Literature References | 1. NOMENCLATURE COMMITTEE OF THE INTERNATIONAL UNION OF BIOCHEMISTRY (NC-IUB).
Nomenclature of electron-transfer proteins. Recommendations 1989.
EUR.J.BIOCHEMISTRY 200 599-611 (1991).
2. NEBERT, D.W. AND GONZALEZ, F.J.
P450 genes: structure, evolution, and regulation.
ANNU.REV.BIOCHEMISTRY 56 945-993 (1987).
3. DEGTYARENKO, K.N. AND ARCHAKOV, A.I.
Molecular evolution of P450 superfamily and P450-containing monooxygenase
systems.
FEBS LETT. 332 1-8 (1993).
4. RUETTINGER, R.T., WEN, L.P. AND FULCO, A.J.
Coding nucleotide, 5' regulatory, and deduced amino acid sequences of
P-450BM-3, a single peptide cytochrome P-450:NADPH-P-450 reductase from
Bacillus megaterium.
J.BIOL.CHEM. 264 10987-10995 (1989).
5. NELSON, D.R., KAMATAKI, T., WAXMAN, D.J., GUENGERICH, F.P.,
ESTABROOK, R.W., FEYEREISEN, R., GONZALEZ, F.J., COON, M.J.,
GUNSALUS, I.C., GOTOH, O., OKUDA, K. AND NEBERT, D.W.
The P450 superfamily: update on new sequences, gene mapping, accession
numbers, early trivial names of enzymes, and nomenclature.
DNA CELL BIOL. 12 1-51 (1993).
6. KIZAWA, H., TOMURA, D., ODA, M., FUKAMIZU, A., HOSHINO, T., GOTOH, O.,
YASUI, T. AND SHOUN, H.
Nucleotide sequence of the unique nitrate/nitrite-inducible cytochrome
P-450 cDNA from Fusarium oxysporum.
J.BIOL.CHEM. 266 10632-10637 (1991).
7. POULOS, T.L., FINZEL, B.C. AND HOWARD, A.J.
High-resolution crystal structure of cytochrome P450cam.
J.MOL.BIOL. 195 687-700 (1987).
8. HASEMANN, C.A., RAVICHANDRAN, K.G., PETERSON, J.A. AND DEISENHOFER, J.
Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution.
J.MOL.BIOL. 236 1169-1185 (1994).
9. CUPP-VICKERY, J.R. AND POULOS, T.L.
Structure of cytochrome P450eryF involved in erythromycin biosynthesis.
NAT.STRUCT.BIOL. 2 144-153 (1995).
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Documentation | P450 enzymes constitute a superfamily of haem-thiolate proteins [1],
widely distributed in bacteria, fungi, plants and animals. The enzymes
are involved in metabolism of a plethora of both exogenous and endogenous
compounds [2]. Usually, they act as terminal oxidases in multicomponent
electron transfer chains, called P450-containing monooxygenase systems.
P450-containing monooxygenase systems primarily fall into 2 major classes:
bacterial/mitochondrial (type I), and microsomal (type II). Alternatively,
P450-containing systems can be classified according to the number of their
protein components [3]: mitochondrial and most bacterial P450 systems have
3 components - an FAD-containing flavoprotein (NADPH or NADH-dependent
reductase), an iron-sulphur protein, and P450; the eukaryotic microsomal
P450 system contains 2 components - NADPH:P450 reductase (a flavoprotein
containing both FAD and FMN) and P450; and a soluble monooxygenase P450BM-3
from Bacillus megaterium exists as a single polypeptide chain with 2
functional parts (the haem and flavin domains), and represents a unique
bacterial one-component system - sequence and functional comparisons show
that these domains are more similar to P450 and the flavoprotein of the
microsomal 2-component P450 monooxygenase system than to the relevant
proteins of the 3-component system [4].
Current P450 nomenclature, based on divergent evolution of the P450 super-
family, was proposed and developed by Nebert et al. [5]. But evolution of
P450s is not restricted to phylogeny; phylogenetic analysis can only be
applied to certain groups of orthologous genes (e.g. CYP1A1, 1A2, 2E1, 7,
11A1, 11B1, 17, 19, 21A1, 27 and 51). Some P450 gene clusters (e.g. the
mammalian CYP1A1 and CYP1A2, rat CYP2D cluster, house fly CYP6A and CYP6C
gene clusters, CYP13A cluster in Caenorhabditis elegans) have seemingly
appeared via gene duplication events and should be considered paralogous.
In P450 gene subfamilies such as CYP2A, 2B, 2C, 2D, 3A, 4A and 52A, which,
presumably, have arisen through numerous species-specific gene duplication
and conversion events, orthologue assignments are impossible. This kind of
evolution can be concerned with intraspecific specialisation. Gene fusion
events can lead to the appearance of a one-component P450 system. It has
been hypothesised that the Fusarium oxysporum P450nor (CYP55) gene is a
xenologous gene of prokaryotic origin [6]. Another example of a much more
ancient horizontal gene transfer event could be the integration of former
mitochondrial genes (families CYP11 and CYP27) into the nuclear genome.
Finally, convergent evolution cannot be ignored, such as witnessed in the
membrane-binding anchors or in the substrate-binding sites of P450 enzymes
from the different families, which have similar substrate specificity.
On the basis of sequence similarity, all P450s can be categorised into 2
main groups, the so-called B- and E-classes: P450 proteins of prokaryotic
3-component systems and fungal P450nor (CYP55) belong to the B-class; all
other known P450s from distinct systems are of the E-class. The data
suggest that divergence of the P450 superfamily into B- and E-classes, and
further divergence into stable P450 groups within the E-class, must be very
ancient and had occured before the appearance of eukaryotes.
By contrast with the E-class, which mainly consists of multigenic families,
most families in the B-class are presented by the unique known sequence.
Exceptions are families CYP105 (5 subfamilies), CYP107 (6 subfamilies)
and CYP113 (2 subfamilies); only CYP105A and CYP106A subfamilies contain
2 different genes.
To date, the 3D structures of 4 P450s have been reported, 3 of which belong
to the B-class: P450cam [7], P450terp [8] and P450eryF [9]. The P450
molecule is an alpha/beta protein, shaped like a triangular prism; the
overall structure can be roughly divided into alpha-rich (`right side') and
beta-rich (`left side') domains [7-9]. However, this division appears to be
artificial since the alpha- and beta-rich domains comprise discontinuous
assemblies of secondary structure segments and do not constitute independent
folding units. Although the sequence identity between any 2 P450s with known
3D structure reaches only 20% or less, the overall topology of the proteins
is similar, with some differences in the orientations of various helices.
