SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR00018

Identifier
KRINGLE  [View Relations]  [View Alignment]  
Accession
PR00018
No. of Motifs
4
Creation Date
08-JUL-1991  (UPDATE 28-JUL-1999)
Title
Kringle domain signature     
Database References

PROSITE; PS00021 KRINGLE
BLOCKS; BL00021
PFAM; PF00051 kringle
INTERPRO; IPR000001
PDB; 1TPK
SCOP; 1TPK
CATH; 1TPK
Literature References
1. MCMULLEN, B.A. AND FUJIKAWA, K.
Primary structure of the heavy chain of human factor XIIa.
J.BIOL.CHEM. 260 5328-5341 (1985).
 
2. PATTHY, L., TREXLER, M., VALI, V., BANYAI, L. AND VARADI, A.
Kringles: Modules specialized for protein binding.
FEBS LETT. 171 131-136 (1984).
 
3. ATKINSON, R.A. AND WILLIAMS, R.J.P.
Solution structure of the kringle 4 domain from human plasminogen by
1H nuclear magnetic resonance spectroscopy and distance geometry.
J.MOL.BIOL. 212 541-552 (1990).

Documentation
Kringles are autonomous structural domains, found throughout the blood 
clotting and fibrinolytic proteins. They are believed to play a role in
binding mediators (e.g., membranes, other proteins or phospholipids), and
in the regulation of proteolytic activity [1-3]. The kringle domain is 
characterised by a triple loop, 3-disulphide bridge structure, whose 
conformation is defined by a number of hydrogen bonds and small pieces of 
anti-parallel beta-sheet.
 
KRINGLE is a 4-element fingerprint that provides a signature for the 
kringle domain. The fingerprint was derived from an initial alignment of 
7 sequences (after McMullen [1]): the motifs span the full domain length,
motif 3 including the conserved hexapeptide encoded by PROSITE pattern
KRINGLE (PS00021). Four iterations on OWL11.0 were required to reach
convergence, at which point a true set comprising 34 sequences was
identified. One further sequence was of note: UROK_CHICK is not identified
unambiguously by the fingerprint - although it matches strongly with motifs
1 and 3, it fails to match motifs 2 and 4.
 
