Identifier | HAEMOXYGNASE  [View Relations]  [View Alignment]  
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Accession | PR00088 |
No. of Motifs | 7 |
Creation Date | 05-MAR-1995  (UPDATE 26-JUN-1999) |
Title | Haem oxygenase signature |
Database References | PROSITE; PS00593 HEME_OXYGENASE BLOCKS; BL00593 PFAM; PF01126 Heme INTERPRO; IPR002051
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Literature References | 1. MUELLER, R.M., TAGUCHI, H. AND SHIBAHARA, S.
Nucleotide sequence and organization of the rat heme oxygenase gene.
J.BIOL.CHEM. 262 6795-6802 (1987).
2. CRUSE, I. AND MAINES, M.D.
Evidence suggesting that the two forms of heme oxygenase are products of
different genes.
J.BIOL.CHEM. 263 3348-3353 (1988).
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Documentation | Haem oxygenase is an essential enzyme in haem catabolism, catalysing the
oxidative cleavage of the haem ring at the alpha methene bridge, yielding
biliverdin and carbon monoxide [1]. This microsomal enzyme is induced by
its substrate haem, heavy metal atoms, and various other factors [1].
Mammals possess 2 oxygenase isozymes (HO1 and HO2), which show a high
degree of sequence similarity [2]: unlike HO1, however, HO2 is not
inducible by haem and other factors [1,2]. It is believed that HO2 may
be active in the brain, producing carbon monoxide, which is said to act
as a neurotransmitter [2].
HAEMOXYGNASE is a 7-element fingerprint that provides a signature for haem
oxygenases. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motif 4 including the active centre region
encoded by PROSITE pattern HEME_OXYGENASE (PS00593), the His of which is
thought to bind the haem. Two iterations on OWL25.1 were required to reach
convergence, at which point a true set comprising 9 sequences was
identified.
An update on SPTR37_9f identified a true set of 15 sequences, and 2
partial matches.
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Summary Information | 15 codes involving 7 elements 0 codes involving 6 elements 0 codes involving 5 elements 0 codes involving 4 elements 2 codes involving 3 elements 0 codes involving 2 elements
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Composite Feature Index | 7 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
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True Positives | HO1_HUMAN HO1_MOUSE HO1_PIG HO1_RAT HO1_SYNY3 HO2_HUMAN HO2_MOUSE HO2_RABIT HO2_RAT HO2_SYNY3 HO_CHICK HO_FUGRU HO_GUITH HO_PORPU HO_RHOVL |
True Positive Partials | |
Sequence Titles | HO1_HUMAN HEME OXYGENASE 1 (EC 1.14.99.3) (HO-1) - HOMO SAPIENS (HUMAN). HO1_MOUSE HEME OXYGENASE 1 (EC 1.14.99.3) (HO-1) (P32 PROTEIN) - MUS MUSCULUS (MOUSE). HO1_PIG HEME OXYGENASE 1 (EC 1.14.99.3) (HO-1) - SUS SCROFA (PIG). HO1_RAT HEME OXYGENASE 1 (EC 1.14.99.3) (HO-1) - RATTUS NORVEGICUS (RAT). HO1_SYNY3 HEME OXYGENASE 1 (EC 1.14.99.3) - SYNECHOCYSTIS SP. (STRAIN PCC 6803). HO2_HUMAN HEME OXYGENASE 2 (EC 1.14.99.3) (HO-2) - HOMO SAPIENS (HUMAN). HO2_MOUSE HEME OXYGENASE 2 (EC 1.14.99.3) (HO-2) - MUS MUSCULUS (MOUSE). HO2_RABIT HEME OXYGENASE 2 (EC 1.14.99.3) (HO-2) - ORYCTOLAGUS CUNICULUS (RABBIT). HO2_RAT HEME OXYGENASE 2 (EC 1.14.99.3) (HO-2) - RATTUS NORVEGICUS (RAT). HO2_SYNY3 HEME OXYGENASE 2 (EC 1.14.99.3) - SYNECHOCYSTIS SP. (STRAIN PCC 6803). HO_CHICK HEME OXYGENASE (EC 1.14.99.3) (HO) - GALLUS GALLUS (CHICKEN). HO_FUGRU HEME OXYGENASE (EC 1.14.99.3) (HO) - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES). HO_GUITH HEME OXYGENASE (EC 1.14.99.3) - GUILLARDIA THETA (CRYPTOMONAS PHI). HO_PORPU HEME OXYGENASE (EC 1.14.99.3) - PORPHYRA PURPUREA. HO_RHOVL HEME OXYGENASE (EC 1.14.99.3) - RHODELLA VIOLACEA. HMUO_CORDI HEME OXYGENASE (EC 1.14.99.3) - CORYNEBACTERIUM DIPHTHERIAE. HO3_RAT HEME OXYGENASE 3 (EC 1.14.99.3) (HO-3) - RATTUS NORVEGICUS (RAT).
