein - Oryza sativa subsp. indica (Rice).
A9NKB3_PICSI Putative uncharacterized protein - Picea sitchensis (Sitka spruce).
Q018C9_OSTTA Myo inositol monophosphatase isoform 2 (ISS) - Ostreococcus tauri.
Q10HI4_ORYSJ Inositol monophosphatase 3, putative, expressed - Oryza sativa subsp. japonica (Rice).
Q6F2U7_ORYSJ Putative myo-inositol monophosphatase (Putative uncharacterized protein) (Os03g0587000 protein) (Inositol monophosphatase 3, putative, expressed) - Oryza sativa subsp. japonica (Rice).
Q8LE95_ARATH Putative myo-inositol monophosphatase - Arabidopsis thaliana (Mouse-ear cress).
Q9M8S8_ARATH Putative myo-inositol monophosphatase - Arabidopsis thaliana (Mouse-ear cress).

A5AXB8_VITVI Putative uncharacterized protein - Vitis vinifera (Grape).
A7R1W5_VITVI Chromosome undetermined scaffold_383, whole genome shotgun sequence - Vitis vinifera (Grape).
A8QBW6_BRUMA Inositol-1, putative - Brugia malayi (Filarial nematode worm).
A9NP29_PICSI Putative uncharacterized protein - Picea sitchensis (Sitka spruce).
A9PIC5_POPTR Putative uncharacterized protein - Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa).
A9TNR4_PHYPA Predicted protein - Physcomitrella patens subsp. patens.
MYO1_LYCES MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE 1 (EC 3.1.3.25) (IMP 1) (INOSITOL MONOPHOSPHATASE 1) - LYCOPERSICON ESCULENTUM (TOMATO).
MYO3_LYCES MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE 3 (EC 3.1.3.25) (IMP 3) (INOSITOL MONOPHOSPHATASE 3) - LYCOPERSICON ESCULENTUM (TOMATO).
MYOP_MESCR MYO-INOSITOL-1(OR 4)-MONOPHOSPHATASE (EC 3.1.3.25) (IMP) (INOSITOL MONOPHOSPHATASE) - MESEMBRYANTHEMUM CRYSTALLINUM (COMMON ICE PLANT).
Q2V3Z0_ARATH Uncharacterized protein At3g02870.2 - Arabidopsis thaliana (Mouse-ear cress).
Q4QQ61_DROME IP09736p (IP09836p) - Drosophila melanogaster (Fruit fly).
Q5U788_MALDO L-galactose-1-phosphate phosphatase - Malus domestica (Apple) (Malus sylvestris).
Q5U789_ACTDE L-galactose-1-phosphate phosphatase - Actinidia deliciosa (Kiwi).
Q84MJ7_SOLLC Myo inositol monophosphatase isoform 1 (EC 3.1.3.25) - Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
Q9VUW2_DROME CG17029-PA (EC 3.1.3.25) - Drosophila melanogaster (Fruit fly).
Q9VUW3_DROME CG17028-PA (EC 3.1.3.25) - Drosophila melanogaster (Fruit fly).
Q9VUW4_DROME CG17027-PA (EC 3.1.3.25) (GH11740p) - Drosophila melanogaster (Fruit fly).
YSNM_CAEEL HYPOTHETICAL 37.6 KD PROTEIN F13G3.5 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.
