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PR00065

Identifier
TEADOMAIN  [View Relations]  [View Alignment]  
Accession
PR00065
No. of Motifs
3
Creation Date
20-JAN-1995  (UPDATE 12-FEB-2000)
Title
TEA domain signature
Database References

PROSITE; PS00554 TEA_DOMAIN
BLOCKS; BL00554
PFAM; PF01285 TEA
INTERPRO; IPR000818
Literature References
1. BUERGLIN, T.R.
The TEA domain: a novel, highly conserved DNA-binding motif.
CELL 66 11-12 (1991).

Documentation
The TEA domain is a DNA-binding region of 66-68 amino acids found in the
N-termini of certain gene regulatory proteins, such as the SV40 enhancer
factor TEF-1, yeast trans-acting factor TEC-1 (which is required for TY1
enhancer activity), and the Aspergillus abaA regulatory gene product [1].
SV40 and retroviral enhancers, and those to which TEF-1, TEC-1 and abaA
proteins bind, contain GT-IIC sites: the TEA domain may therefore recognise
and bind such sites [1].
 
Secondary structure predictions suggest the presence of 3 helices, but have
not confirmed the presence of the helix-turn-helix motif characteristic of
many DNA-binding proteins: DNA-binding may therefore be effected by a
different mechanism [1].
 
TEADOMAIN is a 3-element fingerprint that provides a signature for the 
DNA-binding TEA domain. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs were drawn from conserved regions
spanning the full domain length, motifs 2 and 3 encompassing the region
encoded by PROSITE pattern TEA_DOMAIN (PS00554). Two iterations on OWL25.1
were required to reach convergence, at which point a true set comprising
6 sequences was identified.
 
An update on SPTR37_10f identified a true set of 15 sequences.
Summary Information
15 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3151515
2000
123
True Positives
ABAA_EMENI    O70623        Q9Z0P8        SCAL_DROME    
TEC1_YEAST TEF1_HUMAN TEF1_MOUSE TEF3_CHICK
TEF3_HUMAN TEF3_MOUSE TEF4_MOUSE TEF5_CHICK
TEF5_HUMAN TEF5_MOUSE YUP2_CAEEL
Sequence Titles
ABAA_EMENI  REGULATORY PROTEIN ABAA - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS). 
O70623 TRANSCRIPTIONAL ENHANCER FACTOR TEF-5 (ETF-RELATED FACTOR-1) (ETFR-1) (TRANSCRIP
Q9Z0P8 TEF-5 PROTEIN - MUS MUSCULUS (MOUSE).
SCAL_DROME SCALLOPED PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
TEC1_YEAST TY TRANSCRIPTION ACTIVATOR TEC1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
TEF1_HUMAN TRANSCRIPTIONAL ENHANCER FACTOR TEF-1 (PROTEIN GT-IIC) (TRANSCRIPTION FACTOR 13)
TEF1_MOUSE TRANSCRIPTIONAL ENHANCER FACTOR TEF-1 (PROTEIN GT-IIC) (TRANSCRIPTION FACTOR 13)
TEF3_CHICK TRANSCRIPTIONAL ENHANCER FACTOR TEF-3 (TEF-1) (M-CAT BINDING FACTOR) (RTEF-1) -
TEF3_HUMAN TRANSCRIPTIONAL ENHANCER FACTOR TEF-3 (TRANSCRIPTION FACTOR RTEF-1) - HOMO SAPIE
TEF3_MOUSE TRANSCRIPTIONAL ENHANCER FACTOR TEF-3 (ETF-RELATED FACTOR-2) (ETFR- 2) (TEF-1-RE
TEF4_MOUSE TRANSCRIPTIONAL ENHANCER FACTOR TEF-4 (EMBRYONIC TEA DOMAIN-CONTAINING FACTOR) (
TEF5_CHICK TRANSCRIPTIONAL ENHANCER FACTOR TEF-5 (CARDIAC-ENRICHED TEA DOMAIN TRANSCRIPTION
TEF5_HUMAN TRANSCRIPTIONAL ENHANCER FACTOR TEF-5 (DTEF-1) - HOMO SAPIENS (HUMAN).
TEF5_MOUSE TRANSCRIPTIONAL ENHANCER FACTOR TEF-5 (ETF-RELATED FACTOR-1) (ETFR-1) (DTEF-1) -
YUP2_CAEEL HYPOTHETICAL 54.5 KD PROTEIN F28B12.2 IN CHROMOSOME II - CAENORHABDITIS ELEGANS.
Scan History
OWL25_1    2  100  NSINGLE    
SPTR37_9f 4 17 NSINGLE
SPTR37_10f 4 50 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
WSPDIEQSFQEALAI TEF1_MOUSE 35 35 -
WSPDIEQSFQEALAI TEF1_HUMAN 35 35 -
WSPDIEQSFQEALSI SCAL_DROME 93 93 -
WSDELEDAFQQALEA ABAA_EMENI 140 140 -
WSEKVEEAFLEALRL TEC1_YEAST 132 132 -

