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PR01908

Identifier
ADSPHPHTASE  [View Relations]  [View Alignment]  
Accession
PR01908
No. of Motifs
4
Creation Date
11-MAY-2006
Title
Atypical dual specificity phosphatase family signature
Database References
PRINTS; PR00700 PRTYPHPHTASE; PR01764 MAPKPHPHTASE; PR01909 ADSPHPHTASEA
PRINTS; PR01910 ADSPHPHTASEB
INTERPRO; IPR000340
PDB; 1J4X; 1VHR
SCOP; 1J4X; 1VHR
CATH; 1J4X; 1VHR
Literature References
1. ISHIBASHI, T., BOTTARO, D.P., CHAN, A., MIKI, T. AND AARONSON, S.A. 
Expression cloning of a human dual-specificity phosphatase. 
PROC.NATL.ACAD.SCI.U.S.A. 89 12170-12174 (1992). 
 
2. YUVANIYAMA, J., DENU, J.M., DIXON, J.E. AND SAPER, M.A. 
Crystal structure of the dual specificity protein phosphatase VHR. 
SCIENCE 272 1328-1331 (1996). 
 
3. TODD, J.L., TANNER, K.G. AND DENU, J.M. 
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates 
for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in 
down-regulating the ERK pathway.
J.BIOL.CHEM. 274(19) 13271-80 (1999).
 
4. TODD, J.L., RIGAS, J.D., RAFTY, L.A. AND DENU, J.M. 
Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun 
N-terminal kinase (JNK).
ONCOGENE 21(16) 2573-83 (2002).
 
5. VASUDEVAN, S.A., SKOKO, J., WANG, K., BURLINGAME, S.M., PATEL, P.N., 
LAZO, J.S., NUCHTERN, J.G. AND YANG, J. 
MKP-8, a novel MAPK phosphatase that inhibits p38 kinase.
BIOCHEM.BIOPHYS.RES.COMMUN. 330(2) 511-8 (2005).
 
6. RAHMOUNI, S., CERIGNOLI, F., ALONSO, A., TSUTJI, T., HENKENS, R., 
ZHU, C., LOUIS-DIT-SULLY, C., MOUTSCHEN, M., JIANG, W. AND MUSTELIN, T. 
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and
senescence.
NAT.CELL BIOL. 8(5) 524-31 (2006). 

Documentation
Dual Specificity Phosphatases (DUSPs) are members of the superfamily of 
Protein Tyrosine Phosphatases (PTPs). They remove the phosphate group from
both phospho-tyrosine and phospho-serine/threonine residues. Many of these
proteins have been related to the MAP kinase signalling pathway and hence they
are also termed MAP kinase phosphatases (MKPs). A group of DUSPs share a high
degree of similarity with the MKP subgroup, but lack the N-terminal regulatory
domain, which provides the substrate specificity towards the MAP kinases.
These proteins form a heterogeneous group and have in common the presence of
a single catalytic PTP domain. They are small-sized and have been named Low
Molecular Weight-DUSPs (LMW-DUSPs) or Atypical-DUSPs. VHR was the first
characterised member of this subfamily; its crystal structure is known [1,2].
 
The functions of many of the members of this group remain unknown, although 
some have been related to regulation of MAP kinase pathways [3-5]. VHR has
also been related to the control of cell-senescence [6]. On the basis of
sequence similarity, this family can be subdivided into two groups, for 
convenience termed A and B. 
 