Scan History
OWL26_0    2  100  NSINGLE    
SPTR37_9f 6 245 NSINGLE
SPTR55_38f 1 500 NSINGLE
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
AGQMVSCAVQLEKRVSSKST Q503S9_DANRE 18 18 -
AGEEVRKAGESEIKVQTKSS Q4S1I6_TETNG 19 19 -
AGAEIRKAGESEIRVMTKSS Q3ZLD0_OREMO 19 19 -
AGQIIASRNYGEKTVVEKSS Q17PJ1_AEDAE 19 19 -
AGRLIARNNEQRQDFVCKSN Q7KTW5_DROME 21 21 -
AGRLIARNNEQRQDFVCKSN Q9VP63_DROME 80 80 -
AGKMTSEAFHKDKSVLTKGC A7S400_NEMVE 24 24 -
AGSLIASRNSQRKRVVEKSS Q7PNQ6_ANOGA 19 19 -
AGEMIREALKNEMDVMIKSS MYOP_MOUSE 19 19 -
AGEMIREALKNEMDVMIKSS Q9D066_MOUSE 19 19 -
AGEMIREALKNEMDVMIKSS Q924B0_MOUSE 19 19 -
AGEMIREALKNEMDVMIKSS Q3U5R8_MOUSE 19 19 -
AGEMIREALKNEMDVMIKSS Q3TME6_MOUSE 19 19 -
AGEVVCEALKNEMNVMLKSS Q4R4M2_MACFA 19 19 -
AGEVVCEAIKNEMNVMLKSS MYOP_HUMAN 19 19 -
AGEMIREALKNKMDVMIKSS MYOP_RAT 19 19 -
AGEVVREALKNEMNIMVKSS MYOP_BOVIN 19 19 -
AGEVVREALKNETNIMVKSS A5D9H1_BOVIN 19 19 -
AGSVVCAALKEDVSVMVKSS Q7SYT9_XENLA 19 19 -
AGSVVCAALKEDVSIMVKSS Q28FW1_XENTR 19 19 -
AGEIVREALKNEMNIMIKSS O77591 19 19 -
AGSVVCAALKEDVSIMVKSS Q6GM60_XENLA 19 19 -
AGSVVCAALKEDVSIMVKTS MYOP_XENLA 20 20 -
AGQIIRKALTEEKRVSTKTS IMPA2_MOUSE 32 32 -
AGQIIRKALTEEKRVSTKTS Q3U3B7_MOUSE 32 32 -
AGQIIRKALTEEKRVSTKTS Q3TAU6_MOUSE 32 32 -
AGEIVREALQNDLKIMCKSS Q6DGB2_DANRE 19 19 -
AGQIIRKALTEEKHVSTKTS IMPA2_RAT 32 32 -
AGQIIRKALTEEKRVSTKTS MYO2_HUMAN 30 30 -
AGQVVKKALTEEKRISTKTS A9ULZ0_XENLA 51 51 -

Motif 2 width=11
Element Seqn Id St Int Rpt
GFAVNRELEFG A9ULZ0_XENLA 142 71 -
AFAVNKELEFG Q4S1I6_TETNG 112 73 -
AFAVNKELEFG Q3ZLD0_OREMO 112 73 -
ALLVNKQAEIG Q17PJ1_AEDAE 110 71 -
ALAINKEIVVG A7S400_NEMVE 115 71 -
GLKVNKVTELG Q9VP63_DROME 172 72 -
GLKVNKVTELG Q7KTW5_DROME 113 72 -
GFLVNKEMEFG MYOP_MOUSE 110 71 -
GFLVNKEMEFG Q9D066_MOUSE 110 71 -
GFLVNKEMEFG Q924B0_MOUSE 110 71 -
GFPVNKEMEFG Q3U5R8_MOUSE 110 71 -
GFLVNKEMEFG Q3TME6_MOUSE 110 71 -
GFAVNKKIEFG Q4R4M2_MACFA 110 71 -
GFAVNKKIEFG MYOP_HUMAN 110 71 -
GFVVNKEMEFG MYOP_RAT 110 71 -
GFVVNKKMEFG MYOP_BOVIN 110 71 -
GFVVNKKMEFG A5D9H1_BOVIN 110 71 -
GFAVNKQVEFG Q7SYT9_XENLA 110 71 -