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Scan History | OWL25_1 2 100 NSINGLE SPTR37_9f 3 18 NSINGLE
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Initial Motifs | Motif 1 width=26 Element Seqn Id St Int Rpt DLSELLKEGTKEAHDRAENTQFVKDF HO2_HUMAN 32 32 - DLSELLKEGTKEAHDRAENTQFVKDF HO2_RAT 31 31 - DLSELLKEATKEVHEQAENTPFMKNF HO_CHICK 15 15 - DLSEALKEATKEVHTQAENAEFMRNF HO1_HUMAN 12 12 - DLSEALKEATKEVHIRAENSEFMRNF HO1_RAT 12 12 - DLSEALKEATKEVHVQAENAEFMKNF HO1_PIG 12 12 - Motif 2 width=26 Element Seqn Id St Int Rpt FKLATTALYFTYSALEEEMDRNKDHP HO2_HUMAN 67 9 - FKLATTALYFTYSALEEEMDRNKDHP HO2_RAT 66 9 - FKLVTASLYFIYSALEEEIERNKDNP HO_CHICK 50 9 - FKLVMASLYHIYVALEEEIERNKESP HO1_HUMAN 47 9 - FKLVMASLYHIYTALEEEIERNKQNP HO1_RAT 47 9 - FKLVMASLYHIYDALEEEIEHNKENP HO1_PIG 47 9 - Motif 3 width=26 Element Seqn Id St Int Rpt AFAPLYFPMELHRKEALTKDMEYFFG HO2_HUMAN 93 0 - AFAPLYFPTELHRKEALIKDMEYFFG HO2_RAT 92 0 - VYAPVYFPMELHRKAALEKDLEYFYG HO_CHICK 76 0 - VFAPVYFPEELHRKAALEQDLAFWYG HO1_HUMAN 73 0 - VYAPLYFPEELHRRAALEQDMAFWYG HO1_RAT 73 0 - VYTPLYFPEELHRRAALEQDMAFWYG HO1_PIG 73 0 - Motif 4 width=22 Element Seqn Id St Int Rpt PELLVAHAYTRYMGDLSGGQVL HO2_HUMAN 146 27 - PELLVAHAYTRYMGDLSGGQVL HO2_RAT 145 27 - PELLVAHAYTRYLGDLSGGQVL HO_CHICK 129 27 - PELLVAHAYTRYLGDLSGGQVL HO1_HUMAN 126 27 - PELLVAHAYTRYLGDLSGGQVL HO1_RAT 126 27 - PELLVAHAYTRYMGDLSGGQVL HO1_PIG 126 27 - Motif 5 width=22 Element Seqn Id St Int Rpt KKVAQRALKLPSTGEGTQFYLF HO2_HUMAN 168 0 - KKVAQRALKLPSTGEGTQFYLF HO2_RAT 167 0 - KKIAQKALQLPSTGEGLAFFTF HO_CHICK 151 0 - KKIAQKALDLPSSGEGLAFFTF HO1_HUMAN 148 0 - KKIAQKAMALPSSGEGLAFFTF HO1_RAT 148 0 - KKIAQKALDLPSSGEGLAFFTF HO1_PIG 148 0 - Motif 6 width=22 Element Seqn Id St Int Rpt ENVDNAQQFKQLYRARMNALDL HO2_HUMAN 190 0 - EHVDNAQQFKQFYRARMNALDL HO2_RAT 189 0 - DGVSNATKFKQLYRSRMNALEM HO_CHICK 173 0 - PNIASATKFKQLYRSRMNSLEM HO1_HUMAN 170 0 - PSIDNPTKFKQLYRARMNTLEM HO1_RAT 170 0 - PNVANATKFKQLYRSRMNTLEM HO1_PIG 170 0 - Motif 7 width=19 Element Seqn Id St Int Rpt EANKAFEYNMQIFNELDQA HO2_HUMAN 221 9 - EANKAFEYNMQIFSELDQA HO2_RAT 221 10 - EAKKAFLLNIQVFEALQKL HO_CHICK 205 10 - EAKTAFLLNIQLFEELQEL HO1_HUMAN 202 10 - EAKTAFLLNIELFEELQAL HO1_RAT 202 10 - EAKTAFLLNIQLFEEVQEL HO1_PIG 202 10 -
