Identifier | AMYLOIDA4  [View Relations]  [View Alignment]  
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Accession | PR00203 |
No. of Motifs | 4 |
Creation Date | 14-SEP-1993  (UPDATE 06-JUN-1999) |
Title | Amyloid A4 protein precursor signature |
Database References | PRINTS; PR00204 BETAAMYLOID PROSITE; PS00319 A4_EXTRA; PS00320 A4_INTRA; PS00280 BPTI_KUNITZ
BLOCKS; BL00319 INTERPRO; IPR001868 PDB; 1AAP SCOP; 1AAP CATH; 1AAP |
Literature References | 1. HARDY, J.
Framing beta-amyloid.
NATURE GENET.(1) 233-234 (1992).
2. ARISPE, N., ROJAS, E. AND POLLARD, H.B.
Alzheimers disease amyloid beta-protein forms calcium channels in bilayer
membranes: blockade by tromethamine and aluminum.
PROC.NATL.ACAD.SCI.U.S.A. 90 567-571 (1993).
3. OTVOS, L., SZENDREI, G.I., LEE, V.M.-Y AND MANTSCH, H.H.
Human and rodent Alzheimer beta-amyloid peptides acquire distinct
conformations in membrane-mimicking solvents.
EUR.J.BIOCHEMISTRY 211 249-257 (1993).
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Documentation | Amyloid A4 protein precursor (APP) is an integral, glycosylated membrane
brain protein. APP contains a 40-residue peptide, known as beta-amyloid
protein (beta-APP), which forms the major constituent of the amyloid
deposits that characterise Alzheimers disease and aged Down's Syndrome. The
exact function of APP is unknown, but it may mediate cell-cell inter-
actions. The protein comprises a large extracellular N-terminal domain,
and a short hydrophobic membrane-spanning domain, followed by a short
C-terminal region - the beta amyloid protein both precedes and forms
part of the transmembrane domain [1-3].
AMYLOIDA4 is a 4-element fingerprint that provides a signature for the
amyloid A4 protein precursor. The fingerprint was derived from an initial
alignment of 3 sequences: motif 1 includes the extracellular region encoded
by PROSITE pattern A4_EXTRA (PS00319); motif 3 corresponds to the trans-
membrane domain; and motif 4 includes the cytoplasmic region encoded by
PROSITE pattern A4_INTRA (PS00320). Two iterations on OWL21.1 were required
to reach convergence, at which point a true set comprising 10 sequences was
identified. Six partial matches were also found, most of which are
fragments: YWK2_RAT is a sperm membrane protein known to share a high
degree of similarity with the A4 amyloid protein towards its C-terminus.
An update on SPTR37_9f identified a true set of 18 sequences, and 3
partial matches.
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Summary Information | 18 codes involving 4 elements 1 codes involving 3 elements 2 codes involving 2 elements
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Composite Feature Index | |
True Positives | A4_HUMAN A4_MOUSE A4_RAT A4_SAISC APP1_HUMAN APP1_MOUSE APP2_HUMAN APP2_MOUSE APP2_RAT O57394 O73683 O93279 P97487 Q60496 Q60709 Q61482 Q64348 Q91963 |
True Positive Partials | |
