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PR00031

Identifier
HTHREPRESSR  [View Relations]  [View Alignment]  
Accession
PR00031
No. of Motifs
2
Creation Date
23-MAR-1993  (UPDATE 20-JUN-1999)
Title
Lambda and other repressor helix-turn-helix signature
Database References

INTERPRO; IPR000047
PDB; 1PRA
SCOP; 1PRA
CATH; 1PRA
Literature References
1. BRENNAN, R.G. AND  MATTHEWS, B.W.
The helix-turn-helix DNA binding motif.
J.BIOL.CHEM. 264 1903-1906 (1989).
 
2. SAUER, R.T.,YOCUM, R.R., DOOLITTLE, R.F., LEWIS, M. AND PABO, C.O.
Homology among DNA-binding proteins suggests use of a conserved super-
secondary structure.
NATURE 298 447-451 (1982)
 
3. PABO, C.O. AND SAUER, R.T.
Protein-DNA recognition.
ANNU.REV.BIOCHEMISTRY 53 293-321 (1984).

Documentation
Helix-turn-helix (HTH) motifs are found in all known DNA binding proteins
that regulate gene expression. The motif consists of approximately 20 
residues and is characterised by 2 alpha-helices, which make intimate 
contacts with the DNA and are joined by a short turn. The second helix of 
the HTH motif binds to DNA via a number of hydrogen bonds and hydrophobic 
interactions, which occur between specific side chains and the exposed 
bases and thymine methyl groups within the major groove of the DNA [1]. The
first helix helps to stabilise the structure [2]. 
 
The HTH motif is very similar in sequence and structure to the N-terminal 
region of the lamda [3] and other repressor proteins, and has also been 
identified in many other DNA-binding proteins on the basis of sequence and 
structural similarity [1]. One of the principal differences between HTH 
motifs in these different proteins arises from the stereochemical 
requirement for glycine in the turn, which is needed to avoid steric 
interference of the beta-carbon with the main chain: for cro and other 
repressors the Gly appears to be mandatory, while for many of the homeotic
and other DNA-binding proteins the requirement is relaxed. 
 
HTHREPRESSR is a 2-element fingerprint that provides a signature for the HTH
motif of lambda and other repressors, and various homeotic proteins. The
fingerprint was derived from an initial alignment of 20 sequences (after
Brennan and Matthews [1]): the motifs span the complete motif and hinge on
the conserved glycine, differing from the equivalent cro motifs in terms of
the number and distribution of charged and aromatic residues. Four
iterations on OWL19.1 were required to reach convergence, at which point a
true set comprising 102 sequences was identified. This set includes
repressor proteins, an atypical cro sequence, RNA polymerase sigma factors,
homeotic proteins, etc., all of which have Gly conserved in the turn. 
 
An update on SPTR37_9f identified a true set of 103 sequences.
Summary Information
103 codes involving  2 elements
Composite Feature Index
2103103
12
True Positives
ATH5_ARATH    ATH6_ARATH    CDX1_HUMAN    CDX1_MOUSE    
CDX2_HUMAN CDX2_MESAU CDX2_MOUSE CDX4_HUMAN
CDX4_MOUSE DBX_MOUSE DLX1_BRARE DLX1_MOUSE
DLX2_BRARE DLX2_HUMAN DLX2_MOUSE DLX3_AMBME
DLX3_BRARE DLX3_HUMAN DLX3_MOUSE DLX3_NOTVI
DLX3_PLEWA DLX4_BRARE DLX5_BRARE DLX5_CHICK
DLX5_MOUSE DLX5_RAT DLX6_BRARE DLX7_BRARE
DLX7_MOUSE DLX8_BRARE EXD_DROME FX24_RHILV
GSBD_DROME HAT1_ARATH HAT4_ARATH HAT5_ARATH
HAT7_ARATH HLX1_HUMAN HLX1_MOUSE HM16_CAEEL
HM23_CAEEL HMCU_DROME HMD1_CAEEL HMD1_CHICK
HMD1_XENLA HMD2_XENLA HMD3_XENLA HMD4_XENLA
HMDL_BRAFL HMDL_DROME HME1_BRARE HME2_BRARE
HME2_CHICK HME3_BRARE HMED_XENLA HMEN_ARTSF
HMEN_BOMMO HMIN_BOMMO HX1A_MAIZE MTA0_YEAST
MTA1_YEAST O08686 O17588 O32725
O43518 O43812 O46118 O54817
O57407 O86069 O88933 O93236
O93534 P79788 P91625 PBX1_HUMAN
PBX1_MOUSE PBX2_HUMAN PBX2_MOUSE Q04787
Q06453 Q14333 Q17243 Q21169
Q39862 Q39941 Q40782 Q41812
Q43425 Q43427 Q43428 Q43529
Q52775 Q90262 Q90320 Q90881
Q91622 RPSF_BACLI RPSF_BACME RPSF_BACSU
RPSG_CLOAB SIX1_HUMAN SIX2_MOUSE
Sequence Titles
ATH5_ARATH  HOMEOBOX-LEUCINE ZIPPER PROTEIN ATHB-5 (HD-ZIP PROTEIN ATHB-5) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS). 
