| Literature References | 1. MUECKLER, M., CARUSO, C., BALDWIN, S.A., PANICO, M., BLENCH, I.,
MORRIS, H.R., ALLARD, W.J., LIENDER, G.E. AND LODISH, H.F.
Sequence and structure of a human glucose transporter.
SCIENCE 229 941-945 (1985).
2. MAIDEN, M.C.J., DAVIS, E.O., BALDWIN, S.A., MOORE, D.C.M.
AND HENDERSON P.J.F.
Mammalian and bacterial sugar transport proteins are homologous.
NATURE 325 641 (1987).
3. KAYANO, T., FUKUMOTO, H., EDDY, R.C., FAN, Y., BYERS, M.G., SHOWS, T.B.
AND BELL, G.I.
Evidence for a family of human glucose transporter-like proteins.
J.BIOL.CHEM. 263 15245-15248 (1988).
|
| Documentation | The sugar transporters belong to a family of membrane proteins responsible
for the transport of various sugars in a wide range of prokaryotic and
eukaryotic organisms [1]. The similarity between the sugar transporters in
such diverse organisms as bacteria and mammals is considered too great to
have arisen from convergent evolution. Gene transfer from eukaryotes to
their prokaryotic symbionts has been suggested, but it is more likely that
the transporters have evolved from an ancient protein present in living
organisms before the divergence into prokaryotes and eukaryotes [2]. In
mammals, these proteins are expressed in a number of organs [3].
SUGRTRNSPORT is a 5-element fingerprint that provides a signature for a
superfamily of sugar transporters. The fingerprint was derived from an
initial alignment of 12 sequences: the motifs were drawn largely from
transmembrane (TM) domains (i.e. 1, 4, 7 and 10), motif 5 corresponding to
the conserved loop between the tenth and eleventh TM regions (the
remaining TM domains were not sufficiently well conserved to be able to
characterise the superfamily). Three iterations on OWL11.0 were required
to reach convergence, at which point a true set comprising 32 sequences
was identified.
An update on SPTR37_9f identified a true set of 120 sequences, and 49
partial matches.
|
| Sequence Titles | ARAE_ECOLI ARABINOSE-PROTON SYMPORTER (ARABINOSE TRANSPORTER) - ESCHERICHIA COLI.
ARAE_KLEOX ARABINOSE-PROTON SYMPORTER (ARABINOSE TRANSPORTER) - KLEBSIELLA OXYTOCA.
GAL2_YEAST GALACTOSE TRANSPORTER (GALACTOSE PERMEASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
GALP_ECOLI GALACTOSE-PROTON SYMPORTER (GALACTOSE TRANSPORTER) - ESCHERICHIA COLI.
GHT3_SCHPO PROBABLE HIGH-AFFINITY GLUCOSE TRANSPORTER GHT3 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
GLCP_SYNY3 GLUCOSE TRANSPORT PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
GLF_ZYMMO GLUCOSE FACILITATED DIFFUSION PROTEIN - ZYMOMONAS MOBILIS.
GTR1_BOVIN GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN - BOS TAURUS (BOVINE).
GTR1_CHICK GLUCOSE TRANSPORTER TYPE 1 (GT1) - GALLUS GALLUS (CHICKEN).
GTR1_HUMAN GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN - HOMO SAPIENS (HUMAN).
GTR1_LEIDO MEMBRANE TRANSPORTER D1 - LEISHMANIA DONOVANI.
GTR1_MOUSE GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN (GT1) - MUS MUSCULUS (MOUSE).
GTR1_RABIT GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN - ORYCTOLAGUS CUNICULUS (RABBIT).
GTR1_RAT GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN - RATTUS NORVEGICUS (RAT).
GTR2_CHICK GLUCOSE TRANSPORTER TYPE 2, LIVER - GALLUS GALLUS (CHICKEN).
GTR2_HUMAN GLUCOSE TRANSPORTER TYPE 2, LIVER - HOMO SAPIENS (HUMAN).
GTR2_MOUSE GLUCOSE TRANSPORTER TYPE 2, LIVER - MUS MUSCULUS (MOUSE).
GTR2_RAT GLUCOSE TRANSPORTER TYPE 2, LIVER - RATTUS NORVEGICUS (RAT).
GTR3_CANFA GLUCOSE TRANSPORTER TYPE 3, BRAIN - CANIS FAMILIARIS (DOG).
GTR3_CHICK GLUCOSE TRANSPORTER TYPE 3 (CEF-GT3) - GALLUS GALLUS (CHICKEN).
GTR3_HUMAN GLUCOSE TRANSPORTER TYPE 3, BRAIN - HOMO SAPIENS (HUMAN).