Sequence Titles | A4_HUMAN ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN PRECURSOR (PROTEASE NEXIN-II) (PN-II) (APPI) [CONTAINS: BETA-AMYLOID PROTEIN (BETA-APP)] - HOMO SAPIENS (HUMAN). A4_MOUSE ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN HOMOLOG PRECURSOR (AMYLOIDOGENIC GLYCOPROTEIN) (AG) - MUS MUSCULUS (MOUSE). A4_RAT ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN HOMOLOG PRECURSOR (AMYLOIDOGENIC GLYCOPROTEIN) (AG) - RATTUS NORVEGICUS (RAT). A4_SAISC ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN PRECURSOR [CONTAINS: BETA- AMYLOID PROTEIN (BETA-APP)] - SAIMIRI SCIUREUS (COMMON SQUIRREL MONKEY). APP1_HUMAN AMYLOID-LIKE PROTEIN 1 PRECURSOR (APLP) - HOMO SAPIENS (HUMAN). APP1_MOUSE AMYLOID-LIKE PROTEIN 1 PRECURSOR (APLP) - MUS MUSCULUS (MOUSE). APP2_HUMAN AMYLOID-LIKE PROTEIN 2 PRECURSOR (AMYLOID PROTEIN HOMOLOG) (APPH) (CDEI-BOX BINDING PROTEIN) (CDEBP) - HOMO SAPIENS (HUMAN). APP2_MOUSE AMYLOID-LIKE PROTEIN 2 PRECURSOR (CDEI-BOX BINDING PROTEIN) (CDEBP) - MUS MUSCULUS (MOUSE). APP2_RAT AMYLOID-LIKE PROTEIN 2 PRECURSOR (SPERM MEMBRANE PROTEIN YWK-II) - RATTUS NORVEGICUS (RAT). O57394 EL AMYLOID PRECURSOR PROTEIN 699 - NARKE JAPONICA (ELECTRIC RAY). O73683 AMYLOID PRECURSOR PROTEIN - TETRAODON FLUVIATILIS (PUFFER FISH). O93279 BETA-AMYLOID PRECURSOR PROTEIN - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES). P97487 HIPPOCAMPAL AMYLOID PROTEIN - MUS MUSCULUS (MOUSE). Q60496 ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN - CAVIA PORCELLUS (GUINEA PIG). Q60709 AMYLOID BETA (A4) PRECURSOR-LIKE PROTEIN 2 (AMYLOID-LIKE PROTEIN 2, ISOFORM 751) - MUS MUSCULUS (MOUSE). Q61482 CDE1-BINDING PROTEIN - MUS MUSCULUS (MOUSE). Q64348 AMYLOID BETA (A4) PRECURSOR-LIKE PROTEIN 2 (HYPOTHETICAL 79.0 KD PROTEIN) - MUS MUSCULUS (MOUSE). Q91963 APP747 - XENOPUS LAEVIS (AFRICAN CLAWED FROG). Q10651 BETA-AMYLOID-LIKE PROTEIN PRECURSOR - CAENORHABDITIS ELEGANS. A4_DROME BETA-AMYLOID-LIKE PROTEIN PRECURSOR - DROSOPHILA MELANOGASTER (FRUIT FLY). Q13764 AMYLOID-BETA PROTEIN - HOMO SAPIENS (HUMAN).
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Scan History | OWL21_1 2 50 NSINGLE OWL25_2 1 50 NSINGLE SPTR37_9f 2 190 NSINGLE
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Initial Motifs | Motif 1 width=19 Element Seqn Id St Int Rpt DKFRGVEFVCCPLAEESDS A4_MOUSE 176 176 - DKFRGVEFVCCPLAEESDS A4_RAT 176 176 - DKFRGVEFVCCPLAEESDN A4_HUMAN 176 176 - Motif 2 width=24 Element Seqn Id St Int Rpt PGDENEHAHFQKAKERLEAKHRER A4_MOUSE 381 186 - PGDENEHAHFQKAKERLEAKHRER A4_RAT 381 186 - PGDENEHAHFQKAKERLEAKHRER A4_HUMAN 381 186 - Motif 3 width=26 Element Seqn Id St Int Rpt KGAIIGLMVGGVVIATVIVITLVMLK A4_MOUSE 698 293 - KGAIIGLMVGGVVIATVIVITLVMLK A4_RAT 698 293 - KGAIIGLMVGGVVIATVIVITLVMLK A4_HUMAN 698 293 - Motif 4 width=23 Element Seqn Id St Int Rpt EERHLSKMQQNGYENPTYKFFEQ A4_MOUSE 744 20 - EERHLSKMQQNGYENPTYKFFEQ A4_RAT 744 20 - EERHLSKMQQNGYENPTYKFFEQ A4_HUMAN 744 20 -