GFAVNKQVEFG Q28FW1_XENTR 110 71 -
GFVVNKGMEFG O77591 110 71 -
GFAVNKQVEFG Q6GM60_XENLA 110 71 -
GFAVHKQVEFG MYOP_XENLA 113 73 -
GFAVHQELEFG IMPA2_MOUSE 123 71 -
GFAVHQELEFG Q3U3B7_MOUSE 123 71 -
GFAVHQELEFG Q3TAU6_MOUSE 123 71 -
GFAVNKTLEFG Q6DGB2_DANRE 110 71 -
GFAVHQELEFG IMPA2_RAT 123 71 -
GFAVRQELEFG MYO2_HUMAN 121 71 -
GFAVRKELEFG Q503S9_DANRE 109 71 -

Motif 3 width=19
Element Seqn Id St Int Rpt
GAFCNGQKLQVSGQKDITK Q7SYT9_XENLA 138 17 -
GAFLNGTPIRVSGETAFER Q7PNQ6_ANOGA 138 99 -
GAFRNGFPIHVSATKEISR A8QBW6_BRUMA 144 144 -
GAFKNGFPIRASKNQLLSK YSNM_CAEEL 144 144 -
GAFCNGQKLQVSQQEDITK MYOP_MOUSE 138 17 -
GAFCNGQKLQVSQQEDITK Q9D066_MOUSE 138 17 -
GAFCNGQKLQVSQQEDITK Q924B0_MOUSE 138 17 -
GAFCNGQKLQVSQQEDITK Q3U5R8_MOUSE 138 17 -
GAFCNGQKLQVSQQEDITK Q3TME6_MOUSE 138 17 -
GAFCNGQKLHVSQQEDITK Q4R4M2_MACFA 138 17 -
GAFCNGQKLQVSQQEDITK MYOP_HUMAN 138 17 -
GAFCNGQKLRVSQQEDITK MYOP_RAT 138 17 -
GAFCNGQKLQVSHQEDITK MYOP_BOVIN 138 17 -
GAFCNGQKLQVSHQEDITK A5D9H1_BOVIN 138 17 -
GAFCNGQKLQVSGQKDITK Q28FW1_XENTR 138 17 -
GAFCDGQKLQVSPQKDVTN O77591 138 17 -
GSFCNGQKLQVSGQKDITK Q6GM60_XENLA 138 17 -
GSFCNGQKLQVSGQKDITK MYOP_XENLA 141 17 -
GAFCNGQRLQVSRETDLAK IMPA2_MOUSE 151 17 -
GAFCNGQRLQVSRETDLAK Q3U3B7_MOUSE 151 17 -
GAFCNGQRLQVSRETDLAK Q3TAU6_MOUSE 151 17 -
GAFCNGQPLQVSDQKEINQ Q6DGB2_DANRE 138 17 -
GAFCNGQRLQVSRETDLAK IMPA2_RAT 151 17 -
GAFCNGQRLRVSGETDLSK MYO2_HUMAN 149 17 -
GAFCNQERLHVTQETGIRN A9ULZ0_XENLA 170 17 -
GAFCNGVRLQVSKEKDVSK Q503S9_DANRE 137 17 -
GAFCNDEPIQVSDVEEIKK Q4S1I6_TETNG 140 17 -
GAFCDNEPIAVSDVKDINR Q3ZLD0_OREMO 140 17 -
GAFMNEKAIRVSGETRLEH Q17PJ1_AEDAE 138 17 -
GAFYNGRRIHVSGQKELGK Q7KTW5_DROME 141 17 -
GAFYNGRRIHVSGQKELGK Q9VP63_DROME 200 17 -
GSYCNNKKLTVSTIKELNQ A7S400_NEMVE 143 17 -

Motif 4 width=11
Element Seqn Id St Int Rpt
TELGSNRNPEV Q7SYT9_XENLA 161 4 -
TELGSSRKPET MYOP_MOUSE 161 4 -
TELGSSRKPET Q9D066_MOUSE 161 4 -
TELGSSRKPET Q924B0_MOUSE 161 4 -
TELGSSRKPET Q3U5R8_MOUSE 161 4 -
TELGSYRKPET Q3TME6_MOUSE 161 4 -
TELGSSRTPET Q4R4M2_MACFA 161 4 -
TELGSSRTPET MYOP_HUMAN 161 4 -
TELGSSRKPET MYOP_RAT 161 4 -