The most dramatic variations between P450 structures are found in regions
responsible for substrate binding and access.
BP450 is a 9-element fingerprint that provides a signature for B-class
P450s. The fingerprint was derived from an initial alignment of 20
sequences: the motifs were drawn from the most conserved regions of the
alignment - motif 1 includes the N-terminal part of the C helix; motifs 2
and 3 are adjacent and span the E helix and the major part of the F helix;
motif 4 includes the C-terminal half of the G helix and the entire H helix;
motif 5 corresponds to the K helix (cf. motif 3 of signature P450); motifs
6 and 7 span strands 3 and 4, the 3-10 helix of P450cam (the K' helix in
P450 terp [8]) and the neighbouring loop region; motifs 8 and 9 are
adjacent, spanning the invariant Cys residue, which provides the haem iron
thiolate ligand (cf. PROSITE pattern CYTOCHROME_P450 (PS00086) and motifs
4 and 5 of signature P450) - motif 9 spans the N-terminus of the L helix
(nb. in the B-class P450s, the regions corresponding to motifs 1 and 2 of
signature P450 are not sufficiently conserved to be used in the fingerprint,
although at the structural level, the I and J helices are well conserved in
all known crystal structures [7-9]). Two iterations on OWL26.0 were required
to reach convergence, at which point a true set comprising 23 sequences was
identified. Several partial matches were also found, several of which are
P450 sequences matching 5 motifs; most of the sequences matching only 2
motifs are noise. Among the partial matches, 2 bacterial P450 sequences
were found: a hypothetical product of CYP117 gene from Bradyrhizobium
japonicum (BJU126785), matching motifs 3, 6, 8 and 9; and nitrogen fixation-
associated gene CYP110 from Anabaena sp., which matches only motifs 5 and 9.
An update on SPTR37_9f identified a true set of 45 sequences, and 255
partial matches.
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Sequence Titles | BIOI_BACSU BIOTIN BIOSYNTHESIS; CYTOCHROME P450-LIKE ENZYME (EC 1.14.-.-) - BACILLUS SUBTILIS. CPXE_STRGO CYTOCHROME P450-SU1 (EC 1.14.-.-) (P450-CVA1) (CYP105A1) - STREPTOMYCES GRISEOLUS. CPXF_STRGO CYTOCHROME P450-SU2 (EC 1.14.-.-) (P450-CVB1) (CYP105B1) - STREPTOMYCES GRISEOLUS. CPXH_STRGR CYTOCHROME P450-SOY (EC 1.14.-.-) - STREPTOMYCES GRISEUS. CPXI_BACME CYTOCHROME P450(BM-1) (EC 1.14.14.1) - BACILLUS MEGATERIUM. CPXJ_SACER 6-DEOXYERYTHRONOLIDE B HYDROXYLASE (EC 1.-.-.-) (6-DEB HYDOXYLASE) (ERYTHOMYCIN A BIOSYNTHESIS HYDROLASE) (CYTOCHROME P450 107A1) (CYPCVIIA1) - SACCHAROPOLYSPORA ERYTHRAEA (STREPTOMYCES ERYTHRAEUS). CPXK_SACER CYTOCHROME P450 107B1 (EC 1.14.-.-) (P450CVIIB1) - SACCHAROPOLYSPORA ERYTHRAEA (STREPTOMYCES ERYTHRAEUS). CPXL_PSESP CYTOCHROME P450-TERP (EC 1.14.-.-) (CYTOCHROME P450 108) - PSEUDOMONAS SP. CPXM_BACME CYTOCHROME P450(MEG) (EC 1.14.99.-) (STEROID 15-BETA-HYDROXYLASE) (STEROID 15-BETA-MONOOXYGENASE) - BACILLUS MEGATERIUM. CPXM_BACSU CYTOCHROME P450 109 (EC 1.14.-.-) (ORF405) - BACILLUS SUBTILIS. CPXP_BRAJA CYTOCHROME P450 BJ-1 (EC 1.14.14.-) (CYTOCHROME P450 112) - BRADYRHIZOBIUM JAPONICUM. CPXP_RHISN CYTOCHROME P450 BJ-1 HOMOLOG (EC 1.14.14.-) - RHIZOBIUM SP. (STRAIN NGR234). CPXQ_SACER CYTOCHROME P450 113A1 (ERYTHROMYCIN B/D C-12 HYDROXYLASE) - SACCHAROPOLYSPORA ERYTHRAEA (STREPTOMYCES ERYTHRAEUS). CPXR_BRAJA CYTOCHROME P450 BJ-3 (EC 1.14.14.-) (CYTOCHROME P450 114) - BRADYRHIZOBIUM JAPONICUM. CPXR_RHISN CYTOCHROME P450 BJ-3 HOMOLOG (EC 1.14.14.-) - RHIZOBIUM SP. (STRAIN NGR234). CPXY_BACSU CYTOCHROME P450 (EC 1.14.-.-) - BACILLUS SUBTILIS. FAS1_RHOFA CYTOCHROME P450 FAS1 (EC 1.14.-.-) - RHODOCOCCUS FASCIANS. NOR1_CYLTO CYTOCHROME P450 55A2 (EC 1.14.-.-) (CYTOCHROME P450NOR1) - CYLINDROCARPON TONKINENSE. NOR2_CYLTO CYTOCHROME P450 55A3 (EC 1.14.-.-) (CYTOCHROME P450NOR2) - CYLINDROCARPON TONKINENSE. NOR_FUSOX CYTOCHROME P450 55A1 (EC 1.14.-.