ATH6_ARATH HOMEOBOX-LEUCINE ZIPPER PROTEIN ATHB-6 (HD-ZIP PROTEIN ATHB-6) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
CDX1_HUMAN HOMEOBOX PROTEIN CDX-1 (CAUDAL-TYPE HOMEOBOX PROTEIN 1) - HOMO SAPIENS (HUMAN).
CDX1_MOUSE HOMEOBOX PROTEIN CDX-1 (CAUDAL-TYPE HOMEOBOX PROTEIN 1) - MUS MUSCULUS (MOUSE).
CDX2_HUMAN HOMEOBOX PROTEIN CDX-2 (CAUDAL-TYPE HOMEOBOX PROTEIN 2) (CDX-3) - HOMO SAPIENS (HUMAN).
CDX2_MESAU HOMEOBOX PROTEIN CDX-2 (CAUDAL-TYPE HOMEOBOX PROTEIN 2) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
CDX2_MOUSE HOMEOBOX PROTEIN CDX-2 (CAUDAL-TYPE HOMEOBOX PROTEIN 2) - MUS MUSCULUS (MOUSE).
CDX4_HUMAN HOMEOBOX PROTEIN CDX-4 (CAUDAL-TYPE HOMEOBOX PROTEIN 4) - HOMO SAPIENS (HUMAN).
CDX4_MOUSE HOMEOBOX PROTEIN CDX-4 (CAUDAL-TYPE HOMEOBOX PROTEIN 4) - MUS MUSCULUS (MOUSE).
DBX_MOUSE HOMEOBOX PROTEIN DBX - MUS MUSCULUS (MOUSE).
DLX1_BRARE HOMEOBOX PROTEIN DLX-1 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
DLX1_MOUSE HOMEOBOX PROTEIN DLX-1 - MUS MUSCULUS (MOUSE).
DLX2_BRARE HOMEOBOX PROTEIN DLX-2 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
DLX2_HUMAN HOMEOBOX PROTEIN DLX-2 - HOMO SAPIENS (HUMAN).
DLX2_MOUSE HOMEOBOX PROTEIN DLX-2 (HOMEOBOX PROTEIN TES-1) - MUS MUSCULUS (MOUSE).
DLX3_AMBME HOMEOBOX PROTEIN DLX-3 - AMBYSTOMA MEXICANUM (AXOLOTL).
DLX3_BRARE HOMEOBOX PROTEIN DLX-3 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
DLX3_HUMAN HOMEOBOX PROTEIN DLX-3 - HOMO SAPIENS (HUMAN).
DLX3_MOUSE HOMEOBOX PROTEIN DLX-3 - MUS MUSCULUS (MOUSE).
DLX3_NOTVI HOMEOBOX PROTEIN DLX-3 (BOX-4) (NVHBOX-4) - NOTOPHTHALMUS VIRIDESCENS (EASTERN NEWT) (TRITURUS VIRIDESCENS).
DLX3_PLEWA DISTAL-LESS LIKE PROTEIN DLX-3 - PLEURODELES WALTLII (IBERIAN RIBBED NEWT).
DLX4_BRARE HOMEOBOX PROTEIN DLX-4 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
DLX5_BRARE HOMEOBOX PROTEIN DLX-5 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
DLX5_CHICK HOMEOBOX PROTEIN DLX-5 - GALLUS GALLUS (CHICKEN).
DLX5_MOUSE HOMEOBOX PROTEIN DLX-5 - MUS MUSCULUS (MOUSE).
