| Literature References | 1. BURGESS, W.H. AND MACIAG, T.
The heparin-binding (fibroblast) growth factor family of proteins.
ANNU.REV.BIOCHEMISTRY 58 575-606 (1989).
2. ERIKSSON, A.E., COUSENS, L.S., WEAVER, L.H. AND MATTHEWS, B.W.
Three-dimensional structure of human basic fibroblast growth factor.
PROC.NATL.ACAD.SCI.U.S.A. 88 3441-3445 (1991).
3. GIMENEZ-GALLEGO, G., RODKEY, J., BENNETT, C., RIOS-CANDELORE, M.,
DISALVO, J. AND THOMAS, K.
Brain-derived acidic fibroblast growth factor: complete amino acid sequence
and homologies.
SCIENCE 230 1385-1388 (1985).
4. MURZIN, A.G., LESK, A.M. AND CHOTHIA, C.
Patterns of structure and sequence in the Kunitz inhibitors, interleukins-1
beta and 1 alpha and fibroblast growth factors.
J.MOL.BIOL. 223 531-543 (1992).
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| Documentation | The heparin-binding growth factor (HBGF) family consists of at least 7
related proteins (HBGF1 - HBGF7) that bind to 3 different receptors and
have a strong affinity for heparin. This family is a member of a super-
family that also contains the interleukin-1 proteins, Kunitz-type soybean
trypsin inhibitors (STI) and histactophilin. All have very similar
structures, but although the HBGF and interleukin-1 families share some
sequence similarity (about 25% [1]), they show none at all to the STIs.
HBGFs are involved in many different processes related to cell differen-
tiation and growth control [1]. HBGF1 and HBGF2 have similar effects: they
induce mesoderm formation in embryogenesis, and mediate wound repair,
angiogenesis and neural outgrowth; they also induce proliferation and
migration of fibroblasts, endothelial cells and astroglial cells. HBGF3
(int-2) and HBGF4 (hst/ks) are known oncogenes, from stomach tumours and
Kaposi sarcoma respectively. HBGF5 and HBGF6 are also oncogene products.
HBGF7, keratinocyte growth factor, is possibly the major paracrine
effector of normal epithelial cell proliferation.
The crystal structures of HBGF1 (also known as acidic fibroblast growth
factor, aFGF, and FGF1) and HBGF2 (also known as basic fibroblast growth
factor, bFGF, and FGF2) [2] have been solved, showing them to have the same
12-stranded beta-sheet structure as both interleukin-1 and the Kunitz-type
soybean trypsin inhibitors [4]; HBGF1 and interleukin-1 had been found to
be similar, and they were predicted to have similar structures [3]. The
beta-sheets are arranged in 3 similar lobes around a central axis, 6
strands forming an anti-parallel beta-barrel. Several regions of HBGF1 have
been implicated in receptor binding, notably beta-strands 1-3, and the
loop between strands 8 and 9. The loop between strands 10 and 11 is thought
to be involved in binding heparin.
HBGFFGF is a 4-element fingerprint that provides a signature for the
HBGF family. The fingerprint was derived from an initial alignment of 3
sequences, the motifs all being drawn from beta-sheet regions, which are
generally more conserved than the loops between them: motif 1 spans strands
1 and 2; motif 2 strands 4 and 5; motif 3 strands 6 and 7; and motif 4
strands 8 and 9. Motifs 1 and 4 were of particular interest, since these
encode the strands implicated in receptor binding. Three iterations on
OWL17.1 were required to reach convergence, at which point all known
members of the HBGF family were identified.
An update on SPTR37_9f identified a true set of 45 sequences, and 10
partial matches.
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| Sequence Titles | FGF1_BOVIN HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) (PROSTATROPIN) (ENDOTHELIAL CELL GROWTH FACTOR BETA AND ALPHA CHAINS) (ACIDIC EYE-DERIVED GROWTH FACTOR II) (EDGF II) - BOS TAURUS (BOVINE).
FGF1_CHICK HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) (ALPHA-ENDOTHELIAL CELL GROWTH FACTOR) - GALLUS GALLUS (CHICKEN).
FGF1_HUMAN HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) (BETA-ENDOTHELIAL CELL GROWTH FACTOR) (ECGF- BETA) - HOMO SAPIENS (HUMAN).
