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PR00010

Identifier
EGFBLOOD  [View Relations]  [View Alignment]  
Accession
PR00010
No. of Motifs
4
Creation Date
13-SEP-1991  (UPDATE 24-JUN-1999)
Title
Type II EGF-like signature
Database References

PROSITE; PS00022 EGF
BLOCKS; BL00022
PFAM; PF00008 EGF
INTERPRO; IPR001438
PDB; 1IXA
SCOP; 1IXA
Literature References
1. CAMPBELL, I.D., BARON, M., COOKE, R.M., DUDGEON, T.J., FALLON, A.,
HARVEY, T.S. AND TAPPIN, M.J.
Structure-function relationships in Epidermal Growth Factor (EGF) and 
Transforming Growth Factor-alpha (TGF-alpha).
BIOCHEM.PHARMACOL. 40(1) 35-40 (1990).
 
2. REES, D.J.G., JONES, I.M., HANDFORD, P.A., WALTER, S.J., ESNOUF, M.P.,
SMITH, K.J. AND BROWNLEE, G.G.
The role of beta-hydroxyaspartate and adjacent carboxylate residues in
the first EGF domain of human factor IX.
EMBO J. 7(7) 2053-2061 (1988).
 
3. GREENWALD, I.
Lin-12, a nematode homeotic, is homologous to a set of mammalian proteins
that includes Epidermal Growth Factor. 
CELL 43 583-590 (1985).
 
4. WHARTON, K.A., JOHANSEN, K.M., XU, T. AND ARTAVANIS-TSKAKONAS S.
Nucleotide sequence from the neurogenic locus notch implies a gene product
that shares homology with proteins containing EGF-like repeats.
CELL 43 567-581 (1985).

Documentation
EGF-like repeats occur in coagulation factors, notch and xotch proteins, 
protein Z, urokinases, plasminogen factors and the lin-12 protein [1-4]: 
the repeat pattern is EGF-like in the sense that it does not share the 
exact Cys spacings of the type I EGF motif (see EGFTGF). The primary 
structures of many of the superfamily members contain regions that are 
dominated by multiple EGF-like repeats: these have been linked to some 
physiological role, though the precise nature of this role is as yet
unclear.
 
EGFBLOOD is a 4-element fingerprint that provides a signature for type II
EGF-like repeats. The fingerprint was derived from an initial alignment 
of 7 sequences [1]: the 4 motifs include 6 cysteines believed to be involved
in disulphide bond formation, motifs 3 and 4 spanning the region encoded by
PROSITE pattern EGF (PS00022). Three iterations on OWL12.0 were required
to reach convergence, at which point a true set comprising 37 sequences was
identified. Several partial matches were also found: 15 sequences matched
just 3 motifs, and 17 matched only 2. In view of the poor definition
between the true set, subfamilies and noise, this is not a powerful
fingerprint, but is included to illustrate that a distinction can be drawn
between EGF and EGF-like repeats.
 
