Identifier | HOLDHDRGNASE  [View Relations]  [View Alignment]  
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Accession | PR00083 |
No. of Motifs | 9 |
Creation Date | 06-FEB-1995  (UPDATE 10-JUN-1999) |
Title | Histidinol dehydrogenase signature |
Database References | PROSITE; PS00611 HISOL_DEHYDROGENASE BLOCKS; BL00611 PFAM; PF00815 Histidinol_dh INTERPRO; IPR001692 UMBBD; e0432
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Literature References | 1. GRUBMEYER, C.T. AND GRAY, W.R.
A cysteine residue (cysteine-116) in the histidinol binding site of
histidinol dehydrogenase.
BIOCHEMISTRY 25 4778-4784 (1986).
2. LEGERTON, T.L. AND YANOFSKY, C.
Cloning and characterization of the multifunctional his-3 gene of
Neurospora crassa.
GENE 39 129-140 (1985).
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Documentation | Histidinol dehydrogenase catalyses the final step in microbial histidine
biosynthesis, the 4-electron oxidation of L-histidinol to histidine [1]. In
4-electron dehydrogenases, a single active site catalyses 2 separate
oxidation steps: oxidation of the substrate alcohol to an intermediate
aldehyde; and oxidation of the aldehyde to the product acid, in this case
His [1]. The reaction proceeds via a tightly- or covalently-bound inter-
mediate, and requires the presence of 2 NAD molecules [1]. By contrast with
most dehydrogenases, the substrate is bound before the NAD coenzyme [1]. A
Cys residue has been implicated in the catalytic mechanism of the second
oxidative step [1]. Bacterial histidinol dehydrogenase is a distinct single-
chain enzyme [1], but is part of a multifunctional enzyme in fungi [2].
HOLDHDRGNASE is a 9-element fingerprint that provides a signature for
histidinol dehydrogenases. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, motif 2 including the region
encoded by PROSITE pattern HISOL_DEHYDROGENASE (PS00611), which contains
the catalytically important Cys. Two iterations on OWL25.1 were required
to reach convergence, at which point a true set comprising 12 sequences
was identified. Two partial matches were also found (S24815 and PPPPIC3K),
both of which are C-terminally truncated histidinol dehydrogenase fragments.
An update on SPTR37_9f identified a true set of 22 sequences, and 2
partial matches.
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Summary Information | 22 codes involving 9 elements 0 codes involving 8 elements 0 codes involving 7 elements 1 codes involving 6 elements 0 codes involving 5 elements 0 codes involving 4 elements 1 codes involving 3 elements 0 codes involving 2 elements
