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PR00345

Identifier
STATHMIN  [View Relations]  [View Alignment]  
Accession
PR00345
No. of Motifs
5
Creation Date
04-OCT-1994  (UPDATE 07-JUN-1999)
Title
Stathmin family signature
Database References

PROSITE; PS00563 STATHMIN
BLOCKS; BL00563
PFAM; PF00836 Stathmin
INTERPRO; IPR000956
Literature References
1. MAUCUER, A., DOYE, V. AND SOBEL, A.
A single amino acid difference distinguishes the human and the rat
sequences of stathmin, a ubiquitous intracellular phosphoprotein 
associated with cell regulation.
FEBS LETT. 264 275-278 (1990).
 
2. MAUCUER, A., MOREAU, J., MECHALI, M. AND SOBEL, A.
Stathmin gene family: phylogenetic conservation and developmental
regulation in Xenopus.
J.BIOL.CHEM. 268 16420-16429 (1993).
 
3. DOYE, V., SOUBRIER, F., BAUW, G., BOUTTERIN, M.C., BERETTA, L., 
KOPPEL, J., VANDEKERCKHOVE, J. AND SOBEL, A.
A single cDNA encodes two isoforms of stathmin, a developmentally
regulated neuron-enriched phosphoprotein.
J.BIOL.CHEM. 264 12134-12137 (1989).

Documentation
Stathmin is a ubiquitous phosphorylated protein thought to act as an
intracellular relay for diverse regulatory pathways [1], functioning
through a variety of second messengers. Its phosphorylation and gene
expression are regulated throughout development [2] and in response to
extracellular signals regulating cell proliferation, differentiation and
function [3]. Stathmin, and the related proteins SCG10 and XB3, contains a
N-terminal domain (XB3 contains an additional N-terminal hydrophobic
region), a 78 amino acid coiled-coil region, and a short C-terminal domain.
 
STATHMIN is a 5-element fingerprint that provides a signature for
stathmins. The fingerprint was derived from an initial alignment of 4
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motif 2 including the region encoded by PROSITE
pattern STATHMIN (PS00563), which corresponds to a well-conserved deca-
peptide containing the first 3 coiled coil residues. Two iterations on
OWL24.0 were required to reach convergence, at which point a true set
comprising 9 sequences was identified.
 
An update on SPTR37_9f identified a true set of 17 sequences.
Summary Information
17 codes involving  5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
51717171717
400000
300000
200000
12345
True Positives
O14952        O70166        O75527        O93388        
SCG1_CHICK SCG1_HUMAN SCG1_MOUSE SCG1_RAT
SCGA_XENLA SCGB_XENLA STB3_RAT STB3_XENLA
STH1_XENLA STHM_CHICK STHM_HUMAN STHM_MOUSE
STHM_RAT
Sequence Titles
O14952      SILENCER ELEMENT - HOMO SAPIENS (HUMAN).      
O70166 SCG10-RELATED PROTEIN HIAT3 - MUS MUSCULUS (MOUSE).
O75527 SCG10-LIKE-PROTEIN - HOMO SAPIENS (HUMAN).
O93388 NEUROPLASTICIN-2 - GALLUS GALLUS (CHICKEN).
SCG1_CHICK SCG10 PROTEIN (SUPERIOR CERVICAL GANGLION-10 PROTEIN) - GALLUS GALLUS (CHICKEN).
SCG1_HUMAN SCG10 PROTEIN (SUPERIOR CERVICAL GANGLION-10 PROTEIN) - HOMO SAPIENS (HUMAN).
SCG1_MOUSE SCG10 PROTEIN (SUPERIOR CERVICAL GANGLION-10 PROTEIN) - MUS MUSCULUS (MOUSE).
SCG1_RAT SCG10 PROTEIN (SUPERIOR CERVICAL GANGLION-10 PROTEIN) - RATTUS NORVEGICUS (RAT).
SCGA_XENLA SCG10 PROTEIN HOMOLOG A (CLONE SC15) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
SCGB_XENLA SCG10 PROTEIN HOMOLOG A (CLONE SC14) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
STB3_RAT STATHMIN-LIKE PROTEIN B3 (RB3) - RATTUS NORVEGICUS (RAT).
STB3_XENLA STATHMIN-LIKE PROTEIN B3 (XB3) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
STH1_XENLA STATHMIN (CLONE XO35) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
STHM_CHICK STATHMIN - GALLUS GALLUS (CHICKEN).
STHM_HUMAN STATHMIN (PHOSPHOPROTEIN P19) (PP19) (ONCOPROTEIN 18) (OP18) (LEUKEMIA-ASSOCIATED PHOSPHOPROTEIN P18) (PP17) (PROSOLIN) (METABLASTIN) (PR22 PROTEIN) - HOMO SAPIENS (HUMAN).
STHM_MOUSE STATHMIN (PHOSPHOPROTEIN P19) (PP19) (ONCOPROTEIN 18) (OP18) (LEUKEMIA-ASSOCIATED PHOSPHOPROTEIN P18) (PP17) (PROSOLIN) (METABLASTIN) (PR22 PROTEIN) - MUS MUSCULUS (MOUSE).
STHM_RAT STATHMIN (PHOSPHOPROTEIN P19) (PP19) (ONCOPROTEIN 18) (OP18) (LEUKEMIA-ASSOCIATED PHOSPHOPROTEIN P18) (PP17) (PROSOLIN) (METABLASTIN) (PR22 PROTEIN) - RATTUS NORVEGICUS (RAT).
Scan History
OWL24_0    2  100  NSINGLE    
OWL28_0 1 100 NSINGLE
SPTR37_9f 2 19 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
VKELEKRASGQAFELILSP STHM_HUMAN 7 7 -
VKELEKRASGQAFELILGP STHM_CHICK 8 8 -
VKQLNKRASGQAFELILKP XLSCG10B 42 42 -
VKQINKRASGQAFELILKP CHKSCG 42 42 -
IKQLNKRASGQAFELILKP XLSCG10A 42 42 -
VIELNKRASGHSFEVILKP XLXB3A 52 52 -
VKQINKRASGQAFELILLP SCG1_RAT 42 42 -
VKQLEKRASGQAFELILSP XLXO35A 8 8 -
VKELEKRASGQAFELILSP STHM_RAT 7 7 -

