| Literature References | 1. HYDE, G.E., CRAWFORD, N.M. AND CAMPBELL, W.H.
The sequence of squash NADH:nitrate reductase and its relationship to the
sequences of other flavoprotein oxidoreductases. A family of flavoprotein
pyridine nucleotide cytochrome reductases.
J.BIOL.CHEM. 266 23542-23547 (1991).
2. KARPLUS, P.A. AND BRUNS, C.M.
Structure-function relations for ferredoxin reductase.
J.BIOENERG.BIOMEMBR. 26 89-99 (1994).
3. CAMPBELL, W.H. AND KINGHORN, J.R.
Functional domains of assimilatory nitrate and nitrite reductases.
TRENDS BIOCHEM.SCI. 15 315-319 (1990).
4. YUBISUI, T., MIYATA, T., IWANAGA, S., TAMURA, M. AND TAKESHITA, M.
Complete amino acid sequence of NADH-cytochrome b5 reductase purified
from human erythrocytes.
J.BIOCHEM.(TOKYO) 99 407-422 (1986).
5. PORTER, T.D.
An unusual yet strongly conserved flavoprotein reductase in bacteria and
mammals.
TRENDS BIOCHEM.SCI. 16 154-158 (1991).
6. OSTROWSKI, J., BARBER, M.J., RUEGER, D.C., MILLER, B.E., SIEGEL, L.M.
AND KREDICH, N.M.
Characterization of the flavoprotein moieties of NADPH-sulphite reductase
from Salmonella typhimurium and Escherichia coli. Physicochemical and
catalytic properties, amino acid sequence deduced from DNA sequence of
cysJ, and comparison with NADPH-cytochrome P-450 reductase.
J.BIOL.CHEM. 264 15796-15808 (1989).
7. BREDT, D.S., HWANG, P.M., GLATT, C.E., LOWENSTEIN, C., REED, R.R. AND
SNYDER, S.H.
Cloned and expressed nitric oxide synthase structurally resembles
cytochrome P-450 reductase.
NATURE 351 714-718 (1991).
8. CORRELL, C.C., LUDWIG, M.L., BRUNS, C.M. AND KARPLUS, P.A.
Structural prototypes for an extended family of flavoprotein reductases:
comparison of phthalate dioxygenase reductase with ferredoxin reductase
and ferredoxin.
PROTEIN SCI. 2 2112-2133 (1993).
9. HANUKOGLU, I. AND GUTFINGER, T.
cDNA sequence of adrenodoxin reductase. Identification of NADP-binding
sites in oxidoreductases.
EUR.J.BIOCHEMISTRY 180 479-484 (1989).
10. EGGINK, G., ENGEL, H., VRIEND, G., TERPSTRA, P. AND WITHOLT, B.
Rubredoxin reductase of Pseudomonas oleovorans. Structural relationship
to other flavoprotein oxidoreductases based on one NAD and two FAD
fingerprints.
J.MOL.BIOL. 212 135-142 (1990).
11. KARPLUS, P.A., DANIELS, M.J. AND HERRIOTT, J.R.
Atomic structure for ferredoxin-NADP+ reductase: prototype for a
structurally novel flavoenzyme family.
SCIENCE 251 60-66 (1991).
12. LU, G., CAMPBELL, W.H., SCHNEIDER, G. AND LINDQVIST, Y.
Crystal structure of the FAD-containing fragment of corn nitrate reductase
at 2.5 A resolution: relationship to other flavoprotein reductases.
STRUCTURE 2 809-821 (1994).
13. NISHIDA, H., INAKA, K. AND MIKI, K.
Specific arrangement of three amino acid residues for flavin-binding barrel
structures in NADH-cytochrome b5 reductase and the other flavin-dependent
reductases.
FEBS LETT. 361 97-100 (1995).
|
| Documentation | Flavoprotein pyridine nucleotide cytochrome reductases [1] (FPNCR) catalyse
the interchange of reducing equivalents between one-electron carriers and
the two-electron-carrying nicotinamide dinucleotides. The enzymes include
ferredoxin:NADP+ reductases (FNR) [2], plant and fungal NAD(P)H:nitrate
reductases [1,3], NADH:cytochrome b5 reductases [4], NADPH:P450 reductases
[5], NADPH:sulphite reductases [6], nitric oxide synthases [7], phthalate
dioxygenase reductase [8], and various other flavoproteins.