DLX5_RAT HOMEOBOX PROTEIN DLX-5 (DLX-3) (RDLX) - RATTUS NORVEGICUS (RAT).
DLX6_BRARE HOMEOBOX PROTEIN DLX-6 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
DLX7_BRARE HOMEOBOX PROTEIN DLX-7 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
DLX7_MOUSE HOMEOBOX PROTEIN DLX-7 - MUS MUSCULUS (MOUSE).
DLX8_BRARE HOMEOBOX PROTEIN DLX-8 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
EXD_DROME HOMEOBOX PROTEIN EXTRADENTICLE - DROSOPHILA MELANOGASTER (FRUIT FLY).
FX24_RHILV PROBABLE TRANSCRIPTIONAL ACTIVATOR (ORF-240) - RHIZOBIUM LEGUMINOSARUM (BIOVAR VICIAE).
GSBD_DROME GOOSEBERRY DISTAL PROTEIN (BSH9) - DROSOPHILA MELANOGASTER (FRUIT FLY).
HAT1_ARATH HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT1 (HD-ZIP PROTEIN 1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
HAT4_ARATH HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT4 (HD-ZIP PROTEIN 4) (HD-ZIP PROTEIN ATHB-2) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
HAT5_ARATH HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT5 (HD-ZIP PROTEIN 5) (HD-ZIP PROTEIN ATHB-1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
HAT7_ARATH HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT7 (HD-ZIP PROTEIN 7) (HD-ZIP PROTEIN ATHB-3) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
HLX1_HUMAN HOMEOBOX PROTEIN HLX1 (HOMEOBOX PROTEIN HB24) - HOMO SAPIENS (HUMAN).
HLX1_MOUSE HOMEOBOX PROTEIN HLX1 - MUS MUSCULUS (MOUSE).
HM16_CAEEL HOMEOBOX PROTEIN ENGRAILED-LIKE CEH-16 - CAENORHABDITIS ELEGANS.
HM23_CAEEL HOMEOBOX PROTEIN CEH-23 - CAENORHABDITIS ELEGANS.
HMCU_DROME HOMEOBOX PROTEIN CUT - DROSOPHILA MELANOGASTER (FRUIT FLY).
HMD1_CAEEL PUTATIVE HOMEOBOX PROTEIN C28A5.4 - CAENORHABDITIS ELEGANS.
HMD1_CHICK HOMEOBOX PROTEIN CHOX-CAD - GALLUS GALLUS (CHICKEN).
HMD1_XENLA HOMEOBOX PROTEIN DLL-1 (DLL) (XDLL) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HMD2_XENLA HOMEOBOX PROTEIN DLL-2 (XDLL-2) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HMD3_XENLA HOMEOBOX PROTEIN DLL-3 (XDLL-3) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HMD4_XENLA HOMEOBOX PROTEIN DLL-4 (XDLL-4) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HMDL_BRAFL HOMEOBOX PROTEIN DLL HOMOLOG - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
HMDL_DROME HOMEOTIC DISTAL-LESS PROTEIN (PROTEIN BRISTA) - DROSOPHILA MELANOGASTER (FRUIT FLY).
HME1_BRARE HOMEOBOX PROTEIN ENGRAILED-1 - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
HME2_BRARE HOMEOBOX PROTEIN ENGRAILED-2 (ZF-EN-2) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
HME2_CHICK HOMEOBOX PROTEIN ENGRAILED-2 (GG-EN-2) - GALLUS GALLUS (CHICKEN).
HME3_BRARE HOMEOBOX PROTEIN ENGRAILED-3 (ZF-EN-1) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
HMED_XENLA HOMEOBOX PROTEIN ENGRAILED-2B (EN-2B) (EN2 MABEN) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
HMEN_ARTSF HOMEOBOX PROTEIN ENGRAILED - ARTEMIA SANFRANCISCANA (BRINE SHRIMP) (ARTEMIA FRANCISCANA).
HMEN_BOMMO SEGMENTATION POLARITY HOMEOBOX PROTEIN ENGRAILED - BOMBYX MORI (SILK MOTH).
HMIN_BOMMO HOMEOBOX PROTEIN INVECTED - BOMBYX MORI (SILK MOTH).
HX1A_MAIZE HOMEOBOX PROTEIN HOX1A - ZEA MAYS (MAIZE).
