| Identifier | HAEMOXYGNASE [View Relations] [View Alignment]
|
| Accession | PR00088 |
| No. of Motifs | 7 |
| Creation Date | 05-MAR-1995 (UPDATE 26-JUN-1999) |
| Title | Haem oxygenase signature |
| Database References |
PROSITE; PS00593 HEME_OXYGENASE
BLOCKS; BL00593
PFAM; PF01126 Heme
INTERPRO; IPR002051
|
| Literature References | 1. MUELLER, R.M., TAGUCHI, H. AND SHIBAHARA, S.
Nucleotide sequence and organization of the rat heme oxygenase gene.
J.BIOL.CHEM. 262 6795-6802 (1987).
2. CRUSE, I. AND MAINES, M.D.
Evidence suggesting that the two forms of heme oxygenase are products of
different genes.
J.BIOL.CHEM. 263 3348-3353 (1988).
|
| Documentation | Haem oxygenase is an essential enzyme in haem catabolism, catalysing the
oxidative cleavage of the haem ring at the alpha methene bridge, yielding
biliverdin and carbon monoxide [1]. This microsomal enzyme is induced by
its substrate haem, heavy metal atoms, and various other factors [1].
Mammals possess 2 oxygenase isozymes (HO1 and HO2), which show a high
degree of sequence similarity [2]: unlike HO1, however, HO2 is not
inducible by haem and other factors [1,2]. It is believed that HO2 may
be active in the brain, producing carbon monoxide, which is said to act
as a neurotransmitter [2].
HAEMOXYGNASE is a 7-element fingerprint that provides a signature for haem
oxygenases. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motif 4 including the active centre region
encoded by PROSITE pattern HEME_OXYGENASE (PS00593), the His of which is
thought to bind the haem. Two iterations on OWL25.1 were required to reach
convergence, at which point a true set comprising 9 sequences was
identified.
An update on SPTR37_9f identified a true set of 15 sequences, and 2
partial matches.
|
| Summary Information | 15 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
2 codes involving 3 elements
0 codes involving 2 elements
|
| Composite Feature Index | | 7 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 3 | 2 | 0 | 0 | 1 | 0 | 1 | 2 | | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|
| True Positives | HO1_HUMAN HO1_MOUSE HO1_PIG HO1_RAT
HO1_SYNY3 HO2_HUMAN HO2_MOUSE HO2_RABIT
HO2_RAT HO2_SYNY3 HO_CHICK HO_FUGRU
HO_GUITH HO_PORPU HO_RHOVL |
| True Positive Partials | |
| Sequence Titles | HO1_HUMAN HEME OXYGENASE 1 (EC 1.14.99.3) (HO-1) - HOMO SAPIENS (HUMAN).
HO1_MOUSE HEME OXYGENASE 1 (EC 1.14.99.3) (HO-1) (P32 PROTEIN) - MUS MUSCULUS (MOUSE).
HO1_PIG HEME OXYGENASE 1 (EC 1.14.99.3) (HO-1) - SUS SCROFA (PIG).
HO1_RAT HEME OXYGENASE 1 (EC 1.14.99.3) (HO-1) - RATTUS NORVEGICUS (RAT).
HO1_SYNY3 HEME OXYGENASE 1 (EC 1.14.99.3) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
HO2_HUMAN HEME OXYGENASE 2 (EC 1.14.99.3) (HO-2) - HOMO SAPIENS (HUMAN).
HO2_MOUSE HEME OXYGENASE 2 (EC 1.14.99.3) (HO-2) - MUS MUSCULUS (MOUSE).
HO2_RABIT HEME OXYGENASE 2 (EC 1.14.99.3) (HO-2) - ORYCTOLAGUS CUNICULUS (RABBIT).
HO2_RAT HEME OXYGENASE 2 (EC 1.14.99.3) (HO-2) - RATTUS NORVEGICUS (RAT).
