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PR00102

Identifier
OTCASE  [View Relations]  [View Alignment]  
Accession
PR00102
No. of Motifs
5
Creation Date
11-MAR-1992  (UPDATE 30-JUN-1999)
Title
Ornithine carbamoyltransferase signature
Database References
PRINTS; PR00100 AOTCASE
INTERPRO; IPR002292
Literature References
1. MARTIN, P.R., COOPERIDER, J.W. AND MULKS, M.H. 
Sequence of the argf gene encoding ornithine transcarbamoylase from 
Neisseria gonorrhoeae. 
GENE 94 139-140 (1990).
 
2. BAUR, H., STALON, V., FALMAGNE, P., LUETHI, E. AND HAAS, D. 
Primary and quaternary structure of the catabolic ornithine 
carbamoyltransferase from Pseudomonas aeruginosa. 
EUR.J.BIOCHEMISTRY 166 111-117 (1987).
 
3. HUYGEN, R., CRABEEL, M. AND GLANSDORFF, N. 
Nucleotide sequence of the ARG3 gene of the yeast Saccharomyces cerevisiae 
encoding ornithine carbamoyltransferase. 
EUR.J.BIOCHEMISTRY 166 371-377 (1987).
 
4. UPSHALL, A., GILBERT, T., SAARI, G., O'HARA, P.J., WEGLENSKI, P., BERSE,
B., MILLER, K. AND TIMBERLAKE, W.E.  
Molecular analysis of the argB gene of Aspergillus nidulans. 
MOL.GEN.GENET. 204 349-354 (1986).
 
5. MOSQUEDA, G., VAN DEN BROECK, G., SAUCEDO, O., BAILEY, A.M.,
ALVAREZ-MORALES, A. AND HERRERA-ESTRELLA, L. 
Isolation and characterization of the gene from Pseudomonas syringae pv. 
phaseolicola encoding the phaseolotoxin insensitive ornithine 
carbamoyltransferase.
MOL.GEN.GENET. 222 461-466 (1990).

Documentation
The ornithine carbamoyltransferases are a family of enzymes that catalyse 
the production of citrulline from carbamoyl-phosphate and ornithine [1]. 
This reaction is part of the arginine biosynthetic pathway, and in some 
organisms the reaction is also part of the arginine deaminase pathway [2]. 
In most prokaryotes, and some lower eukaryotes, the enzyme is found in the 
cytoplasm, but in higher eukaryotes, such as mammals, the enzyme is found
in the mitochondrial matrix and functions as part of the urea cycle. In
most organisms analysed to date, the enzyme has been shown to consist of a 
trimer of identical or nonidentical subunits [3]. Extensive similarity has 
been found within the ornithine carbamoyltransferase family, some of the
conserved areas being important in catalysis [4].  
 
The C-terminal region of these enzymes shows a degree of similarity to the 
aspartate carbamoyltransferases, which are also known to bind carbamoyl-
phosphate [5]. This region contains a highly conserved Cys residue (in a
His-Cys-Lys-Pro motif) implicated in ornithine binding [3].
 
OTCASE is a 5-element fingerprint that provides a signature for ornithine
carbamoyltransferases. The fingerprint was derived from an initial
alignment of 5 sequences: motifs 1 (cf. PROSITE pattern CARBAMOYLTRANSFERASE
(PS00097)) and 3 contain residues thought to be involved in carbamoyl-
phosphate binding. Two iterations on OWL15.0 were required to reach
convergence, at which point a true set comprising 18 sequences was
identified. Several partial matches were also found.
 