ADSPHPHTASE is a 4-element fingerprint that provides a signature for the
atypical dual specificity phosphatase family. The fingerprint was derived from
an initial alignment of 16 sequences: the motifs were drawn from conserved
regions spanning the N-terminal portion of the alignment, avoiding the catalytic
PTP domain, which is conserved in the PTP superfamily. Four iterations on
SPTR49_32f were required to reach convergence, at which point a true set
comprising 47 sequences was identified. Several partial matches were also
found, representing orthologous DUSPs from different organisms.
Summary Information
  47 codes involving  4 elements
3 codes involving 3 elements
4 codes involving 2 elements
Composite Feature Index
447474747
31233
21331
1234
True Positives
DUS13_HUMAN   DUS13_MOUSE   DUS14_HUMAN   DUS14_MOUSE   
DUS18_BOVIN DUS18_HUMAN DUS18_MOUSE DUS18_PONPY
DUS18_RAT DUS21_HUMAN DUS3_HUMAN DUS3_MOUSE
DUS3_PONPY Q25DK0_MACFA Q25N50_MACFA Q29RA3_BRARE
Q32KN1_BOVIN Q3TLZ7_MOUSE Q497R2_MOUSE Q4R3T3_MACFA
Q4RQC9_TETNG Q4RQD0_TETNG Q4S3F5_TETNG Q4S3F6_TETNG
Q5FVI9_RAT Q5R6H6_PONPY Q5SV91_MOUSE Q5U0J1_HUMAN
Q5XIN2_RAT Q5XJN5_BRARE Q68J44_HUMAN Q6B8I0_MOUSE
Q6B8I1_HUMAN Q6FI36_HUMAN Q6GM01_XENLA Q6IAR0_HUMAN
Q7TNW3_MOUSE Q7TPY1_MOUSE Q8BK84_MOUSE Q8SXF8_DROME
Q96J67_HUMAN Q9BV47_HUMAN Q9D700_MOUSE Q9D9D8_MOUSE
Q9DA25_MOUSE Q9VWN2_DROME Q9Y346_HUMAN
True Positive Partials
Codes involving 3 elements
Q2T9T7_BOVIN Q5PQ70_XENLA Q8IYJ9_HUMAN
Codes involving 2 elements
Q3UQN8_MOUSE Q3V2Y9_MOUSE Q5VZP5_HUMAN Q7PNB0_ANOGA
Sequence Titles
DUS13_HUMAN Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal-muscle-specific DSP) (Dual specificity phosphatase SKRP4) - Homo sapiens (Human). 
DUS13_MOUSE Dual specificity protein phosphatase 13 (EC 3.1.3.48) (EC 3.1.3.16) (Testis- and skeletal muscle-specific DSP) (Dual specificity tyrosine phosphatase TS-DSP6) - Mus musculus (Mouse).
DUS14_HUMAN Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) (MKP-1-like protein tyrosine phosphatase) (MKP- L) - Homo sapiens (Human).
DUS14_MOUSE Dual specificity protein phosphatase 14 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) - Mus musculus (Mouse).
DUS18_BOVIN Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) - Bos taurus (Bovine).
DUS18_HUMAN Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 20) - Homo sapiens (Human).
DUS18_MOUSE Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) - Mus musculus (Mouse).
DUS18_PONPY Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) - Pongo pygmaeus (Orangutan).
DUS18_RAT Dual specificity protein phosphatase 18 (EC 3.1.3.48) (EC 3.1.3.16) - Rattus norvegicus (Rat).
DUS21_HUMAN Dual specificity protein phosphatase 21 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular weight dual specificity phosphatase 21) - Homo sapiens (Human).
DUS3_HUMAN Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR) - Homo sapiens (Human).
DUS3_MOUSE Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (T- DSP11) - Mus musculus (Mouse).
DUS3_PONPY Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) - Pongo pygmaeus (Orangutan).
Q25DK0_MACFA Brain cDNA clone: QtrA-16417, similar to human dual specificity phosphatase 14 (DUSP14), - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Q25N50_MACFA Brain cDNA clone: QorA-11778, similar to human hypothetical protein MGC1136 (MGC1136), - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Q29RA3_BRARE Hypothetical protein - Brachydanio rerio (Zebrafish) (Danio rerio).
Q32KN1_BOVIN Hypothetical protein DUSP18 - Bos taurus (Bovine).
