Identifier | THFDHDRGNASE  [View Relations]  [View Alignment]  
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Accession | PR00085 |
No. of Motifs | 7 |
Creation Date | 01-MAR-1995  (UPDATE 07-JUN-1999) |
Title | Tetrahydrofolate dehydrogenase/cyclohydrolase family signature |
Database References | PROSITE; PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2 BLOCKS; BL00766 PFAM; PF00763 THF_DHG_CYH INTERPRO; IPR000672
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Literature References | 1. PRICE, B.D. AND LAUGHTON, A.
The isolation and characterization of a Drosophila gene encoding a
putative NAD-depenedent methylenetetrahydrofolate dehydrogenase-
methenyltetrahydrofolate cyclohydrolase.
BIOCHIM.BIOPHYS.ACTA 1173 94-98 (1993).
2. BARLOWE, C.K., WILLIAMS, M.E., RABINOWITZ, J.C. AND APPLING, D.R.
Site-directed mutagenesis of yeast C1-tetrahydrofolate synthase: analysis
of an overlapping active site in a multifunctional enzyme.
BIOCHEMISTRY 28 2099-2106 (1989).
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Documentation | Enzymes that participate in the transfer of one-carbon units require
the coenzyme tetrahydrofolate (THF). Various reactions generate one-carbon
derivatives of THF, which can be interconverted between different oxidation
states by methylene-THF dehydrogenase, methenyl-THF cyclohydrolase and
formyl-THF synthetase [1,2]. The dehydrogenase and cyclohydrolase activities
are expressed by a variety of multifunctional enzymes, including the tri-
functional eukaryotic C1-tetrahydrofolate synthase [2]; a bifunctional
eukaryotic mitochondrial protein; and the bifunctional E.coli folD protein
[1,2].
Methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclo-
hydrolase share an overlapping active site [2], and as such are usually
located together in proteins, acting in tandem on the carbon-nitrogen bonds
of substrates other than peptide bonds.
THFDHDRGNASE is a 7-element fingerprint that provides a signature for the
tetrahydrofolate dehydrogenase/cyclohydrolase family. The fingerprint was
derived from an initial alignment of 5 motifs: the motifs were drawn from
conserved regions spanning virtually the full alignment length, motifs 2
and 7 including the N- and C-terminal regions encoded by PROSITE patterns
THF_DHG_CYH_1 (PS00766) and THF_DHG_CYH_2 (PS00767). Two iterations on
OWL25.1 were required to reach convergence, at which point a true set
comprising 11 sequences was identified. A single partial match was also
found, MTD1_YEAST, a methylenetetrahydrofolate dehydrogenase that shows
only slight similarity to the rest of the family.
An update on SPTR37_9f identified a true set of 26 sequences, and 5
partial matches.
