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PR00363

Identifier
CYTOCHROMEB5  [View Relations]  [View Alignment]  
Accession
PR00363
No. of Motifs
4
Creation Date
22-FEB-1995  (UPDATE 14-JUN-1999)
Title
Cytochrome B5 signature
Database References

PROSITE; PS00191 CYTOCHROME_B5
BLOCKS; BL00191
PFAM; PF00173 heme_1
INTERPRO; IPR001199
PDB; 3B5C; 1FCB
SCOP; 3B5C; 1FCB
CATH; 3B5C; 1FCB
Literature References
1. OZOLS, J.
Structure of cytochrome b5 and its topology in the microsomal membrane.
BIOCHIM.BIOPHYS.ACTA 997 121-130 (1989).
 
2. LEDERER, F. 
The cytochrome b5-fold: an adaptable module.
BIOCHIMIE 76 674-692 (1994).
 
3. ABE, K., KIMURA, S., KIZAWA, R., ANAN, F.K. AND SUGITA, Y.  
Amino acid sequences of cytochrome b5 from human, porcine, and bovine
erythrocytes and comparison with liver microsomal cytochrome b5.
J.BIOCHEM.(TOKYO) 97 1659-1668 (1985).
 
4. GIORDANO, S.J. AND STEGGLES, A.W.
Differential expression of the mRNAs for the soluble and membrane-bound 
forms of rabbit cytochrome b5.
BIOCHIM.BIOPHYS.ACTA 1172 95-100 (1993).
 
5. ARGOS, P. AND MATHEWS, F.S.
The structure of ferrocytochrome b5 at 2.8 A resolution. 
J.BIOL.CHEM. 250 747-751 (1975). 
 
6. CAMPBELL, W.H. AND KINGHORN, J.R.
Functional domains of assimilatory nitrate and nitrite reductases.
TRENDS BIOCHEM.SCI. 15 315-319 (1990).
 
7. GUIARD, B. AND LEDERER, F. 
The "b5-like" domain from chicken-liver sulfite oxidase: a new case of 
common ancestral origin with liver cytochrome b5 and bakers' yeast 
cytochrome b2 core.  
EUR.J.BIOCHEMISTRY 74 181-190 (1977).
 
8. XIA, Z.X. AND MATHEWS, F.S.
Molecular structure of flavocytochrome b2 at 2.4 A resolution.
J.MOL.BIOL. 212 837-863 (1990).
 
9. SPERLING, P., SCHMIDT, H. AND HEINZ, E. 
A cytochrome-b5-containing fusion protein similar to plant acyl lipid 
desaturases.
EUR.J.BIOCHEMISTRY 232 798-805 (1995).

Documentation
Cytochromes b5 (cyt b5) are ubiquitous electron transport proteins found in
animals, plants and yeasts [1,2]. The microsomal and mitochondrial variants
are membrane-bound, while those from erythrocytes and other animal tissues
are water-soluble [3,4]. The 3D structure of bovine cyt b5 is known, the 
fold belonging to the alpha+beta class, with 5 strands and 5 short helices
forming a framework for supporting a central haem group [5]. The haem
domain is similar to that of a number of oxidoreductases, such as plant
and fungal nitrate reductases [6], sulphite oxidase [7], yeast 
flavocytochrome b2 (L-lactate dehydrogenase) [8] and plant cyt b5/acyl 
lipid desaturase fusion protein [9]. Within this domain, 2 conserved His 
residues serve as axial ligands for the haem [5,8]. 
 
CYTOCHROMEB5 is a 4-element fingerprint that provides a signature for 
cyt b5 and cyt b5-like domains. The fingerprint was derived from an initial
alignment of 24 sequences: motifs 1 and 2 are adjacent, spanning the first
invariant His, which provides one of the haem ligands - within the 
structure, they correspond to beta-strand 4 (32-35) and helix 2 (48-51) of 
bovine cyt b5 [5]; motif 3 spans helix 3 (59-64); and motif 4 spans the
greater part of helix 4 (69-75) and beta-strand 6 (79-83). The second
His residue, which serves as an axial haem ligand, is situated in the
loop of variable length between helices 3 and 4. Two iterations on OWL28.1
were required to reach convergence, at which point a true set comprising 79
sequences was identified. Five partial matches were also found, all of 
which fail to make significant matches with motifs 3 or 4: they include 
sunflower cyt b5/acyl lipid desaturase fusion protein (HACYTB5RN) [9], 
rape expressed sequence tag (PQ0816), and 3 yeast hypothetical proteins 
(S54484, SPAC1F129, S52833).
 