-) (CYPLVA1) (P450 DNIR) (NITRIC-OXIDE REDUCTASE) (P450 NOR) - FUSARIUM OXYSPORUM. O08464 CYTOCHROME P450 (EC 1.14.14.1) - MYCOBACTERIUM TUBERCULOSIS. O31785 HYDROXYLASE OF THE POLYKETIDE PRODUCED BY THE PKS CLUSTER - BACILLUS SUBTILIS. O32460 ORF 10 - ACTINOMADURA HIBISCA. O33180 PROBABLE CYTOCHROME P450 - MYCOBACTERIUM TUBERCULOSIS. O34374 P450 HEME-THIOLATE PROTEIN - BACILLUS SUBTILIS. O52544 CYTOCHROME P450 MONOOXYGENASE - AMYCOLATOPSIS MEDITERRANEI. O52561 CYTOCHROME P450 MONOOXYGENASE - AMYCOLATOPSIS MEDITERRANEI. O52823 PCZA363.7 - AMYCOLATOPSIS ORIENTALIS. O53563 PUTATIVE CYTOCHROME P450 MONOXYGENASE - MYCOBACTERIUM TUBERCULOSIS. O85697 PUTATIVE CYTOCHROME P450 OXIDOREDUCTASE - STREPTOMYCES LIVIDANS. O87192 ORF-2 PROTEIN - STREPTOMYCES GRISEUS. O87605 CYTOCHROME P450 MONOOXYGENASE - STREPTOMYCES VIOLACEUS (STREPTOMYCES VENEZUELAE), AND STREPTOMYCES VENEZUELAE. O87674 OXYGENASE B - AMYCOLATOPSIS MEDITERRANEI. O87675 OXYGENASE C - AMYCOLATOPSIS MEDITERRANEI. P71856 HYPOTHETICAL 48.4 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS. P77902 PROBABLE CYTOCHROME P450 CY369.11C (EC 1.14.14.1) - MYCOBACTERIUM TUBERCULOSIS. Q54302 CYTOCHROME P450 - STREPTOMYCES HYGROSCOPICUS. Q59523 CYTOCHROME P450-LIKE PROTEIN (EC 1.14.14.1) - MICROMONOSPORA GRISEORUBIDA. Q59723 CYTOCHROME P450 LIN (EC 1.14.14.1) - PSEUDOMONAS INCOGNITA. Q59819 CYTOCHROME P450 (EC 1.14.14.1) - STREPTOMYCES ANTIBIOTICUS. Q59831 CYTOCHROME P450 SCA-2 (EC 1.14.14.1) - STREPTOMYCES CARBOPHILUS. Q59910 CYTOCHROME P450 (EC 1.14.14.1) - STREPTOMYCES FRADIAE. Q60005 PUTATIVE CYTOCHROME P-450 PROTEIN (EC 1.14.14.1) (UNSPECIFIC MONOOXYGENASE) (MICROSOMAL MONOOXYGENASE) (XENOBIOTIC MONOOXYGENASE) (ARYL-4-MONOOXYGENASE) (ARYL HYDROCARBON HYDROXYLASE) (MICROSOMAL P450) (FLAVOPROTEIN-LINKED MONOOXYGENASE) (CYTOCHROME P450) - STREPTOMYCES THERMOTOLERANS. YP22_MYCTU PUTATIVE CYTOCHROME P450 CY369.22 (EC 1.14.-.-) - MYCOBACTERIUM TUBERCULOSIS. YU44_MYCTU PUTATIVE CYTOCHROME P450 CY339.44C (EC 1.14.-.-) - MYCOBACTERIUM TUBERCULOSIS. CPXC_AGRT6 CYTOCHROME P450-PINF1, PLANT-INDUCIBLE (EC 1.14.-.-) - AGROBACTERIUM TUMEFACIENS. CPXG_STRSQ CYTOCHROME P450 105C1 (EC 1.14.-.-) - STREPTOMYCES SP. CPXW_SULSO PROBABLE CYTOCHROME P450 119 (EC 1.14.14.-) - SULFOLOBUS SOLFATARICUS. O24727 HYPOTHETICAL 43.4 KD PROTEIN - NOCARDIOIDES SP. (STRAIN KP7). O52560 CYTOCHROME P450 MONOOXYGENASE - AMYCOLATOPSIS MEDITERRANEI. Q59921 CYTOCHROME P450 (EC 1.14.14.1) - STREPTOMYCES HYGROSCOPICUS. THCB_RHOSO CYTOCHROME P450 116 (EC 1.14.-.-) - RHODOCOCCUS SP. (STRAIN NI86/21). Y08Q_MYCTU PUTATIVE CYTOCHROME P450 CY50.26 (EC 1.14.-.-) - MYCOBACTERIUM TUBERCULOSIS. YU42_MYCTU PUTATIVE CYTOCHROME P450 CY339.42 (EC 1.14.-.-) - MYCOBACTERIUM TUBERCULOSIS. CPXA_PSEPU CYTOCHROME P450-CAM (EC 1.14.15.1) (CAMPHOR 5-MONOOXYGENASE) - PSEUDOMONAS PUTIDA. O50242 P-450 MONOOXYGENASE - AGROBACTERIUM TUMEFACIENS. O52572 CYTOCHROME P450 MONOOXYGENASE - AMYCOLATOPSIS MEDITERRANEI. O52802 PCZA361.17 - AMYCOLATOPSIS ORIENTALIS. P77977 CYTOCHROME P450 (EC 1.14.14.1) - STREPTOMYCES SP. Q59971 CYTOCHROME P450 (DAUNOMYCIN C-14 HYDROXYLASE) (EC 1.14.14.1) - STREPTOMYCES SP. O08362 HYPOTHETICAL 43.7 KD PROTEIN (EC 1.14.14.1) - MYCOBACTERIUM TUBERCULOSIS. O50243 P-450 MONOXYGENASE - AGROBACTERIUM TUMEFACIENS. O53936 PUTATIVE CYTOCHROME P450 - MYCOBACTERIUM TUBERCULOSIS. Q59079 VITAMIN D3 25-HYDROXYLASE (EC 1.14.-.-) - AMYCOLATA AUTOTROPHICA. Y4VG_RHISN PROBABLE CYTOCHROME P450 Y4VG (EC 1.14.14.-) - RHIZOBIUM SP. (STRAIN NGR234). C883_ARATH CYTOCHROME P450 88A3 (EC 1.14.-.-) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). CPXD_AGRT6 CYTOCHROME P450-PINF2, PLANT-INDUCIBLE (EC 1.14.-.-) - AGROBACTERIUM TUMEFACIENS. O34926 CYPB - BACILLUS SUBTILIS. O52822 PCZA363.6 - AMYCOLATOPSIS ORIENTALIS. O87673 OXYGENASE A - AMYCOLATOPSIS MEDITERRANEI. C881_MAIZE CYTOCHROME P450 88A1 (EC 1.14.-.-) (DWARF3 PROTEIN) - ZEA MAYS (MAIZE). CPN1_PIG CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P450C11) (STEROID 11-BETA-HYDROXYLASE) - SUS SCROFA (PIG). CPN2_MOUSE CYTOCHROME P450 11B2 PRECURSOR (EC 1.14.15.4) (CYPXIB2) (P450C11) (STEROID 11-BETA-HYDROXYLASE) (ALDOSTERONE SYNTHASE) - MUS MUSCULUS (MOUSE). Q54823 DNRP - STREPTOMYCES PEUCETIUS. Q64539 CYTOCHROME P450 11-BETA (EC 1.14.14.1) - RATTUS NORVEGICUS (RAT). Q64546 CYTOCHROME P450 C11B3 (EC 1.14.14.1) - RATTUS NORVEGICUS (RAT). Q64586 CYTOCHROME P450 (STEROID 11-BETA-HYDROXYLASE) (EC 1.14.14.1) - RATTUS NORVEGICUS (RAT). YU34_MYCTU PUTATIVE CYTOCHROME P450 CY339.34C (EC 1.14.-.-) - MYCOBACTERIUM TUBERCULOSIS. AVNA_ASPPA AVERANTIN OXIDOREDUCTASE (EC 1.14.-.-) (CYTOCHROME P450 60A1) - ASPERGILLUS PARASITICUS. CP09_MYCTU CYTOCHROME P450 51-LIKE RV3059 (EC 1.14.-.-) - MYCOBACTERIUM TUBERCULOSIS. CP10_LYMST CYTOCHROME P450 10 (EC 1.14.-.