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PR00333

Identifier
HSVINTEGRLMP  [View Relations]  [View Alignment]  
Accession
PR00333
No. of Motifs
5
Creation Date
21-SEP-1993  (UPDATE 28-JUL-1999)
Title
Herpsevirus integral membrane protein signature
Database References

INTERPRO; IPR000785
Literature References
1. TELFORD, E.A.R., WATSON, M.S., MCBRIDE, K. AND DAVISON, A.
The DNA sequence of equine Herpesvirus.
J.VIROL. 189(1) 304-316 (1992).
 
2. CHEE, M.S., BANKIER, A.T., BECK, S., BOHNI, R., BROWN, C.M., CERNY, R.,
HORSNELL, T., HUTCHISON, C.A., KOUZARIDES, T., MARTIGNETTI, J.A., 
PREDDIE, E., SATCHWELL, S.C., TOMLINSON, P., WESTON, K.M. AND BARRELL, B.G.
Analysis of the protein-coding content of the sequence of human
cytomegalovirus strain AD169.
CURR.TOP.MICROBIOL.IMMUNOL. 154 125-169 (1990).
 
3. DAVISON, A.J. AND SCOTT, J.E. 
The complete DNA sequence of Varicella zoster virus.
GEN.VIROL. 67 1759-1816 (1986).

Documentation
The equine Herpesvirus EHV1 protein belongs to a family of sequences that
groups together HSV1 UL10, EHV1 52, VZV 50, EBV BBRF3, HVS1 39 and HCMV
UL100. Little is yet known about the properties of the protein. However,
its amino acid sequence is highly hydrophobic, containing 8 putative
membrane-spanning regions, and it is therefore believed to be either
membrane-associated or transmembrane.
 
HSVINTEGRLMP is a 5-element fingerprint that provides a signature for the
Herpesvirus integral membrane proteins. The fingerprint was derived from
an initial alignment of 5 sequences: the motifs were drawn from conserved
regions spanning the full alignment length. Two iterations on OWL21.1 were
required to reach convergence, at which point a true set comprising 7
sequences was identified.
 
An update on SPTR37_9f identified a true set of 22 sequences.
Summary Information
22 codes involving  5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
52222222222
400000
300000
200000
12345
True Positives
O36388        O39292        O39493        O40931        
O41956 P88927 P89433 Q83143
Q85041 Q85042 VGLM_EBV VGLM_HCMVA
VGLM_HSV11 VGLM_HSV6U VGLM_HSV6Z VGLM_HSV7J
VGLM_HSVBC VGLM_HSVE2 VGLM_HSVEB VGLM_HSVSA
VGLM_MCMVK VGLM_VZVD
Sequence Titles
O36388      INTEGRAL MEMBRANE PROTEIN - ALCELAPHINE HERPESVIRUS 1 (WILDEBEEST HERPESVIRUS). 
O39292 COUNTERPART OF HSV-1 GENE UL10 AND VZV GENE 50 - EQUINE HERPESVIRUS 4.
O39493 GLYCOPROTEIN M - BOVINE HERPESVIRUS 1.
O40931 GLYCOPROTEIN M - KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) (HUMAN HERPESVIRUS 8).
O41956 GLYCOPROTEIN M - MURINE HERPESVIRUS 68.
P88927 ORF 39 - KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) (HUMAN HERPESVIRUS 8).
P89433 VIRION GLYCOPROTEIN M - HERPES SIMPLEX VIRUS (TYPE 2).
Q83143 SIMILAR TO HCMV UL100 - MOUSE CYTOMEGALOVIRUS 1.
Q85041 UL10 - PSEUDORABIES VIRUS.
Q85042 UL10 - PSEUDORABIES VIRUS.
VGLM_EBV GLYCOPROTEIN M - EPSTEIN-BARR VIRUS (STRAIN B95-8) (HUMAN HERPESVIRUS 4).
VGLM_HCMVA GLYCOPROTEIN M - HUMAN CYTOMEGALOVIRUS (STRAIN AD169).
VGLM_HSV11 GLYCOPROTEIN M - HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17).
VGLM_HSV6U GLYCOPROTEIN M - HERPES SIMPLEX VIRUS (TYPE 6 / STRAIN UGANDA-1102).
VGLM_HSV6Z GLYCOPROTEIN M - HERPES SIMPLEX VIRUS (TYPE 6 / STRAIN Z29).
VGLM_HSV7J GLYCOPROTEIN M - HERPES SIMPLEX VIRUS (TYPE 7 / STRAIN JI) (HHV7).
VGLM_HSVBC GLYCOPROTEIN M - BOVINE HERPESVIRUS TYPE 1 (STRAIN COOPER).
VGLM_HSVE2 GLYCOPROTEIN M - EQUINE HERPESVIRUS TYPE 2 (STRAIN 86/87) (EHV-2).
VGLM_HSVEB GLYCOPROTEIN M - EQUINE HERPESVIRUS TYPE 1 (STRAIN AB4P) (EHV-1).
VGLM_HSVSA GLYCOPROTEIN M - HERPESVIRUS SAIMIRI (STRAIN 11).
VGLM_MCMVK GLYCOPROTEIN M - MURINE CYTOMEGALOVIRUS (STRAIN K181).
VGLM_VZVD GLYCOPROTEIN M - VARICELLA-ZOSTER VIRUS (STRAIN DUMAS) (VZV).
Scan History
OWL21_1    2  50   NSINGLE    
OWL26_0 1 100 NSINGLE
SPTR37_9f 3 50 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
DTLNWRIWIIQVMMF VIMP_VZVD 30 30 -
EGINWRTWLVQVFCF VIMP_HSVEB 25 25 -
DTFMLRTWIQLLVLF VIMP_HSVSA 7 7 -
DKVNTRTWSASIVFM VIMP_HCMVA 6 6 -
ARTAWWVWCVQVATF VIMP_HSV11 21 21 -