An update on SPTR37_9f identified a true set of 43 sequences, and 7
partial matches.
Summary Information
  43 codes involving  5 elements
1 codes involving 4 elements
0 codes involving 3 elements
6 codes involving 2 elements
Composite Feature Index
54343434343
401111
300000
264101
12345
True Positives
O51782        O51897        O53089        O58457        
O67607 O76458 O86132 O87319
OTC1_ECOLI OTC2_ECOLI OTCA_BACSU OTCA_LACPL
OTCA_MYCBO OTCA_MYCTU OTCA_PSEAE OTCA_PSESH
OTCA_SYNY3 OTCA_THEMA OTCA_VIBS2 OTCC_CLOPE
OTCC_HAEIN OTCC_NEIGO OTCC_PSEAE OTCC_PSESH
OTCC_RHIET OTC_ARATH OTC_ARCFU OTC_ASPNG
OTC_ASPTE OTC_CORHI OTC_EMENI OTC_HALSA
OTC_HUMAN OTC_METJA OTC_METTH OTC_MOUSE
OTC_PACTA OTC_PEA OTC_PYRFU OTC_RANCA
OTC_RAT OTC_SCHPO OTC_YEAST
True Positive Partials
Codes involving 4 elements
OTCC_MYCPN
Codes involving 2 elements
O15804 PYRB_ARCFU PYRB_METJA PYRB_MYCTU
PYRB_SERMA PYRB_SYNY3
Sequence Titles
O51782      ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (ARCB) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE). 
O51897 ARCB - BORRELIA AFZELII.
O53089 ORNITHINE TRANSCARBAMOYLASE (EC 2.1.3.3) (ORNITHINE CARBAMOYLTRANSFERASE) (ORNITHINE TRANSCARBAMYLASE) (CITRULLINE PHOSPHORYLASE) (OTCASE) (OTC) - LACTOBACILLUS SAKE.
O58457 317AA LONG HYPOTHETICAL ORNITHINE CARBAMOYLTRANSFERASE - PYROCOCCUS HORIKOSHII.
O67607 ORNITHINE CARBAMOYLTRANSFERASE - AQUIFEX AEOLICUS.
O76458 ORNITHINE CARBAMOYLTRANSFERASE - GIARDIA INTESTINALIS.
O86132 ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) - BACILLUS LICHENIFORMIS.
O87319 ORNITHINE CARBAMOYLTRANSFERASE - NOSTOC PCC73102.
OTC1_ECOLI ORNITHINE CARBAMOYLTRANSFERASE CHAIN I (EC 2.1.3.3) (OTCASE-1) - ESCHERICHIA COLI.
OTC2_ECOLI ORNITHINE CARBAMOYLTRANSFERASE CHAIN F (EC 2.1.3.3) (OTCASE-2) - ESCHERICHIA COLI.
OTCA_BACSU ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - BACILLUS SUBTILIS.
OTCA_LACPL ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - LACTOBACILLUS PLANTARUM.
OTCA_MYCBO ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - MYCOBACTERIUM BOVIS.
OTCA_MYCTU ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - MYCOBACTERIUM TUBERCULOSIS.
OTCA_PSEAE ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - PSEUDOMONAS AERUGINOSA.
OTCA_PSESH ORNITHINE CARBAMOYLTRANSFERASE, PHASEOLOTOXIN-SENSITIVE, ANABOLIC (EC 2.1.3.3) (OTCASE) - PSEUDOMONAS SYRINGAE (PV. PHASEOLICOLA).
OTCA_SYNY3 ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
OTCA_THEMA ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - THERMOTOGA MARITIMA.
OTCA_VIBS2 ORNITHINE CARBAMOYLTRANSFERASE, ANABOLIC (EC 2.1.3.3) (OTCASE) - VIBRIO SP. (STRAIN 2693).
OTCC_CLOPE ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (EC 2.1.3.3) (OTCASE) - CLOSTRIDIUM PERFRINGENS.
OTCC_HAEIN ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (EC 2.1.3.3) (OTCASE) - HAEMOPHILUS INFLUENZAE.
OTCC_NEIGO ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (EC 2.1.3.3) (OTCASE) - NEISSERIA GONORRHOEAE.
OTCC_PSEAE ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (EC 2.1.3.3) (OTCASE) - PSEUDOMONAS AERUGINOSA.
OTCC_PSESH ORNITHINE CARBAMOYLTRANSFERASE, PHASEOLOTOXIN-INSENSITIVE, CATABOLIC (EC 2.1.3.3) (OTCASE) - PSEUDOMONAS SYRINGAE (PV. PHASEOLICOLA), AND PSEUDOMONAS SYRINGAE (PV. ACTINIDIAE).
OTCC_RHIET ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (EC 2.1.3.3) (OTCASE) - RHIZOBIUM ETLI.
OTC_ARATH ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
OTC_ARCFU ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) - ARCHAEOGLOBUS FULGIDUS.
OTC_ASPNG ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - ASPERGILLUS NIGER.
OTC_ASPTE ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - ASPERGILLUS TERREUS.
OTC_CORHI ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - CORIOLUS HIRSUTUS.
OTC_EMENI ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
OTC_HALSA ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) - HALOBACTERIUM SALINARIUM.
OTC_HUMAN ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - HOMO SAPIENS (HUMAN).
OTC_METJA ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) - METHANOCOCCUS JANNASCHII.
OTC_METTH ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) - METHANOBACTERIUM THERMOAUTOTROPHICUM.
OTC_MOUSE ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - MUS MUSCULUS (MOUSE).
OTC_PACTA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - PACHYSOLEN TANNOPHILUS (YEAST).
OTC_PEA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - PISUM SATIVUM (GARDEN PEA).
OTC_PYRFU ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) - PYROCOCCUS FURIOSUS.
OTC_RANCA ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - RANA CATESBEIANA (BULL FROG).
OTC_RAT ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - RATTUS NORVEGICUS (RAT).
OTC_SCHPO ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
OTC_YEAST ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3) (OTCASE) (ORNITHINE TRANSCARBAMYLASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).