-) (CYPX) - LYMNAEA STAGNALIS (GREAT POND SNAIL). CP2B_HUMAN 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-) (25-OHD-1 ALPHA-HYDROXYLASE) (25-HYDROXYVITAMIN D3 1- ALPHA-HYDROXYLASE) (VD3 1A HYDROXYLASE) (P450C1 ALPHA) (P450VD1- ALPHA) - HOMO SAPIENS (HUMAN). CP2B_MOUSE 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-) (25-OHD-1 ALPHA-HYDROXYLASE) (25-HYDROXYVITAMIN D3 1- ALPHA-HYDROXYLASE) (VD3 1A HYDROXYLASE) (P450C1 ALPHA) (P450VD1- ALPHA) - MUS MUSCULUS (MOUSE). CP2B_RAT 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-) (25-OHD-1 ALPHA-HYDROXYLASE) (25-HYDROXYVITAMIN D3 1- ALPHA-HYDROXYLASE) (VD3 1A HYDROXYLASE) (P450C1 ALPHA) (P450VD1- ALPHA) - RATTUS NORVEGICUS (RAT). CP36_RABIT Cytochrome P450 3A6 (EC 1.14.14.1) (CYPIIIA6) (P450-3C) - Oryctolagus cuniculus (Rabbit). CP3T_PIG Cytochrome P450 3A29 (EC 1.14.14.1) (CYPIIIA29) - Sus scrofa (Pig). CPCB_RAT CYTOCHROME P450 2C11 (EC 1.14.14.1) (CYPIIC11) (P-450(M-1)) (P450H) (P450-UT-A) (UT-2) - RATTUS NORVEGICUS (RAT). CPCM_RAT CYTOCHROME P450 2C22 (EC 1.14.14.1) (CYPIIC22) (P450 MD) (P450 P49) - RATTUS NORVEGICUS (RAT). CPCT_MOUSE CYTOCHROME P450 2C29 (EC 1.14.14.1) (CYPIIC29) (P-450 MUT-2) (ALDEHYDE OXYGENASE) - MUS MUSCULUS (MOUSE). CPCU_RABIT CYTOCHROME P450 2C30 (EC 1.14.14.1) (CYPIIC30) - ORYCTOLAGUS CUNICULUS (RABBIT). CPM1_HUMAN CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6) (CYPXIA1) (P450(SCC)) (CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME) (CHOLESTEROL DESMOLASE) - HOMO SAPIENS (HUMAN). CPM1_RAT CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6) (CYPXIA1) (P450(SCC)) (CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME) (CHOLESTEROL DESMOLASE) - RATTUS NORVEGICUS (RAT). CPN1_HUMAN CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P450C11) (STEROID 11-BETA-HYDROXYLASE) - HOMO SAPIENS (HUMAN). CPN1_PAPHA CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P450C11) (STEROID 11-BETA-HYDROXYLASE) - PAPIO HAMADRYAS (HAMADRYAS BABOON). CPN1_RAT CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P450C11) (STEROID 11-BETA-HYDROXYLASE) (P450(11 BETA)-DS) - RATTUS NORVEGICUS (RAT). CPN2_HUMAN CYTOCHROME P450 11B2 PRECURSOR (EC 1.14.15.4) (CYPXIB2) (P-450ALDO) (ALDOSTERONE SYNTHASE) (ALDOS) (ALDOSTERONE-SYNTHESIZING ENZYME) (STEROID 18-HYDROXYLASE) (P-450C18) - HOMO SAPIENS (HUMAN). CPN2_MESAU CYTOCHROME P450 11B2 PRECURSOR (EC 1.14.15.4) (C450XIB2) (ALDOSTERONE SYNTHASE) (P-450ALDO) (ALDOS) (ALDOSTERONE-SYNTHESIZING ENZYME) (STEROID 18-HYDROXYLASE) (P-450C18) - MESOCRICETUS AURATUS (GOLDEN HAMSTER). CPN2_RAT CYTOCHROME P450 11B2 PRECURSOR (EC 1.14.15.4) (CYPXIB2) (P450-ALDO-1) (ALDOSTERONE SYNTHASE) - RATTUS NORVEGICUS (RAT). CPN3_RAT CYTOCHROME P450 11B3 PRECURSOR (EC 1.14.15.4) (CYPXIB3) (P450-ALDO-2) (ALDOSTERONE SYNTHASE) - RATTUS NORVEGICUS (RAT). CPT7_CHICK CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - GALLUS GALLUS (CHICKEN). CPT7_ONCMY CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI). CPT7_ORYLA CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - ORYZIAS LATIPES (MEDAKA FISH). CPT7_SQUAC CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - SQUALUS ACANTHIAS (SPINY DOGFISH). CPXU_RHISN CYTOCHROME P450 BJ-4 HOMOLOG (EC 1.14.14.-) - RHIZOBIUM SP. (STRAIN NGR234). O08447 PUTATIVE CYTOCHROME P450 MONOXYGENASE (EC 1.14.14.1) - MYCOBACTERIUM TUBERCULOSIS. O13254 CYTOCHROME P450 SCC (EC 1.14.14.1) - GALLUS GALLUS (CHICKEN). O13820 PUTATIVE CYTOCHROME P450 C19A8.04 IN CHROMOSOME I (EC 1.14.-.-) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). O16156 CYTOCHROME P450 30 - MERCENARIA MERCENARIA (NORTHERN QUAHOG). O16482 SIMILAR TO CYTOCHROME P450 - CAENORHABDITIS ELEGANS. O16670 F41B5.4 PROTEIN - CAENORHABDITIS ELEGANS. O16672 F41B5.7 PROTEIN - CAENORHABDITIS ELEGANS. O17655 C41G6.1 PROTEIN - CAENORHABDITIS ELEGANS. O33934 ERYCII - SACCHAROPOLYSPORA ERYTHRAEA (STREPTOMYCES ERYTHRAEUS). O44655 B0213.10 PROTEIN - CAENORHABDITIS ELEGANS. O44658 B0213.14 PROTEIN - CAENORHABDITIS ELEGANS. O45317 Y17D7A.4 PROTEIN - CAENORHABDITIS ELEGANS. O45659 K05D4.4 PROTEIN - CAENORHABDITIS ELEGANS. O46515 CYTOCHROME P450 CHOLESTEROL SIDE-CHAIN CLEAVAGE - EQUUS CABALLUS (HORSE). O54225 DTDP-4-KETO-6-DEOXY-HEXOSE 3,4-ISOMERASE - SACCHAROPOLYSPORA ERYTHRAEA (STREPTOMYCES ERYTHRAEUS). O65624 CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O69653 PUTATIVE CYTOCHROME P-450 - MYCOBACTERIUM TUBERCULOSIS. O81077 PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O86330 HYPOTHETICAL 47.9 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS. O87829 CYTOCHROME P450 MONOOXYGENASE - STREPTOMYCES ANTIBIOTICUS. P95099 HYPOTHETICAL 56.2 KD PROTEIN (EC 1.14.14.1) - MYCOBACTERIUM TUBERCULOSIS. Q27465 SIMILAR TO CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS ELEGANS. Q27470 SIMILAR TO CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS ELEGANS. Q27482 SIMILAR TO CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS ELEGANS. THAS_PIG THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) - SUS SCROFA (PIG). THAS_RAT THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) - RATTUS NORVEGICUS (RAT). C2F1_HUMAN CYTOCHROME P450 2F1 (EC 1.14.14.1) (CYPIIF1) - HOMO SAPIENS (HUMAN). C2F2_MOUSE CYTOCHROME P450 2F2 (EC 1.14.14.