FGF1_MESAU HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
FGF1_MOUSE HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
FGF2_BOVIN HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) [CONTAINS: KIDNEY-DERIVED GROWTH FACTOR] - BOS TAURUS (BOVINE).
FGF2_CHICK HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) - GALLUS GALLUS (CHICKEN).
FGF2_HUMAN HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - HOMO SAPIENS (HUMAN).
FGF2_MONDO HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - MONODELPHIS DOMESTICA (SHORT-TAILED GREY OPOSSUM).
FGF2_MOUSE HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - MUS MUSCULUS (MOUSE).
FGF2_RAT HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - RATTUS NORVEGICUS (RAT).
FGF2_SHEEP HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - OVIS ARIES (SHEEP).
FGF2_XENLA HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGF3_BRARE FIBROBLAST GROWTH FACTOR-3 PRECURSOR (FGF-3) (HBGF-3) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
FGF3_CHICK FIBROBLAST GROWTH FACTOR-3 PRECURSOR (FGF-3) (HBGF-3) - GALLUS GALLUS (CHICKEN).
FGF3_HUMAN INT-2 PROTO-ONCOGENE PROTEIN PRECURSOR (FIBROBLAST GROWTH FACTOR-3) (FGF-3) (HBGF-3) - HOMO SAPIENS (HUMAN).
FGF3_MOUSE INT-2 PROTO-ONCOGENE PROTEIN PRECURSOR (FIBROBLAST GROWTH FACTOR-3) (FGF-3) (HBGF-3) - MUS MUSCULUS (MOUSE).
FGF3_XENLA FIBROBLAST GROWTH FACTOR-3 PRECURSOR (FGF-3) (HBGF-3) (INT-2) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGF4_BOVIN FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (HEPARIN SECRETORY TRANSFORMING PROTEIN) (HST) (HBGF-4) - BOS TAURUS (BOVINE).
FGF4_CHICK FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (HBGF-4) - GALLUS GALLUS (CHICKEN).
FGF4_HUMAN FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (HEPARIN SECRETORY TRANSFORMING PROTEIN) (HST-1) (HST) (TRANSFORMING PROTEIN KS3) (HBGF- 4) - HOMO SAPIENS (HUMAN).
FGF4_MOUSE FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (K-FIBROBLAST GROWTH FACTOR) (HBGF-4) - MUS MUSCULUS (MOUSE).
FGF5_HUMAN FIBROBLAST GROWTH FACTOR-5 PRECURSOR (FGF-5) (HBGF-5) - HOMO SAPIENS (HUMAN).
FGF5_MOUSE FIBROBLAST GROWTH FACTOR-5 PRECURSOR (FGF-5) (HBGF-5) - MUS MUSCULUS (MOUSE).
FGF5_RAT FIBROBLAST GROWTH FACTOR-5 PRECURSOR (FGF-5) (HBGF-5) - RATTUS NORVEGICUS (RAT).
FGF6_HUMAN FIBROBLAST GROWTH FACTOR-6 PRECURSOR (FGF-6) (HBGF-6) (HST-2) - HOMO SAPIENS (HUMAN).
FGF6_MOUSE FIBROBLAST GROWTH FACTOR-6 PRECURSOR (FGF-6) (HBGF-6) (HST-2) - MUS MUSCULUS (MOUSE).
FGF7_HUMAN KERATINOCYTE GROWTH FACTOR PRECURSOR (KGF) (FIBROBLAST GROWTH FACTOR- 7) (FGF-7) (HBGF-7) - HOMO SAPIENS (HUMAN).
FGF7_MOUSE KERATINOCYTE GROWTH FACTOR PRECURSOR (KGF) (FIBROBLAST GROWTH FACTOR- 7) (FGF-7) (HBGF-7) - MUS MUSCULUS (MOUSE).
FGF7_RAT KERATINOCYTE GROWTH FACTOR PRECURSOR (KGF) (FIBROBLAST GROWTH FACTOR- 7) (FGF-7) (HBGF-7) - RATTUS NORVEGICUS (RAT).
FGF7_SHEEP KERATINOCYTE GROWTH FACTOR PRECURSOR (KGF) (FIBROBLAST GROWTH FACTOR- 7) (FGF-7) (HBGF-7) - OVIS ARIES (SHEEP).
