| Literature References | 1. SUTTON, R.B., DAVLETOV, B.A., BERGHUIS, A.M., SUDHOF, T.C.
AND SPRANG, S.R.
Structure of the first C2 domain of synaptotagmin I: a novel
Ca2+/phospholipid-binding fold.
CELL 80 929-938 (1995).
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| Documentation | C2 domains are Ca2+-regulatory domains found widely in nature. To date,
more than 40 distinct C2 domains have been identified, for example in
proteins such as synaptotagmin, phospholipase A2, GTPase-activating
proteins, rabphilin and phospholipase C isoforms [1]. The domains show
no sequence similarity to other Ca2+-binding proteins; they thus
constitute a novel family of Ca2+-regulatory motifs, which also
includes members that have lost their calcium regulation.
The structure of C2 domains in synaptotagmin I has been deduced: the C2
polypeptide forms an 8-stranded beta-sandwich constructed around a
conserved 4-stranded motif, designated a C2 key [1]. Calcium binds in
a cup-shaped depression formed by the N- and C-terminal loops of the
C2-key motif.
C2DOMAIN is a 3-element fingerprint that provides a signature for C2
domains. The fingerprint was derived from an initial alignment of 12
sequences: the motifs were drawn from short conserved regions within
the C2-key core, corresponding to strands 3, 5 and 6 res., and including
3 of the 4 acidic residues involved in Ca2+ ligation. Three iterations on
OWL26.0 were required to reach convergence, at which point a true set
comprising 74 sequences was identified. Several partial matches were
also found, which was to be expected since the degree of sequence
divergence was high and the motifs therefore relatively short.
An update on SPTR37_9f identified a true set of 86 sequences, and 38
partial matches.
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| Sequence Titles | KPC1_DROME PROTEIN KINASE C, BRAIN ISOZYME (EC 2.7.1.-) (PKC) (DPKC53E(BR)) - DROSOPHILA MELANOGASTER (FRUIT FLY).
KPC1_HUMAN PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - HOMO SAPIENS (HUMAN).
KPC1_RABIT PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - ORYCTOLAGUS CUNICULUS (RABBIT).
KPC1_RAT PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - RATTUS NORVEGICUS (RAT).
KPC2_BOVIN PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - BOS TAURUS (BOVINE).
KPC2_DROME PROTEIN KINASE C, EYE ISOZYME (EC 2.7.1.-) (PKC) (DPKC53E(EY)) (PROTEIN INAC) (PHOTORECEPTOR-SPECIFIC PKC) (EYE-PKC) - DROSOPHILA MELANOGASTER (FRUIT FLY).
KPC2_HUMAN PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - HOMO SAPIENS (HUMAN).
KPC2_MOUSE PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
KPC2_RABIT PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - ORYCTOLAGUS CUNICULUS (RABBIT).
KPCA_BOVIN PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - BOS TAURUS (BOVINE).
KPCA_HUMAN PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - HOMO SAPIENS (HUMAN).
KPCA_MOUSE PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - MUS MUSCULUS (MOUSE).
KPCA_RABIT PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - ORYCTOLAGUS CUNICULUS (RABBIT).
KPCA_RAT PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - RATTUS NORVEGICUS (RAT).
KPCG_HUMAN PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) - HOMO SAPIENS (HUMAN).
KPCG_MOUSE PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
KPCG_RABIT PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) (DELTA) - ORYCTOLAGUS CUNICULUS (RABBIT).
O01715 PROTEIN KINASE C - HYDRA ATTENUATA (HYDRA) (HYDRA VULGARIS).
O14795 MUNC13 - HOMO SAPIENS (HUMAN).
O15755 R2005 - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
O16700 R12A1.2 PROTEIN - CAENORHABDITIS ELEGANS.
O17232 K10F12.3 PROTEIN - CAENORHABDITIS ELEGANS.
O17665 UNC-13 PROTEIN - CAENORHABDITIS ELEGANS.
O42573 NEDD4 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O43373 PAC CLONE DJ0897G10 FROM 7Q11.23-Q21.1, COMPLETE SEQUENCE - HOMO SAPIENS (HUMAN).
