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PR00341

Identifier
PRION  [View Relations]  [View Alignment]  
Accession
PR00341
No. of Motifs
8
Creation Date
19-OCT-1992  (UPDATE 07-JUN-1999)
Title
Prion protein signature
Database References

PROSITE; PS00291 PRION_1; PS00706 PRION_2
BLOCKS; BL00291
PFAM; PF00377 prion
INTERPRO; IPR000817
Literature References
1. STAHL, N. AND PRUSINER, S.B.
Prions and prion proteins.
FASEB J. 5 2799-2807 (1991).
 
2. BRUNORI, M., CHIARA SILVESTRINI, M. AND POCCHIARI, M.
The scrapie agent and the prion hypothesis.
TRENDS BIOCHEM.SCI. 13 309-313 (1988).
 
3. PRUSINER, S.B.
Scrapie prions.
ANNU.REV.MICROBIOL. 43 345-374 (1989).

Documentation
Prion protein (PrP) is a small glycoprotein found in high quantity in the 
brain of animals infected with certain degenerative neurological diseases,
such as sheep scrapie and bovine spongiform encephalopathy (BSE), and the
human dementias Creutzfeldt-Jacob disease (CJD) and Gerstmann-Straussler 
syndrome (GSS). PrP is encoded in the host genome and is expressed both in 
normal and infected cells. During infection, however, the PrP molecules 
become altered and polymerise, yielding fibrils of modified PrP protein.
 
PrP molecules have been found on the outer surface of plasma membranes of
nerve cells, to which they are anchored through a covalent-linked
glycolipid, suggesting a role as a membrane receptor. PrP is also expressed
in other tissues, indicating that it may have different functions depending
on its location. 
 
The primary sequences of PrP's from different sources are highly similar: 
all bear an N-terminal domain containing multiple tandem repeats of a 
Pro/Gly rich octapeptide; sites of Asn-linked glycosylation; an essential 
disulphide bond; and 3 hydrophobic segments. These sequences show some 
similarity to a chicken glycoprotein, thought to be an acetylcholine 
receptor-inducing activity (ARIA) molecule. It has been suggested that 
changes in the octapeptide repeat region may indicate a predisposition to 
disease, but it is not known for certain whether the repeat can 
meaningfully be used as a fingerprint to indicate susceptibility.
 
PRION is an 8-element fingerprint that provides a signature for the prion
proteins. The fingerprint was derived from an initial alignment of 5
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, including the 3 hydrophobic domains and the
octapeptide repeats (WGQPHGGG). Two iterations on OWL18.0 were required
to reach convergence, at which point a true set comprising 9 sequences was
identified. Several partial matches were also found: these include a
fragment (PRIO_RAT) lacking part of the sequence bearing the first motif,
and the PrP homologue found in chicken - this matches well with only 2 of
the 3 hydrophobic motifs (1 and 5) and one of the other conserved regions
(6), but has an N-terminal signature based on a sextapeptide repeat
(YPHNPG) rather than the characteristic PrP octapeptide.
 