GTR3_MOUSE GLUCOSE TRANSPORTER TYPE 3, BRAIN - MUS MUSCULUS (MOUSE).
GTR3_RAT GLUCOSE TRANSPORTER TYPE 3, BRAIN - RATTUS NORVEGICUS (RAT).
GTR3_SHEEP GLUCOSE TRANSPORTER TYPE 3, BRAIN - OVIS ARIES (SHEEP).
GTR4_BOVIN GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE - BOS TAURUS (BOVINE).
GTR4_HUMAN GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE - HOMO SAPIENS (HUMAN).
GTR4_MOUSE GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE (GT2) - MUS MUSCULUS (MOUSE).
GTR4_RAT GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE - RATTUS NORVEGICUS (RAT).
HEX6_RICCO HEXOSE CARRIER PROTEIN HEX6 - RICINUS COMMUNIS (CASTOR BEAN).
HGT1_KLULA HIGH-AFFINITY GLUCOSE TRANSPORTER - KLUYVEROMYCES LACTIS (YEAST).
HUP1_CHLKE H(+)/HEXOSE COTRANSPORTER 1 - CHLORELLA KESSLERI.
HUP2_CHLKE H(+)/HEXOSE COTRANSPORTER 2 (GALACTOSE-H+ SYMPORTER) - CHLORELLA KESSLERI.
HUP3_CHLKE H(+)/HEXOSE COTRANSPORTER 3 - CHLORELLA KESSLERI.
HXT0_YEAST HEXOSE TRANSPORTER HXT10 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT1_YEAST LOW-AFFINITY GLUCOSE TRANSPORTER HXT1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT2_YEAST HIGH-AFFINITY GLUCOSE TRANSPORTER HXT2 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT3_YEAST LOW-AFFINITY GLUCOSE TRANSPORTER HXT3 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT4_YEAST LOW-AFFINITY GLUCOSE TRANSPORTER HXT4 (LOW-AFFINITY GLUCOSE TRANSPORTER LGT1) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT5_YEAST PROBABLE GLUCOSE TRANSPORTER HXT5 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT6_YEAST HIGH AFFINITY HEXOSE TRANSPORTER HXT6 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT7_YEAST HIGH AFFINITY HEXOSE TRANSPORTER HXT6 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT8_YEAST HEXOSE TRANSPORTER HXT8 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXT9_YEAST HEXOSE TRANSPORTER HXT9 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXTA_YEAST HEXOSE TRANSPORTER HXT11 (LOW-AFFINITY GLUCOSE TRANSPORTER LGT3) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXTC_YEAST HEXOSE TRANSPORTER HXT13 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXTD_YEAST HEXOSE TRANSPORTER HXT14 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXTE_YEAST HEXOSE TRANSPORTER HXT15 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXTF_YEAST HEXOSE TRANSPORTER HXT16 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXTG_YEAST HEXOSE TRANSPORTER HXT17 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
ITR1_SCHPO MYO-INOSITOL TRANSPORTER 1 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
ITR1_YEAST MYO-INOSITOL TRANSPORTER 1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
ITR2_SCHPO MYO-INOSITOL TRANSPORTER 2 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
ITR2_YEAST MYO-INOSITOL TRANSPORTER 2 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
KHT2_KLULA HEXOSE TRANSPORTER 2 - KLUYVEROMYCES LACTIS (YEAST).
O04078 MONOSACCHARID TRANSPORT PROTEIN - VICIA FABA (BROAD BEAN).
O04249 T10M13.6 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O05182 XYLOSE PERMEASE - BACILLUS MEGATERIUM.
O13346 HEXOSE TRANSPORTER - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O13411 AMMST-1 - AMANITA MUSCARIA (FLY AGARIC).
O13477 PUTATIVE GLUCOSE SENSOR - KLUYVEROMYCES LACTIS (YEAST).
O22848 MEMBRANE TRANSPORTER D1 ISOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O23213 MYO-INOSITOL TRANSPORT PROTEIN HOMOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O23492 SIMILARITY TO MEMBRANE TRANSPORT PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O24245 PAMST-1 - PICEA ABIES (NORWAY SPRUCE) (PICEA EXCELSA).
O32289 HYPOTHETICAL METABOLITE TRANSPORT PROTEIN IN IOLS-HTPG INTERGENIC REGION - BACILLUS SUBTILIS.
O34718 METABOLITE TRANSPORT PROTEIN - BACILLUS SUBTILIS.
O44616 R09B5.11 PROTEIN - CAENORHABDITIS ELEGANS.
O48537 PUTATIVE SUGAR TRANSPORTER - PRUNUS ARMENIACA (APRICOT).