FGF9_HUMAN GLIA-ACTIVATING FACTOR PRECURSOR (GAF) (FIBROBLAST GROWTH FACTOR-9) (FGF-9) (HBGF-9) - HOMO SAPIENS (HUMAN).
FGF9_MOUSE GLIA-ACTIVATING FACTOR PRECURSOR (GAF) (FIBROBLAST GROWTH FACTOR-9) (FGF-9) (HBGF-9) - MUS MUSCULUS (MOUSE).
FGF9_RAT GLIA-ACTIVATING FACTOR PRECURSOR (GAF) (FIBROBLAST GROWTH FACTOR-9) (FGF-9) (HBGF-9) - RATTUS NORVEGICUS (RAT).
FGF9_XENLA GLIA-ACTIVATING FACTOR PRECURSOR (GAF) (FIBROBLAST GROWTH FACTOR-9) (FGF-9) (HBGF-9) (XFGF-9) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGFA_HUMAN FIBROBLAST GROWTH FACTOR-10 PRECURSOR (FGF-10) (KERATINOCYTE GROWTH FACTOR 2) - HOMO SAPIENS (HUMAN).
FGFA_MOUSE FIBROBLAST GROWTH FACTOR-10 PRECURSOR (FGF-10) - MUS MUSCULUS (MOUSE).
FGFA_RAT FIBROBLAST GROWTH FACTOR-10 PRECURSOR (FGF-10) - RATTUS NORVEGICUS (RAT).
FGFA_XENLA FIBROBLAST GROWTH FACTOR-4-I PRECURSOR (FGF-4-I) (HBGF-4-I) (EMBRYONIC FIBROBLAST GROWTH FACTOR I) (XEFGF-I) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGFB_XENLA FIBROBLAST GROWTH FACTOR-4-II PRECURSOR (FGF-4-II) (HBGF-4-II) (EMBRYONIC FIBROBLAST GROWTH FACTOR II) (XEFGF-II) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGFG_HUMAN FIBROBLAST GROWTH FACTOR-16 (FGF-16) - HOMO SAPIENS (HUMAN).
FGFG_RAT FIBROBLAST GROWTH FACTOR-16 (FGF-16) - RATTUS NORVEGICUS (RAT).
O42407 FIBROBLAST GROWTH FACTOR 10 - GALLUS GALLUS (CHICKEN).
P78443 21 KD BASIC FIBROBLAST GROWTH FACTOR (BFGF) - HOMO SAPIENS (HUMAN).
P79150 KERATINOCYTE GROWTH FACTOR - CANIS FAMILIARIS (DOG).
FGFD_HUMAN FIBROBLAST GROWTH FACTOR-13 (FGF-13) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 2) (FHF-2) - HOMO SAPIENS (HUMAN).
FGFD_MOUSE FIBROBLAST GROWTH FACTOR-13 (FGF-13) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 2) (FHF-2) - MUS MUSCULUS (MOUSE).
FGFE_HUMAN FIBROBLAST GROWTH FACTOR-14 (FGF-14) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 4) (FHF-4) - HOMO SAPIENS (HUMAN).
FGFE_MOUSE FIBROBLAST GROWTH FACTOR-14 (FGF-14) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 4) (FHF-4) - MUS MUSCULUS (MOUSE).
O60371 R33683_2 - HOMO SAPIENS (HUMAN).
O89096 FHF-4B - RATTUS NORVEGICUS (RAT), AND MUS MUSCULUS (MOUSE).
Q07659 HEPARIN-BINDING GROWTH FACTOR 2 (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - GALLUS GALLUS (CHICKEN).
FGFB_HUMAN FIBROBLAST GROWTH FACTOR-11 (FGF-11) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 3) (FHF-3) - HOMO SAPIENS (HUMAN).
FGFB_MOUSE FIBROBLAST GROWTH FACTOR-11 (FGF-11) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 3) (FHF-3) - MUS MUSCULUS (MOUSE).
FGFC_HUMAN FIBROBLAST GROWTH FACTOR-12 (FGF-12) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 1) (FHF-1) (MYOCYTE-ACTIVATING FACTOR) - HOMO SAPIENS (HUMAN), AND MUS MUSCULUS (MOUSE).
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