An update on SPTR37_9f identified a true set of 37 sequences, and 1
partial match.
Summary Information
  37 codes involving  8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
83737373737373737
700000000
600000000
500000000
400000000
310001100
200000000
12345678
True Positives
O46593        O46648        O75942        PRIO_ATEPA    
PRIO_BOVIN PRIO_CALJA PRIO_CAMDR PRIO_CANFA
PRIO_CAPHI PRIO_CEBAP PRIO_CERAE PRIO_CEREL
PRIO_COLGU PRIO_CRIGR PRIO_CRIMI PRIO_FELCA
PRIO_GORGO PRIO_HUMAN PRIO_MACFA PRIO_MESAU
PRIO_MOUSE PRIO_MUSPF PRIO_MUSVI PRIO_ODOHE
PRIO_PANTR PRIO_PIG PRIO_PONPY PRIO_PREFR
PRIO_RABIT PRIO_RAT PRIO_SAISC PRIO_SHEEP
PRIO_TRIVU PRP1_TRAST PRP2_BOVIN PRP2_TRAST
Q15216
True Positive Partials
Codes involving 3 elements
PRIO_CHICK
Sequence Titles
O46593      PRION PROTEIN - CANIS FAMILIARIS (DOG).       
O46648 PRION PROTEIN PRECURSOR - OVIS ARIES (SHEEP), AND OVIBOS MOSCHATUS (MUSKOX).
O75942 PRION PROTEIN PRECURSOR - HOMO SAPIENS (HUMAN).
PRIO_ATEPA MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - ATELES PANISCUS (BLACK SPIDER MONKEY).
PRIO_BOVIN MAJOR PRION PROTEIN 1 PRECURSOR (PRP) (MAJOR SCRAPIE-ASSOCIATED FIBRIL PROTEIN 1) - BOS TAURUS (BOVINE).
PRIO_CALJA MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - CALLITHRIX JACCHUS (COMMON MARMOSET).
PRIO_CAMDR MAJOR PRION PROTEIN PRECURSOR (PRP) - CAMELUS DROMEDARIUS (DROMEDARY) (ARABIAN CAMEL).
PRIO_CANFA MAJOR PRION PROTEIN PRECURSOR (PRP) - CANIS FAMILIARIS (DOG).
PRIO_CAPHI MAJOR PRION PROTEIN PRECURSOR (PRP) - CAPRA HIRCUS (GOAT).
PRIO_CEBAP MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - CEBUS APELLA (BROWN-CAPPED CAPUCHIN).
PRIO_CERAE MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET), AND CERCOPITHECUS DIANAE.
PRIO_CEREL MAJOR PRION PROTEIN PRECURSOR (PRP) - CERVUS ELAPHUS (RED DEER).
PRIO_COLGU MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - COLOBUS GUEREZA.
PRIO_CRIGR MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - CRICETULUS GRISEUS (CHINESE HAMSTER).
PRIO_CRIMI MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - CRICETULUS MIGRATORIUS (ARMENIAN HAMSTER).
PRIO_FELCA MAJOR PRION PROTEIN PRECURSOR (PRP) - FELIS SILVESTRIS CATUS (CAT).
PRIO_GORGO MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - GORILLA GORILLA GORILLA (LOWLAND GORILLA).
PRIO_HUMAN MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) (ASCR) - HOMO SAPIENS (HUMAN).
PRIO_MACFA MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY), MACACA ARCTOIDES (STUMP-TAILED MACAQUE), MACACA FUSCATA FUSCATA (JAPANESE MACAQUE), MACACA MULATTA (RHESUS MACAQUE), MACACA NEMESTRINA (PIG-TAILED MACAQUE), AND PAPIO HAMADRYAS (HAMADRYAS BABOON).
PRIO_MESAU MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
PRIO_MOUSE MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - MUS MUSCULUS (MOUSE).
PRIO_MUSPF MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - MUSTELA PUTORIUS FURO (FERRET).
PRIO_MUSVI MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - MUSTELA VISON (AMERICAN MINK).
PRIO_ODOHE MAJOR PRION PROTEIN PRECURSOR (PRP) - ODOCOILEUS HEMIONUS (MULE DEER) (BLACK-TAILED DEER).
PRIO_PANTR MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - PAN TROGLODYTES (CHIMPANZEE), HYLOBATES LAR (COMMON GIBBON), AND SYMPHALANGUS SYNDACTYLUS (SIAMANG).
PRIO_PIG MAJOR PRION PROTEIN PRECURSOR (PRP) - SUS SCROFA (PIG).
PRIO_PONPY MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - PONGO PYGMAEUS (ORANGUTAN).
PRIO_PREFR MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - PRESBYTIS FRANCOISI.
PRIO_RABIT MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - ORYCTOLAGUS CUNICULUS (RABBIT).
PRIO_RAT MAJOR PRION PROTEIN PRECURSOR (PRP) - RATTUS NORVEGICUS (RAT).
PRIO_SAISC MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - SAIMIRI SCIUREUS (COMMON SQUIRREL MONKEY).
PRIO_SHEEP MAJOR PRION PROTEIN PRECURSOR (PRP) - OVIS ARIES (SHEEP).
PRIO_TRIVU MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) - TRICHOSURUS VULPECULA (BRUSH-TAILED POSSUM).
PRP1_TRAST MAJOR PRION PROTEIN 1 PRECURSOR (PRP) (MAJOR SCRAPIE-ASSOCIATED FIBRIL PROTEIN 1) - TRAGELAPHUS STREPSICEROS (GREATER KUDU).
PRP2_BOVIN MAJOR PRION PROTEIN 2 PRECURSOR (PRP) (MAJOR SCRAPIE-ASSOCIATED FIBRIL PROTEIN 2) - BOS TAURUS (BOVINE).
PRP2_TRAST MAJOR PRION PROTEIN 2 PRECURSOR (PRP) (MAJOR SCRAPIE-ASSOCIATED FIBRIL PROTEIN 2) - TRAGELAPHUS STREPSICEROS (GREATER KUDU).
Q15216 PRION PROTEIN - HOMO SAPIENS (HUMAN).