TELGSSRTPET MYOP_BOVIN 161 4 -
TELGSSRTPET A5D9H1_BOVIN 161 4 -
TELGSNRNPEV Q28FW1_XENTR 161 4 -
TELGSSRTPET O77591 161 4 -
TELGSNRNPEV Q6GM60_XENLA 161 4 -
TELGSNRNPEF MYOP_XENLA 164 4 -
TEIGPKRDPDT IMPA2_MOUSE 174 4 -
TEIGPKRDPDT Q3U3B7_MOUSE 174 4 -
TEIGPKRDPDT Q3TAU6_MOUSE 174 4 -
TEFGSNRDPEN Q6DGB2_DANRE 161 4 -
TEIGPKRDPDT IMPA2_RAT 174 4 -
TEIGPKRDPAT MYO2_HUMAN 172 4 -
TEIGPKRDPAT A9ULZ0_XENLA 193 4 -
TEIGAKRDSAT Q503S9_DANRE 160 4 -
SEHGTDRRQEV Q4S1I6_TETNG 163 4 -
FEHGTDRSPEK Q3ZLD0_OREMO 163 4 -
TEFGTSRDEER Q17PJ1_AEDAE 161 4 -
SEFGTTRDEAK Q7KTW5_DROME 164 4 -
SEFGTTRDEAK Q9VP63_DROME 223 4 -
TEIGSDRSTGR A7S400_NEMVE 166 4 -
TEFGTSREEDK Q7PNQ6_ANOGA 161 4 -

Motif 5 width=23
Element Seqn Id St Int Rpt
DLMSCRVIAAGTMELAQSIAQEL A9ULZ0_XENLA 276 72 -
DLMSRRVVAAGTREIAEYVVKQL Q503S9_DANRE 243 72 -
DLMSRRMICANNKTIAERIIKEI Q4S1I6_TETNG 246 72 -
DIMSRRVLAAATPELAQEISKVL Q7KTW5_DROME 246 71 -
DIMSRRVLAAATPELAQEISKVL Q9VP63_DROME 305 71 -
DLMSRRVVACCSQEVAHAICKLI A7S400_NEMVE 251 74 -
DLMSRRIIAANSITLAKRIAKEI MYOP_MOUSE 244 72 -
DVMSRKVLCAGTAELGRDLSACL YSNM_CAEEL 254 91 -
DIMGRRVLCTSTPELARAIKSTL A8QBW6_BRUMA 254 91 -
DLMSRRVLCASTQELADKVVQTL Q7PNQ6_ANOGA 243 71 -
DLMSRRIIAANSITLAKRIAKEI Q9D066_MOUSE 244 72 -
DLMSRRIIAANSITLAKRIAKEI Q924B0_MOUSE 244 72 -
DLMSRRIIAANSITLAKRIAKEI Q3U5R8_MOUSE 244 72 -
DLMSRRIIAANSITLAKRIAKEI Q3TME6_MOUSE 244 72 -
DLMSRRVIAANNRILAERIAKEI Q4R4M2_MACFA 244 72 -
DLMSRRVIAANNRILAERIAKEI MYOP_HUMAN 244 72 -
DLMSRRVLCASSQELADKVVPLL Q17PJ1_AEDAE 243 71 -
DLMSRRIIAASNIALAERIAKEL MYOP_RAT 244 72 -
DLMSRRVIASSNKTLAERIAKEI MYOP_BOVIN 244 72 -
DLMSRRVIASSNKTLAERIAKEI A5D9H1_BOVIN 244 72 -
DLMSCRIIAASSREIAERIAKEL Q7SYT9_XENLA 244 72 -
DLMSRRMVSANNETIAKRIIKEI Q3ZLD0_OREMO 246 72 -
DLMSCRVIAASSRDIAERIAKEL Q28FW1_XENTR 244 72 -
DLMSRRVIASSNKALGERIAKEI O77591 244 72 -
DLMSCRIISASSREIAERIAKEL Q6GM60_XENLA 244 72 -
DLMSCRIISASSREIAERIAKEL MYOP_XENLA 248 73 -
DLMSCRVVAAGTREMAVLIAQAL IMPA2_MOUSE 257 72 -
DLMSCRVVAAGTREMAVLIAQAL Q3U3B7_MOUSE 257 72 -
DLMSCRVVAAGTREMAVLIAQAL Q3TAU6_MOUSE 257 72 -