Despite functional similarities, FPNCRs show no sequence similarity to
NADPH:adrenodoxin reductases [9], nor to bacterial ferredoxin:NAD+
reductases and their homologues [10]. To date, 3D-structures of 4 members
of the family have been solved: spinach ferredoxin:NADP+ reductase [11];
Pseudomonas cepacia phthalate dioxygenase reductase [8]; the flavoprotein
domain of corn nitrate reductase [12]; and pig NADH:cytochrome b5 reductase
[13]. In all of them, the FAD-binding domain (N-terminal) has the topology
of an anti-parallel beta-barrel, while the NAD(P)-binding domain
(C-terminal) has the topology of a classical pyridine dinucleotide-binding
fold (i.e. a central parallel beta-sheet with 2 helices on each side) [8].
In spite of such structural similarities, the level of amino acid identity
between family members is at or below the limit of significance (e.g.,
nitrate reductase is only 15% identical to FNR) [12].
FPNCR is an 8-element fingerprint that provides a signature for flavo-
protein pyridine nucleotide cytochrome reductases. The fingerprint was
derived from an initial alignment of 37 sequences: motifs 2 and 3 are
involved in binding the isoalloxazine ring and the diphosphate group of FAD
respectively; motif 4 includes residues involved in binding the diphosphate
group of the pyridine nucleotide; and motif 8 contains a conserved Cys
residue that may interacts with NAD(P)H and is necessary for efficient
electron transfer [8]. Three iterations on OWL25.1 were required to reach
convergence, at which point a true set comprising 81 sequences was
identified. Numerous partial matches were also found: the relatively poor
discrimination of this fingerprint results from the high level of sequence
divergence exhibited by members of the family.
An update on SPTR37_9f identified a true set of 87 sequences, and 90
partial matches.
|
| Sequence Titles | CPXB_BACME CYTOCHROME P450(BM-3) (P450BM-3) [INCLUDES: CYTOCHROME P450 102 (EC 1.14.14.1); NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4)] - BACILLUS MEGATERIUM.
CYSJ_ECOLI SULFITE REDUCTASE [NADPH] FLAVOPROTEIN ALPHA-COMPONENT (EC 1.8.1.2) (SIR-FP) - ESCHERICHIA COLI.
CYSJ_SALTY SULFITE REDUCTASE [NADPH] FLAVOPROTEIN ALPHA-COMPONENT (EC 1.8.1.2) (SIR-FP) - SALMONELLA TYPHIMURIUM.
FENR_ANASO FERREDOXIN--NADP REDUCTASE (EC 1.18.1.2) (FNR) - ANABAENA SP. (STRAIN PCC 7119).
FENR_ANAVA FERREDOXIN--NADP REDUCTASE (EC 1.18.1.2) (FNR) - ANABAENA VARIABILIS.
FENR_CYAPA FERREDOXIN--NADP REDUCTASE PRECURSOR (EC 1.18.1.2) (FNR) - CYANOPHORA PARADOXA.
FENR_MESCR FERREDOXIN--NADP REDUCTASE PRECURSOR (EC 1.18.1.2) (FNR) - MESEMBRYANTHEMUM CRYSTALLINUM (COMMON ICE PLANT).
FENR_ORYSA FERREDOXIN--NADP REDUCTASE, LEAF ISOZYME PRECURSOR (EC 1.18.1.2) (FNR) - ORYZA SATIVA (RICE).
FENR_PEA FERREDOXIN--NADP REDUCTASE, LEAF ISOZYME PRECURSOR (EC 1.18.1.2) (FNR) - PISUM SATIVUM (GARDEN PEA).
FENR_SPIOL FERREDOXIN--NADP REDUCTASE PRECURSOR (EC 1.18.1.2) (FNR) - SPINACIA OLERACEA (SPINACH).
FENR_SPISP FERREDOXIN--NADP REDUCTASE (EC 1.18.1.2) (FNR) - SPIRULINA SP.
FENR_SYNY3 FERREDOXIN--NADP REDUCTASE (EC 1.18.1.2) (FNR) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
FENR_TOBAC FERREDOXIN--NADP REDUCTASE, LEAF-TYPE ISOZYME PRECURSOR (EC 1.18.1.2) (FNR) - NICOTIANA TABACUM (COMMON TOBACCO).
FENR_VICFA FERREDOXIN--NADP REDUCTASE PRECURSOR (EC 1.18.1.2) (FNR) - VICIA FABA (BROAD BEAN).
