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PR00263

Identifier
HBGFFGF  [View Relations]  [View Alignment]  
Accession
PR00263
No. of Motifs
4
Creation Date
14-OCT-1992  (UPDATE 07-JUN-1999)
Title
Heparin binding growth factor family signature
Database References
PRINTS; PR00262 IL1HBGF
PROSITE; PS00247 HBGF_FGF
BLOCKS; BL00247
INTERPRO; IPR002209
PDB; 1BAS
SCOP; 1BAS
CATH; 1BAS
Literature References
1. BURGESS, W.H. AND MACIAG, T.  
The heparin-binding (fibroblast) growth factor family of proteins. 
ANNU.REV.BIOCHEMISTRY 58 575-606 (1989).
 
2. ERIKSSON, A.E., COUSENS, L.S., WEAVER, L.H. AND MATTHEWS, B.W. 
Three-dimensional structure of human basic fibroblast growth factor. 
PROC.NATL.ACAD.SCI.U.S.A. 88 3441-3445 (1991).
 
3. GIMENEZ-GALLEGO, G., RODKEY, J., BENNETT, C., RIOS-CANDELORE, M.,
DISALVO, J. AND THOMAS, K.  
Brain-derived acidic fibroblast growth factor: complete amino acid sequence
and homologies. 
SCIENCE 230 1385-1388 (1985).
 
4. MURZIN, A.G., LESK, A.M. AND CHOTHIA, C.  
Patterns of structure and sequence in the Kunitz inhibitors, interleukins-1
beta and 1 alpha and fibroblast growth factors. 
J.MOL.BIOL. 223 531-543 (1992).

Documentation
The heparin-binding growth factor (HBGF) family consists of at least 7
related proteins (HBGF1 - HBGF7) that bind to 3 different receptors and
have a strong affinity for heparin. This family is a member of a super-
family that also contains the interleukin-1 proteins, Kunitz-type soybean 
trypsin inhibitors (STI) and histactophilin. All have very similar 
structures, but although the HBGF and interleukin-1 families share some 
sequence similarity (about 25% [1]), they show none at all to the STIs.
 
HBGFs are involved in many different processes related to cell differen-
tiation and growth control [1]. HBGF1 and HBGF2 have similar effects: they 
induce mesoderm formation in embryogenesis, and mediate wound repair, 
angiogenesis and neural outgrowth; they also induce proliferation and 
migration of fibroblasts, endothelial cells and astroglial cells. HBGF3 
(int-2) and HBGF4 (hst/ks) are known oncogenes, from stomach tumours and 
Kaposi sarcoma respectively. HBGF5 and HBGF6 are also oncogene products. 
HBGF7, keratinocyte growth factor, is possibly the major paracrine
effector of normal epithelial cell proliferation.
 
The crystal structures of HBGF1 (also known as acidic fibroblast growth
factor, aFGF, and FGF1) and HBGF2 (also known as basic fibroblast growth
factor, bFGF, and FGF2) [2] have been solved, showing them to have the same
12-stranded beta-sheet structure as both interleukin-1 and the Kunitz-type
soybean trypsin inhibitors [4]; HBGF1 and interleukin-1 had been found to 
be similar, and they were predicted to have similar structures [3]. The 
beta-sheets are arranged in 3 similar lobes around a central axis, 6 
strands forming an anti-parallel beta-barrel. Several regions of HBGF1 have 
been implicated in receptor binding, notably beta-strands 1-3, and the 
loop between strands 8 and 9. The loop between strands 10 and 11 is thought
to be involved in binding heparin.  
 
HBGFFGF is a 4-element fingerprint that provides a signature for the
HBGF family. The fingerprint was derived from an initial alignment of 3
sequences, the motifs all being drawn from beta-sheet regions, which are
generally more conserved than the loops between them: motif 1 spans strands
1 and 2; motif 2 strands 4 and 5; motif 3 strands 6 and 7; and motif 4
strands 8 and 9. Motifs 1 and 4 were of particular interest, since these
encode the strands implicated in receptor binding. Three iterations on 
OWL17.1 were required to reach convergence, at which point all known
members of the HBGF family were identified. 
 