An update on SPTR37_9f identified a true set of 58 sequences, and 94
partial matches.
Summary Information
  58 codes involving  4 elements
39 codes involving 3 elements
55 codes involving 2 elements
Composite Feature Index
458585858
337252728
237351622
1234
True Positives
CRB_DROME     DLL1_HUMAN    DLL1_MOUSE    DLL1_RAT      
FA10_CHICK FA7_BOVIN FA9_BOVIN FA9_HUMAN
FBN1_BOVIN FBN1_HUMAN FBN2_HUMAN FBN2_MOUSE
FBP1_STRPU FBP3_STRPU LRP1_CHICK MFGM_MOUSE
MFGM_RAT NOTC_BRARE NOTC_DROME NOTC_XENLA
NTC1_MOUSE NTC1_RAT NTC3_MOUSE NTC4_MOUSE
O00306 O14902 O15122 O16004
O35442 O35516 O35675 O57409
O57462 O61240 O77609 O77610
O77611 O77612 O88279 O88516
O88564 P78504 P79941 P87357
P91526 PGBM_HUMAN PGBM_MOUSE PGCV_HUMAN
PGCV_MOUSE Q15816 Q19350 Q25253
Q61291 Q63722 Q90656 Q91902
Q99940 SERR_DROME
True Positive Partials
Codes involving 3 elements
AGRI_RAT DLK_MOUSE DL_DROME FA10_BOVIN
FA10_HUMAN FA7_HUMAN FA7_MOUSE FA7_RABIT
FA9_CANFA FBN1_MOUSE GLP1_CAEEL HGFA_HUMAN
LI12_CAEEL LRP1_HUMAN MFGM_PIG O54740
O61230 O70534 O88277 O88278
O88280 O88281 O88671 O88840
O88947 P79787 PGCA_CHICK PGCV_CHICK
PRTZ_HUMAN Q14339 Q15213 Q17494
Q26627 Q61204 Q61810 Q62779
Q63207 Q99108 SLIT_DROME
Codes involving 2 elements
AGRI_CHICK CO6_HUMAN CRIO_MOUSE DLK_HUMAN
ECM_HUMAN FA10_RABIT FATH_HUMAN FAT_DROME
FBLA_HUMAN FBLB_HUMAN FBLC_HUMAN FBLC_MOUSE
FBLD_HUMAN FBLD_MOUSE GSHC_ARATH LRP2_HUMAN
MFGM_HUMAN NID2_HUMAN O08999 O15943
O35474 O35475 O35806 O43854
O46370 O60494 O61537 O62070
O70244 O88349 P97766 PGCA_BOVIN
PGCB_BOVIN PGCN_MOUSE PGCN_RAT PRTZ_BOVIN
Q14393 Q14767 Q18291 Q20535
Q20852 Q20911 Q23587 Q25464
Q28019 Q61109 Q91649 Q92098
TGFB_HUMAN TGFB_RAT TIE1_BOVIN TIE1_HUMAN
TIE1_MOUSE UROT_BOVIN URT1_DESRO
Sequence Titles
CRB_DROME   CRUMBS PROTEIN PRECURSOR (95F) - DROSOPHILA MELANOGASTER (FRUIT FLY). 
DLL1_HUMAN DELTA-LIKE PROTEIN 1 PRECURSOR (DELTA1) - HOMO SAPIENS (HUMAN).
DLL1_MOUSE DELTA-LIKE PROTEIN 1 PRECURSOR (DELTA1) - MUS MUSCULUS (MOUSE).
DLL1_RAT DELTA-LIKE PROTEIN 1 PRECURSOR (DELTA1) - RATTUS NORVEGICUS (RAT).
FA10_CHICK COAGULATION FACTOR X PRECURSOR (EC 3.4.21.6) (STUART FACTOR) (VIRUS ACTIVATING PROTEASE) (VAP) - GALLUS GALLUS (CHICKEN).
FA7_BOVIN COAGULATION FACTOR VII (EC 3.4.21.21) - BOS TAURUS (BOVINE).
FA9_BOVIN COAGULATION FACTOR IX (EC 3.4.21.22) (CHRISTMAS FACTOR) - BOS TAURUS (BOVINE).
FA9_HUMAN COAGULATION FACTOR IX PRECURSOR (EC 3.4.21.22) (CHRISTMAS FACTOR) - HOMO SAPIENS (HUMAN).
FBN1_BOVIN FIBRILLIN 1 PRECURSOR (MP340) - BOS TAURUS (BOVINE).
FBN1_HUMAN FIBRILLIN 1 PRECURSOR - HOMO SAPIENS (HUMAN).
FBN2_HUMAN FIBRILLIN 2 PRECURSOR - HOMO SAPIENS (HUMAN).
FBN2_MOUSE FIBRILLIN 2 PRECURSOR - MUS MUSCULUS (MOUSE).
FBP1_STRPU FIBROPELLIN I PRECURSOR (EPIDERMAL GROWTH FACTOR-RELATED PROTEIN 1) (UEGF-1) - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
FBP3_STRPU FIBROPELLIN C PRECURSOR (EPIDERMAL GROWTH FACTOR-RELATED PROTEIN 3) (EGF III) (FIBROPELLIN III) - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
LRP1_CHICK LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1 PRECURSOR (LRP) (ALPHA-2-MACR
MFGM_MOUSE MILK FAT GLOBULE-EGF FACTOR 8 PRECURSOR (MFG-E8) (MFGM) (SPERM SURFACE PROTEIN SP47) (MP47) - MUS MUSCULUS (MOUSE).
MFGM_RAT MILK FAT GLOBULE-EGF FACTOR 8 PRECURSOR (MFG-E8) (O-ACETYL GD3 GANGLIOSIDE SYNTHASE) (AGS) (MFGM) - RATTUS NORVEGICUS (RAT).
NOTC_BRARE NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN PRECURSOR - Brachydanio rerio (Zebrafish) (Zebra danio).
NOTC_DROME NEUROGENIC LOCUS NOTCH PROTEIN PRECURSOR - Drosophila melanogaster (Fruit fly).
NOTC_XENLA NEUROGENIC LOCUS NOTCH PROTEIN HOMOLOG PRECURSOR (XOTCH PROTEIN) - Xenopus laevis (African clawed frog).
NTC1_MOUSE NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 PRECURSOR (MOTCH PROTEIN) - Mus musculus (Mouse).
NTC1_RAT NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 PRECURSOR - Rattus norvegicus (Rat).
NTC3_MOUSE NEUROGENIC LOCUS NOTCH 3 PROTEIN - Mus musculus (Mouse).
NTC4_MOUSE NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4 PRECURSOR (TRANSFORMING PROTEIN INT-3) - Mus musculus (Mouse).
O00306 NOTCH4 - Homo sapiens (Human).
O14902 TRANSMEMBRANE PROTEIN JAGGED 1 - HOMO SAPIENS (HUMAN).
O15122 JAGGED1 - HOMO SAPIENS (HUMAN).
O16004 NOTCH HOMOLOG - Lytechinus variegatus (Sea urchin).
O35442 NOTCH4 - Mus musculus (Mouse).
O35516 CELL SURFACE PROTEIN - Mus musculus (Mouse).
O35675 M-DELTA-LIKE 3 GENE PRECURSOR - MUS MUSCULUS (MOUSE).
O57409 DELTAB - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O57462 DELTAA - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O61240 HRNOTCH PROTEIN - Halocynthia roretzi (Sea squirt).
O77609 VERSICAN V0 SPLICE-VARIANT PRECURSOR - BOS TAURUS (BOVINE).
O77610 VERSICAN V1 SPLICE-VARIANT PRECURSOR - BOS TAURUS (BOVINE).
O77611 VERSICAN V2 SPLICE-VARIANT PRECURSOR - BOS TAURUS (BOVINE).
O77612 VERSICAN V3 SPLICE-VARIANT PRECURSOR - BOS TAURUS (BOVINE).
O88279 MEGF4 - RATTUS NORVEGICUS (RAT).
O88516 DELTA-LIKE 3 ALTERNATE SPLICE FORM 2 - MUS MUSCULUS (MOUSE).
O88564 VERSICAN V3 ISOFORM PRECURSOR - RATTUS NORVEGICUS (RAT).
P78504 JAGGED 1 (TRANSMEMBRANE PROTEIN JAGGED) - HOMO SAPIENS (HUMAN).
P79941 NOTCH LIGAND X-DELTA-2 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P87357 DELTAD TRANSMEMBRANE PROTEIN PRECURSOR - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
P91526 SIMILARITY TO MULTIPLE EGF-LIKE DOMAINS - CAENORHABDITIS ELEGANS.
PGBM_HUMAN BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN PRECURSOR (
PGBM_MOUSE BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN PRECURSOR (
PGCV_HUMAN VERSICAN CORE PROTEIN PRECURSOR (LARGE FIBROBLAST PROTEOGLYCAN) (CHONDROITIN SUL
PGCV_MOUSE VERSICAN CORE PROTEIN PRECURSOR (LARGE FIBROBLAST PROTEOGLYCAN) (CHONDROITIN SUL
Q15816 TRANSMEMBRANE PROTEIN JAGGED 1 - HOMO SAPIENS (HUMAN).
Q19350 SIMILAR TO EGF-LIKE REPEATS. NCBI GI: 1125776 - CAENORHABDITIS ELEGANS.
Q25253 NOTCH HOMOLOG SCALLOPED WINGS (SCL) - Lucilia cuprina (Greenbottle fly) (Australian sheep blowfly).
Q61291 LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN (AM2 RECEPTOR).
Q63722 JAGGED PROTEIN - RATTUS NORVEGICUS (RAT).
Q90656 TRANSMEMBRANE PROTEIN C-DELTA-1 - GALLUS GALLUS (CHICKEN).
Q91902 X-DELTA-1 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q99940 NOTCH4 - Homo sapiens (Human).
SERR_DROME SERRATE PROTEIN PRECURSOR (BEADED PROTEIN) - DROSOPHILA MELANOGASTER (FRUIT FLY).