Motif 2 width=29
Element Seqn Id St Int Rpt
LASPKKKDVSLGEIQAKLEAAEDRRKSQE XLSCG10A 71 10 -
ATLPQKRDPSLEEIQKKLEAAEERRKYRE XLXB3A 81 10 -
LASPKKKDLSLEEIQKKLEAAEGRRKSQE SCG1_RAT 71 10 -
LSPPKKKDLSLEEIQKKLEAAEERRKSHE STHM_RAT 36 10 -
LSPPKKKDLSLEEIQKKLEAAEERRKSHE STHM_HUMAN 36 10 -
LSPPKKKDLSLEEIQKKLEAAEERRKSHE STHM_CHICK 37 10 -
ITSPKKKECSLEEIQKKLEAAEERRKLHE XLXO35A 37 10 -
LASPKRKDVSLEEIQAKLEAAEERRKSQE XLSCG10B 71 10 -
LASPKKKELSLEEIQKKLEAAEERRKSQE CHKSCG 71 10 -

Motif 3 width=24
Element Seqn Id St Int Rpt
AEVLKQLAEKREHEKEVLQKAIEE STHM_CHICK 66 0 -
AEVLKQLAEKREHEKEVLQKAIEE STHM_HUMAN 65 0 -
AEILKQLAEKREHEKEVLQKAIEE XLXO35A 66 0 -
AQILKQLAEKREHEREVLQKALEE XLSCG10B 100 0 -
AQVLKHLAEKREHEREVLQKALEE CHKSCG 100 0 -
AQILKQLAEKREHEREVLQKALEE XLSCG10A 100 0 -
AELRKHQAEKREHEREVILKAIEE XLXB3A 110 0 -
AEVLKQLAEKREHEKEVLQKAIEE STHM_RAT 65 0 -
AQVLKQLAEKREHEREVLQKALEE SCG1_RAT 100 0 -

Motif 4 width=24
Element Seqn Id St Int Rpt
NNNFSKMAEEKLTHKMEANKENRE STHM_HUMAN 89 0 -
NNNFSKMAEEKLTTKMETIKENRE XLXO35A 90 0 -
NNNFSRMAEEKLVLKMEQIKENRE XLSCG10B 124 0 -
NNNFSKMAEEKLILKMEQIKENRE CHKSCG 124 0 -
NNNFSRMAEEKLILKMEQIKENRE XLSCG10A 124 0 -
NNNFSKMAKEKLAQRMEVNKENRE XLXB3A 134 0 -
NNNFSKMAEEKLILKMEQIKENRE SCG1_RAT 124 0 -
NNNFSKMAEEKLTHKMEANKENRE STHM_RAT 89 0 -
NNNFSKMAEEKLTHKMEANKENRE STHM_CHICK 90 0 -