An update on SPTR37_9f identified a true set of 45 sequences, and 10
partial matches.
Summary Information
  45 codes involving  4 elements
7 codes involving 3 elements
3 codes involving 2 elements
Composite Feature Index
445454545
35277
20033
1234
True Positives
FGF1_BOVIN    FGF1_CHICK    FGF1_HUMAN    FGF1_MESAU    
FGF1_MOUSE FGF2_BOVIN FGF2_CHICK FGF2_HUMAN
FGF2_MONDO FGF2_MOUSE FGF2_RAT FGF2_SHEEP
FGF2_XENLA FGF3_BRARE FGF3_CHICK FGF3_HUMAN
FGF3_MOUSE FGF3_XENLA FGF4_BOVIN FGF4_CHICK
FGF4_HUMAN FGF4_MOUSE FGF5_HUMAN FGF5_MOUSE
FGF5_RAT FGF6_HUMAN FGF6_MOUSE FGF7_HUMAN
FGF7_MOUSE FGF7_RAT FGF7_SHEEP FGF9_HUMAN
FGF9_MOUSE FGF9_RAT FGF9_XENLA FGFA_HUMAN
FGFA_MOUSE FGFA_RAT FGFA_XENLA FGFB_XENLA
FGFG_HUMAN FGFG_RAT O42407 P78443
P79150
True Positive Partials
Codes involving 3 elements
FGFD_HUMAN FGFD_MOUSE FGFE_HUMAN FGFE_MOUSE
O60371 O89096 Q07659
Codes involving 2 elements
FGFB_HUMAN FGFB_MOUSE FGFC_HUMAN
Sequence Titles
FGF1_BOVIN  HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) (PROSTATROPIN) (ENDOTHELIAL CELL GROWTH FACTOR BETA AND ALPHA CHAINS) (ACIDIC EYE-DERIVED GROWTH FACTOR II) (EDGF II) - BOS TAURUS (BOVINE). 
FGF1_CHICK HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) (ALPHA-ENDOTHELIAL CELL GROWTH FACTOR) - GALLUS GALLUS (CHICKEN).
FGF1_HUMAN HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) (BETA-ENDOTHELIAL CELL GROWTH FACTOR) (ECGF- BETA) - HOMO SAPIENS (HUMAN).
FGF1_MESAU HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
FGF1_MOUSE HEPARIN-BINDING GROWTH FACTOR 1 PRECURSOR (HBGF-1) (ACIDIC FIBROBLAST GROWTH FACTOR) (AFGF) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
FGF2_BOVIN HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) [CONTAINS: KIDNEY-DERIVED GROWTH FACTOR] - BOS TAURUS (BOVINE).
FGF2_CHICK HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) - GALLUS GALLUS (CHICKEN).
FGF2_HUMAN HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - HOMO SAPIENS (HUMAN).
FGF2_MONDO HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - MONODELPHIS DOMESTICA (SHORT-TAILED GREY OPOSSUM).
FGF2_MOUSE HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - MUS MUSCULUS (MOUSE).
FGF2_RAT HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - RATTUS NORVEGICUS (RAT).
FGF2_SHEEP HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - OVIS ARIES (SHEEP).
FGF2_XENLA HEPARIN-BINDING GROWTH FACTOR 2 PRECURSOR (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGF3_BRARE FIBROBLAST GROWTH FACTOR-3 PRECURSOR (FGF-3) (HBGF-3) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
FGF3_CHICK FIBROBLAST GROWTH FACTOR-3 PRECURSOR (FGF-3) (HBGF-3) - GALLUS GALLUS (CHICKEN).
FGF3_HUMAN INT-2 PROTO-ONCOGENE PROTEIN PRECURSOR (FIBROBLAST GROWTH FACTOR-3) (FGF-3) (HBGF-3) - HOMO SAPIENS (HUMAN).
FGF3_MOUSE INT-2 PROTO-ONCOGENE PROTEIN PRECURSOR (FIBROBLAST GROWTH FACTOR-3) (FGF-3) (HBGF-3) - MUS MUSCULUS (MOUSE).
