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PR00319

Identifier
GPROTEINB  [View Relations]  [View Alignment]  
Accession
PR00319
No. of Motifs
4
Creation Date
20-SEP-1993  (UPDATE 27-JUN-1999)
Title
Beta G-protein (transducin) signature
Database References

INTERPRO; IPR001632
Literature References
1. LINDER, M.E. AND GILMAN, A.G.
G proteins.
SCI.AM. 70-77 (1993).
 
2. KAZIRO, Y., ITOH, H., KOZASA, T., NAKAFUKU, M. AND SATOH, T.
Structure and function of signal-transducing GTP-binding proteins.
ANNU.REV.BIOCHEMISTRY 60 349-400 (1991).
 
3. SIMON, M.I., STRATHMANN, M.P. AND GAUTAM, N.
Diversity of G proteins in signal transduction.
SCIENCE 252 802-808 (1993).
 
4. CLAPHAM, D.E. AND NEER, E.J.
New roles for G protein beta-gamma dimers in transmembrane signalling.
NATURE 365 403-406 (1993)
 
5. LUPAS, A.N., LUPAS, J.M. AND STOCK, J.B.
Do G protein subunits associate via a 3-stranded coiled coil?
FEBS LETT. 314 105-108 (1992).
 
6. DURONIO, R.J., GORDON, J.I. AND BOGUSKI, M.S.
Comparative analysis of the beta-transducin family with identification of
several new members including pwp1, a non-essential gene of Saccharomyces
cerevisiae that is divergently transcribed from nmt1.
PROTEINS 13(1) 41-56 (1992).
 
7. VAN DER VOORN, L. AND PLOEGH, H.L.
The WD-40 repeat.
FEBS LETT. 307(2) 131-134 (1992). 

Documentation
Guanine nucleotide binding proteins (G proteins) are a family of membrane-
associated proteins that couple extracellularly-activated integral-membrane
receptors to intracellular effectors, such as ion channels and enzymes that
vary the concentration of second messenger molecules [1-3]. G proteins are
composed of 3 subunits (alpha, beta and gamma) which, in the resting state,
associate as a trimer at the inner face of the plasma membrane. The alpha
subunit has a molecule of guanosine diphosphate (GDP) bound to it:
stimulation of the G protein by an activated receptor leads to its exchange
for GTP (guanosine triphosphate). This results in the separation of the
alpha from the beta and gamma subunits, which always remain tightly
associated as a dimer. Both the alpha and beta-gamma subunits are then able
to interact with effectors, either individually or in a cooperative manner.
The intrinsic GTPase activity of the alpha subunit hydrolyses the bound GTP
to GDP. This returns the alpha subunit to its inactive conformation and
allows it to reassociate with the beta-gamma subunit, thus restoring the
system to its resting state.
 
Although originally thought to be a passive attenuator and membrane anchor
for the activated alpha subunit, the beta-gamma subunit is now recognised
as playing an active role in a number of different G protein-coupled
signalling events [4]. It has been shown to modulate the activity of some
isoforms of adenylyl cyclase, phospholipase C, and some ion channels. It is
involved in receptor phosphorylation via specific kinases, and has been
implicated in the p21ras-dependent activation of the MAP kinase cascade. 
It is also highly likely that it contributes to the recognition of specific
receptors by the G protein. No atomic structure is yet available for beta-
gamma subunits, but it has been proposed that they interact both with each
other and with other proteins via a coiled coil motif in their N-terminal
regions [5].
 
Four different G protein beta subunits have been identified in mammals,
and some have also been identified in certain invertebrate species. Beta
subunits contain around 340 amino acids, with apparent molecular weights
of 35-36 kDa. Their sequences are highly conserved between species, 
implying that they perform a fundamentally important role in the 
organisation of G protein linked systems [6]. The sequences display tandem
repeats of a 40-residue domain containing a characteristic Trp-Asp motif
(the so-called WD-40 repeat [7]).
 
GPROTEINB is a 4-element fingerprint that provides a signature for the 
G-beta subunits. The fingerprint was derived from an initial alignment of
6 sequences: the motifs were drawn from conserved regions within the first
two-thirds of the alignment, motif 2 including part of a WD-40 repeat. Two
iterations on OWL21.1 were required to reach convergence, at which point a
true set comprising 12 sequences was identified. Three partial matches were
also found, including 2 G-beta-like proteins and murine nedd-1 protein,
which is known to share partial similarity with the G-beta subunits.
 