O43374 SIMILAR TO GTPASE-ACTIVATING PROTEINS - HOMO SAPIENS (HUMAN).
O48645 CLB1 - LYCOPERSICON ESCULENTUM (TOMATO).
O61224 SERINE/THREONINE PROTEIN KINASE - SYCON RAPHANUS.
O62567 SERINE/THREONINE PROTEIN KINASE - SUBERITES DOMUNCULA.
O73807 HYPOTHETICAL 109.2 KD PROTEIN - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
O75131 KIAA0636 PROTEIN - HOMO SAPIENS (HUMAN).
O76570 F54G2.1 PROTEIN - CAENORHABDITIS ELEGANS.
O76835 T12A2.15 PROTEIN - CAENORHABDITIS ELEGANS.
O76850 EYE-SPECIFIC PROTEIN KINASE C - CALLIPHORA VICINA (BLUE BLOWFLY) (CALLIPHORA ERYTHROCEPHALA).
O80558 T22J18.21 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P70169 DOC2BETA - MUS MUSCULUS (MOUSE).
P70610 DOC2A - RATTUS NORVEGICUS (RAT).
P70611 DOC2B - RATTUS NORVEGICUS (RAT).
P90980 PROTEIN KINASE C2 A ISOFORM - CAENORHABDITIS ELEGANS.
P90981 PROTEIN KINASE C2 B ISOFORM - CAENORHABDITIS ELEGANS.
P91199 SIMILARITY TO C2 DOMAINS - CAENORHABDITIS ELEGANS.
P92940 CALB PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P97791 SYNAPTOTAGMIN 3 - MUS MUSCULUS (MOUSE).
PIP6_HUMAN 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1 (EC 3.1.4.11) (PLC-DELTA-1) (PHOSPHOLIPASE C-DELTA-1) (PLC-III) - HOMO SAPIENS (HUMAN).
PIP6_RAT 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1 (EC 3.1.4.11) (PLC-DELTA-1) (PHOSPHOLIPASE C-DELTA-1) (PLC-III) - RATTUS NORVEGICUS (RAT).
PIPA_DICDI 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE (EC 3.1.4.11) (PLC) (PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C) - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
Q12466 CHROMOSOME XV READING FRAME ORF YOR086C - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q14183 DOC2 - HOMO SAPIENS (HUMAN).
Q14184 DOC2 BETA - HOMO SAPIENS (HUMAN).
Q15111 PHOSPHOLIPASE C - HOMO SAPIENS (HUMAN).
Q19025 SIMILAR TO PROTEIN KINASE C - CAENORHABDITIS ELEGANS.
Q20354 SIMILAR TO SYNAPTOTAGMIN - CAENORHABDITIS ELEGANS.
Q22413 HYPOTHETICAL 95.4 KD PROTEIN.
Q25378 PROTEIN KINASE C (EC 2.7.1.-) - LYTECHINUS PICTUS (PAINTED SEA URCHIN).
Q25393 SYNAPTOTAGMIN - LOLIGO PEALEII (LONGFIN SQUID).
Q62711 PHOSPHOLIPASE C DELTA-4 - RATTUS NORVEGICUS (RAT).
Q62746 SYNAPTOTAGMIN VI - RATTUS NORVEGICUS (RAT).
Q62768 MUNC13-1 - RATTUS NORVEGICUS (RAT).
Q62769 MUNC13-2 - RATTUS NORVEGICUS (RAT).
Q62770 MUNC13-3 - RATTUS NORVEGICUS (RAT).
Q63693 PHODPHOLIPASE C DELTA4 - RATTUS NORVEGICUS (RAT).
Q64048 PHOSPHOLIPASE C DELTA - RATTUS NORVEGICUS (RAT).
RP3A_BOVIN RABPHILIN-3A - BOS TAURUS (BOVINE).
RP3A_RAT RABPHILIN-3A - RATTUS NORVEGICUS (RAT).
SY61_DISOM SYNAPTOTAGMIN A (SYNAPTIC VESICLE PROTEIN O-P65-A) - DISCOPYGE OMMATA (ELECTRIC RAY).