FGF3_XENLA FIBROBLAST GROWTH FACTOR-3 PRECURSOR (FGF-3) (HBGF-3) (INT-2) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGF4_BOVIN FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (HEPARIN SECRETORY TRANSFORMING PROTEIN) (HST) (HBGF-4) - BOS TAURUS (BOVINE).
FGF4_CHICK FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (HBGF-4) - GALLUS GALLUS (CHICKEN).
FGF4_HUMAN FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (HEPARIN SECRETORY TRANSFORMING PROTEIN) (HST-1) (HST) (TRANSFORMING PROTEIN KS3) (HBGF- 4) - HOMO SAPIENS (HUMAN).
FGF4_MOUSE FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (K-FIBROBLAST GROWTH FACTOR) (HBGF-4) - MUS MUSCULUS (MOUSE).
FGF5_HUMAN FIBROBLAST GROWTH FACTOR-5 PRECURSOR (FGF-5) (HBGF-5) - HOMO SAPIENS (HUMAN).
FGF5_MOUSE FIBROBLAST GROWTH FACTOR-5 PRECURSOR (FGF-5) (HBGF-5) - MUS MUSCULUS (MOUSE).
FGF5_RAT FIBROBLAST GROWTH FACTOR-5 PRECURSOR (FGF-5) (HBGF-5) - RATTUS NORVEGICUS (RAT).
FGF6_HUMAN FIBROBLAST GROWTH FACTOR-6 PRECURSOR (FGF-6) (HBGF-6) (HST-2) - HOMO SAPIENS (HUMAN).
FGF6_MOUSE FIBROBLAST GROWTH FACTOR-6 PRECURSOR (FGF-6) (HBGF-6) (HST-2) - MUS MUSCULUS (MOUSE).
FGF7_HUMAN KERATINOCYTE GROWTH FACTOR PRECURSOR (KGF) (FIBROBLAST GROWTH FACTOR- 7) (FGF-7) (HBGF-7) - HOMO SAPIENS (HUMAN).
FGF7_MOUSE KERATINOCYTE GROWTH FACTOR PRECURSOR (KGF) (FIBROBLAST GROWTH FACTOR- 7) (FGF-7) (HBGF-7) - MUS MUSCULUS (MOUSE).
FGF7_RAT KERATINOCYTE GROWTH FACTOR PRECURSOR (KGF) (FIBROBLAST GROWTH FACTOR- 7) (FGF-7) (HBGF-7) - RATTUS NORVEGICUS (RAT).
FGF7_SHEEP KERATINOCYTE GROWTH FACTOR PRECURSOR (KGF) (FIBROBLAST GROWTH FACTOR- 7) (FGF-7) (HBGF-7) - OVIS ARIES (SHEEP).
FGF9_HUMAN GLIA-ACTIVATING FACTOR PRECURSOR (GAF) (FIBROBLAST GROWTH FACTOR-9) (FGF-9) (HBGF-9) - HOMO SAPIENS (HUMAN).
FGF9_MOUSE GLIA-ACTIVATING FACTOR PRECURSOR (GAF) (FIBROBLAST GROWTH FACTOR-9) (FGF-9) (HBGF-9) - MUS MUSCULUS (MOUSE).
FGF9_RAT GLIA-ACTIVATING FACTOR PRECURSOR (GAF) (FIBROBLAST GROWTH FACTOR-9) (FGF-9) (HBGF-9) - RATTUS NORVEGICUS (RAT).
FGF9_XENLA GLIA-ACTIVATING FACTOR PRECURSOR (GAF) (FIBROBLAST GROWTH FACTOR-9) (FGF-9) (HBGF-9) (XFGF-9) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGFA_HUMAN FIBROBLAST GROWTH FACTOR-10 PRECURSOR (FGF-10) (KERATINOCYTE GROWTH FACTOR 2) - HOMO SAPIENS (HUMAN).
FGFA_MOUSE FIBROBLAST GROWTH FACTOR-10 PRECURSOR (FGF-10) - MUS MUSCULUS (MOUSE).
FGFA_RAT FIBROBLAST GROWTH FACTOR-10 PRECURSOR (FGF-10) - RATTUS NORVEGICUS (RAT).
FGFA_XENLA FIBROBLAST GROWTH FACTOR-4-I PRECURSOR (FGF-4-I) (HBGF-4-I) (EMBRYONIC FIBROBLAST GROWTH FACTOR I) (XEFGF-I) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGFB_XENLA FIBROBLAST GROWTH FACTOR-4-II PRECURSOR (FGF-4-II) (HBGF-4-II) (EMBRYONIC FIBROBLAST GROWTH FACTOR II) (XEFGF-II) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
FGFG_HUMAN FIBROBLAST GROWTH FACTOR-16 (FGF-16) - HOMO SAPIENS (HUMAN).
FGFG_RAT FIBROBLAST GROWTH FACTOR-16 (FGF-16) - RATTUS NORVEGICUS (RAT).
O42407 FIBROBLAST GROWTH FACTOR 10 - GALLUS GALLUS (CHICKEN).
P78443 21 KD BASIC FIBROBLAST GROWTH FACTOR (BFGF) - HOMO SAPIENS (HUMAN).
P79150 KERATINOCYTE GROWTH FACTOR - CANIS FAMILIARIS (DOG).

