| Literature References | 1. JAP, B.K. AND WALIAN, P.J.
Biophysics of the structure and function of porins.
Q.REV.BIOPHYS. 23 367-403 (1990).
2. NIKAIDO, H.
Porins and specific channels of bacterial outer membranes.
MOL.MICROBIOL. 6 435-442 (1992).
3. WEISS, M.S., KREUSCH, A., SCHILTZ, E., NESTEL, U., WELTE, W.,
WECKESSER, J. AND SCHULZ, G.E.
The structure of porin from Rhodobacter casulatus at 1.8A resolution.
FEBS LETT. 280 379-382 (1991).
4. PAUPTIT, R.A., SCHIRMER, T., JANSONIUS, J.N., ROSENBUSCH, J.P,
PARKER, M.W., TUCKER, A.D., TSERNOGLOU, D., WIESS, M.S. AND SCHULZ, G.E.
A common channel-forming motif in evolutionarily distant porins
J.STRUCT.BIOL. 107 136-145 (1991).
5. KREUSCH, A. AND SCHULZ, G.E.
Refined structure of the porin from Rhodopseudomonas blastica.
Comparison with the porin from Rhodobacter capsulatus.
J.MOL.BIOL. 243 891-905 (1994).
6. COWAN, S.W.
Bacterial porins: lessons from three high-resolution structures.
CURR.OPIN.STRUCT.BIOL. 3 501-507 (1993).
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| Documentation | Porins are found in the outer membranes of Gram-negative bacteria,
mitochondria and chloroplasts, where they form ion-selective channels for
small hydrophilic molecules (up to ~600 Da) [1,2]. X-ray structure analyses
of several bacterial porins [3-5] have revealed a 16-stranded anti-parallel
beta-barrel structure enclosing the transmembrane pore, by contrast with
all other integral membrane proteins described to date, which are alpha-
helical. Three subunits form a trimer; the 3-fold axis is approximately
parallel to the barrel axes and is assumed to be perpendicular to the
membrane plane [6].
From the range of porins now known, similarities have been observed between
porins from different species, and between porins of different specificity
within the same species. But most porins cannot be related to each other on
the basis of sequence alone, and this is reflected in the lengths of the
known porin sequences, which range from 282-483 residues/monomer.
ECOLNEIPORIN is a 5-element fingerprint that provides a signature for both
Neisseria and E.coli/Salmonella-type porins. The fingerprint was derived
from an initial alignment of 8 sequences: the motifs were drawn from
conserved regions spanning virtually the full alignment length. Three
iterations on OWL19.1 were required to reach convergence, at which point
a true set comprising 51 sequences was identified. The fingerprint is
selective for this superfamily, and there is no cross-reaction with
eukaryotic porins.
An update on SPTR37_9f identified a true set of 83 sequences, and 1
partial match.
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| Sequence Titles | NMPC_ECOLI OUTER MEMBRANE PORIN PROTEIN NMPC PRECURSOR - ESCHERICHIA COLI.
O08266 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
O51943 HYBRID OUTER MEMBRANE PROTEIN IA/IB PRECURSOR - NEISSERIA GONORRHOEAE.
O51944 OUTER MEMBRANE PROTEIN I PRECURSOR - NEISSERIA GONORRHOEAE.
O51945 OUTER MEMBRANE PROTEIN I PRECURSOR - NEISSERIA GONORRHOEAE.
O51946 OUTER MEMBRANE PROTEIN I PRECURSOR - NEISSERIA GONORRHOEAE.
O51947 OUTER MEMBRANE PROTEIN I PRECURSOR - NEISSERIA GONORRHOEAE.
O51948 OUTER MEMBRANE PROTEIN I PRECURSOR - NEISSERIA GONORRHOEAE.
O52693 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O52694 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O52695 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O52696 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O52697 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O52698 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O52699 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O52700 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O52701 OUTER MEMBRANE PORIN - NEISSERIA GONORRHOEAE.
O85030 PORIN OMPN - ESCHERICHIA COLI.
O87753 OMPK35 PORIN PRECURSOR - KLEBSIELLA PNEUMONIAE.
O87754 OMPK37 PORIN PRECURSOR - KLEBSIELLA PNEUMONIAE.
OMA1_NEIGO MAJOR OUTER MEMBRANE PROTEIN PI.A PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA GONORRHOEAE.