OTCC_MYCPN ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC (EC 2.1.3.3) (OTCASE) - MYCOPLASMA PNEUMONIAE.

O15804 ASPARTATE TRANSCARBAMOYLASE (EC 2.1.3.2) - PLASMODIUM FALCIPARUM.
PYRB_ARCFU ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - ARCHAEOGLOBUS FULGIDUS.
PYRB_METJA ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - METHANOCOCCUS JANNASCHII.
PYRB_MYCTU ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - MYCOBACTERIUM TUBERCULOSIS.
PYRB_SERMA ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - SERRATIA MARCESCENS.
PYRB_SYNY3 ASPARTATE CARBAMOYLTRANSFERASE (EC 2.1.3.2) (ASPARTATE TRANSCARBAMYLASE) (ATCASE) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Scan History
OWL15_0    2  100  NSINGLE    
OWL17_1 1 100 NSINGLE
OWL19_1 1 100 NSINGLE
OWL26_0 1 250 NSINGLE
SPTR37_9f 3 100 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
LIFEKDSTRTRCSFE OTC2_ECOLI 49 49 -
LIFEKTSTRTRCAFE OTCC_PSEAE 50 50 -
MIFEKSSTRTRVSFE OTC2_BACSU 51 51 -
LIFNKRSTRTRVSSE OTC_PACTA 78 78 -
MIFEKRSTRTRLSTE OTC_HUMAN 84 84 -

Motif 2 width=14
Element Seqn Id St Int Rpt
QLGVNESLHDTTKI OTC_PACTA 111 18 -
QLGRGETVADTAKV OTC2_BACSU 84 18 -
QIGHKESIKDTARV OTC2_ECOLI 82 18 -
QIGHKESMKDTARV OTCC_PSEAE 83 18 -
HLGVNESLTDTARV OTC_HUMAN 117 18 -

Motif 3 width=15
Element Seqn Id St Int Rpt
IPIINGLSDLYHPIQ OTC_HUMAN 157 26 -
VPIINALCDTFHPLQ OTC_PACTA 151 26 -
VPVWNGLTNEFHPTQ OTC2_ECOLI 122 26 -
IPVINGLTDKYHPCQ OTC2_BACSU 124 26 -
VPVFNGLTDEYHPTQ OTCC_PSEAE 123 26 -