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Composite Feature Index | 9 | 22 | 22 | 22 | 22 | 22 | 22 | 22 | 22 | 22 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
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True Positives | HIS2_KLULA HIS2_NEUCR HIS2_PICPA HIS2_SACBA HIS2_YEAST HISX_ARCFU HISX_BACSU HISX_BRAOC HISX_ECOLI HISX_HAEIN HISX_LACLA HISX_METJA HISX_METTH HISX_MYCSM HISX_MYCTU HISX_SALTY HISX_STRCO HISX_SULSO HISX_SYNY3 O59626 O66976 O74712 |
True Positive Partials | Codes involving 6 elements Q12201 | Codes involving 3 elements P72946 |
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Sequence Titles | HIS2_KLULA HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - KLUYVEROMYCES LACTIS (YEAST). HIS2_NEUCR HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - NEUROSPORA CRASSA. HIS2_PICPA HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - PICHIA PASTORIS (YEAST). HIS2_SACBA HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - SACCHAROMYCES BAYANUS (YEAST). HIS2_YEAST HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). HISX_ARCFU HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - ARCHAEOGLOBUS FULGIDUS. HISX_BACSU HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - BACILLUS SUBTILIS. HISX_BRAOC HISTIDINOL DEHYDROGENASE, CHLOROPLAST PRECURSOR (EC 1.1.1.23) (HDH) - BRASSICA OLERACEA VAR. CAPITATA (CABBAGE). HISX_ECOLI HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - ESCHERICHIA COLI. HISX_HAEIN HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - HAEMOPHILUS INFLUENZAE. HISX_LACLA HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - LACTOCOCCUS LACTIS (SUBSP. LACTIS) (STREPTOCOCCUS LACTIS). HISX_METJA HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - METHANOCOCCUS JANNASCHII. HISX_METTH HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - METHANOBACTERIUM THERMOAUTOTROPHICUM. HISX_MYCSM HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - MYCOBACTERIUM SMEGMATIS. HISX_MYCTU HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - MYCOBACTERIUM TUBERCULOSIS. HISX_SALTY HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - SALMONELLA TYPHIMURIUM. HISX_STRCO HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - STREPTOMYCES COELICOLOR. HISX_SULSO HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - SULFOLOBUS SOLFATARICUS. HISX_SYNY3 HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - SYNECHOCYSTIS