OMA1_NEIME MAJOR OUTER MEMBRANE PROTEIN PI.A PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA MENINGITIDIS.
OMA2_NEIME MAJOR OUTER MEMBRANE PROTEIN P.IA PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA MENINGITIDIS.
OMB1_NEIGO MAJOR OUTER MEMBRANE PROTEIN P.IB PRECURSOR (PROTEIN IB) (PIB) (PORIN) - NEISSERIA GONORRHOEAE.
OMB1_NEIME MAJOR OUTER MEMBRANE PROTEIN P.IB PRECURSOR (PROTEIN IB) (PIB) (PORIN) (CLASS 3) - NEISSERIA MENINGITIDIS.
OMB2_NEIGO MAJOR OUTER MEMBRANE PROTEIN P.IB PRECURSOR (PROTEIN IB) (PIB) (PORIN) - NEISSERIA GONORRHOEAE.
OMB2_NEIME MAJOR OUTER MEMBRANE PROTEIN P.IB PRECURSOR (PROTEIN IB) (PIB) (PORIN) (CLASS 3) - NEISSERIA MENINGITIDIS.
OMB3_NEIME MAJOR OUTER MEMBRANE PROTEIN P.IB PRECURSOR (PROTEIN IB) (PIB) (PORIN) (CLASS 3) - NEISSERIA MENINGITIDIS.
OMB4_NEIME MAJOR OUTER MEMBRANE PROTEIN P.IB PRECURSOR (PROTEIN IB) (PIB) (PORIN) (CLASS 3) - NEISSERIA MENINGITIDIS.
OMB_NEILA MAJOR OUTER MEMBRANE PROTEIN P.IB PRECURSOR (PROTEIN IB) (PIB) (PORIN) - NEISSERIA LACTAMICA.
OMB_NEISI MAJOR OUTER MEMBRANE PROTEIN P.IB PRECURSOR (PROTEIN IB) (PIB) (PORIN) - NEISSERIA SICCA.
OMPC_ECOLI OUTER MEMBRANE PROTEIN C PRECURSOR (PORIN OMPC) (OUTER MEMBRANE PROTEIN 1B) - ESCHERICHIA COLI.
OMPC_KLEPN OUTER MEMBRANE PROTEIN C PRECURSOR (PORIN OMPC) (PORIN OMPK36) - KLEBSIELLA PNEUMONIAE.
OMPC_SALTI OUTER MEMBRANE PROTEIN C PRECURSOR (PORIN OMPC) - SALMONELLA TYPHI.
OMPC_SALTY OUTER MEMBRANE PROTEIN C PRECURSOR (PORIN OMPC) - SALMONELLA TYPHIMURIUM.
OMPC_SERMA OUTER MEMBRANE PROTEIN C PRECURSOR (PORIN OMPC) - SERRATIA MARCESCENS.
OMPF_ECOLI OUTER MEMBRANE PROTEIN F PRECURSOR (PORIN OMPF) (OUTER MEMBRANE PROTEIN 1A, IA, OR B) - ESCHERICHIA COLI.
OMPF_SALTI OUTER MEMBRANE PROTEIN F PRECURSOR (PORIN OMPF) (OUTER MEMBRANE PROTEIN S3) - SALMONELLA TYPHI.
OMPF_SALTY OUTER MEMBRANE PROTEIN F PRECURSOR (PORIN OMPF) (OUTER MEMBRANE PROTEIN 1A, IA, OR B) - SALMONELLA TYPHIMURIUM.
OMPF_SERMA OUTER MEMBRANE PROTEIN F PRECURSOR (PORIN OMPF) - SERRATIA MARCESCENS.
OMPF_XENNE OUTER MEMBRANE PROTEIN F PRECURSOR (PORIN OMPF) (OUTER MEMBRANE PROTEIN OPNP) - XENORHABDUS NEMATOPHILUS.
OMPN_ECOLI OUTER MEMBRANE PROTEIN N PRECURSOR (PORIN OMPN) - ESCHERICHIA COLI.
OMS1_SALTI OUTER MEMBRANE PROTEIN S1 PRECURSOR - SALMONELLA TYPHI.
OMS2_SALTI OUTER MEMBRANE PROTEIN S2 PRECURSOR - SALMONELLA TYPHI.