Motif 4 width=11
Element Seqn Id St Int Rpt
LITDTWISMGR OTC_HUMAN 260 88 -
IYSDVFTSMGQ OTC2_BACSU 227 88 -
IYTDVWVSMGE OTC2_ECOLI 228 91 -
VHTDVWVSMGE OTCC_PSEAE 228 90 -
IVTDTWISMGQ OTC_PACTA 255 89 -

Motif 5 width=12
Element Seqn Id St Int Rpt
NIAFEQAENRMH OTCC_PSEAE 311 72 -
SLVFEEGENRLY OTC_PACTA 319 53 -
SIVFDQAENRMH OTC2_ECOLI 310 71 -
SAVFQQAENRLH OTC2_BACSU 289 51 -
SLVFPEAENRKW OTC_HUMAN 321 50 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
LIFEKDSTRTRCSFE OTC1_ECOLI 49 49 -
LIFEKDSTRTRCSFE OTC2_ECOLI 49 49 -
MIFELPSTRTRVSFE OTC_ARCFU 45 45 -
MIFEKSSTRTRVSFE OTC_METTH 40 40 -
LLFEKPSTRTRCAFT O86132 53 53 -
MIFQKPSTRTRVSFE O58457 51 51 -
MIFQKPSTRTRVSFE OTC_PYRFU 51 51 -
IIFEKDSTRTRCAFE O51897 50 50 -
MIFEKRSTRTRLAFE OTCA_THEMA 51 51 -
LLFEKTSTRTRCAFE OTCC_CLOPE 51 51 -
IIFEKDSTRTRCAFE O51782 51 51 -
LIFEKTSTRTRCAFE OTCC_NEIGO 49 49 -
LIFEKTSTRTRCAFE OTCC_RHIET 51 51 -
LIFEKTSTRTRCAFE OTCC_HAEIN 51 51 -
LIFEKTSTRTRCAFE OTCC_PSEAE 50 50 -
VIFDKNSTRTRFSFE OTCA_MYCBO 44 44 -
VIFDKNSTRTRFSFE OTCA_MYCTU 44 44 -
MIFEKSSTRTRLSFE OTCA_PSESH 47 47 -
ILFEKPSTRTRMSFD OTC_METJA 42 42 -
MMFSKRSTRTRISTE OTC_ASPTE 83 83 -
MIFSKRSTRTRVSTE OTC_EMENI 81 81 -
MVFEKASTRTRLSFE OTCA_PSEAE 46 46 -
MIFEKSSTRTRVSFE OTCA_BACSU 51 51 -
MIFEKRSTRTRLSTE OTC_RANCA 80 80 -
LLFEKNSTRTRAAFT O53089 52 52 -
MIFEKRSTRTRLSTE OTC_HUMAN 84 84 -
MMFSKRSTRTRISTE OTC_ASPNG 91 91 -
MIFEKRSTRTRLSTE OTC_MOUSE 84 84 -
MIFEKRSTRTRLSTE OTC_RAT 84 84 -
MIFSKRSTRTRVSVE OTC_SCHPO 57 57 -
LLFSKASTRTRVSFT O87319 45 45 -
MIFAKPSMRTRVSFE OTC_PEA 117 117 -
MIFAKPSMRTRVSFE OTC_ARATH 117 117 -
LLFYKASTRTRVSFT OTCA_SYNY3 47 47 -
LLFEKTSTRTRSAFT OTCA_LACPL 51 51 -
LIFTKRSTRTRISTE OTC_YEAST 61 61 -
LLFTKPSTRTRVSFE O67607 44 44 -
MLFAKPSTRTRLSFE OTC_HALSA 43 43 -
LIFNKRSTRTRVSSE OTC_PACTA 78 78 -
GIFLKPSGRTSTSFV OTCC_PSESH 52 52 -
LLFSKRSTRTRLSAE OTC_CORHI 72 72 -
TIYEKPSLRTRVTFD OTCA_VIBS2 43 43 -
AFFAKPSLRTRVSLE O76458 48 48 -

