| Literature References | 1. KELLY, A., POWIS, S.H., GLYNNE, R., RADLEY, E., BECK, S. AND
TROWSDALE, J.
Second proteasome related gene in the human MHC class II region.
NATURE 353 667-668 (1991).
2. AKI, M., TAMURA, T., TOKUNAGA, F., IWANAGA, S., KAWAMURA, Y., SHIMBARA, N.,
KAGAWA, S., TANAKA, K. AND ICHIHARA, A.
cDNA Cloning of rat proteasome subunit RC1, a homolog of RING10 located in
the human MHC class II region.
FEBS LETT. 301(1) 65-68 (1992).
3. GLYNNE, R., POWIS, S.H., BECK, S., KELLY, A., KERR, L. AND TROWSDALE, J.
A proteasome related gene between the 2 ABC transporter loci in the class
II region of the human MHC.
NATURE 353 357-360 (1991).
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| Documentation | The proteasome is a novel type of intracellular complex of approximately 15
subunits with multiple proteolytic activities [1], and is variously known
as multicatalytic endopeptidase complex, multicatalytic proteinase complex,
or prosome. Homologues of these subunits are thought to be involved in
antigen processing, although there is no direct evidence of proteasome
involvement [2]. These homologues are located between the 2 transporter
proteins of the major histocompatability complex I (MHCI) [3], and it is
thought that they process intracellular antigens by proteolytically
cleaving them. The resulting peptides are then transported to the endo-
plasmic reticulum via the 2 transporters on MHC I, and are then presented
to the cell surface where the are recognised by T-cells.
PROTEASOME is a 4-element fingerprint that provides a signature for
proteasome components. The fingerprint was derived from an initial
alignment of 6 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, motif 1 including part of the
region encoded by PROSITE pattern PROTEASOME_B (PS00854). Two iterations on
OWL19.1 were required to reach convergence, at which point a true set
comprising 12 sequences was identified. Two proteasome fragments were also
found (fragments shorter than 20 residues are not identified by the
fingerprint).
An update on SPTR37_9f identified a true set of 44 sequences, and 10
partial matches.
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| Sequence Titles | O12992 PROTEASOME SUBUNIT Y - LAMPETRA JAPONICA (JAPANESE LAMPREY).
O12999 LMP2 (EC 3.4.99.46) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O13000 PROTEASOME SUBUNIT Y (EC 3.4.99.46) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O23716 MULTICATALYTIC ENDOPEPTIDASE COMPLEX, PROTEASOME PRECURSOR, BETA SUBUNIT (EC 3.4.99.46) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O35521 LOW MOLECULAR MASS POLYPEPTIDE COMPLEX SUBUNIT 2 (EC 3.4.99.46) - MUS DUNNI.
O35522 LOW MOLECULAR MASS POLYPEPTIDE COMPLEX SUBUNIT 2 (EC 3.4.99.46) - MUS MUSCULUS BACTRIANUS (SOUTHWESTERN ASIAN HOUSE MOUSE).
O35523 LOW MOLECULAR MASS POLYPEPTIDE COMPLEX SUBUNIT 2 (EC 3.4.99.46) - MUS PLATYTHRIX.
O35524 LOW MOLECULAR MASS POLYPEPTIDE COMPLEX SUBUNIT 2 (EC 3.4.99.46) - MUS SPICILEGUS (STEPPE MOUSE).
O43063 PROTEASOME COMPONENT PRECURSOR - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O50110 207AA LONG HYPOTHETICAL PROTEASOME BETA SUBUNIT PRECURSOR (EC 3.4.99.46) - PYROCOCCUS HORIKOSHII.
O57330 LMP7 (EC 3.4.99.46) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O57332 PROTEASOME SUBUNIT Y (EC 3.4.99.46) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O60953 PROTEASOME SUBUNIT (EC 3.4.99.46) - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
O62102 C47B2.4 PROTEIN (EC 3.4.99.46) - CAENORHABDITIS ELEGANS.