FENS_ORYSA FERREDOXIN--NADP REDUCTASE, ROOT ISOZYME PRECURSOR (EC 1.18.1.2) (FNR) - ORYZA SATIVA (RICE).
FENS_PEA FERREDOXIN--NADP REDUCTASE, ROOT ISOZYME PRECURSOR (EC 1.18.1.2) (FNR) - PISUM SATIVUM (GARDEN PEA).
FENS_TOBAC FERREDOXIN--NADP REDUCTASE, ROOT-TYPE ISOZYME PRECURSOR (EC 1.18.1.2) (FNR) - NICOTIANA TABACUM (COMMON TOBACCO).
FENT_ORYSA FERREDOXIN--NADP REDUCTASE, EMBRYO ISOZYME PRECURSOR (EC 1.18.1.2) (FNR) - ORYZA SATIVA (RICE).
NCPR_CANMA NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - CANDIDA MALTOSA (YEAST).
NCPR_CANTR NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - CANDIDA TROPICALIS (YEAST).
NCPR_CATRO NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) - CATHARANTHUS ROSEUS (ROSY PERIWINKLE) (MADAGASCAR PERIWINKLE).
NCPR_CAVPO NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - CAVIA PORCELLUS (GUINEA PIG).
NCPR_HUMAN NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - HOMO SAPIENS (HUMAN).
NCPR_MOUSE NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - MUS MUSCULUS (MOUSE).
NCPR_MUSDO NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) - MUSCA DOMESTICA (HOUSE FLY).
NCPR_PHAAU NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - PHASEOLUS AUREUS (MUNG BEAN) (VIGNA RADIATA).
NCPR_PIG NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - SUS SCROFA (PIG).
NCPR_RABIT NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - ORYCTOLAGUS CUNICULUS (RABBIT).
NCPR_RAT NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - RATTUS NORVEGICUS (RAT).
NCPR_YEAST NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
NIA1_ARATH NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
NIA1_BRANA NITRATE REDUCTASE, CLONE PBNBR1405 (EC 1.6.6.1) (NR) - BRASSICA NAPUS (RAPE).
NIA1_HORVU NITRATE REDUCTASE (EC 1.6.6.1) (NR) - HORDEUM VULGARE (BARLEY).
NIA1_ORYSA NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR1) - ORYZA SATIVA (RICE).
NIA1_PHAVU NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR-1) - PHASEOLUS VULGARIS (KIDNEY BEAN) (FRENCH BEAN).
NIA1_SOYBN INDUCIBLE NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR) - GLYCINE MAX (SOYBEAN).
NIA1_TOBAC NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR1) - NICOTIANA TABACUM (COMMON TOBACCO).
NIA2_ARATH NITRATE REDUCTASE 2 (EC 1.6.6.1) (NR2) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
NIA2_BRANA NITRATE REDUCTASE, CLONE PBNBR1412 (EC 1.6.6.1) (NR) - BRASSICA NAPUS (RAPE).
NIA2_PHAVU NITRATE REDUCTASE 2 (EC 1.6.6.1) (NR-2) - PHASEOLUS VULGARIS (KIDNEY BEAN) (FRENCH BEAN).
NIA2_SOYBN INDUCIBLE NITRATE REDUCTASE 2 (EC 1.6.6.1) (NR) - GLYCINE MAX (SOYBEAN).
NIA2_TOBAC NITRATE REDUCTASE 2 (EC 1.6.6.1) (NR2) - NICOTIANA TABACUM (COMMON TOBACCO).
NIA3_MAIZE NITRATE REDUCTASE 3 (EC 1.6.6.1) (NR) - ZEA MAYS (MAIZE).
NIA7_HORVU NITRATE REDUCTASE [NAD(P)H] (EC 1.6.6.2) - HORDEUM VULGARE (BARLEY).
NIA_BETVE NITRATE REDUCTASE [NAD(P)H] (EC 1.6.6.2) (NR) - BETULA VERRUCOSA (WHITE BIRCH) (BETULA PENDULA).
NIA_CICIN NITRATE REDUCTASE (EC 1.6.6.1) (NR) - CICHORIUM INTYBUS (CHICORY).
NIA_CUCMA NITRATE REDUCTASE (EC 1.6.6.1) (NR) - CUCURBITA MAXIMA (PUMPKIN) (WINTER SQUASH).