-) (CYPIIF2) (NAPHTHALENE DEHYDROGENASE) (NAPHTHALENE HYDROXYLASE) (P450-NAH-2) - MUS MUSCULUS (MOUSE). C4D1_DROME CYTOCHROME P450 4D1 (EC 1.14.14.1) (CYPIVD1) - DROSOPHILA MELANOGASTER (FRUIT FLY). C4D1_DROSI CYTOCHROME P450 4D1 (EC 1.14.14.1) (CYPIVD1) - DROSOPHILA SIMULANS (FRUIT FLY). C4D2_DROME CYTOCHROME P450 4D2 (EC 1.14.14.1) (CYPIVD2) - DROSOPHILA MELANOGASTER (FRUIT FLY). C718_MENPI CYTOCHROME P450 71A8 (EC 1.14.-.-) - MENTHA PIPERITA (PEPPERMINT). C755_EUSGR FLAVONOID 3',5'-HYDROXYLASE (EC 1.14.-.-) (F3'5'H) (CYTOCHROME P450 75A5) - EUSTOMA GRANDIFLORUM (BLUEBELLS) (LISIANTHUS RUSSELLIANUS). C756_CAMME FLAVONOID 3',5'-HYDROXYLASE (EC 1.14.-.-) (F3'5'H) (CYTOCHROME P450 75A6) - CAMPANULA MEDIUM (CANTERBURY BELLS). C757_EUSGR FLAVONOID 3',5'-HYDROXYLASE (EC 1.14.-.-) (F3'5'H) (CYTOCHROME P450 75A7) - EUSTOMA GRANDIFLORUM (BLUEBELLS) (LISIANTHUS RUSSELLIANUS). C772_SOLME CYTOCHROME P450 77A2 (EC 1.14.-.-) (CYPLXXVIIA2) (P-450EG5) - SOLANUM MELONGENA (EGGPLANT) (AUBERGINE). C7E1_SORBI CYTOCHROME P450 71E1 (EC 1.14.-.-) - SORGHUM BICOLOR MILO (SORGHUM). C823_SOYBN CYTOCHROME P450 82A3 (EC 1.14.-.-) (P450 CP6) - GLYCINE MAX (SOYBEAN). C824_SOYBN CYTOCHROME P450 82A4 (EC 1.14.-.-) (P450 CP9) - GLYCINE MAX (SOYBEAN). C861_ARATH CYTOCHROME P450 86A1 (EC 1.14.-.-) (CYPLXXXVI) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). C892_ARATH CYTOCHROME P450 89A2 (EC 1.14.-.-) (CYPLXXXIX) (ATH 6-1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). C931_SOYBN CYTOCHROME P450 93A1 (EC 1.14.-.-) - GLYCINE MAX (SOYBEAN). C932_SOYBN CYTOCHROME P450 93A2 (EC 1.14.-.-) - GLYCINE MAX (SOYBEAN). C933_SOYBN CYTOCHROME P450 93A3 (EC 1.14.-.-) (P450 CP5) - GLYCINE MAX (SOYBEAN). CP18_DROME CYTOCHROME P450 18 (EC 1.14.14.-) (CYPXVIII) - DROSOPHILA MELANOGASTER (FRUIT FLY). CP27_HUMAN STEROL 26-HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-) (VITAMIN D(3) 25-HYDROXYLASE) (5-BETA-CHOLESTANE-3-ALPHA,7-ALPHA,12-ALPHA-TRIOL 27-HYDROXYLASE) - HOMO SAPIENS (HUMAN). CP27_RABIT STEROL 26-HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-) (VITAMIN D(3) 25-HYDROXYLASE) (5-BETA-CHOLESTANE-3-ALPHA,7-ALPHA,12-ALPHA-TRIOL 27-HYDROXYLASE) - ORYCTOLAGUS CUNICULUS (RABBIT). CP27_RAT STEROL 26-HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-) (VITAMIN D(3) 25-HYDROXYLASE) (5-BETA-CHOLESTANE-3-ALPHA,7-ALPHA,12-ALPHA-TRIOL 27-HYDROXYLASE) - RATTUS NORVEGICUS (RAT). CP31_RAT Cytochrome P450 3A1 (EC 1.14.14.1) (CYPIIIA1) (P450-PCN1) - Rattus norvegicus (Rat). CP33_HUMAN Cytochrome P450 3A3 (EC 1.14.14.1) (CYPIIIA3) (HLp) - Homo sapiens (Human). CP34_HUMAN Cytochrome P450 3A4 (EC 1.14.14.1) (CYPIIIA4) (Nifedipine oxidase) (NF-25) (P450-PCN1) - Homo sapiens (Human). CP39_RAT Cytochrome P450 3A9 (EC 1.14.14.1) (CYPIIIA9) (P450-OLF3) (Olfactive) (3AH15) - Rattus norvegicus (Rat). CP3A_MESAU Cytochrome P450 3A10 (EC 1.14.14.1) (CYPIIIA10) (6 beta-hydroxylase) - Mesocricetus auratus (Golden hamster). CP3C_CANFA Cytochrome P450 3A12 (EC 1.14.14.1) (CYPIIIA12) (P450-PBD-1) - Canis familiaris (Dog). CP3D_MOUSE Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13) - Mus musculus (Mouse). CP3E_CAVPO Cytochrome P450 3A14 (EC 1.14.14.1) (CYPIIIA14) - Cavia porcellus (Guinea pig). CP3O_SHEEP Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) - Ovis aries (Sheep). CP3R_ONCMY Cytochrome P450 3A27 (EC 1.14.14.1) (CYPIIIA27) - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri). CP51_CANAL CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STEROL 14- ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM) - CANDIDA ALBICANS (YEAST). CP51_CANGA CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STEROL 14- ALPHA-DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM) - CANDIDA GLABRATA (YEAST) (TORULOPSIS GLABRATA). CP51_PENIT CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STEROL 14- ALPHA DEMETHYLASE) (EBURICOL 14-ALPHA-DEMETHYLASE) (P450-14DM) - PENICILLIUM ITALICUM. CP51_SCHPO PROBABLE CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). CP51_UNCNE CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STEROL 14- ALPHA DEMETHYLASE) (EBURICOL 