An update on SPTR37_9f identified a true set of 53 sequences, and 10
partial matches.
Summary Information
  53 codes involving  4 elements
7 codes involving 3 elements
3 codes involving 2 elements
Composite Feature Index
453535353
37770
21221
1234
True Positives
APOA_HUMAN    FA12_HUMAN    HGFA_HUMAN    HGFL_HUMAN    
HGFL_MOUSE HGF_HUMAN HGF_MOUSE HGF_RAT
O02001 O18783 O35727 O55027
P70006 P70521 PLMN_BOVIN PLMN_ERIEU
PLMN_HUMAN PLMN_MACMU PLMN_MOUSE PLMN_PIG
Q01973 Q01974 Q02935 Q07153
Q13208 Q13350 Q13494 Q14519
Q14520 Q14870 Q15146 Q16609
Q17576 Q24488 Q25101 Q64007
Q90504 Q90865 Q90978 Q91001
Q91691 THRB_BOVIN THRB_HUMAN THRB_MOUSE
THRB_RAT UROT_BOVIN UROT_HUMAN UROT_MOUSE
UROT_RAT URT1_DESRO URT2_DESRO URTB_DESRO
URTG_DESRO
True Positive Partials
Codes involving 3 elements
Q16618 UROK_BOVIN UROK_HUMAN UROK_MOUSE
UROK_PAPCY UROK_PIG UROK_RAT
Codes involving 2 elements
Q17591 Q98063 UROK_CHICK
Sequence Titles
APOA_HUMAN  APOLIPOPROTEIN(A) PRECURSOR (EC 3.4.21.-) (APO(A)) (LP(A)) - HOMO SAPIENS (HUMAN). 
FA12_HUMAN COAGULATION FACTOR XII PRECURSOR (EC 3.4.21.38) (HAGEMAN FACTOR) (HAF) - HOMO SAPIENS (HUMAN).
HGFA_HUMAN HEPATOCYTE GROWTH FACTOR ACTIVATOR PRECURSOR (EC 3.4.21.-) (HGF ACTIVATOR) - HOMO SAPIENS (HUMAN).
HGFL_HUMAN HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN PRECURSOR (MACROPHAGE STIMULATORY PROTEIN) (MSP) (MACROPHAGE STIMULATING PROTEIN) - HOMO SAPIENS (HUMAN).
HGFL_MOUSE HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN PRECURSOR (MACROPHAGE STIMULATORY PROTEIN) (MSP) - MUS MUSCULUS (MOUSE).
HGF_HUMAN HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A) - HOMO SAPIENS (HUMAN).
HGF_MOUSE HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A) - MUS MUSCULUS (MOUSE).
HGF_RAT HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A) - RATTUS NORVEGICUS (RAT).
O02001 NEUROSPECIFIC RECEPTOR TYROSINE KINASE - DROSOPHILA MELANOGASTER (FRUIT FLY).
O18783 PLASMINOGEN - MACROPUS EUGENII (TAMMAR WALLABY).
O35727 FACTOR XII - MUS MUSCULUS (MOUSE).
O55027 HEPATOCYTE GROWTH FACTOR (HEPATOCYTE GROWTH FACTOR NK1) - MUS MUSCULUS (MOUSE).
P70006 HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN PRECURSOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P70521 HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN PRECURSOR (MACROPHAGE STIMULATORY PROTEIN) (MSP) - RATTUS NORVEGICUS (RAT).
PLMN_BOVIN PLASMINOGEN PRECURSOR (EC 3.4.21.7) - BOS TAURUS (BOVINE).
PLMN_ERIEU PLASMINOGEN PRECURSOR (EC 3.4.21.7) - ERINACEUS EUROPAEUS (WESTERN EUROPEAN HEDGEHOG).
PLMN_HUMAN PLASMINOGEN PRECURSOR (EC 3.4.21.7) [CONTAINS: ANGIOSTATIN] - HOMO SAPIENS (HUMAN).
PLMN_MACMU PLASMINOGEN PRECURSOR (EC 3.4.21.7) - MACACA MULATTA (RHESUS MACAQUE).
PLMN_MOUSE PLASMINOGEN PRECURSOR (EC 3.4.21.7) [CONTAINS: ANGIOSTATIN] - MUS MUSCULUS (MOUSE).
PLMN_PIG PLASMINOGEN (EC 3.4.21.7) - SUS SCROFA (PIG).
Q01973 PROTEIN-TYROSINE KINASE TRANSMEMBRANE RECEPTOR ROR1 PRECURSOR (EC 2.7.1.112) - HOMO SAPIENS (HUMAN).
Q01974 PROTEIN-TYROSINE KINASE TRANSMEMBRANE RECEPTOR ROR2 PRECURSOR (EC 2.7.1.112) - HOMO SAPIENS (HUMAN).
Q02935 HEPATOCYTE GROWTH FACTOR, HEAVY CHAIN PRECURSOR - HOMO SAPIENS (HUMAN).
Q07153 TYROSINE KINASE RECEPTOR PRECURSOR (EC 2.7.1.112) (TRK-RELATED RECEPTOR) - TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY).
Q13208 HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN HOMOLOG (D1F15S1A) - HOMO SAPIENS (HUMAN).
Q13350 HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN PRECURSOR (MACROPHAGE STIMULATORY PROTEIN) (MSP) (MACROPHAGE STIMULATING PROTEIN) - HOMO SAPIENS (HUMAN).
Q13494 HGF AGONIST/ANTAGONIST - HOMO SAPIENS (HUMAN).
Q14519 COMPETITIVE HGF ANTAGONIST - HOMO SAPIENS (HUMAN).
Q14520 HGF ACTIVATOR LIKE PROTEIN - HOMO SAPIENS (HUMAN).
Q14870 MACROPHAGE-STIMULATING PROTEIN PRECURSOR - HOMO SAPIENS (HUMAN).
Q15146 PLASMINOGEN PRECURSOR - HOMO SAPIENS (HUMAN).
Q16609 (APOARGC) - HOMO SAPIENS (HUMAN).
Q17576 KIN-8 PROTEIN - CAENORHABDITIS ELEGANS.
Q24488 NEUROTROPHIC RECEPTOR PRECURSOR (PROTEIN TYROSINE KINASE) (EC 2.7.1.112) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q25101 SERINE PROTEINASE - HERDMANIA MOMUS.
Q64007 HEPATOCYTE GROWTH FACTOR - MUS MUSCULUS (MOUSE).
Q90504 THROMBIN - EPTATRETUS STOUTII (PACIFIC HAGFISH).
Q90865 HEPATOCYTE GROWTH FACTOR-LIKE/MACROPHAGE STIMULATING PROTEIN - GALLUS GALLUS (CHICKEN).
Q90978 HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A) (HGF/SF) - GALLUS GALLUS (CHICKEN).
Q91001 THROMBIN - GALLUS GALLUS (CHICKEN).
Q91691 GROWTH FACTOR LIVERTINE - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
THRB_BOVIN PROTHROMBIN PRECURSOR (EC 3.4.21.5) - BOS TAURUS (BOVINE).
THRB_HUMAN PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II) - HOMO SAPIENS (HUMA
THRB_MOUSE PROTHROMBIN PRECURSOR (EC 3.4.21.5) - MUS MUSCULUS (MOUSE).
THRB_RAT PROTHROMBIN PRECURSOR (EC 3.4.21.5) - RATTUS NORVEGICUS (RAT).
UROT_BOVIN TISSUE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T-PLASMINOGEN ACTIVATOR) - BOS TAURUS (BOVINE).
UROT_HUMAN TISSUE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T-PLASMINOGEN ACTIVATOR) (ALTEPLASE) (RETEPLASE) - HOMO SAPIENS (HUMAN).
UROT_MOUSE TISSUE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T-PLASMINOGEN ACTIVATOR) - MUS MUSCULUS (MOUSE).
UROT_RAT TISSUE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T-PLASMINOGEN ACTIVATOR) - RATTUS NORVEGICUS (RAT).
URT1_DESRO SALIVARY PLASMINOGEN ACTIVATOR ALPHA 1 PRECURSOR (EC 3.4.21.68) (DSPA ALPHA-1) - DESMODUS ROTUNDUS (VAMPIRE BAT).
URT2_DESRO SALIVARY PLASMINOGEN ACTIVATOR ALPHA 2 PRECURSOR (EC 3.4.21.68) (DSPA ALPHA-2) (BAT-PA) (T-PLASMINOGEN ACTIVATOR) - DESMODUS ROTUNDUS (VAMPIRE BAT).
URTB_DESRO SALIVARY PLASMINOGEN ACTIVATOR BETA PRECURSOR (EC 3.4.21.68) (DSPA BETA) - DESMODUS ROTUNDUS (VAMPIRE BAT).
URTG_DESRO SALIVARY PLASMINOGEN ACTIVATOR GAMMA PRECURSOR (EC 3.4.21.68) (DSPA GAMMA) - DESMODUS ROTUNDUS (VAMPIRE BAT).

