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PR00278

Identifier
PANCHORMONE  [View Relations]  [View Alignment]  
Accession
PR00278
No. of Motifs
2
Creation Date
20-JAN-1994  (UPDATE 27-JUN-1999)
Title
Pancreatic hormone signature
Database References

PROSITE; PS00265 PANCREATIC_HORMONE
BLOCKS; BL00265
PFAM; PF00159 hormone3
INTERPRO; IPR001955
PDB; 1PPT
SCOP; 1PPT
Literature References
1. SCHWARTZ, T.W. AND HANSEN, H.F.
Isolation of ovine pancreatic icosapeptide - a peptide product containing
one cysteine residue.
FEBS LETT. 168(2) 293-298 (1984).
 
2. ALLEN, J., NOVOTNY, J., MARTIN, J. AND HEINRICH, G.
Molecular structure of mammalian neuropeptide Y - Analysis by molecular
cloning and computer-aided comparison with crystal structure of avian 
homolog.
PROC.NATL.ACAD.SCI.U.S.A. 84(8) 2532-2536 (1987).
 
3. SILLARD, R., AGERBERTH, B., MUTT, V. AND JORNVALL, H.
Sheep neuropeptide Y - A 3rd structural type of a highly conserved peptide.
FEBS LETT. 258(2) 263-265 (1989).
 
4. CONLON, J.M., BJENNING, C., MOON, T.W., YOUSON, J.H. AND THIM, L.
Neuropeptide Y-related peptides from the pancreas of a telostean (eel),
holostean (bowfin) and elasmobranch (skate) fish.
PEPTIDES 12(2) 221-226 (1991).

Documentation
The dominant endocrine cell type of the duodenal pancreas is the pancreatic
polypeptide cell, which secretes pancreatic polypeptide, a hormone involved
in the regulation of biliary tract motility, and of zymogen secretion from
the exocrine pancreas [1]. The hormone is produced as a larger propeptide,
which is enzymatically cleaved to yield the mature active peptide: this is
36 amino acids in length [2] and has an amidated C-terminus [3]. The
hormone has a globular structure, residues 2-8 forming a left-handed poly-
proline-II-like helix, residues 9-13 a beta turn, and 14-32 an alpha-helix,
held close to the first helix by hydrophobic interactions [2]. Unlike
glucagon, another peptide hormone, the structure of pancreatic peptide is
preserved in aqueous solution [4]. Both N- and C-termini are required for
activity: receptor binding and activation functions may reside in the N-
and C-termini respectively [2].
 
Further peptide hormones have been identified that are similar to 
pancreatic polypeptide in both sequence and structure, including neuro-
peptide tyrosine (often call neuropeptide Y) and peptide YY. Neuropeptide
Y, which is widely distributed in the central and peripheral nervous
systems, is implicated in the control of feeding, and secretion of gonado-
trophin-releasing hormone [2]. Peptide YY, a gut protein, inhibits exocrine
pancreatic secretion, can cause vasoconstriction, and affects jejunal and
colonic mobility [4].
 
PANCHORMONE is a 2-element fingerprint that provides a signature for the
pancreatic polypeptides. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs were drawn from the full alignment
length - motif 1 spans the polyproline-II-like helix, the beta turn and
part of the alpha-helix, and motif 2 includes the remaining portion of the
alpha-helix and the 5 conserved C-terminal residues encoded by PROSITE
pattern PANCREATIC_HORMONE (PS00265). Three iterations on OWL22.1 were
required to reach convergence, at which point a true set comprising 47
sequences was identified.
 