SY62_DISOM SYNAPTOTAGMIN B (SYNAPTIC VESICLE PROTEIN O-P65-B) - DISCOPYGE OMMATA (ELECTRIC RAY).
SY63_DISOM SYNAPTOTAGMIN C (SYNAPTIC VESICLE PROTEIN O-P65-C) - DISCOPYGE OMMATA (ELECTRIC RAY).
SY65_APLCA SYNAPTOTAGMIN (P65) - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
SY65_DROME SYNAPTOTAGMIN (P65) - DROSOPHILA MELANOGASTER (FRUIT FLY).
SYT1_BOVIN SYNAPTOTAGMIN I (P65) - BOS TAURUS (BOVINE).
SYT1_CAEEL SYNAPTOTAGMIN I - CAENORHABDITIS ELEGANS.
SYT1_CHICK SYNAPTOTAGMIN I (P65) - GALLUS GALLUS (CHICKEN).
SYT1_HUMAN SYNAPTOTAGMIN I (P65) - HOMO SAPIENS (HUMAN).
SYT1_MOUSE SYNAPTOTAGMIN I (P65) - MUS MUSCULUS (MOUSE).
SYT1_RAT SYNAPTOTAGMIN I (P65) - RATTUS NORVEGICUS (RAT).
SYT2_MOUSE SYNAPTOTAGMIN II - MUS MUSCULUS (MOUSE).
SYT2_RAT SYNAPTOTAGMIN II - RATTUS NORVEGICUS (RAT).
SYT3_MOUSE SYNAPTOTAGMIN III (SYTIII) - MUS MUSCULUS (MOUSE).
SYT3_RAT SYNAPTOTAGMIN III - RATTUS NORVEGICUS (RAT).
SYT4_MOUSE SYNAPTOTAGMIN IV - MUS MUSCULUS (MOUSE).
SYT4_RAT SYNAPTOTAGMIN IV - RATTUS NORVEGICUS (RAT).
SYT5_HUMAN SYNAPTOTAGMIN V - HOMO SAPIENS (HUMAN).
SYT5_RAT SYNAPTOTAGMIN V - RATTUS NORVEGICUS (RAT).
UN13_CAEEL PHORBOL ESTER/DIACYLGLYCEROL-BINDING PROTEIN UNC-13 - CAENORHABDITIS ELEGANS.
YMH2_YEAST HYPOTHETICAL 171.1 KD PROTEIN IN RPL6A-DAK1 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YPT7_CAEEL HYPOTHETICAL 111.7 KD PROTEIN F37A4.7 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.
O00750 PHOSPHOINOSITIDE 3-KINASE (EC 2.7.1.137) (1-PHOSPHATIDYLINOSITOL 3-KINASE) (PHOSPHATIDYLINOSITOL 3-KINASE) (PI3-KINASE) (PTDINS-3-KINASE) - HOMO SAPIENS (HUMAN).
O04042 HYPOTHETICAL 71.0 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O04823 HYPOTHETICAL 18.8 KD PROTEIN - SPOROBOLUS STAPFIANUS.
O08758 NEDD-4 - MUS MUSCULUS (MOUSE).
O14111 PUTATIVE PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME C31G5.15 PRECURSOR (EC 4.1.1.65) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O17398 F52H2.7 PROTEIN - CAENORHABDITIS ELEGANS.
O48544 PHOSPHOLIPASE D-GAMMA (EC 3.1.4.4) (LIPOPHOSPHODIESTERASE II) (LECITHINASE D) (CHOLINE PHOSPHATASE) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O49557 HYPOTHETICAL 41.0 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O49951 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C (EC 3.1.4.11) (1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE) (TRIPHOSPHOINOSITIDE PHOSPHODIESTERASE) - SOLANUM TUBEROSUM (POTATO).
O50006 FUNGAL ELICITOR IMMEDIATE EARLY RESPONSIVE (OS-FIERG2) - ORYZA SATIVA (RICE).
O61957 B0348.3 PROTEIN - CAENORHABDITIS ELEGANS.
