| Literature References | 1. MIYAMOTO, M., FUJITA, T., KIMURA, Y., MARUYAMA, M., HARADA, H.,
SUDO, Y., MIYATA, T. AND TANIGUCHI, T.
Regulated expression of a gene encoding a nuclear factor, IRF-1, that
specifically binds to IFN-beta gene regulatory elements.
CELL 54 903-913 (1988).
2. WEISZ, A., MARX, P., SHARF, R., APPELLA, E., DRIGGERS, P.H., OZATO, K.
AND LEVI, B.Z.
Human interferon consensus sequence binding protein is a negative
regulator of enhancer elements common to interferon-inducible genes.
J.BIOL.CHEM. 267 25589-25596 (1992).
HARADA, H., FUJITA, T., MIYAMOTO, M., KIMURA, Y., MARUYAMA, M., FURIA, A.,
MIYATA, T. AND TANIGUCHI, T.
Structurally similar but functionally distinct factors, IRF-1 and IRF-2,
bind to the same regulatory elements of IFN and IFN-inducible genes.
CELL 58 729-739 (1989).
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| Documentation | The expression of type I interferon genes (interferons alpha and beta) is
induced by many agents, including viral attack [1]. Induction is mediated
by the binding of interferon regulatory factor 1 (IRF-1) to a region known
as the interferon consensus sequence (ICS), located upstream of the
interferon genes [2]. Other factors may also bind to the ICS, including
IRF-2, which does not function as an activator, but rather suppresses the
function of IRF-1 under certain circumstances [3]. IRF proteins contain a
conserved N-terminal region of about 120 amino acids, which folds into a
structure that binds specifically to the ICS; the remaining parts of the
sequences vary depending on the precise function of the protein [2].
INTFRNREGFCT is a 4-element fingerprint that provides a signature for the
ICS-binding region of interferon regulatory factors. The fingerprint was
derived from an initial alignment of 5 sequences: the motifs were drawn
from conserved regions spanning virtually the full length of the binding
domain, motif 4 including the region encoded by PROSITE pattern IRF
(PS00601). Two iterations on OWL25.1 were required to reach convergence,
at which point a true set comprising 9 sequences was identified.
An update on SPTR37_9f identified a true set of 29 sequences.
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