P95344 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
P95345 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
P95346 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
P95347 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
P95348 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
P95349 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
P95350 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
P95351 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
P95352 OUTER MEMBRANE PROTEIN PIB PRECURSOR - NEISSERIA GONORRHOEAE.
PHOE_CITFR OUTER MEMBRANE PORE PROTEIN E PRECURSOR - CITROBACTER FREUNDII.
PHOE_ECOLI OUTER MEMBRANE PORE PROTEIN E PRECURSOR - ESCHERICHIA COLI.
PHOE_ENTCL OUTER MEMBRANE PORE PROTEIN E PRECURSOR - ENTEROBACTER CLOACAE.
PHOE_KLEOX OUTER MEMBRANE PORE PROTEIN E PRECURSOR - KLEBSIELLA OXYTOCA.
PHOE_KLEPN OUTER MEMBRANE PORE PROTEIN E PRECURSOR - KLEBSIELLA PNEUMONIAE.
PHOE_SALTI OUTER MEMBRANE PORE PROTEIN E PRECURSOR - SALMONELLA TYPHI.
PHOE_SALTY OUTER MEMBRANE PORE PROTEIN E PRECURSOR - SALMONELLA TYPHIMURIUM.
PORI_BPPA2 OUTER MEMBRANE PORIN PROTEIN LC PRECURSOR - BACTERIOPHAGE PA-2.
Q05520 MAJOR OUTER MEMBRANE PROTEIN P.IA PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA MENINGITIDIS.
Q08249 MAJOR OUTER MEMBRANE PROTEIN PI.A PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA GONORRHOEAE.
Q08250 MAJOR OUTER MEMBRANE PROTEIN PI.A PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA GONORRHOEAE.
Q08251 MAJOR OUTER MEMBRANE PROTEIN PI.A PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA GONORRHOEAE.
Q08252 MAJOR OUTER MEMBRANE PROTEIN PI.A PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA GONORRHOEAE.
Q08253 MAJOR OUTER MEMBRANE PROTEIN PI.A PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA GONORRHOEAE.
Q08254 MAJOR OUTER MEMBRANE PROTEIN PI.A PRECURSOR (PROTEIN IA) (PIA) - NEISSERIA GONORRHOEAE.
Q51056 PORIN (PORB) - NEISSERIA GONORRHOEAE.
Q51059 MAJOR OUTER MEMBRANE PROTEIN (PIB) PRECURSOR (PIB) - NEISSERIA GONORRHOEAE.
Q51066 OUTER MEMBRANE PROTEIN IA PRECURSOR - NEISSERIA GONORRHOEAE.
Q51067 OUTER MEMBRANE PROTEIN IA PRECURSOR - NEISSERIA GONORRHOEAE.
Q51068 OUTER MEMBRANE PROTEIN IA PRECURSOR - NEISSERIA GONORRHOEAE.
Q51093 CLASS 3 OUTER MEMBRANE PORIN PRECURSOR - NEISSERIA MENINGITIDIS.
Q51094 CLASS 3 OUTER MEMBRANE PORIN PRECURSOR - NEISSERIA MENINGITIDIS.
Q51095 CLASS 3 OUTER MEMBRANE PORIN PRECURSOR - NEISSERIA MENINGITIDIS.
Q51096 CLASS 3 OUTER MEMBRANE PORIN PRECURSOR - NEISSERIA MENINGITIDIS.
Q51100 CLASS 3 OUTER MEMBRANE PORIN PRECURSOR - NEISSERIA MENINGITIDIS.
Q51240 PORA A CLASS 1 OUTER MEMBRANE PROTEIN (P1.7,16) PRECURSOR (P1.7,16) - NEISSERIA MENINGITIDIS.
Q51261 PORB PROTEIN PRECURSOR - NEISSERIA MENINGITIDIS.
Q51271 SEROTYPE 15 OUTER MEMBRANE PROTEIN - NEISSERIA MENINGITIDIS.
Q57378 CLASS 3 OUTER MEMBRANE PORIN PRECURSOR - NEISSERIA MENINGITIDIS.
YEDS_ECOLI POTENTIAL OUTER MEMBRANE PROTEIN YEDS PRECURSOR - ESCHERICHIA COLI.
Q45106 OPCP1 - BURKHOLDERIA CEPACIA (PSEUDOMONAS CEPACIA).
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