PRIO_CHICK MAJOR PRION PROTEIN HOMOLOG PRECURSOR (PR-LP) (ACETYLCHOLINE RECEPTOR-INDUCING ACTIVITY) (ARIA) (65-21 PROTEIN) - GALLUS GALLUS (CHICKEN).
Scan History
OWL18_0    2  30   NSINGLE    
OWL19_1 1 30 NSINGLE
OWL26_0 1 160 NSINGLE
OWL29_1 1 150 NSINGLE
SPTR37_9f 2 134 NSINGLE
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
WILVLFVAMWSDVGLC PRIO_SHEEP 9 9 -
WMLVLFVATWSDLGLC PRIO_HUMAN 7 7 -
WLLALFVAMWTDVGLC PRIO_MESAU 7 7 -
WLLALFVTMWTDVGLC PRIO_MOUSE 7 7 -
WILVLFVAMWSDVGLC PRIP_BOVIN 9 9 -
WILVLFVAMWSDVGLC PRIO_BOVIN 9 9 -

Motif 2 width=22
Element Seqn Id St Int Rpt
WNTGGSRYPGQGSPGGNRYPPQ PRIO_MOUSE 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIP_BOVIN 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_HUMAN 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_SHEEP 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_BOVIN 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_MESAU 31 8 -

Motif 3 width=16
Element Seqn Id St Int Rpt
WGQPHGGGWGQPHGGG PRIO_SHEEP 60 4 -
WGQPHGGGWGQPHGGG PRIO_HUMAN 57 4 -
WGQPHGGGWGQPHGGG PRIO_BOVIN 60 4 -
WGQPHGGGWGQPHGGG PRIO_MESAU 57 4 -
WGQPHGGGWGQPHGGS PRIO_MOUSE 56 3 -
WGQPHGGGWGQPHGGG PRIP_BOVIN 60 4 -

Motif 4 width=16
Element Seqn Id St Int Rpt
WGQPHGGGWGQPHGGG PRIO_SHEEP 76 0 -
WGQPHGGGWGQPHGGG PRIP_BOVIN 76 0 -
WGQPHGGGWGQPHGGG PRIO_HUMAN 73 0 -
WGQPHGGGWGQPHGGG PRIO_BOVIN 76 0 -
WGQPHGGGWGQPHGGG PRIO_MESAU 73 0 -
WGQPHGGSWGQPHGGG PRIO_MOUSE 72 0 -

Motif 5 width=20
Element Seqn Id St Int Rpt
VAGAAAAGAVVGGLGGYMLG PRIO_BOVIN 123 31 -
VAGAAAAGAVVGGLGGYMLG PRIP_BOVIN 115 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_MOUSE 111 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_MESAU 112 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_HUMAN 112 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_SHEEP 115 23 -

Motif 6 width=20
Element Seqn Id St Int Rpt
DWEDRYYRENMNRYPNQVYY PRIO_MESAU 144 12 -
DYEDRYYRENMHRYPNQVYY PRIO_HUMAN 144 12 -
DYEDRYYRENMYRYPNQVYY PRIO_SHEEP 147 12 -
DYEDRYYRENMHRYPNQVYY PRIO_BOVIN 155 12 -
DWEDRYYRENMYRYPNQVYY PRIO_MOUSE 143 12 -
DYEDRYYRENMHRYPNQVYY PRIP_BOVIN 147 12 -

Motif 7 width=22
Element Seqn Id St Int Rpt
KGENFTETDIKMMERVVEQMCI PRIP_BOVIN 197 30 -
KGENFTETDVKMMERVVEQMCI PRIO_HUMAN 194 30 -
KGENFTETDIKIMERVVEQMCI PRIO_SHEEP 197 30 -
KGENFTETDIKMMERVVEQMCI PRIO_BOVIN 205 30 -
KGENFTETDIKIMERVVEQMCT PRIO_MESAU 194 30 -
KGENFTETDVKMMERVVEQMCV PRIO_MOUSE 193 30 -

