| Literature References | 1. VICK, B.A. AND ZIMMERMAN, D.C.
In Biochemistry of plants: A comprehensive treatise.
STUMPF, P.K., ED., VOL.9, PP.53-90, ACADEMIC PRESS.
2. NEEDLEMAN, P., TURK, J., JAKSCHIK, B.A., MORRISON, A.R. AND
LEFKOWITH, J.B.
Arachidonic-acid metabolism.
ANNU.REV.BIOCHEMISTRY 55 69-102 (1986).
3. BOYINGTON J.C., GAFFNEY B.J. AND AMZEL L.M.
The 3-dimensional structure of an arachidonic-acid 15-lipoxygenase.
SCIENCE 260 1482-1486 (1993).
4. STECZKO, J., DONOHO, G.P., CLEMENS, J.C., DIXON, J.E. AND AXELROD, B.
Conserved histidine-residues in soybean lipoxygenase - Functional
consequences of their replacement.
BIOCHEMISTRY 31(16) 4053-4057 (1992).
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| Documentation | Lipoxygenases are iron-containing dioxygenases that catalyse the hydro-
peroxidation of lipids containing a cis,cis-1,4-pentadiene structure. They
are common in plants, where they are involved in such diverse aspects of
plant physiology as growth and development, pest resistance and senescence
or responses to wounding [1]. In mammals, a number of lipoxygenase isozymes
are involved in the metabolism of prostaglandins and leukotrienes [2].
The iron atom in lipoxygenases is bound by 4 ligands, 3 of which are
His residues [3]. In fact there are 6 histidines conserved in all lipoxy-
genases, 5 of which are clustered in a stretch of 40 amino acids. This
region contains 2 of the 3 His ligands: the other histidines are believed
to be important for lipoxygenase activity [4].
LIPOXYGENASE is a 3-element fingerprint that provides a signature for the
lipoxygenases. The fingerprint was derived from an initial alignment of
4 sequences: the motifs span conserved regions in the vicinity of the
clustered histidines - motif 2 includes the first 3 His residues and
corresponds to PROSITE pattern LIPOXYGENASE_1 (PS00711), while motif 3
includes the 4th and 5th His residues and corresponds to PROSITE pattern
LIPOXYGENASE_2 (PS00081). Two iterations on OWL22.0 were required to reach
convergence, at which point a true set comprising 25 sequences was
identified.
An update on SPTR37_9f identified a true set of 70 sequences, and 1
partial match.
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| Sequence Titles | LOX1_ARATH LIPOXYGENASE 1 (EC 1.13.11.12) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
LOX1_HORVU LIPOXYGENASE 1 (EC 1.13.11.12) - HORDEUM VULGARE (BARLEY).
LOX1_HUMAN ARACHIDONATE 15-LIPOXYGENASE (EC 1.13.11.33) (ARACHIDONATE OMEGA-6 LIPOXYGENASE) (15-LOX) - HOMO SAPIENS (HUMAN).
LOX1_LENCU LIPOXYGENASE (EC 1.13.11.12) - LENS CULINARIS (LENTIL).
LOX1_RABIT ARACHIDONATE 15-LIPOXYGENASE (EC 1.13.11.33) (OMEGA-6 LIPOXYGENASE) (ERYTHROID CELL-SPECIFIC 15-LIPOXYGENASE) (15-LOX) - ORYCTOLAGUS CUNICULUS (RABBIT).
LOX1_SOLTU LIPOXYGENASE 1 (EC 1.13.11.12) - SOLANUM TUBEROSUM (POTATO).
LOX1_SOYBN SEED LIPOXYGENASE-1 (EC 1.13.11.12) (L-1) - GLYCINE MAX (SOYBEAN).
LOX2_BOVIN ARACHIDONATE 12-LIPOXYGENASE (EC 1.13.11.31) (12-LOX) - BOS TAURUS (BOVINE).
LOX2_HUMAN ARACHIDONATE 12-LIPOXYGENASE (EC 1.13.11.31) (12-LOX) - HOMO SAPIENS (HUMAN).
LOX2_ORYSA LIPOXYGENASE L-2 (EC 1.13.11.12) - ORYZA SATIVA (RICE).
LOX2_PEA SEED LIPOXYGENASE-2 (EC 1.13.11.12) - PISUM SATIVUM (GARDEN PEA).
LOX2_PIG ARACHIDONATE 12-LIPOXYGENASE (EC 1.13.11.31) (12-LOX) - SUS SCROFA (PIG).
LOX2_RAT ARACHIDONATE 12-LIPOXYGENASE (EC 1.13.11.31) (12-LOX) - RATTUS NORVEGICUS (RAT).
LOX2_SOYBN SEED LIPOXYGENASE-2 (EC 1.13.11.12) (L-2) - GLYCINE MAX (SOYBEAN).
LOX3_PEA SEED LIPOXYGENASE-3 (EC 1.13.11.12) - PISUM SATIVUM (GARDEN PEA).
LOX3_SOYBN SEED LIPOXYGENASE-3 (EC 1.13.11.12) (L-3) - GLYCINE MAX (SOYBEAN).
LOX4_SOYBN LIPOXYGENASE-4 (EC 1.13.11.12) (L-4) (VSP94) - GLYCINE MAX (SOYBEAN).
LOX5_HUMAN ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO) - HOMO SAPIENS (HUMAN).
LOX5_MESAU ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
LOX5_MOUSE ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO) - MUS MUSCULUS (MOUSE).
LOX5_RAT ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO) - RATTUS NORVEGICUS (RAT).