Motif 5 width=25
Element Seqn Id St Int Rpt
YYLASLMERLKEKERHAADVRKNKE XLSCG10B 148 0 -
AQMAAKLERLREKDKHVEEVRKNKE STHM_RAT 113 0 -
AQMAAKLERLREKDKHIEEVRKNKE STHM_HUMAN 113 0 -
AQIAAKLERLREKDKKVEEIRKGKE XLXO35A 114 0 -
AQMAAKLERLREKDKHIEEVRKNKE STHM_CHICK 114 0 -
ANLAAIIERLQEKERHAAEVRRNKE SCG1_RAT 148 0 -
AHLAAMLERLQEKDKHAEEVRKNKE XLXB3A 158 0 -
YYLASLMERLKEKERHAAEVRRNKE XLSCG10A 148 0 -
ANLAALIERLQEKERHAAEVRRNKE CHKSCG 148 0 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
VKQINKRASGQAFELILLP SCG1_RAT 42 42 -
VKQINKRASGQAFELILKP SCG1_MOUSE 42 42 -
VKQINKRASGQAFELILKP SCG1_HUMAN 42 42 -
VKQINKRASGQAFELILKP O14952 42 42 -
VKQINKRASGQAFELILKP SCG1_CHICK 42 42 -
VKELEKRASGQAFELILSP STHM_MOUSE 7 7 -
VKELEKRASGQAFELILSP STHM_RAT 7 7 -
VKELEKRASGQAFELILSP STHM_HUMAN 7 7 -
VKELEKRASGQAFELILGP STHM_CHICK 8 8 -
VKQLNKRASGQAFELILKP SCGB_XENLA 42 42 -
IKQLNKRASGQAFELILKP SCGA_XENLA 42 42 -
VKQLDKRASGQSFEVILKS O75527 42 42 -
VKQLDKRASGQSFEVILKS O93388 42 42 -
VKQLDKRASGQSFEVILKS O70166 42 42 -
VKQLEKRASGQAFELILSP STH1_XENLA 8 8 -
VIELNKCTSGQSFEVILKP STB3_RAT 52 52 -
VIELNKRASGHSFEVILKP STB3_XENLA 52 52 -

Motif 2 width=29
Element Seqn Id St Int Rpt
LASPKKKDLSLEEIQKKLEAAEERRKSQE SCG1_MOUSE 71 10 -
LASPKKKDLSLEEIQKKLEAAGERRKSQE SCG1_HUMAN 71 10 -
LASPKKKDLSLEEIQKKLEAAEERRKSQE O14952 71 10 -
LASPKKKELSLEEIQKKLEAAEERRKSQE SCG1_CHICK 71 10 -
LASPKKKDLSLEEIQKKLEAAEGRRKSQE SCG1_RAT 71 10 -
LSPPKKKDLSLEEIQKKLEAAEERRKSHE STHM_MOUSE 36 10 -
LSPPKKKDLSLEEIQKKLEAAEERRKSHE STHM_RAT 36 10 -
LSPPKKKDLSLEEIQKKLEAAEERRKSHE STHM_HUMAN 36 10 -
LSPPKKKDLSLEEIQKKLEAAEERRKSHE STHM_CHICK 37 10 -
LASPKRKDVSLEEIQAKLEAAEERRKSQE SCGB_XENLA 71 10 -
LASPKKKDVSLGEIQAKLEAAEDRRKSQE SCGA_XENLA 71 10 -
PSPPKKKDTSLEELQKRLEAAEERRKTQE O75527 72 11 -
SSPPKKKDLSLEELQRRLEAAEERRKTQE O93388 72 11 -
SSPPKRKDASLEELQKRLEAAEERRKTQE O70166 72 11 -
ITSPKKKECSLEEIQKKLEAAEERRKLHE STH1_XENLA 37 10 -
ASLPRRRDPSLEEIQKKLEAAEERRKYQE STB3_RAT 81 10 -
ATLPQKRDPSLEEIQKKLEAAEERRKYRE STB3_XENLA 81 10 -