NIA_LOTJA NITRATE REDUCTASE (EC 1.6.6.1) (NR) - LOTUS JAPONICUS.
NIA_LYCES NITRATE REDUCTASE (EC 1.6.6.1) (NR) - LYCOPERSICON ESCULENTUM (TOMATO).
NIA_PETHY NITRATE REDUCTASE (EC 1.6.6.1) (NR) - PETUNIA HYBRIDA (PETUNIA).
NIA_SPIOL NITRATE REDUCTASE (EC 1.6.6.1) (NR) - SPINACIA OLERACEA (SPINACH).
NOS1_HUMAN NITRIC-OXIDE SYNTHASE, BRAIN (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (NNOS) - HOMO SAPIENS (HUMAN).
NOS1_RAT NITRIC-OXIDE SYNTHASE, BRAIN (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (NNOS) - RATTUS NORVEGICUS (RAT).
NOS2_CHICK NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (MACROPHAGE NOS) - GALLUS GALLUS (CHICKEN).
NOS2_HUMAN NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (HEPATHOCYTE NOS) (HEP-NOS) - HOMO SAPIENS (HUMAN).
NOS2_MOUSE NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) (MACROPHAGE NOS) (MAC-NOS) - MUS MUSCULUS (MOUSE).
NOS2_RAT NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) - RATTUS NORVEGICUS (RAT).
NOS3_BOVIN NITRIC-OXIDE SYNTHASE, ENDOTHELIAL (EC 1.14.13.39) (EC-NOS) (NOS, TYPE III) (ENDOTHELIAL NOS) (ENOS) - BOS TAURUS (BOVINE).
NOS3_HUMAN NITRIC-OXIDE SYNTHASE, ENDOTHELIAL (EC 1.14.13.39) (EC-NOS) (NOS, TYPE III) (ENDOTHELIAL NOS) (ENOS) - HOMO SAPIENS (HUMAN).
O04926 NADH NITRATE REDUCTASE (EC 1.6.6.3) (NITRATE REDUCTASE (NADPH)) - SOLANUM TUBEROSUM (POTATO).
O08336 CYTOCHROME P450 102 (EC 1.14.14.1) - BACILLUS SUBTILIS.
O08394 PROBABLE CYTOCHROME P450 (YFNJ) (EC 1.14.14.1) - BACILLUS SUBTILIS.
O19132 NITRIC-OXIDE SYNTHASE, BRAIN (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (NNOS) (CONSTITUTIVE NOS) (NC-NOS) (BNOS) - ORYCTOLAGUS CUNICULUS (RABBIT).
O24390 NADH NITRATE REDUCTASE (EC 1.6.6.3) - SOLANUM TUBEROSUM (POTATO).
O24424 NADPH:FERRIHEMOPROTEIN OXIDOREDUCTASE (EC 1.6.2.4) - PAPAVER SOMNIFERUM (OPIUM POPPY).
O24425 NADPH:FERRIHEMOPROTEIN OXIDOREDUCTASE (EC 1.6.2.4) - ESCHSCHOLZIA CALIFORNICA (CALIFORNIA POPPY).
O48937 NADPH CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (NADPH--FERRIHEMOPROTEIN REDUCTASE) (NADPH--CYTOCHROME P450 REDUCTASE) (TPNH(2) CYTOCHROME C REDUCTASE) (FERRIHEMOPROTEIN P450 REDUCTASE) - PETROSELINUM CRISPUM (PARSLEY) (PETROSELINUM HORTENSE).
O48938 NADPH CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (NADPH--FERRIHEMOPROTEIN REDUCTASE) (NADPH--CYTOCHROME P450 REDUCTASE) (TPNH(2) CYTOCHROME C REDUCTASE) (FERRIHEMOPROTEIN P450 REDUCTASE) - PETROSELINUM CRISPUM (PARSLEY) (PETROSELINUM HORTENSE).
O54705 NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) - CAVIA PORCELLUS (GUINEA PIG).
O60591 NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) - HOMO SAPIENS (HUMAN).
O60604 NITRIC OXIDE SYNTHASE, INDUCIBLE (EC 1.14.13.39) (NOS, TYPE II) (INDUCIBLE NOS) (INOS) - HOMO SAPIENS (HUMAN).
O60757 INDUCIBLE NITRIC OXIDE SYNTHASE - HOMO SAPIENS (HUMAN).
O70515 NITRIC OXIDE SYNTHASE 2 - MUS MUSCULUS (MOUSE).
