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PR01965

Identifier
TNFACTORR14  [View Relations]  [View Alignment]  
Accession
PR01965
No. of Motifs
4
Creation Date
23-JUN-2009
Title
Tumour necrosis factor receptor 14 signature
Database References

MIM; 602746
Literature References
1. ARMITAGE, R.
Tumor necrosis factor receptor superfamily members and their ligands.
CURR.OPIN.IMMUNOL. 6 407-413 (1994).
 
2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
LOETSCHER, H. AND LESSLAUER, W.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
complex: implications for TNF receptor activation.
CELL 73 431-445 (1993).
 
3. WU, H.
Assembly of post-receptor signaling complexes for the tumor necrosis factor
receptor superfamily.
ADV.PROTEIN CHEM. 68 225-279 (2004).
 
4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
CELL 104 487-501 (2001).
 
5. GRAVESTEIN, L. AND BORST, J.
Tumor necrosis factor receptor family members in the immune system.
SEMIN.IMMUNOL. 10 423-434 (1998).
 
6. LOENEN, W.
D27 and (TNFR) relatives in the immune system: their role in health and
disease.
SEMIN.IMMUNOL. 10 417-422 (1998).
 
7. MONTGOMERY, R., WARNER, M., LUM, B. AND SPEAR, P.
Herpes simplex virus-1 entry into cells mediated by a novel member of the 
TNF/NGF receptor family.
CELL 87 427-436 (1996).

Documentation
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
than 20 type-I transmembrane proteins. Family members are defined based on
similarity in their extracellular domain - a region that contains many
cysteine residues arranged in a specific repetitive pattern [1]. The
cysteines allow formation of an extended rod-like structure, responsible for
ligand binding [2].
 
Upon receptor activation, different intracellular signalling complexes are
assembled for different members of the TNFR superfamily, depending on their
intracellular domains and sequences [3]. Activation of TNFRs can therefore
induce a range of disparate effects, including cell proliferation,
differentiation, survival, or apoptotic cell death, depending upon the
receptor involved [4,5].
 
TNFRs are widely distributed and play important roles in many crucial
biological processes, such as lymphoid and neuronal development, innate and
adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
manipulate their signalling have potential roles in the prevention and
treatment of many diseases, such as viral infections, coronary heart
disease, transplant rejection, and immune disease [6].
 
TNF receptor 14 is also known as herpesvirus entry mediator (HVEM). It plays
an important role in the entry of herpes simplex virus into cells, and hence
pathogenesis of the virus [7].
 
TNFACTORR14 is a 3-element fingerprint that provides a signature for tumour
necrosis factor receptor 14. The fingerprint was derived from an initial
alignment of 6 sequences: the motifs were drawn from conserved regions in
the N-terminal half of the alignment, focusing on those sections that
characterise TNF receptor 14 but distinguish it from other TNF receptor
subtypes - all motifs lie in the extracellular N-terminal region. Two 
iterations on SPTR57_40f were required to reach convergence, at which point
a true set comprising 11 sequences was identified. Two partial matches were
also found, B4DU65_HUMAN and B4E0P6_HUMAN, both which are translated human
cDNA sequences that fail to match motif 4.
Summary Information
  11 codes involving  4 elements
2 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
411111111
32220
20000
1234
True Positives
B8LFF5_HORSE  B9A034_HUMAN  B9DI89_HUMAN  Q0MSE4_MACMU  
Q3SXX1_MOUSE Q4G265_HORSE Q5BK53_RAT Q71F55_MOUSE
Q80WM9_MOUSE Q9XSZ8_CERAE TNR14_HUMAN
True Positive Partials
Codes involving 3 elements
B4DU65_HUMAN B4E0P6_HUMAN
Sequence Titles
B8LFF5_HORSE ELR1-insert - Equus caballus (Horse).         
B9A034_HUMAN Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) - Homo sapiens (Human).
B9DI89_HUMAN Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) - Homo sapiens (Human).
Q0MSE4_MACMU Herpesvirus entry mediator - Macaca mulatta (Rhesus macaque).
Q3SXX1_MOUSE Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) - Mus musculus (Mouse).
Q4G265_HORSE ELR1 - Equus caballus (Horse).
Q5BK53_RAT Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) - Rattus norvegicus (Rat).
Q71F55_MOUSE Herpes virus entry mediator - Mus musculus (Mouse).
Q80WM9_MOUSE Tumor necrosis factor receptor superfamily member 14 - Mus musculus (Mouse).
Q9XSZ8_CERAE HveAs - Cercopithecus aethiops (Green monkey) (Grivet).
TNR14_HUMAN Tumor necrosis factor receptor superfamily member 14 - Homo sapiens (Human).