An update on SPTR37_9f identified a true set of 66 sequences, and 24
partial matches.
Summary Information
  66 codes involving  4 elements
7 codes involving 3 elements
16 codes involving 2 elements
Composite Feature Index
466666666
37716
2161600
1234
True Positives
CYB5_BOVIN    CYB5_BRAOL    CYB5_CHICK    CYB5_CUSRE    
CYB5_HORSE CYB5_HUMAN CYB5_MOUSE CYB5_MUSDO
CYB5_ORYSA CYB5_PIG CYB5_RABIT CYB5_RAT
CYB5_TOBAC CYB5_YEAST CYS5_TOBAC NIA1_ARATH
NIA1_BRANA NIA1_HORVU NIA1_ORYSA NIA1_PHAVU
NIA1_SOYBN NIA1_TOBAC NIA2_ARATH NIA2_BRANA
NIA2_PHAVU NIA2_SOYBN NIA2_TOBAC NIA3_MAIZE
NIA7_HORVU NIA_ASPNG NIA_BEABA NIA_BETVE
NIA_CICIN NIA_CUCMA NIA_EMENI NIA_FUSOX
NIA_LEPMC NIA_LOTJA NIA_LYCES NIA_NEUCR
NIA_PETHY NIA_PHYIN NIA_PICAN NIA_SPIOL
NIA_USTMA NIA_VOLCA O00101 O04354
O04926 O13486 O17733 O24390
O35768 O48845 O60427 O76336
P70116 Q00284 Q00303 Q01696
Q12561 Q28726 Q42497 Q43042
Q92237 Q93315
True Positive Partials
Codes involving 3 elements
O01816 O13510 O22704 O74212
SUOX_CHICK SUOX_HUMAN SUOX_RAT
Codes involving 2 elements
CYB2_HANAN CYB2_YEAST CYBR_DROME CYBR_DROVI
O13378 O74875 O82348 P79049
P79077 P79078 Q12618 Q12619
Q43469 YDAA_SCHPO YM8I_YEAST YMW3_YEAST
Sequence Titles
CYB5_BOVIN  CYTOCHROME B5 - BOS TAURUS (BOVINE).          
CYB5_BRAOL CYTOCHROME B5 - BRASSICA OLERACEA (CAULIFLOWER).
CYB5_CHICK CYTOCHROME B5 - GALLUS GALLUS (CHICKEN).
CYB5_CUSRE CYTOCHROME B5 - CUSCUTA REFLEXA (SOUTHERN ASIAN DODDER).
CYB5_HORSE CYTOCHROME B5 - EQUUS CABALLUS (HORSE).
CYB5_HUMAN CYTOCHROME B5 - HOMO SAPIENS (HUMAN).
CYB5_MOUSE CYTOCHROME B5 - MUS MUSCULUS (MOUSE).
CYB5_MUSDO CYTOCHROME B5 (CYTB5) - MUSCA DOMESTICA (HOUSE FLY).
CYB5_ORYSA CYTOCHROME B5 - ORYZA SATIVA (RICE).
CYB5_PIG CYTOCHROME B5 - SUS SCROFA (PIG).
CYB5_RABIT CYTOCHROME B5 - ORYCTOLAGUS CUNICULUS (RABBIT).
CYB5_RAT CYTOCHROME B5 - RATTUS NORVEGICUS (RAT).
CYB5_TOBAC CYTOCHROME B5 - NICOTIANA TABACUM (COMMON TOBACCO).
CYB5_YEAST CYTOCHROME B5 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
CYS5_TOBAC CYTOCHROME B5, SEED ISOFORM - NICOTIANA TABACUM (COMMON TOBACCO).
NIA1_ARATH NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
NIA1_BRANA NITRATE REDUCTASE, CLONE PBNBR1405 (EC 1.6.6.1) (NR) - BRASSICA NAPUS (RAPE).
NIA1_HORVU NITRATE REDUCTASE (EC 1.6.6.1) (NR) - HORDEUM VULGARE (BARLEY).
NIA1_ORYSA NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR1) - ORYZA SATIVA (RICE).
NIA1_PHAVU NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR-1) - PHASEOLUS VULGARIS (KIDNEY BEAN) (FRENCH BEAN).
NIA1_SOYBN INDUCIBLE NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR) - GLYCINE MAX (SOYBEAN).
NIA1_TOBAC NITRATE REDUCTASE 1 (EC 1.6.6.1) (NR1) - NICOTIANA TABACUM (COMMON TOBACCO).
NIA2_ARATH NITRATE REDUCTASE 2 (EC 1.6.6.1) (NR2) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
NIA2_BRANA NITRATE REDUCTASE, CLONE PBNBR1412 (EC 1.6.6.1) (NR) - BRASSICA NAPUS (RAPE).
NIA2_PHAVU NITRATE REDUCTASE 2 (EC 1.6.6.1) (NR-2) - PHASEOLUS VULGARIS (KIDNEY BEAN) (FRENCH BEAN).
NIA2_SOYBN INDUCIBLE NITRATE REDUCTASE 2 (EC 1.6.6.1) (NR) - GLYCINE MAX (SOYBEAN).