O70516 NITRIC OXIDE SYNTHASE 2 - MUS MUSCULUS (MOUSE).
P70313 NITRIC-OXIDE SYNTHASE, ENDOTHELIAL (EC 1.14.13.39) (EC-NOS) (NOS, TYPE III) (ENDOTHELIAL NOS) (ENOS) (CONSTITUTIVE NOS) (CNOS) - MUS MUSCULUS (MOUSE).
P70594 NEURONAL NITRIC OXIDE SYNTHASE - RATTUS NORVEGICUS (RAT).
P91655 NADPH-CYTOCHROME P450 REDUCTASE - DROSOPHILA METTLERI (FRUIT FLY).
Q00141 NADPH CYTOCHROME P450 OXIDOREDUCTASE - ASPERGILLUS NIGER.
Q00284 NITRATE REDUCTASE - ASPERGILLUS PARASITICUS.
Q09590 PROBABLE NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - CAENORHABDITIS ELEGANS.
Q27597 NADPH--FERRIHEMOPROTEIN REDUCTASE (EC 1.6.2.4) (NADPH--CYTOCHROME P450 REDUCTASE) (TPNH(2) CYTOCHROME C REDUCTASE) (FERRIHEMOPROTEIN P450 REDUCTASE) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q28969 NITRIC-OXIDE SYNTHASE, ENDOTHELIAL (EC 1.14.13.39) (EC-NOS) (NOS, TYPE III) (ENDOTHELIAL NOS) (ENOS) (CONSTITUTIVE NOS) (CNOS) - SUS SCROFA (PIG).
Q39035 NADPH-FERRIHEMOPROTEIN REDUCTASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q39036 NADPH-FERRIHEMOPROTEIN REDUCTASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q43042 NITRATE REDUCTASE APOENZYME (EC 1.6.6.1) (NITRATE REDUCTASE (NADH)) (ASSIMILATORY NITRATE REDUCTASE) - PETUNIA HYBRIDA (PETUNIA).
Q43235 NADPH-FERRIHEMOPROTEIN REDUCTASE (EC 1.6.2.4) (NADPH--FERRIHEMOPROTEIN REDUCTASE) (NADPH--CYTOCHROME P450 REDUCTASE) (TPNH(2) CYTOCHROME C REDUCTASE) (FERRIHEMOPROTEIN P450 REDUCTASE) - VICIA SATIVA (SPRING VETCH) (TARE).
Q60451 NADPH-CYTOCHROME P450 OXIDOREDUCTASE - CRICETULUS GRISEUS (CHINESE HAMSTER).
FENR_CHLRE FERREDOXIN--NADP REDUCTASE PRECURSOR (EC 1.18.1.2) (FNR) - CHLAMYDOMONAS REINHARDTII.
FENR_SYNP2 FERREDOXIN--NADP REDUCTASE (EC 1.18.1.2) (FNR) - SYNECHOCOCCUS SP. (STRAIN PCC 7002) (AGMENELLUM QUADRUPLICATUM).
NCPR_SCHPO NADPH-CYTOCHROME P450 REDUCTASE (EC 1.6.2.4) (CPR) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
NIA_ASPNG NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - ASPERGILLUS NIGER.
O61608 NITRIC-OXIDE SYNTHASE (EC 1.14.13.39) - ANOPHELES STEPHENSI (INDO-PAKISTAN MALARIA MOSQUITO).
O77104 NITRIC OXIDE SYNTHASE - MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HORNWORM).
Q12561 NITRATE REDUCTASE (EC 1.7.99.4) - ASPERGILLUS ORYZAE.
Q27571 NITRIC-OXIDE SYNTHASE (EC 1.14.13.39) (DNOS) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q41641 FERREDOXIN-NADP+ REDUCTASE - VOLVOX CARTERI.
NC5R_HUMAN NADH-CYTOCHROME B5 REDUCTASE (EC 1.6.2.2) (B5R) - HOMO SAPIENS (HUMAN).
NIA_FUSOX NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - FUSARIUM OXYSPORUM.
NIA_LEPMC NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - LEPTOSPHAERIA MACULANS (BLACKLEG FUNGUS).
O32214 YVGR PROTEIN - BACILLUS SUBTILIS.
O61309 NITRIC-OXIDE SYNTHASE (EC 1.14.13.39) (NOS, TYPE I) (NEURONAL NOS) (NNOS) - LYMNAEA STAGNALIS (GREAT POND SNAIL).