An update on SPTR37_9f identified a true set of 50 sequences.
Summary Information
50 codes involving  2 elements
Composite Feature Index
25050
12
True Positives
NEUY_CARAU    NEUY_CHICK    NEUY_GADMO    NEUY_HUMAN    
NEUY_ONCMY NEUY_PIG NEUY_RABIT NEUY_RANRI
NEUY_RAT NEUY_SHEEP NEUY_TORMA NEUY_XENLA
NPY_LAMFL PAHO_ALLMI PAHO_ANSAN PAHO_BOVIN
PAHO_CANFA PAHO_CAVPO PAHO_CERSI PAHO_CHIBR
PAHO_CHICK PAHO_DIDMA PAHO_EQUZE PAHO_ERIEU
PAHO_HUMAN PAHO_LARAR PAHO_MACMU PAHO_MOUSE
PAHO_PIG PAHO_RABIT PAHO_RANCA PAHO_RANTE
PAHO_RAT PAHO_STRCA PAHO_TAPPI PMY_PETMA
PYY_AMICA PYY_BOVIN PYY_CHICK PYY_HUMAN
PYY_LAMFL PYY_LEPSP PYY_MYOSC PYY_ONCKI
PYY_ORENI PYY_PIG PYY_RAJRH PYY_RANRI
PYY_RAT SPYY_PHYBI
Sequence Titles
NEUY_CARAU  NEUROPEPTIDE Y PRECURSOR (NPY) - CARASSIUS AURATUS (GOLDFISH). 
NEUY_CHICK NEUROPEPTIDE Y PRECURSOR (NPY) - GALLUS GALLUS (CHICKEN).
NEUY_GADMO NEUROPEPTIDE Y (NPY) - GADUS MORHUA (ATLANTIC COD).
NEUY_HUMAN NEUROPEPTIDE Y PRECURSOR (NPY) - HOMO SAPIENS (HUMAN).
NEUY_ONCMY NEUROPEPTIDE Y (NPY) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
NEUY_PIG NEUROPEPTIDE Y (NPY) - SUS SCROFA (PIG).
NEUY_RABIT NEUROPEPTIDE Y (NPY) - ORYCTOLAGUS CUNICULUS (RABBIT), CAVIA PORCELLUS (GUINEA PIG), AND ALLIGATOR MISSISSIPPIENSIS (AMERICAN ALLIGATOR).
NEUY_RANRI MELANOSTATIN (MELANOTROPIN-RELEASE-INHIBITING FACTOR) (NEUROPEPTIDE Y) (NPY) - RANA RIDIBUNDA (LAUGHING FROG) (MARSH FROG), AND RANA TEMPORARIA (EUROPEAN COMMON FROG).
NEUY_RAT NEUROPEPTIDE Y PRECURSOR (NPY) - RATTUS NORVEGICUS (RAT).
NEUY_SHEEP NEUROPEPTIDE Y (NPY) - OVIS ARIES (SHEEP).
NEUY_TORMA NEUROPEPTIDE Y PRECURSOR (NPY) - TORPEDO MARMORATA (MARBLED ELECTRIC RAY).
NEUY_XENLA NEUROPEPTIDE Y PRECURSOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
NPY_LAMFL NEUROPEPTIDE Y PRECURSOR (NPY) - LAMPETRA FLUVIATILIS (RIVER LAMPREY).
PAHO_ALLMI PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - ALLIGATOR MISSISSIPPIENSIS (AMERICAN ALLIGATOR).
PAHO_ANSAN PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - ANSER ANSER ANSER (WESTERN GRAYLAG GOOSE).
PAHO_BOVIN PANCREATIC HORMONE PRECURSOR (PANCREATIC POLYPEPTIDE) (PP) - BOS TAURUS (BOVINE).
PAHO_CANFA PANCREATIC HORMONE PRECURSOR (PANCREATIC POLYPEPTIDE) (PP) - CANIS FAMILIARIS (DOG).
PAHO_CAVPO PANCREATIC HORMONE PRECURSOR (PANCREATIC POLYPEPTIDE) (PP) - CAVIA PORCELLUS (GUINEA PIG).
PAHO_CERSI PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - CERATOTHERIUM SIMUM (WHITE RHINOCEROS) (SQUARE-LIPPED RHINOCEROS).
PAHO_CHIBR PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - CHINCHILLA BREVICAUDATA (CHINCHILLA).
PAHO_CHICK PANCREATIC HORMONE PRECURSOR (PANCREATIC POLYPEPTIDE) (PP) - GALLUS GALLUS (CHICKEN), AND MELEAGRIS GALLOPAVO (COMMON TURKEY).
PAHO_DIDMA PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - DIDELPHIS MARSUPIALIS VIRGINIANA (NORTH AMERICAN OPOSSUM).