An update on SPTR37_9f identified a true set of 33 sequences, and 1
partial match.
Summary Information
  33 codes involving  4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
433333333
30000
21100
1234
True Positives
GBB1_CAEEL    GBB1_DROME    GBB1_HOMAM    GBB1_HUMAN    
GBB1_RAT GBB1_TOBAC GBB1_XENLA GBB2_DROME
GBB2_HUMAN GBB2_MOUSE GBB2_RAT GBB2_TOBAC
GBB3_CANFA GBB3_HUMAN GBB3_RAT GBB3_TOBAC
GBB4_MOUSE GBB5_CAEEL GBB5_HUMAN GBB5_MOUSE
GBB_ARATH GBB_CRYPA GBB_DICDI GBB_LOLFO
GBB_LYMST GBB_MAIZE GBB_NICPL GBB_ORYSA
GBB_SCHPO GBB_SOLTU GBB_YEAST O64944
O74214
True Positive Partials
Codes involving 2 elements
O74855
Sequence Titles
GBB1_CAEEL  GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 1 - CAENORHABDITIS ELEGANS. 
GBB1_DROME GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 1 - DROSOPHILA MELANOGASTER (FRUIT FLY).
GBB1_HOMAM GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 1 (TRANSDUCIN BETA CHAIN 1) - HOMARUS AMERICANUS (AMERICAN LOBSTER).
GBB1_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 1 (TRANSDUCIN BETA CHAIN 1) - HOMO SAPIENS (HUMAN), MUS MUSCULUS (MOUSE), BOS TAURUS (BOVINE), AND CANIS FAMILIARIS (DOG).
GBB1_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 1 (TRANSDUCIN BETA CHAIN 1) - RATTUS NORVEGICUS (RAT).
GBB1_TOBAC GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 1 - NICOTIANA TABACUM (COMMON TOBACCO).
GBB1_XENLA GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 1 (TRANSDUCIN BETA CHAIN 1) (XGBETA1) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
GBB2_DROME GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 2 - DROSOPHILA MELANOGASTER (FRUIT FLY).
GBB2_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 2 (TRANSDUCIN BETA CHAIN 2) - HOMO SAPIENS (HUMAN).
GBB2_MOUSE GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 2 (TRANSDUCIN BETA CHAIN 2) - MUS MUSCULUS (MOUSE).
GBB2_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 2 (TRANSDUCIN BETA CHAIN 2) - RATTUS NORVEGICUS (RAT).
GBB2_TOBAC GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 2 - NICOTIANA TABACUM (COMMON TOBACCO).
GBB3_CANFA GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 3 (TRANSDUCIN BETA CHAIN 3) - CANIS FAMILIARIS (DOG).
GBB3_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 3 (TRANSDUCIN BETA CHAIN 3) - HOMO SAPIENS (HUMAN).
GBB3_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) BETA SUBUNIT 3 (TRANSDUCIN BETA CHAIN 3) - RATTUS NORVEGICUS (RAT).
GBB3_TOBAC GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - NICOTIANA TABACUM (COMMON TOBACCO).
GBB4_MOUSE GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 4 (TRANSDUCIN BETA CHAIN 4) - MUS MUSCULUS (MOUSE).
GBB5_CAEEL GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 5 - CAENORHABDITIS ELEGANS.
GBB5_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 5 (TRANSDUCIN BETA CHAIN 5) - HOMO SAPIENS (HUMAN).
GBB5_MOUSE GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT 5 (TRANSDUCIN BETA CHAIN 5) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
GBB_ARATH GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
GBB_CRYPA GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - CRYPHONECTRIA PARASITICA (CHESNUT BLIGHT FUNGUS) (ENDOTHIA PARASITICA).
GBB_DICDI GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
GBB_LOLFO GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - LOLIGO FORBESI (NORTHERN EUROPEAN SQUID).
GBB_LYMST GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - LYMNAEA STAGNALIS (GREAT POND SNAIL).
GBB_MAIZE GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - ZEA MAYS (MAIZE).
GBB_NICPL GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - NICOTIANA PLUMBAGINIFOLIA (LEADWORT-LEAVED TOBACCO).
GBB_ORYSA GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - ORYZA SATIVA (RICE).
GBB_SCHPO GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
GBB_SOLTU GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - SOLANUM TUBEROSUM (POTATO).
GBB_YEAST GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O64944 G PROTEIN BETA SUBUNIT - AVENA FATUA.
O74214 G-PROTEIN BETA SUBUNIT - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).