Motif 2 width=15
Element Seqn Id St Int Rpt
GRNELIARYIKLRTG TEF1_MOUSE 68 18 -
GRNELIARYIKLRTG TEF1_HUMAN 68 18 -
GRNELIARYIKLRTG SCAL_DROME 126 18 -
GRNELIAEYIYKLTG ABAA_EMENI 171 16 -
GRNELISLYIKHKTN TEC1_YEAST 163 16 -

Motif 3 width=15
Element Seqn Id St Int Rpt
KTRTRKQVSSHIQVL TEF1_MOUSE 83 0 -
KTRTRKQVSSHIQVL TEF1_HUMAN 83 0 -
KTRTRKQVSSHIQVL SCAL_DROME 141 0 -
KRRTRKQVSSHLQVL ABAA_EMENI 186 0 -
EFRTKKQISSHIQVW TEC1_YEAST 178 0 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
WSPDIEQSFQEALAI O70623 35 35 -
WSPDIEQSFQEALAI TEF5_MOUSE 35 35 -
WSPDIEQSFQEALAI TEF5_HUMAN 35 35 -
WSPDIEQSFQEALAI TEF4_MOUSE 45 45 -
WSPDIEQSFQEALAI TEF3_HUMAN 36 36 -
WSPDIEQSFQEALAI TEF3_CHICK 35 35 -
WSPDIEQSFQEALAI TEF1_MOUSE 35 35 -
WSPDIEQSFQEALAI TEF1_HUMAN 35 35 -
WSPDIEQSFQEALAI Q9Z0P8 35 35 -
WSPDIEQSFQEALSI SCAL_DROME 93 93 -
WSPDIEQSFQEALAI TEF5_CHICK 35 35 -
WSPEIERSFQEALAI TEF3_MOUSE 36 36 -
WSIDIDQAFQEALAI YUP2_CAEEL 111 111 -
WSDELEDAFQQALEA ABAA_EMENI 140 140 -
WSEKVEEAFLEALRL TEC1_YEAST 132 132 -

Motif 2 width=15
Element Seqn Id St Int Rpt
GRNELIARYIKLRTG O70623 68 18 -
GRNELIARYIKLRTG TEF5_MOUSE 68 18 -
GRNELIARYIKLRTG TEF5_HUMAN 68 18 -
GRNELIARYIKLRTG TEF4_MOUSE 78 18 -
GRNELIARYIKLRTG TEF3_HUMAN 69 18 -
GRNELIARYIKLRTG TEF3_CHICK 68 18 -
GRNELIARYIKLRTG TEF1_MOUSE 68 18 -
GRNELIARYIKLRTG TEF1_HUMAN 68 18 -
GRNELIARYIKLRTG Q9Z0P8 68 18 -
GRNELIARYIKLRTG SCAL_DROME 126 18 -
GRNELIARYIKLRTG TEF5_CHICK 68 18 -
GRNELIARHIKLRTG TEF3_MOUSE 69 18 -
GRNELIARYIKLRCG YUP2_CAEEL 144 18 -
GRNELIAEYIYKLTG ABAA_EMENI 171 16 -
GRNELISLYIKHKTN TEC1_YEAST 163 16 -

Motif 3 width=15
Element Seqn Id St Int Rpt
KTRTRKQVSSHIQVL O70623 83 0 -
KTRTRKQVSSHIQVL TEF5_MOUSE 83 0 -
KTRTRKQVSSHIQVL TEF5_HUMAN 83 0 -
KTRTRKQVSSHIQVL TEF4_MOUSE 93 0 -
KTRTRKQVSSHIQVL TEF3_HUMAN 84 0 -
KTRTRKQVSSHIQVL TEF3_CHICK 83 0 -
KTRTRKQVSSHIQVL TEF1_MOUSE 83 0 -
KTRTRKQVSSHIQVL TEF1_HUMAN 83 0 -
KTRTRKQVSSHIQVL Q9Z0P8 83 0 -
KTRTRKQVSSHIQVL SCAL_DROME 141 0 -
KTRTKKQVSSHLQVL TEF5_CHICK 83 0 -
KTRTRKQVSSHIQVL TEF3_MOUSE 84 0 -
KTRTRKQVSSHIQVL YUP2_CAEEL 159 0 -
KRRTRKQVSSHLQVL ABAA_EMENI 186 0 -
EFRTKKQISSHIQVW TEC1_YEAST 178 0 -