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PR01929

Identifier
INTRLEUKIN13  [View Relations]  [View Alignment]  
Accession
PR01929
No. of Motifs
4
Creation Date
24-JUL-2008
Title
Interleukin-13 signature
Database References

PFAM; PF03487 IL13
PRODOM; PD015987
INTERPRO; IPR003634
PDB; 1IJZ; IGA3; 1IK0
SCOP; 1IJZ; IGA3; 1IK0
CATH; 1IJZ; IGA3; 1IK0
MIM; 147683
Literature References
1. MINTY, A., CHALON, P., DEROCQ, J., DUMONT, X., GUILLEMOT, J.,
KAGHAD, M., LABIT, C., LEPLATOIS, P., LIAUZUN, P. AND MILOUX, B. 
Interleukin-13 is a new human lymphokine regulating inflammatory and immune
responses. 
NATURE 362 248-250 (1993).
 
2. WILLIS-KARP, M., LUYIMBAZI, J., XU, X., SCHOFIELD, B., NEBEN, T.,
KARP, C. AND DONALDSON, D.
Interleukin-13: central mediator of allergic asthma. 
SCIENCE 282 2258-2261 (1998).

Documentation
Interleukins (IL) are a group of cytokines that play an important role in
the immune system. They modulate inflammation and immunity by regulating
growth, mobility and differentiation of lymphoid and other cells.
 
Interleukin-13 (IL-13) inhibits inflammatory cytokine production and 
synergises with IL-2 in regulating interferon-gamma synthesis [1]. It has 
been identified as a central mediator of allergic asthma [2].
 
INTRLEUKIN13 is a 4-element fingerprint that provides a signature for 
interleukin-13. The fingerprint was derived from an initial alignment of 4
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motifs 1, 3 and 4 encompassing short helical 
regions. Two iterations on SPTR55_38f were required to reach convergence, at
which point a true set comprising 22 sequences was identified. Two partial
matches were also found, Q4VB51_HUMAN and Q4VB53_HUMAN, both of which are 
translated human cDNA sequences that fail to match motif 1.
Summary Information
  22 codes involving  4 elements
2 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
422222222
30222
20000
1234
True Positives
A9CB12_PAPAN  A9QWR5_BOVIN  IL13_BOVIN    IL13_CAMBA    
IL13_CANFA IL13_HUMAN IL13_LAMGL IL13_MACMU
IL13_MACTH IL13_MOUSE IL13_PANTR IL13_PIG
IL13_RAT Q0PW91_SHEEP Q0PW92_MACFA Q0ZB83_MACNE
Q0ZB84_CERTO Q3I5F5_BUBBU Q4VB50_HUMAN Q4VB52_HUMAN
Q5SUZ9_MOUSE Q7TNZ2_SIGHI
True Positive Partials
Codes involving 3 elements
Q4VB51_HUMAN Q4VB53_HUMAN
Sequence Titles
A9CB12_PAPAN Interleukin 13 (Predicted) - Papio anubis (Olive baboon). 
A9QWR5_BOVIN Interleukin 13 - Bos taurus (Bovine).
IL13_BOVIN Interleukin-13 precursor (IL-13) - Bos taurus (Bovine).
IL13_CAMBA Interleukin-13 precursor (IL-13) - Camelus bactrianus (Bactrian camel).
IL13_CANFA Interleukin-13 precursor (IL-13) - Canis familiaris (Dog).
IL13_HUMAN Interleukin-13 precursor (IL-13) - Homo sapiens (Human).
IL13_LAMGL Interleukin-13 precursor (IL-13) - Lama glama (Llama).
IL13_MACMU Interleukin-13 precursor (IL-13) - Macaca mulatta (Rhesus macaque).
IL13_MACTH Interleukin-13 precursor (IL-13) - Macaca thibetana (Pere David's macaque) (Tibetan macaque).
IL13_MOUSE Interleukin-13 precursor (IL-13) (T-cell activation protein P600) - Mus musculus (Mouse).
IL13_PANTR Interleukin-13 precursor (IL-13) - Pan troglodytes (Chimpanzee).
IL13_PIG Interleukin-13 precursor (IL-13) - Sus scrofa (Pig).
IL13_RAT Interleukin-13 precursor (IL-13) (T-cell activation protein P600) - Rattus norvegicus (Rat).
Q0PW91_SHEEP IL13 - Ovis aries (Sheep).
Q0PW92_MACFA IL13 - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Q0ZB83_MACNE Interleukin 13 - Macaca nemestrina (Pig-tailed macaque).
Q0ZB84_CERTO Interleukin 13 - Cercocebus torquatus atys (Red-crowned mangabey) (Sooty mangabey).
Q3I5F5_BUBBU Interleukin-13 - Bubalus bubalis (Domestic water buffalo).
Q4VB50_HUMAN Interleukin 13 - Homo sapiens (Human).
Q4VB52_HUMAN Interleukin 13 - Homo sapiens (Human).
Q5SUZ9_MOUSE Interleukin 13 - Mus musculus (Mouse).
Q7TNZ2_SIGHI Interleukin 13 - Sigmodon hispidus (Hispid cotton rat).