HO2_SYNY3 HEME OXYGENASE 2 (EC 1.14.99.3) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
HO_CHICK HEME OXYGENASE (EC 1.14.99.3) (HO) - GALLUS GALLUS (CHICKEN).
HO_FUGRU HEME OXYGENASE (EC 1.14.99.3) (HO) - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
HO_GUITH HEME OXYGENASE (EC 1.14.99.3) - GUILLARDIA THETA (CRYPTOMONAS PHI).
HO_PORPU HEME OXYGENASE (EC 1.14.99.3) - PORPHYRA PURPUREA.
HO_RHOVL HEME OXYGENASE (EC 1.14.99.3) - RHODELLA VIOLACEA.
HMUO_CORDI HEME OXYGENASE (EC 1.14.99.3) - CORYNEBACTERIUM DIPHTHERIAE.
HO3_RAT HEME OXYGENASE 3 (EC 1.14.99.3) (HO-3) - RATTUS NORVEGICUS (RAT).
|
| Scan History | OWL25_1 2 100 NSINGLE
SPTR37_9f 3 18 NSINGLE
|
| Initial Motifs | Motif 1 width=26
Element Seqn Id St Int Rpt
DLSELLKEGTKEAHDRAENTQFVKDF HO2_HUMAN 32 32 -
DLSELLKEGTKEAHDRAENTQFVKDF HO2_RAT 31 31 -
DLSELLKEATKEVHEQAENTPFMKNF HO_CHICK 15 15 -
DLSEALKEATKEVHTQAENAEFMRNF HO1_HUMAN 12 12 -
DLSEALKEATKEVHIRAENSEFMRNF HO1_RAT 12 12 -
DLSEALKEATKEVHVQAENAEFMKNF HO1_PIG 12 12 -
Motif 2 width=26
Element Seqn Id St Int Rpt
FKLATTALYFTYSALEEEMDRNKDHP HO2_HUMAN 67 9 -
FKLATTALYFTYSALEEEMDRNKDHP HO2_RAT 66 9 -
FKLVTASLYFIYSALEEEIERNKDNP HO_CHICK 50 9 -
FKLVMASLYHIYVALEEEIERNKESP HO1_HUMAN 47 9 -
FKLVMASLYHIYTALEEEIERNKQNP HO1_RAT 47 9 -
FKLVMASLYHIYDALEEEIEHNKENP HO1_PIG 47 9 -
Motif 3 width=26
Element Seqn Id St Int Rpt
AFAPLYFPMELHRKEALTKDMEYFFG HO2_HUMAN 93 0 -
AFAPLYFPTELHRKEALIKDMEYFFG HO2_RAT 92 0 -
VYAPVYFPMELHRKAALEKDLEYFYG HO_CHICK 76 0 -
VFAPVYFPEELHRKAALEQDLAFWYG HO1_HUMAN 73 0 -
VYAPLYFPEELHRRAALEQDMAFWYG HO1_RAT 73 0 -
VYTPLYFPEELHRRAALEQDMAFWYG HO1_PIG 73 0 -
Motif 4 width=22
Element Seqn Id St Int Rpt
PELLVAHAYTRYMGDLSGGQVL HO2_HUMAN 146 27 -
PELLVAHAYTRYMGDLSGGQVL HO2_RAT 145 27 -
PELLVAHAYTRYLGDLSGGQVL HO_CHICK 129 27 -
PELLVAHAYTRYLGDLSGGQVL HO1_HUMAN 126 27 -
PELLVAHAYTRYLGDLSGGQVL HO1_RAT 126 27 -