DLMSRRVLAANNKTIGERIVQEV Q6DGB2_DANRE 244 72 -
DLMSCRVVAAGTREMAVLIAQAL IMPA2_RAT 257 72 -
DLMACRVVAASTREMAMLIAQAL MYO2_HUMAN 255 72 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
AGEMIREALKNEMDVMIKSS MYOP_MOUSE 19 19 -
AGEMIREALKNEMDVMIKSS Q9D066_MOUSE 19 19 -
AGEMIREALKNEMDVMIKSS Q924B0_MOUSE 19 19 -
AGEMIREALKNEMDVMIKSS Q3U5R8_MOUSE 19 19 -
AGEMIREALKNEMDVMIKSS Q3TME6_MOUSE 19 19 -
AGEVVCEALKNEMNVMLKSS Q4R4M2_MACFA 19 19 -
AGEVVCEAIKNEMNVMLKSS MYOP_HUMAN 19 19 -
AGEVVCEAIKNEMNVMLKSS IMPA1_PONPY 19 19 -
AGEMIREALKNKMDVMIKSS MYOP_RAT 19 19 -
AGEVVREALKNEMNIMVKSS MYOP_BOVIN 19 19 -
AGEVVREALKNETNIMVKSS A5D9H1_BOVIN 19 19 -
AGSVVCAALKEDVSVMVKSS Q7SYT9_XENLA 19 19 -
AGSVVCAALKEDVSIMVKSS Q28FW1_XENTR 19 19 -
AGEIVREALKNEMNIMIKSS O77591 19 19 -
AGSVVCAALKEDVSIMVKSS Q6GM60_XENLA 19 19 -
AGSVVCAALKEDVSIMVKTS MYOP_XENLA 20 20 -
AGQIIRKALTEEKRVSTKTS IMPA2_MOUSE 32 32 -
AGQIIRKALTEEKRVSTKTS Q3U3B7_MOUSE 32 32 -
AGQIIRKALTEEKRVSTKTS Q3TAU6_MOUSE 32 32 -
AGEIVREALQNDLKIMCKSS Q6DGB2_DANRE 19 19 -
AGQIIRKALTEEKHVSTKTS IMPA2_RAT 32 32 -
AGQIIRKALTEEKRVSTKTS MYO2_HUMAN 30 30 -
AGQVVKKALTEEKRISTKTS A9ULZ0_XENLA 51 51 -
AGQMVSCAVQLEKRVSSKST Q503S9_DANRE 18 18 -
AGEEVRKAGESEIKVQTKSS Q4S1I6_TETNG 19 19 -
AGAEIRKAGESEIRVMTKSS Q3ZLD0_OREMO 19 19 -
AGQIIASRNYGEKTVVEKSS Q17PJ1_AEDAE 19 19 -
AGRLIARNNEQRQDFVCKSN Q7KTW5_DROME 21 21 -
AGRLIARNNEQRQDFVCKSN Q9VP63_DROME 80 80 -
AGKMTSEAFHKDKSVLTKGC A7S400_NEMVE 24 24 -

Motif 2 width=11
Element Seqn Id St Int Rpt
GFLVNKEMEFG MYOP_MOUSE 110 71 -
GFLVNKEMEFG Q9D066_MOUSE 110 71 -
GFLVNKEMEFG Q924B0_MOUSE 110 71 -
GFPVNKEMEFG Q3U5R8_MOUSE 110 71 -
GFLVNKEMEFG Q3TME6_MOUSE 110 71 -
GFAVNKKIEFG Q4R4M2_MACFA 110 71 -
GFAVNKKIEFG MYOP_HUMAN 110 71 -
GFAVNKKIEFG IMPA1_PONPY 110 71 -
GFVVNKEMEFG MYOP_RAT 110 71 -
GFVVNKKMEFG MYOP_BOVIN 110 71 -
GFVVNKKMEFG A5D9H1_BOVIN 110 71 -
GFAVNKQVEFG Q7SYT9_XENLA 110 71 -
GFAVNKQVEFG Q28FW1_XENTR 110 71 -
GFVVNKGMEFG O77591 110 71 -
GFAVNKQVEFG Q6GM60_XENLA 110 71 -
GFAVHKQVEFG MYOP_XENLA 113 73 -
GFAVHQELEFG IMPA2_MOUSE 123 71 -
GFAVHQELEFG Q3U3B7_MOUSE 123 71 -