Motif 2 width=15
Element Seqn Id St Int Rpt
LIAASSEYTGIPCFY VIMP_VZVD 55 10 -
LVTASLPQTGYPCFY VIMP_HSVEB 50 10 -
PIAASVEGLGFPCYF VIMP_HSVSA 32 10 -
LVLSNFPHLGYPCVY VIMP_HCMVA 31 10 -
LVLASVFRARFPCFY VIMP_HSV11 46 10 -

Motif 3 width=20
Element Seqn Id St Int Rpt
TLFWGLLSLWLLNAVVLLLA VIMP_VZVD 155 85 -
TLVLGTLATWLLQVVILLLS VIMP_HSVEB 154 89 -
MLFIGIARMWTLQLFIHVLS VIMP_HSVSA 128 81 -
TAFLFILSMDTFQLFTLTMS VIMP_HCMVA 126 80 -
TLIAGNVCSWLLQITVLLLA VIMP_HSV11 138 77 -

Motif 4 width=21
Element Seqn Id St Int Rpt
YKQIGVAATLYLGHFATSVIF VIMP_VZVD 175 0 -
HKQAVLGAAVYVVHFVSLVFF VIMP_HSVEB 174 0 -
YKHVMLAAFIYFLHFCLSYMH VIMP_HSVSA 148 0 -
FRLPSMIAFMAAVHFFCLTIF VIMP_HCMVA 146 0 -
HRISQLAHLVYVLHFACLVYF VIMP_HSV11 158 0 -

Motif 5 width=22
Element Seqn Id St Int Rpt
YLIVSELILAHYIHVLIGPSLG VIMP_VZVD 283 87 -
FLIIVELIVSHYVHVLVGPALA VIMP_HSVEB 282 87 -
WYMMTEMFLQDYLKLQFGFYLG VIMP_HSVSA 255 86 -
YFLLIEAVFFQYVKVQFGYHLG VIMP_HCMVA 250 83 -
LLLVVEGVLCHYVRVLVGPHLG VIMP_HSV11 266 87 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
DTINLRIWLVSIICA VGLM_HSV6U 7 7 -
DTINLRIWLVSIICA VGLM_HSV6Z 7 7 -
EGINWRTWLVQVFCF VGLM_HSVEB 26 26 -
AAVHWRLWLAQVGVF O39493 8 8 -
AAVHWRLWLAQVGVF VGLM_HSVBC 8 8 -
DTFMLRTWIQLLVLF VGLM_HSVSA 8 8 -
EGINWKMWLVQVFCF O39292 26 26 -
DVINMRIWVLSIICA VGLM_HSV7J 7 7 -
DRMNLRTWTMAIACC VGLM_MCMVK 13 13 -
EAVSWRSWLIEVCGF Q85042 140 140 -
EAVSWRSWLIEVCGF Q85041 8 8 -
DIFILHIWLKLMGCY O36388 7 7 -
DRMNLRTWTMAIACC Q83143 31 31 -
DTLNWRIWIIQVMMF VGLM_VZVD 31 31 -
DRFLMSSWVKLLFVA P88927 7 7 -
DRFLMSSWVKLLFVA O40931 7 7 -
DLFIYKTWFKLLVLY VGLM_HSVE2 7 7 -
DSFLLKSWTNLLALL O41956 18 18 -
DTFVYRTWVKTLVVY VGLM_EBV 7 7 -
ARTAWWVWCVQVATF VGLM_HSV11 22 22 -
ARAAWWVWCVQVATF P89433 22 22 -
DKVNTRTWSASIVFM VGLM_HCMVA 7 7 -