PAHO_EQUZE PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - EQUUS ZEBRA (MOUNTAIN ZEBRA), AND EQUUS CABALLUS PRZEWALSKII (PRZEWALSKI'S HORSE).
PAHO_ERIEU PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - ERINACEUS EUROPAEUS (WESTERN EUROPEAN HEDGEHOG).
PAHO_HUMAN PANCREATIC HORMONE PRECURSOR (PANCREATIC POLYPEPTIDE) (PP) - HOMO SAPIENS (HUMAN).
PAHO_LARAR PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - LARUS ARGENTATUS (HERRING GULL).
PAHO_MACMU PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - MACACA MULATTA (RHESUS MACAQUE).
PAHO_MOUSE PANCREATIC HORMONE PRECURSOR (PANCREATIC POLYPEPTIDE) (PP) - MUS MUSCULUS (MOUSE).
PAHO_PIG PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - SUS SCROFA (PIG).
PAHO_RABIT PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - ORYCTOLAGUS CUNICULUS (RABBIT).
PAHO_RANCA PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - RANA CATESBEIANA (BULL FROG).
PAHO_RANTE PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - RANA TEMPORARIA (EUROPEAN COMMON FROG).
PAHO_RAT PANCREATIC HORMONE PRECURSOR (PANCREATIC POLYPEPTIDE) (PP) - RATTUS NORVEGICUS (RAT).
PAHO_STRCA PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - STRUTHIO CAMELUS (OSTRICH).
PAHO_TAPPI PANCREATIC HORMONE (PANCREATIC POLYPEPTIDE) (PP) - TAPIRUS PINCHAQUE (MOUNTAIN TAPIR).
PMY_PETMA PANCREATIC POLYPEPTIDE MY (PMY) - PETROMYZON MARINUS (SEA LAMPREY).
PYY_AMICA PEPTIDE YY-LIKE (PYY) - AMIA CALVA (BOWFIN).
PYY_BOVIN PEPTIDE YY PRECURSOR (PYY) - BOS TAURUS (BOVINE).
PYY_CHICK PEPTIDE YY-LIKE (PYY) - GALLUS GALLUS (CHICKEN).
PYY_HUMAN PEPTIDE YY PRECURSOR (PYY) - HOMO SAPIENS (HUMAN).
PYY_LAMFL PEPTIDE YY HOMOLOG PRECURSOR (PYY) - LAMPETRA FLUVIATILIS (RIVER LAMPREY).
PYY_LEPSP PEPTIDE YY-LIKE (PYY) (NEUROPEPTIDE Y-RELATED PEPTIDE) - LEPISOSTEUS SPATULA (ALLIGATOR GAR) (ATRACTOSTEUS SPATULA), SCYLIORHINUS CANICULA (SPOTTED DOGFISH) (SPOTTED CATSHARK), AND SQUALUS ACANTHIAS (SPINY DOGFISH).
PYY_MYOSC PEPTIDE YY-LIKE (PYY) - MYOXOCEPHALUS SCORPIUS (SHORTHORN SCULPIN) (DADDY SCULPIN).
PYY_ONCKI PEPTIDE YY-LIKE (PYY) - ONCORHYNCHUS KISUTCH (COHO SALMON), AND ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
PYY_ORENI PEPTIDE YY-LIKE (PYY) - OREOCHROMIS NILOTICUS (NILE TILAPIA) (TILAPIA NILOTICA).
PYY_PIG PEPTIDE YY (PYY) - SUS SCROFA (PIG), AND CANIS FAMILIARIS (DOG).
PYY_RAJRH PEPTIDE YY-LIKE (PYY) - RAJA RHINA (SKATE).
PYY_RANRI PEPTIDE YY-LIKE (PYY) - RANA RIDIBUNDA (LAUGHING FROG) (MARSH FROG).
PYY_RAT PEPTIDE YY PRECURSOR (PYY) - RATTUS NORVEGICUS (RAT).
SPYY_PHYBI SKIN PEPTIDE TYROSINE-TYROSINE (SPYY) - PHYLLOMEDUSA BICOLOR (TWO-COLORED LEAF FROG).
Scan History
OWL22_1    3  100  NSINGLE    
OWL26_0 1 100 NSINGLE
SPTR37_9f 2 100 NSINGLE
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
PLEPVYPGDNATPEQMA PAHO_FELCA 2 2 -
PSQPTYPGDDAPVEDLI N_1PPT 2 2 -
PLEPVYPGDDATPQQMA PAHO_CAVPO 28 28 -
PSEPHHPGDQATQDQLA PAHO_RANTE 2 2 -
PLQPKYPGDGAPVEDLI PAHO_ALLMI 2 2 -