Q4VB51_HUMAN IL13 protein - Homo sapiens (Human).
Q4VB53_HUMAN IL13 protein - Homo sapiens (Human).
Scan History
SPTR55_38f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
RELIEELVNITQNQKAPLC IL13_HUMAN 30 30 -
KELIEELVNITQNQKAPLC IL13_CAMBA 30 30 -
KELIEELVNITQNQKVPLC IL13_BOVIN 30 30 -
RELIEELSNITQDQKTSLC IL13_RAT 34 34 -

Motif 2 width=22
Element Seqn Id St Int Rpt
MVWSINLTAGMYCAALESLINV IL13_HUMAN 52 3 -
MVWSINLTTSMYCAARESLINI IL13_CAMBA 52 3 -
MVWSLNLTSSMYCAALDSLISI IL13_BOVIN 52 3 -
MVWSVDLTAGGFCAALESLTNI IL13_RAT 56 3 -

Motif 3 width=13
Element Seqn Id St Int Rpt
CSAIEKTQRMLSG IL13_HUMAN 76 2 -
CSVIQRTQRMLNA IL13_CAMBA 76 2 -
CSVIQRTKKMLNA IL13_BOVIN 76 2 -
CNAIHRTQRILNG IL13_RAT 80 2 -

Motif 4 width=14
Element Seqn Id St Int Rpt
DTKIEVAQFVKDLL IL13_HUMAN 106 17 -
DTKIEVTQFIKTLL IL13_CAMBA 105 16 -
DTKIEVAQFLKDLL IL13_BOVIN 106 17 -
DTKIEVAQFISKLL IL13_RAT 107 14 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
KELIEELVNITQNQKAPLC IL13_MACMU 30 30 -
KELIEELVNITQNQKAPLC Q0ZB84_CERTO 30 30 -
KELIEELVNITQNQKAPLC Q0ZB83_MACNE 30 30 -
KELIEELVNITQNQKAPLC Q0PW92_MACFA 30 30 -
KELIEELVNITQNQKAPLC IL13_MACTH 30 30 -
RELIEELVNITQNQKAPLC A9CB12_PAPAN 30 30 -
RELIEELVNITQNQKAPLC IL13_HUMAN 30 30 -
RELIEELVNITQNQKAPLC Q4VB52_HUMAN 44 44 -
RELIEELVNITQNQKAPLC Q4VB50_HUMAN 30 30 -
RELIEELVNITQNQKAPLC IL13_PANTR 30 30 -
KELIEELVNITQNQKAPLC IL13_CAMBA 30 30 -
KELIEELVNITQNQKAPLC IL13_LAMGL 30 30 -
KELIEELVNITQNQKVPLC A9QWR5_BOVIN 30 30 -
KELIEELVNITQNQKVPLC Q3I5F5_BUBBU 30 30 -
KELIEELVNITQNQKVPLC Q0PW91_SHEEP 30 30 -
KELIEELVNITQNQKVPLC IL13_BOVIN 30 30 -
KELIEELVNITQNQKTPLC IL13_PIG 31 31 -
KELIEELVNITQNQASLCN IL13_CANFA 30 30 -
RELIEELSNITQDQKTSLC IL13_RAT 34 34 -
KELIEELSNITQDQRAPLC Q7TNZ2_SIGHI 34 34 -
KELIEELSNITQDQTPLCN IL13_MOUSE 34 34 -
KELIEELSNITQDQTPLCN Q5SUZ9_MOUSE 34 34 -