Q3TLZ7_MOUSE Mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830020J01 product:dual specificity phosphatase 14, full insert sequence - Mus musculus (Mouse).
Q497R2_MOUSE Dusp13 protein - Mus musculus (Mouse).
Q4R3T3_MACFA Testis cDNA clone: QtsA-14359, similar to human dual specificity phosphatase 18 (DUSP18), - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
Q4RQC9_TETNG Chromosome 17 SCAF15006, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q4RQD0_TETNG Chromosome 17 SCAF15006, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q4S3F5_TETNG Chromosome 2 SCAF14750, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q4S3F6_TETNG Chromosome 2 SCAF14750, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q5FVI9_RAT Hypothetical protein RGD1310090 - Rattus norvegicus (Rat).
Q5R6H6_PONPY Hypothetical protein DKFZp468D1919 - Pongo pygmaeus (Orangutan).
Q5SV91_MOUSE Dual specificity phosphatase 14 (16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630043M20 product:dual specificity phosphatase 14, full insert sequence) (Blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0016E23 product:dual specificity phosphatase 14, full insert sequence) - Mus musculus (Mouse).
Q5U0J1_HUMAN Dual specificity phosphatase 3 (Vaccinia virus phosphatase VH1- related) - Homo sapiens (Human).
Q5XIN2_RAT Dual specificity phosphatase 13 - Rattus norvegicus (Rat).
Q5XJN5_BRARE Zgc:101746 - Brachydanio rerio (Zebrafish) (Danio rerio).
Q68J44_HUMAN FMDSP - Homo sapiens (Human).
Q6B8I0_MOUSE Muscle restricted dual specificity phosphatase - Mus musculus (Mouse).
Q6B8I1_HUMAN Muscle restricted dual specificity phosphatase - Homo sapiens (Human).
Q6FI36_HUMAN DUSP14 protein - Homo sapiens (Human).
Q6GM01_XENLA MGC84083 protein - Xenopus laevis (African clawed frog).
Q6IAR0_HUMAN DUSP13 protein - Homo sapiens (Human).
Q7TNW3_MOUSE Dsp13-like protein - Mus musculus (Mouse).
Q7TPY1_MOUSE Dusp14 protein - Mus musculus (Mouse).
Q8BK84_MOUSE 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110056B09 product:weakly similar to DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 (EC 3.1.3.48) (EC 3.1.3.16) (TESTIS- AND SKELETAL- MUSCLE-SPECIFIC DSP) (Similar to human protein phosphatase) - Mus musculus (Mouse).
Q8SXF8_DROME RH25447p - Drosophila melanogaster (Fruit fly).
Q96J67_HUMAN Branching-enzyme interacting dual-specificity protein phosphatase BEDP - Homo sapiens (Human).
Q9BV47_HUMAN Dual specificity phosphatase 26 (Low-molecular-mass dual-specificity phosphatase 4) (Dual-specificity phosphatase SKRP3) (Mitogen-activated protein kinase phosphatase 8) (NATA1 protein) (CDNA FLJ31142 fis, clone IMR322001317, weakly similar to Homo sapiens protein phosphatase) - Homo sapiens (Human).
Q9D700_MOUSE Adult male tongue cDNA, RIKEN full-length enriched library, clone:2310043K02 product:HYPOTHETICAL 23.9 kDa PROTEIN (CDNA FLJ31142 FIS, CLONE IMR322001317, WEAKLY SIMILAR TO HOMO SAPIENS PROTEIN PHOSPHATASE) homolog (Dusp26 protein) (Dual-specificity phosphatase SKRP3) - Mus musculus (Mouse).
Q9D9D8_MOUSE Adult male testis cDNA, RIKEN full-length enriched library, clone:1700094E07 product:hypothetical Dual specificity protein phosphatase containing protein, full insert sequence (Dual specificity phosphatase 21) - Mus musculus (Mouse).
Q9DA25_MOUSE Adult male testis cDNA, RIKEN full-length enriched library, clone:1700022L10 product:dual specificity phosphatase 13, full insert sequence - Mus musculus (Mouse).
Q9VWN2_DROME CG7378-PA - Drosophila melanogaster (Fruit fly).
Q9Y346_HUMAN Hypothetical protein (BJ-HCC-26 tumor antigen) - Homo sapiens (Human).