Motif 2 width=17
Element Seqn Id St Int Rpt
QYYSDLYQYITFVTRPR PAHO_RANTE 19 0 -
QFYDDLQQYLNVVTRPR PAHO_ALLMI 19 0 -
QYAAELRRYINMLTRPR PAHO_FELCA 19 0 -
RFYDNLQQYLNVVTRHR N_1PPT 19 0 -
QYAAEMRRYINMLTRPR PAHO_CAVPO 45 0 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
PPKPENPGEDAPPEELA PYY_LEPSP 2 2 -
PPKPENPGEDAPPEELA PYY_AMICA 2 2 -
PPKPENPGEDAPPEELA PYY_ONCKI 2 2 -
PSKPDNPGDDAPAEDLA NEUY_SHEEP 2 2 -
PPKPENPGDDAAPEELA PYY_RAJRH 2 2 -
PSKPDNPGEDAPAEDMA NEUY_HUMAN 30 30 -
PSKPDNPGEDAPAEDMA NEUY_RAT 31 31 -
PSKPDNPGEDAPAEDMA NEUY_RABIT 2 2 -
PSKPDNPGEDAPAEDLA NEUY_PIG 2 2 -
PSKPDNPGEDAPAEDMA NEUY_XENLA 30 30 -
PSKPDNPGEDAPAEDMA NEUY_RANRI 2 2 -
PSKPDSPGEDAPAEDMA NEUY_CHICK 30 30 -
PSKPDNPGEGAPAEDLA NEUY_TORMA 30 30 -
PVKPENPGEDAPTEELA NEUY_ONCMY 2 2 -
PTKPDNPGEGAPAEELA NEUY_CARAU 30 30 -
PIKPENPGEDAPADELA NEUY_GADMO 2 2 -
PLEPVYPGDDATPEQMA PAHO_PIG 2 2 -
PLEPVYPGDDATPEQMA PAHO_CANFA 31 31 -
PPKPDNPGDNASPEQMA PYY_LAMFL 29 29 -
PPKPENPGEDASPEEMT PYY_RANRI 2 2 -
PLEPEYPGDNATPEQMA PAHO_BOVIN 31 31 -
PLEPVYPGDNATPEQMA PAHO_TAPPI 2 2 -
PPKPESPGEDASPEEMN SPYY_PHYBI 2 2 -
PLEPVYPGDNATPEEMA PAHO_CERSI 2 2 -
PLEPVYPGDNATPEQMA PAHO_HUMAN 31 31 -
PLEPVYPGDNATPEQMA PAHO_MACMU 2 2 -
PQEPVYPGDDATPEQMA PAHO_DIDMA 2 2 -
PNKPDSPGEDAPAEDLA NPY_LAMFL 36 36 -
PPEPVYPGDDATPEQMA PAHO_RABIT 2 2 -
PPKPESPGDAASPEEIA PYY_CHICK 3 3 -
PMEPVYPGDNATPEQMA PAHO_EQUZE 2 2 -
PLEPVYPGDNATPEQMA PAHO_ERIEU 2 2 -
PAKPEAPGEDASPEELS PYY_PIG 2 2 -
PAKPEAPGEDASPEELS PYY_RAT 30 30 -
PIKPEAPGEDASPEELN PYY_HUMAN 30 30 -
PLEPVYPGDNATPEQMA PAHO_CHIBR 2 2 -
PLEPMYPGDYATPEQMA PAHO_MOUSE 31 31 -
PPKPESPGSDASPEDWA PYY_ORENI 2 2 -
PLEPVYPGDDATPQQMA PAHO_CAVPO 28 28 -
PPQPESPGGNASPEDWA PYY_MYOSC 2 2 -
PLEPMYPGDYATHEQRA PAHO_RAT 31 31 -
PPKPDNPSPDASPEELS PMY_PETMA 2 2 -
PAKPQAPGEHASPDELN PYY_BOVIN 30 30 -
PSEPHHPGDQATPDQLA PAHO_RANCA 2 2 -
PSQPTYPGDDAPVEDLI PAHO_CHICK 27 27 -
PSEPHHPGDQATQDQLA PAHO_RANTE 2 2 -
PVQPTYPGDDAPVEDLV PAHO_LARAR 2 2 -
PAQPTYPGDDAPVEDLV PAHO_STRCA 2 2 -
PLQPKYPGDGAPVEDLI PAHO_ALLMI 2 2 -
PSQPTYPGNDAPVEDLR PAHO_ANSAN 2 2 -