AGRI_RAT AGRIN PRECURSOR - RATTUS NORVEGICUS (RAT).
DLK_MOUSE DELTA-LIKE PROTEIN PRECURSOR (DLK) (PREADIPOCYTE FACTOR 1) (PREF-1) (ADIPOCYTE DIFFERENTIATION INHIBITOR PROTEIN) [CONTAINS: FETAL ANTIGEN 1 (FA1)] - MUS MUSCULUS (MOUSE).
DL_DROME NEUROGENIC LOCUS DELTA PROTEIN PRECURSOR - DROSOPHILA MELANOGASTER (FRUIT FLY).
FA10_BOVIN COAGULATION FACTOR X PRECURSOR (EC 3.4.21.6) (STUART FACTOR) - BOS TAURUS (BOVINE).
FA10_HUMAN COAGULATION FACTOR X PRECURSOR (EC 3.4.21.6) (STUART FACTOR) - HOMO SAPIENS (HUMAN).
FA7_HUMAN COAGULATION FACTOR VII PRECURSOR (EC 3.4.21.21) (EPTACOG ALFA) - HOMO SAPIENS (HUMAN).
FA7_MOUSE COAGULATION FACTOR VII PRECURSOR (EC 3.4.21.21) - MUS MUSCULUS (MOUSE).
FA7_RABIT COAGULATION FACTOR VII PRECURSOR (EC 3.4.21.21) - ORYCTOLAGUS CUNICULUS (RABBIT).
FA9_CANFA COAGULATION FACTOR IX PRECURSOR (EC 3.4.21.22) (CHRISTMAS FACTOR) - CANIS FAMILIARIS (DOG).
FBN1_MOUSE FIBRILLIN 1 PRECURSOR - MUS MUSCULUS (MOUSE).
GLP1_CAEEL GLP-1 PROTEIN PRECURSOR - Caenorhabditis elegans.
HGFA_HUMAN HEPATOCYTE GROWTH FACTOR ACTIVATOR PRECURSOR (EC 3.4.21.-) (HGF ACTIVATOR) - HOMO SAPIENS (HUMAN).
LI12_CAEEL LIN-12 PROTEIN PRECURSOR - Caenorhabditis elegans.
LRP1_HUMAN LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1 PRECURSOR (LRP) (ALPHA-2-MACR
MFGM_PIG MILK FAT GLOBULE-EGF FACTOR 8 (MFG-E8) (MFGM) (SPERM SURFACE PROTEIN SP47) (PP47) - SUS SCROFA (PIG).
O54740 COAGULATION FACTOR X PRECURSOR (EC 3.4.21.6) - MUS MUSCULUS (MOUSE).
O61230 G-CADHERIN - Lytechinus variegatus (Sea urchin).
O70534 ZOG - RATTUS NORVEGICUS (RAT).
O88277 MEGF1 - Rattus norvegicus (Rat).
O88278 MEGF2 - Rattus norvegicus (Rat).
O88280 MEGF5 - RATTUS NORVEGICUS (RAT).
O88281 MEGF6 - RATTUS NORVEGICUS (RAT).
O88671 DELTA 3 - RATTUS NORVEGICUS (RAT).
O88840 MUTANT FIBRILLIN-1 - MUS MUSCULUS (MOUSE).
O88947 COAGULATION FACTOR X PRECURSOR - MUS MUSCULUS (MOUSE).
P79787 CHONDROITIN SULFATE PROTEOGLYCAN CORE PROTEIN - GALLUS GALLUS (CHICKEN).
PGCA_CHICK AGGRECAN CORE PROTEIN PRECURSOR (CARTILAGE-SPECIFIC PROTEOGLYCAN CORE PROTEIN) (
PGCV_CHICK VERSICAN CORE PROTEIN PRECURSOR (LARGE FIBROBLAST PROTEOGLYCAN) (CHONDROITIN SUL
PRTZ_HUMAN VITAMIN K-DEPENDENT PROTEIN Z PRECURSOR - HOMO SAPIENS (HUMAN).
Q14339 PREPROFACTOR VIIB PRECURSOR - HOMO SAPIENS (HUMAN).
Q15213 PROTEIN Z PRECURSOR - HOMO SAPIENS (HUMAN).
Q17494 B0393.5 PROTEIN - CAENORHABDITIS ELEGANS.
Q26627 SPERM RECEPTOR FOR EGG JELLY - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
Q61204 NOTCH2-LIKE (EGF REPEAT TRANSMEMBRANE PROTEIN) - MUS MUSCULUS (MOUSE).
Q61810 LATENT TRANSFORMING GROWTH FACTOR-BETA BINDING PROTEIN - MUS MUSCULUS (MOUSE).
Q62779 PREADIPOCYTE FACTOR 1 - RATTUS NORVEGICUS (RAT).
Q63207 FACTOR X - RATTUS NORVEGICUS (RAT).
Q99108 NEUROGENIC LOCUS DELTA PROTEIN PRECURSOR (VERSION 2) - DROSOPHILA MELANOGASTER (FRUIT FLY).
SLIT_DROME SLIT PROTEIN PRECURSOR - DROSOPHILA MELANOGASTER (FRUIT FLY).