FGFD_HUMAN FIBROBLAST GROWTH FACTOR-13 (FGF-13) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 2) (FHF-2) - HOMO SAPIENS (HUMAN).
FGFD_MOUSE FIBROBLAST GROWTH FACTOR-13 (FGF-13) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 2) (FHF-2) - MUS MUSCULUS (MOUSE).
FGFE_HUMAN FIBROBLAST GROWTH FACTOR-14 (FGF-14) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 4) (FHF-4) - HOMO SAPIENS (HUMAN).
FGFE_MOUSE FIBROBLAST GROWTH FACTOR-14 (FGF-14) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 4) (FHF-4) - MUS MUSCULUS (MOUSE).
O60371 R33683_2 - HOMO SAPIENS (HUMAN).
O89096 FHF-4B - RATTUS NORVEGICUS (RAT), AND MUS MUSCULUS (MOUSE).
Q07659 HEPARIN-BINDING GROWTH FACTOR 2 (HBGF-2) (BASIC FIBROBLAST GROWTH FACTOR) (BFGF) (PROSTATROPIN) - GALLUS GALLUS (CHICKEN).

FGFB_HUMAN FIBROBLAST GROWTH FACTOR-11 (FGF-11) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 3) (FHF-3) - HOMO SAPIENS (HUMAN).
FGFB_MOUSE FIBROBLAST GROWTH FACTOR-11 (FGF-11) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 3) (FHF-3) - MUS MUSCULUS (MOUSE).
FGFC_HUMAN FIBROBLAST GROWTH FACTOR-12 (FGF-12) (FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 1) (FHF-1) (MYOCYTE-ACTIVATING FACTOR) - HOMO SAPIENS (HUMAN), AND MUS MUSCULUS (MOUSE).
Scan History
OWL17_1    3  100  NSINGLE    
OWL18_0 1 100 NSINGLE
OWL19_1 1 100 NSINGLE
OWL26_0 1 100 NSINGLE
SPTR37_9f 2 61 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
KLLYCSNGGHFLR HBG1_HUMAN 27 27 -
RKLYCATKYHLQL HBG3_HUMAN 46 46 -
RRLFCRTQWYLRI HBG7_HUMAN 67 67 -

Motif 2 width=15
Element Seqn Id St Int Rpt
LQLSAESVGEVYIKS HBG1_HUMAN 59 19 -
LEITAVEVGIVAIRG HBG3_HUMAN 76 17 -
MEIRTVAVGIVAIKG HBG7_HUMAN 98 18 -

Motif 3 width=13
Element Seqn Id St Int Rpt
YLAMDTDGLLYGS HBG1_HUMAN 79 5 -
YLAMNKRGRLYAS HBG3_HUMAN 96 5 -
YLAMNKEGKLYAK HBG7_HUMAN 118 5 -