O53381 SUGAR TRANSPORT PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O59932 PUTATIVE GLUCOSE TRANSPORTER PROTEIN - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O65322 PUTATIVE MONOSACCHARIDE TRANSPORTER 1 - PETUNIA HYBRIDA (PETUNIA).
O65413 GLUCOSE TRANSPORTER - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O65497 PUTATIVE SUGAR TRANSPORTER PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O74849 HEXOSE TRANSPORTER - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O74969 HECOSE TRANSPORTER - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O76234 GLUCOSE TRANSPORTER - TRYPANOSOMA CONGOLENSE.
O76235 GLUCOSE TRANSPORTER - TRYPANOSOMA CONGOLENSE.
O76486 GLUCOSE TRANSPORTER - LEISHMANIA MEXICANA.
O77131 GLUCOSE TRANSPORTER 1 - DROSOPHILA MELANOGASTER (FRUIT FLY).
O80655 PUTATIVE MONOSACCHARIDE TRANSPORT PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O81492 F9D12.9 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O81501 F9D12.17 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O82000 HEXOSE TRANSPORTER PROTEIN - LYCOPERSICON ESCULENTUM (TOMATO).
O82847 XYLOSE TRANSPORTER - TETRAGENOCOCCUS HALOPHILUS (PEDIOCOCCUS HALOPHILUS).
P46327
P78831 PUTATIVE GLUCOSE TRANSPORTER PROTEIN - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
P93075 PUTATIVE SUGAR TRANSPORTER (BVCDNA-205) - BETA VULGARIS (SUGAR BEET).
P93076 PUTATIVE SUGAR TRANSPORTER (BVCDNA-397) - BETA VULGARIS (SUGAR BEET).
P94493 YNCC - BACILLUS SUBTILIS.
P96710 PERMEASE (TRANSMEMBRANE PROTEIN) (ARAE) - BACILLUS SUBTILIS.
P96742 SIMILAR TO METABOLITE TRANSPORT PROTEINS - BACILLUS SUBTILIS.
PRO1_LEIEN PROBABLE TRANSPORT PROTEIN (LTP) - LEISHMANIA ENRIETTII.
Q06312 H(+)/MONOSACCHARIDE COTRANSPORTER - NICOTIANA TABACUM (COMMON TOBACCO).
Q21455 M01F1.5 PROTEIN - CAENORHABDITIS ELEGANS.
Q26579 GLUCOSE TRANSPORT PROTEIN - SCHISTOSOMA MANSONI (BLOOD FLUKE).
Q26580 GLUCOSE TRANSPORT PROTEIN - SCHISTOSOMA MANSONI (BLOOD FLUKE).
Q26581 GLUCOSE TRANSPORT PROTEIN - SCHISTOSOMA MANSONI (BLOOD FLUKE).
Q26765 HEXOSE TRANSPORTER - TRYPANOSOMA BRUCEI BRUCEI.
Q26858 HEXOSE TRANSPORTER - TRYPANOSOMA CRUZI.
Q27072 TGTP1 - TAENIA SOLIUM.
Q27079 GLUCOSE TRANSPORTER TGTP2 - TAENIA SOLIUM.
Q27115 GLUCOSE TRANSPORTER HT1 - TRYPANOSOMA VIVAX.
Q39228 SUGAR TRANSPORT PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q40373 SUGAR TRANSPORTER - MEDICAGO TRUNCATULA (BARREL MEDIC).
Q41409 GLUCOSE TRANSPORTER - SACCHARUM HYBRID (SUGARCANE).
QAY_NEUCR QUINATE PERMEASE (QUINATE TRANSPORTER) - NEUROSPORA CRASSA.
QUTD_EMENI QUINATE PERMEASE (QUINATE TRANSPORTER) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
RAG1_KLULA LOW-AFFINITY GLUCOSE TRANSPORTER - KLUYVEROMYCES LACTIS (YEAST).
RCO3_NEUCR PROBABLE GLUCOSE TRANSPORTER RCO-3 - NEUROSPORA CRASSA.
RGT2_YEAST HIGH-AFFINITY GLUCOSE TRANSPORTER RGT2 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
SNF3_YEAST HIGH-AFFINITY GLUCOSE TRANSPORTER SNF3 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
STA_RICCO SUGAR CARRIER PROTEIN A - RICINUS COMMUNIS (CASTOR BEAN).
STC_RICCO SUGAR CARRIER PROTEIN C - RICINUS COMMUNIS (CASTOR BEAN).
STP1_ARATH GLUCOSE TRANSPORTER (SUGAR CARRIER) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
TH11_TRYBB GLUCOSE TRANSPORTER 1B/1C/1D/1F/2B - TRYPANOSOMA BRUCEI BRUCEI.
TH12_TRYBB GLUCOSE TRANSPORTER 1E - TRYPANOSOMA BRUCEI BRUCEI.