AGRI_CHICK AGRIN PRECURSOR - GALLUS GALLUS (CHICKEN).
CO6_HUMAN Complement component C6 precursor - Homo sapiens (Human).
CRIO_MOUSE TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR) - MUS MUSCULUS (MOUSE).
DLK_HUMAN DELTA-LIKE PROTEIN PRECURSOR (DLK) [CONTAINS: FETAL ANTIGEN 1 (FA1)] - HOMO SAPIENS (HUMAN).
ECM_HUMAN ENDOTHELIAL CELL MULTIMERIN PRECURSOR - HOMO SAPIENS (HUMAN).
FA10_RABIT COAGULATION FACTOR X PRECURSOR (EC 3.4.21.6) (STUART FACTOR) - ORYCTOLAGUS CUNICULUS (RABBIT).
FATH_HUMAN CADHERIN-RELATED TUMOR SUPPRESSOR HOMOLOG PRECURSOR (FAT PROTEIN HOMOLOG) - HOMO SAPIENS (HUMAN).
FAT_DROME CADHERIN-RELATED TUMOR SUPPRESSOR PRECURSOR (FAT PROTEIN) - Drosophila melanogaster (Fruit fly).
FBLA_HUMAN FIBULIN-1, ISOFORM A PRECURSOR - HOMO SAPIENS (HUMAN).
FBLB_HUMAN FIBULIN-1, ISOFORM B PRECURSOR - HOMO SAPIENS (HUMAN).
FBLC_HUMAN FIBULIN-1, ISOFORM C PRECURSOR - HOMO SAPIENS (HUMAN).
FBLC_MOUSE FIBULIN-1, ISOFORM C PRECURSOR (BASEMENT-MEMBRANE PROTEIN 90) (BM-90) - MUS MUSCULUS (MOUSE).
FBLD_HUMAN FIBULIN-1, ISOFORM D PRECURSOR - HOMO SAPIENS (HUMAN).
FBLD_MOUSE FIBULIN-1, ISOFORM D PRECURSOR (BASEMENT-MEMBRANE PROTEIN 90) (BM-90) - MUS MUSCULUS (MOUSE).
GSHC_ARATH GLUTATHIONE REDUCTASE, CHLOROPLAST PRECURSOR (EC 1.6.4.2) (GR) (GRASE) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
LRP2_HUMAN LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 PRECURSOR (MEGALIN) (GLYCOPRO
MFGM_HUMAN MILK FAT GLOBULE-EGF FACTOR 8 PRECURSOR (MFG-E8) (HMFG) (BREAST EPITHELIAL ANTIGEN BA46) (MFGM) - HOMO SAPIENS (HUMAN).
NID2_HUMAN NIDOGEN-2 PRECURSOR (NID-2) (OSTEONIDOGEN) - HOMO SAPIENS (HUMAN).
O08999 LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 2 (LATENT TGF-BETA BINDING PROTEIN-2) - MUS MUSCULUS (MOUSE).
O15943 NEURAL-CADHERIN PRECURSOR (CADHERIN-N PROTEIN) (DN-CADHERIN) - Drosophila melanogaster (Fruit fly).
O35474 DEL1 MAJOR SPLICE VARIANT - MUS MUSCULUS (MOUSE).
O35475 DEL1 MINOR SPLICE VARIANT - MUS MUSCULUS (MOUSE).
O35806 LATENT TGF-BETA BINDING PROTEIN-2 LIKE PROTEIN - RATTUS NORVEGICUS (RAT).
O43854 INTEGRIN BINDING PROTEIN DEL-1 - HOMO SAPIENS (HUMAN).
O46370 PREADIPOCYTE FACTOR-1 - BOS TAURUS (BOVINE).
O60494 INTRINSIC FACTOR-B12 RECEPTOR PRECURSOR - HOMO SAPIENS (HUMAN).
O61537 SPERM TRANSMEMBRANE PROTEIN - CAENORHABDITIS ELEGANS.
O62070 C17D12.6 PROTEIN - CAENORHABDITIS ELEGANS.
O70244 INTRINSIC FACTOR-B12 RECEPTOR PRECURSOR - RATTUS NORVEGICUS (RAT).
O88349 LATENT TGF BETA BINDING PROTEIN - MUS MUSCULUS (MOUSE).
P97766 CRIPTO, FRL-1, CRYPTIC FAMILY 1 - MUS MUSCULUS (MOUSE).
PGCA_BOVIN AGGRECAN CORE PROTEIN PRECURSOR (CARTILAGE-SPECIFIC PROTEOGLYCAN CORE PROTEIN) (
PGCB_BOVIN BREVICAN CORE PROTEIN PRECURSOR - BOS TAURUS (BOVINE).
PGCN_MOUSE NEUROCAN CORE PROTEIN PRECURSOR - MUS MUSCULUS (MOUSE).
PGCN_RAT NEUROCAN CORE PROTEIN PRECURSOR (245 KD EARLY POSTNATAL CORE GLYCOPROTEIN) [CONT
PRTZ_BOVIN VITAMIN K-DEPENDENT PROTEIN Z - BOS TAURUS (BOVINE).
Q14393 GROWTH-ARREST-SPECIFIC PROTEIN - HOMO SAPIENS (HUMAN).
Q14767 LATENT TRANSFORMING GROWTH FACTOR-BETA-BINDING PROTEIN-2 (LTBP-2) - HOMO SAPIENS (HUMAN).
Q18291 C29A12.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q20535 SIMILARITY TO EGF-TYPE REPEATS - CAENORHABDITIS ELEGANS.
Q20852 COSMID F55G1 - CAENORHABDITIS ELEGANS.
Q20911 ZC116.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q23587 CODED FOR BY C. ELEGANS CDNA CEESR56 - CAENORHABDITIS ELEGANS.
Q25464 ADHESIVE PLAQUE MATRIX PROTEIN PRECURSOR - MYTILUS GALLOPROVINCIALIS.
Q28019 LATENT TGF-BETA BINDING PROTEIN-2 - BOS TAURUS (BOVINE).
Q61109 COAGULATION FACTOR VII - MUS MUSCULUS (MOUSE).
Q91649 FRL1 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q92098 PEMA-SRCR PROTEIN PRECURSOR - PETROMYZON MARINUS (SEA LAMPREY).
TGFB_HUMAN LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 1 PRECURSOR (TRANSFORMING GROWTH FACTOR BETA-1 BINDING PROTEIN 1) (TGF-BETA1-BP- 1) - HOMO SAPIENS (HUMAN).
TGFB_RAT LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 1 PRECURSOR (TRANSFORMING GROWTH FACTOR BETA-1 BINDING PROTEIN 1) (TGF-BETA1-BP- 1) (TRANSFORMING GROWTH FACTOR BETA-1 MASKING PROTEIN, LARGE SUBUNIT) - RATTUS NORVEGICUS (RAT).
TIE1_BOVIN TYROSINE-PROTEIN KINASE RECEPTOR TIE-1 PRECURSOR (EC 2.7.1.112) - BOS TAURUS (BOVINE).
TIE1_HUMAN TYROSINE-PROTEIN KINASE RECEPTOR TIE-1 PRECURSOR (EC 2.7.1.112) - HOMO SAPIENS (HUMAN).
TIE1_MOUSE TYROSINE-PROTEIN KINASE RECEPTOR TIE-1 PRECURSOR (EC 2.7.1.112) - MUS MUSCULUS (MOUSE).
UROT_BOVIN TISSUE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T-PLASMINOGEN ACTIVATOR) - BOS TAURUS (BOVINE).
URT1_DESRO SALIVARY PLASMINOGEN ACTIVATOR ALPHA 1 PRECURSOR (EC 3.4.21.68) (DSPA ALPHA-1) - DESMODUS ROTUNDUS (VAMPIRE BAT).
Scan History
OWL12_0    3  600  NSINGLE    
OWL17_1 1 700 NSINGLE
OWL18_0 1 700 NSINGLE
OWL19_1 1 700 NSINGLE
SPTR37_9f 5 700 NSINGLE
Initial Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
DIDECASAPCQN EGFH_STRPU 202 202 -
ASQACRTNPCLH FA12_HUMAN 174 174 -
PVKSCSEPRCFN UROT_HUMAN 82 82 -
DGDQCESNPCLN FA9_HUMAN 93 93 -
DGDQCASSPCQN FA7_HUMAN 106 106 -
DGDQCETSPCQN FA10_HUMAN 86 86 -
DIDECQSNPCLN NOTC_DROME 526 526 -