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Summary Information | 26 codes involving 7 elements 3 codes involving 6 elements 1 codes involving 5 elements 1 codes involving 4 elements 0 codes involving 3 elements 0 codes involving 2 elements
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Composite Feature Index | 7 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 6 | 2 | 3 | 3 | 3 | 3 | 1 | 3 | 5 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 4 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
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True Positives | C1TC_HUMAN C1TC_RAT C1TC_YEAST C1TM_YEAST FOLD_BACSU FOLD_ECOLI FOLD_HAEIN FOLD_HELPY FOLD_PHOPO FOLD_SALTI FOLD_STRTR MTDC_DROME MTDC_HUMAN MTDC_MOUSE O42992 O43007 O51057 O65271 O67736 O68031 O83714 O84081 P77132 Q21285 Q27772 Q55626 |
True Positive Partials | |
Sequence Titles | C1TC_HUMAN C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC (C1-THF SYNTHASE) [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9); FORMYLTETRAHYDROFOLATE SYNTHETASE (EC 6.3.4.3)] - HOMO SAPIENS (HUMAN). C1TC_RAT C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC (C1-THF SYNTHASE) [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9); FORMYLTETRAHYDROFOLATE SYNTHETASE (EC 6.3.4.3)] - RATTUS NORVEGICUS (RAT). C1TC_YEAST C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC (C1-THF SYNTHASE) [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9); FORMYLTETRAHYDROFOLATE SYNTHETASE (EC 6.3.4.3)] - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). C1TM_YEAST C-1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL PRECURSOR (C1-THF SYNTHASE) [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9); FORMYLTETRAHYDROFOLATE SYNTHETASE (EC 6.3.4.3)] - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). FOLD_BACSU FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - BACILLUS SUBTILIS. FOLD_ECOLI FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - ESCHERICHIA COLI. FOLD_HAEIN FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - HAEMOPHILUS INFLUENZAE. FOLD_HELPY FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI). FOLD_PHOPO FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - PHOTOBACTERIUM PHOSPHOREUM. FOLD_SALTI FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - SALMONELLA TYPHI. FOLD_STRTR FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - STREPTOCOCCUS THERMOPHILUS. MTDC_DROME BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR [INCLUDES: NAD-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.15); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - DROSOPHILA MELANOGASTER (FRUIT FLY). MTDC_HUMAN BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR [INCLUDES: NAD-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.15); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - HOMO SAPIENS (HUMAN). MTDC_MOUSE BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR [INCLUDES: NAD-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.15); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - MUS MUSCULUS (MOUSE). O42992 C-1-TETRAHYDROFOLATE SYNTHASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). O43007 TETRAHYDROFOLATE SYNTHASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). O51057 METHYLENETETRAHYDROFOLATE DEHYDROGENASE (FOLD) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE). O65271 F6N23.26 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). O67736 METHYLENETETRAHYDROFOLATE DEHYDROGENASE - AQUIFEX AEOLICUS. O68031 METHYLENETETRAHYDROFOLATE DEHYDROGENASE / METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE HOMOLOG - RHODOBACTER CAPSULATUS (RHODOPSEUDOMONAS CAPSULATA). O83714 METHYLENETETRAHYDROFOLATE DEHYDROGENASE (FOLD) - TREPONEMA PALLIDUM. O84081 METHYLENE TETRAHYDROFOLATE DEHYDROGENASE - CHLAMYDIA TRACHOMATIS. P77132 METHYLENETETRAHYDROFOLATE DEHYDROGENASE/METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE - ESCHERICHIA COLI. Q21285 SIMILAR TO METHYLENETETRAHYDROFOLATE DEHYDROGENASE. NCBI GI: 1118056 - CAENORHABDITIS ELEGANS. Q27772 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC (C1-THF SYNTHASE) (METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5) / METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9) / FORMYLTETRAHYDROFOLATE SYNTHETASE (EC 6.3.4.3)) - SPODOPTERA FRUGIPERDA (FALL ARMYWORM). Q55626 METHYLENETETRAHYDROFOLATE DEHYDROGENASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803). O32879 METHYLENETETRAHYDROFOLATE DEHYDROGENASE - MYCOBACTERIUM LEPRAE. O50385 METHYLENETETRAHYDROFOLATE DEHYDROGENASE - MYCOBACTERIUM TUBERCULOSIS. O65269 F6N23.28 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). FOLD_MYCGE FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - MYCOPLASMA GENITALIUM. FOLD_MYCPN FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)] - MYCOPLASMA PNEUMONIAE.