TH2A_TRYBB GLUCOSE TRANSPORTER 2A - TRYPANOSOMA BRUCEI BRUCEI.
XYLE_ECOLI D-XYLOSE-PROTON SYMPORTER (D-XYLOSE TRANSPORTER) - ESCHERICHIA COLI.
XYLT_LACBR D-XYLOSE-PROTON SYMPORTER (D-XYLOSE TRANSPORTER) - LACTOBACILLUS BREVIS.
YFIG_BACSU HYPOTHETICAL METABOLITE TRANSPORT PROTEIN IN GLVBC 3'REGION - BACILLUS SUBTILIS.
GTR5_HUMAN GLUCOSE TRANSPORTER TYPE 5, SMALL INTESTINE (FRUCTOSE TRANSPORTER) - HOMO SAPIENS (HUMAN).
GTR5_RAT GLUCOSE TRANSPORTER TYPE 5, SMALL INTESTINE (FRUCTOSE TRANSPORTER) - RATTUS NORVEGICUS (RAT).
O04036 HYPOTHETICAL 52.2 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O04037 HYPOTHETICAL 49.9 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O49270 F1N21.10 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O61059 LMGT1 - LEISHMANIA MEXICANA.
O61060 LMGT2 - LEISHMANIA MEXICANA.
O65799 ERD6 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O74713 HIGH-AFFINITY GLUCOSE TRANSPORTER - CANDIDA ALBICANS (YEAST).
Q04162 D9509.7P - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q14770 FRUCTOSE TRANSPORTER - HOMO SAPIENS (HUMAN).
STL1_YEAST SUGAR TRANSPORTER STL1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YIR0_YEAST HYPOTHETICAL 50.8 KD PROTEIN IN SDL1 5'REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
GTR2_LEIDO MEMBRANE TRANSPORTER D2 - LEISHMANIA DONOVANI.
O04040 HYPOTHETICAL 42.2 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O04041 HYPOTHETICAL 55.4 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O13311 HEXOSE TRANSPORTER - ASPERGILLUS PARASITICUS.
O45920 Y37A1A.3 PROTEIN - CAENORHABDITIS ELEGANS.
O45949 Y45F10E.1.
P95908 SUGAR TRANSPORTER - SULFOLOBUS SOLFATARICUS.
Q20734 SIMILAR TO GLUCOSE TRANSPORTER. NCBI GI: 1086689 - CAENORHABDITIS ELEGANS.
Q39416 INTEGRAL MEMBRANE PROTEIN - BETA VULGARIS (SUGAR BEET).
Q96290 SUGAR TRANSPORTER - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
YB91_YEAST PROBABLE METABOLITE TRANSPORT PROTEIN YBR241C - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YGK4_YEAST PROBABLE METABOLITE TRANSPORT PROTEIN YGL104C - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
GTR5_RABIT GLUCOSE TRANSPORTER TYPE 5, SMALL INTESTINE (FRUCTOSE TRANSPORTER) - ORYCTOLAGUS CUNICULUS (RABBIT).
GTRL_DROME GLUCOSE TRANSPORTER-LIKE PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
O16547 C35A11.4 PROTEIN - CAENORHABDITIS ELEGANS.
O25723 ALPHA-KETOGLUTARATE PERMEASE (KGTP) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O26207 MULTIDRUG TRANSPORTER HOMOLOG - METHANOBACTERIUM THERMOAUTOTROPHICUM.
O28265 SUGAR TRANSPORTER, PUTATIVE - ARCHAEOGLOBUS FULGIDUS.
O74639 PHOSPHATE PERMEASE - GIBBERELLA ZEAE (FUSARIUM GRAMINEARUM).
Q00908 PHOSPHATE TRANSPORTER - GLOMUS VERSIFORME.
Q07824 CHROMOSOME XII READING FRAME ORF YLL028W - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q12407 ORF YDL199C - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q20565 SIMILAR TO GLUCOSE TRANSPORTER - CAENORHABDITIS ELEGANS.
Q23535 SIMILARITY TO TRANSMEMBRANE DOMAINS LIKE THOSE FOUND IN SUGAR TRANSPORTER PROTEINS - CAENORHABDITIS ELEGANS.
YAAU_ECOLI HYPOTHETICAL METABOLITE TRANSPORT PROTEIN IN CARB-KEFC INTERGENIC REGION (ORF65/66) - ESCHERICHIA COLI.
YFE0_YEAST PROBABLE METABOLITE TRANSPORT PROTEIN YFL040W - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YGCS_ECOLI HYPOTHETICAL METABOLITE TRANSPORT PROTEIN IN CYSJ-ENO INTERGENIC REGION - ESCHERICHIA COLI.
|