NIA2_TOBAC NITRATE REDUCTASE 2 (EC 1.6.6.1) (NR2) - NICOTIANA TABACUM (COMMON TOBACCO).
NIA3_MAIZE NITRATE REDUCTASE 3 (EC 1.6.6.1) (NR) - ZEA MAYS (MAIZE).
NIA7_HORVU NITRATE REDUCTASE [NAD(P)H] (EC 1.6.6.2) - HORDEUM VULGARE (BARLEY).
NIA_ASPNG NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - ASPERGILLUS NIGER.
NIA_BEABA NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - BEAUVERIA BASSIANA (TRITIRACHIUM SHIOTAE).
NIA_BETVE NITRATE REDUCTASE [NAD(P)H] (EC 1.6.6.2) (NR) - BETULA VERRUCOSA (WHITE BIRCH) (BETULA PENDULA).
NIA_CICIN NITRATE REDUCTASE (EC 1.6.6.1) (NR) - CICHORIUM INTYBUS (CHICORY).
NIA_CUCMA NITRATE REDUCTASE (EC 1.6.6.1) (NR) - CUCURBITA MAXIMA (PUMPKIN) (WINTER SQUASH).
NIA_EMENI NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
NIA_FUSOX NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - FUSARIUM OXYSPORUM.
NIA_LEPMC NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - LEPTOSPHAERIA MACULANS (BLACKLEG FUNGUS).
NIA_LOTJA NITRATE REDUCTASE (EC 1.6.6.1) (NR) - LOTUS JAPONICUS.
NIA_LYCES NITRATE REDUCTASE (EC 1.6.6.1) (NR) - LYCOPERSICON ESCULENTUM (TOMATO).
NIA_NEUCR NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - NEUROSPORA CRASSA.
NIA_PETHY NITRATE REDUCTASE (EC 1.6.6.1) (NR) - PETUNIA HYBRIDA (PETUNIA).
NIA_PHYIN NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - PHYTOPHTHORA INFESTANS (POTATO LATE BLIGHT FUNGUS).
NIA_PICAN NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - PICHIA ANGUSTA (YEAST) (HANSENULA POLYMORPHA).
NIA_SPIOL NITRATE REDUCTASE (EC 1.6.6.1) (NR) - SPINACIA OLERACEA (SPINACH).
NIA_USTMA NITRATE REDUCTASE [NADPH] (EC 1.6.6.3) (NR) - USTILAGO MAYDIS (SMUT FUNGUS).
NIA_VOLCA NITRATE REDUCTASE (EC 1.6.6.1) (NR) - VOLVOX CARTERI.
O00101 NITRATE REDUCTASE (NADPH) (EC 1.6.6.3) - PHAEOSPHAERIA NODORUM (SEPTORIA NODORUM).
O04354 CYTOCHROME B5 - BORAGO OFFICINALIS (BOURRACHE).
O04926 NADH NITRATE REDUCTASE (EC 1.6.6.3) (NITRATE REDUCTASE (NADPH)) - SOLANUM TUBEROSUM (POTATO).
O13486 NITRATE REDUCTASE - METARHIZIUM ANISOPLIAE.
O17733 D2023.1 PROTEIN - CAENORHABDITIS ELEGANS.
O24390 NADH NITRATE REDUCTASE (EC 1.6.6.3) - SOLANUM TUBEROSUM (POTATO).
O35768 CYTOCHROME B5 - RATTUS NORVEGICUS (RAT).
O48845 PUTATIVE CYTOCHROME B5 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O60427 BC269730_2 - HOMO SAPIENS (HUMAN).
O76336 CYTOCHROME B5 - HELICOVERPA ARMIGERA (COTTON BOLLWORM).
P70116 CYTOCHROME B5 - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
Q00284 NITRATE REDUCTASE - ASPERGILLUS PARASITICUS.
Q00303 NITRATE REDUCTASE - BOTRYTIS CINEREA (BOTRYOTINIA FUCKELIANA).
Q01696 NITRATE REDUCTASE - PENICILLIUM CHRYSOGENUM.
Q12561 NITRATE REDUCTASE (EC 1.7.99.4) - ASPERGILLUS ORYZAE.
Q28726 SOLUBLE CYTOCHROME B5 - ORYCTOLAGUS CUNICULUS (RABBIT).
Q42497 NITRATE REDUCTASE - CHLORELLA VULGARIS.
Q43042 NITRATE REDUCTASE APOENZYME (EC 1.6.6.1) (NITRATE REDUCTASE (NADH)) (ASSIMILATORY NITRATE REDUCTASE) - PETUNIA HYBRIDA (PETUNIA).
Q92237 NITRATE REDUCTASE - FUSARIUM MONILIFORME (GIBBERELLA FUJIKUROI).
Q93315 C31E10.7 PROTEIN - CAENORHABDITIS ELEGANS.