PELLVAHAYTRYMGDLSGGQVL HO1_PIG 126 27 -
Motif 5 width=22
Element Seqn Id St Int Rpt
KKVAQRALKLPSTGEGTQFYLF HO2_HUMAN 168 0 -
KKVAQRALKLPSTGEGTQFYLF HO2_RAT 167 0 -
KKIAQKALQLPSTGEGLAFFTF HO_CHICK 151 0 -
KKIAQKALDLPSSGEGLAFFTF HO1_HUMAN 148 0 -
KKIAQKAMALPSSGEGLAFFTF HO1_RAT 148 0 -
KKIAQKALDLPSSGEGLAFFTF HO1_PIG 148 0 -
Motif 6 width=22
Element Seqn Id St Int Rpt
ENVDNAQQFKQLYRARMNALDL HO2_HUMAN 190 0 -
EHVDNAQQFKQFYRARMNALDL HO2_RAT 189 0 -
DGVSNATKFKQLYRSRMNALEM HO_CHICK 173 0 -
PNIASATKFKQLYRSRMNSLEM HO1_HUMAN 170 0 -
PSIDNPTKFKQLYRARMNTLEM HO1_RAT 170 0 -
PNVANATKFKQLYRSRMNTLEM HO1_PIG 170 0 -
Motif 7 width=19
Element Seqn Id St Int Rpt
EANKAFEYNMQIFNELDQA HO2_HUMAN 221 9 -
EANKAFEYNMQIFSELDQA HO2_RAT 221 10 -
EAKKAFLLNIQVFEALQKL HO_CHICK 205 10 -
EAKTAFLLNIQLFEELQEL HO1_HUMAN 202 10 -
EAKTAFLLNIELFEELQAL HO1_RAT 202 10 -
EAKTAFLLNIQLFEEVQEL HO1_PIG 202 10 -
|
| Final Motifs | Motif 1 width=26
Element Seqn Id St Int Rpt
DLSELLKEGTKEAHDRAENTQFVKDF HO2_HUMAN 32 32 -
DLSELLKEGTKEAHDRAENTKFVKDF HO2_RABIT 28 28 -
DLSELLKEGTKEAHDRAENTQFVKDF HO2_RAT 31 31 -
DLSELLKEATKEVHEQAENTPFMKNF HO_CHICK 15 15 -
DLSELLKEGTKEAHDRAENTQFVKDF HO2_MOUSE 31 31 -
DLSEALKEATKEVHTQAENAEFMRNF HO1_HUMAN 12 12 -
DLSEALKEATKEVHIQAENAEFMKNF HO1_MOUSE 12 12 -
DLSEALKEATKEVHIRAENSEFMRNF HO1_RAT 12 12 -
DLSEALKEATKEVHVQAENAEFMKNF HO1_PIG 12 12 -
NLASQLREGTKKSHSMAENVGFVKCF HO1_SYNY3 4 4 -
SLANELREGTTKSHSMAENVSFVKSF HO_PORPU 4 4 -
DLSEQIKKVTKDVHVRAESTELMLSF HO_FUGRU 16 16 -
NLAIQLREGTSKSHSMAENVSFVKSF HO_GUITH 4 4 -
NLALQLRQGTTKAHSMAENVSFVKSF HO_RHOVL 6 6 -
NLAQKLRYGTQQSHTLAENTAYMKCF HO2_SYNY3 3 3 -
Motif 2 width=26
Element Seqn Id St Int Rpt
FKLATTALYFTYSALEEEMDRNKDHP HO2_HUMAN 67 9 -
FKLATTALYFTYSALEEEMDRNKDHP HO2_RABIT 63 9 -
FKLATTALYFTYSALEEEMDRNKDHP HO2_RAT 66 9 -
FKLVTASLYFIYSALEEEIERNKDNP HO_CHICK 50 9 -
FKLATTALYFTYSALEEEMDRNKDHP HO2_MOUSE 66 9 -