Q2T9T7_BOVIN Hypothetical protein - Bos taurus (Bovine).
Q5PQ70_XENLA LOC495963 protein - Xenopus laevis (African clawed frog).
Q8IYJ9_HUMAN DUSP3 protein - Homo sapiens (Human).

Q3UQN8_MOUSE 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330024O22 product:hypothetical Dual specificity protein phosphatase containing protein, full insert sequence - Mus musculus (Mouse).
Q3V2Y9_MOUSE 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630035G15 product:dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related), full insert sequence - Mus musculus (Mouse).
Q5VZP5_HUMAN Novel protein - Homo sapiens (Human).
Q7PNB0_ANOGA ENSANGP00000021958 - Anopheles gambiae str. PEST.
Scan History
SPTR49_32f 4  190  NSINGLE    
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
WPNLFIGDAATAN Q96J67_HUMAN 42 42 -
WPSLFLGDAYAAR DUS13_HUMAN 50 50 -
TSSLFLGRASVAS DUS14_MOUSE 31 31 -
WPNLFLGDAYAAR Q5XIN2_RAT 50 50 -
TSSLFLGRGSVAS DUS14_HUMAN 31 31 -
TSSLFLGRASVAS Q7TPY1_MOUSE 31 31 -
TKSLYISNGVAAN DUS18_PONPY 24 24 -
WPKLYIGDEATAL Q68J44_HUMAN 59 59 -
TPRIYVGNASVAQ DUS3_HUMAN 34 34 -
TPRIYVGNASVAQ DUS3_PONPY 34 34 -
TKSLFISNGAAAN DUS18_RAT 24 24 -
TKSLYISNGVAAN DUS18_HUMAN 24 24 -
TKSLFISNGVAAN DUS18_MOUSE 24 24 -
TSSLYISSGVAAN DUS18_BOVIN 24 24 -
VPRVYVGNASVAQ DUS3_MOUSE 34 34 -
TRSLFLSNGVAAN DUS21_HUMAN 26 26 -

Motif 2 width=12
Element Seqn Id St Int Rpt
LWKLGITHVLNA Q96J67_HUMAN 59 4 -
LIQLGITHVVNA DUS13_HUMAN 67 4 -
LQARGITCVINA DUS14_MOUSE 48 4 -
LIQLGITHVVNV Q5XIN2_RAT 67 4 -
LQARGITCIVNA DUS14_HUMAN 48 4 -
LQARGITCDINA Q7TPY1_MOUSE 48 4 -
LSSNQITMVINV DUS18_PONPY 41 4 -
LQKAGFTHVLNA Q68J44_HUMAN 76 4 -
LQKLGITHVLNA DUS3_HUMAN 51 4 -
LQKLGITHVLNA DUS3_PONPY 51 4 -
LSSNQITTVINV DUS18_RAT 41 4 -
LSSNQITMVINV DUS18_HUMAN 41 4 -
LSSNQITTVINV DUS18_MOUSE 41 4 -
LSSNRISTVINV DUS18_BOVIN 41 4 -
LQKLGITHVLNA DUS3_MOUSE 51 4 -
LSSNRITAIVNA DUS21_HUMAN 43 4 -

Motif 3 width=10
Element Seqn Id St Int Rpt
YLGVPAHDLP Q96J67_HUMAN 90 19 -
YYGIEADDNP DUS13_HUMAN 99 20 -
YVKVPLADIP DUS14_MOUSE 73 13 -
YYGIEADDNP Q5XIN2_RAT 99 20 -
YVKVPLADMP DUS14_HUMAN 73 13 -
YVKVPLADIP Q7TPY1_MOUSE 73 13 -
YLQVPVADAP DUS18_PONPY 66 13 -
YHGVEADDLP Q68J44_HUMAN 108 20 -
YLGIKANDTQ DUS3_HUMAN 85 22 -
YLGIKANDTQ DUS3_PONPY 85 22 -
YVQVPVVDAP DUS18_RAT 66 13 -
YMQVPVADSP DUS18_HUMAN 66 13 -
YVQVPVVDAP DUS18_MOUSE 66 13 -
YVQVPVADTP DUS18_BOVIN 66 13 -
YLGIKANDTQ DUS3_MOUSE 85 22 -
YIKVPVTDAR DUS21_HUMAN 68 13 -