Motif 2 width=8
Element Seqn Id St Int Rpt
GGLCIDGI EGFH_STRPU 328 114 -
GGSCKDDI FA9_HUMAN 105 0 -
GGTCQQAL UROT_HUMAN 94 0 -
GGSCKDQL FA7_HUMAN 118 0 -
QGKCKDGL FA10_HUMAN 98 0 -
GGSCIDGI NOTC_DROME 1034 496 -
GGRCLEVE FA12_HUMAN 186 0 -

Motif 3 width=11
Element Seqn Id St Int Rpt
NSYECWCPFGF FA9_HUMAN 113 0 -
QSYICFCLPAF FA7_HUMAN 126 0 -
GEYTCTCLEGF FA10_HUMAN 106 0 -
NEYTCHCPSGF NOTC_DROME 1080 38 -
AGYTCQCRLGY EGFH_STRPU 336 0 -
GHRLCHCPVGY FA12_HUMAN 194 0 -
SDFVCQCPEGF UROT_HUMAN 104 2 -

Motif 4 width=7
Element Seqn Id St Int Rpt
EGRNCET FA7_HUMAN 137 0 -
EGKNCEL FA9_HUMAN 124 0 -
IGVNCEE EGFH_STRPU 347 0 -
TGPFCDV FA12_HUMAN 205 0 -
AGKCCEI UROT_HUMAN 115 0 -
YGKNCEL NOTC_DROME 1368 277 -
EGKNCEL FA10_HUMAN 117 0 -
Final Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
NPDNCVSHQCQN O00306 276 276 -
KCDPCLSSPCQN O88279 925 925 -
NPDNCVSHQCQN Q99940 275 275 -
NIDECAASPCQN P91526 102 102 -
NIDDCPGHLCQN Q25253 275 275 R2
NIDECAGGPCEH SERR_DROME 491 491 -
DVDECASTPCKN NOTC_BRARE 526 526 R1
AEHACLSDPCHN O14902 336 336 -
AEHACLSDPCHN O15122 336 336 -
AEHACLSDPCHN P78504 336 336 -
AEHACLSDPCHN Q15816 336 336 -
AEHACLSDPCHN Q63722 336 336 -
DFDECTSTPCKN NOTC_XENLA 527 527 R2
DVDECASTPCKN NTC1_RAT 528 528 R1
DVDECASTPCKN NTC1_MOUSE 528 528 R1
EINECDSDPCEN O16004 1009 1009 R2
DGDQCSSNPCHY FA10_CHICK 86 86 -
QLDECASNPCQH O35516 1147 1147 -
DIDECDDDPCYN O16004 475 475 R1
GPDRCKMNPCLN O77609 3074 3074 -
GPDRCKMNPCLN O77610 2087 2087 -
GPDRCKMNPCLN O77611 1336 1336 -
RPDRCKMNPCLN O77612 349 349 -
SAMTCADGPCFN DLL1_RAT 365 365 -
SAMTCADGPCFN DLL1_MOUSE 365 365 -
GPGPCDGNPCAN O88516 272 272 -
GPDRCKMNPCLN PGCV_HUMAN 3089 3089 -
GPDLCKTNPCLN PGCV_MOUSE 3052 3052 -
DVEECDNNPCKH Q25253 199 199 R1
GPGPCDGNPCAN O35675 272 272 -
SAMTCADGPCFN Q90656 373 373 R2
RPDLCKTNPCLN O88564 348 348 -
DEDECKENFCQN Q19350 163 163 -
SAMTCADGPCFN DLL1_HUMAN 366 366 -
SAMTCADGPCFN Q91902 368 368 R2
PYVPCNPSPCLN NOTC_XENLA 217 217 R1
SAMTCADGPCFN O57462 406 406 R2
SAMTCADGPCFN P87357 364 364 R2
SGDFCDSSLCLN MFGM_MOUSE 24 24 -
SGDFCDSSLCLN MFGM_RAT 24 24 -
HCPTCQDRPCQN PGBM_MOUSE 3162 3162 -
HCPTCRDRPCQN PGBM_HUMAN 3846 3846 -
DTDSCELSPCRV LRP1_CHICK 2467 2467 -
DTNSCELSPCRI Q61291 2474 2474 -
NIDECASAPCQN FBP1_STRPU 708 708 R6
DIDECQSSPCVN NTC3_MOUSE 470 470 -
DIDECASAPCQN FBP1_STRPU 784 784 R7
NIDECASAPCQN FBP1_STRPU 290 290 R1
DTDECASQPCQN CRB_DROME 388 388 -
NIDECASAPCQN FBP1_STRPU 366 366 R2
DINECASSPCQN FBP3_STRPU 290 290 R4
DTDECASFPCQN FBP1_STRPU 518 518 R5
NINECLSQPCRN NOTC_BRARE 601 601 R2
EINECDANPCKN Q90656 335 335 R1
DINECASMPCLN FBP1_STRPU 480 480 R4
NVNECHSNPCNN NOTC_DROME 677 677 R1
DIDECASAPCRN FBP3_STRPU 214 214 R2
EINECESQPCLN Q25253 1164 1164 R5
NVNECHSNPCNN Q25253 658 658 R3
DGDQCESNPCLN FA9_HUMAN 93 93 -
DIDECARPPCQN FBP1_STRPU 404 404 R3
EINECLSQPCQN NOTC_BRARE 1181 1181 R3
DINECESNPCVN FBN2_HUMAN 851 851 -
EINECLSHPCQN NOTC_XENLA 1182 1182 R4
DIDECESSPCIN FBN1_BOVIN 807 807 -
DIDECESSPCIN FBN1_HUMAN 807 807 -