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Scan History | OWL25_1 2 100 NSINGLE SPTR37_9f 2 38 NSINGLE
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Initial Motifs | Motif 1 width=23 Element Seqn Id St Int Rpt PGLAVVLVGSNPASQIYVASKRK FOLD_ECOLI 33 33 - PHLSVILVGDNPASHSYVLNKTR MTDC_MOUSE 68 68 - PHLSVILVGENPASHSYVLNKTR MTDC_HUMAN 62 62 - PTLKIIQVGARPDSSTYVRMKLK C1TM_YEAST 67 67 - PGLAILQVGDRDDSNLYINVKLK C1TC_RAT 35 35 - Motif 2 width=28 Element Seqn Id St Int Rpt SEAELLELIDTLNADNTIDGILVQLPLP FOLD_ECOLI 74 18 - SEEELLNSIRKLNNDENVDGLLVQLPLP MTDC_MOUSE 109 18 - SEEELLNLINKLNNDDNVDGLLVQLPLP MTDC_HUMAN 103 18 - TEVELLKKISDINDDDSIHGLLIQLPLP C1TM_YEAST 108 18 - TESEVLKYVISLNEDATVHGFIVQLPLD C1TC_RAT 76 18 - Motif 3 width=22 Element Seqn Id St Int Rpt VLERIHPDKDVDGFHPYNVGRL FOLD_ECOLI 109 7 - VCNAVSPDKDVDGFHVINVGRM MTDC_MOUSE 144 7 - ICNAVSPDKDVDGFHVINVGRM MTDC_HUMAN 138 7 - ITNAVDFKKDVDGFHRYNAGEL C1TM_YEAST 143 7 - VINAIAPEKDVDGLTSINAGKL C1TC_RAT 113 9 - Motif 4 width=21 Element Seqn Id St Int Rpt IDTFGLNAVVIGASNIVGRPM FOLD_ECOLI 154 23 - IPTLGKNVVVAGRSKNVGMPI MTDC_MOUSE 189 23 - IPTLGKNVVVAGRSKNVGMPI MTDC_HUMAN 183 23 - VKLDGKNAVVLGRSSIVGNPI C1TM_YEAST 190 25 - VQIAGRHAVVVGRSKIVGAPM C1TC_RAT 160 25 - Motif 5 width=30 Element Seqn Id St Int Rpt DLLIVAVGKPGFIPGDWIKEGAIVIDVGIN FOLD_ECOLI 203 28 - DIVISAAGIPNLITADMIKEGAAVIDVGIN MTDC_MOUSE 248 38 - DIVISAAGIPNLITADMIKEGAAVIDVGIN MTDC_HUMAN 242 38 - DIVIAACGIPQYVKSDWIKEGAVVIDVGIN C1TM_YEAST 239 28 - DILVVATGQPEMVKGEWIKPGAVVIDCGIN C1TC_RAT 209 28 - Motif 6 width=17 Element Seqn Id St Int Rpt KVVGDVVFEDAAKRASY FOLD_ECOLI 238 5 - KLVGDVDFEGVKKKAGY MTDC_MOUSE 288 10 - KLVGDVDFEGVRQKAGY MTDC_HUMAN 282 10 - KLVGDVDFDSVKEKTSY C1TM_YEAST 280 11 - KVVGDVAYDEAKEKASF C1TC_RAT 250 11 - Motif 7 width=19 Element Seqn Id St Int Rpt ITPVPGGVGPMTVATLIEN FOLD_ECOLI 255 0 - ITPVPGGVGPMTVAMLMKN MTDC_MOUSE 305 0 - ITPVPGGVGPMTVAMLMKN MTDC_HUMAN 299 0 - ITPVPGGVGPMTVAMLVSN C1TM_YEAST 297 0 - ITPVPGGVGPMTVAMLMQS C1TC_RAT 267 0 -