O01816 SIMILAR TO CYTOCHROME B5 - CAENORHABDITIS ELEGANS.
O13510 L-MANDELATE DEHYDROGENASE PRECURSOR (EC 1.1.2.3) - RHODOTORULA GRAMINIS.
O22704 PUTATIVE CYTOCHROME B5 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O74212 DELTA(5)-DESATURASE (EC 1.14.99.-) - MORTIERELLA ALPINA.
SUOX_CHICK SULFITE OXIDASE (EC 1.8.3.1) - GALLUS GALLUS (CHICKEN).
SUOX_HUMAN SULFITE OXIDASE PRECURSOR (EC 1.8.3.1) - HOMO SAPIENS (HUMAN).
SUOX_RAT SULFITE OXIDASE PRECURSOR (EC 1.8.3.1) - RATTUS NORVEGICUS (RAT).

CYB2_HANAN CYTOCHROME B2 PRECURSOR (EC 1.1.2.3) (L-LACTATE DEHYDROGENASE (CYTOCHROME)) (L-LACTATE FERRICYTOCHROME C OXIDOREDUCTASE) (L-LCR) - HANSENULA ANOMALA (YEAST) (CANDIDA PELLICULOSA).
CYB2_YEAST CYTOCHROME B2 PRECURSOR (EC 1.1.2.3) (L-LACTATE DEHYDROGENASE (CYTOCHROME)) (L-LACTATE FERRICYTOCHROME C OXIDOREDUCTASE) (L-LCR) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
CYBR_DROME PROTEIN TU-36B (CYTOCHROME B5-RELATED PROTEIN) - DROSOPHILA MELANOGASTER (FRUIT FLY).
CYBR_DROVI CYTOCHROME B5 RELATED PROTEIN - DROSOPHILA VIRILIS (FRUIT FLY).
O13378 ACYL-COA DESATURASE 1 (EC 1.14.99.5) (STEAROYL-COA DESATURASE 1) (FATTY ACID DESATURASE 1) - MUCOR ROUXII.
O74875 PUTATIVE CYTOCHROME B5 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O82348 PUTATIVE CYTOCHROME B5 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P79049 ACYL-COA DESATURASE 1 (EC 1.14.99.5) (STEAROYL-COA DESATURASE 1) (DELTA 9-FATTY ACID DESATURASE) - PICHIA ANGUSTA (YEAST) (HANSENULA POLYMORPHA).
P79077 DELTA-9 FATTY ACID DESATURASE (EC 1.14.99.5) (STEAROYL-COA DESATURASE) (ACYL-COA DESATURASE) (DELTA(9)-DESATURASE) - CRYPTOCOCCUS CURVATUS.
P79078 DELTA-9 FATTY ACID DESATURASE (EC 1.14.99.5) (STEAROYL-COA DESATURASE) (ACYL-COA DESATURASE) (DELTA(9)-DESATURASE) - CRYPTOCOCCUS CURVATUS.
Q12618 ACYL-COA DESATURASE 1 (EC 1.14.99.5) (STEAROYL-COA DESATURASE 1) (FATTY ACID DESATURASE 1) - AJELLOMYCES CAPSULATA (HISTOPLASMA CAPSULATUM).
Q12619 ACYL-COA DESATURASE 1 (EC 1.14.99.5) (STEAROYL-COA DESATURASE 1) (FATTY ACID DESATURASE 1) - AJELLOMYCES CAPSULATA (HISTOPLASMA CAPSULATUM).
Q43469 CYTOCHROME B5 CONTAINING FUSION PROTEIN - HELIANTHUS ANNUUS (COMMON SUNFLOWER).
YDAA_SCHPO HYPOTHETICAL 16.7 KD PROTEIN C1F12.10C IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
YM8I_YEAST HYPOTHETICAL 44.9 KD PROTEIN IN URA10-NRC1 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YMW3_YEAST HYPOTHETICAL 23.2 KD PROTEIN IN ABF2-CHL12 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Scan History
OWL28_0    2  1000 NSINGLE    
SPTR37_9f 2 300 NSINGLE
Initial Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
LYDGTGFLKDH NIA_USTMA 541 541 -
VYDLTKFLEEH CYB5_BOVIN 33 33 -
VYDLTKFLEEH CYB5_HUMAN 33 33 -
VYDGTAFLEGH NIA_EMENI 537 537 -
VYDGTPYLSGH NIA_FUSOX 571 571 -
VYDCTAFLKDH NIA7_HORVU 540 540 -
IYDATRFLKDH NIA2_TOBAC 556 556 -
IYDCTRFLMDH NIA2_ARATH 567 567 -
IYDCTRFLKDH NIA1_ARATH 570 570 -
VYDCTRFLKDH NIA_CUCMA 568 568 -
VYDITRFLSEH CYM5_RAT 34 34 -
VYDLTKFLEEH JN0316 34 34 -
IYDFTSFIDKH CYBR_DROME 49 49 -
VYDLTKFLEEH CBHU5E 34 34 -
VYDLTRFLPNH CYB2_YEAST 113 113 -
VYDLTDFLPNH CYB2_HANAN 105 105 -
VYDCTAFLKDH NIA2_HORVU 560 560 -
VFDVTKFVDLH SUOX_RAT 51 51 -
VFDVTDFVELH SUOX_CHICK 30 30 -
VFDVTEFVDLH S55874 51 51 -
VYDVSQFKDEH CYB5_YEAST 27 27 -
VYNVSKFLEDH CYB5_ORYSA 31 31 -
VYDVTKFLDDH CYB5_CUSRE 29 29 -
VYDVTKFLDDH CYB5_TOBAC 30 30 -

Motif 2 width=15
Element Seqn Id St Int Rpt
HPGGEEVLREQAGGD JN0316 44 -1 -
HPGGPFWIRETKGTD CYBR_DROME 59 -1 -
HPGGEEVLLEQAGAD CYM5_RAT 44 -1 -
HPGGEEVLREQAGGD CBHU5E 44 -1 -
HPGGQDVIKFNAGKD CYB2_YEAST 123 -1 -
HPGGQKIIIRYAGKD CYB2_HANAN 115 -1 -
HPGGADSILINAGSD NIA2_HORVU 570 -1 -
HPGGQSKLMLAAGGP SUOX_RAT 61 -1 -
HPGGPDKILLAAGGA SUOX_CHICK 40 -1 -
HPGGPSKLMLAAGGP S55874 61 -1 -
HPGGSDSILINAGTD NIA_CUCMA 578 -1 -
HPGGTDSILINAGTD NIA1_ARATH 580 -1 -
HPGGSDSILINAGTD NIA2_ARATH 577 -1 -
HPGGTDSILINAGTD NIA2_TOBAC 566 -1 -
HPGGADSILINAGSD NIA7_HORVU 550 -1 -
HPGGAASIFGAAGQD NIA_FUSOX 581 -1 -
HPGGAQSIISAAGTD NIA_EMENI 547 -1 -
HPGGEEVLREQAGGD CYB5_HUMAN 43 -1 -
HPGGEEVLREQAGGD CYB5_BOVIN 43 -1 -
HPGGDQSIVLSPGED NIA_USTMA 551 -1 -
HPGGDEVLLSATGKD CYB5_TOBAC 40 -1 -
HPGGADVLLSSTAKD CYB5_CUSRE 39 -1 -
HPGGDDVLLSSTGKD CYB5_ORYSA 41 -1 -
HPGGDEIIMDLGGQD CYB5_YEAST 37 -1 -