O65279 F6N23.8 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O75923 DYSFERLIN - HOMO SAPIENS (HUMAN).
O77793 CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE A2 (EC 3.1.1.4) (CPLA2) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE); LYSOPHOSPHOLIPASE (EC 3.1.1.5)] - EQUUS CABALLUS (HORSE).
P91493 SIMILAR TO THE C2 DOMAINS OF SYNAPTOTAGMINS - CAENORHABDITIS ELEGANS.
P97610 SRG1 - RATTUS NORVEGICUS (RAT).
PA2Y_BRARE CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE A2 (EC 3.1.1.4) (CPLA2) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE); LYSOPHOSPHOLIPASE (EC 3.1.1.5)] - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
PA2Y_CHICK CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE A2 (EC 3.1.1.4) (CPLA2) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE); LYSOPHOSPHOLIPASE (EC 3.1.1.5)] - GALLUS GALLUS (CHICKEN).
PA2Y_HUMAN CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE A2 (EC 3.1.1.4) (CPLA2) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE); LYSOPHOSPHOLIPASE (EC 3.1.1.5)] - HOMO SAPIENS (HUMAN).
PA2Y_MOUSE CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE A2 (EC 3.1.1.4) (CPLA2) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE); LYSOPHOSPHOLIPASE (EC 3.1.1.5)] - MUS MUSCULUS (MOUSE).
PA2Y_RAT CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE A2 (EC 3.1.1.4) (CPLA2) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE); LYSOPHOSPHOLIPASE (EC 3.1.1.5)] - RATTUS NORVEGICUS (RAT).
PIP4_BOVIN 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA 1 (EC 3.1.4.11) (PLC-GAMMA-1) (PHOSPHOLIPASE C-GAMMA-1) (PLC-II) (PLC-148) - BOS TAURUS (BOVINE).
PIP4_HUMAN 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA 1 (EC 3.1.4.11) (PLC-GAMMA-1) (PHOSPHOLIPASE C-GAMMA-1) (PLC-II) (PLC-148) - HOMO SAPIENS (HUMAN).
PIP4_RAT 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA 1 (EC 3.1.4.11) (PLC-GAMMA-1) (PHOSPHOLIPASE C-GAMMA-1) (PLC-II) (PLC-148) - RATTUS NORVEGICUS (RAT).
Q07723 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA 2A (EC 3.1.4.11) (PLC-BETA-2A) (PHOSPHOLIPASE C-BETA-2A) (PLC-IIA) (PLC-154) - BOS TAURUS (BOVINE).
Q07724 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA 2B (EC 3.1.4.11) (PLC-BETA-2B) (PHOSPHOLIPASE C-BETA-2B) (PLC-IIB) (PLC-154) - BOS TAURUS (BOVINE).
Q14644 INS P4-BINDING PROTEIN - HOMO SAPIENS (HUMAN).
Q15147 PHOSPHOLIPASE C BETA 4 - HOMO SAPIENS (HUMAN).
Q22366 HYPOTHETICAL 95.0 KD PROTEIN SIMILAR TO C2 DOMAIN OF PROTEIN KINASE C - CAENORHABDITIS ELEGANS.
Q22372 T10B10.5 PROTEIN - CAENORHABDITIS ELEGANS.
Q24284 PLC-GAMMA D - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q28013 R-RAS GTPASE ACTIVATING PROTEIN - BOS TAURUS (BOVINE).
Q60790 RAS P21 PROTEIN ACTIVATOR 3 (BRAIN-ENRICHED GTPASE-ACTIVATING PROTEIN GAPIII) - MUS MUSCULUS (MOUSE).
Q62688 130KDA-INS(1,4,5)P3 BINDING PROTEIN - RATTUS NORVEGICUS (RAT).
Q62747 SYNAPTOTAGMIN VII - RATTUS NORVEGICUS (RAT).
Q62807 B/K PROTEIN - RATTUS NORVEGICUS (RAT).
Q93602 F26D10.4.
YNI7_YEAST HYPOTHETICAL 132.5 KD PROTEIN IN TOP2-MKT1 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
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