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Final Motifs | Motif 1 width=23 Element Seqn Id St Int Rpt PGLAVVLVGSNPASQIYVASKRK FOLD_ECOLI 33 33 - PGLAVVLVGSNPASQIYVASKRK FOLD_SALTI 33 33 - PGLAVILVGADPASQIYVGNKRK FOLD_HAEIN 33 33 - PGLAVVLVGSNPALQIYVASKRK P77132 34 34 - PGLAVVLVGQDPASQIYVGSKRK FOLD_PHOPO 34 34 - PHLSVILVGDNPASHSYVLNKTR MTDC_MOUSE 68 68 - PHLSVILVGENPASHSYVLNKTR MTDC_HUMAN 62 62 - PGLAVILIGDDPASHSYVRGKKK FOLD_BACSU 33 33 - PGLAVILVGDRKDSATYVRNKKK O65271 100 100 - PTLKIIQVGARPDSSTYVRMKLK C1TM_YEAST 67 67 - PALAVILVGNDPASEIYVNNKRK O67736 33 33 - PGLVVIMVGENPASQVYVRNKER FOLD_STRTR 33 33 - PGLAILQVGDRDDSNLYINVKLK C1TC_RAT 35 35 - PRLAILQVGNRDDSNLYINVKLK C1TC_HUMAN 35 35 - PHLTAVIVGEDPASEKYVANKMV MTDC_DROME 87 87 - VSLKIIQVGGREDSNVYVRMKTR O42992 34 34 - PALAIVQVGKREDSNVYVRMKEK O43007 48 48 - PGLAVVLIGNNPASEIYVNMKIK O84081 27 27 - PGLAVLMVGDNPASAVYVRNKEK Q55626 39 39 - PKLAVILVGKDPASITYVNMKIK FOLD_HELPY 39 39 - ARLAIVQVGGREDSNVYIRMKLR Q27772 34 34 - PFLAAVLVGDDPASCTYVAAKQR O83714 34 34 - AVLAIVQVGNRSDSNVYINSKLK Q21285 35 35 - PNLAIIQVGNRPDSATYVRMKRK C1TC_YEAST 35 35 - GRLVSISIGPSPEIEVYVRNQAR O68031 37 37 - IALKVVLANDEPASNLYVSIKSR O51057 38 38 - Motif 2 width=28 Element Seqn Id St Int Rpt SEAELLELIDTLNADNTIDGILVQLPLP FOLD_ECOLI 74 18 - SEAELLALIDTLNADNTIDGILVQLPLP FOLD_SALTI 74 18 - TQNELLAIIDQLNADKNIDGILVQLPLP FOLD_HAEIN 74 18 - SEAELLELIDTLNADNTIDGILVQLPLP P77132 75 18 - SEQQLLDLIDELNQDPTMDGILVQLPLP FOLD_PHOPO 75 18 - SEEELLNSIRKLNNDENVDGLLVQLPLP MTDC_MOUSE 109 18 - SEEELLNLINKLNNDDNVDGLLVQLPLP MTDC_HUMAN 103 18 - TEAELLSIIDQYNQDPEFHGILVQLPLP FOLD_BACSU 74 18 - SEEEVLKSVSGFNDDPSVHGILVQLPLP O65271 141 18 - TEVELLKKISDINDDDSIHGLLIQLPLP C1TM_YEAST 108 18 - SEEKLLGLIYELNMNEEVDGILVQLPLP O67736 74 18 - SEEELIEVIEKYNQNPLFHGILVQLPLP FOLD_STRTR 74 18 - TESEVLKYVISLNEDATVHGFIVQLPLD C1TC_RAT 76 18 - TESEVMKYITSLNEDSTVHGFLVQLPLD C1TC_HUMAN 76 18 - TQEELLQLIADLNKDPQVTGILVQLPVP MTDC_DROME 128 18 - TEYDLLLAIKGFNEDPTVHGIIVQLPLP O42992 75 18 - QMPALLHELKKLNDDHTVHGVLVQLPLP O43007 89 18 - TLSDILALIHQLNNDENIHGILVQLPLP O84081 68 18 - DQETLTAAIASLNEDERVDGILVQLPLP Q55626 80 18 - TEAKLLSLIKDYNTDQNISGVLVQLPLP FOLD_HELPY 80 18 - TETELLANITSLNESPYVHGIIVQMPLD Q27772 75 18 - SHAQVLELIARLNEDARVHGILIQLPLP O83714 75 18 - TQGDLKREIMALNHDNEIDGIIIQLPLD Q21285 76 18 - TEFEVLRYVDQLNEDPHTHGIIVQLPLP C1TC_YEAST 76 18 - TQEACKRKIAALNDDPSVLGIILQRPVP O68031 78 18 - VQSDILEVIDRENKNLSTDGIIVQLPLL O51057 79 18 - Motif 3 width=22 Element Seqn Id St Int Rpt VLERIHPDKDVDGFHPYNVGRL FOLD_ECOLI 109 7 - VLERIAPDKDVDGFHPYNVGRL FOLD_SALTI 109 7 - IIERIDPKKDVDGFHPYNVGRL FOLD_HAEIN 109 7 - VLERIHPDKDVDGFHPYNVGRL P77132 110 7 - ILERIDPEKDVDGFHPYNVGRL FOLD_PHOPO 110 7 - VCNAVSPDKDVDGFHVINVGRM MTDC_MOUSE 144 7 - ICNAVSPDKDVDGFHVINVGRM MTDC_HUMAN 138 7 - VIERISPDKDVDGFHPLNVGKM FOLD_BACSU 109 7 - ILNAVSIEKDVDGFHPLNIGRL O65271 176 7 - ITNAVDFKKDVDGFHRYNAGEL C1TM_YEAST 143 7 - VILSISPEKDVDGFHPENMGKL O67736 109 7 - ILLAIDPKKDVDGFHPMNTGNL FOLD_STRTR 109 7 - VINAIAPEKDVDGLTSINAGKL C1TC_RAT 113 9 - VINAIAPEKDVDGLTSINAGRL C1TC_HUMAN 113 9 - ICNAVDVDKDVDGFNEVNIGRT MTDC_DROME 163 7 - ITEAVAPEKDVDGFCETNLGKL O42992 110 7 - VTESITPPKDVDGFGAFNIGLL O43007 124 7 - ILSTITPDKDVDGLHPVNVGKL O84081 103 7 - LLHTIDPSKDADGLHPVNLGHL Q55626 115 7 - ILEAIDPNKDVDGFHPLNIGKL FOLD_HELPY 115 7 - ITDAVSPDKDVDGLNTINEGRV Q27772 112 9 - VCRAVAPEKDVDGFHPLNCGAL O83714 110 7 - VIDLIDPLKDVDGLTRINAGRL Q21285 113 9 - ITSRVLAEKDVDGFGPTNIGEL C1TC_YEAST 111 7 - LQSAIHPLKDVEGMNPASIGNI O68031 113 7 - ILNSIVYSKDVDGLSFVNLGKM O51057 114 7 - Motif 4 width=21 Element Seqn Id St Int Rpt IDTFGLNAVVIGASNIVGRPM FOLD_ECOLI 154 23 - IDTYGLNAVVIGASNIVGRPM FOLD_SALTI 154 23 - IDLHGKHAVIVGASNIVGRPM FOLD_HAEIN 154 23 - IDTFGLNAVVIGASNIVGRPM P77132 155 23 - IEVRGKHAVIVGASNIVGRPM FOLD_PHOPO 155 23 - IPTLGKNVVVAGRSKNVGMPI MTDC_MOUSE 189 23 - IPTLGKNVVVAGRSKNVGMPI MTDC_HUMAN 183 23 - IDLSGKEVVVVGRSNIVGKPV FOLD_BACSU 154 23 - IEIKGKRAVVIGRSNIVGMPA O65271 223 25 - VKLDGKNAVVLGRSSIVGNPI C1TM_YEAST 190 25 - IDVKGKDVTIVGAGFIVGRPL O67736 155 24 - VELEGKTAVIIGRSNIVGKPM FOLD_STRTR 154 23 - VQIAGRHAVVVGRSKIVGAPM C1TC_RAT 160 25 - VPIAGRHAVVVGRSKIVGAPM C1TC_HUMAN 160 25 - IETLGRNAVVVGRSKNVSLPM MTDC_DROME 208 23 - INVQGKHAVVIGRSNIVGRPM O42992 157 25 - ISVAGLNAVVLGRSDIVGNPI O43007 171 25 - IPLHGKHVVILGRSNIVGKPL O84081 149 24 - LDLTGKNAVVLGRSILVGKPL Q55626 160 23 - IEIKGKDVAIIGASNIIGKPL FOLD_HELPY 160 23 - VTIAGKNVVVLGRSRIVGTPV Q27772 158 24 - VPLAGARVVIVGRSAIVGRPL O83714 155 23 - NFVSGKEVVVLGRSKIVGSPA Q21285 163 28 - VTIEGSRSVVIGRSDIVGSPV C1TC_YEAST 158 25 - LPLPGLEVVMIGHSEIVGKPV O68031 158 23 - IKTLGKTVVVVGRSPLVGRPI O51057 160 24 - Motif 5 width=30 Element Seqn Id St Int Rpt DLLIVAVGKPGFIPGDWIKEGAIVIDVGIN FOLD_ECOLI 203 28 - DLLIVAVGKPGFIPGEWIKEGAIVIDVGIN FOLD_SALTI 203 28 - DILVVAVGKPNLISGDWIKESAVVIDVGIN FOLD_HAEIN 203 28 - DLLIVAVGKPGFIPGDWIKEGAIVIDVGIN P77132 204 28 - DILVVAVGKPNFIPGGWIKEGATVIDVGIN FOLD_PHOPO 204 28 - DIVISAAGIPNLITADMIKEGAAVIDVGIN MTDC_MOUSE 248 38 - DIVISAAGIPNLITADMIKEGAAVIDVGIN MTDC_HUMAN 242 38 - DILVVAVGRANFISADQIKEGAVVIDVGVN FOLD_BACSU 203 28 - DIIISAVGQPNMVRGSWIKPGAVLIDVGIN O65271 272 28 - DIVIAACGIPQYVKSDWIKEGAVVIDVGIN C1TM_YEAST 239 28 - DILISATGVPHLIKEDMIKEGAVVVDVGIS O67736 204 28 - DVLIVAIGRAKFVTEEFVKEGAVVIDVGIN FOLD_STRTR 203 28 - DILVVATGQPEMVKGEWIKPGAVVIDCGIN C1TC_RAT 209 28 - DILVVATGQPEMVKGEWIKPGAIVIDCGIN C1TC_HUMAN 209 28 - DIIVVAVGKPGLITKDMVKPGACVIDVGIN MTDC_DROME 267 38 - DIVVAAIGIPHFVKADWLKKGVVAIDVGIN O42992 206 28 - DLVIAALGKPEFVRGEWLKPGSVVVDVGIN O43007 220 28 - DILISAIGVPLFVNKEMIAEKTVIMDVGTS O84081 202 32 - DILVAAIGKPEFVTADMVKPGAIVVDVGIN Q55626 209 28 - DIVCVGVGKPDLIKASMLKKGAVVVDIGIN FOLD_HELPY 209 28 - DILVVAIGRGEMVRGSWIKPGAVVIDCGIN Q27772 207 28 - DILVAALGKARFIGAPFVRTGAVVIDVGIH O83714 206 30 - DILIVAIGRKHFVKADWIKPGAFVIDCGIN Q21285 212 28 - DIVVVAIGQPEFVKGEWFKPRDGTSSDKKT C1TC_YEAST 207 28 - DVVIVAVGKAHLIGPEMIKPGAAVIDIGIN O68031 207 28 - DIVISAVGKPRLIDKSMLCGKPYVIDIGIS O51057 211 30 - Motif 6 width=17 Element Seqn Id St Int