O74855 TRP-ASP REPEAT CONTAINING PROTEIN - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
Scan History
OWL21_1    2  100  NSINGLE    
OWL23_2 1 100 NSINGLE
OWL28_0 2 200 NSINGLE
SPTR37_9f 2 40 NSINGLE
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
LRGHLAKIYAMHWATDS GBB3_HUMAN 50 50 -
LRGHLAKIYAMHWGTDS GBB2_HUMAN 50 50 -
LRGHLAKIYAMHWGTDS GBB1_HUMAN 50 50 -
LRGHLAKIYAMHWASDS GBB_LOLFO 51 51 -
LKGHINKVNSVHFAGDS GBB2_DROME 54 54 -
LKGHNNKISDFRWSRDS GBB_YEAST 87 87 -

Motif 2 width=15
Element Seqn Id St Int Rpt
LVSASQDGKLIVWDS GBB3_HUMAN 69 2 -
LVSASQDGKLIIWDS GBB2_HUMAN 69 2 -
LVSASQDGKLIIWDS GBB1_HUMAN 69 2 -
LVSASQDGKLIVWDG GBB_LOLFO 70 2 -
CVTGSLDGKLIIWDT GBB2_DROME 73 2 -
ILSASQDGFMLIWDS GBB_YEAST 106 2 -

Motif 3 width=16
Element Seqn Id St Int Rpt
KVHAIPLRSSWVMTCA GBB3_HUMAN 88 4 -
KVHAIPLRSSWVMTCA GBB2_HUMAN 88 4 -
KVHAIPLRSSWVMTCA GBB1_HUMAN 88 4 -
KVHAIPLRSSWVMTCA GBB_LOLFO 89 4 -
KVQIIPLRSAWVMTVA GBB2_DROME 92 4 -
KQNAIPLDSQWVLSCA GBB_YEAST 125 4 -

Motif 4 width=18
Element Seqn Id St Int Rpt
PSGNFVACGGLDNMCSIY GBB3_HUMAN 106 2 -
PSGNFVACGGLDNICSIY GBB2_HUMAN 106 2 -
PSGNYVACGGLDNICSIY GBB1_HUMAN 106 2 -
PSGNYVACGGLDNICSIY GBB_LOLFO 107 2 -
PSGNFVACGGMDNQCTVY GBB2_DROME 110 2 -
PSSTLVASAGLNNNCTIY GBB_YEAST 143 2 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
LRGHLAKIYAMHWATDS GBB3_HUMAN 50 50 -
LRGHLAKIYAMHWGTDS GBB2_MOUSE 51 51 -
LRGHLAKIYAMHWGTDS GBB2_HUMAN 50 50 -
LRGHLAKIYAMHWGTDS GBB1_HUMAN 50 50 -
LRGHLAKIYAMHWGTDS GBB1_RAT 51 51 -
LRGHLAKIYAMHWATDS GBB3_CANFA 51 51 -
LRGHLAKIYAMHWATDS GBB3_RAT 51 51 -
LRGHLAKIYAMHWASDS GBB_LYMST 52 52 -
LRGHLAKIYAMHWGSDS GBB1_HOMAM 51 51 -
LRGHLAKIYAMHWASDS GBB_LOLFO 51 51 -
LRGHLAKIYAMHWASDS GBB1_CAEEL 51 51 -
LRGHLAKIYAMHWGNDS GBB1_DROME 51 51 -
LRGHLAKIYAMHWGTDS GBB1_XENLA 51 51 -
LRGHLAKIYAMHWGYDS GBB4_MOUSE 51 51 -
LKGHLAKIYAMHWSTDR GBB_CRYPA 67 67 -
LKGHLAKIYAMHWSTDR O74214 61 61 -
LKGHLAKIYAMHWAEDN GBB_DICDI 58 58 -
LRGHLAKIYDMHWGTDS GBB2_RAT 51 51 -
LQGHTGKVYSLDWTPEK GBB3_TOBAC 61 61 -
LQGHTGKVYSLDWTPEK GBB1_TOBAC 61 61 -
LQGHTGKVYSLDWTPEK GBB2_TOBAC 61 61 -
LQGHTGKVYSLDWTPEK GBB_SOLTU 61 61 -
LQGHTGKVYSLDWTPEK GBB_NICPL 61 61 -
LQGHTGKVYSLDWTPER GBB_ARATH 61 61 -
LQGHSGKVYSLDWTPEK GBB_ORYSA 62 62 -
LQGHSGKVYSLDWTPEK GBB_MAIZE 62 62 -
LQGHSGKVYSLDWTPEK O64944 62 62 -
LKGHGNKVLCMDWCKDK GBB5_HUMAN 59 59 -
LKGHGNKVLCMDWCKDK GBB5_MOUSE 59 59 -
LKGHVGKVLCMDWSLDK GBB5_CAEEL 64 64 -
LKGHINKVNSVHFAGDS GBB2_DROME 54 54 -
LKGHNNKISDFRWSRDS GBB_YEAST 87 87 -
LKNKLGKIPDIDISTDG GBB_SCHPO 29 29 -