Motif 3 width=8
Element Seqn Id St Int Rpt
CTEEFDAI NIA7_HORVU 565 0 -
ATEEFMAI NIA_FUSOX 596 0 -
ASEEFLEI NIA_EMENI 562 0 -
ATENFEDV CYB5_HUMAN 58 0 -
ATENFEDV CYB5_BOVIN 58 0 -
ATEDFMAI NIA_USTMA 567 1 -
ATDDFEDV CYB5_TOBAC 55 0 -
ATDDFEDI CYB5_CUSRE 54 0 -
ATDDFEDV CYB5_ORYSA 56 0 -
ATESFVDI CYB5_YEAST 52 0 -
ITEAFEAH CYBR_DROME 74 0 -
VTAIFEPL CYB2_YEAST 138 0 -
ATENFEDV CBHU5E 59 0 -
ATENFEDV JN0316 59 0 -
ATESFEDV CYM5_RAT 59 0 -
CTEEFDAI NIA_CUCMA 593 0 -
CTEEFEAI NIA1_ARATH 595 0 -
ATKIFVPI CYB2_HANAN 130 0 -
CTEEFEAI NIA2_ARATH 592 0 -
CTEEFDAI NIA2_TOBAC 581 0 -
PLEPFWAL S55874 75 -1 -
ALEPFWAL SUOX_CHICK 54 -1 -
PLEPFWAL SUOX_RAT 75 -1 -
CTEEFDAI NIA2_HORVU 585 0 -

Motif 4 width=13
Element Seqn Id St Int Rpt
ARELSKTFIIGEL JN0316 72 5 -
AKKMLEDYRIGEL NIA_CUCMA 605 4 -
AKKLLEDYRIGEL NIA1_ARATH 607 4 -
AKKMLEDYRIGEL NIA2_ARATH 604 4 -
AKKLLEDFRIGEL NIA2_TOBAC 593 4 -
ARGLLEMYRVGEL NIA7_HORVU 577 4 -
AKAMLPTYHIGTL NIA_FUSOX 608 4 -
AKKMMPDYHIGTL NIA_EMENI 574 4 -
AREMSKTFIIGEL CYB5_HUMAN 71 5 -
ARELSKTFIIGEL CYB5_BOVIN 71 5 -
AKKMLRDFHLGRL NIA_USTMA 579 4 -
ARAMLDEYYVGDI CYB5_TOBAC 68 5 -
ARAMMDEMCVGDI CYB5_CUSRE 67 5 -
ARAMMDEYYVGDI CYB5_ORYSA 69 5 -
ALRLLKGLYIGDV CYB5_YEAST 65 5 -
DKYIAPEKKLGPL CYB2_YEAST 152 6 -
EKFIPPEKHLGPL CYB2_HANAN 144 6 -
AKALLDTYRIGEL NIA2_HORVU 597 4 -
VRELLAEYKIGEL SUOX_RAT 91 8 -
VLELLQQYKVGEL SUOX_CHICK 70 8 -
VRELLAQYKIGEL S55874 91 8 -
AREMSKTFIIGEL CBHU5E 72 5 -
AREMLKQYYIGDV CYM5_RAT 72 5 -
PEKMIAKYKVRDA CYBR_DROME 87 5 -
Final Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
VYDCTRFLKDH NIA1_PHAVU 540 540 -
VYDCTRFLKDH NIA_CUCMA 568 568 -
VYDCTRFLKDH NIA2_SOYBN 542 542 -
VYDCTRFLKDH NIA2_PHAVU 538 538 -
VYDCTRFLKDH NIA_LOTJA 546 546 -
VYDCTAFLKDH NIA1_ORYSA 566 566 -
IYDCTRFLKDH NIA1_BRANA 564 564 -
IYDCTRFLKDH NIA2_BRANA 564 564 -
IYDCTRFLKDH NIA1_ARATH 570 570 -
VYDCTAFLKDH NIA1_HORVU 563 563 -
VYDATRFLKDH Q43042 566 566 -
VYDATRFLKDH NIA_PETHY 560 560 -
VYDWTRFLKDH NIA1_SOYBN 538 538 -
IYDCTRFLMDH NIA2_ARATH 567 567 -
IYDCTHFLKDH NIA_BETVE 553 553 -
VYDCTAFLKDH NIA3_MAIZE 545 545 -
IYDATRFLKDH NIA2_TOBAC 556 556 -
IYDATRFLKDH NIA1_TOBAC 556 556 -
VYNATRFLKDH NIA_SPIOL 576 576 -
VYDCTAFLKDH NIA7_HORVU 540 540 -
IYDCTSFLKDH NIA_CICIN 559 559 -
IYDASRFLKDH NIA_LYCES 561 561 -
IYDASRFLKDH O24390 561 561 -
IYDASRFLKDH O04926 561 561 -
VYDATPFLKDH Q42497 527 527 -
VYDLTKFLEDH CYB5_HORSE 33 33 -
VYDGTPYLSGH NIA_FUSOX 571 571 -
VYDGTPYLSGH Q92237 573 573 -
VYDLTKFLEEH CYB5_MOUSE 33 33 -
VYDLTKFLEEH CYB5_RAT 33 33 -
VYDLTKFLEEH O35768 34 34 -
VYDGTAFLEGH NIA_EMENI 537 537 -
VYDLTKFLEEH CYB5_HUMAN 33 33 -
VYDLTKFLEEH CYB5_BOVIN 33 33 -
VYDLTKFLEEH CYB5_PIG 33 33 -
VYDLTKFLEEH CYB5_RABIT 33 33 -
VYDLTKFLEEH P70116 34 34 -
VYDLTKFLEEH Q28726 34 34 -
VYDGTAFLEGH O00101 560 560 -
VYDGTSFLEGH NIA_LEPMC 561 561 -
VYDGTPFLEGH O13486 562 562 -
VYNGTPFLEGH NIA_NEUCR 642 642 -
VYDGTAFLEGH NIA_ASPNG 539 539 -
VYDATPYLDEH NIA_VOLCA 522 522 -
VYDVTKFLEDH O04354 27 27 -
IYDITKFLDEH CYB5_CHICK 39 39 -
VYDGTAFLEGH Q01696 536 536 -
VYDVTAFLNEH CYB5_MUSDO 31 31 -
LYDGTGFLKDH NIA_USTMA 541 541 -
VYDGQAFLEGH Q12561 539 539 -
VYDGQAFLEGH Q00284 539 539 -
VYDATPFLDEH NIA_PHYIN 562 562 -
VYNGTPYLDNH NIA_BEABA 560 560 -
VYNVTKFLEDH CYS5_TOBAC 30 30 -
VYDVTKFLDDH CYB5_TOBAC 30 30 -
VYNVTKFLEDH O48845 30 30 -
VYDGAPFLEGH Q00303 563 563 -
VYDVTPFMDDH CYB5_BRAOL 30 30 -
VFDVTKFLDEH Q93315 33 33 -
VYDVTKFLDDH CYB5_CUSRE 29 29 -
VYNVSKFLEDH CYB5_ORYSA 31 31 -
VYDVTKFVDLH O17733 28 28 -
VYNVTKFLDEH O76336 28 28 -
VFDGSSYLEDH NIA_PICAN 528 528 -
VYDVSQFKDEH CYB5_YEAST 27 27 -
VYNISEFTRRH O60427 42 42 -