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Final Motifs | Motif 1 width=26 Element Seqn Id St Int Rpt DLSELLKEGTKEAHDRAENTQFVKDF HO2_HUMAN 32 32 - DLSELLKEGTKEAHDRAENTKFVKDF HO2_RABIT 28 28 - DLSELLKEGTKEAHDRAENTQFVKDF HO2_RAT 31 31 - DLSELLKEATKEVHEQAENTPFMKNF HO_CHICK 15 15 - DLSELLKEGTKEAHDRAENTQFVKDF HO2_MOUSE 31 31 - DLSEALKEATKEVHTQAENAEFMRNF HO1_HUMAN 12 12 - DLSEALKEATKEVHIQAENAEFMKNF HO1_MOUSE 12 12 - DLSEALKEATKEVHIRAENSEFMRNF HO1_RAT 12 12 - DLSEALKEATKEVHVQAENAEFMKNF HO1_PIG 12 12 - NLASQLREGTKKSHSMAENVGFVKCF HO1_SYNY3 4 4 - SLANELREGTTKSHSMAENVSFVKSF HO_PORPU 4 4 - DLSEQIKKVTKDVHVRAESTELMLSF HO_FUGRU 16 16 - NLAIQLREGTSKSHSMAENVSFVKSF HO_GUITH 4 4 - NLALQLRQGTTKAHSMAENVSFVKSF HO_RHOVL 6 6 - NLAQKLRYGTQQSHTLAENTAYMKCF HO2_SYNY3 3 3 - Motif 2 width=26 Element Seqn Id St Int Rpt FKLATTALYFTYSALEEEMDRNKDHP HO2_HUMAN 67 9 - FKLATTALYFTYSALEEEMDRNKDHP HO2_RABIT 63 9 - FKLATTALYFTYSALEEEMDRNKDHP HO2_RAT 66 9 - FKLVTASLYFIYSALEEEIERNKDNP HO_CHICK 50 9 - FKLATTALYFTYSALEEEMDRNKDHP HO2_MOUSE 66 9 - FKLVMASLYHIYVALEEEIERNKESP HO1_HUMAN 47 9 - FKLVMASLYHIYTALEEEIERNKQNP HO1_MOUSE 47 9 - FKLVMASLYHIYTALEEEIERNKQNP HO1_RAT 47 9 - FKLVMASLYHIYDALEEEIEHNKENP HO1_PIG 47 9 - YRKLVGNLYFVYSAMEEEMAKFKDHP HO1_SYNY3 39 9 - YRKLIANLYFVYSAIEEEILLNKDHP HO_PORPU 39 9 - YKLLLCSLYEIYLALEEEMDRNCDHP HO_FUGRU 51 9 - YKKMMSNLYFVYKAMEEEMEYHKEND HO_GUITH 39 9 - YRQLIANFYFVYSAIEDEMKRHQESQ HO_RHOVL 41 9 - FRQLLANLYYLYSALEAALRQHRDNE HO2_SYNY3 38 9 - Motif 3 width=26 Element Seqn Id St Int Rpt AFAPLYFPMELHRKEALTKDMEYFFG HO2_HUMAN 93 0 - AFAPLYFPMELHRKEALTKDMEYFFG HO2_RABIT 89 0 - AFAPLYFPTELHRKEALIKDMEYFFG HO2_RAT 92 0 - VYAPVYFPMELHRKAALEKDLEYFYG HO_CHICK 76 0 - AFAPLYFPTELHRKAALIKDMKYFFG HO2_MOUSE 92 0 - VFAPVYFPEELHRKAALEQDLAFWYG HO1_HUMAN 73 0 - VYAPLYFPEELHRRAALEQDMAFWYG HO1_MOUSE 73 0 - VYAPLYFPEELHRRAALEQDMAFWYG HO1_RAT 73 0 - VYTPLYFPEELHRRAALEQDMAFWYG HO1_PIG 73 0 - PILSHIYFPELNRKQSLEQDLQFYYG HO1_SYNY3 64 -1 - PAIKPIYFTELNRKTSLAKDLNYYYG HO_PORPU 64 -1 - SVAPIYFPAELARLATIEKDLEFFFG HO_FUGRU 77 0 - DLIKPIYFVELNRSESLALDLNFYYG HO_GUITH 64 -1 - QIIKPIYFEELNRKSSLEEDLQFYYG HO_RHOVL 66 -1 - EIISAIYFPELNRTDKLAEDLTYYYG HO2_SYNY3 63 -1 - Motif 4 width=22 Element Seqn Id St Int Rpt PELLVAHAYTRYMGDLSGGQVL HO2_HUMAN 146 27 - PELLVAHAYTRYMGDLSGGQVL HO2_RABIT 142 27 - PELLVAHAYTRYMGDLSGGQVL HO2_RAT 145 27 - PELLVAHAYTRYLGDLSGGQVL HO_CHICK 129 27 - PELLVAHAYTRYMGDLSGGQVL HO2_MOUSE 145 27 - PELLVAHAYTRYLGDLSGGQVL HO1_HUMAN 126 27 - PELLVAHAYTRYLGDLSGGQVL HO1_MOUSE 126 27 - PELLVAHAYTRYLGDLSGGQVL HO1_RAT 126 27 - PELLVAHAYTRYMGDLSGGQVL HO1_PIG 126 27 - PELLVAHSYTRYLGDLSGGQIL HO1_SYNY3 117 27 - PELLVAHAYTRYLGDLSGGQVL HO_PORPU 117 27 - PEYLIAHAYTRYLGDLSGGQVL HO_FUGRU 130 27 - PLLLIAHAYTRYLGDLSGGQIL HO_GUITH 117 27 - PELLIAHCYTRYLGDLSGGQIL HO_RHOVL 119 27 - PELLIAHCYTRYLGDLSGGQSL HO2_SYNY3 116 27 - Motif 5 width=22 Element Seqn Id St Int Rpt KKVAQRALKLPSTGEGTQFYLF HO2_HUMAN 168 0 - KKVAQRALKLPSTGEGTQFYLF HO2_RABIT 164 0 - KKVAQRALKLPSTGEGTQFYLF HO2_RAT 167 0 - KKIAQKALQLPSTGEGLAFFTF HO_CHICK 151 0 - KKVAQRALKLPSTGEGTQFYLF HO2_MOUSE 167 0 - KKIAQKALDLPSSGEGLAFFTF HO1_HUMAN 148 0 - KKIAQKAMALPSSGEGLAFFTF HO1_MOUSE 148 0 - KKIAQKAMALPSSGEGLAFFTF HO1_RAT 148 0 - KKIAQKALDLPSSGEGLAFFTF HO1_PIG 148 0 - KKIAQNAMNLHDGGTAFYEFAD HO1_SYNY3 139 0 - KKIARGAMNLSDERGTKFYDFD HO_PORPU 139 0 - GRIAQKSMKLGGSEGLSFFAFP HO_FUGRU 152 0 - KKIAQRALNVPNSQGLAFYEFD HO_GUITH 139 0 - LKKITQSAMNLSGGEGTAFYEF HO_RHOVL 140 -1 - LKNIIRSALQLPEGEGTAMYEF HO2_SYNY3 137 -1 - Motif 6 width=22 Element Seqn Id St Int Rpt ENVDNAQQFKQLYRARMNALDL HO2_HUMAN 190 0 - ENVDNAQQFKQFYRARMNALDL HO2_RABIT 186 0 - EHVDNAQQFKQFYRARMNALDL HO2_RAT 189 0 - DGVSNATKFKQLYRSRMNALEM HO_CHICK 173 0 - EHVDNAQQFKQFYRARMNALDL HO2_MOUSE 189 0 - PNIASATKFKQLYRSRMNSLEM HO1_HUMAN 170 0 - PNIDSPTKFKQLYRARMNTLEM HO1_MOUSE 170 0 - PSIDNPTKFKQLYRARMNTLEM HO1_RAT 170 0 - PNVANATKFKQLYRSRMNTLEM HO1_PIG 170 0 - ADIDDEKAFKNTYRQAMNDLPI HO1_SYNY3 159 -2 - DEIEDDKIFKNNYRSALDTIPL HO_PORPU 160 -1 - PGVSSPNLFKRLYRSRMNSVEL HO_FUGRU 173 -1 - DKIDDEQAFKQKYKKALDTLPV HO_GUITH 160 -1 - KDIKDEKNFKQNYRLALDSIHL HO_RHOVL 162 0 - PTPGDRRQFKEIYRDVLNSLPL HO2_SYNY3 162 3 - Motif 7 width=19 Element Seqn Id St Int Rpt EANKAFEYNMQIFNELDQA HO2_HUMAN 221 9 - EANKAFEYNMQIFSELDQA HO2_RABIT 218 10 - EANKAFEYNMQIFSELDQA HO2_RAT 221 10 - EAKKAFLLNIQVFEALQKL HO_CHICK 205 10 - EANKAFEYNMQIFSELDQA HO2_MOUSE 221 10 - EAKTAFLLNIQLFEELQEL HO1_HUMAN 202 10 - EAKTAFLLNIELFEELQVM HO1_MOUSE 202 10 - EAKTAFLLNIELFEELQAL HO1_RAT 202 10 - EAKTAFLLNIQLFEEVQEL HO1_PIG 202 10 - EANDAFAMNMKMFNELEGN HO1_SYNY3 191 10 - EANISFTLNMKMFEELNSS HO_PORPU 192 10 - EALGAFEFNIQVFEDLQKM HO_FUGRU 205 10 - EANIAFNLNMRMFQELEMS HO_GUITH 192 10 - EANIAFKLNMKIFQELNSN HO_RHOVL 194 10 - EANYAFSLNREVMHDLEDL HO2_SYNY3 194 10 -
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