FKLVMASLYHIYVALEEEIERNKESP HO1_HUMAN 47 9 -
FKLVMASLYHIYTALEEEIERNKQNP HO1_MOUSE 47 9 -
FKLVMASLYHIYTALEEEIERNKQNP HO1_RAT 47 9 -
FKLVMASLYHIYDALEEEIEHNKENP HO1_PIG 47 9 -
YRKLVGNLYFVYSAMEEEMAKFKDHP HO1_SYNY3 39 9 -
YRKLIANLYFVYSAIEEEILLNKDHP HO_PORPU 39 9 -
YKLLLCSLYEIYLALEEEMDRNCDHP HO_FUGRU 51 9 -
YKKMMSNLYFVYKAMEEEMEYHKEND HO_GUITH 39 9 -
YRQLIANFYFVYSAIEDEMKRHQESQ HO_RHOVL 41 9 -
FRQLLANLYYLYSALEAALRQHRDNE HO2_SYNY3 38 9 -
Motif 3 width=26
Element Seqn Id St Int Rpt
AFAPLYFPMELHRKEALTKDMEYFFG HO2_HUMAN 93 0 -
AFAPLYFPMELHRKEALTKDMEYFFG HO2_RABIT 89 0 -
AFAPLYFPTELHRKEALIKDMEYFFG HO2_RAT 92 0 -
VYAPVYFPMELHRKAALEKDLEYFYG HO_CHICK 76 0 -
AFAPLYFPTELHRKAALIKDMKYFFG HO2_MOUSE 92 0 -
VFAPVYFPEELHRKAALEQDLAFWYG HO1_HUMAN 73 0 -
VYAPLYFPEELHRRAALEQDMAFWYG HO1_MOUSE 73 0 -
VYAPLYFPEELHRRAALEQDMAFWYG HO1_RAT 73 0 -
VYTPLYFPEELHRRAALEQDMAFWYG HO1_PIG 73 0 -
PILSHIYFPELNRKQSLEQDLQFYYG HO1_SYNY3 64 -1 -
PAIKPIYFTELNRKTSLAKDLNYYYG HO_PORPU 64 -1 -
SVAPIYFPAELARLATIEKDLEFFFG HO_FUGRU 77 0 -
DLIKPIYFVELNRSESLALDLNFYYG HO_GUITH 64 -1 -
QIIKPIYFEELNRKSSLEEDLQFYYG HO_RHOVL 66 -1 -
EIISAIYFPELNRTDKLAEDLTYYYG HO2_SYNY3 63 -1 -
Motif 4 width=22
Element Seqn Id St Int Rpt
PELLVAHAYTRYMGDLSGGQVL HO2_HUMAN 146 27 -
PELLVAHAYTRYMGDLSGGQVL HO2_RABIT 142 27 -
PELLVAHAYTRYMGDLSGGQVL HO2_RAT 145 27 -
PELLVAHAYTRYLGDLSGGQVL HO_CHICK 129 27 -
PELLVAHAYTRYMGDLSGGQVL HO2_MOUSE 145 27 -
PELLVAHAYTRYLGDLSGGQVL HO1_HUMAN 126 27 -
PELLVAHAYTRYLGDLSGGQVL HO1_MOUSE 126 27 -
PELLVAHAYTRYLGDLSGGQVL HO1_RAT 126 27 -
PELLVAHAYTRYMGDLSGGQVL HO1_PIG 126 27 -
PELLVAHSYTRYLGDLSGGQIL HO1_SYNY3 117 27 -
PELLVAHAYTRYLGDLSGGQVL HO_PORPU 117 27 -
PEYLIAHAYTRYLGDLSGGQVL HO_FUGRU 130 27 -
PLLLIAHAYTRYLGDLSGGQIL HO_GUITH 117 27 -
PELLIAHCYTRYLGDLSGGQIL HO_RHOVL 119 27 -
PELLIAHCYTRYLGDLSGGQSL HO2_SYNY3 116 27 -
Motif 5 width=22
Element Seqn Id St Int Rpt
KKVAQRALKLPSTGEGTQFYLF HO2_HUMAN 168 0 -