Motif 8 width=19
Element Seqn Id St Int Rpt
ILFSSPPVILLISFLIFLI PRIO_BOVIN 244 17 -
ILFSSPPVILLISFLIFLI PRIO_SHEEP 236 17 -
VLFSSPPVILLISFLIFLI PRIO_MOUSE 234 19 -
VLFSSPPVILLISFLIFLM PRIO_MESAU 234 18 -
VLFSSPPVILLISFLIFLI PRIO_HUMAN 233 17 -
ILFSSPPVILLISFLIFLI PRIP_BOVIN 236 17 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
WMLVLFVATWSDLGLC PRIO_COLGU 7 7 -
WMLVLFVATWSDLGLC PRIO_MACFA 7 7 -
WILVLFVAMWSDVGLC PRIO_CEREL 9 9 -
WILVLFVAMWSDVGLC PRIO_ODOHE 9 9 -
WMLVLFVATWSDLGLC PRIO_GORGO 7 7 -
WMLVLFVATWSDLGLC PRIO_PANTR 7 7 -
WMLVLFVATWSDLGLC PRIO_HUMAN 7 7 -
WILVLFVAMWSDVGLC O46648 9 9 -
WILVLFVAMWSDVGLC PRIO_SHEEP 9 9 -
WMLFLFVATWSDLGLC PRIO_CALJA 7 7 -
WILVLFVAMWSDVGLC PRIO_BOVIN 9 9 -
WILVLFVAMWSDVGLC PRP2_BOVIN 9 9 -
WMLVLFVATWSDLGLC PRIO_ATEPA 7 7 -
WMLVLFVATWSDLGLC PRIO_SAISC 7 7 -
WMLVLFVATWSDLGLC PRIO_PREFR 7 7 -
WMLVLFVATWSNLGLC PRIO_PONPY 7 7 -
WMLVLFVATWSDLGLC O75942 7 7 -
WILVLFVAMWSDVGLC PRIO_CAPHI 9 9 -
WMLVLFVATWSDLGLC PRIO_CEBAP 7 7 -
WILVLFVVTWSDVGLC PRIO_CAMDR 9 9 -
WILVLFVAMWSDVGLC PRIO_FELCA 9 9 -
WILVLFVAMWSDVALC PRP1_TRAST 9 9 -
WMLLLFVATWSDVGLC PRIO_RABIT 7 7 -
WILVLFVAMWSDVALC PRP2_TRAST 9 9 -
WILVLFVAAWSDIGLC PRIO_PIG 9 9 -
WILVLFVAMWSDVGLC PRIO_CANFA 9 9 -
WLLALFVATWTDVGLC PRIO_CRIGR 7 7 -
WLLALFVATWTDVGLC PRIO_CRIMI 7 7 -
WMLVLFVATWSDLGLC Q15216 7 7 -
WLLALFVTTCTDVGLC PRIO_RAT 7 7 -
WMLVVFVATWSDLGLC PRIO_CERAE 7 7 -
WLLVLFVATWSDIGFC PRIO_MUSPF 9 9 -
WLLVLFVATWSDIGFC PRIO_MUSVI 9 9 -
WLLALFVAMWTDVGLC PRIO_MESAU 7 7 -
WLLALFVTMWTDVGLC PRIO_MOUSE 7 7 -
WILLLFVATWSDVGLC O46593 9 9 -
WILVLFIVTWSDLGLC PRIO_TRIVU 9 9 -

Motif 2 width=22
Element Seqn Id St Int Rpt
WNTGGSRYPGQGSPGGNRYPPQ PRIO_COLGU 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_MACFA 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_CEREL 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_ODOHE 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_GORGO 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_PANTR 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_HUMAN 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ O46648 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_SHEEP 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_CALJA 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_BOVIN 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRP2_BOVIN 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_ATEPA 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_SAISC 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_PREFR 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_PONPY 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ O75942 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_CAPHI 34 9 -
WNTGGSRYPGQGSPGGNLYPPQ PRIO_CEBAP 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_CAMDR 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_FELCA 34 9 -
WNTGGSRYPGQGSPGGNRYPSQ PRP1_TRAST 34 9 -
WNTGGSRYPGQSSPGGNRYPPQ PRIO_RABIT 32 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRP2_TRAST 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_PIG 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_CANFA 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_CRIGR 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_CRIMI 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ Q15216 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_RAT 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_CERAE 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_MUSPF 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_MUSVI 34 9 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_MESAU 31 8 -
WNTGGSRYPGQGSPGGNRYPPQ PRIO_MOUSE 31 8 -
NTGGGSRYPGQGSPGGNRYPPQ O46593 34 9 -
SGGSNRYPGQPGSPGGNRYPGW PRIO_TRIVU 37 12 -