EINECLSQPCQN NTC1_MOUSE 1183 1183 R3
NTDDCASFPCQN NOTC_DROME 946 946 R2
EVNECDANPCKN Q91902 330 330 R1
DINECASNPCKN P79941 308 308 -
DINECLSKPCLN NOTC_XENLA 602 602 R3
DVDECTSNPCSN FBN2_MOUSE 528 528 -
EINECLSQPCQN NTC1_RAT 1183 1183 R2
NINECASIPCLN FBP3_STRPU 252 252 R3
EVNECSGSPCRN P87357 326 326 R1
DGDQCASSPCQN FA7_BOVIN 46 46 -
DMDECSSTPCAN NTC4_MOUSE 548 548 -
DMDECSSTPCAN O35442 548 548 -
DGDDCTPNPCLN FBP3_STRPU 176 176 R1
EVNECTGNPCRN O57462 368 368 R1
DTNECASSPCEN O61240 530 530 -
NTDDCAMFPCQN Q25253 927 927 R4
DGDQCESNPCLN FA9_BOVIN 47 47 -
EINECDCNPCKN O57409 310 310 -
NINECHSQPCRH NTC1_MOUSE 603 603 R2

Motif 2 width=8
Element Seqn Id St Int Rpt
GGTCQDRD NTC1_MOUSE 615 0 R2
GRTCADLD Q61291 2978 492 -
GKTCIDID LRP1_CHICK 2974 495 -
GGQCHDSE PGBM_HUMAN 3858 0 -
GGQCQDSE PGBM_MOUSE 3174 0 -
GGTCLMGQ MFGM_RAT 36 0 -
GGTCLTGQ MFGM_MOUSE 36 0 -
GGHCADNP P87357 376 0 R2
GGRCADNP O57462 418 0 R2
GGTCRQTD NOTC_XENLA 229 0 R1
GGRCADNP Q91902 380 0 R2
GGRCSDSP DLL1_HUMAN 378 0 -
GGTCQDAD Q19350 415 240 -
GGTCYPTE O88564 360 0 -
GGRCTDNP Q90656 385 0 R2
GVTCADGP O35675 311 27 -
GGTCLNTH Q25253 211 0 R1
GGTCYPTE PGCV_MOUSE 3064 0 -
GGTCYPTE PGCV_HUMAN 3101 0 -
GVTCADGP O88516 311 27 -
GGRCSDNP DLL1_MOUSE 377 0 -
GGRCSDNP DLL1_RAT 377 0 -
GGTCYPTE O77612 361 0 -
GGTCYPTE O77611 1348 0 -
GGTCYPTE O77610 2099 0 -
GGTCYPTE O77609 3086 0 -
GGTCLNKR O16004 487 0 R1
GATCNDFI O35516 1159 0 -
GGQCKDGL FA10_CHICK 98 0 -
GATCQDRF O16004 1021 0 R2
GAKCLDGP NTC1_MOUSE 540 0 R1
GAKCLDGP NTC1_RAT 540 0 R1
GAKCLDGP NOTC_XENLA 539 0 R2
GGTCQDLV Q63722 386 38 -
GGTCQDLV Q15816 386 38 -
GGTCQDLV P78504 386 38 -
GGTCQDLV O15122 386 38 -
GGTCQDLV O14902 386 38 -
GAKCTDGP NOTC_BRARE 538 0 R1
GGTCIDLI SERR_DROME 503 0 -
GGTCIDGI Q25253 287 0 R2
GATCVDQV P91526 381 267 -
GGTCQDGL Q99940 287 0 -
GGVCVDGI O88279 1017 80 -
GGVCVDGV FBP1_STRPU 720 0 R6
GGTCVDGV NTC3_MOUSE 937 455 -
GGVCTDTI FBP1_STRPU 796 0 R7
GGICIDGI FBP1_STRPU 302 0 R1
GGTCLDKP CRB_DROME 476 76 -
GGVCIDGV FBP1_STRPU 378 0 R2
GGSCTDAV FBP3_STRPU 302 0 R4
GATCTDQV FBP1_STRPU 530 0 R5
GGTCQDRE NOTC_BRARE 613 0 R2
GGSCTDLE Q90656 347 0 R1
GGVCTDLV FBP1_STRPU 492 0 R4
GATCIDGI NOTC_DROME 689 0 R1
GGACVDQV FBP3_STRPU 226 0 R2
GGTCRDLI Q25253 1176 0 R5
GATCIDGI Q25253 670 0 R3
GGSCKDDI FA9_HUMAN 105 0 -
GGDCVDGV FBP1_STRPU 416 0 R3
GGTCIDLV NOTC_BRARE 1193 0 R3
GGTCVNTE FBN2_HUMAN 1170 307 -
GGTCIDLI NOTC_XENLA 1194 0 R4
GFTCTDLD FBN1_BOVIN 1399 580 -
GFTCTDLD FBN1_HUMAN 1399 580 -
GGTCIDLT NTC1_MOUSE 1195 0 R3
GGTCLDGI NOTC_DROME 958 0 R2
GGSCSDLE Q91902 342 0 R1
GGSCNDLE P79941 320 0 -
GGQCTDRE NOTC_XENLA 614 0 R3
GGTCVNTE FBN2_MOUSE 1164 624 -
GGTCIDLT NTC1_RAT 1195 0 R2
GGICVDGI FBP3_STRPU 264 0 R3
GGSCTDLE P87357 338 0 R1
GGSCEDQL FA7_BOVIN 58 0 -
GGLCIDTG NTC4_MOUSE 900 340 -
GGLCIDTG O35442 900 340 -
GATCVDQV FBP3_STRPU 188 0 R1
GGSCTDME O57462 380 0 R1
GGTCTDEI O61240 542 0 -
GGTCLDGI Q25253 939 0 R4
GGMCKDDI FA9_BOVIN 59 0 -
GGSCNDLE O57409 322 0 -
GGTCQDGL O00306 288 0 -