Motif 4 width=20
Element Seqn Id St Int Rpt
NEECLFLERLEENHYNTYIS HBG1_HUMAN 95 3 -
SAECEFVERIHELGYNTYAS HBG3_HUMAN 112 3 -
NEDCNFKELILENHYNTYAS HBG7_HUMAN 134 3 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
KRLYCKNGGFFLR FGF2_MOUSE 29 29 -
KRLYCKNGGFFLR FGF2_RAT 29 29 -
KRLYCKNGGFFLR FGF2_BOVIN 30 30 -
KRLYCKNGGFFLR P78443 71 71 -
KRLYCKNGGFFLR FGF2_SHEEP 30 30 -
KRLYCKNGGFFLR FGF2_HUMAN 30 30 -
KRLYCKNGGFFLR FGF2_MONDO 31 31 -
KRLYCKNGGFFLR FGF2_CHICK 33 33 -
KRLYCKNGGFFLR FGF2_XENLA 30 30 -
RKLYCATKYHLQI FGF3_BRARE 64 64 -
RRLYCNVGIGFHI FGF4_CHICK 72 72 -
RKLYCATKYHLQL FGF3_MOUSE 46 46 -
RKLYCATKYHLQI FGF3_CHICK 47 47 -
KLLYCSNGGHFLR FGF1_MESAU 27 27 -
RRLYCNVGIGFHI FGFB_XENLA 70 70 -
RRLYCNVGIGFHI FGFA_XENLA 65 65 -
RRLYCNVGIGFHL FGF4_HUMAN 84 84 -
RKLYCATKYHLQI FGF3_XENLA 64 64 -
KLLYCSNGGHFLR FGF1_MOUSE 27 27 -
RQLYCRTGFHLEI FGF9_HUMAN 64 64 -
RQLYCRTGFHLEI FGF9_XENLA 65 65 -
RQLYCRTGFHLEI FGF9_RAT 64 64 -
RQLYCRTGFHLEI FGF9_MOUSE 64 64 -
RKLYCATKYHLQL FGF3_HUMAN 46 46 -
KLLYCSNGGHFLR FGF1_HUMAN 27 27 -
RRLYCNVGIGFHL FGF4_BOVIN 84 84 -
KLLYCSNGGHFLR FGF1_CHICK 27 27 -
RRLYCNVGIGFHL FGF6_HUMAN 86 86 -
RQLYCRTGFHLEI FGFG_HUMAN 63 63 -
GSLYCRVGIGFHL FGF5_HUMAN 89 89 -
GSLYCRVGIGFHL FGF5_RAT 87 87 -
GSLYCRVGIGFHL FGF5_MOUSE 87 87 -
KLLYCSNGGYFLR FGF1_BOVIN 27 27 -
RRLFCRTQWYLRI FGF7_HUMAN 67 67 -
RRLFCRTQWYLRI P79150 67 67 -
RRLFCRTQWYLRI FGF7_SHEEP 67 67 -
RRLFCRTQWYLRI FGF7_MOUSE 67 67 -
RRLYCNVGIGFHL FGF6_MOUSE 86 86 -
RQLYCRTGFHLEI FGFG_RAT 63 63 -
RRLYCNVGIGFHL FGF4_MOUSE 80 80 -
RRLFCRTQWYLRI FGF7_RAT 67 67 -
RRLFSFTKYFLTI FGFA_MOUSE 81 81 -
RKLFSFTKYFLKI FGFA_HUMAN 80 80 -
RKLFSFTKYFLKI FGFA_RAT 87 87 -
RKLYSYNKYFLKI O42407 84 84 -

Motif 2 width=15
Element Seqn Id St Int Rpt
LQLQAEERGVVSIKG FGF2_MOUSE 61 19 -
LQLQAEERGVVSIKG FGF2_RAT 61 19 -
LQLQAEERGVVSIKG FGF2_BOVIN 62 19 -
LQLQAEERGVVSIKG P78443 103 19 -
LQLQAEERGVVSIKG FGF2_SHEEP 62 19 -
LQLQAEERGVVSIKG FGF2_HUMAN 62 19 -
LQLQAEERGVVSIKG FGF2_MONDO 63 19 -
LQLQAEERGVVSIKG FGF2_CHICK 65 19 -
LQLQAVERGVVSIKG FGF2_XENLA 62 19 -
LEITAVDVGVVAIKG FGF3_BRARE 95 18 -
LEISPVERGVVSIFG FGF4_CHICK 104 19 -
LEITAVEVGVVAIKG FGF3_MOUSE 76 17 -
LEITAVDVGIVAIKG FGF3_CHICK 78 18 -
LQLSAESAGEVYIKG FGF1_MESAU 59 19 -
LEISPVEVGVVSLYG FGFB_XENLA 102 19 -
LELSPVEVGVVSLYG FGFA_XENLA 97 19 -
LELSPVERGVVSIFG FGF4_HUMAN 116 19 -
LEITAVDVGIVAIKG FGF3_XENLA 95 18 -
LQLSAESAGEVYIKG FGF1_MOUSE 59 19 -
LEFISIAVGLVSIRG FGF9_HUMAN 95 18 -
LEFISIAVGLVSIRG FGF9_XENLA 96 18 -
LEFISIAVGLVSIRG FGF9_RAT 95 18 -
LEFISIAVGLVSIRG FGF9_MOUSE 95 18 -
LEITAVEVGIVAIRG FGF3_HUMAN 76 17 -
LQLSAESVGEVYIKS FGF1_HUMAN 59 19 -
LELSPVERGVVSIFG FGF4_BOVIN 116 19 -
LQLSAEDVGEVYIKS FGF1_CHICK 59 19 -
LEISTVERGVVSLFG FGF6_HUMAN 118 19 -
LEFISLAVGLISIRG FGFG_HUMAN 94 18 -
LEIFAVSQGIVGIRG FGF5_HUMAN 121 19 -
LEIFAVSQGIVGIRG FGF5_RAT 119 19 -
LEIFAVSQGIVGIRG FGF5_MOUSE 119 19 -
LQLCAESIGEVYIKS FGF1_BOVIN 59 19 -
MEIRTVAVGIVAIKG FGF7_HUMAN 98 18 -
MEIRTVAVGIVAIKG P79150 98 18 -
MEIRTVAVGIVAIKG FGF7_SHEEP 98 18 -
MEIRTVAVGIVAIKG FGF7_MOUSE 98 18 -
LEISTVERGVVSLFG FGF6_MOUSE 118 19 -
LEFISLAVGLISIRG FGFG_RAT 94 18 -
LELSPVQRGVVSIFG FGF4_MOUSE 112 19 -
MEIMTVAVGIVAIKG FGF7_RAT 98 18 -
LEITSVEIGVVAVKA FGFA_MOUSE 112 18 -
LEITSVEIGVVAVKA FGFA_HUMAN 111 18 -
LEITSVEIGVVAVKA FGFA_RAT 118 18 -
LEITSVEIGVVAVKS O42407 115 18 -