Motif 3 width=16
Element Seqn Id St Int Rpt
WGQPHGGGWGQPHGGG PRIO_COLGU 57 4 -
WGQPHGGGWGQPHGGG PRIO_MACFA 57 4 -
WGQPHGGGWGQPHGGG PRIO_CEREL 60 4 -
WGQPHGGGWGQPHGGG PRIO_ODOHE 60 4 -
WGQPHGGGWGQPHGGG PRIO_GORGO 57 4 -
WGQPHGGGWGQPHGGG PRIO_PANTR 57 4 -
WGQPHGGGWGQPHGGG PRIO_HUMAN 57 4 -
WGQPHGGGWGQPHGGG O46648 60 4 -
WGQPHGGGWGQPHGGG PRIO_SHEEP 60 4 -
WGQPHGGGWGQPHGGG PRIO_CALJA 56 3 -
WGQPHGGGWGQPHGGG PRIO_BOVIN 60 4 -
WGQPHGGGWGQPHGGG PRP2_BOVIN 60 4 -
WGQPHGGGWGQPHGGG PRIO_ATEPA 56 3 -
WGQPHGGGWGQPHGGG PRIO_SAISC 56 3 -
WGQPHGGGWGQPHGGG PRIO_PREFR 57 4 -
WGQPHGGGWGQPHGGG PRIO_PONPY 57 4 -
WGQPHGGGWGQPHGGG O75942 57 4 -
WGQPHGGGWGQPHGGG PRIO_CAPHI 60 4 -
WGQPHGGGWGQPHGGG PRIO_CEBAP 56 3 -
WGQPHGGGWGQPHGGG PRIO_CAMDR 60 4 -
WGQPHGGGWGQPHGGG PRIO_FELCA 60 4 -
WGQPHGGGWGQPHGGG PRP1_TRAST 60 4 -
WGQPHGGGWGQPHGGG PRIO_RABIT 57 3 -
WGQPHGGGWGQPHVGG PRP2_TRAST 60 4 -
WGQPHGGGWGQPHGGG PRIO_PIG 60 4 -
WGQPHGGGWGQPHGGG PRIO_CANFA 60 4 -
WGQPHGGGWGQPHGGG PRIO_CRIGR 57 4 -
WGQPHGGGWGQPHGGG PRIO_CRIMI 57 4 -
WGQPHGGGWGQPHGGG Q15216 57 4 -
WGQPHGGGWGQPHGGG PRIO_RAT 57 4 -
WGQPHGGGWGQPHGGG PRIO_CERAE 57 4 -
WGQPHGGGWGQPHGGG PRIO_MUSPF 60 4 -
WGQPHGGGWGQPHGGG PRIO_MUSVI 60 4 -
WGQPHGGGWGQPHGGG PRIO_MESAU 57 4 -
WGQPHGGGWGQPHGGS PRIO_MOUSE 56 3 -
WGQPHGGGWGQPHGGG O46593 60 4 -
HPQGGGTNWGQPHPGG PRIO_TRIVU 60 1 -

