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PR00279

Identifier
BACTRLTOXIN  [View Relations]  [View Alignment]  
Accession
PR00279
No. of Motifs
2
Creation Date
06-JUL-1994  (UPDATE 03-JUL-1999)
Title
Bacterial toxin signature
Database References
PRINTS; PR01898 SAGSUPRFAMLY
PROSITE; PS00277 STAPH_STREP_TOXIN_1; PS00278 STAPH_STREP_TOXIN_2
BLOCKS; BL00277
INTERPRO; IPR001961
Literature References
1. IANDOLO, J.J.
Genetic analyis of extracellular toxins of Staphylococcus aureus.
ANNU.REV.MICROBIOL. 43 375-402 (1989).
 
2. MARRACK, P. AND KAPPLER, J.
The Staphylococcal enterotoxins and their relatives.
SCIENCE 248 705-711 (1990).

Documentation
Staphylococcal enterotoxins and streptococcal pyrogenic exotoxins belong
to a family of related toxins [1,2] that share the ability to bind to
the major histocompatibility complex proteins of their hosts. A more
distant relative of the family is the Staphylococcus aureus toxic shock
syndrome toxin, which shares only a low level of sequence similarity
with this group. 
 
BACTRLTOXIN is a 2-element fingerprint that provides a signature for 
staphylococcal enterotoxins and streptococcal pyrogenic exotoxins. The
fingerprint was derived from an initial alignment of 7 sequences: the
motifs were drawn from the short conserved regions encoded by PROSITE
patterns STAPH_STREP_TOXIN_1 (PS00277) and STAPH_STREP_TOXIN_2 (PS00278).
Two iterations on OWL23.2 were required to reach convergence, at which
point a true set comprising 17 sequences was identified.
 
An update on SPTR37_9f identified a true set of 13 sequences.
Summary Information
13 codes involving  2 elements
Composite Feature Index
21313
12
True Positives
ETC1_STAAU    ETC2_STAAU    ETC3_STAAU    ETXA_STAAU    
ETXB_STAAU ETXD_STAAU ETXE_STAAU O85217
Q54738 Q54739 Q54971 SPEA_STRPY
SPEC_STRPY
Sequence Titles
ETC1_STAAU  Enterotoxin type C-1 precursor (SEC1) - Staphylococcus aureus. 
ETC2_STAAU Enterotoxin type C-2 precursor (SEC2) - Staphylococcus aureus.
ETC3_STAAU ENTEROTOXIN TYPE C-3 PRECURSOR (SEC3) - STAPHYLOCOCCUS AUREUS.
ETXA_STAAU ENTEROTOXIN TYPE A PRECURSOR (SEA) - STAPHYLOCOCCUS AUREUS.
ETXB_STAAU Enterotoxin type B precursor (SEB) - Staphylococcus aureus.
ETXD_STAAU Enterotoxin type D precursor (SED) - Staphylococcus aureus.
ETXE_STAAU Enterotoxin type E precursor (SEE) - Staphylococcus aureus.
O85217 Enterotoxin J - Staphylococcus aureus.
Q54738 Superantigen SSA - Streptococcus pyogenes.
Q54739 Superantigen SSA - Streptococcus pyogenes.
Q54971 Superantigen - Streptococcus pyogenes.
SPEA_STRPY Exotoxin type A precursor (Scarlet fever toxin) (Erythrogenic toxin) (SPE A) - Streptococcus pyogenes.
SPEC_STRPY Exotoxin type C precursor (SPE C) - Streptococcus pyogenes.
Scan History
OWL23_2    2  100  NSINGLE    
OWL26_0 1 100 NSINGLE
SPTR37_9f 2 100 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
CMYGGITKHEGNH ETC3_STAAU 137 137 -
CMYGGITKHEGNH ETC2_STAAU 137 137 -
CMYGGITKHEGNH ETC1_STAAU 137 137 -
CMYGGVTLHDNNR ETXA_STAAU 130 130 -
CMYGGVTLHDNNR ETXE_STAAU 130 130 -
CMYGGVTEHNGNQ ETXB_STAAU 140 140 -
CTYGGVTPHEGNK ETXD_STAAU 131 131 -

Motif 2 width=17
Element Seqn Id St Int Rpt
KKSVTAQELDIKARNFL ETC3_STAAU 178 28 -
KKSVTAQELDIKARNFL ETC2_STAAU 178 28 -
KKSVTAQELDIKARNFL ETC1_STAAU 178 28 -
KKNVTVQELDLQARRYL ETXA_STAAU 171 28 -
KKEVTVQELDLQARHYL ETXE_STAAU 171 28 -
KKKVTAQELDYLTRHYL ETXB_STAAU 179 26 -
KKNVTVQELDAQARRYL ETXD_STAAU 172 28 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
CMYGGVTEHHRNQ Q54971 134 134 -
CMYGGVTEHHRNQ Q54739 134 134 -
CMYGGVTEHHRNQ Q54738 134 134 -
CMYGGITKHEGNH ETC3_STAAU 137 137 -
CMYGGITKHEGNH ETC2_STAAU 137 137 -
CMYGGITKHEGNH ETC1_STAAU 137 137 -
CMYGGVTLHENNQ O85217 130 130 -
CMYGGVTLHDNNR ETXA_STAAU 130 130 -
CMYGGVTLHDNNR ETXE_STAAU 130 130 -
CMYGGVTEHNGNQ ETXB_STAAU 140 140 -
CIYGGVTNHEGNH SPEA_STRPY 128 128 -
CTYGGVTPHEGNK ETXD_STAAU 131 131 -
YIYGGITPAQNNK SPEC_STRPY 112 112 -

Motif 2 width=17
Element Seqn Id St Int Rpt
KKQVTVQELDCKTRKIL Q54971 174 27 -
KKQVTVQELDCKTRKIL Q54739 174 27 -
KKQVTVQELDCKTRKIL Q54738 174 27 -
KKSVTAQELDIKARNFL ETC3_STAAU 178 28 -
KKSVTAQELDIKARNFL ETC2_STAAU 178 28 -
KKSVTAQELDIKARNFL ETC1_STAAU 178 28 -
KKKVTIQELDLQARYYL O85217 171 28 -
KKNVTVQELDLQARRYL ETXA_STAAU 171 28 -
KKEVTVQELDLQARHYL ETXE_STAAU 171 28 -
KKKVTAQELDYLTRHYL ETXB_STAAU 179 26 -
KKMVTAQELDYKVRKYL SPEA_STRPY 167 26 -
KKNVTVQELDAQARRYL ETXD_STAAU 172 28 -
KDIVTFQEIDFKIRKYL SPEC_STRPY 151 26 -