Motif 2 width=17
Element Seqn Id St Int Rpt
KYYSALRHYINLITRQR PYY_LEPSP 19 0 -
RYYTALRHYINLITRQR PYY_AMICA 19 0 -
KYYTALRHYINLITRQR PYY_ONCKI 19 0 -
RYYSALRHYINLITRQR NEUY_SHEEP 19 0 -
KYYSALRHYINLITRQR PYY_RAJRH 19 0 -
RYYSALRHYINLITRQR NEUY_HUMAN 47 0 -
RYYSALRHYINLITRQR NEUY_RAT 48 0 -
RYYSALRHYINLITRQR NEUY_RABIT 19 0 -
RYYSALRHYINLITRQR NEUY_PIG 19 0 -
KYYSALRHYINLITRQR NEUY_XENLA 47 0 -
KYYSALRHYINLITRQR NEUY_RANRI 19 0 -
RYYSALRHYINLITRQR NEUY_CHICK 47 0 -
KYYSALRHYINLITRQR NEUY_TORMA 47 0 -
KYYTALRHYINLITRQR NEUY_ONCMY 19 0 -
KYYSALRHYINLITRQR NEUY_CARAU 47 0 -
KYYSALRHYINLITRQR NEUY_GADMO 19 0 -
QYAAELRRYINMLTRPR PAHO_PIG 19 0 -
QYAAELRRYINMLTRPR PAHO_CANFA 48 0 -
RYKAAVRHYINLITRQR PYY_LAMFL 46 0 -
KYLTALRHYINLVTRQR PYY_RANRI 19 0 -
QYAAELRRYINMLTRPR PAHO_BOVIN 48 0 -
QYAAELRRYINMLTRPR PAHO_TAPPI 19 0 -
KYLTALRHYINLVTRQR SPYY_PHYBI 19 0 -
QYAAELRRYINMLTRPR PAHO_CERSI 19 0 -
QYAADLRRYINMLTRPR PAHO_HUMAN 48 0 -
QYAADLRRYINMLTRPR PAHO_MACMU 19 0 -
KYAAELRRYINRLTRPR PAHO_DIDMA 19 0 -
RYLSAVRHYINLITRQR NPY_LAMFL 53 0 -
EYVADLRRYINMLTRPR PAHO_RABIT 19 0 -
QYFSALRHYINLVTRQR PYY_CHICK 20 0 -
QYAAELRRYINMLTRPR PAHO_EQUZE 19 0 -
HYAAELRRYINMLTRPR PAHO_ERIEU 19 0 -
RYYASLRHYLNLVTRQR PYY_PIG 19 0 -
RYYASLRHYLNLVTRQR PYY_RAT 47 0 -
RYYASLRHYLNLVTRQR PYY_HUMAN 47 0 -
QYAAEMRRYINMLTRPR PAHO_CHIBR 19 0 -
QYETQLRRYINTLTRPR PAHO_MOUSE 48 0 -
KYHAAVRHYVNLITRQR PYY_ORENI 19 0 -
QYAAEMRRYINMLTRPR PAHO_CAVPO 45 0 -
KYHAAVRHYVNLITRQR PYY_MYOSC 19 0 -
QYETQLRRYINTLTRPR PAHO_RAT 48 0 -
KYMLAVRNYINLITRQR PMY_PETMA 19 0 -
RYYTSLRHYLNLVTRQR PYY_BOVIN 47 0 -
QYYSDLYQYITFITRPR PAHO_RANCA 19 0 -
RFYNDLQQYLNVVTRHR PAHO_CHICK 44 0 -
QYYSDLYQYITFVTRPR PAHO_RANTE 19 0 -
RFYNDLQQYLNVVTRHR PAHO_LARAR 19 0 -
RFYDNLQQYLNVVTRHR PAHO_STRCA 19 0 -
QFYDDLQQYLNVVTRPR PAHO_ALLMI 19 0 -
FYYDNLQQYRLNVFRHR PAHO_ANSAN 19 0 -