Q16618 UROKINASE PRECURSOR (EC 3.4.99.26) - HOMO SAPIENS (HUMAN).
UROK_BOVIN UROKINASE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.73) (UPA) (U-PLASMINOGEN ACTIVATOR) - BOS TAURUS (BOVINE).
UROK_HUMAN UROKINASE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.73) (UPA) (U-PLASMINOGEN ACTIVATOR) - HOMO SAPIENS (HUMAN).
UROK_MOUSE UROKINASE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.73) (UPA) (U-PLASMINOGEN ACTIVATOR) - MUS MUSCULUS (MOUSE).
UROK_PAPCY UROKINASE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.73) (UPA) (U-PLASMINOGEN ACTIVATOR) - PAPIO CYNOCEPHALUS (YELLOW BABOON).
UROK_PIG UROKINASE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.73) (UPA) (U-PLASMINOGEN ACTIVATOR) - SUS SCROFA (PIG).
UROK_RAT UROKINASE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.73) (UPA) (U-PLASMINOGEN ACTIVATOR) - RATTUS NORVEGICUS (RAT).

Q17591 C02B4.1 PROTEIN - Caenorhabditis elegans.
Q98063 NEURAMINIDASE - INFLUENZA A VIRUS.
UROK_CHICK UROKINASE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.73) (UPA) (U-PLASMINOGEN ACTIVATOR) - GALLUS GALLUS (CHICKEN).
Scan History
OWL11_0    4  500  NSINGLE    
OWL17_1 1 250 NSINGLE
OWL18_0 1 150 NSINGLE
OWL19_1 1 150 NSINGLE
OWL26_0 1 250 NSINGLE
SPTR37_9f 3 350 NSINGLE
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
CYEDQGISYRGTWSTA UKHUT 127 127 -
CYHGDGQSYRGTSSTT PLMN_MACMU 377 377 -
CYHGDGQSYRGTSSTT PLMN_HUMAN 377 377 -
CYEDQGISYRGTWSTA HUMPAR 127 127 -
CYEDQGISYRGTWSTA HUMTPAR 81 81 -
CYEGNGHFYRGKASTD EZEC572 50 50 -
CYDGRGLSYRGLARTT !F12HA 198 198 -