MTA0_YEAST MATING-TYPE PROTEIN A-1, INCOMPLETELY SPLICED - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
MTA1_YEAST MATING-TYPE PROTEIN A-1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O08686 BARX2 - MUS MUSCULUS (MOUSE).
O17588 C16C2.1 PROTEIN - CAENORHABDITIS ELEGANS.
O32725 RNA POLYMERASE SIGMA FACTOR - BACILLUS SPHAERICUS.
O43518 BARX2 - HOMO SAPIENS (HUMAN).
O43812 DUX1 PROTEIN - HOMO SAPIENS (HUMAN).
O46118 DNA-BINDING PROTEIN - DUGESIA TIGRINA (PLANARIAN).
O54817 EXTRAEMBRYONIC, SPERMATOGENESIS, HOMEOBOX 1 (PAIRED-LIKE HOMEODOMAIN CONTAINING PROTEIN) - MUS MUSCULUS (MOUSE).
O57407 HOMEOBOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O86069 FNR-TYPE TRANSCRIPTIONAL REGULATOR FNRND - RHIZOBIUM ETLI.
O88933 HOMEOBOX PROTEIN SPX1 - MUS MUSCULUS (MOUSE).
O93236 DHARMA - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O93534 HOMEOBOX PROTEIN BIX2 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P79788 HOMEOBOX PROTEIN - GALLUS GALLUS (CHICKEN).
P91625 LADYBIRD EARLY HOMEODOMAIN TRANSCRIPTION FACTOR - DROSOPHILA MELANOGASTER (FRUIT FLY).
PBX1_HUMAN PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-1 (HOMEOBOX PROTEIN PBX1) (HOMEOBOX PROTEIN PRL) - HOMO SAPIENS (HUMAN).
PBX1_MOUSE PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-1 (HOMEOBOX PROTEIN PBX1) - MUS MUSCULUS (MOUSE).
PBX2_HUMAN PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-2 (HOMEOBOX PROTEIN PBX2) (G17) - HOMO SAPIENS (HUMAN).
PBX2_MOUSE PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-2 (HOMEOBOX PROTEIN PBX2) - MUS MUSCULUS (MOUSE).
Q04787 BRAIN-SPECIFIC HOMEOBOX PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q06453 HOMEOBOX PROTEIN ARISTALESS - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q14333 FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD) GENE REGION, D4Z4 TANDEM REPEAT UNIT (FSHD) - HOMO SAPIENS (HUMAN).
Q17243 CAD PROTEIN - BOMBYX MORI (SILK MOTH).
Q21169 K03A11.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q39862 HOMEOBOX-LEUCINE ZIPPER PROTEIN - GLYCINE MAX (SOYBEAN).
Q39941 HOMEODOMAIN CONTAINING PROTEIN (HAHB-1) - HELIANTHUS ANNUUS (COMMON SUNFLOWER).
Q40782 HOMEOBOX-LEUCINE ZIPPER PROTEIN - PIMPINELLA BRACHYCARPA.
Q41812 HOMEOBOX 2A PROTEIN - ZEA MAYS (MAIZE).
Q43425 DNA-BINDING PROTEIN - DAUCUS CAROTA (CARROT).
Q43427 DNA-BINDING PROTEIN - DAUCUS CAROTA (CARROT).
Q43428 DNA-BINDING PROTEIN - DAUCUS CAROTA (CARROT).
Q43529 HOMEOBOX - LYCOPERSICON ESCULENTUM (TOMATO).
Q52775 FNRN - RHIZOBIUM LEGUMINOSARUM.
Q90262 ZF-CAD1 PROTEIN - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
Q90320 CAUDAL HOMOLOG CDX1 - CYPRINUS CARPIO (COMMON CARP).
Q90881 HOMEOBOX PROTEIN - GALLUS GALLUS (CHICKEN).
Q91622 XCAD2 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
RPSF_BACLI RNA POLYMERASE SIGMA-F FACTOR (STAGE II SPORULATION PROTEIN AC) (SPORULATION SIGMA FACTOR) - BACILLUS LICHENIFORMIS.
RPSF_BACME RNA POLYMERASE SIGMA-F FACTOR (STAGE II SPORULATION PROTEIN AC) (SPORULATION SIGMA FACTOR) - BACILLUS MEGATERIUM.
RPSF_BACSU RNA POLYMERASE SIGMA-F FACTOR (STAGE II SPORULATION PROTEIN AC) (SPORULATION SIGMA FACTOR) - BACILLUS SUBTILIS.