Motif 3 width=13
Element Seqn Id St Int Rpt
YLAMKEDGRLLAS FGF2_MOUSE 81 5 -
YLAMKEDGRLLAS FGF2_RAT 81 5 -
YLAMKEDGRLLAS FGF2_BOVIN 82 5 -
YLAMKEDGRLLAS P78443 123 5 -
YLAMKEDGRLLAS FGF2_SHEEP 82 5 -
YLAMKEDGRLLAS FGF2_HUMAN 82 5 -
YLAMKEDGRLLAL FGF2_MONDO 83 5 -
FLAMKEDGRLLAL FGF2_CHICK 85 5 -
YLAMKEDGRLTSL FGF2_XENLA 82 5 -
YLAMNEKGRLYAS FGF3_BRARE 115 5 -
FVAMNSKGKLYGS FGF4_CHICK 124 5 -
YLAMNKRGRLYAS FGF3_MOUSE 96 5 -
YLAMNKRGRLYAS FGF3_CHICK 98 5 -
YLAMDTDGLLYGS FGF1_MESAU 79 5 -
FVAMNAKGKLYGS FGFB_XENLA 122 5 -
FVAMNAKGKLYGS FGFA_XENLA 117 5 -
FVAMSSKGKLYGS FGF4_HUMAN 136 5 -
YLAMNQRGRLYAS FGF3_XENLA 115 5 -
YLAMDTEGLLYGS FGF1_MOUSE 79 5 -
YLGMNEKGELYGS FGF9_HUMAN 115 5 -
YLGMNEKGELYGS FGF9_XENLA 116 5 -
YLGMNEKGELYGS FGF9_RAT 115 5 -
YLGMNEKGELYGS FGF9_MOUSE 115 5 -
YLAMNKRGRLYAS FGF3_HUMAN 96 5 -
YLAMDTDGLLYGS FGF1_HUMAN 79 5 -
FVAMSSRGRLYGS FGF4_BOVIN 136 5 -
YLAMDTNGLLYGS FGF1_CHICK 79 5 -
FVAMNSKGRLYAT FGF6_HUMAN 138 5 -
YLGMNERGELYGS FGFG_HUMAN 114 5 -
FLAMSKKGKLHAS FGF5_HUMAN 141 5 -
FLAMSKKGKLHAS FGF5_RAT 139 5 -
FLAMSKKGKLHAS FGF5_MOUSE 139 5 -
FLAMDTDGLLYGS FGF1_BOVIN 79 5 -
YLAMNKEGKLYAK FGF7_HUMAN 118 5 -
YLAMNKEGKLYAK P79150 118 5 -
YLAMNKEGKLYAK FGF7_SHEEP 118 5 -
YLAMNKEGKLYAK FGF7_MOUSE 118 5 -
FIAMNSKGRLYTT FGF6_MOUSE 138 5 -
YLGMNERGELFGS FGFG_RAT 114 5 -
FVAMSSRGKLFGV FGF4_MOUSE 132 5 -
YLAMNKQGELYAK FGF7_RAT 118 5 -
YLAMNKKGKLYGS FGFA_MOUSE 132 5 -
YLAMNKKGKLYGS FGFA_HUMAN 131 5 -
YLAMNKKGKLYGS FGFA_RAT 138 5 -
YLAMNKKGKVYGS O42407 135 5 -