Motif 2 width=15
Element Seqn Id St Int Rpt
LIAINFPNLGFPCAY VGLM_HSV6U 32 10 -
LIAINFPNLGFPCAY VGLM_HSV6Z 32 10 -
LVTASLPQTGYPCFY VGLM_HSVEB 51 10 -
LIGAASPGAGLPCFY O39493 33 10 -
LIGAASPGAGLPCFY VGLM_HSVBC 33 10 -
PIAASVEGLGFPCYF VGLM_HSVSA 33 10 -
LVTASLQKTGYPCFY O39292 51 10 -
LVAVHFPNLGFPCAY VGLM_HSV7J 32 10 -
SVAAHFPGIGFPCYY VGLM_MCMVK 38 10 -
LIFASLPEMGFPCFY Q85042 165 10 -
LIFASLPEMGFPCFY Q85041 33 10 -
PIAAMFPNLGFPCYY O36388 32 10 -
SVAAHFPGIGFPCYY Q83143 56 10 -
LIAASSEYTGIPCFY VGLM_VZVD 56 10 -
PMAATYEGLGFPCYF P88927 32 10 -
PMAATYEGLGFPCYF O40931 32 10 -
PIAASFPGLGFPCYY VGLM_HSVE2 32 10 -
PILASFRGVGFPCYF O41956 43 10 -
PITAMFPNLGYPCYF VGLM_EBV 32 10 -
LVLASVFRARFPCFY VGLM_HSV11 47 10 -
LVLASVFRDRFPCLY P89433 47 10 -
LVLSNFPHLGYPCVY VGLM_HCMVA 32 10 -

Motif 3 width=20
Element Seqn Id St Int Rpt
SCFQFILIMDTFQLFVTALS VGLM_HSV6U 126 79 -
SCFQFILIMDTFQLFVTALS VGLM_HSV6Z 126 79 -
TLVLGTLATWLLQVVILLLS VGLM_HSVEB 155 89 -
ALLLGALAAWTLQAAVLLLS O39493 135 87 -
ALLLGALAAWTLQAAVLLLS VGLM_HSVBC 135 87 -
MLFIGIARMWTLQLFIHVLS VGLM_HSVSA 129 81 -
TLVLGTLTTWLLQVVILLLS O39292 155 89 -
SCFQFVLTMDTYQFFVTCLS VGLM_HSV7J 126 79 -
TCFTFVLTMDTFQIFLLSLS VGLM_MCMVK 133 80 -
TLMLGALCAWTLQAVVLLMA Q85042 264 84 -
TLMLGALCAWTLQAVVLLMA Q85041 132 84 -
LLYMAVLKLWTIQLYIHTLS O36388 127 80 -
TCFTFVLTMDTFQIFLLSLS Q83143 151 80 -
TLFWGLLSLWLLNAVVLLLA VGLM_VZVD 156 85 -
VLYVAILRMWSMQLFIHVLS P88927 128 81 -
VLYVAILRMWSMQLFIHVLS O40931 128 81 -
LILIGMWRMWTIQLFIQTLS VGLM_HSVE2 128 81 -
TLYLSIARLWTLQLFVHVLS O41956 139 81 -
VLFLAILKLWSIQVFIQVLS VGLM_EBV 127 80 -
TLIAGNVCSWLLQITVLLLA VGLM_HSV11 139 77 -
TLIAGNVCAWLLQITVLLLA P89433 139 77 -
TAFLFILSMDTFQLFTLTMS VGLM_HCMVA 127 80 -