Motif 2 width=15
Element Seqn Id St Int Rpt
HPGGEDSILLNAGTD NIA1_PHAVU 550 -1 -
HPGGSDSILINAGTD NIA_CUCMA 578 -1 -
HPGGTDSILINAGTD NIA2_SOYBN 552 -1 -
HPGGTDSILINAGTD NIA2_PHAVU 548 -1 -
HPGGADSILINAGTD NIA_LOTJA 556 -1 -
HPGGADSILINAGTD NIA1_ORYSA 576 -1 -
HPGGSDSILINAGTD NIA1_BRANA 574 -1 -
HPGGSDSILINAGTD NIA2_BRANA 574 -1 -
HPGGTDSILINAGTD NIA1_ARATH 580 -1 -
HPGGADSILINAGSD NIA1_HORVU 573 -1 -
HPGGIDSILINAGTD Q43042 576 -1 -
HPGGIDSILINAGTD NIA_PETHY 570 -1 -
HPGGTDRILINAGTD NIA1_SOYBN 548 -1 -
HPGGSDSILINAGTD NIA2_ARATH 577 -1 -
HPGGADSILINAGTD NIA_BETVE 563 -1 -
HPGGADSILINAGTD NIA3_MAIZE 555 -1 -
HPGGTDSILINAGTD NIA2_TOBAC 566 -1 -
HPGGSDSILINAGTD NIA1_TOBAC 566 -1 -
HPGGSDSILINAGTD NIA_SPIOL 586 -1 -
HPGGADSILINAGSD NIA7_HORVU 550 -1 -
HPGGSDSILLNAGTD NIA_CICIN 569 -1 -
HPGGVDSILINAGTD NIA_LYCES 571 -1 -
HPGGVDSILINAGTD O24390 571 -1 -
HPGGVDSILINAGTD O04926 571 -1 -
HPGGADSILLVAGTD Q42497 537 -1 -
HPGGEEVLREQAGGD CYB5_HORSE 43 -1 -
HPGGAASIFGAAGQD NIA_FUSOX 581 -1 -
HPGGAASIFGAAGQD Q92237 583 -1 -
HPGGEEVLREQAGGD CYB5_MOUSE 43 -1 -
HPGGEEVLREQAGGD CYB5_RAT 43 -1 -
HPGGEEVLREQAGGD O35768 44 -1 -
HPGGAQSIISAAGTD NIA_EMENI 547 -1 -
HPGGEEVLREQAGGD CYB5_HUMAN 43 -1 -
HPGGEEVLREQAGGD CYB5_BOVIN 43 -1 -
HPGGEEVLREQAGGD CYB5_PIG 43 -1 -
HPGGEEVLREQAGGD CYB5_RABIT 43 -1 -
HPGGEEVLREQAGGD P70116 44 -1 -
HPGGEEVLREQAGGD Q28726 44 -1 -
HPGGAQSIVSVAGLD O00101 570 -1 -
HPGGAQSIISAAGLD NIA_LEPMC 571 -1 -
HPGGSASIFGAAGQD O13486 572 -1 -
HPGGAASITGAAGQD NIA_NEUCR 652 -1 -
HPGGAQSIISSAGID NIA_ASPNG 549 -1 -
HPGGAESILIVAGAD NIA_VOLCA 532 -1 -
HPGGDDVLLSATGKD O04354 37 -1 -
HPGGEEVLREQAGGD CYB5_CHICK 49 -1 -
HPGGAISVTSSAGLD Q01696 546 -1 -
HPGGEEVLIEQAGKD CYB5_MUSDO 41 -1 -
HPGGDQSIVLSPGED NIA_USTMA 551 -1 -
HPGGAQSIISSAGLD Q12561 549 -1 -
HPGGRQSIISSAGQD Q00284 549 -1 -
HPGGATSILLCGGTD NIA_PHYIN 572 -1 -
HPGGATSIINAAAQD NIA_BEABA 570 -1 -
HPGGGEVLLSATGKD CYS5_TOBAC 40 -1 -
HPGGDEVLLSATGKD CYB5_TOBAC 40 -1 -
HPGGDDVLLSSTGKD O48845 40 -1 -
HPGGATSITGAAEDS Q00303 573 -1 -
HPGGDEVLLSSTGKD CYB5_BRAOL 40 -1 -
HPGGCEVLLEQAGSD Q93315 43 -1 -
HPGGADVLLSSTAKD CYB5_CUSRE 39 -1 -
HPGGDDVLLSSTGKD CYB5_ORYSA 41 -1 -
HPGGPEILLEFAGGD O17733 38 -1 -
HPGGHEVLVNVAGKD O76336 38 -1 -
HPGGAQSILMVSGED NIA_PICAN 538 -1 -
HPGGDEIIMDLGGQD CYB5_YEAST 37 -1 -
HPGGSRVISHYAGQD O60427 52 -1 -