Motif 2 width=14
Element Seqn Id St Int Rpt
QIGHKESIKDTARV OTC1_ECOLI 82 18 -
QIGHKESIKDTARV OTC2_ECOLI 82 18 -
QLGRGEPIKDTARV OTC_ARCFU 78 18 -
QLGRGEPIADTART OTC_METTH 73 18 -
QLGKKESIEDTAKV O86132 86 18 -
QLRRGETIADTARV O58457 84 18 -
QLRRGETIADTARV OTC_PYRFU 84 18 -
QIGVKESMKDTARV O51897 83 18 -
HLGAKESLEDTARV OTCA_THEMA 84 18 -
QMGKKESIEDTAKV OTCC_CLOPE 82 16 -
QMGSKESMIDTARV O51782 84 18 -
QIGHKESIKDTARV OTCC_NEIGO 82 18 -
QIGHKESFKDTARV OTCC_RHIET 84 18 -
QIGHKESMKDTARV OTCC_HAEIN 84 18 -
QIGHKESMKDTARV OTCC_PSEAE 83 18 -
QLGRDETLQDTAKV OTCA_MYCBO 77 18 -
QLGRDETLQDTAKV OTCA_MYCTU 77 18 -
QLGRGEPIADSAKV OTCA_PSESH 80 18 -
HLGKKESIKDTAKV OTC_METJA 75 18 -
QLGVNESLYDTAVV OTC_ASPTE 116 18 -
QLGVNESLYDTSVV OTC_EMENI 114 18 -
QLGRGEPIGDSARV OTCA_PSEAE 79 18 -
QLGRGETVADTAKV OTCA_BACSU 84 18 -
HLGVNESLKDTARV OTC_RANCA 113 18 -
QLGKKESVEDTAKV O53089 85 18 -
HLGVNESLTDTARV OTC_HUMAN 117 18 -
QLGVNESLYDTAVV OTC_ASPNG 124 18 -
HLGVNESLTDTARV OTC_MOUSE 117 18 -
HLGVNESLTDTARV OTC_RAT 117 18 -
QLGVNESLYDTSKV OTC_SCHPO 90 18 -
QVSRGEPLQDTARV O87319 78 18 -
QMGKREETRDVARV OTC_PEA 150 18 -
QMGKREETPDVARV OTC_ARATH 150 18 -
QVGRGEPIQDTARV OTCA_SYNY3 80 18 -
QFGTKESVVDTAKV OTCA_LACPL 84 18 -
QLGVNESFYDTTKV OTC_YEAST 94 18 -
QVSRGEDVRDTART O67607 77 18 -
QLSRGEPISDVSQV OTC_HALSA 76 18 -
QLGVNESLHDTTKI OTC_PACTA 111 18 -
RFGHKESIKDFARV OTCC_PSESH 85 18 -
QLGVNETVPDSARV OTC_CORHI 105 18 -
AIGERETVKDFAAN OTCA_VIBS2 76 18 -
NVGGKETVQDTAEV O76458 82 19 -