Motif 3 width=24
Element Seqn Id St Int Rpt
AQVLKQLAEKREHEREVLQKALEE SCG1_MOUSE 100 0 -
AQVLKQLAEKREHEREVLQKALEE SCG1_HUMAN 100 0 -
AQVLKQLAEKREHEREVLQKALGE O14952 100 0 -
AQVLKHLAEKREHEREVLQKALEE SCG1_CHICK 100 0 -
AQVLKQLAEKREHEREVLQKALEE SCG1_RAT 100 0 -
AEVLKQLAEKREHEKEVLQKAIEE STHM_MOUSE 65 0 -
AEVLKQLAEKREHEKEVLQKAIEE STHM_RAT 65 0 -
AEVLKQLAEKREHEKEVLQKAIEE STHM_HUMAN 65 0 -
AEVLKQLAEKREHEKEVLQKAIEE STHM_CHICK 66 0 -
AQILKQLAEKREHEREVLQKALEE SCGB_XENLA 100 0 -
AQILKQLAEKREHEREVLQKALEE SCGA_XENLA 100 0 -
AQVLKQLAERREHEREVLHKALEE O75527 101 0 -
AQVLKQLAEKREHEREVLHKALEE O93388 101 0 -
AQVLKQLAERREHEREVLHKALEE O70166 101 0 -
AEILKQLAEKREHEKEVLQKAIEE STH1_XENLA 66 0 -
AELLKHLAEKREHEREVIQKAIEE STB3_RAT 110 0 -
AELRKHQAEKREHEREVILKAIEE STB3_XENLA 110 0 -

Motif 4 width=24
Element Seqn Id St Int Rpt
NNNFSKMAEEKLILKMEQIKENRE SCG1_MOUSE 124 0 -
NNNFSKMAEEKLILKMEQIKENRE SCG1_HUMAN 124 0 -
NNNFSKMAEEKLILKMEQIKENRE O14952 124 0 -
NNNFSKMAEEKLILKMEQIKENRE SCG1_CHICK 124 0 -
NNNFSKMAEEKLILKMEQIKENRE SCG1_RAT 124 0 -
NNNFSKMAEEKLTHKMEANKENRE STHM_MOUSE 89 0 -
NNNFSKMAEEKLTHKMEANKENRE STHM_RAT 89 0 -
NNNFSKMAEEKLTHKMEANKENRE STHM_HUMAN 89 0 -
NNNFSKMAEEKLTHKMEANKENRE STHM_CHICK 90 0 -
NNNFSRMAEEKLVLKMEQIKENRE SCGB_XENLA 124 0 -
NNNFSRMAEEKLILKMEQIKENRE SCGA_XENLA 124 0 -
NNNFSRQAEEKLNYKMELSKEIRE O75527 125 0 -
NNNFSRLAEEKLNYKMELSREIRE O93388 125 0 -
NNNFSRLAEEKLNYKMELSKEIRE O70166 125 0 -
NNNFSKMAEEKLTTKMETIKENRE STH1_XENLA 90 0 -
NNNFIKMAKEKLAQKMESNKENRE STB3_RAT 134 0 -
NNNFSKMAKEKLAQRMEVNKENRE STB3_XENLA 134 0 -

Motif 5 width=25
Element Seqn Id St Int Rpt
ANLAAIIERLQEKERHAAEVRRNKE SCG1_MOUSE 148 0 -
ANLAAIIERLQEKERHAAEVRRNKE SCG1_HUMAN 148 0 -
ANLAAIIERLQEKERHAAEVRRNKE O14952 148 0 -
ANLAALIERLQEKERHAAEVRRNKE SCG1_CHICK 148 0 -
ANLAAIIERLQEKERHAAEVRRNKE SCG1_RAT 148 0 -
AQMAAKLERLREKDKHVEEVRKNKE STHM_MOUSE 113 0 -
AQMAAKLERLREKDKHVEEVRKNKE STHM_RAT 113 0 -
AQMAAKLERLREKDKHIEEVRKNKE STHM_HUMAN 113 0 -
AQMAAKLERLREKDKHIEEVRKNKE STHM_CHICK 114 0 -
YYLASLMERLKEKERHAADVRKNKE SCGB_XENLA 148 0 -
YYLASLMERLKEKERHAAEVRRNKE SCGA_XENLA 148 0 -
AHLAALRERLREKELHAAEVRRNKE O75527 149 0 -
AHLAALRERLREKELHAAEVRRNKE O93388 149 0 -
AHLAALRERLREKELHAAEVRRNKE O70166 149 0 -
AQIAAKLERLREKDKKVEEIRKGKE STH1_XENLA 114 0 -
AHLAAMLERLQEKDKHAEEVRKNKE STB3_RAT 158 0 -
AHLAAMLERLQEKDKHAEEVRKNKE STB3_XENLA 158 0 -