Motif 2 width=13
Element Seqn Id St Int Rpt
ESGAECTNWNSSA HUMTPAR 97 0 -
TTGKKCQSWSSMT PLMN_MACMU 393 0 -
TTGKKCQSWSSMT PLMN_HUMAN 393 0 -
TMGRPCLPWNSAT EZEC572 66 0 -
LSGAPCQPWASEA !F12HA 214 0 -
ESGAECTNWNSSA UKHUT 143 0 -
ESGAECTNWNSSA HUMPAR 143 0 -

Motif 3 width=21
Element Seqn Id St Int Rpt
GLGGHAFCRNPDNDIRPWCFV !F12HA 240 13 -
GLGNHNYCRNPDRDSKPWCYV UKHUT 172 16 -
GLGNHNYCRNPDRDSKPWCYV HUMPAR 172 16 -
GLGNHNYCRNPDRDSKPWCYV HUMTPAR 126 16 -
GLGKHNYCRNPDNRRRPWCYV EZEC572 95 16 -
AGLTMNYCRNPDADKGPWCFT PLMN_HUMAN 419 13 -
AGLTMNYCRNPDADKGPWCFT PLMN_MACMU 419 13 -

Motif 4 width=12
Element Seqn Id St Int Rpt
KYSSEFCSTPAC HUMTPAR 151 4 -
KYSSEFCSTPAC HUMPAR 197 4 -
KYSSEFCSTPAC UKHUT 197 4 -
SVRWEYCNLKKC PLMN_HUMAN 443 3 -
SVRWEYCNLKKC PLMN_MACMU 443 3 -
RLSWEYCDLAQC !F12HA 265 4 -
KPLVQECMVHDC EZEC572 120 4 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
CYHGNGQSYRGTYSTT APOA_HUMAN 142 142 -
CYHSNGQSYRGTYFTT Q16609 28 28 -
CYHGNGQSYRGTSSTT PLMN_BOVIN 384 384 -
CYHGDGQSYRGTSSTT PLMN_HUMAN 377 377 -
CYHGDGQSYRGTSSTT PLMN_MACMU 377 377 -
CYHGDGQSYRGTSSTT Q15146 377 377 -
CYRGNGESYRGTSSTT PLMN_PIG 358 358 -
CLKGRGENYRGTVSVT PLMN_MOUSE 275 275 -
CYEGKGENYRGTTSTT O18783 371 371 -
CYQGNGQTYRGTSSTT PLMN_ERIEU 379 379 -
CIIGKGRSYKGTVSIT HGF_HUMAN 128 128 -
CIIGKGRSYKGTVSIT Q02935 128 128 -
CMTCNGESYRGPMDHT HGF_MOUSE 212 212 -
CMTCNGESYRGPMDHT Q64007 212 212 -
CIMDNGVSYRGTVART HGFL_MOUSE 110 110 -
CMTCNGESYRGPMDHT HGF_RAT 212 212 -
CVWCNGEDYRGEVDVT P70521 191 191 -
CIMNNGVGYRGTMATT Q14870 110 110 -
CIMNNGVGYRGTMATT Q13350 110 110 -
CIMNNGVGYRGTMATT HGFL_HUMAN 110 110 -
CIIGKGRSYKGTVSIT Q14519 128 128 -
CLTCNGEDYRGSVDRT Q91691 199 199 -
CVVGNGNTYRGTVSKT P70006 119 119 -
CYFGNGSAYRGTHSLT UROT_HUMAN 215 215 -
CMTCNGESYRGPMDHT Q90978 207 207 -
CVWCNGEEYRGAVDRT Q13208 166 166 -
CYTGNGLAYRGTRSHT UROT_BOVIN 219 219 -
CIIGKGRSYKGTVSIT Q13494 128 128 -
CIVANGTSYRGTRDTT Q90865 108 108 -
CIIGKGGSYKGTVSIT O55027 129 129 -
CYDGRGLSYRGLARTT FA12_HUMAN 217 217 -
CYVGKGVTYRGTHSFT UROT_RAT 213 213 -
CFLGNGTGYRGVASTS HGFA_HUMAN 286 286 -
CYVGKGVTYRGTHSLT UROT_MOUSE 213 213 -
CYNGSGMDYRGTASTT Q01974 316 316 -
CAEGVGMNYRGNVSVT THRB_BOVIN 109 109 -
CYEGRGLSYRGQAGTT O35727 217 217 -
CYVGDGYSYRGKMNRT Q14520 194 194 -
CYNNNGRFYQGSVNVT Q07153 464 464 -
CYKDQGVTYRGTWSTS URTG_DESRO 45 45 -
CYKDQGVTYRGTWSTS URT2_DESRO 128 128 -
CYKDQGVTYRGTWSTS URTB_DESRO 82 82 -
CAMDLGLNYHGNVSVT THRB_RAT 109 109 -
CAMDLGVNYLGTVNVT THRB_MOUSE 109 109 -
CAEGLGTNYRGHVNIT THRB_HUMAN 108 108 -
FDIENPESYQGAISRT Q25101 24 24 -
CESEKGMLYTGTLSVT Q91001 207 207 -
CYEGQGVTYRGTWSTA URT1_DESRO 128 128 -
CYNSTGVDYRGTVSVT Q01973 313 313 -
CRNGNGRFYMGTMNVS O02001 203 203 -
CYVNSGTQYEGTVAQT Q17576 232 232 -
CVRREGRDYRGDLNIT Q90504 17 17 -
CYWEDGSTYRGVANVS Q24488 237 237 -

