| Literature References | 1. FOUTS, D., GANGULY, R., GUTIERREZ, A.G., LUCCHESI, J.C. AND MANNING, J.E.
Nucleotide sequence of the Drosophila glucose-6-phosphate dehydrogenase
gene and comparison with the homologous human gene.
GENE 63 261-275 (1988).
2. VULLIAMY, T.J., D'URSO, M., BATTISTUZZI, G., ESTRADA, M., FOULKES, N.S.,
MARTINI, G., CALABRO, V., POGGI, V., GIORDANO, R., TOWN, M., LUZZATTO, L.
AND PERSICO, M.G.
Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene
cause enzyme deficiency and mild or severe hemolytic anemia.
PROC.NATL.ACAD.SCI.U.S.A. 85 5171-5175 (1988).
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| Documentation | Glucose-6-phosphate dehydrogenase (G6PDH) is a ubiquitous protein, present
in bacteria and all eukaryotic cell types [1]. The enzyme catalyses the
the first step in the pentose pathway, i.e. the conversion of glucose-6-
phosphate to gluconolactone 6-phosphate in the presence of NADP, producing
NADPH [1]. The ubiquitous expression of the enzyme gives it a major role
in the production of NADPH for the many NADPH-mediated reductive processes
in all cells [1,2]. Deficiency of G6PDH is a common genetic abnormality
affecting millions of people worldwide [2]: many sequence variants, most
caused by single point mutations, are known, exhibiting a wide variety of
phenotypes [2].
G6PDHDRGNASE is a 5-element fingerprint that provides a signature for
glucose-6-phosphate dehydrogenases. The fingerprint was derived from an
initial alignment of 5 sequences: the motifs were drawn from conserved
regions within the central portion of the alignment, motif 2 including the
region encoded by PROSITE pattern G6P_DEHYDROGENASE (PS00069), a totally
conserved heptapeptide which contains the active lysine. Two iterations
on OWL25.1 were required to reach convergence, at which point a true set
comprising 24 sequences was identified.
An update on SPTR37_9f identified a true set of 57 sequences.
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| Sequence Titles | G6P1_MOUSE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE X (EC 1.1.1.49) (G6PD) - MUS MUSCULUS (MOUSE).
G6P2_MOUSE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE 2 (EC 1.1.1.49) (G6PD) - MUS MUSCULUS (MOUSE).
G6PC_SOLTU GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE, CHOLOROPLAST ISOFORM PRECURSOR (EC 1.1.1.49) (G6PD) - SOLANUM TUBEROSUM (POTATO).
G6PC_SPIOL GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE, CHOLOROPLAST ISOFORM PRECURSOR (EC 1.1.1.49) (G6PD) - SPINACIA OLERACEA (SPINACH).
G6PC_TOBAC GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE, CHOLOROPLAST ISOFORM PRECURSOR (EC 1.1.1.49) (G6PD) - NICOTIANA TABACUM (COMMON TOBACCO).
G6PD_ACTAC GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - ACTINOBACILLUS ACTINOMYCETEMCOMITANS (HAEMOPHILUS ACTINOMYCETEMCOMITANS).
G6PD_ANASP GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - ANABAENA SP. (STRAIN PCC 7120).
G6PD_ARATH GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE, CYTOPLASMIC ISOFORM (EC 1.1.1.49) (G6PD) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
G6PD_ASPNG GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - ASPERGILLUS NIGER.
G6PD_BACSU GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) (VEGETATIVE PROTEIN 11) (VEG11) - BACILLUS SUBTILIS.
G6PD_CAEEL GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - CAENORHABDITIS ELEGANS.
G6PD_CERCA GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) (ZWISCHENFERMENT) - CERATITIS CAPITATA (MEDITERRANEAN FRUIT FLY).
G6PD_DROME GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) (ZWISCHENFERMENT) - DROSOPHILA MELANOGASTER (FRUIT FLY).
G6PD_ECOLI GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - ESCHERICHIA COLI.
G6PD_EMENI GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
G6PD_ERWCH GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - ERWINIA CHRYSANTHEMI.
G6PD_FUGRU GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
G6PD_HAEIN GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - HAEMOPHILUS INFLUENZAE.
G6PD_HELPY GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
G6PD_HUMAN GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - HOMO SAPIENS (HUMAN).
G6PD_KLULA GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - KLUYVEROMYCES LACTIS (YEAST).
G6PD_LEUME GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - LEUCONOSTOC MESENTEROIDES.
G6PD_MACRO GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - MACROPUS ROBUSTUS (WALLAROO) (EURO).
G6PD_MEDSA GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE, CYTOPLASMIC ISOFORM (EC 1.1.1.49) (G6PD) - MEDICAGO SATIVA (ALFALFA).
G6PD_NOSPU GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - NOSTOC PUNCTIFORME.
G6PD_PICJA GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - PICHIA JADINII (YEAST) (CANDIDA UTILIS).
G6PD_RAT GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - RATTUS NORVEGICUS (RAT).
G6PD_SOLTU GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE, CYTOPLASMIC ISOFORM (EC 1.1.1.49) (G6PD) - SOLANUM TUBEROSUM (POTATO).
G6PD_SYNP7 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - SYNECHOCOCCUS SP. (STRAIN PCC 7942) (ANACYSTIS NIDULANS R2).
G6PD_SYNY3 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
G6PD_TREPA GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - TREPONEMA PALLIDUM.
G6PD_YEAST GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
G6PD_ZYMMO GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - ZYMOMONAS MOBILIS.
G6PE_RABIT GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE, ENDOPLASMIC (EC 1.1.1.49) - ORYCTOLAGUS CUNICULUS (RABBIT).
O06573 COSMID SCY22G8 - MYCOBACTERIUM TUBERCULOSIS.
O08407 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - MYCOBACTERIUM TUBERCULOSIS.
O14137 PUTATIVE GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE HOMOLOG - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O22404 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - PETROSELINUM CRISPUM (PARSLEY) (PETROSELINUM HORTENSE).
O22405 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - PETROSELINUM CRISPUM (PARSLEY) (PETROSELINUM HORTENSE).
O22406 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - PETROSELINUM CRISPUM (PARSLEY) (PETROSELINUM HORTENSE).
O48695 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O51581 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
O55044 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - CRICETULUS GRISEUS (CHINESE HAMSTER).
O57655 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
O59812 GLUCOSE-6-PHOSPHATE DEHYDROGENASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O65577 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O65854 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - NICOTIANA TABACUM (COMMON TOBACCO).
O65855 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - NICOTIANA TABACUM (COMMON TOBACCO).
O65856 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) PRECURSOR - NICOTIANA TABACUM (COMMON TOBACCO).
O66787 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE - AQUIFEX AEOLICUS.
O68282 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - PSEUDOMONAS AERUGINOSA.
O80525 F14J9.8 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O84188 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - CHLAMYDIA TRACHOMATIS.
O88017 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - STREPTOMYCES COELICOLOR.
P94684 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - CHLAMYDIA TRACHOMATIS.
Q25856 GLUCOSE-6-PHOSPHATE DEHYDROGENASE - PLASMODIUM FALCIPARUM.
Q27741 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD) - PLASMODIUM FALCIPARUM.
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