GFAVHQELEFG Q3TAU6_MOUSE 123 71 -
GFAVNKTLEFG Q6DGB2_DANRE 110 71 -
GFAVHQELEFG IMPA2_RAT 123 71 -
GFAVRQELEFG MYO2_HUMAN 121 71 -
GFAVNRELEFG A9ULZ0_XENLA 142 71 -
GFAVRKELEFG Q503S9_DANRE 109 71 -
AFAVNKELEFG Q4S1I6_TETNG 112 73 -
AFAVNKELEFG Q3ZLD0_OREMO 112 73 -
ALLVNKQAEIG Q17PJ1_AEDAE 110 71 -
GLKVNKVTELG Q7KTW5_DROME 113 72 -
GLKVNKVTELG Q9VP63_DROME 172 72 -
ALAINKEIVVG A7S400_NEMVE 115 71 -

Motif 3 width=19
Element Seqn Id St Int Rpt
GAFCNGQKLQVSQQEDITK MYOP_MOUSE 138 17 -
GAFCNGQKLQVSQQEDITK Q9D066_MOUSE 138 17 -
GAFCNGQKLQVSQQEDITK Q924B0_MOUSE 138 17 -
GAFCNGQKLQVSQQEDITK Q3U5R8_MOUSE 138 17 -
GAFCNGQKLQVSQQEDITK Q3TME6_MOUSE 138 17 -
GAFCNGQKLHVSQQEDITK Q4R4M2_MACFA 138 17 -
GAFCNGQKLQVSQQEDITK MYOP_HUMAN 138 17 -
GAFCNGQKLQVSQQEDITK IMPA1_PONPY 138 17 -
GAFCNGQKLRVSQQEDITK MYOP_RAT 138 17 -
GAFCNGQKLQVSHQEDITK MYOP_BOVIN 138 17 -
GAFCNGQKLQVSHQEDITK A5D9H1_BOVIN 138 17 -
GAFCNGQKLQVSGQKDITK Q7SYT9_XENLA 138 17 -
GAFCNGQKLQVSGQKDITK Q28FW1_XENTR 138 17 -
GAFCDGQKLQVSPQKDVTN O77591 138 17 -
GSFCNGQKLQVSGQKDITK Q6GM60_XENLA 138 17 -
GSFCNGQKLQVSGQKDITK MYOP_XENLA 141 17 -
GAFCNGQRLQVSRETDLAK IMPA2_MOUSE 151 17 -
GAFCNGQRLQVSRETDLAK Q3U3B7_MOUSE 151 17 -
GAFCNGQRLQVSRETDLAK Q3TAU6_MOUSE 151 17 -
GAFCNGQPLQVSDQKEINQ Q6DGB2_DANRE 138 17 -
GAFCNGQRLQVSRETDLAK IMPA2_RAT 151 17 -
GAFCNGQRLRVSGETDLSK MYO2_HUMAN 149 17 -
GAFCNQERLHVTQETGIRN A9ULZ0_XENLA 170 17 -
GAFCNGVRLQVSKEKDVSK Q503S9_DANRE 137 17 -
GAFCNDEPIQVSDVEEIKK Q4S1I6_TETNG 140 17 -
GAFCDNEPIAVSDVKDINR Q3ZLD0_OREMO 140 17 -
GAFMNEKAIRVSGETRLEH Q17PJ1_AEDAE 138 17 -
GAFYNGRRIHVSGQKELGK Q7KTW5_DROME 141 17 -
GAFYNGRRIHVSGQKELGK Q9VP63_DROME 200 17 -
GSYCNNKKLTVSTIKELNQ A7S400_NEMVE 143 17 -

Motif 4 width=11
Element Seqn Id St Int Rpt
TELGSSRKPET MYOP_MOUSE 161 4 -
TELGSSRKPET Q9D066_MOUSE 161 4 -
TELGSSRKPET Q924B0_MOUSE 161 4 -
TELGSSRKPET Q3U5R8_MOUSE 161 4 -
TELGSYRKPET Q3TME6_MOUSE 161 4 -
TELGSSRTPET Q4R4M2_MACFA 161 4 -
TELGSSRTPET MYOP_HUMAN 161 4 -
TELGSSRTPET IMPA1_PONPY 161 4 -
TELGSSRKPET MYOP_RAT 161 4 -
TELGSSRTPET MYOP_BOVIN 161 4 -