RPSG_CLOAB RNA POLYMERASE SIGMA-G FACTOR - CLOSTRIDIUM ACETOBUTYLICUM.
SIX1_HUMAN HOMEOBOX PROTEIN SIX1 - HOMO SAPIENS (HUMAN).
SIX2_MOUSE HOMEOBOX PROTEIN SIX2 - MUS MUSCULUS (MOUSE).
Scan History
OWL19_1    4  500  NSINGLE    
OWL26_0 1 900 NSINGLE
SPTR37_9f 1 850 NSINGLE
Initial Motifs
Motif 1  width=10
Element Seqn Id St Int Rpt
TQRAVAKALG P09964 11 11 -
GQRKVADALG P03041 24 24 -
NQAELAQKVG RPC1_BP434 15 15 -
GQTKTAKDLG RCRO_LAMBD 14 14 -
SQESVADKMG P03034 31 31 -
GQTKTAKDLG N_4CROE 12 12 -
LVAAVADKAG DBH_RHIME 5 5 -
TLYDVAEYAG LACI_ECOLI 4 4 -
GTEKTAEAVG P03042 24 24 -
SRQQLADLTG P04132 18 18 -
TIKDVARLAG GALR_ECOLI 2 2 -
NKKQLADIFG VNU1_LAMBD 3 3 -
SQRELKNELG P03032 65 65 -
RQAALGKMVG P03035 19 19 -
SGEQLGETLG P06709 20 20 -
TQTELATKAG N_2CRO 17 17 -
EKEEVAKKCG MTA0_YEAST 98 98 -
TQTELATKAG RCRO_BP434 17 17 -

Motif 2 width=17
Element Seqn Id St Int Rpt
GITPLQVRVWVCNMRIK MTA0_YEAST 107 -1 -
GVKQQSIQLIEAGVTKR RCRO_BP434 26 -1 -
GVKQQSIQLIEAGVTKR N_2CRO 26 -1 -
GISDAAVSQWKEVIPEK P09964 20 -1 -
GINESQISRWKGDFIPK P03041 33 -1 -
GTTQQSIEQLENGKTKR RPC1_BP434 24 -1 -
GVYQSAINKAIHAGRKI RCRO_LAMBD 23 -1 -
GMGQSGVGALFNGINAL P03034 40 -1 -
GVYQSAINKAIHAGRKI N_4CROE 21 -1 -
GLSKADASSAVDAVFET DBH_RHIME 14 -1 -
GVSYQTVSRVVNQASHV LACI_ECOLI 13 -1 -
GVDKSQISRWKRDWIPK P03042 33 -1 -
GVPYGTLSYYESGRSTP P04132 27 -1 -
GVSVATVSRVINNSPKA GALR_ECOLI 11 -1 -
GASIRTIQNWQEQGMPV VNU1_LAMBD 12 -1 -
GAGIATITRGSNSLKAA P03032 74 -1 -
GVSNVAISQWERSETEP P03035 28 -1 -
GMSRAAINKHIQTLRDW P06709 29 -1 -
Final Motifs
Motif 1  width=10
Element Seqn Id St Int Rpt
ERAELAASLG DLX2_BRARE 152 152 -
ERAELAASLG HMDL_DROME 153 153 -
ERAELAASLG DLX5_BRARE 154 154 -
ERAELAASLG DLX2_MOUSE 184 184 -
ERAELAASLG DLX2_HUMAN 181 181 -
ERAELAASLG DLX1_BRARE 157 157 -
ERAELAASLG HMD3_XENLA 166 166 -
ERAELAASLG DLX6_BRARE 154 154 -
ERAELAASLG DLX5_RAT 166 166 -
ERAELAASLG DLX5_MOUSE 166 166 -
ERAELAASLG DLX5_CHICK 165 165 -
ERAELAASLG DLX4_BRARE 166 166 -
ERAELAASLG DLX1_MOUSE 157 157 -
ERAELAAQLG DLX3_AMBME 155 155 -
ERAELAAQLG DLX3_BRARE 154 154 -
ERAELAAQLG DLX3_HUMAN 158 158 -
ERAELAAQLG DLX3_MOUSE 158 158 -
ERAELAAQLG DLX3_NOTVI 154 154 -