Motif 2 width=13
Element Seqn Id St Int Rpt
VTGRTCQAWSSMT APOA_HUMAN 158 0 -
VTGRTCQAWSSMT Q16609 44 0 -
ITGRKCQSWSSMT PLMN_BOVIN 400 0 -
TTGKKCQSWSSMT PLMN_HUMAN 393 0 -
TTGKKCQSWSSMT PLMN_MACMU 393 0 -
TTGKKCQSWSSMT Q15146 393 0 -
ITGRKCQSWVSMT PLMN_PIG 374 0 -
VSGKTCQRWSEQT PLMN_MOUSE 291 0 -
ISGKKCQAWSSMT O18783 387 0 -
ITGKKCQPWTSMR PLMN_ERIEU 395 0 -
KSGIKCQPWSSMI HGF_HUMAN 144 0 -
KSGIKCQPWSSMI Q02935 144 0 -
ESGKTCQRWDQQT HGF_MOUSE 228 0 -
ESGKTCQRWDQQT Q64007 228 0 -
ESGRECQRWDLQH HGFL_MOUSE 207 81 -
ESGKTCQRWDQQT HGF_RAT 228 0 -
ESGRECQRWDLQH P70521 207 0 -
ESGRECQRWDLQH Q14870 207 81 -
ESGRECQRWDLQH Q13350 207 81 -
ESGRECQRWDLQH HGFL_HUMAN 207 81 -
KSGIKCQPWSSMI Q14519 144 0 -
ESGKECQRWDLQT Q91691 215 0 -
ESGKECQRWDLQA P70006 216 81 -
ESGASCLPWNSMI UROT_HUMAN 231 0 -
ESGKECQRWDLQR Q90978 223 0 -
ESGRECQRWDLQH Q13208 182 0 -
KSGASCLPWNSVF UROT_BOVIN 235 0 -
KSGIKCQPWSSMI Q13494 144 0 -
ESGTECQRWDLQH Q90865 205 81 -
KSGIKCQPWNSMI O55027 145 0 -
LSGAPCQPWASEA FA12_HUMAN 233 0 -
TSKASCLPWNSMI UROT_RAT 229 0 -
ASGLSCLAWNSDL HGFA_HUMAN 302 0 -
TSQASCLPWNSIV UROT_MOUSE 229 0 -
KSGHQCQPWALQH Q01974 332 0 -
RSGIECQLWRSRY THRB_BOVIN 125 0 -
QSGAPCQRWTVEA O35727 233 0 -
VNQHACLYWNSHL Q14520 210 0 -
ASGISCQRWSEQA Q07153 480 0 -
ESGAQCINWNSNL URTG_DESRO 61 0 -
ESGAQCINWNSNL URT2_DESRO 144 0 -
ESGAQCINWNSNL URTB_DESRO 98 0 -
HTGIECQLWRSRY THRB_RAT 125 0 -
HTGIQCQLWRSRY THRB_MOUSE 125 0 -
RSGIECQLWRSRY THRB_HUMAN 124 0 -
LGGETCQSWDLQT Q25101 40 0 -
VSGARCLPWASEK Q91001 223 0 -
ESRVECINWNSSL URT1_DESRO 144 0 -
KSGRQCQPWNSQY Q01973 329 0 -
KSGIPCQRWDTQY O02001 219 0 -
SSGKQCAPWIDST Q17576 248 0 -
WTGKPCLPWRGSY Q90504 33 0 -
ASGKPCLRWSWLM Q24488 253 0 -