P90725 LMP7-LIKE PROTEIN (EC 3.4.99.46) - BOTRYLLUS SCHLOSSERI.
P91729 LMP7-LIKE PROTEIN (EC 3.4.99.46) - GEODIA CYDONIUM (SPONGE).
PRC7_HUMAN PROTEASOME CHAIN 7 PRECURSOR (EC 3.4.99.46) (MACROPAIN CHAIN 7) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX CHAIN 7) (RING12 PROTEIN) - HOMO SAPIENS (HUMAN).
PRC7_MOUSE PROTEASOME CHAIN 7 PRECURSOR (EC 3.4.99.46) (MACROPAIN CHAIN 7) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX CHAIN 7) (RING12 PROTEIN) - MUS MUSCULUS (MOUSE).
PRC7_RAT PROTEASOME CHAIN 7 PRECURSOR (EC 3.4.99.46) (MACROPAIN CHAIN 7) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX CHAIN 7) (RING12 PROTEIN) - RATTUS NORVEGICUS (RAT).
PRCB_METJA PROTEASOME BETA SUBUNIT (EC 3.4.99.46) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX BETA SUBUNIT) - METHANOCOCCUS JANNASCHII.
PRCB_THEAC PROTEASOME BETA SUBUNIT PRECURSOR (EC 3.4.99.46) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX BETA SUBUNIT) - THERMOPLASMA ACIDOPHILUM.
PRCD_HUMAN PROTEASOME DELTA CHAIN PRECURSOR (EC 3.4.99.46) (MACROPAIN DELTA CHAIN) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX DELTA CHAIN) (PROTEASOME SUBUNIT Y) - HOMO SAPIENS (HUMAN).
PRCD_TOBAC PROTEASOME DELTA CHAIN PRECURSOR (EC 3.4.99.46) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX DELTA CHAIN) - NICOTIANA TABACUM (COMMON TOBACCO).
PRCD_YEAST PROTEASOME COMPONENT PRE3 PRECURSOR (EC 3.4.99.46) (MACROPAIN SUBUNIT PRE3) (PROTEINASE YSCE SUBUNIT PRE3) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE3) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
PRCE_ARATH PROTEASOME EPSILON CHAIN PRECURSOR (EC 3.4.99.46) (MACROPAIN EPSILON CHAIN) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX EPSILON CHAIN) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
PRCE_HUMAN PROTEASOME EPSILON CHAIN PRECURSOR (EC 3.4.99.46) (MACROPAIN EPSILON CHAIN) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX EPSILON CHAIN) (PROTEASOME SUBUNIT X) (PROTEASOME CHAIN 6) (PROTEASOME SUBUNIT MB1) - HOMO SAPIENS (HUMAN).
PRCE_MOUSE PROTEASOME EPSILON CHAIN PRECURSOR (EC 3.4.99.46) (MACROPAIN EPSILON CHAIN) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX EPSILON CHAIN) (PROTEASOME SUBUNIT X) (PROTEASOME CHAIN 6) - MUS MUSCULUS (MOUSE).
PRCE_RAT PROTEASOME EPSILON CHAIN PRECURSOR (EC 3.4.99.46) (MACROPAIN EPSILON CHAIN) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX EPSILON CHAIN) (PROTEASOME SUBUNIT X) (PROTEASOME CHAIN 6) - RATTUS NORVEGICUS (RAT).
PRCE_SCHPO PROTEASOME COMPONENT PTS1 PRECURSOR (EC 3.4.99.46) (MACROPAIN SUBUNIT PTS1) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PTS1) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
PRCE_SPIOL PROTEASOME EPSILON CHAIN PRECURSOR (EC 3.4.99.46) (MACROPAIN EPSILON CHAIN) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX EPSILON CHAIN) - SPINACIA OLERACEA (SPINACH).