ERAELAAQLG DLX3_PLEWA 155 155 -
ERAELAAQLG HMD2_XENLA 159 159 -
ERAELAAQLG HMDL_BRAFL 145 145 -
RKAELAAALG HMD1_CHICK 166 166 -
RKAELAAALG Q91622 179 179 -
RKAELAATLG CDX2_HUMAN 213 213 -
RKAELAATLG CDX2_MESAU 214 214 -
ERAELAASLG HMD4_XENLA 156 156 -
ERAELAASLG HMD1_XENLA 154 154 -
RKSELAANLG CDX1_HUMAN 183 183 -
RKSELAANLG CDX1_MOUSE 183 183 -
RKAELAVSLG Q17243 149 149 -
RKAELASSLG P79788 207 207 -
RKSELAATLG CDX2_MOUSE 214 214 -
ERADLAAKLG DLX7_BRARE 158 158 -
ERADLAAKLG DLX8_BRARE 152 152 -
EREELAQCLG Q21169 154 154 -
RKSELAVNLG CDX4_HUMAN 202 202 -
RKSELAVNLG Q90320 180 180 -
RKSELAVNLG Q90262 180 180 -
RKSELAVNLG CDX4_MOUSE 200 200 -
ERAQLAAQLG DLX7_MOUSE 145 145 -
RRQELAHELG HM16_CAEEL 132 132 -
ERVELATALG Q04787 161 161 -
DRAALAHELG HMD1_CAEEL 131 131 -
RRQSLAQELG HMED_XENLA 205 205 -
RRQSLAQELG HME2_CHICK 228 228 -
RRQSLAQELG HME2_BRARE 205 205 -
RRQSLAAELG HMEN_BOMMO 309 309 -
RRQSLAAELG HMIN_BOMMO 401 401 -
RRQALAQELG HME3_BRARE 201 201 -
RRQALARELG HME1_BRARE 172 172 -
ERENLAQRLG HM23_CAEEL 240 240 -
TRAKLAESLG O17588 64 64 -
DRKQLAAMLG HLX1_MOUSE 302 302 -
DRKQLAAMLG HLX1_HUMAN 305 305 -
RKLELARALG Q43428 126 126 -
DRKKLASKLG DBX_MOUSE 210 210 -
RRQDLARELG HMEN_ARTSF 278 278 -
RKVQLAKELG Q43427 66 66 -
RKVKLAQELG ATH5_ARATH 98 98 -
TREELAMKIG Q06453 114 114 -
QKLALAKKLG HAT1_ARATH 161 161 -
RKTQLAKKLG HAT5_ARATH 94 94 -
DRLDLAQSLG O08686 141 141 -
DRLDLAQSLG O43518 137 137 -
RKVKLAQELG ATH6_ARATH 88 88 -
RKVQLAKDLG Q43425 115 115 -
TRAELAQNTG O93236 144 144 -
RKVQLAKELG Q43529 116 116 -
TREELAQSTG GSBD_DROME 214 214 -
RKMQLAKALG HAT7_ARATH 78 78 -
AKEELAKKCG PBX1_HUMAN 265 265 -
AKEELAKKCG PBX1_MOUSE 265 265 -
AKEELAKKCG PBX2_HUMAN 276 276 -
AKEELAKKCG PBX2_MOUSE 276 276 -
RKMQLARALG Q39941 118 118 -
AKEELARKCG EXD_DROME 270 270 -
SRESLARSLG O46118 186 186 -
QKQALAKQLG HAT4_ARATH 155 155 -
ARVELARRLG O54817 147 147 -
ARVELARRLG O88933 215 215 -
QKLALAKRLG Q40782 165 165 -
QKLALAKQLG Q39862 140 140 -
AREELARETG Q14333 585 585 -
AREELARETG O43812 123 123 -
EKRELAEATG SIX1_HUMAN 153 153 -
EKRELAEATG SIX2_MOUSE 153 153 -
QREELARQMG O57407 112 112 -
QREELARQMG O93534 112 112 -