Motif 3 width=11
Element Seqn Id St Int Rpt
GSFNCLCPPGY O00306 457 161 -
NGYVCNCAPGY FBP1_STRPU 728 0 R6
GGYVCECPAGY NTC3_MOUSE 1105 160 -
NGYICACVPGF FBP1_STRPU 804 0 R7
NGYTCSCPLGF FBP1_STRPU 310 0 R1
GTYTCECEPGF CRB_DROME 924 440 -
NGYMCDCQPGY FBP1_STRPU 386 0 R2
NRYTCDCRAGF FBP3_STRPU 310 0 R4
NGYVCTCVPGY FBP1_STRPU 538 0 R5
NAYICTCPKGT NOTC_BRARE 621 0 R2
NSYSCTCPPGF Q90656 355 0 R1
NGYICTCAAGF FBP1_STRPU 500 0 R4
NSYKCQCVPGF NOTC_DROME 697 0 R1
NGYTCNCIPGF FBP3_STRPU 234 0 R2
GSYACVCRKGF Q25253 1184 0 R5
NKYTCQCVPGF Q25253 678 0 R3
NSYECWCPFGF FA9_HUMAN 113 0 -
NGYVCICAPGF FBP1_STRPU 424 0 R3
NTYKCSCPRGT NOTC_BRARE 1201 0 R3
GSYNCLCYPGF FBN2_HUMAN 1952 774 -
NTYKCSCPRGT NOTC_XENLA 1202 0 R4
GSYRCICPPGY FBN1_BOVIN 1994 587 -
GSYRCICPPGY FBN1_HUMAN 1994 587 -
NSYKCSCPRGT NTC1_MOUSE 1203 0 R3
GDYSCLCVDGF NOTC_DROME 966 0 R2
NSYTCSCPPGF Q91902 350 0 R1
NDYECVCPRGF P79941 328 0 -
NGYICTCPKGT NOTC_XENLA 622 0 R3
GSYNCLCYPGF FBN2_MOUSE 1946 774 -
NTYKCSCPRGT NTC1_RAT 1203 0 R2
NQFACTCLPGY FBP3_STRPU 272 0 R3
NTYSCTCPPGF P87357 346 0 R1
RSYICFCPDGF FA7_BOVIN 66 0 -
SSYFCRCPPGF NTC4_MOUSE 908 0 -
SSYFCRCPPGF O35442 908 0 -
NDYQCICAPGF FBP3_STRPU 196 0 R1
NTYSCTCPPGF O57462 388 0 R1
GYYTCTCPTGT O61240 550 0 -
GDYTCLCVDGF Q25253 947 0 R4
NSYECWCQAGF FA9_BOVIN 67 0 -
NDYSCTCPQGF O57409 330 0 -
NSYLCLCLKGT NTC1_MOUSE 623 0 R2
NSYACLCAEGY O88279 1103 78 -
GSFNCLCPPGY Q99940 456 161 -
PSYECRCKPGY P91526 1177 788 -
NSYHCACPPNY Q25253 295 0 R2
NDYRCACASGF SERR_DROME 630 119 -
NKYTCECTPGF NOTC_BRARE 546 0 R1
NGYRCICPPGY O14902 469 75 -
NGYRCICPPGY O15122 469 75 -
NGYRCICPPGY P78504 469 75 -
NGYRCICPPGY Q15816 469 75 -
NGYRCICPPGY Q63722 469 75 -
NSYTCQCTEGF NOTC_XENLA 547 0 R2
NTYTCVCTEGY NTC1_RAT 548 0 R1
NTYTCVCTEGY NTC1_MOUSE 548 0 R1
GSYSCHCDVGF O16004 1029 0 R2
GSYTCSCLDGY FA10_CHICK 106 0 -
GGYRCECVPGY O35516 1167 0 -
GGYACICLTGF O16004 495 0 R1
TSYVCTCVPGY O77609 3094 0 -
TSYVCTCVPGY O77610 2107 0 -
TSYVCTCVPGY O77611 1356 0 -
TSYVCTCVPGY O77612 369 0 -
GGYTCHCPAGF DLL1_RAT 386 1 -
GGYTCHCPLGF DLL1_MOUSE 386 1 -
SAYVCHCPPGF O88516 333 14 -
TSYVCTCVPGY PGCV_HUMAN 3109 0 -
TSYVCTCAPGY PGCV_MOUSE 3072 0 -
GSYQCMCPAGY Q25253 219 0 R1
SXYVCHCPPGF O35675 333 14 -
GGYSCRCPLGY Q90656 394 1 R2
TSYVCTCAPGY O88564 368 0 -
TGYKCTCAVGF Q19350 1501 1078 -
GGYSCRCPVGY DLL1_HUMAN 387 1 -
GGYICFCPVGY Q91902 389 1 R2
TSYDCTCLPGF NOTC_XENLA 238 1 R1
GGYFCQCPTGY O57462 427 1 R2
GGYFCQCPMGY P87357 385 1 R2
TEYICQCPVGY MFGM_MOUSE 92 48 -
TEYICQCPVGY MFGM_RAT 92 48 -
SSYTCVCPAGF PGBM_MOUSE 3183 1 -
SSYVCVCPAGF PGBM_HUMAN 3867 1 -
GSYKCLCIEGY LRP1_CHICK 2998 16 -
GSYKCLCVEGY Q61291 3002 16 -

