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PR00217

Identifier
POSTSYNAPTIC  [View Relations]  [View Alignment]  
Accession
PR00217
No. of Motifs
4
Creation Date
02-NOV-1994  (UPDATE 07-JUN-1999)
Title
43Kd postsynaptic protein signature
Database References

PROSITE; PS00405 43_KD_POSTSYNAPTIC
BLOCKS; BL00405
INTERPRO; IPR001237
Literature References
1. FROEHNER, S.C.
The role of the postsynaptic cytoskeleton in AChr organisation.
TRENDS NEUROSCIENCE 9 37-41 (1986).
 
2. FROEHNER, S.C.
Expression of RNA transcripts for the postsynaptic 43kDa protein in
innervated and denervated rat skeletal muscle.
FEBS LETT. 249 229-233 (1989).

Documentation
The 43Kd postsynaptic protein is a peripheral membrane protein thought
to be involved in the anchoring or stabilisation of the nicotinic
acetylcholine receptor at synaptic sites [1,2]: it is possible that it
links the receptor to the postsynaptic cytoskeleton through direct
association with actin or spectrin. The protein is highly-conserved
across species, regions in the N- and C-termini possibly being important
for interaction with components of the postsynaptic membrane. 
 
POSTSYNAPTIC is a 4-element fingerprint that provides a signature for
43 Kd postsynaptic proteins. The fingerprint was derived from an initial
alignment of 4 sequences: motifs 1 and 2 were drawn from conserved
N-terminal regions, and motifs 3 and 4 from the C-terminus - motif 1
includes the region encoded by PROSITE pattern 43_KD_POSTSYNAPTIC
(PS00405). A single iteration on OWL24.0 was required to reach convergence,
no further sequences being identified beyond the starting set.
 
An update on SPTR37_9f identified a true set of 4 sequences.
Summary Information
4 codes involving  4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
44444
30000
20000
1234
True Positives
O42393        PS43_HUMAN    PS43_MOUSE    PS43_TORCA    
Sequence Titles
O42393      RAPSYN - GALLUS GALLUS (CHICKEN).             
PS43_HUMAN 43 KD POSTSYNAPTIC PROTEIN (ACETYLCHOLINE RECEPTOR-ASSOCIATED 43 KD PROTEIN) (RAPSYN) - HOMO SAPIENS (HUMAN).
PS43_MOUSE 43 KD POSTSYNAPTIC PROTEIN (ACETYLCHOLINE RECEPTOR-ASSOCIATED 43 KD PROTEIN) (RAPSYN) - MUS MUSCULUS (MOUSE).
PS43_TORCA 43 KD POSTSYNAPTIC PROTEIN (ACETYLCHOLINE RECEPTOR-ASSOCIATED 43 KD PROTEIN) - TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY).
Scan History
OWL24_0    1  50   NSINGLE    
SPTR37_9f 2 5 NSINGLE
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
QDQTKQQIEKGLQLYQSN HSACRAP 3 3 -
QDQTKQQIEKGLQLYQSN MUSRAPSYN 3 3 -
QDQTKQQIEKGLQLYQSN PS43_MOUSE 2 2 -
QDQTKQQIEKGLQLYQAN PS43_TORCA 2 2 -

Motif 2 width=19
Element Seqn Id St Int Rpt
KALQVWMKVLEKGSDLVGR MUSRAPSYN 24 3 -
KALQVWMKVLEKGSDLVGR PS43_MOUSE 23 3 -
KALEIWQQVVERSTELPGR PS43_TORCA 23 3 -
KALQVWTKVLEKSSDLMGR HSACRAP 24 3 -

Motif 3 width=16
Element Seqn Id St Int Rpt
LQALPCSHIFHLRCLQ PS43_MOUSE 376 334 -
LQALPCSHIFHLRCLQ MUSRAPSYN 377 334 -
LQALPCSHLFHLKCLQ PS43_TORCA 376 334 -
LQALPCSHIFHLRCLQ HSACRAP 377 334 -

Motif 4 width=17
Element Seqn Id St Int Rpt
NGTRSCPNCRRSSMKPG MUSRAPSYN 394 1 -
NGNRGCPNCKRSSVKPG PS43_TORCA 393 1 -
NGTRSCPNCRRSSMKPG HSACRAP 394 1 -
NGTRSCPNCRRSSMKPG PS43_MOUSE 393 1 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
QDQTKQQIEKGLQLYQSN PS43_HUMAN 2 2 -
QDQTKQQIEKGLQLYQSN PS43_MOUSE 2 2 -
QDQTKQQIEKGLHLYQSN O42393 3 3 -
QDQTKQQIEKGLQLYQAN PS43_TORCA 2 2 -

Motif 2 width=19
Element Seqn Id St Int Rpt
KALQVWTKVLEKSSDLMGR PS43_HUMAN 23 3 -
KALQVWMKVLEKGSDLVGR PS43_MOUSE 23 3 -
KALQVWMRVLEKSADPAGR O42393 24 3 -
KALEIWQQVVERSTELPGR PS43_TORCA 23 3 -

Motif 3 width=16
Element Seqn Id St Int Rpt
LQALPCSHIFHLRCLQ PS43_HUMAN 376 334 -
LQALPCSHIFHLRCLQ PS43_MOUSE 376 334 -
LQALPCSHFFHLKCLQ O42393 377 334 -
LQALPCSHLFHLKCLQ PS43_TORCA 376 334 -

Motif 4 width=17
Element Seqn Id St Int Rpt
NGTRSCPNCRRSSMKPG PS43_HUMAN 393 1 -
NGTRSCPNCRRSSMKPG PS43_MOUSE 393 1 -
NGTRGCPNCRRLSVKPG O42393 394 1 -
NGNRGCPNCKRSSVKPG PS43_TORCA 393 1 -