Rpt KVVGDVVFEDAAKRASY FOLD_ECOLI 238 5 - KVVGDVVFDEAAARASY FOLD_SALTI 238 5 - KLVGDVEFDKAAEKAAY FOLD_HAEIN 237 4 - KVVGDVVFEDAAKRASY P77132 239 5 - KLCGDVEFDVACQRAKY FOLD_PHOPO 239 5 - KLVGDVDFEGVKKKAGY MTDC_MOUSE 288 10 - KLVGDVDFEGVRQKAGY MTDC_HUMAN 282 10 - KLCGDVEFEGAKEKASF FOLD_BACSU 238 5 - RLVGDICYEEASKVASA O65271 313 11 - KLVGDVDFDSVKEKTSY C1TM_YEAST 280 11 - KIVGDVDFERVKEKASA O67736 238 4 - KLCGDVDFDQVKEKVSM FOLD_STRTR 238 5 - KVVGDVAYDEAKEKASF C1TC_RAT 250 11 - KVVGDVAYDEAKERASF C1TC_HUMAN 250 11 - KLVGDVDFEEVRQVAGH MTDC_DROME 307 10 - RLTGDIDFENAKEVASA O42992 247 11 - VLVGDVHFESASKVASS O43007 258 8 - ILVGDVDFNNVVPVCRA O84081 242 10 - TLVGDVDFAGVAPVASY Q55626 248 9 - RIVGDVDFNNVQKVAGF FOLD_HELPY 244 5 - RLVGDVAYEEAVQVASH Q27772 248 11 - RLCGDVDFDAVAHKVQA O83714 247 11 - KIYGDVDTEAAKEVAGF Q21285 250 8 - KCVGDVEFNEAIKYVHL C1TC_YEAST 256 19 - RILGDVDTEAVREVAGW O68031 246 9 - ILSGDTDFDNIKECVKF O51057 249 8 - Motif 7 width=19 Element Seqn Id St Int Rpt ITPVPGGVGPMTVATLIEN FOLD_ECOLI 255 0 - ITPVPGGVGPMTVATLIEN FOLD_SALTI 255 0 - ITPVPGGVGPMTVAMLMSN FOLD_HAEIN 254 0 - ITPVPGGVGPMTVATLIEN P77132 256 0 - ITPVPGGVGPMTVASLIEN FOLD_PHOPO 256 0 - ITPVPGGVGPMTVAMLMKN MTDC_MOUSE 305 0 - ITPVPGGVGPMTVAMLMKN MTDC_HUMAN 299 0 - ITPVPGGVGPMTITMLAHN FOLD_BACSU 255 0 - ITPVPGGVGPMTIAMLLSN O65271 330 0 - ITPVPGGVGPMTVAMLVSN C1TM_YEAST 297 0 - ITPVPGGVGPMTVTALLLN O67736 255 0 - ITPVPGGVGPMTITMLMEQ FOLD_STRTR 255 0 - ITPVPGGVGPMTVAMLMQS C1TC_RAT 267 0 - ITPVPGGVGPMTVAMLMQS C1TC_HUMAN 267 0 - ITPVPGGVGPMTVAMLMHN MTDC_DROME 324 0 - ITPVPGSVGPMTVAMLLQN O42992 264 0 - ITPVPGGVGPMTVAMLMEN O43007 275 0 - ITPVPGGVGPMTVAMLMRN O84081 259 0 - LTPVPGGIGPMTVTLLLAN Q55626 265 0 - ITPVPKGVGPMTIVSLLEN FOLD_HELPY 261 0 - VTPVPGGVGPMTVAMLMRN Q27772 265 0 - ITPVPGGVGPMTIAMLLHN O83714 264 0 - LTPVPGGVGPMTVAMLIRN Q21285 267 0 - ITPVPGGVGPMTVAMLMQN C1TC_YEAST 273 0 - ITPVPGGVGPVTVAMLMRN O68031 263 0 - ITPVKGGIGPVTVLMLMFN O51057 266 0 -
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