Motif 4 width=20
Element Seqn Id St Int Rpt
TEECFFFERLESNNYNTYRS FGF2_MOUSE 97 3 -
TEECFFFERLESNNYNTYRS FGF2_RAT 97 3 -
TDECFFFERLESNNYNTYRS FGF2_BOVIN 98 3 -
TDECFFFERLESNNYNTYRS P78443 139 3 -
TDECFFFERLESNNYNTYRS FGF2_SHEEP 98 3 -
TDECFFFERLESNNYNTYRS FGF2_HUMAN 98 3 -
TEECFFFERLESNNYNTYRS FGF2_MONDO 99 3 -
TEECFFFERLESNNYNTYRS FGF2_CHICK 101 3 -
TDECFFFERLEANNYNTYRS FGF2_XENLA 98 3 -
NRECEFLERIHELGYNTYAS FGF3_BRARE 131 3 -
NDECKFKEILLPNNYNAYES FGF4_CHICK 140 3 -
NAECEFVERIHELGYNTYAS FGF3_MOUSE 112 3 -
NTECEFVERIHELGYNTYAS FGF3_CHICK 114 3 -
NEECLFLERLEENHYNTYTS FGF1_MESAU 95 3 -
NEECKFKETLLPNNYNAYES FGFB_XENLA 138 3 -
NEECKFKETLLPNNYNAYES FGFA_XENLA 133 3 -
TDECTFKEILLPNNYNAYES FGF4_HUMAN 152 3 -
NPECEFVERIHELGYNTYAS FGF3_XENLA 131 3 -
NEECLFLERLEENHYNTYTS FGF1_MOUSE 95 3 -
TQECVFREQFEENWYNTYSS FGF9_HUMAN 131 3 -
TQECVFREQFEENWYNTYSS FGF9_XENLA 132 3 -
TQECVFREQFEENWYNTYSS FGF9_RAT 131 3 -
TQECVFREQFEENWYNTYSS FGF9_MOUSE 131 3 -
SAECEFVERIHELGYNTYAS FGF3_HUMAN 112 3 -
NEECLFLERLEENHYNTYIS FGF1_HUMAN 95 3 -
TDECRFREILLPNNYNAYEC FGF4_BOVIN 152 3 -
GEECLFLERLEENHYNTYIS FGF1_CHICK 95 3 -
QEECKFRETLLPNNYNAYES FGF6_HUMAN 154 3 -
TRECVFREQFEENWYNTYAS FGFG_HUMAN 130 3 -
TDDCKFRERFQENSYNTYAS FGF5_HUMAN 157 3 -
TDDCKFRERFQENSYNTYAS FGF5_RAT 155 3 -
TDDCKFRERFQENSYNTYAS FGF5_MOUSE 155 3 -
NEECLFLERLEENHYNTYIS FGF1_BOVIN 95 3 -
NEDCNFKELILENHYNTYAS FGF7_HUMAN 134 3 -
NEDCNFKELILENHYNTYAS P79150 134 3 -
NEDCNFKELILENHYNTYAS FGF7_SHEEP 134 3 -
NEDCNFKELILENHYNTYAS FGF7_MOUSE 134 3 -
HDECKFRETLLPNNYNAYES FGF6_MOUSE 154 3 -
TRECVFREQFEENWYNTYAS FGFG_RAT 130 3 -
TDECKFKEILLPNNYNAYEA FGF4_MOUSE 148 3 -
NEDCNFKELILENHYNTSAS FGF7_RAT 134 3 -
NNDCKLKERIEENGYNTYAS FGFA_MOUSE 148 3 -
NNDCKLKERIEENGYNTYAS FGFA_HUMAN 147 3 -
NNDCKLKERIEENGYNTYAS FGFA_RAT 154 3 -
NSDCKLKERIEENGYNTYAS O42407 151 3 -