Motif 3 width=15
Element Seqn Id St Int Rpt
VPVWNGLTNEFHPTQ OTC1_ECOLI 122 26 -
VPVWNGLTNEFHPTQ OTC2_ECOLI 122 26 -
VPVINGLSNLEHPCQ OTC_ARCFU 118 26 -
VPVINGLTDLEHPCQ OTC_METTH 113 26 -
VPVWNGLTDLWHPTQ O86132 126 26 -
VPVINGLSDFSHPCQ O58457 124 26 -
VPVINGLSDFSHPCQ OTC_PYRFU 124 26 -
VPVYNGLTDISHPTQ O51897 123 26 -
VPVYNGLTDEFHPTQ OTCA_THEMA 124 26 -
VPVWNGLTDADHPTQ OTCC_CLOPE 122 26 -
VPVYNGLTDISHPTQ O51782 124 26 -
VPVFNGLTNEFHPTQ OTCC_NEIGO 122 26 -
VPVYNGLTDEYHPTQ OTCC_RHIET 124 26 -
VPVFNGLTDEFHPTQ OTCC_HAEIN 124 26 -
VPVFNGLTDEYHPTQ OTCC_PSEAE 123 26 -
VPVINALSDEFHPCQ OTCA_MYCBO 117 26 -
VPVINALSDEFHPCQ OTCA_MYCTU 117 26 -
VPVINGLSDDLHPCQ OTCA_PSESH 120 26 -
VPVINALSDLAHPCQ OTC_METJA 115 26 -
VPVINALCDSFHPLQ OTC_ASPTE 156 26 -
VPVINALCDSFHPLQ OTC_EMENI 154 26 -
VPVINGLSDDLHPCQ OTCA_PSEAE 119 26 -
IPVINGLTDKYHPCQ OTCA_BACSU 124 26 -
IPIVNGLSDDYHPIQ OTC_RANCA 153 26 -
VPVWNGLTDEWHPTQ O53089 124 25 -
IPIINGLSDLYHPIQ OTC_HUMAN 157 26 -
KPVINALCDSYHPLQ OTC_ASPNG 164 26 -
IPIVNGLSDLYHPIQ OTC_MOUSE 157 26 -
IPIVNGLSDLYHPIQ OTC_RAT 157 26 -
CPVINGLCDTFHPLQ OTC_SCHPO 130 26 -
IPVINALTDAEHPCQ O87319 118 26 -
VPVINGLTDYNHPVQ OTC_PEA 190 26 -
VPVVNGLTDHNHPCQ OTC_ARATH 190 26 -
MPIINALSDLEHPCQ OTCA_SYNY3 120 26 -
VPVWNGLTDEWHPTQ OTCA_LACPL 124 26 -
VPIINSLCDKFHPLQ OTC_YEAST 134 26 -
VPVINALTNMSHPCQ O67607 117 26 -
VPVVNGLTDFLHPCQ OTC_HALSA 116 26 -
VPIINALCDTFHPLQ OTC_PACTA 151 26 -
IPVWNALTDTHHPTQ OTCC_PSESH 125 26 -
VPVLNALSSLWHPTQ OTC_CORHI 145 26 -
VPVVNSLCDLYHPCQ OTCA_VIBS2 116 26 -
VPCINALDDFGHPLQ O76458 122 26 -

Motif 4 width=11
Element Seqn Id St Int Rpt
IYTDVWVSMGE OTC1_ECOLI 228 91 -
IYTDVWVSMGE OTC2_ECOLI 228 91 -
IYTDVWTSMGQ OTC_ARCFU 217 84 -
VYTDVWVSMGY OTC_METTH 215 87 -
LYTDVWVSMGE O86132 230 89 -
IYTDVWASMGQ O58457 227 88 -
IYTDVWASMGQ OTC_PYRFU 226 87 -
VYTDVWVSMGE O51897 227 89 -
VYTDVWASMGE OTCA_THEMA 228 89 -
IYTDIWVSMGE OTCC_CLOPE 227 90 -
VYTDVWVSMGE O51782 228 89 -
IHTDVWVSMGE OTCC_NEIGO 227 90 -
IHTDVWVSMGE OTCC_RHIET 229 90 -
IHTDVWVSMGE OTCC_HAEIN 229 90 -
VHTDVWVSMGE OTCC_PSEAE 228 90 -
LVTDTWTSMGQ OTCA_MYCBO 221 89 -
LVTDTWTSMGQ OTCA_MYCTU 221 89 -
VSTDVWTSMGQ OTCA_PSESH 216 81 -
LYTDVWISMGD OTC_METJA 219 89 -
LVTDTWVSMGQ OTC_ASPTE 270 99 -
LVTDTWVSMGQ OTC_EMENI 268 99 -
VSTDVWASMGQ OTCA_PSEAE 215 81 -
IYSDVFTSMGQ OTCA_BACSU 227 88 -
LVTDTWVSMGQ OTC_RANCA 256 88 -
LYTDVWVSMGE O53089 228 89 -
LITDTWISMGR OTC_HUMAN 260 88 -
LVTDTWVSMGQ OTC_ASPNG 279 100 -
LITDTWISMGQ OTC_MOUSE 260 88 -
LITDTWISMGQ OTC_RAT 260 88 -
VVTDTWISMGQ OTC_SCHPO 233 88 -
LYTDVWASMGQ O87319 220 87 -
VYSDVWASMGQ OTC_PEA 290 85 -
VYSDVWASMGQ OTC_ARATH 290 85 -
LYTDVWASMGQ OTCA_SYNY3 222 87 -
LYTDVWVSMGE OTCA_LACPL 228 89 -
LVTDTFVSMGE OTC_YEAST 246 97 -
VYTDVWVSMGE O67607 221 89 -
VYGDVFVSMGE OTC_HALSA 210 79 -
IVTDTWISMGQ OTC_PACTA 255 89 -
IYTDVWISMGE OTCC_PSESH 229 89 -
VVTDTWISMGQ OTC_CORHI 273 113 -
IYGDTWVSMGD OTCA_VIBS2 218 87 -
VYTDSWMSYHI O76458 237 100 -