Motif 3 width=21
Element Seqn Id St Int Rpt
AGLIMNYCRNPDAVAAPYCYT APOA_HUMAN 184 13 -
DGLISNYCRNPDCSAGPWCYT Q16609 70 13 -
AGLTMNYCRNPDADKSPWCYT PLMN_BOVIN 426 13 -
AGLTMNYCRNPDADKGPWCFT PLMN_HUMAN 419 13 -
AGLTMNYCRNPDADKGPWCFT PLMN_MACMU 419 13 -
AGLTMNYCRNPDADKGPWCFT Q15146 419 13 -
AGLTMNYCRNPDADKSPWCYT PLMN_PIG 400 13 -
AGLEMNYCRNPDGDKGPWCYT PLMN_MOUSE 419 115 -
ADLIRNYCRNPDGDKSPWCYT O18783 413 13 -
ADLTMNYCRNPDGDKGPWCYT PLMN_ERIEU 421 13 -
KGFDDNYCRNPDGQPRPWCYT HGF_HUMAN 253 96 -
KGFDDNYCRNPDGQPRPWCYT Q02935 253 96 -
KGFDDNYCRNPDGKPRPWCYT HGF_MOUSE 254 13 -
KGFDDNYCRNPDGKPRPWCYT Q64007 254 13 -
KDLKDNYCRNPDGSERPWCYT HGFL_MOUSE 233 13 -
KGFDDNYCRNPDGKPRPWCYT HGF_RAT 254 13 -
KALKDNYCRNPDASERPWCYT P70521 233 13 -
QGLDDNYCRNPDGSERPWCYT Q14870 233 13 -
QGLDDNYCRNPDGSERPWCYT Q13350 233 13 -
QGLDDNYCRNPDGSERPWCYT HGFL_HUMAN 233 13 -
KGFDDNYCRNPDGQPRPWCYT Q14519 253 96 -
KSLDDNYCRNPDSSERPWCYT Q91691 241 13 -
KSLDDNYCRNPDSSERPWCYT P70006 242 13 -
GLGKHNYCRNPDGDAKPWCHV UROT_HUMAN 260 16 -
KGFDDNYCRNPDGKLRPWCYT Q90978 249 13 -
QGLDDNYCRSPDGSQRPWCYT Q13208 208 13 -
GLGKHNHCRNPDGDAQPWCHV UROT_BOVIN 264 16 -
KDLQENYCRNPRGEEGGPWCF Q13494 170 13 -
KGLDDNYCRNPDSSEQPWCYT Q90865 231 13 -
KDLQENYCRNPRGEEGGPWCF O55027 171 13 -
GLGGHAFCRNPDNDIRPWCFV FA12_HUMAN 259 13 -
GLGRHNYCRNPDGDAKPWCHV UROT_RAT 258 16 -
GLGPHAYCRNPDNDERPWCYV HGFA_HUMAN 331 16 -
GLARHNYCRNPDGDARPWCHV UROT_MOUSE 258 16 -
LGGGHAYCRNPGGQMEGPWCF Q01974 358 13 -
ADLRENFCRNPDGSITGPWCY THRB_BOVIN 151 13 -
GLGHHAFCRNPDNDTRPWCFV O35727 259 13 -
GIGEHNFCRNPDADEKPWCFI Q14520 239 16 -
LANSDNFCRNPGGESERPWCY Q07153 506 13 -
GLGNHNYCRNPDGASKPWCYV URTG_DESRO 90 16 -
GLGNHNYCRNPDNNSKPWCYV URT2_DESRO 173 16 -
GLGNHNYCRNPDNNSKPWCYV URTB_DESRO 127 16 -
ADLKENFCRNPDSSTSGPWCY THRB_RAT 151 13 -
ADLKENFCRNPDSSTTGPWCY THRB_MOUSE 151 13 -
ADLQENFCRNPDSSTTGPWCY THRB_HUMAN 150 13 -
GLAGNNYCRNPDQDWRGPWCY Q25101 67 14 -
VKLLENYCRNPDADDEGVWCV Q91001 249 13 -
GLGNHNYCRNPNGAPKPWCYV URT1_DESRO 173 16 -
LNGGHSYCRNPGNQKEAPWCF Q01973 355 13 -
LLEGENYCRNAGGEEPHPWCY O02001 245 13 -
LMNSKNYCRNPGGKKSRPWCY Q17576 272 11 -
AGLTSNYCRNPDGDSEGVWCY Q90504 56 10 -
ELIGQNYCRNPGSVENSPWCF Q24488 273 7 -