PRCE_YEAST PROTEASOME COMPONENT PRE2 PRECURSOR (EC 3.4.99.46) (MACROPAIN SUBUNIT PRE2) (PROTEINASE YSCE SUBUNIT PRE2) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE2) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
PRCY_HUMAN PROTEASOME COMPONENT C13 PRECURSOR (EC 3.4.99.46) (MACROPAIN SUBUNIT C13) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C13) - HOMO SAPIENS (HUMAN).
PRCY_MOUSE PROTEASOME COMPONENT C13 PRECURSOR (EC 3.4.99.46) (MACROPAIN SUBUNIT C13) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C13) - MUS MUSCULUS (MOUSE).
Q16523 PROTEASOME-RELATED (EC 3.4.99.46) (LMP-2) - HOMO SAPIENS (HUMAN).
Q50534 PROTEASOME BETA SUBUNIT PRECURSOR (EC 3.4.99.46) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX BETA SUBUNIT) - METHANOSARCINA THERMOPHILA.
Q60692 DELTA PROTEASOME SUBUNIT (EC 3.4.99.46) - MUS MUSCULUS (MOUSE).
Q60693 PROTEASOME (PROSOME, MACROPAIN) SUBUNIT, BETA TYPE 6 (DELTA PROTEASOME SUBUNIT) - MUS MUSCULUS (MOUSE).
Q60827 LARGE MULTIFUNCTIONAL PROTEASE 2 (EC 3.4.99.46) (20S PROTEASOME SUBUNIT LMP2) - MUS MUSCULUS (MOUSE).
Q64278 LARGE MULTIFUNCTIONAL PROTEASE 2 (EC 3.4.99.46) (20S PROTEASOME SUBUNIT LMP2) - MUS MUSCULUS (MOUSE), AND MUS MUSCULUS MOLOSSINUS.
Q90570 LMP7 OF NURSE SHARK - GINGLYMOSTOMA CIRRATUM (NURSE SHARK).
Q90571 LMP7 (EC 3.4.99.46) - GINGLYMOSTOMA CIRRATUM (NURSE SHARK).
Q91087 LMPX OF HAGFISH (EC 3.4.99.46) - MYXINE GLUTINOSA (ATLANTIC HAGFISH).
Q91787 LOW MOLECULAR MASS PROTEIN-7 (LMP-7) HOMOLOG (EC 3.4.99.46) (LMP-7) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q91788 LOW MOLECULAR MASS PROTEIN-7 (LMP-7) HOMOLOG (EC 3.4.99.46) (LMP-7) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O23710 MULTICATALYTIC ENDOPEPTIDASE (EC 3.4.99.46) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O27270 PROTEASOME, BETA SUBUNIT - METHANOBACTERIUM THERMOAUTOTROPHICUM.
O29769 PROTEASOME BETA SUBUNIT (EC 3.4.99.46) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX BETA SUBUNIT) - ARCHAEOGLOBUS FULGIDUS.
O81152 20S PROTEASOME BETA SUBUNIT PBB1 (EC 3.4.99.46) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O17311 20S PROTEASOME BETA2 SUBUNIT (EC 3.4.99.46) - DROSOPHILA MELANOGASTER (FRUIT FLY).
O17312 20S PROTEASOME BETA2 SUBUNIT (EC 3.4.99.46) - DROSOPHILA MELANOGASTER (FRUIT FLY).
O59219 260AA LONG HYPOTHETICAL PROTEASOME, ALPHA SUBUNIT - PYROCOCCUS HORIKOSHII.
O87598 20S PROTEASOME BETA-SUBUNIT PRECURSOR - STREPTOMYCES COELICOLOR.
PRCF_SCHPO PUTATIVE PROTEASOME COMPONENT PUP1 PRECURSOR (EC 3.4.99.46) (MACROPAIN SUBUNIT) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
PRCF_YEAST PROTEASOME COMPONENT PUP1 PRECURSOR (EC 3.4.99.46) (MACROPAIN SUBUNIT PUP1) (PROTEINASE YSCE SUBUNIT PUP1) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP1) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
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