Motif 4 width=12
Element Seqn Id St Int Rpt
YFSSAADFIHRA Q96J67_HUMAN 106 6 -
YFLPVARYIRAA DUS13_HUMAN 115 6 -
YFDTVADKIHSV DUS14_MOUSE 89 6 -
YFLPVARYIRDA Q5XIN2_RAT 115 6 -
YFDTVADKIHSV DUS14_HUMAN 89 6 -
YFDTVADKIHSV Q7TPY1_MOUSE 89 6 -
FFDPVADHIHSV DUS18_PONPY 82 6 -
FFYPAAAFIDRA Q68J44_HUMAN 124 6 -
YFERAADFIDQA DUS3_HUMAN 101 6 -
YFERAADFIDQA DUS3_PONPY 101 6 -
FFDPIADHIHSV DUS18_RAT 82 6 -
FFDPIADHIHSV DUS18_HUMAN 82 6 -
FFDSVADRIHSV DUS18_MOUSE 82 6 -
FFDPIADHIHSV DUS18_BOVIN 82 6 -
YFERATDFIDQA DUS3_MOUSE 101 6 -
FFDPIADLIHTI DUS21_HUMAN 84 6 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
WPNLFIGDAATAN Q6B8I1_HUMAN 42 42 -
WPNLFIGDAATAN Q96J67_HUMAN 42 42 -
WPNLFIGDAATAN Q6B8I0_MOUSE 42 42 -
WPGLYLGDQDMAN Q5FVI9_RAT 66 66 -
WPGLYLGDQDMAN Q9D700_MOUSE 66 66 -
WPGLYLGDQDMAN Q9BV47_HUMAN 66 66 -
WPGLYLGDQDMAN Q5R6H6_PONPY 66 66 -
WPSLFLGDAYAAR DUS13_HUMAN 50 50 -
WPSLFLGDAYAAR Q6IAR0_HUMAN 50 50 -
TSSLFLGRASVAS DUS14_MOUSE 31 31 -
TSSLFLGRASVAS Q5SV91_MOUSE 31 31 -
TSSLFLGRASVAS Q3TLZ7_MOUSE 31 31 -
TPSLFLGRGNVAS Q5XJN5_BRARE 54 54 -
WPNLFLGDMSVAN Q4S3F6_TETNG 39 39 -
WPNLFLGDAYAAR Q5XIN2_RAT 50 50 -
WPGLYLGDQDMAS Q25N50_MACFA 66 66 -
TSSLFLGRGSVAS DUS14_HUMAN 31 31 -
TSSLFLGRGSVAS Q6FI36_HUMAN 31 31 -
TSSLFLGRGSVAS Q25DK0_MACFA 31 31 -
TSSLFLGRASVAS Q7TPY1_MOUSE 31 31 -
WPNLFLGDAYAAR DUS13_MOUSE 50 50 -
WPNLFLGDAYAAR Q9DA25_MOUSE 115 115 -
WPNLFLGDAYAAR Q7TNW3_MOUSE 115 115 -
WPNLFLGDAYAAR Q497R2_MOUSE 50 50 -
WPKIYIGNAAVAH Q4S3F5_TETNG 36 36 -
WPNLYIGNVAVAQ Q4RQD0_TETNG 34 34 -
TKSLYISNGVAAN DUS18_PONPY 24 24 -
WPRLYLGDMFMSH Q4RQC9_TETNG 75 75 -
WPKLYIGDEATAL Q68J44_HUMAN 59 59 -
TPRIYVGNASVAQ DUS3_HUMAN 34 34 -
TPRIYVGNASVAQ Q5U0J1_HUMAN 34 34 -
TPRIYVGNASVAQ DUS3_PONPY 34 34 -
TKSLFISNGAAAN DUS18_RAT 24 24 -
TKSLYISNGVAAN DUS18_HUMAN 24 24 -
TKSLYISNGVAAN Q4R3T3_MACFA 24 24 -
TKSLFISNGVAAN DUS18_MOUSE 24 24 -
WPRLHIGDEATAL Q8BK84_MOUSE 58 58 -
TSSLYISRGVAAN Q32KN1_BOVIN 24 24 -
TSSLYISSGVAAN DUS18_BOVIN 24 24 -
VPRVYVGNASVAQ DUS3_MOUSE 34 34 -
YPGIYIGDAAAAK Q8SXF8_DROME 55 55 -
YPGIYIGDAAAAK Q9VWN2_DROME 55 55 -
WPGVYIGNEETAR Q29RA3_BRARE 38 38 -
TASLFISNSAVAN Q9D9D8_MOUSE 25 25 -
TRSLFLSNGVAAN DUS21_HUMAN 26 26 -
TRSLFLSNGVAAN Q9Y346_HUMAN 26 26 -
SPCLYLSSGNAAG Q6GM01_XENLA 41 41 -