SP. (STRAIN PCC 6803). O59626 HISTIDINOL DEHYDROGENASE - PYROCOCCUS FURIOSUS. O66976 HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH) - AQUIFEX AEOLICUS. O74712 HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN [INCLUDES: PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19); PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31); HISTIDINOL DEHYDROGENASE (EC 1.1.1.23) (HDH)] - CANDIDA ALBICANS (YEAST). Q12201 DNA FOR PPIC9K EXPRESSION VECTOR - PICHIA PASTORIS (YEAST). P72946 HISTIDINOL DEHYDROGENASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
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Scan History | OWL25_1 2 100 NSINGLE SPTR37_9f 2 24 NSINGLE
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Initial Motifs | Motif 1 width=25 Element Seqn Id St Int Rpt VNPIIENVRDKGNSALLEYTEKFDG HIS2_YEAST 388 388 - VNDILDNVKARGDEALREYSAKFDK HISX_ECOLI 36 36 - VSDILDNVKTRGDDALREYSAKFDK HISX_SALTY 36 36 - IVPIIEDVRKNGDKAVLSYTHKFEK HIS2_NEUCR 462 462 - VNPIIDAVRSKGDTAVKEYTERFDK HISX_BRAOC 64 64 - Motif 2 width=28 Element Seqn Id St Int Rpt VETQPGVLCSRFPRPIEKVGLYIPGGTA HIS2_YEAST 462 49 - VETQPGVRCQQVTRPVASVGLYIPGGSA HISX_ECOLI 109 48 - VETQPGVRCQQVTRPVSSVGLYIPGGSA HISX_SALTY 109 48 - VETMPGVVCSRFSRPIEAVGCYIPGGTA HIS2_NEUCR 536 49 - VENMKGVRCKRVSRSIGSVGLYVPGGTA HISX_BRAOC 135 46 - Motif 3 width=27 Element Seqn Id St Int Rpt ILPSTALMLGVPAQVAQCKEIVFASPP HIS2_YEAST 490 0 - PLFSTVLMLATPARIAGCKKVVLCSPP HISX_ECOLI 137 0 - PLFSTVLMLATPARIAGCQKVVLCSPP HISX_SALTY 137 0 - VLPSTALMLGVPAMVAGCNKIVFASPP HIS2_NEUCR 564 0 - VLPSTALMLAIPAQIAGCKTVVLATPP HISX_BRAOC 163 0 - Motif 4 width=27 Element Seqn Id St Int Rpt EVVYVAEKVGASKIVLAGGAQAVAAMA HIS2_YEAST 526 9 - EILYAAQLCGVQDVFNVGGAQAIAALA HISX_ECOLI 168 4 - EILYAAQLCGVQEIFNVGGAQAIAALA HISX_SALTY 168 4 - EIVYVAHKVGAESIVLAGGAQAVAAMV HIS2_NEUCR 599 8 - EVLYCAKRAGVTHILKAGGAQAIAAMA HISX_BRAOC 198 8 - Motif 5 width=26 Element Seqn Id St Int Rpt ETIPKVDKILGPGNQFVTAAKMYVQN HIS2_YEAST 556 3 - ESVPKVDKIFGPGNAFVTEAKRQVSQ HISX_ECOLI 198 3 - ESVPKVDKIFGPGNAFVTEAKRQVSQ HISX_SALTY 198 3 - ESITKVDKILGPGNQFVTAANMFVSN HIS2_NEUCR 628 2 - DSCPKVEKIFGPGNQYVTAAKMILQN HISX_BRAOC 228 3 - Motif 6 width=22 Element Seqn Id St Int Rpt IDMPAGPSEVLVIADEDADVDF HIS2_YEAST 589 7 - IDMPAGPSEVLVIADSGATPDF HISX_ECOLI 230 6 - IDMPAGPSEVLVIADSGATPDF HISX_SALTY 230 6 - IDMPAGPSEVLVIAHKDANPAF HIS2_NEUCR 661 7 - IDMPAGPSEVLVIADEHASPVY HISX_BRAOC 260 6 - Motif 7 width=20 Element Seqn Id St Int Rpt VASDLLSQAEHGIDSQVILV