14-ALPHA-DEMETHYLASE) (P450-14DM) - UNCINULA NECATOR (GRAPE POWDERY MILDEW). CP51_USTMA CYTOCHROME P450 51 (EC 1.14.14.1) (CYPL1) (P450-L1A1) (STEROL 14- ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM) - USTILAGO MAYDIS (SMUT FUNGUS). CP74_ARATH ALLENE OXIDE SYNTHASE PRECURSOR (EC 4.2.1.92) (HYDROPEROXIDE DEHYDRASE) (CYTOCHROME P450 74A) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). CP74_LINUS ALLENE OXIDE SYNTHASE PRECURSOR (EC 4.2.1.92) (HYDROPEROXIDE DEHYDRASE) (CYTOCHROME P450 74A) - LINUM USITATISSIMUM (FLAX) (LINSEED). CPA3_RAT Cytochrome P450 2A3 (EC 1.14.14.1) (CYPIIA3) (Coumarin 7-hydroxylase) - Rattus norvegicus (Rat). CPA4_MOUSE Cytochrome P450 2A4 (EC 1.14.14.1) (CYPIIA4) (Testosterone 15-alpha- hydroxylase) (P450-15-alpha) (P450-IIA3.1) - Mus musculus (Mouse). CPA5_MOUSE Cytochrome P450 2A5 (EC 1.14.14.1) (CYPIIA5) (Coumarin 7-hydroxylase) (P450-15-COH) (P450-IIA3.2) - Mus musculus (Mouse). CPA6_HUMAN Cytochrome P450 2A6 (EC 1.14.14.1) (CYPIIA6) (Coumarin 7-hydroxylase) (IIA3) (CYP2A3) (P450(I)) - Homo sapiens (Human). CPA7_HUMAN Cytochrome P450 2A7 (EC 1.14.14.1) (CYPIIA7) (P450-IIA4) - Homo sapiens (Human). CPAB_RABIT Cytochrome P450 2A11 (EC 1.14.14.1) (CYPIIA11) (P450-IIA11) - Oryctolagus cuniculus (Rabbit). CPB9_MOUSE Cytochrome P450 2B9 (EC 1.14.14.1) (CYPIIB9) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF26) - Mus musculus (Mouse). CPBA_MOUSE Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF3/46) - Mus musculus (Mouse). CPBB_CANFA Cytochrome P450 2B11 (EC 1.14.14.1) (CYPIIB11) (P450 PBD-2) - Canis familiaris (Dog). CPC2_RABIT CYTOCHROME P450 2C2 (EC 1.14.14.1) (CYPIIC2) (P450 PBC2) (PHP2) (LAURATE OMEGA-1 HYDROXYLASE) - ORYCTOLAGUS CUNICULUS (RABBIT). CPC3_RABIT CYTOCHROME P450 2C3 (EC 1.14.14.1) (CYPIIC3) (P450 PBC3) (P450 FORM 3B) - ORYCTOLAGUS CUNICULUS (RABBIT). CPC4_RABIT CYTOCHROME P450 2C4 (EC 1.14.14.1) (CYPIIC4) (PROGESTERONE 21- HYDROXYLASE) (P450 PBC4) (P1-88) - ORYCTOLAGUS CUNICULUS (RABBIT). CPC5_RABIT CYTOCHROME P450 2C5 (EC 1.14.14.1) (CYPIIC5) (P450 1) (PROGESTERONE 21-HYDROXYLASE) (P450IIC5) - ORYCTOLAGUS CUNICULUS (RABBIT). CPC6_RAT CYTOCHROME P450 2C6 (EC 1.14.14.1) (CYPIIC6) (P450 PB1) (PTF2) - RATTUS NORVEGICUS (RAT). CPC8_HUMAN CYTOCHROME P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 FORM 1) (P450 MP- 12/MP-20) (P450 IIC2) (S-MEPHENYTOIN 4-HYDROXYLASE) - HOMO SAPIENS (HUMAN). CPCD_RAT CYTOCHROME P450 2C13, MALE-SPECIFIC (EC 1.14.14.1) (CYPIIC13) (P450- G) (UT-5) - RATTUS NORVEGICUS (RAT). CPCG_RABIT CYTOCHROME P450 2C16 (EC 1.14.14.1) (CYPIIC16) - ORYCTOLAGUS CUNICULUS (RABBIT). CPCN_RAT CYTOCHROME P450 2C23 (EC 1.14.14.1) (CYPIIC23) (ARACHIDONIC ACID EPOXYGENASE) - RATTUS NORVEGICUS (RAT). CPCP_MESAU CYTOCHROME P450 2C26 (EC 1.14.14.1) (CYPIIC26) (P450 HSM2) - MESOCRICETUS AURATUS (GOLDEN HAMSTER). CPCQ_MESAU CYTOCHROME P450 2C27 (EC 1.14.14.1) (CYPIIC27) (P450 HSM3) - MESOCRICETUS AURATUS (GOLDEN HAMSTER). CPD1_RAT Cytochrome P450 2D1 (EC 1.14.14.1) (CYPIID1) (P450-DB1) (P450-CMF1A) (P450-UT-7) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat). CPD3_RAT Cytochrome P450 2D3 (EC 1.14.14.1) (CYPIID3) (P450-DB3) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat). CPD4_RAT Cytochrome P450 2D4 (EC 1.14.14.1) (CYPIID4) (P450-DB4) (P450-CMF3) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat). CPD5_RAT Cytochrome P450 2D5 (EC 1.14.14.1) (CYPIID5) (P450-DB5) (P450-CMF1B) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat). CPD6_HUMAN Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (P450-DB1) (Debrisoquine 4-hydroxylase) - Homo sapiens (Human). CPD9_MOUSE Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9) (P450-16-alpha) (CA) (Testosterone 16-alpha hydroxylase) - Mus musculus (Mouse). CPDA_MOUSE Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (P450-16-alpha) (P450CB) (Testosterone 16-alpha hydroxylase) - Mus musculus (Mouse). CPDF_CANFA Cytochrome P450 2D15 (EC 1.14.14.1) (CYPIID15) (P450 DUT2) - Canis familiaris (Dog). CPDG_CAVPO Cytochrome P450 2D16 (EC 1.14.14.1) (CYPIID16) - Cavia porcellus (Guinea pig). CPDH_MACFA Cytochrome P450 2D17 (EC 1.14.14.1) (CYPIID17) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). CPDI_RAT Cytochrome P450 2D18 (EC 1.14.14.1) (CYPIID18) (P450 2D-29/2D-35) - Rattus norvegicus (Rat). CPDJ_CALJA Cytochrome P450 2D19 (EC 1.14.14.1) (CYPIID19) (P450 CM2D-1) - Callithrix jacchus (Common marmoset). CPE1_BOVIN Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) - Bos taurus (Bovine). CPE1_HUMAN Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) - Homo sapiens (Human). CPE1_MESAU Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) - Mesocricetus auratus (Golden hamster). CPE1_MOUSE Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) (P450-ALC) - Mus musculus (Mouse). CPE1_PIG Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) (P-450-J) - Sus scrofa (Pig). CPE1_RABIT Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (Isozyme 3A) (P450-ALC) - Oryctolagus cuniculus (Rabbit). CPE1_RAT Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) (P450RLM6) - Rattus norvegicus (Rat). CPJ1_RABIT Cytochrome P450 2J1 (EC 1.14.14.1) (CYPIIJ1) (P-450IB) - Oryctolagus cuniculus (Rabbit). CPJ2_HUMAN Cytochrome P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (Arachidonic acid epoxygenase) - Homo sapiens (Human). CPK1_ONCMY CYTOCHROME P450 2K1 (EC 1.14.14.1) (CYPIIK1) (P450 LMC2) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI). CPM1_BOVIN CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6) (CYPXIA1) (P450(SCC)) (CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME) (CHOLESTEROL DESMOLASE) - BOS TAURUS (BOVINE). CPM1_CAPHI CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6) (CYPXIA1) (P450(SCC)) (CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME) (CHOLESTEROL DESMOLASE) - CAPRA HIRCUS (GOAT). CPM1_ONCMY CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6) (CYPXIA1) (P450(SCC)) (CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME) (CHOLESTEROL DESMOLASE) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI). CPM1_PIG CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6) (CYPXIA1) (P450(SCC)) (CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME) (CHOLESTEROL DESMOLASE) - SUS SCROFA (PIG). CPM1_SHEEP CYTOCHROME P450 11A1, MITOCHONDRIAL PRECURSOR (EC 1.14.15.6) (CYPXIA1) (P450(SCC)) (CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME) (CHOLESTEROL DESMOLASE) - OVIS ARIES (SHEEP). CPN1_CAVPO CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P450C11) (STEROID 11-BETA-HYDROXYLASE) (ALDOSTERONE SYNTHASE) - CAVIA PORCELLUS (GUINEA PIG). CPN1_MESAU CYTOCHROME P450 11B1 PRECURSOR (EC 1.14.15.4) (CYPXIB1) (P450C11) (STEROID 11-BETA-HYDROXYLASE) - MESOCRICETUS AURATUS (GOLDEN HAMSTER). CPP1_DROAC CYTOCHROME P450 12B1 PRECURSOR (EC 1.14.-.-) (CYPXIIB1) - DROSOPHILA ACANTHOPTERA (FRUIT FLY). CPS1_BOVIN CYTOCHROME P450 XXIA1 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) (P450-C21) - BOS TAURUS (BOVINE). CPS1_HUMAN CYTOCHROME P450 XXIB (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) (P450-C21B) - HOMO SAPIENS (HUMAN). CPS1_PIG CYTOCHROME P450 XXIA1 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) (P450-C21) - SUS SCROFA (PIG). CPS3_PIG CYTOCHROME P450 XXIA3 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) (P450-C21) - SUS SCROFA (PIG). CPT7_ICTPU CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - ICTALURUS PUNCTATUS (CHANNEL CATFISH). CPT7_RANDY CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE) - RANA DYBOWSKII (FROG). CPXN_ANASP PROBABLE CYTOCHROME P450 110 (EC 1.14.-.-) (ORF3) - ANABAENA SP. (STRAIN PCC 7120). CPXU_BRAJA CYTOCHROME P450 BJ-4 (EC 1.14.14.-) (CYTOCHROME P450 117) - BRADYRHIZOBIUM JAPONICUM. CPZ6_CANFA CYTOCHROME P450 2C41 (EC 1.14.14.1) (CYPIIC41) - CANIS FAMILIARIS (DOG). ERG5_YEAST CYTOCHROME P450 61 (EC 1.14.14.-) (C-22 STEROL DESATURASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). HNF4_DROME TRANSCRIPTION FACTOR HNF-4 HOMOLOG (DHNF4) - DROSOPHILA MELANOGASTER (FRUIT FLY). O02641 PUTATIVE CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS ELEGANS. O16362 F44C8.1 PROTEIN - CAENORHABDITIS ELEGANS. O16671 F41B5.3 PROTEIN - CAENORHABDITIS ELEGANS. O16673 F41B5.2 PROTEIN - CAENORHABDITIS ELEGANS. O22185 PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O22188 PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O22744 PUTATIVE OBTUSIFOLIOL 14-ALPHA DEMETHYLASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O23154 CYTOCHROME P450-LIKE PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O23387 SIMILARITY TO CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O23389 SIMILARITY TO CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O23397 ALLENE OXIDE SYNTHASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O26651 DNA HELICASE II RELATED PROTEIN - METHANOBACTERIUM THERMOAUTOTROPHICUM. O33959 TYL ORFX - STREPTOMYCES FRADIAE. O44652 K07C6.2 PROTEIN - CAENORHABDITIS ELEGANS. O44656 B0213.11 PROTEIN - CAENORHABDITIS