Motif 2 width=15
Element Seqn Id St Int Rpt
LVSASQDGKLIVWDS GBB3_HUMAN 69 2 -
LVSASQDGKLIIWDS GBB2_MOUSE 70 2 -
LVSASQDGKLIIWDS GBB2_HUMAN 69 2 -
LVSASQDGKLIIWDS GBB1_HUMAN 69 2 -
LVSASQDGKLIIWDS GBB1_RAT 70 2 -
LVSASQDGKLIVWDT GBB3_CANFA 70 2 -
LVSASQDGKLIVWDT GBB3_RAT 70 2 -
LVSASQDGKLIVWDG GBB_LYMST 71 2 -
LVSASQDGKLIVWDS GBB1_HOMAM 70 2 -
LVSASQDGKLIVWDG GBB_LOLFO 70 2 -
LVSASQDGKLIVWDS GBB1_CAEEL 70 2 -
LVSASQDGKLIVWDS GBB1_DROME 70 2 -
LVSASQDGKLIIWDS GBB1_XENLA 70 2 -
LVSASQDGKLIIWDS GBB4_MOUSE 70 2 -
LVSASQDGKLIIWDA GBB_CRYPA 86 2 -
LVSASQDGKLIIWDA O74214 80 2 -
LVSASQDGKLLVWDG GBB_DICDI 77 2 -
LVSAAQDGKLIIWDS GBB2_RAT 70 2 -
IVSASQDGRLIVWNA GBB3_TOBAC 80 2 -
IVSASQDGRLIVWNA GBB1_TOBAC 80 2 -
IVSASQDGRLIVWNA GBB2_TOBAC 80 2 -
IVSASQDGRLIVWNA GBB_SOLTU 80 2 -
IVSASQDGRLIVWNA GBB_NICPL 80 2 -
IVSASQDGRLIVWNA GBB_ARATH 80 2 -
IVSASQDGRLIVWNA GBB_ORYSA 81 2 -
IVSASQDGRLIVWNA GBB_MAIZE 81 2 -
IVSASQDGRLIVWNA O64944 81 2 -
IVSSSQDGKVIVWDS GBB5_HUMAN 78 2 -
IVSSSQDGKVIVWDS GBB5_MOUSE 78 2 -
IVSSSQDGKVIVWDG GBB5_CAEEL 83 2 -
CVTGSLDGKLIIWDT GBB2_DROME 73 2 -
ILSASQDGFMLIWDS GBB_YEAST 106 2 -
LLSASTNDVLLVWDL GBB_SCHPO 48 2 -