Motif 4 width=16
Element Seqn Id St Int Rpt
WGQPHGGGWGQPHGGG PRIO_COLGU 73 0 -
WGQPHGGGWGQPHGGG PRIO_MACFA 73 0 -
WGQPHGGGWGQPHGGG PRIO_CEREL 76 0 -
WGQPHGGGWGQPHGGG PRIO_ODOHE 76 0 -
WGQPHGGGWGQPHGGG PRIO_GORGO 73 0 -
WGQPHGGGWGQPHGGG PRIO_PANTR 73 0 -
WGQPHGGGWGQPHGGG PRIO_HUMAN 73 0 -
WGQPHGGGWGQPHGGG O46648 76 0 -
WGQPHGGGWGQPHGGG PRIO_SHEEP 76 0 -
WGQPHGGGWGQPHGGG PRIO_CALJA 72 0 -
WGQPHGGGWGQPHGGG PRIO_BOVIN 76 0 -
WGQPHGGGWGQPHGGG PRP2_BOVIN 76 0 -
WGQPHGGGWGQPHGGG PRIO_ATEPA 72 0 -
WGQPHGGGWGQPHGGG PRIO_SAISC 72 0 -
WGQPHGGGWGQPHGGG PRIO_PREFR 73 0 -
WGQPHGGGWGQPHGGG PRIO_PONPY 73 0 -
WGQPHGGGWGQPHGGG O75942 73 0 -
WGQPHGGGWGQPHGGG PRIO_CAPHI 76 0 -
WGQPHGGSWGQPHGGG PRIO_CEBAP 72 0 -
WGQPHGGGWGQPHGGG PRIO_CAMDR 76 0 -
WGQPHGGGWGQPHGGG PRIO_FELCA 76 0 -
WGQPHGGGWGQPHGGG PRP1_TRAST 76 0 -
WGQPHGGGWGQPHGGG PRIO_RABIT 73 0 -
WGQPHGGGWGQPHGGG PRP2_TRAST 76 0 -
WGQPHGGGWGQPHGGG PRIO_PIG 76 0 -
WGQPHGGGWGQPHGGG PRIO_CANFA 76 0 -
WGQPHGGGWGQPHGGG PRIO_CRIGR 73 0 -
WGQPHGGGWGQPHGGG PRIO_CRIMI 73 0 -
WGQPHGGGWGQGGGTH Q15216 73 0 -
WGQPHGGGWGQPHGGG PRIO_RAT 73 0 -
WGQPHGGGWGQGGGTH PRIO_CERAE 73 0 -
WGQPHGGGWGQPHGGG PRIO_MUSPF 76 0 -
WGQPHGGGWGQPHGGG PRIO_MUSVI 76 0 -
WGQPHGGGWGQPHGGG PRIO_MESAU 73 0 -
WGQPHGGSWGQPHGGG PRIO_MOUSE 72 0 -
WGQPHGGGWGQPHGGG O46593 76 0 -
QPHPGGSSWGQPHGGS PRIO_TRIVU 80 4 -

Motif 5 width=20
Element Seqn Id St Int Rpt
MAGAAAAGAVVGGLGGYMLG PRIO_COLGU 112 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_MACFA 112 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_CEREL 115 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_ODOHE 115 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_GORGO 112 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_PANTR 112 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_HUMAN 112 23 -
VAGAAAAGAVVGGLGGYMLG O46648 115 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_SHEEP 115 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_CALJA 111 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_BOVIN 123 31 -
VAGAAAAGAVVGGLGGYMLG PRP2_BOVIN 115 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_ATEPA 111 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_SAISC 119 31 -
MAGAAAAGAVVGGLGGYMLG PRIO_PREFR 112 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_PONPY 112 23 -
MAGAAAAGAVVGGLGGYMLG O75942 144 55 -
VAGAAAAGAVVGGLGGYMLG PRIO_CAPHI 115 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_CEBAP 111 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_CAMDR 115 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_FELCA 115 23 -
VAGAAAAGAVVGGLGGYMLG PRP1_TRAST 123 31 -
VAGAAAAGAVVGGLGGYMLG PRIO_RABIT 111 22 -
VAGAAAAGAVVGGLGGYMLG PRP2_TRAST 115 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_PIG 116 24 -
VAGAAAAGAVVGGLGGYLLG PRIO_CANFA 115 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_CRIGR 112 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_CRIMI 112 23 -
MAGAAAAGAVVGGLGGYMLG Q15216 104 15 -
VAGAAAAGAVVGGLGGYMLG PRIO_RAT 112 23 -
MAGAAAAGAVVGGLGGYMLG PRIO_CERAE 104 15 -
VAGAAAAGAVVGGLGGYMLG PRIO_MUSPF 116 24 -
VAGAAAAGAVVGGLGGYMLG PRIO_MUSVI 116 24 -
MAGAAAAGAVVGGLGGYMLG PRIO_MESAU 112 23 -
VAGAAAAGAVVGGLGGYMLG PRIO_MOUSE 111 23 -
VAGAAAAGAVVGGLGGYMLG O46593 116 24 -
VAGAAAAGAVVGGLGGYMLG PRIO_TRIVU 117 21 -