LOXA_LYCES LIPOXYGENASE A (EC 1.13.11.12) - LYCOPERSICON ESCULENTUM (TOMATO).
LOXA_PHAVU LIPOXYGENASE 1 (EC 1.13.11.12) - PHASEOLUS VULGARIS (KIDNEY BEAN) (FRENCH BEAN).
LOXB_LYCES LIPOXYGENASE B (EC 1.13.11.12) - LYCOPERSICON ESCULENTUM (TOMATO).
LOXC_ARATH LIPOXYGENASE, CHLOROPLAST PRECURSOR (EC 1.13.11.12) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
LOXC_ORYSA LIPOXYGENASE, CHLOROPLAST PRECURSOR (EC 1.13.11.12) - ORYZA SATIVA (RICE).
LOXE_MOUSE ARACHIDONATE 12-LIPOXYGENASE, EPIDERMAL-TYPE (EC 1.13.11.31) (12-LOX) - MUS MUSCULUS (MOUSE).
LOXL_MOUSE ARACHIDONATE 12-LIPOXYGENASE, LEUKOCYTE-TYPE (EC 1.13.11.31) (12-LOX) - MUS MUSCULUS (MOUSE).
LOXP_MOUSE ARACHIDONATE 12-LIPOXYGENASE, PLATELET-TYPE (EC 1.13.11.31) (12-LOX) - MUS MUSCULUS (MOUSE).
LOXX_SOYBN SEED LIPOXYGENASE (EC 1.13.11.12) - GLYCINE MAX (SOYBEAN).
O04919 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - VICIA FABA (BROAD BEAN).
O15296 15S-LIPOXYGENASE - HOMO SAPIENS (HUMAN).
O16025 8R-LIPOXYGENASE-ALLENE OXIDE SYNTHASE FUSION PROTEIN - PLEXAURA HOMOMALLA.
O19043 12-LIPOXYGENASE - ORYCTOLAGUS CUNICULUS (RABBIT).
O22507 LIPOXYGENASE - SOLANUM TUBEROSUM (POTATO).
O22508 LIPOXYGENASE - SOLANUM TUBEROSUM (POTATO).
O24295 LIPOXYGENASE - PISUM SATIVUM (GARDEN PEA).
O24370 13-LIPOXYGENASE (EC 1.13.11.12) - SOLANUM TUBEROSUM (POTATO).
O24371 13-LIPOXYGENASE (EC 1.13.11.12) - SOLANUM TUBEROSUM (POTATO).
O24379 LIPOXYGENASE (EC 1.13.11.12) - SOLANUM TUBEROSUM (POTATO).
O24470 LIPOXYGENASE (EC 1.13.11.12) - PISUM SATIVUM (GARDEN PEA).
O35936 8S-LIPOXYGENASE - MUS MUSCULUS (MOUSE).
O49150 5-LIPOXYGENASE - SOLANUM TUBEROSUM (POTATO).
O49878 HAPLOTYPE OF THE CF-4/9 RESISTANCE GENE LOCUS - LYCOPERSICON ESCULENTUM (TOMATO).
O70582 ARACHIDONATE 12-LIPOXYGENASE, PSEUDOGENE 2 (EPIDERMIS-TYPE LIPOXYGENASE 2) - MUS MUSCULUS (MOUSE).
O75342 12R-LIPOXYGENASE - HOMO SAPIENS (HUMAN).
O81401 NBS/LRR DISEASE RESISTANCE PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P93184 LIPOXYGENASE, CHLOROPLAST PRECURSOR (EC 1.13.11.12) (LOX-100) - HORDEUM VULGARE (BARLEY).
P93698 CPRD46 PROTEIN - VIGNA UNGUICULATA (COWPEA).
Q39838 SEED LIPOXYGENASE-3 (EC 1.13.11.12) (L-3) - GLYCINE MAX (SOYBEAN).
Q39870 LIPOXYGENASE-2 - GLYCINE MAX (SOYBEAN).
Q41244 LIPOXYGENASE - GLYCINE MAX (SOYBEAN).
Q41430 LIPOXYGENASE - SOLANUM TUBEROSUM (POTATO).
Q42704 LIPOXYGENASE 1 (EC 1.13.11.12) - CUCUMIS SATIVUS (CUCUMBER).
Q42705 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - CUCUMIS SATIVUS (CUCUMBER).
Q42710 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - CUCUMIS SATIVUS (CUCUMBER).
Q42780 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - GLYCINE MAX (SOYBEAN).
Q42846 LIPOXYGENASE (EC 1.13.11.12) - HORDEUM VULGARE (BARLEY).
Q42847 LIPOXYGENASE 2 (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - HORDEUM VULGARE (BARLEY).
Q42873 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
Q43189 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - SOLANUM TUBEROSUM (POTATO).
Q43190 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - SOLANUM TUBEROSUM (POTATO).
Q43191 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - SOLANUM TUBEROSUM (POTATO).
Q43438 LIPOXYGENASE - GLYCINE MAX (SOYBEAN).
Q43440 LIPOXYGENASE - GLYCINE MAX (SOYBEAN).
Q43446 LIPOXYGENASE L-5 - GLYCINE MAX (SOYBEAN).
Q43800 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - NICOTIANA TABACUM (COMMON TOBACCO).
Q43817 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - PISUM SATIVUM (GARDEN PEA).
Q96573 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
Q96574 LIPOXYGENASE (EC 1.13.11.12) (LIPOXIDASE) (CAROTENE OXIDASE) - LYCOPERSICON ESCULENTUM (TOMATO).
Q27901 8(R)-LIPOXYGENASE - PLEXAURA HOMOMALLA.
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