Motif 3 width=16
Element Seqn Id St Int Rpt
KVHAIPLRSSWVMTCA GBB3_HUMAN 88 4 -
KVHAIPLRSSWVMTCA GBB2_MOUSE 89 4 -
KVHAIPLRSSWVMTCA GBB2_HUMAN 88 4 -
KVHAIPLRSSWVMTCA GBB1_HUMAN 88 4 -
KVHAIPLRSSWVMTCA GBB1_RAT 89 4 -
KVHAIPLRSSWVMTCA GBB3_CANFA 89 4 -
KVHAIPLRSSWVMTCA GBB3_RAT 89 4 -
KVHAIPLRSSWVMTCA GBB_LYMST 90 4 -
KVHAIPLRSSWVMTCA GBB1_HOMAM 89 4 -
KVHAIPLRSSWVMTCA GBB_LOLFO 89 4 -
KVHAIPLRSSWVMTCA GBB1_CAEEL 89 4 -
KVHAIPLRSSWVMTCA GBB1_DROME 89 4 -
KVHAIPLRSSWVMTCA GBB1_XENLA 89 4 -
KMHAIPLRSSWVMTCA GBB4_MOUSE 89 4 -
KVHAIPLRSSWVMTCA GBB_CRYPA 105 4 -
KVHAIPLRSSWVMTCA O74214 99 4 -
KVHAIPLRSSWVMTCA GBB_DICDI 96 4 -
KVHVIPLRSSWVKTCA GBB2_RAT 89 4 -
KTHAIKLPCAWVMTCA GBB3_TOBAC 99 4 -
KTHAIKLPCAWVMTCA GBB1_TOBAC 99 4 -
KTHAIKLPCAWVMTCA GBB2_TOBAC 99 4 -
KTHAIKLPCAWVMTCA GBB_SOLTU 99 4 -
KTHAIKLPCAWVMTCA GBB_NICPL 99 4 -
KTHAIKLPCAWVMTCA GBB_ARATH 99 4 -
KTHAIKLHCPWVMTCA GBB_ORYSA 100 4 -
KTHAIKLHCPWVMACA GBB_MAIZE 100 4 -
KTHAIKLHCPWVITCA O64944 100 4 -
KEHAVTMPCTWVMACA GBB5_HUMAN 97 4 -
KEHAVTMPCTWVMACA GBB5_MOUSE 97 4 -
KEHALTMPTTWVMACA GBB5_CAEEL 102 4 -
KVQIIPLRSAWVMTVA GBB2_DROME 92 4 -
KQNAIPLDSQWVLSCA GBB_YEAST 125 4 -
KVAFFEAPSVWIMTCA GBB_SCHPO 67 4 -

Motif 4 width=18
Element Seqn Id St Int Rpt
PSGNFVACGGLDNMCSIY GBB3_HUMAN 106 2 -
PSGNFVACGGLDNICSIY GBB2_MOUSE 107 2 -
PSGNFVACGGLDNICSIY GBB2_HUMAN 106 2 -
PSGNYVACGGLDNICSIY GBB1_HUMAN 106 2 -
PSGNYVACGGLDNICSIY GBB1_RAT 107 2 -
PSGNFVACGGLDNMCSIY GBB3_CANFA 107 2 -
PSGNFVACGGLDNMCSIY GBB3_RAT 107 2 -
PSGNFVACGGLDNICSIY GBB_LYMST 108 2 -
PSGSYVACGGLDNICSIY GBB1_HOMAM 107 2 -
PSGNYVACGGLDNICSIY GBB_LOLFO 107 2 -
PSGSFVACGGLDNICSIY GBB1_CAEEL 107 2 -
PSGSYVACGGLDNMCSIY GBB1_DROME 107 2 -
PSGNYVACGGLDNICPIY GBB1_XENLA 107 2 -
PSGNYVACGGLDNICSIY GBB4_MOUSE 107 2 -
PSGNYVACGGLDNICSIY GBB_CRYPA 123 2 -
PSGNYVACGGLDNICSIY O74214 117 2 -
PTANFVACGGLDNICSIY GBB_DICDI 114 2 -
PSGNFVACGGLDNNCSIY GBB2_RAT 107 2 -
PSGQSVACGGLDSVCSIY GBB3_TOBAC 117 2 -
PSGQSVACGGLDSVCSIF GBB1_TOBAC 117 2 -
PSGQSVACGGLDSVCSIF GBB2_TOBAC 117 2 -
PSGQSVACGGLDSACSIF GBB_SOLTU 117 2 -
PSGHSVACGGLDSVCSIF GBB_NICPL 117 2 -
PNGQSVACGGLDSVCSIF GBB_ARATH 117 2 -
PNGQSVACGGLDSACSIF GBB_ORYSA 118 2 -
PNGQSVACGGLDSACSIF GBB_MAIZE 118 2 -
PNGQSVACGGLNSACSIF O64944 118 2 -
PSGCAIACGGLDNKCSVY GBB5_HUMAN 115 2 -
PSGCAIACGGLDNKCSVY GBB5_MOUSE 115 2 -
PSSQMIACGGLDNKCSVV GBB5_CAEEL 120 2 -
PSGNFVACGGMDNQCTVY GBB2_DROME 110 2 -
PSSTLVASAGLNNNCTIY GBB_YEAST 143 2 -
PSTKSIAAGGLNNFCVVY GBB_SCHPO 85 2 -