Motif 2 width=12
Element Seqn Id St Int Rpt
LWKLGITHVLNA Q6B8I1_HUMAN 59 4 -
LWKLGITHVLNA Q96J67_HUMAN 59 4 -
LWKLGITHVLNA Q6B8I0_MOUSE 59 4 -
LRRLGITHVLNA Q5FVI9_RAT 83 4 -
LRRLGITHVLNA Q9D700_MOUSE 83 4 -
LRRLGITHVLNA Q9BV47_HUMAN 83 4 -
LRRLGITHVLNA Q5R6H6_PONPY 83 4 -
LIQLGITHVVNA DUS13_HUMAN 67 4 -
LIQLGITHVVNA Q6IAR0_HUMAN 67 4 -
LQARGITCVINA DUS14_MOUSE 48 4 -
LQARGITCVINA Q5SV91_MOUSE 48 4 -
LQARGITCVINA Q3TLZ7_MOUSE 48 4 -
LLSKGITCVVNA Q5XJN5_BRARE 71 4 -
LWKLGISHVVNA Q4S3F6_TETNG 56 4 -
LIQLGITHVVNV Q5XIN2_RAT 67 4 -
LRRLGITHVLNA Q25N50_MACFA 83 4 -
LQARGITCIVNA DUS14_HUMAN 48 4 -
LQARGITCIVNA Q6FI36_HUMAN 48 4 -
LQARGITCIVNA Q25DK0_MACFA 48 4 -
LQARGITCDINA Q7TPY1_MOUSE 48 4 -
LIQLGITHVVNV DUS13_MOUSE 67 4 -
LIQLGITHVVNV Q9DA25_MOUSE 132 4 -
LIQLGITHVVNV Q7TNW3_MOUSE 132 4 -
LIQLGITHVVNV Q497R2_MOUSE 67 4 -
LRKLGITHVLNA Q4S3F5_TETNG 53 4 -
LHKLGITHVLNA Q4RQD0_TETNG 51 4 -
LSSNQITMVINV DUS18_PONPY 41 4 -
LWQLGVTHVLNA Q4RQC9_TETNG 92 4 -
LQKAGFTHVLNA Q68J44_HUMAN 76 4 -
LQKLGITHVLNA DUS3_HUMAN 51 4 -
LQKLGITHVLNA Q5U0J1_HUMAN 51 4 -
LQKLGITHVLNA DUS3_PONPY 51 4 -
LSSNQITTVINV DUS18_RAT 41 4 -
LSSNQITMVINV DUS18_HUMAN 41 4 -
LSSNQITMVINV Q4R3T3_MACFA 41 4 -
LSSNQITTVINV DUS18_MOUSE 41 4 -
LQKAGFTHVLNA Q8BK84_MOUSE 75 4 -
LSSNRISTVINV Q32KN1_BOVIN 41 4 -
LSSNRISTVINV DUS18_BOVIN 41 4 -
LQKLGITHVLNA DUS3_MOUSE 51 4 -
LRLMGITHVLNA Q8SXF8_DROME 72 4 -
LRLMGITHVLNA Q9VWN2_DROME 72 4 -
LQTLGITHILNA Q29RA3_BRARE 55 4 -
LSNNHITTIINV Q9D9D8_MOUSE 42 4 -
LSSNRITAIVNA DUS21_HUMAN 43 4 -
LSSNRITAIVNA Q9Y346_HUMAN 43 4 -
LYSRNVTCIVNA Q6GM01_XENLA 58 4 -