SYTELAAKSG Q90881 181 181 -
DRDEIAASLG P91625 382 382 -
EKEEVAKKCG MTA1_YEAST 99 99 -
VKESLAEELG HX1A_MAIZE 588 588 -
TKESLAQELG Q41812 1063 1063 -
EKEEVAKKCG MTA0_YEAST 98 98 -
TQSEVAARLG RPSF_BACME 220 220 -
TQSEVADRLG RPSF_BACLI 220 220 -
SRAEIADFLG O86069 190 190 -
SRAEIADFLG Q52775 190 190 -
SRAEIADFLG FX24_RHILV 190 190 -
TIEFLANELG HMCU_DROME 1774 1774 -
TQSEVAERLG RPSF_BACSU 220 220 -
TIQELAQVLG O32725 134 134 -
TQMEVADEIG RPSG_CLOAB 227 227 -

Motif 2 width=17
Element Seqn Id St Int Rpt
GLTQTQVKIWFQNRRSK DLX2_BRARE 161 -1 -
GLTQTQVKIWFQNRRSK HMDL_DROME 162 -1 -
GLTQTQVKIWFQNRRSK DLX5_BRARE 163 -1 -
GLTQTQVKIWFQNRRSK DLX2_MOUSE 193 -1 -
GLTQTQVKIWFQNRRSK DLX2_HUMAN 190 -1 -
GLTQTQVKIWFQNKRSK DLX1_BRARE 166 -1 -
GLTQTQVKIWFQNKRSK HMD3_XENLA 175 -1 -
GLTQTQVKIWFQNKRSK DLX6_BRARE 163 -1 -
GLTQTQVKIWFQNKRSK DLX5_RAT 175 -1 -
GLTQTQVKIWFQNKRSK DLX5_MOUSE 175 -1 -
GLTQTQVKIWFQNKRSK DLX5_CHICK 174 -1 -
GLTQTQVKIWFQNKRSK DLX4_BRARE 175 -1 -
GLTQTQVKIWFQNKRSK DLX1_MOUSE 166 -1 -
GLTQTQVKIWFQNRRSK DLX3_AMBME 164 -1 -
GLTQTQVKIWFQNRRSK DLX3_BRARE 163 -1 -
GLTQTQVKIWFQNRRSK DLX3_HUMAN 167 -1 -
GLTQTQVKIWFQNRRSK DLX3_MOUSE 167 -1 -
GLTQTQVKIWFQNRRSK DLX3_NOTVI 163 -1 -
GLTQTQVKIWFQNRRSK DLX3_PLEWA 164 -1 -
GLTQTQVKIWFQNRRSK HMD2_XENLA 168 -1 -
GLTQTQVKIWFQNRRSK HMDL_BRAFL 154 -1 -
GLTERQVKIWFQNRRAK HMD1_CHICK 175 -1 -
GLTERQVKIWFQNRRAK Q91622 188 -1 -
GLSERQVKIWFQNRRAK CDX2_HUMAN 222 -1 -
GLSERQVKIWFQNRRAK CDX2_MESAU 223 -1 -
GVTQTQVKIWFQNRRSK HMD4_XENLA 165 -1 -
GVTQTQVKIWFQNKRSK HMD1_XENLA 163 -1 -
GLTERQVKIWFQNRRAK CDX1_HUMAN 192 -1 -
GLTERQVKIWFQNRRAK CDX1_MOUSE 192 -1 -
GLSERQVKIWFQNRRAK Q17243 158 -1 -
GLSERQVKIWFQNRRAK P79788 216 -1 -
GLSERQVKIWFQNRRAK CDX2_MOUSE 223 -1 -
GLTQTQVKIWFQNKRSK DLX7_BRARE 167 -1 -
GLTQTQVKIWFQNKRSK DLX8_BRARE 161 -1 -
GLTATQVKIWFQNRRYK Q21169 163 -1 -
GLSERQVKIWFQNRRAK CDX4_HUMAN 211 -1 -
GLSERQVKIWFQNRRAK Q90320 189 -1 -
GLSERQVKIWFQNRRAK Q90262 189 -1 -
GLSERQVKIWFQNRRAK CDX4_MOUSE 209 -1 -
GLTQTQVKIWFQNKRSK DLX7_MOUSE 154 -1 -
GLNESQIKIWFQNKRAK HM16_CAEEL 141 -1 -
GLSETQVKTWFQNRRMK Q04787 170 -1 -
GLSQTQVKIWFQNRRSK HMD1_CAEEL 140 -1 -
GLNESQIKIWFQNKRAK HMED_XENLA 214 -1 -