Motif 5 width=12
Element Seqn Id St Int Rpt
SIVFDQAENRMH OTC1_ECOLI 310 71 -
SIVFDQAENRMH OTC2_ECOLI 310 71 -
SIVFDQAENRLH OTC_ARCFU 279 51 -
SVVWDQAENRLH OTC_METTH 277 51 -
SKVFDEAENRMH O86132 310 69 -
SVVWDEAENRLH O58457 289 51 -
SVVWDQAENRLH OTC_PYRFU 288 51 -
SVVFDVAENRVH O51897 306 68 -
SRVWDEAENRKH OTCA_THEMA 291 52 -
SVVFDEAENRMH OTCC_CLOPE 308 70 -
SVVFDVAENRVH O51782 306 67 -
GIVFDQAENRMH OTCC_NEIGO 308 70 -
NVAFEQAENRLH OTCC_RHIET 311 71 -
NIAFEQAENRMH OTCC_HAEIN 312 72 -
NIAFEQAENRMH OTCC_PSEAE 311 72 -
SAVWDEAENRLH OTCA_MYCBO 283 51 -
SAVWDEAENRLH OTCA_MYCTU 283 51 -
SVAWDQAENRLH OTCA_PSESH 278 51 -
SVVYDEAENRLH OTC_METJA 281 51 -
SLVFPEAENRLW OTC_ASPTE 333 52 -
SLVFPEAENRLW OTC_EMENI 331 52 -
SVAWDQAENRLH OTCA_PSEAE 277 51 -
SAVFQQAENRLH OTCA_BACSU 289 51 -
SLVFQEAENRKW OTC_RANCA 317 50 -
ARQFEEAENRMH O53089 308 69 -
SLVFPEAENRKW OTC_HUMAN 321 50 -
SLVFPEAENRLW OTC_ASPNG 342 52 -
SLVFPEAENRKW OTC_MOUSE 321 50 -
SLVFPEAENRKW OTC_RAT 321 50 -
SLVFQEAENRKW OTC_SCHPO 294 50 -
SRVWEQAENRLH O87319 282 51 -
SIVFPQAENRMH OTC_PEA 352 51 -
SIVFPQAENRMH OTC_ARATH 352 51 -
SRLWDQAENRMH OTCA_SYNY3 284 51 -
AVVFEEAGNRMP OTCA_LACPL 308 69 -
SIVFEEAENRLY OTC_YEAST 307 50 -
DFIFTQAENRLH O67607 280 48 -
SVIFDQAENRMH OTC_HALSA 272 51 -
SLVFEEGENRLY OTC_PACTA 319 53 -
SRVFDQGENRMH OTCC_PSESH 304 64 -
SLVFQESDNRKW OTC_CORHI 336 52 -
SLIFDQAENRMH OTCA_VIBS2 279 50 -
SVCYDEAGNRLH O76458 300 52 -