Q01696 NITRATE REDUCTASE - PENICILLIUM CHRYSOGENUM.
Q26240 NITRIC-OXIDE SYNTHASE (EC 1.14.13.39) - RHODNIUS PROLIXUS.
Q92237 NITRATE REDUCTASE - FUSARIUM MONILIFORME (GIBBERELLA FUJIKUROI).
CYSJ_THIRO SULFITE REDUCTASE [NADPH] FLAVOPROTEIN ALPHA-COMPONENT (EC 1.8.1.2) (SIR-FP) - THIOCAPSA ROSEOPERSICINA.
NC5R_BOVIN NADH-CYTOCHROME B5 REDUCTASE (EC 1.6.2.2) - BOS TAURUS (BOVINE).
NIA_BEABA NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - BEAUVERIA BASSIANA (TRITIRACHIUM SHIOTAE).
NIA_EMENI NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
NIA_NEUCR NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - NEUROSPORA CRASSA.
NIA_PICAN NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - PICHIA ANGUSTA (YEAST) (HANSENULA POLYMORPHA).
NIA_USTMA NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - USTILAGO MAYDIS (SMUT FUNGUS).
NIA_VOLCA NITRATE REDUCTASE (EC 1.6.6.1) (NR) - VOLVOX CARTERI.
O00101 NITRATE REDUCTASE (NADPH) (EC 1.6.6.3) - PHAEOSPHAERIA NODORUM (SEPTORIA NODORUM).
O13486 NITRATE REDUCTASE - METARHIZIUM ANISOPLIAE.
O84442 SULFITE REDUCTASE - CHLAMYDIA TRACHOMATIS.
MT10_YEAST SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT (EC 1.8.1.2) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
NC5R_RAT NADH-CYTOCHROME B5 REDUCTASE (EC 1.6.2.2) - RATTUS NORVEGICUS (RAT).
O16521 T05H4.5 PROTEIN - CAENORHABDITIS ELEGANS.
O16522 T05H4.4 PROTEIN - CAENORHABDITIS ELEGANS.
O60471 METHIONINE SYNTHASE REDUCTASE - HOMO SAPIENS (HUMAN).
Q00303 NITRATE REDUCTASE - BOTRYTIS CINEREA (BOTRYOTINIA FUCKELIANA).
Q12683 SULFITE REDUCTASE ALPHA SUBUNIT (EC 1.8.1.2) (SULFITE REDUCTASE (NADPH)) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q12684 ASSIMILATORY SULFITE REDUCTASE (EC 1.8.1.2) (SULFITE REDUCTASE (NADPH)) - SACCHAROMYCES PASTORIANUS (YEAST).
Q42497 NITRATE REDUCTASE - CHLORELLA VULGARIS.
BENC_ACICA BENZOATE 1,2-DIOXYGENASE ELECTRON TRANSFER COMPONENT [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE (EC 1.18.1.3)] - ACINETOBACTER CALCOACETICUS.
HMPA_VIBPA FLAVOHEMOPROTEIN (HEMOGLOBIN-LIKE PROTEIN) (FLAVOHEMOGLOBIN) - VIBRIO PARAHAEMOLYTICUS.
MCR1_YEAST NADH-CYTOCHROME B5 REDUCTASE PRECURSOR (EC 1.6.2.2) (P34/P32) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
NIA_PHYIN NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - PHYTOPHTHORA INFESTANS (POTATO LATE BLIGHT FUNGUS).
O85675 ANTHRANILATE DIOXYGENASE REDUCTASE - ACINETOBACTER SP. ADP1.
P95533 ELECTRON TRANSFER PROTEIN - PSEUDOMONAS PUTIDA.
Q12181 HYPOTHETICAL 72.3 KD PROTEIN YPR044W - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q51603 2-HALOBENZOATE 1,2-DIOXYGENASE - BURKHOLDERIA CEPACIA (PSEUDOMONAS CEPACIA).
VANB_ACICA VANILLATE O-DEMETHYLASE OXIDOREDUCTASE (EC 1.14.13.-) (VANILLATE DEGRADATION FERREDOXIN-LIKE PROTEIN) - ACINETOBACTER CALCOACETICUS.
YMM5_YEAST HYPOTHETICAL 35.3 KD PROTEIN IN HMGS-TUB3 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
ENDR_PAEPO PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN ENDR - PAENIBACILLUS POLYMYXA (BACILLUS POLYMYXA).