B4DU65_HUMAN cDNA FLJ57170, highly similar to Tumor necrosis factor receptor superfamily member 14 - Homo sapiens (Human).
B4E0P6_HUMAN cDNA FLJ56728, highly similar to Tumor necrosis factor receptor superfamily member 14 - Homo sapiens (Human).
Scan History
SPTR57_40f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
MEPPGDWGPPPWRST TNR14_HUMAN 1 1 -
MEPLPGWGSAPWSQA Q80WM9_MOUSE 1 1 -
MEPPGGWGSPPRRPA Q0MSE4_MACMU 1 1 -
MEPPGGWGSPPRRPA Q9XSZ8_CERAE 1 1 -
MEPLPGWESSPWSRA Q5BK53_RAT 1 1 -
MEPLRGWGPPPWSPA Q4G265_HORSE 1 1 -

Motif 2 width=15
Element Seqn Id St Int Rpt
GYRVKEACGELTGTV TNR14_HUMAN 60 44 -
GYHVKQVCSEHTGTV Q80WM9_MOUSE 60 44 -
GFHVRQACGEQTGTV Q0MSE4_MACMU 60 44 -
GFHVRQACGEQTGTV Q9XSZ8_CERAE 60 44 -
GYHVKQVCSEHTGTV Q5BK53_RAT 58 42 -
GYRVKQACGELTGTV Q4G265_HORSE 60 44 -

Motif 3 width=15
Element Seqn Id St Int Rpt
TYIAHLNGLSKCLQC TNR14_HUMAN 82 7 -
TYTAHANGLSKCLPC Q80WM9_MOUSE 82 7 -
TYIAHFNGLSKCLQC Q0MSE4_MACMU 82 7 -
TYIAHFNGLSKCLQC Q9XSZ8_CERAE 82 7 -
TYTAHANGLSKCLPC Q5BK53_RAT 80 7 -
TFSAHLNGLSKCLPC Q4G265_HORSE 82 7 -

Motif 4 width=13
Element Seqn Id St Int Rpt
FCIVQDGDHCAAC TNR14_HUMAN 126 29 -
FCENQDGSHCSTC Q80WM9_MOUSE 126 29 -
FCIIQDGDHCAAC Q0MSE4_MACMU 126 29 -
FCIIQDGDHCAAC Q9XSZ8_CERAE 126 29 -
FCENQDGGACSTC Q5BK53_RAT 124 29 -
FCVSEKGDDCVEC Q4G265_HORSE 126 29 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
MEPPGDWGPPPWRST B9A034_HUMAN 1 1 -
MEPPGDWGPPPWRST TNR14_HUMAN 1 1 -
MEPPGDWGPPPWRST B9DI89_HUMAN 1 1 -
MEPLPGWGSAPWSQA Q3SXX1_MOUSE 1 1 -
MEPLPGWGSAPWSQA Q80WM9_MOUSE 1 1 -
MEPLPGWGSAPWSQA Q71F55_MOUSE 1 1 -
MEPPGGWGSPPRRPA Q0MSE4_MACMU 1 1 -
MEPPGGWGSPPRRPA Q9XSZ8_CERAE 1 1 -
MEPLPGWESSPWSRA Q5BK53_RAT 1 1 -
MEPLRGWGPPPWSPA B8LFF5_HORSE 1 1 -
MEPLRGWGPPPWSPA Q4G265_HORSE 1 1 -

Motif 2 width=15
Element Seqn Id St Int Rpt
GYRVKEACGELTGTV B9A034_HUMAN 60 44 -
GYRVKEACGELTGTV TNR14_HUMAN 60 44 -
GYRVKEACGELTGTV B9DI89_HUMAN 60 44 -
GYHVKQVCSEHTGTV Q3SXX1_MOUSE 60 44 -
GYHVKQVCSEHTGTV Q80WM9_MOUSE 60 44 -
GYHVKQVCSEHTGTV Q71F55_MOUSE 60 44 -
GFHVRQACGEQTGTV Q0MSE4_MACMU 60 44 -
GFHVRQACGEQTGTV Q9XSZ8_CERAE 60 44 -
GYHVKQVCSEHTGTV Q5BK53_RAT 58 42 -
GYRVKQACGELTGTV B8LFF5_HORSE 60 44 -
GYRVKQACGELTGTV Q4G265_HORSE 60 44 -

Motif 3 width=15
Element Seqn Id St Int Rpt
TYIAHLNGLSKCLQC B9A034_HUMAN 82 7 -
TYIAHLNGLSKCLQC TNR14_HUMAN 82 7 -
TYIAHLNGLSKCLQC B9DI89_HUMAN 82 7 -
TYTAHANGLSKCLPC Q3SXX1_MOUSE 82 7 -
TYTAHANGLSKCLPC Q80WM9_MOUSE 82 7 -
TYTAHANGLSKCLPC Q71F55_MOUSE 82 7 -
TYIAHFNGLSKCLQC Q0MSE4_MACMU 82 7 -
TYIAHFNGLSKCLQC Q9XSZ8_CERAE 82 7 -
TYTAHANGLSKCLPC Q5BK53_RAT 80 7 -
TFSAHLNGLSKCLPC B8LFF5_HORSE 82 7 -
TFSAHLNGLSKCLPC Q4G265_HORSE 82 7 -

Motif 4 width=13
Element Seqn Id St Int Rpt
FCIVQDGDHCAAC B9A034_HUMAN 126 29 -
FCIVQDGDHCAAC TNR14_HUMAN 126 29 -
FCIVQDGDHCAAC B9DI89_HUMAN 126 29 -
FCENQDGSHCSTC Q3SXX1_MOUSE 126 29 -
FCENQDGSHCSTC Q80WM9_MOUSE 126 29 -
FCENQDGSHCSTC Q71F55_MOUSE 126 29 -
FCIIQDGDHCAAC Q0MSE4_MACMU 126 29 -
FCIIQDGDHCAAC Q9XSZ8_CERAE 126 29 -
FCENQDGGACSTC Q5BK53_RAT 124 29 -
FCVSEKGDDCVEC B8LFF5_HORSE 126 29 -
FCVSEKGDDCVEC Q4G265_HORSE 126 29 -