KKVAQRALKLPSTGEGTQFYLF HO2_RABIT 164 0 -
KKVAQRALKLPSTGEGTQFYLF HO2_RAT 167 0 -
KKIAQKALQLPSTGEGLAFFTF HO_CHICK 151 0 -
KKVAQRALKLPSTGEGTQFYLF HO2_MOUSE 167 0 -
KKIAQKALDLPSSGEGLAFFTF HO1_HUMAN 148 0 -
KKIAQKAMALPSSGEGLAFFTF HO1_MOUSE 148 0 -
KKIAQKAMALPSSGEGLAFFTF HO1_RAT 148 0 -
KKIAQKALDLPSSGEGLAFFTF HO1_PIG 148 0 -
KKIAQNAMNLHDGGTAFYEFAD HO1_SYNY3 139 0 -
KKIARGAMNLSDERGTKFYDFD HO_PORPU 139 0 -
GRIAQKSMKLGGSEGLSFFAFP HO_FUGRU 152 0 -
KKIAQRALNVPNSQGLAFYEFD HO_GUITH 139 0 -
LKKITQSAMNLSGGEGTAFYEF HO_RHOVL 140 -1 -
LKNIIRSALQLPEGEGTAMYEF HO2_SYNY3 137 -1 -
Motif 6 width=22
Element Seqn Id St Int Rpt
ENVDNAQQFKQLYRARMNALDL HO2_HUMAN 190 0 -
ENVDNAQQFKQFYRARMNALDL HO2_RABIT 186 0 -
EHVDNAQQFKQFYRARMNALDL HO2_RAT 189 0 -
DGVSNATKFKQLYRSRMNALEM HO_CHICK 173 0 -
EHVDNAQQFKQFYRARMNALDL HO2_MOUSE 189 0 -
PNIASATKFKQLYRSRMNSLEM HO1_HUMAN 170 0 -
PNIDSPTKFKQLYRARMNTLEM HO1_MOUSE 170 0 -
PSIDNPTKFKQLYRARMNTLEM HO1_RAT 170 0 -
PNVANATKFKQLYRSRMNTLEM HO1_PIG 170 0 -
ADIDDEKAFKNTYRQAMNDLPI HO1_SYNY3 159 -2 -
DEIEDDKIFKNNYRSALDTIPL HO_PORPU 160 -1 -
PGVSSPNLFKRLYRSRMNSVEL HO_FUGRU 173 -1 -
DKIDDEQAFKQKYKKALDTLPV HO_GUITH 160 -1 -
KDIKDEKNFKQNYRLALDSIHL HO_RHOVL 162 0 -
PTPGDRRQFKEIYRDVLNSLPL HO2_SYNY3 162 3 -
Motif 7 width=19
Element Seqn Id St Int Rpt
EANKAFEYNMQIFNELDQA HO2_HUMAN 221 9 -
EANKAFEYNMQIFSELDQA HO2_RABIT 218 10 -
EANKAFEYNMQIFSELDQA HO2_RAT 221 10 -
EAKKAFLLNIQVFEALQKL HO_CHICK 205 10 -
EANKAFEYNMQIFSELDQA HO2_MOUSE 221 10 -
EAKTAFLLNIQLFEELQEL HO1_HUMAN 202 10 -
EAKTAFLLNIELFEELQVM HO1_MOUSE 202 10 -
EAKTAFLLNIELFEELQAL HO1_RAT 202 10 -
EAKTAFLLNIQLFEEVQEL HO1_PIG 202 10 -
EANDAFAMNMKMFNELEGN HO1_SYNY3 191 10 -
EANISFTLNMKMFEELNSS HO_PORPU 192 10 -
EALGAFEFNIQVFEDLQKM HO_FUGRU 205 10 -
EANIAFNLNMRMFQELEMS HO_GUITH 192 10 -
EANIAFKLNMKIFQELNSN HO_RHOVL 194 10 -
EANYAFSLNREVMHDLEDL HO2_SYNY3 194 10 -
|