FENR_AZOVI FERREDOXIN--NADP REDUCTASE (EC 1.18.1.2) (FNR) (PROTEIN X) - AZOTOBACTER VINELANDII.
MEMC_METCA METHANE MONOOXYGENASE COMPONENT C (EC 1.14.13.25) (METHANE HYDROXYLASE) - METHYLOCOCCUS CAPSULATUS.
NC5R_YEAST PUTATIVE NADH-CYTOCHROME B5 REDUCTASE (EC 1.6.2.2) (P35) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
NDOR_PSEPU NAPHTHALENE 1,2-DIOXYGENASE SYSTEM FERREDOXIN--NAD(+) REDUCTASE COMPONENT (EC 1.18.1.3) - PSEUDOMONAS PUTIDA.
O05875 HYPOTHETICAL 40.8 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O05933 2-OXO-1,2-DIHYDROQUINOLINE 8-MONOOXYGENASE, REDUCTASE COMPONENT - PSEUDOMONAS PUTIDA.
O13919 HYPOTHETICAL 124.8 KD PROTEIN C23C11.15 IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O52378 FERREDOXIN REDUCTASE - PSEUDOMONAS SP.
O68591 IRON-UPTAKE FACTOR - PSEUDOMONAS AERUGINOSA.
O74557 PUTATIVE NADH-CYTOCHROME B5 REDUCTASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O84745 PHENOLHYDROLASE/NADH UBIQUINONE OXIDOREDUCTASE - CHLAMYDIA TRACHOMATIS.
O86996 HYPOTHETICAL 41.4 KD PROTEIN - ACINETOBACTER LWOFFII K24.
P74344 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P92949 FRO2 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P94680 TOLUENESULFONATE METHYL-MONOOXYGENASE REDUCTASE COMPONENT - COMAMONAS TESTOSTERONI (PSEUDOMONAS TESTOSTERONI).
P95277 HYPOTHETICAL 93.4 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
P95561 REDUCTASE 2NT - PSEUDOMONAS SP.
POBB_PSEPS PHENOXYBENZOATE DIOXYGENASE BETA SUBUNIT (EC 1.-.-.-) (4-CARBOXYDIPHENYL ETHER;PHENOXYBENZOATE DIOXYGENASE BETA SUBUNIT) - PSEUDOMONAS PSEUDOALCALIGENES.
Q17574 C01G6.6 PROTEIN - CAENORHABDITIS ELEGANS.
Q44253 ANILINE DIOXYGENASE REDUCTASE COMPONENT - ACINETOBACTER SP.
Q51492 REDUCTASE - PSEUDOMONAS AERUGINOSA.
Q52140 FERREDOXIN REDUCTASE (EC 1.-.-.-) - PSEUDOMONAS PUTIDA.
Q53028 REDUCTASE - NOCARDIA CORALLINA.
RFBI_SALTY RFBI PROTEIN - SALMONELLA TYPHIMURIUM.
VANB_PSEPU VANILLATE O-DEMETHYLASE OXIDOREDUCTASE (EC 1.14.13.-) (VANILLATE DEGRADATION FERREDOXIN-LIKE PROTEIN) - PSEUDOMONAS PUTIDA.
VANB_PSES9 VANILLATE O-DEMETHYLASE OXIDOREDUCTASE (EC 1.14.13.-) (VANILLATE DEGRADATION FERREDOXIN-LIKE PROTEIN) - PSEUDOMONAS SP. (STRAIN ATCC 19151).
VANB_PSESP VANILLATE O-DEMETHYLASE OXIDOREDUCTASE (EC 1.14.13.-) (VANILLATE DEGRADATION FERREDOXIN-LIKE PROTEIN) - PSEUDOMONAS SP. (STRAIN HR199 / DSM 7063).
XYLZ_PSEPU TOLUATE 1,2-DIOXYGENASE ELECTRON TRANSFER COMPONENT [INCLUDES: FERREDOXIN; FERREDOXIN--NAD(+) REDUCTASE (EC 1.18.1.3)] - PSEUDOMONAS PUTIDA.
YEAX_ECOLI PUTATIVE DIOXYGENASE BETA SUBUNIT YEAX (EC 1.-.-.-) - ESCHERICHIA COLI.
YMI7_YEAST HYPOTHETICAL 35.8 KD PROTEIN IN RPM2-TUB1 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
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