GLNESQIKIWFQNKRAK HME2_CHICK 237 -1 -
GLNESQIKIWFQNKRAK HME2_BRARE 214 -1 -
GLAEAQIKIWFQNKRAK HMEN_BOMMO 318 -1 -
GLAEAQIKIWFQNKRAK HMIN_BOMMO 410 -1 -
GLNESQIKIWFQNKRAK HME3_BRARE 210 -1 -
GLNESQIKIWFQNKRAK HME1_BRARE 181 -1 -
GLSPSQVRIWFQNRRSK HM23_CAEEL 249 -1 -
GLSDNQVKVWFQNRRTK O17588 73 -1 -
GLTDAQVKVWFQNRRMK HLX1_MOUSE 311 -1 -
GLTDAQVKVWFQNRRMK HLX1_HUMAN 314 -1 -
GLQPRQIAIWFQNRRAR Q43428 135 -1 -
GLKDSQVKIWFQNRRMK DBX_MOUSE 219 -1 -
GLHENQIKIWFQNNRAK HMEN_ARTSF 287 -1 -
GLQPRQVAIWFQNRRAR Q43427 75 -1 -
GLQPRQVAIWFQNRRAR ATH5_ARATH 107 -1 -
GLTEARIQVWFQNRRAK Q06453 123 -1 -
GLTARQVEVWFQNRRAR HAT1_ARATH 170 -1 -
GLQPRQVAVWFQNRRAR HAT5_ARATH 103 -1 -
GLTQLQVKTWYQNRRMK O08686 150 -1 -
GLTQLQVKTWYQNRRMK O43518 146 -1 -
GLQPRQVAVWFQNRRAR ATH6_ARATH 97 -1 -
GLQPRQVAIWFQNRRAR Q43425 124 -1 -
GLSEETVRVWFKNRRAR O93236 153 -1 -
GLQPRQIAIWFQNRRAR Q43529 125 -1 -
GLTEARVQVWFSNRRAR GSBD_DROME 223 -1 -
GLQPRQIAIWFQNRRAR HAT7_ARATH 87 -1 -
GITVSQVSNWFGNKRIR PBX1_HUMAN 274 -1 -
GITVSQVSNWFGNKRIR PBX1_MOUSE 274 -1 -
GITVSQVSNWFGNKRIR PBX2_HUMAN 285 -1 -
GITVSQVSNWFGNKRIR PBX2_MOUSE 285 -1 -
GLQPRQIAIWFQNRRAR Q39941 127 -1 -
GITVSQVSNWFGNKRIR EXD_DROME 279 -1 -
GLPESRVQVWFQNRRAK O46118 195 -1 -
GLRARQVEVWFQNRRAR HAT4_ARATH 164 -1 -
GLPEPRVQVWFQNRRAK O54817 156 -1 -
GLPEPRVQVWFQNRRAK O88933 224 -1 -
GLRPRQVEVWFQNRRAR Q40782 174 -1 -
GLRARQVEVWFQNRRAR Q39862 149 -1 -
GLPESRIQIWFQNRRAR Q14333 594 -1 -
GLPESRIQIWFQNRRAR O43812 132 -1 -
GLTTTQVSNWFKNRRQR SIX1_HUMAN 162 -1 -
GLTTTQVSNWFKNRRQR SIX2_MOUSE 162 -1 -
GLPESRIQVWFQNRRSK O57407 121 -1 -
GLPESRIQVWFQNRRSK O93534 121 -1 -
GLTKRVLQVWFQNARAK Q90881 286 95 -
GLSNAQVITWFQNRRAK P91625 391 -1 -
GITPLQVRVWFINKRMR MTA1_YEAST 108 -1 -
GLTFRQVNKWFETRRHS HX1A_MAIZE 597 -1 -
GLTFNQISKWFSGTRHY Q41812 1072 -1 -
GITPLQVRVWVCNMRIK MTA0_YEAST 107 -1 -
GISQVQVSRLEKKILKQ RPSF_BACME 229 -1 -
GISQVQVSRLEKKILKQ RPSF_BACLI 229 -1 -
GLTIETVSRQLTRLRKE O86069 199 -1 -
GLTIETVSRQMTRLRKS Q52775 199 -1 -
GLTIETVSRQMTRLRKI FX24_RHILV 199 -1 -
GLATRTITNWFHNHRMR HMCU_DROME 1783 -1 -
GISQVQVSRLEKKILKQ RPSF_BACSU 229 -1 -
GISQVQVSRLEKKILAQ O32725 227 83 -
GISQAQVSRLEKTALKH RPSG_CLOAB 236 -1 -