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Final Motifs | Motif 1 width=19 Element Seqn Id St Int Rpt DKFRGVEFVCCPLAEESDS A4_MOUSE 176 176 - DKFRGVEFVCCPLAEESDS P97487 177 177 - DKFRGVEFVCCPLAEESDS A4_RAT 176 176 - DKFRGVEFVCCPLAEESDN A4_HUMAN 176 176 - DKFRGVEFVCCPLAEESDN Q60496 177 177 - DKFRGVEFVCCPLAEESDH A4_SAISC 177 177 - DEFRGVEFVCCPIPEENDK O57394 189 189 - DRFRGVEFVCCPAEAERDM O73683 178 178 - DKFRGVEFVCCPSAEESES Q91963 173 173 - DQFHGTEYVCCPQTKTVDS APP2_MOUSE 193 193 - DQFHGTEYVCCPQTKTVDS Q64348 193 193 - DQFHGTEYVCCPQTKTVDS Q61482 193 193 - DQFHGTEYVCCPQTKTVDS Q60709 193 193 - DQFHGTEYVCCPQTKVVDS APP2_RAT 193 193 - DQFHGTEYVCCPQTKIIGS APP2_HUMAN 193 193 - DRFRGVKFVCCPAETEQET O93279 178 178 - DRFRGVEYVCCPPPATPNP APP1_MOUSE 199 199 - DRFRGVEYVCCPPPGTPDP APP1_HUMAN 200 200 - Motif 2 width=24 Element Seqn Id St Int Rpt PGDENEHAHFQKAKERLEAKHRER A4_MOUSE 381 186 - PGDENEHAHFQKAKERLEAKHRER P97487 307 111 - PGDENEHAHFQKAKERLEAKHRER A4_RAT 381 186 - PGDENEHAHFQKAKERLEAKHRER A4_HUMAN 381 186 - PGDENEHAHFQKAKERLEAKHRER Q60496 307 111 - PGDENEHAHFQKAKERLEAKHRER A4_SAISC 363 167 - PGDENEHAYFQKAKERLEAKHRER O57394 311 103 - PADENEHAHFQKAKESLEAKHRER O73683 400 203 - PNDENEHDRFLKAKERLEGKHREK Q91963 359 167 - SADDNEHARFQKAKEQLEIRHRNR APP2_MOUSE 325 113 - SADDNEHARFQKAKEQLEIRHRNR Q64348 325 113 - SADDNEHARFQKAKEQLEIRHRNR Q61482 381 169 - SADDNEHARFQKAKEQLEIRHRNR Q60709 381 169 - SADDNEHARFQKAKEQLEIRHRSR APP2_RAT 383 171 - SADDNEHARFQKAKEQLEIRHRNR APP2_HUMAN 381 169 - PGDDNEHADFRKAKESLEAKHRER O93279 362 165 - PGEIGEHEGFLRAKMDLEERRMRQ APP1_MOUSE 304 86 - PGEISEHEGFLRAKMDLEERRMRQ APP1_HUMAN 301 82 - Motif 3 width=26 Element Seqn Id St Int Rpt KGAIIGLMVGGVVIATVIVITLVMLK A4_MOUSE 698 293 - KGAIIGLMVGGVVIATVIVITLVMLK P97487 624 293 - KGAIIGLMVGGVVIATVIVITLVMLK A4_RAT 698 293 - KGAIIGLMVGGVVIATVIVITLVMLK A4_HUMAN 698 293 - KGAIIGLMVGGVVIATVIVITLVMLK Q60496 624 293 - KGAIIGLMVGGVVIATVIVITLVMLK A4_SAISC 680 293 - KGAIIGLMVGGVVIATVIVITLVMLK O57394 628 293 - KGAIIGLMVGGVVIATVIVITLVMLR O73683 709 285 - KGAIIGLMVGGVVIATVIVITLVMLK Q91963 676 293 - SNALIGLLVIAVAIATVIVISLVMLR APP2_MOUSE 624 275 - SNALIGLLVIAVAIATVIVISLVMLR Q64348 624 275 - SNALIGLLVIAVAIATVIVISLVMLR Q61482 692 287 - SNALIGLLVIAVAIATVIVISLVMLR Q60709 680 275 - SSALIGLLVIAVAIATVIVISLVMLR APP2_RAT 694 287 - SSALIGLLVIAVAIATVIVISLVMLR APP2_HUMAN 692 287 - KGAIIGLMVGGVVIATVIVITLVMLR O93279 666 280 - REALSGLLIMGAGGGSLIVLSLLLLR APP1_MOUSE 582 254 - REAVSGLLIMGAGGGSLIVLSMLLLR APP1_HUMAN 579 254 - Motif 4 width=23 Element Seqn Id St Int Rpt EERHLSKMQQNGYENPTYKFFEQ A4_MOUSE 744 20 - EERHLSKMQQNGYENPTYKFFEQ P97487 670 20 - EERHLSKMQQNGYENPTYKFFEQ A4_RAT 744 20 - EERHLSKMQQNGYENPTYKFFEQ A4_HUMAN 744 20 - EERHLSKMQQNGYENPTYKFFEQ Q60496 670 20 - EERHLSKMQQNGYENPTYKFFEQ A4_SAISC 726 20 - EERHLSKMQQNGYENPTYKFFEQ O57394 674 20 - EERHLSKMQQNGYENPTYKFFEQ O73683 755 20 - EERHLTKMQQNGYENPTYKFFEQ Q91963 722 20 - EERHLNKMQNHGYENPTYKYLEQ APP2_MOUSE 670 20 - EERHLNKMQNHGYENPTYKYLEQ Q64348 670 20 - EERHLNKMQNHGYENPTYKYLEQ Q61482 738 20 - EERHLNKMQNHGYENPTYKYLEQ Q60709 726 20 - EERHLNKMQNHGYENPTYKYLEQ APP2_RAT 740 20 - EERHLNKMQNHGYENPTYKYLEQ APP2_HUMAN 738 20 - EERHLARMQQNGYENPTYKFFEQ O93279 712 20 - EEQQLRELQRHGYENPTYRFLEE APP1_MOUSE 629 21 - EEQQLRELQRHGYENPTYRFLEE APP1_HUMAN 626 21 -
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