HIS2_YEAST 611 0 - VASDLLSQAEHGPDSQVILL HISX_ECOLI 252 0 - VASDLLSQAEHGPDSQVILL HISX_SALTY 252 0 - VASDLLSRAEHGVDSQVILI HIS2_NEUCR 683 0 - IAADLLSQAEHGPDSQVVLV HISX_BRAOC 282 0 - Motif 8 width=26 Element Seqn Id St Int Rpt SNQYAPEHLILQIANANDYVKLVDNA HIS2_YEAST 681 50 - SNQYGPEHLIIQTRNARELVDSITSA HISX_ECOLI 320 48 - SNQYGPEHLIIQTRNARDLVDAITSA HISX_SALTY 320 48 - SNKYAPEHLILQIKEAEKAVDLVMNA HIS2_NEUCR 753 50 - SNLYAPEHLIINVKDAEKWEGLIENA HISX_BRAOC 351 49 - Motif 9 width=19 Element Seqn Id St Int Rpt YSSGTNHTLPTYGYARQYS HIS2_YEAST 722 15 - YASGTNHVLPTYGYTATCS HISX_ECOLI 361 15 - YASGTNHVLPTYGYTATCS HISX_SALTY 361 15 - YSAGVNHSLPTYGFAKQYS HIS2_NEUCR 791 12 - YASGTNHVLPTYGYARMYS HISX_BRAOC 392 15 -
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Final Motifs | Motif 1 width=25 Element Seqn Id St Int Rpt VNPIIENVRDRGDSALLEYTEKFDG HIS2_SACBA 388 388 - VNPIIENVRDKGNSALLEYTEKFDG HIS2_YEAST 388 388 - VNPIIENVIKNGDKALVELTAKFDG HIS2_KLULA 384 384 - VKPIVDNVRQNGDKALLELTAKFDG HIS2_PICPA 440 440 - VNDILDNVKARGDEALREYSAKFDK HISX_ECOLI 36 36 - VSDILDNVKTRGDDALREYSAKFDK HISX_SALTY 36 36 - VNAIRENVAYNGDRALFELCEKFDG HISX_HAEIN 33 33 - VLPIIEKVKSDGDKALIELTSKFDG O74712 430 430 - IVPIIEDVRKNGDKAVLSYTHKFEK HIS2_NEUCR 462 462 - VNPIIDAVRSKGDTAVKEYTERFDK HISX_BRAOC 64 64 - VADIISMVRDGGDDALRELTGRFDG HISX_METTH 31 31 - VMEILKDVKEKGDEALKYYTKKFDG HISX_METJA 36 36 - VQQIVADIQKNGDTALFNYAKKFDG HISX_LACLA 33 33 - VKEILKRVREEGDRAVIEFTKKFDG O66976 35 35 - VRSIIEDVKANGDQAVRSYTAKFDC HISX_BACSU 29 29 - VRPIVDAVAQRGAQAALEYGESFDG HISX_MYCSM 42 42 - VRPIVAAVAERGAEAALDFGASFDG HISX_MYCTU 35 35 - VKPIVEAVKREGDKAVIRFTRDLDG HISX_ARCFU 20 20 - VRPICEAVHHRGDAALIDFTEQFDG HISX_STRCO 36 36 - VREILKDIRERGLEAIREYSKKFDG O59626 7 7 - VKDIIESVKTKGDNALYELTEKLDK HISX_SULSO 21 21 - AKEVIEQVKMEGDAGVLHYSRQFDF HISX_SYNY3 33 33 - Motif 2 width=28 Element Seqn Id St Int Rpt VETQPGVLCSRFPRPIEKVGLYIPGGTA HIS2_SACBA 462 49 - VETQPGVLCSRFPRPIEKVGLYIPGGTA HIS2_YEAST 462 49 - VETQPGVVCSRFPRPIEKVGLYIPGGTA HIS2_KLULA 458 49 - VETCPGVVCSRFARPIEKVGLYIPGGTA HIS2_PICPA 512 47 - VETQPGVRCQQVTRPVASVGLYIPGGSA HISX_ECOLI 109 48 - VETQPGVRCQQVTRPVSSVGLYIPGGSA HISX_SALTY 109 48 - LEIQEGVRCQVVTRPISCVGLYIPGGSA HISX_HAEIN 106 48 - VETSPGVYCSRFAKPIENVGLYVPGGTA O74712 504 49 - VETMPGVVCSRFSRPIEAVGCYIPGGTA HIS2_NEUCR 536 49 - VENMKGVRCKRVSRSIGSVGLYVPGGTA HISX_BRAOC 135 46 - SEVRPGVMAGQLVRPIDSVGCYIPGGRA HISX_METTH 104 48 - NVENNGIILGQVVRAIEKVGCYVPGGRA HISX_METJA 110 49 - IFKENGVIMGQIARPLERVALYVPGGTA HISX_LACLA 108 50 - FKEEEGIILGQKVVPLEKVGVYVPGGKA O66976 109 49 - YHRKDGTMLGQKVTALDSAGVYVPGGTA HISX_BACSU 102 48 - TTLAPGATVTERWVPVERVGLYVPGGNA HISX_MYCSM 115 48 - TTLGPGATVTERWVPVERVGLYVPGGNA HISX_MYCTU 108 48 - KVEFEDCVMGKIYTPIEKVGAYIPGGRA HISX_ARCFU 93 48 - TQVVPGGSVTEKWVPVERVGLYVPGGRS HISX_STRCO 109 48 - LYIENGSLYGLIYKPLKRIRIYVPGGKP O59626 78 46 - GGGYQGISFGVIWRSIEKIGIYVPSGKY HISX_SULSO 93 47 - AEIEPGVFAGEKITPLPTVGLYVPRGKG HISX_SYNY3 109 51 - Motif 3 width=27 Element Seqn Id St Int Rpt ILPSTALMLGVPAQVAQCKEIVFASPP HIS2_SACBA 490 0 - ILPSTALMLGVPAQVAQCKEIVFASPP HIS2_YEAST 490 0 - ILPSTALMLGVPAQVAGCKEIVFASPP HIS2_KLULA 486 0 - ILPSTSLMLGVPAKVAGCKEIVFASPP HIS2_PICPA 540 0 - PLFSTVLMLATPARIAGCKKVVLCSPP HISX_ECOLI 137 0 - PLFSTVLMLATPARIAGCQKVVLCSPP HISX_SALTY 137 0 - PLFSTVLMLAIPAKIAGCKKIVLCSPP HISX_HAEIN 134 0 - VLPSTAMMLGVPAKVAGCKNIIVASPP O74712 532 0 - VLPSTALMLGVPAMVAGCNKIVFASPP HIS2_NEUCR 564 0 - VLPSTALMLAIPAQIAGCKTVVLATPP HISX_BRAOC 163 0 - VYPSTILMTVIPARIAGVERIVCCTPP HISX_METTH 132 0 - FYPSTVLMTTIPAKVAGCEEIYITSPP HISX_METJA 138 0 - AYPSTVIMNAVPALLAGVKEIIMITPV HISX_LACLA 136 0 - AYPSTVLMNVVPASVAGVEEIIMVSPK O66976 137 0 - AYPSSVLMNVIPALVAGVERIVLVTPP HISX_BACSU 130 0 - VYPSSVVMNVVPAQTAGVDSMVIASPP HISX_MYCSM 143 0 - VYPSSVVMNVVPAQAAGVDSLVVASPP HISX_MYCTU 136 0 - SYPSTALMIGVPAKIAGVEKLVACTPP HISX_ARCFU 121 0 - VYPSSVVMNVVPAQEAGVGSIALASPA HISX_STRCO 137 0 - PLPSTLMMVGVPARVAGVKEIVVTNPP O59626 105 -1 - SYPSTLLMAGIPAKVAKVKEIYVASPP HISX_SULSO 121 0 - AFPSMMLMLAVPARVAGVKKIVVCTPP HISX_SYNY3 137 0 - Motif 4 width=27 Element Seqn Id St Int Rpt EVVYVAEKVGARMIVLAGGAQAVAAMA HIS2_SACBA 526 9 - EVVYVAEKVGASKIVLAGGAQAVAAMA HIS2_YEAST 526 9 - EVVYVASKVGASKIVLAGGAQAIAAMA HIS2_KLULA 522 9 - EVIYVAHKVGAKCIVLAGGAQAVAAMA HIS2_PICPA 575 8 - EILYAAQLCGVQDVFNVGGAQAIAALA HISX_ECOLI 168 4 - EILYAAQLCGVQEIFNVGGAQAIAALA HISX_SALTY 168 4 - EILYTAHLCGVETIYAIGGAQAVFAMA HISX_HAEIN 165 4 - EVVYVAHKLGAKCIVMAGGAQAVTAMA O74712 568 9 - EIVYVAHKVGAESIVLAGGAQAVAAMV HIS2_NEUCR 599 8 - EVLYCAKRAGVTHILKAGGAQAIAAMA HISX_BRAOC 198 8 - AVLVAADMAGASEIYRVGGAQAVAAMA HISX_METTH 167 8 - ATLIAGDIVGVSAIYKVGGVQAIGALA HISX_METJA 173 8 - NILAAAEVCGIETIYKVGGAQGVAAVA HISX_LACLA 171 8 - YTLAAAYIAGVSRVFQVGGAQAIGALA O66976 167 3 - GVLVAAAELGIKDIYKMGGAQAIAALA HISX_BACSU 165 8 - TILAAAALLGVDEVWAVGGAQAVALLA HISX_MYCSM 180 10 - TILAAARLLGVDEVWAVGGAQAVALLA HISX_MYCTU 173 10 - LTLVALDIAEFDEVYKAGGAQAIAAMA HISX_ARCFU 156 8 - TILAACALLGVDEVYAAGGATAVAMFA HISX_STRCO 174 10 - YILYIAKLLKIEEVYKLGGIQAIAAMA O59626 139 7 - ALAYVAIKLGVNEVYKIGGAQAIAALA HISX_SULSO 