Motif 3 width=8
Element Seqn Id St Int Rpt
CTEEFEAI NIA1_PHAVU 565 0 -
CTEEFDAI NIA_CUCMA 593 0 -
CTEEFEAI NIA2_SOYBN 567 0 -
CTEEFDAI NIA2_PHAVU 563 0 -
CTEEFEAI NIA_LOTJA 571 0 -
CTEEFDAI NIA1_ORYSA 591 0 -
CTEEFEAI NIA1_BRANA 589 0 -
CTEEFEAI NIA2_BRANA 589 0 -
CTEEFEAI NIA1_ARATH 595 0 -
CTEEFDAI NIA1_HORVU 588 0 -
CTEEFDAI Q43042 591 0 -
CTEEFDAI NIA_PETHY 585 0 -
CTEEFEAI NIA1_SOYBN 563 0 -
CTEEFEAI NIA2_ARATH 592 0 -
CTEEFDAI NIA_BETVE 578 0 -
CTEEFDAI NIA3_MAIZE 570 0 -
CTEEFDAI NIA2_TOBAC 581 0 -
CTEEFDAI NIA1_TOBAC 581 0 -
CTEEFDAI NIA_SPIOL 601 0 -
CTEEFDAI NIA7_HORVU 565 0 -
CTEEFDAI NIA_CICIN 584 0 -
CTEEFDAI NIA_LYCES 586 0 -
CTEEFDAI O24390 586 0 -
CTEEFDAI O04926 586 0 -
ATDEFNAI Q42497 552 0 -
ATENFEDI CYB5_HORSE 58 0 -
ATEEFMAI NIA_FUSOX 596 0 -
ATEEFMAI Q92237 598 0 -
ATENFEDV CYB5_MOUSE 58 0 -
ATENFEDV CYB5_RAT 58 0 -
ATENFEDV O35768 59 0 -
ASEEFLEI NIA_EMENI 562 0 -
ATENFEDV CYB5_HUMAN 58 0 -
ATENFEDV CYB5_BOVIN 58 0 -
ATENFEDV CYB5_PIG 58 0 -
ATENFEDV CYB5_RABIT 58 0 -
ATENFEDV P70116 59 0 -
ATENFEDV Q28726 59 0 -
ASDEFMAI O00101 585 0 -
ASDEFMAI NIA_LEPMC 586 0 -
VTEEFVTI O13486 587 0 -
VTDEFLAI NIA_NEUCR 667 0 -
VSEEFLAI NIA_ASPNG 564 0 -
ATDEFNSI NIA_VOLCA 547 0 -
ATDDFEDI O04354 52 0 -
ATENFEDV CYB5_CHICK 64 0 -
VSEDFLAI Q01696 561 0 -
ATEHFEDV CYB5_MUSDO 56 0 -
ATEDFMAI NIA_USTMA 567 1 -
VSEEFLAI Q12561 564 0 -
VSEEFLAI Q00284 564 0 -
CTDEFESI NIA_PHYIN 587 0 -
ATEEFMTI NIA_BEABA 585 0 -
ATDDFEDI CYS5_TOBAC 55 0 -
ATDDFEDV CYB5_TOBAC 55 0 -
ATDDFEDV O48845 55 0 -
STDEFMAI Q00303 587 -1 -
ATNDFEDV CYB5_BRAOL 55 0 -
GTEAFEDV Q93315 58 0 -
ATDDFEDI CYB5_CUSRE 54 0 -
ATDDFEDV CYB5_ORYSA 56 0 -
ATDAFESV O17733 53 0 -
ASEDFDDV O76336 53 0 -
ATDDFIAI NIA_PICAN 553 0 -
ATESFVDI CYB5_YEAST 52 0 -
ATDPFVAF O60427 67 0 -