Motif 6 width=20
Element Seqn Id St Int Rpt
DYEDRYYRENMYRYPNQVYY PRIO_COLGU 144 12 -
DYEDRYYRENMYRYPNQVYY PRIO_MACFA 144 12 -
DYEDRYYRENMYRYPNQVYY PRIO_CEREL 147 12 -
DYEDRYYRENMYRYPNQVYY PRIO_ODOHE 147 12 -
DYEDRYYRENMHRYPNQVYY PRIO_GORGO 144 12 -
DYEDRYYRENMHRYPNQVYY PRIO_PANTR 144 12 -
DYEDRYYRENMHRYPNQVYY PRIO_HUMAN 144 12 -
DYEDRYYRENMYRYPNQVYY O46648 147 12 -
DYEDRYYRENMYRYPNQVYY PRIO_SHEEP 147 12 -
DYEDRYYRENMYRYPNQVYY PRIO_CALJA 143 12 -
DYEDRYYRENMHRYPNQVYY PRIO_BOVIN 155 12 -
DYEDRYYRENMHRYPNQVYY PRP2_BOVIN 147 12 -
DYEDRYYRENMYRYPNQVYY PRIO_ATEPA 143 12 -
DYEDRYYRENMYRYPSQVYY PRIO_SAISC 151 12 -
DYEDRYYRENMYRYPNQVYY PRIO_PREFR 144 12 -
DYEDRYYRENMYRYPNQVYY PRIO_PONPY 144 12 -
DYEDRYYRENMHRYPNQVYY O75942 176 12 -
DYEDRYYRENMYRYPNQVYY PRIO_CAPHI 147 12 -
DYEDRYYRENMYRYPNQVYY PRIO_CEBAP 143 12 -
DYEDRYYRENMYRYPNQVYY PRIO_CAMDR 147 12 -
DYEDRYYRENMYRYPDQVYY PRIO_FELCA 147 12 -
DYEDRYYRENMYRYPNQVYY PRP1_TRAST 155 12 -
DYEDRYYRENMYRYPNQVYY PRIO_RABIT 143 12 -
DYEDRYYRENMYRYPNQVYY PRP2_TRAST 147 12 -
DYEDRYYRENMYRYPNQVYY PRIO_PIG 148 12 -
DCEDRYYRENMYRYPNQVYY PRIO_CANFA 147 12 -
DWEDRYYRENMNRYPNQVYY PRIO_CRIGR 144 12 -
DWEDRYYRENMNRYPNQVYY PRIO_CRIMI 144 12 -
DYEDRYYRENMHRYPNQVYY Q15216 136 12 -
DWEDRYYRENMYRYPNQVYY PRIO_RAT 144 12 -
DYEDRYYRENMYRYPNQVYY PRIO_CERAE 136 12 -
DYEDRYYRENMYRYPNQVYY PRIO_MUSPF 148 12 -
DYEDRYYRENMYRYPNQVYY PRIO_MUSVI 148 12 -
DWEDRYYRENMNRYPNQVYY PRIO_MESAU 144 12 -
DWEDRYYRENMYRYPNQVYY PRIO_MOUSE 143 12 -
DYEDRYYRENMYRYPEQVYY O46593 148 12 -
EYEDRYYRENQYRYPNQVMY PRIO_TRIVU 149 12 -

Motif 7 width=22
Element Seqn Id St Int Rpt
KGENFTETDVKMMERVVEQMCI PRIO_COLGU 194 30 -
KGENFTETDVKMMERVVEQMCI PRIO_MACFA 194 30 -
KGENFTETDIKMMERVVEQMCI PRIO_CEREL 197 30 -
KGENFTETDIKMMERVVEQMCI PRIO_ODOHE 197 30 -
KGENFTETDVKMMERVVEQMCI PRIO_GORGO 194 30 -
KGENFTETDVKMMERVVEQMCI PRIO_PANTR 194 30 -
KGENFTETDVKMMERVVEQMCI PRIO_HUMAN 194 30 -
KGENFTETDIKIMERVVEQMCI O46648 197 30 -
KGENFTETDIKIMERVVEQMCI PRIO_SHEEP 197 30 -
KGENFTETDVKMMERVVEQMCI PRIO_CALJA 193 30 -
KGENFTETDIKMMERVVEQMCI PRIO_BOVIN 205 30 -
KGENFTETDIKMMERVVEQMCI PRP2_BOVIN 197 30 -
KGENLTETDVKMMERVVEQMCI PRIO_ATEPA 193 30 -
KGENFTETDVKMMERVVEQMCI PRIO_SAISC 201 30 -
KGENFTETDVKMMERVVEQMCI PRIO_PREFR 194 30 -
KGENFTETDVKMMERVVEQMCI PRIO_PONPY 194 30 -
KGENFTETDVRMMERVVEQMCI O75942 226 30 -
KGENFTETDIKIMERVVEQMCI PRIO_CAPHI 197 30 -
KGENFTETDVKMMERVVEQMCI PRIO_CEBAP 193 30 -
KGENFTETDVKMMERVVEQMCI PRIO_CAMDR 197 30 -
KGENFTETDMKIMERVVEQMCV PRIO_FELCA 197 30 -
KGENFTETDIKMMERVVEQMCI PRP1_TRAST 205 30 -
KGENFTETDIKIMERVVEQMCI PRIO_RABIT 193 30 -
KGENFTETDIKMMERVVEQMCI PRP2_TRAST 197 30 -
KGENFTETDVKMIERVVEQMCI PRIO_PIG 198 30 -
KGENFTETDIKMMERVVEQMCI PRIO_CANFA 196 29 -
KGENFTETDVKMMERVVEQMCV PRIO_CRIGR 194 30 -
KGENFTETDVKMMERVVEQMCV PRIO_CRIMI 194 30 -
KGENFTETDVKMMERVVEQMCI Q15216 186 30 -
KGENFTETDVKMMERVVEQMCV PRIO_RAT 194 30 -
KGENFTETDVKMMERVVEQMCI PRIO_CERAE 186 30 -
KGENFTETDMKIMERVVEQMCV PRIO_MUSPF 198 30 -
KGENFTETDMKIMERVVEQMCV PRIO_MUSVI 198 30 -
KGENFTETDIKIMERVVEQMCT PRIO_MESAU 194 30 -
KGENFTETDVKMMERVVEQMCV PRIO_MOUSE 193 30 -
KGENFTETDMKIMERVVEQMCV O46593 198 30 -
KGENFTETDIKIMERVVEQMCI PRIO_TRIVU 199 30 -