Motif 4 width=12
Element Seqn Id St Int Rpt
GVRWEYCNLTQC APOA_HUMAN 1348 1143 -
NVRWEYCNLTRC Q16609 94 3 -
RVRWEFCNLKKC PLMN_BOVIN 450 3 -
SVRWEYCNLKKC PLMN_HUMAN 443 3 -
SVRWEYCNLKKC PLMN_MACMU 443 3 -
SVRWEYCNLKKC Q15146 443 3 -
RVRWEYCNLKKC PLMN_PIG 424 3 -
SVRWEYCNLKRC PLMN_MOUSE 443 3 -
TVRWEFCNLEKC O18783 437 3 -
SVRWEFCNLKKC PLMN_ERIEU 445 3 -
HTRWEYCAIKTC HGF_HUMAN 277 3 -
HTRWEYCAIKTC Q02935 277 3 -
DTPWEYCAIKTC HGF_MOUSE 278 3 -
DTPWEYCAIKTC Q64007 278 3 -
NVEREFCDLPSC HGFL_MOUSE 257 3 -
DTPWEYCAIKMC HGF_RAT 278 3 -
NVEREFCDLPSC P70521 257 3 -
QIEREFCDLPRC Q14870 257 3 -
QIEREFCDLPRC Q13350 257 3 -
QIEREFCDLPRC HGFL_HUMAN 257 3 -
HTRWEYCAIKNM Q14519 277 3 -
NVEKEFCRITKC Q91691 265 3 -
NVEREFCHITKC P70006 266 3 -
RLTWEYCDVPSC UROT_HUMAN 285 4 -
NTPWEFCAIKTC Q90978 273 3 -
QIEREFCDLPRC Q13208 232 3 -
QLTWEYCDVPQC UROT_BOVIN 289 4 -
EVRYEVCDIPQC Q13494 195 4 -
ALEREFCRIRVC Q90865 255 3 -
EVRYEVCDIPQC O55027 196 4 -
RLSWEYCDLAQC FA12_HUMAN 284 4 -
KLTWEYCDMSPC UROT_RAT 283 4 -
ALSWEYCRLEAC HGFA_HUMAN 356 4 -
KLTWEYCDMSPC UROT_MOUSE 283 4 -
NVRMELCDVPSC Q01974 383 4 -
PGDFEYCDLNYC THRB_BOVIN 281 109 -
RLSWDYCGLEQC O35727 284 4 -
KVKWEYCDVSAC Q14520 265 5 -
DIRWEFCNVPQC Q07153 531 4 -
KFTSESCSVPVC URTG_DESRO 115 4 -
KFILEFCSVPVC URT2_DESRO 198 4 -
KFILEFCSVPVC URTB_DESRO 152 4 -
TVRREECSIPVC THRB_RAT 176 4 -
TVRREECSVPVC THRB_MOUSE 176 4 -
TVRRQECSIPVC THRB_HUMAN 175 4 -
FMRWDYCDIPIC Q25101 92 4 -
PPYFEYCDLHYC Q91001 273 3 -
KFTSESCSVPVC URT1_DESRO 198 4 -
NFKSDLCDIPAC Q01973 380 4 -
SVRWQHCDIPMC O02001 270 4 -
MGQEEYCDVPQC Q17576 296 3 -
GTDVDYCQLNYC Q90504 82 5 -
ERIIELCDIPKC Q24488 299 5 -