Motif 4 width=21
Element Seqn Id St Int Rpt
FRLVALGAFAYCIFFVCFTTF VGLM_HSV6U 146 0 -
FRLVALGAFAYSIFFVCFTTF VGLM_HSV6Z 146 0 -
HKQAVLGAAVYVVHFVSLVFF VGLM_HSVEB 175 0 -
HKIMVLAAATYLAHLAPPAAF O39493 155 0 -
HKIMVLAAATYLAHLAPPAAF VGLM_HSVBC 155 0 -
YKHVMLAAFIYFLHFCLSYMH VGLM_HSVSA 149 0 -
HKQVVLAAAAYIVHFVALVFF O39292 175 0 -
FRLVTLAAFTYCLFFICFTAF VGLM_HSV7J 146 0 -
FRLPSMVAFSKCMYFMCLTAF VGLM_MCMVK 153 0 -
HKQAGLAAAAYITHFVFLALF Q85042 284 0 -
HKQAGLAAAAYITHFVFLALF Q85041 152 0 -
YKHIYLAAFVYCLHWLLSMVY O36388 147 0 -
FRLPSMVAFSKCMYFMCLTAN Q83143 171 0 -
YKQIGVAATLYLGHFATSVIF VGLM_VZVD 176 0 -
YKHVLMAAFVYCIHFCISFAH P88927 148 0 -
YKHVLMAAFVYCIHFCISFAH O40931 148 0 -
YKHIYLSAFVYLIHFLLSFLH VGLM_HSVE2 148 0 -
FKQIFLAAFVYLFHFMLSYVH O41956 159 0 -
YKHVFLSAFVYFLHFLASVLH VGLM_EBV 147 0 -
HRISQLAHLVYVLHFACLVYF VGLM_HSV11 159 0 -
HRISQLAHLIYVLHFACLVYL P89433 159 0 -
FRLPSMIAFMAAVHFFCLTIF VGLM_HCMVA 147 0 -

Motif 5 width=22
Element Seqn Id St Int Rpt
YSIVIEAVLVRYVKPLFGYYVG VGLM_HSV6U 250 83 -
YSIVIEAVLVRYVKPLFGYYVG VGLM_HSV6Z 250 83 -
FLIIVELIVSHYVHVLVGPALA VGLM_HSVEB 283 87 -
FLVLTELVLSRYTQVLPGPAFG O39493 263 87 -
FLVLTELVLSRYTQVLPGPAFG VGLM_HSVBC 263 87 -
WYMMTEMFLQDYLKLQFGFYLG VGLM_HSVSA 256 86 -
FLIIVELVVSHYVHVLIGPALA O39292 283 87 -
YSLVIELILHQYVKVQFGLHFG VGLM_HSV7J 250 83 -
YFSIIESVLSRYMKVQFGYHIG VGLM_MCMVK 257 83 -
LMVFVEVVVSGYVQVLPTPAFC Q85042 386 81 -
LMVFVEVVVSGYVQVLPTPAFC Q85041 254 81 -
WYFVTEFWLSKYLPRQFGFYFG O36388 254 86 -
YFSIIESVLSRYMKVQFGYHIG Q83143 275 83 -
YLIVSELILAHYIHVLIGPSLG VGLM_VZVD 284 87 -
WYINTEFFLVKFMRRQVGFYVG P88927 255 86 -
WYINTEFFLVKFMRRQVGFYVG O40931 255 86 -
WVLLTELYLVKYMTFVMGFYLG VGLM_HSVE2 255 86 -
WHIGAEVFLAKYLRHHVGFYIG O41956 266 86 -
WYILTEVWLASFLRHNFGFYCG VGLM_EBV 254 86 -
LLLVVEGVLCHYVRVLVGPHLG VGLM_HSV11 267 87 -
LLLVVEGVLCHYVRVLVGPHLG P89433 267 87 -
YFLLIEAVFFQYVKVQFGYHLG VGLM_HCMVA 251 83 -