156 8 - VSLVTARMAGVDEVYKLGGVQALAAIA HISX_SYNY3 172 8 - Motif 5 width=26 Element Seqn Id St Int Rpt ETIPKVDKVLGPGNQFVTAAKMYVQN HIS2_SACBA 556 3 - ETIPKVDKILGPGNQFVTAAKMYVQN HIS2_YEAST 556 3 - ESVPKVDKILGPGNQFVTAAKMYVQN HIS2_KLULA 552 3 - ETVPKCDKIFGPGNQFVTAAKMMVQN HIS2_PICPA 605 3 - ESVPKVDKIFGPGNAFVTEAKRQVSQ HISX_ECOLI 198 3 - ESVPKVDKIFGPGNAFVTEAKRQVSQ HISX_SALTY 198 3 - ESVAKVDKIFGPGNAFVTEAKRQVAQ HISX_HAEIN 195 3 - ESVLKCDKILGPGNQFVTAAKMYVQN O74712 598 3 - ESITKVDKILGPGNQFVTAANMFVSN HIS2_NEUCR 628 2 - DSCPKVEKIFGPGNQYVTAAKMILQN HISX_BRAOC 228 3 - ETIRPVDKIVGPGNIFVTAAKKLVYG HISX_METTH 197 3 - ETIPKVDIIVGPGNIYVTTAKKMVYG HISX_METJA 203 3 - ESIPKVDKIVGPGNIFVATAKKICYG HISX_LACLA 201 3 - EKIPKVDKIVGPGNIYVALAKKLVFG O66976 197 3 - ETIEPVDKITGPGNIYVALAKREVFG HISX_BACSU 195 3 - AELAPVDMITGPGNIYVTAAKRICRS HISX_MYCSM 215 8 - AALTPVDMITGPGNIYVTAAKRLCRS HISX_MYCTU 208 8 - ETVEKVYKIVGPGNIYVTAAKLLVAK HISX_ARCFU 186 3 - ESCPPANMVTGPGNIWVAAAKRFFTG HISX_STRCO 204 3 - IGMKKVQKIFGPGNKFVNEAKRQVFG O59626 168 2 - ESVKKVYKIVGPGNVYVQAAKYLVSS HISX_SULSO 186 3 - KTVSKVDKLIGPCSIYGAAAKRLLSG HISX_SYNY3 202 3 - Motif 6 width=22 Element Seqn Id St Int Rpt IDMPAGPSEVLVIADEDADADF HIS2_SACBA 589 7 - IDMPAGPSEVLVIADEDADVDF HIS2_YEAST 589 7 - IDMPAGPSEVLVICDEEADVDF HIS2_KLULA 585 7 - IDMPAGPSEVLVIADKYADPDF HIS2_PICPA 638 7 - IDMPAGPSEVLVIADSGATPDF HISX_ECOLI 230 6 - IDMPAGPSEVLVIADSGATPDF HISX_SALTY 230 6 - IDMPAGPSEVLVIADESADPEF HISX_HAEIN 225 4 - IDMPAGPSEVLVIADSNADADF O74712 631 7 - IDMPAGPSEVLVIAHKDANPAF HIS2_NEUCR 661 7 - IDMPAGPSEVLVIADEHASPVY HISX_BRAOC 260 6 - IDFPAGPSEVLIIADETASPEY HISX_METTH 226 3 - IDFLAGPSEVLIIADETANAEF HISX_METJA 232 3 - IDMIAGPSEVLVIADKTAKPKY HISX_LACLA 230 3 - IDMIAGPSEVLVIADERANPTW O66976 226 3 - IDMIAGPSEIVVLADETAIPSE HISX_BACSU 224 3 - IDAEAGPTEIAILADHTADPVH HISX_MYCSM 244 3 - IDAEAGPTEIAILADHTADPVH HISX_MYCTU 237 3 - IDMPAGPSEILVIADETANADF HISX_ARCFU 215 3 - IDAEAGPTEIAVLADSTADPVH HISX_STRCO 233 3 - IDSLAGPSEIAVIADESADKDF O59626 197 3 - IDGIEGPTELVIIADETAKAEY HISX_SULSO 215 3 - VGLPAGPSESIVLADETTDPKL HISX_SYNY3 231 3 - Motif 7 width=20 Element Seqn Id St Int Rpt VASDLLSQAEHGIDSQVILV HIS2_SACBA 611 0 - VASDLLSQAEHGIDSQVILV HIS2_YEAST 611 0 - VASDLLSQAEHGIDSQVILV HIS2_KLULA 607 0 - VVSDLLSQAEHGIDSQVILL HIS2_PICPA 660 0 - VASDLLSQAEHGPDSQVILL HISX_ECOLI 252 0 - VASDLLSQAEHGPDSQVILL HISX_SALTY 252 0 - VASDLLSQAEHGADSQVILV HISX_HAEIN 247 0 - VASDLLSQAEHGVDSQVILI O74712 653 0 - VASDLLSRAEHGVDSQVILI HIS2_NEUCR 683 0 - IAADLLSQAEHGPDSQVVLV HISX_BRAOC 282 0 - IALEILAQAEHDPQAASVLV HISX_METTH 248 0 - VALDFIAQAEHDPNASCVIT HISX_METJA 254 0 - IAADLMAQAEHDKLASAILV HISX_LACLA 252 0 - VAADMLSQAEHDELAASILL O66976 248 0 - IAADLLSQAEHDKLSSCVFV HISX_BACSU 246 0 - VAADLISQAEHDEMAASVLV HISX_MYCSM 266 0 - VAADLISQAEHDELAASVLV HISX_MYCTU 259 0 - IACDCLAQLEHDPMAVAVVL HISX_ARCFU 237 0 - VASDLISLAEHDPLAAAVLV HISX_STRCO 255 0 - VLYDLLSQLEHGKDSKAWLL O59626 219 0 - VALDMKAQAEHGPDTYIVLL HISX_SULSO 237 0 - AALDLLIEAEHGSDSAALLV HISX_SYNY3 253 0 - Motif 8 width=26 Element Seqn Id St Int Rpt SNKYAPEHLILQIANANDYVKLVDNA HIS2_SACBA 681 50 - SNQYAPEHLILQIANANDYVKLVDNA HIS2_YEAST 681 50 - SNQYAPEHLILQISNAEDYVKDVDHA HIS2_KLULA 677 50 - SNQYAPEHLILQIENASYVDQVQHAG HIS2_PICPA 730 50 - SNQYGPEHLIIQTRNARELVDSITSA HISX_ECOLI 320 48 - SNQYGPEHLIIQTRNARDLVDAITSA HISX_SALTY 320 48 - SNEYAPEHLIVQTKNARKLLPYLDNA HISX_HAEIN 315 48 - SNQYAPEHLILQIDDAPSYVPDSIEN O74712 723 50 - SNKYAPEHLILQIKEAEKAVDLVMNA HIS2_NEUCR 753 50 - SNLYAPEHLIINVKDAEKWEGLIENA HISX_BRAOC 351 49 - SNAYAPEHLVIMTDSPEETLEGIRNA HISX_METTH 317 49 - SNKYAPEHLEILTKNPEEVLNKIKHA HISX_METJA 321 47 - SNQLAPEHLEVLTSEPLTQLPKIKNA HISX_LACLA 321 49 - ANYIAPEHLEVMVREPMALLPELKHA O66976 317 49 - VNTLAPEHLEIITQSPEALLGSIKHA HISX_BACSU 315 49 - VNAYAAEHLEIQTVDAPGVAGRIRSA HISX_MYCSM 336 50 - VNAYAAEHLEIQTADAPQVASRIRSA HISX_MYCTU 329 50 - SNEFAPEHLTVAVKNPEEWLGKVRNA HISX_ARCFU 294 37 - VDAYGAEHLEIQTADAAAVADRVKNA HISX_STRCO 326 51 - ANEIAPEHLEIITREPLKLVDLIENA O59626 268 29 - ANKIAPEHLSLYVKDAYTLMDKIVNA HISX_SULSO 292 35 - INDYAPEHLQVLTADPLKLVGKIDNA HISX_SYNY3 324 51 - Motif 9 width=19 Element Seqn Id St Int Rpt YSSGTNHTLPTYGYARQYS HIS2_SACBA 722 15 - YSSGTNHTLPTYGYARQYS HIS2_YEAST 722 15 - YSSGTNHTLPTYGYARQYS HIS2_KLULA 718 15 - YSSGTNHTLPTYGYARQYS HIS2_PICPA 770 14 - YASGTNHVLPTYGYTATCS HISX_ECOLI 361 15 - YASGTNHVLPTYGYTATCS HISX_SALTY 361 15 - YASGTNHVLPTYGYTKTYS HISX_HAEIN 356 15 - YSSGTNHTLPTYGYARQYS O74712 765 16 - YSAGVNHSLPTYGFAKQYS HIS2_NEUCR 791 12 - YASGTNHVLPTYGYARMYS HISX_BRAOC 392 15 - YGSGTNHVLPTSGCARMYS HISX_METTH 358 15 - YASGTNHVLPTSQFARMSS HISX_METJA 362 15 - YMSGSNHVLPTGGTAKFYS HISX_LACLA 362 15 - YVLGPNHTLPTGGSTRFFS O66976 358 15 - YFAGPNHVLPTNGTARFSS HISX_BACSU 356 15 - YCAGSNHVLPTAGCARHSS HISX_MYCSM 377 15 - YCAGSNHVLPTAGCARHSS HISX_MYCTU 370 15 - YASGTNHVLPTAGYAKIYG HISX_ARCFU 335 15 - YAAGSNHVLPTGGCACHSS HISX_STRCO 367 15 - YFLGVNHVLPTGGAAKFMG O59626 309 15 - YVAGPNHILPTNGWAKIRG HISX_SULSO 332 14 - YAIGVNAVLPTGGFARSYS HISX_SYNY3 365 15 -
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