Motif 8 width=19
Element Seqn Id St Int Rpt
VLFSSPPVILLISFLIFLI PRIO_COLGU 233 17 -
VLFSSPPVILLISFLIFLI PRIO_MACFA 233 17 -
ILFSSPPVILLISFLIFLI PRIO_CEREL 236 17 -
ILFSSPPVILLISFLIFLI PRIO_ODOHE 236 17 -
VLFSSPPVILLISFLIFLI PRIO_GORGO 233 17 -
VLFSSPPVILLISFLIFLI PRIO_PANTR 233 17 -
VLFSSPPVILLISFLIFLI PRIO_HUMAN 233 17 -
ILFSSPPVILLISFLIFLI O46648 236 17 -
ILFSSPPVILLISFLIFLI PRIO_SHEEP 236 17 -
VLFSSPPVILLISFLIFLI PRIO_CALJA 232 17 -
ILFSSPPVILLISFLIFLI PRIO_BOVIN 244 17 -
ILFSSPPVILLISFLIFLI PRP2_BOVIN 236 17 -
VLFSSPPVILLISFLIFLI PRIO_ATEPA 232 17 -
VLFSSPPVILLISFLIFLI PRIO_SAISC 240 17 -
VFFSSPPVILLISFLIFLI PRIO_PREFR 233 17 -
VLFSSPPVILLISFLIFLI PRIO_PONPY 233 17 -
VLFSSPPVILLISFLIFLI O75942 265 17 -
ILFSPPPVILLISFLIFLI PRIO_CAPHI 236 17 -
VLFSSPPVILLISFLIFLI PRIO_CEBAP 232 17 -
VIFSSPPVILLISFLIFLI PRIO_CAMDR 235 16 -
ILFSSPPVILLISFLIFLI PRIO_FELCA 236 17 -
ILFSSPPVILLISFLIFLI PRP1_TRAST 244 17 -
LLFSSPPVILLISFLIFLI PRIO_RABIT 232 17 -
ILFSSPPVILLISFLIFLI PRP2_TRAST 236 17 -
ILFSSPPVILLISFLLFLI PRIO_PIG 237 17 -
ILFSSPPVILLVSFLIFLI PRIO_CANFA 235 17 -
VLFSSPPVILLISFLIFLI PRIO_CRIGR 234 18 -
VLFSSPPVILLISFLIFLI PRIO_CRIMI 234 18 -
VLFSSPPVILLISFLIFLI Q15216 225 17 -
VLFSSPPVILLISFLIFLI PRIO_RAT 234 18 -
VLFSSPPVILLISFLIFLI PRIO_CERAE 225 17 -
ILFSPPPVILLISLLILLI PRIO_MUSPF 237 17 -
ILFSPPPVILLISLLILLI PRIO_MUSVI 237 17 -
VLFSSPPVILLISFLIFLM PRIO_MESAU 234 18 -
VLFSSPPVILLISFLIFLI PRIO_MOUSE 234 19 -
ILFSPPPVILLISLLILLI O46593 237 17 -
AFFSAPPVTLLFLSFLIFL PRIO_TRIVU 238 17 -