ELEGANS. O44657 B0213.12 PROTEIN - CAENORHABDITIS ELEGANS. O44659 B0213.15 PROTEIN - CAENORHABDITIS ELEGANS. O44704 C45H4.2 PROTEIN - CAENORHABDITIS ELEGANS. O45605 H02I12.8 PROTEIN - CAENORHABDITIS ELEGANS. O46051 EG:152A3.2 PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY). O46053 COSMID 152A3 - DROSOPHILA MELANOGASTER (FRUIT FLY). O48786 PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O52819 PCZA363.3 - AMYCOLATOPSIS ORIENTALIS. O58111 230AA LONG HYPOTHETICAL COBALAMIN SYNTHASE - PYROCOCCUS HORIKOSHII. O61204 B0213.16 PROTEIN - CAENORHABDITIS ELEGANS. O61935 COSMID T09H2 - CAENORHABDITIS ELEGANS. O62377 T10H4.11 PROTEIN - CAENORHABDITIS ELEGANS. O62378 T10H4.10 PROTEIN - CAENORHABDITIS ELEGANS. O64853 PUTATIVE THROMBOXANE-A SYNTHASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O64989 STEROID 22-ALPHA-HYDROXYLASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O76345 CYTOCHROME P450 - HOMARUS AMERICANUS (AMERICAN LOBSTER). O76800 CYP6-LIKE MICROSOMAL CYTOCHROME P450 - DROSOPHILA MELANOGASTER (FRUIT FLY). O88037 HYPOTHETICAL 100.1 KD PROTEIN - STREPTOMYCES COELICOLOR. O93297 CYTOCHROME P450 2K4 (EC 1.14.14.1) (CYPIIK4) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI). O93304 CYTOCHROME P450 2K1 (EC 1.14.14.1) (CYPIIK1) (P450 LMC2) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI). P70983 ALKALINE AMYLOPULLULANASE - BACILLUS SP. P77900 HYPOTHETICAL 52.2 KD PROTEIN CY21B4.11C (EC 1.14.14.1) - MYCOBACTERIUM TUBERCULOSIS. P95746 HYPOTHETICAL 44.1 KD PROTEIN - STREPTOMYCES FRADIAE. P96813 HYPOTHETICAL 49.3 KD PROTEIN (EC 1.14.14.1) - MYCOBACTERIUM TUBERCULOSIS. Q06884 CYTOCHROME P450 IIIA (EC 1.14.14.1) (STEROID INDUCIBLE) - Rattus norvegicus (Rat). Q08078 CYTOCHROME P450 2C25 (EC 1.14.14.1) (CYPIIC25) (P450 HSM1) - MESOCRICETUS AURATUS (GOLDEN HAMSTER). Q16741 CYTOCHROME P450 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE). (EC 1.14.14.1) - HOMO SAPIENS (HUMAN). Q16742 CYTOCHROME P450 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) - HOMO SAPIENS (HUMAN). Q16749 CYTOCHROME P450 (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) - HOMO SAPIENS (HUMAN). Q16753 DEBRISOQUINE 4-HYDROXYLASE MUTANT ALLELE (EC 1.14.14.1) - Homo sapiens (Human). Q16874 CYTOCHROME P450 21-HYDROXYLASE (STEROID 21-MONOOXYGENASE) (EC 1.14.99.10) (STEROID 21-HYDROXYLASE) (CYTOCHROME P450 XXIA1) - HOMO SAPIENS (HUMAN). Q27471 SIMILAR TO CYTOCHROME P450 (EC 1.14.14.1) - CAENORHABDITIS ELEGANS. Q27506 K09A11.2 PROTEIN - CAENORHABDITIS ELEGANS. Q29454 CYTOCHROME P450 IID (EC 1.14.14.1) - Bos taurus (Bovine). Q29508 CYTOCHROME P450 (P450IIE2) (EC 1.14.14.1) - Oryctolagus cuniculus (Rabbit). Q42959 CYTOCHROME P450 (EC 1.14.14.1) - NICOTIANA TABACUM (COMMON TOBACCO). Q43071 CYTOCHROME P450 (EC 1.14.14.1) - PHALAENOPSIS SP. Q54296 POLYKETIDE SYNTHASE - STREPTOMYCES HYGROSCOPICUS. Q59163 CYTOCHROME P450 (EC 1.14.14.1) - ANABAENA VARIABILIS. Q64460 CYTOCHROME P450 (TESTOSTERONE 16-ALPHA HYDROXYLASE TYPE B) (EC 1.14.14.1) - Mus musculus (Mouse). Q64463 CYTOCHROME P450 (TESTOSTERONE 16-ALPHA HYDROXYLASE TYPE A) (EC 1.14.14.1) - Mus musculus (Mouse). Q64529 CYTOCHROME P450 16A-MS1 (EC 1.14.14.1) - Mus spretus (Western wild mouse). Q64530 CYTOCHROME P450 16A-MS2 (EC 1.14.14.1) - Mus spretus (Western wild mouse). Q64590 CYTOCHROME P450 (EC 1.14.14.1) - RATTUS NORVEGICUS (RAT). Q64615 CYTOCHROME P450 C27/25 (EC 1.14.14.1) - RATTUS NORVEGICUS (RAT). Q64639 CYTOCHROME P450 C27/25 (EC 1.14.14.1) - RATTUS NORVEGICUS (RAT). Q92088 CYTOCHROME P450 2M1 (EC 1.14.14.1) (CYPIIM1) (AURIC ACID OMEGA-6- HYDROXYLASE) (LMC1) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI). Q92129 CYTOCHROME P-450 (EC 1.14.14.1) - Xenopus laevis (African clawed frog). STCF_EMENI PROBABLE STERIGMATOCYSTIN BIOSYNTHESIS P450 MONOOXYGENASE STCF (EC 1.14.-.-) (CYTOCHROME P450 60A2) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS). STCL_EMENI PROBABLE STERIGMATOCYSTIN BIOSYNTHESIS P450 MONOOXYGENASE STCL (EC 1.14.-.-) (CYTOCHROME P450 60B) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS). THAS_HUMAN THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) - HOMO SAPIENS (HUMAN). THAS_MOUSE THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) (TS) - MUS MUSCULUS (MOUSE). TR11_FUSSP ISOTRICHODERMIN C-15 HYDROXYLASE (EC 1.14.-.-) (CYTOCHROME P450 65A1) - FUSARIUM SPOROTRICHIOIDES. YDAK_CAEEL PUTATIVE CYTOCHROME P450 C34B7.3 IN CHROMOSOME I (EC 1.14.-.-) - CAENORHABDITIS ELEGANS.
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