Motif 4 width=7
Element Seqn Id St Int Rpt
YGKNCEL Q90656 366 0 R1
SGIHCEL NOTC_BRARE 557 0 R1
TGRDCET SERR_DROME 641 0 -
TGENCEK Q25253 306 0 R2
SGDRCEL P91526 1225 37 -
TGQLCEV Q99940 619 152 -
SGQLCEI O88279 1114 0 -
TGQLCEV O00306 620 152 -
TGPNCEI NTC1_MOUSE 634 0 R2
YGKNCEI O57409 341 0 -
EGTNCEL FA9_BOVIN 78 0 -
DGKHCET Q25253 958 0 R4
SGSSCEI O61240 561 0 -
YGKNCEL O57462 399 0 R1
TGDNCET FBP3_STRPU 207 0 R1
TGQRCEV O35442 1035 116 -
TGQRCEV NTC4_MOUSE 1035 116 -
EGRNCET FA7_BOVIN 77 0 -
YGRNCEL P87357 357 0 R1
TGILCET FBP3_STRPU 283 0 R3
QGVHCEI NTC1_RAT 1214 0 R2
SGLNCED FBN2_MOUSE 2601 644 -
TGVNCET NOTC_XENLA 633 0 R3
HGSNCEK P79941 379 40 -
YGKNCEL Q91902 361 0 R1
DGKHCET NOTC_DROME 977 0 R2
QGVHCEI NTC1_MOUSE 1214 0 R3
TGSSCED FBN1_HUMAN 2561 556 -
TGASCED FBN1_BOVIN 2561 556 -
QGVHCEI NOTC_XENLA 1213 0 R4
TGLNCED FBN2_HUMAN 2607 644 -
QGVHCEI NOTC_BRARE 1212 0 R3
TGDKCEL Q61291 4228 1215 -
DGLNCEN FBP1_STRPU 435 0 R3
EGKNCEL FA9_HUMAN 124 0 -
TGMRCEE LRP1_CHICK 4404 1395 -
TGSRCEH PGBM_HUMAN 3878 0 -
SGVRCEE PGBM_MOUSE 3234 40 -
TGVHCEI Q25253 689 0 R3
QGQNCEL Q25253 1195 0 R5
NGVNCEN FBP3_STRPU 245 0 R2
TGQHCEK NOTC_DROME 708 0 R1
SGIHCEL MFGM_RAT 103 0 -
EGTNCET FBP1_STRPU 511 0 R4
AGFNCEK P87357 396 0 R2
SGIHCET MFGM_MOUSE 103 0 -
TGDNCET FBP1_STRPU 739 0 R6
TGLHCEA NTC3_MOUSE 1199 83 -
TGSNCET FBP1_STRPU 815 0 R7
SGDNCEN FBP1_STRPU 321 0 R1
TGRLCEQ CRB_DROME 1946 1011 -
TGTHCET FBP1_STRPU 397 0 R2
TGSNCET FBP3_STRPU 321 0 R4
TGVLCET FBP1_STRPU 549 0 R5
TGVNCEI NOTC_BRARE 632 0 R2
EGAYCET O14902 660 180 -
EGAYCET O15122 660 180 -
EGAYCET P78504 660 180 -
EGAYCET Q15816 660 180 -
EGAHCEN Q63722 660 180 -
TGRHCEQ NOTC_XENLA 558 0 R2
TGTHCEV NTC1_RAT 559 0 R1
TGTHCEV NTC1_MOUSE 559 0 R1
TGLNCEH O16004 1040 0 R2
QGKNCEF FA10_CHICK 117 0 -
QGVNCEY O35516 1178 0 -
TGTLCET O16004 506 0 R1
SGDRCEL O77609 3105 0 -
SGDRCEL O77610 2118 0 -
SGDRCEL O77611 1367 0 -
SGDRCEL O77612 380 0 -
SGFNCEK DLL1_RAT 397 0 -
SGFNCEK DLL1_MOUSE 397 0 -
QGSNCEK O88516 344 0 -
SGDQCEL PGCV_HUMAN 3120 0 -
SGDQCEL PGCV_MOUSE 3083 0 -
TGKNCES Q25253 230 0 R1
QGSNCEK O35675 344 0 -
SGFNCEK Q90656 405 0 R2
SGDQCEL O88564 379 0 -
EGADCEI Q19350 1512 0 -
SGFNCEK DLL1_HUMAN 398 0 -
SGFNCEK Q91902 400 0 R2
SGQNCEE NOTC_XENLA 249 0 R1
AGFNCEK O57462 438 0 R2