Motif 2 width=22
Element Seqn Id St Int Rpt
MVWSINLTAGVYCAALESLINV IL13_MACMU 52 3 -
MVWSINLTAGVYCAALESLINV Q0ZB84_CERTO 52 3 -
MVWSINLTAGVYCAALESLINV Q0ZB83_MACNE 52 3 -
MVWSINLTAGVYCAALESLINV Q0PW92_MACFA 52 3 -
MVWSINLTAGVYCAALESLINV IL13_MACTH 52 3 -
MVWSINLTAGVYCAALESLINV A9CB12_PAPAN 52 3 -
MVWSINLTAGMYCAALESLINV IL13_HUMAN 52 3 -
MVWSINLTAGMYCAALESLINV Q4VB52_HUMAN 66 3 -
MVWSINLTAGMYCAALESLINV Q4VB50_HUMAN 52 3 -
MVWSINLTAGVYCAALESLINV IL13_PANTR 52 3 -
MVWSINLTTSMYCAARESLINI IL13_CAMBA 52 3 -
MVWSINLTTSMYCAARESLINI IL13_LAMGL 52 3 -
MVWSLNLTSSMYCAALDSLISI A9QWR5_BOVIN 52 3 -
MVWSLNLTSSMYCAALDSLISI Q3I5F5_BUBBU 52 3 -
MVWSLNLTSSMYCAALDSLISI Q0PW91_SHEEP 52 3 -
MVWSLNLTSSMYCAALDSLISI IL13_BOVIN 52 3 -
VWSVNLTTSMQYCAALESLINI IL13_PIG 54 4 -
MVWSVNLTAGMYCAALESLINV IL13_CANFA 51 2 -
MVWSVDLTAGGFCAALESLTNI IL13_RAT 56 3 -
MVWSVDLTAGGFCGALDSLTNI Q7TNZ2_SIGHI 56 3 -
MVWSVDLAAGGFCVALDSLTNI IL13_MOUSE 55 2 -
MVWSVDLAAGGFCVALDSLTNI Q5SUZ9_MOUSE 55 2 -

Motif 3 width=13
Element Seqn Id St Int Rpt
CSAIEKTQRMLNG IL13_MACMU 76 2 -
CSAIEKTQRMLNG Q0ZB84_CERTO 76 2 -
CSAIEKTQRMLNG Q0ZB83_MACNE 76 2 -
CSAIEKTQRMLNG Q0PW92_MACFA 76 2 -
CSAIEKTQRMLNG IL13_MACTH 76 2 -
CSAIEKTQRMLNG A9CB12_PAPAN 76 2 -
CSAIEKTQRMLSG IL13_HUMAN 76 2 -
CSAIEKTQRMLSG Q4VB52_HUMAN 90 2 -
CSAIEKTQRMLSG Q4VB50_HUMAN 76 2 -
CSAIEKTQRMLSG IL13_PANTR 76 2 -
CSVIQRTQRMLNA IL13_CAMBA 76 2 -
CSVIQRTQRMLNA IL13_LAMGL 76 2 -
CSVIQRTKRMLNA A9QWR5_BOVIN 76 2 -
CSVIQRTKRMLNA Q3I5F5_BUBBU 76 2 -
CSVIHRTKRMLSA Q0PW91_SHEEP 76 2 -
CSVIQRTKKMLNA IL13_BOVIN 76 2 -
CSAIQKTQRMLSA IL13_PIG 78 2 -
CSAIQRTQRMLKA IL13_CANFA 75 2 -
CNAIHRTQRILNG IL13_RAT 80 2 -
CKPIYKTQRLLNA Q7TNZ2_SIGHI 80 2 -
CNAIYRTQRILHG IL13_MOUSE 79 2 -
CNAIYRTQRILHG Q5SUZ9_MOUSE 79 2 -

Motif 4 width=14
Element Seqn Id St Int Rpt
DTKIEVAQFVKDLL IL13_MACMU 106 17 -
DTKIEVAQFVKDLL Q0ZB84_CERTO 106 17 -
DTKIEVAQFVKDLL Q0ZB83_MACNE 106 17 -
DTKIEVAQFVKDLL Q0PW92_MACFA 106 17 -
DTKIEVAQFVKDLL IL13_MACTH 106 17 -
DTKIEVAQFVKDLL A9CB12_PAPAN 106 17 -
DTKIEVAQFVKDLL IL13_HUMAN 106 17 -
DTKIEVAQFVKDLL Q4VB52_HUMAN 120 17 -
DTKIEVAQFVKDLL Q4VB50_HUMAN 106 17 -
DTKIEVAQFVKDLL IL13_PANTR 106 17 -
DTKIEVTQFIKTLL IL13_CAMBA 105 16 -
DTKIEVTQFIKTLL IL13_LAMGL 105 16 -
DTKIEVAQFLKDLL A9QWR5_BOVIN 106 17 -
DTKIEVAQFLKDLL Q3I5F5_BUBBU 106 17 -
DTKIEVAQFLKDLL Q0PW91_SHEEP 106 17 -
DTKIEVAQFLKDLL IL13_BOVIN 106 17 -
DTKIEVAQFVKDLL IL13_PIG 108 17 -
DTKIEVIQLVKNLL IL13_CANFA 105 17 -
DTKIEVAQFISKLL IL13_RAT 107 14 -
DTKIEVVQFITTLL Q7TNZ2_SIGHI 107 14 -
DTKIEVAHFITKLL IL13_MOUSE 106 14 -
DTKIEVAHFITKLL Q5SUZ9_MOUSE 106 14 -