Motif 4 width=13
Element Seqn Id St Int Rpt
AKKMLEDYRIGEL NIA1_PHAVU 577 4 -
AKKMLEDYRIGEL NIA_CUCMA 605 4 -
AKQMLEDYRIGEL NIA2_SOYBN 579 4 -
AKKMLEDYRIGEL NIA2_PHAVU 575 4 -
AKKMLEDYRVGEL NIA_LOTJA 583 4 -
AKALLDTYRIGEL NIA1_ORYSA 603 4 -
AKKLLEDYRIGEL NIA1_BRANA 601 4 -
AKKLLEDYRIGEL NIA2_BRANA 601 4 -
AKKLLEDYRIGEL NIA1_ARATH 607 4 -
AKALLDTYRIGEL NIA1_HORVU 600 4 -
AKKLLEDFRIGEL Q43042 603 4 -
AKKLLEDFRIGEL NIA_PETHY 597 4 -
AKQMLEDYRIGEL NIA1_SOYBN 575 4 -
AKKMLEDYRIGEL NIA2_ARATH 604 4 -
AKKMLEDYRIGEL NIA_BETVE 590 4 -
AKELLDTYRIGDL NIA3_MAIZE 582 4 -
AKKLLEDFRIGEL NIA2_TOBAC 593 4 -
AKKLLEEFRIGEL NIA1_TOBAC 593 4 -
AKRLLEDFRIGEL NIA_SPIOL 613 4 -
ARGLLEMYRVGEL NIA7_HORVU 577 4 -
AKKLLEEYRVGEL NIA_CICIN 596 4 -
AKKLLEDFRIGEL NIA_LYCES 598 4 -
AKKLLEDFRIGEL O24390 598 4 -
AKKLLEDFRIGEL O04926 598 4 -
AKKQLLEYYIGEL Q42497 564 4 -
ARELSKTFIIGEL CYB5_HORSE 71 5 -
AKAMLPTYHIGTL NIA_FUSOX 608 4 -
AKAMLPTYHIGTL Q92237 610 4 -
ARELSKTYIIGEL CYB5_MOUSE 71 5 -
ARELSKTYIIGEL CYB5_RAT 71 5 -
ARELSKTYIIGEL O35768 72 5 -
AKKMMPDYHIGTL NIA_EMENI 574 4 -
AREMSKTFIIGEL CYB5_HUMAN 71 5 -
ARELSKTFIIGEL CYB5_BOVIN 71 5 -
ARELSKTFIIGEL CYB5_PIG 71 5 -
ARELSKTFIIGEL CYB5_RABIT 71 5 -
ARELSKTFIIGEL P70116 72 5 -
ARELSKTFIIGEL Q28726 72 5 -
AKAMMPDYHIGSL O00101 597 4 -
AKAMMPAYHIGTL NIA_LEPMC 598 4 -
AKAMMPAYHIGKL O13486 599 4 -
AKAMMPTYHIGTL NIA_NEUCR 679 4 -
AKAMMPDYHIGTM NIA_ASPNG 576 4 -
AKAMLAQYYIGDL NIA_VOLCA 559 4 -
AKAMLDEYYVGDI O04354 65 5 -
ARALSETFIIGEL CYB5_CHICK 77 5 -
AKAMMPDYHIGTL Q01696 573 4 -
AREMMKQYKVGEL CYB5_MUSDO 69 5 -
AKKMLRDFHLGRL NIA_USTMA 579 4 -
AKAMMPEYHIGTM Q12561 576 4 -
AKAMMPEYHIGTT Q00284 576 4 -
AWQMLKKYCIGRC NIA_PHYIN 599 4 -
AKAMMPQYHIGTL NIA_BEABA 597 4 -
ARAMLDEYYVGDI CYS5_TOBAC 68 5 -
ARAMLDEYYVGDI CYB5_TOBAC 68 5 -
AREMMEQYYVGEI O48845 68 5 -
AKAMMPAYHIGTL Q00303 599 4 -
ARDMMEKYYIGEI CYB5_BRAOL 68 5 -
ARHMKDEYLIGEV Q93315 71 5 -
ARAMMDEMCVGDI CYB5_CUSRE 67 5 -
ARAMMDEYYVGDI CYB5_ORYSA 69 5 -
ARMMLTKFKIGSL O17733 66 5 -
AKELMKKYVVGEV O76336 66 5 -
AKKLLPSMHLGRL NIA_PICAN 565 4 -
ALRLLKGLYIGDV CYB5_YEAST 65 5 -
VKKYMNSLLIGEL O60427 81 6 -