TELGSSRTPET A5D9H1_BOVIN 161 4 -
TELGSNRNPEV Q7SYT9_XENLA 161 4 -
TELGSNRNPEV Q28FW1_XENTR 161 4 -
TELGSSRTPET O77591 161 4 -
TELGSNRNPEV Q6GM60_XENLA 161 4 -
TELGSNRNPEF MYOP_XENLA 164 4 -
TEIGPKRDPDT IMPA2_MOUSE 174 4 -
TEIGPKRDPDT Q3U3B7_MOUSE 174 4 -
TEIGPKRDPDT Q3TAU6_MOUSE 174 4 -
TEFGSNRDPEN Q6DGB2_DANRE 161 4 -
TEIGPKRDPDT IMPA2_RAT 174 4 -
TEIGPKRDPAT MYO2_HUMAN 172 4 -
TEIGPKRDPAT A9ULZ0_XENLA 193 4 -
TEIGAKRDSAT Q503S9_DANRE 160 4 -
SEHGTDRRQEV Q4S1I6_TETNG 163 4 -
FEHGTDRSPEK Q3ZLD0_OREMO 163 4 -
TEFGTSRDEER Q17PJ1_AEDAE 161 4 -
SEFGTTRDEAK Q7KTW5_DROME 164 4 -
SEFGTTRDEAK Q9VP63_DROME 223 4 -
TEIGSDRSTGR A7S400_NEMVE 166 4 -

Motif 5 width=23
Element Seqn Id St Int Rpt
DLMSRRIIAANSITLAKRIAKEI MYOP_MOUSE 244 72 -
DLMSRRIIAANSITLAKRIAKEI Q9D066_MOUSE 244 72 -
DLMSRRIIAANSITLAKRIAKEI Q924B0_MOUSE 244 72 -
DLMSRRIIAANSITLAKRIAKEI Q3U5R8_MOUSE 244 72 -
DLMSRRIIAANSITLAKRIAKEI Q3TME6_MOUSE 244 72 -
DLMSRRVIAANNRILAERIAKEI Q4R4M2_MACFA 244 72 -
DLMSRRVIAANNRILAERIAKEI MYOP_HUMAN 244 72 -
DLMSRRVIAANNRILAERIAKEI IMPA1_PONPY 244 72 -
DLMSRRIIAASNIALAERIAKEL MYOP_RAT 244 72 -
DLMSRRVIASSNKTLAERIAKEI MYOP_BOVIN 244 72 -
DLMSRRVIASSNKTLAERIAKEI A5D9H1_BOVIN 244 72 -
DLMSCRIIAASSREIAERIAKEL Q7SYT9_XENLA 244 72 -
DLMSCRVIAASSRDIAERIAKEL Q28FW1_XENTR 244 72 -
DLMSRRVIASSNKALGERIAKEI O77591 244 72 -
DLMSCRIISASSREIAERIAKEL Q6GM60_XENLA 244 72 -
DLMSCRIISASSREIAERIAKEL MYOP_XENLA 248 73 -
DLMSCRVVAAGTREMAVLIAQAL IMPA2_MOUSE 257 72 -
DLMSCRVVAAGTREMAVLIAQAL Q3U3B7_MOUSE 257 72 -
DLMSCRVVAAGTREMAVLIAQAL Q3TAU6_MOUSE 257 72 -
DLMSRRVLAANNKTIGERIVQEV Q6DGB2_DANRE 244 72 -
DLMSCRVVAAGTREMAVLIAQAL IMPA2_RAT 257 72 -
DLMACRVVAASTREMAMLIAQAL MYO2_HUMAN 255 72 -
DLMSCRVIAAGTMELAQSIAQEL A9ULZ0_XENLA 276 72 -
DLMSRRVVAAGTREIAEYVVKQL Q503S9_DANRE 243 72 -
DLMSRRMICANNKTIAERIIKEI Q4S1I6_TETNG 246 72 -
DLMSRRMVSANNETIAKRIIKEI Q3ZLD0_OREMO 246 72 -
DLMSRRVLCASSQELADKVVPLL Q17PJ1_AEDAE 243 71 -
DIMSRRVLAAATPELAQEISKVL Q7KTW5_DROME 246 71 -
DIMSRRVLAAATPELAQEISKVL Q9VP63_DROME 305 71 -
DLMSRRVVACCSQEVAHAICKLI A7S400_NEMVE 251 74 -