Motif 3 width=10
Element Seqn Id St Int Rpt
YLGVPAHDLP Q6B8I1_HUMAN 90 19 -
YLGVPAHDLP Q96J67_HUMAN 90 19 -
YLGIPAHDLP Q6B8I0_MOUSE 90 19 -
YLGVEAHDSP Q5FVI9_RAT 113 18 -
YLGVEAHDSP Q9D700_MOUSE 113 18 -
YLGVEAHDSP Q9BV47_HUMAN 113 18 -
YLGVEAHDSP Q5R6H6_PONPY 113 18 -
YYGIEADDNP DUS13_HUMAN 99 20 -
YYGIEADDNP Q6IAR0_HUMAN 99 20 -
YVKVPLADIP DUS14_MOUSE 73 13 -
YVKVPLADIP Q5SV91_MOUSE 73 13 -
YVKVPLADIP Q3TLZ7_MOUSE 73 13 -
YVKVPLADMP Q5XJN5_BRARE 96 13 -
YYGVPAEDSP Q4S3F6_TETNG 87 19 -
YYGIEADDNP Q5XIN2_RAT 99 20 -
SLGVEAHDSP Q25N50_MACFA 113 18 -
YVKVPLADMP DUS14_HUMAN 73 13 -
YVKVPLADMP Q6FI36_HUMAN 73 13 -
YVKVPLADMP Q25DK0_MACFA 73 13 -
YVKVPLADIP Q7TPY1_MOUSE 73 13 -
YYGIEADDNP DUS13_MOUSE 99 20 -
YYGIEADDNP Q9DA25_MOUSE 164 20 -
YYGIEADDNP Q7TNW3_MOUSE 164 20 -
YYGIEADDNP Q497R2_MOUSE 99 20 -
YCGIPADDST Q4S3F5_TETNG 84 19 -
YLGIPAEDSE Q4RQD0_TETNG 82 19 -
YLQVPVADAP DUS18_PONPY 66 13 -
YYGVPANDLP Q4RQC9_TETNG 123 19 -
YHGVEADDLP Q68J44_HUMAN 108 20 -
YLGIKANDTQ DUS3_HUMAN 85 22 -
YLGIKANDTQ Q5U0J1_HUMAN 85 22 -
YLGIKANDTQ DUS3_PONPY 85 22 -
YVQVPVVDAP DUS18_RAT 66 13 -
YMQVPVADSP DUS18_HUMAN 66 13 -
YMQVPVADAP Q4R3T3_MACFA 66 13 -
YVQVPVVDAP DUS18_MOUSE 66 13 -
YHGVEADDVP Q8BK84_MOUSE 107 20 -
YVQVPVADTP Q32KN1_BOVIN 66 13 -
YVQVPVADTP DUS18_BOVIN 66 13 -
YLGIKANDTQ DUS3_MOUSE 85 22 -
YMGFPMVDAP Q8SXF8_DROME 107 23 -
YMGFPMVDAP Q9VWN2_DROME 107 23 -
YYGVTAEDTP Q29RA3_BRARE 88 21 -
YVQVPVSDAP Q9D9D8_MOUSE 67 13 -
YIKVPVTDAR DUS21_HUMAN 68 13 -
YIKVPVTDAR Q9Y346_HUMAN 68 13 -
YMKVPVPDLP Q6GM01_XENLA 83 13 -

Motif 4 width=12
Element Seqn Id St Int Rpt
YFSSAADFIHRA Q6B8I1_HUMAN 106 6 -
YFSSAADFIHRA Q96J67_HUMAN 106 6 -
YFSSAADFIHRA Q6B8I0_MOUSE 106 6 -
HFQTAADFIHRA Q5FVI9_RAT 129 6 -
HFQTAADFIHRA Q9D700_MOUSE 129 6 -
HFQTAADFIHRA Q9BV47_HUMAN 129 6 -
HFQTAADFIHRA Q5R6H6_PONPY 129 6 -
YFLPVARYIRAA DUS13_HUMAN 115 6 -
YFLPVARYIRAA Q6IAR0_HUMAN 115 6 -
YFDTVADKIHSV DUS14_MOUSE 89 6 -
YFDTVADKIHSV Q5SV91_MOUSE 89 6 -
YFDTVADKIHSV Q3TLZ7_MOUSE 89 6 -
YFDSVADKIHSV Q5XJN5_BRARE 112 6 -
YFFPSADYIKKA Q4S3F6_TETNG 103 6 -
YFLPVARYIRDA Q5XIN2_RAT 115 6 -
HFQTAADFIHRA Q25N50_MACFA 129 6 -
YFDTVADKIHSV DUS14_HUMAN 89 6 -
YFDTVADKIHSV Q6FI36_HUMAN 89 6 -
YFDTVADKIHSV Q25DK0_MACFA 89 6 -
YFDTVADKIHSV Q7TPY1_MOUSE 89 6 -
HFLPVARYIRDA DUS13_MOUSE 115 6 -
HFLPVARYIRDA Q9DA25_MOUSE 180 6 -
HFLPVARYIRDA Q7TNW3_MOUSE 180 6 -
HFLPVARYIRDA Q497R2_MOUSE 115 6 -
YFQPAADFIHKA Q4S3F5_TETNG 100 6 -
YFRVAVDFIHRV Q4RQD0_TETNG 98 6 -
FFDPVADHIHSV DUS18_PONPY 82 6 -
FFYPAAEFIHQA Q4RQC9_TETNG 139 6 -
FFYPAAAFIDRA Q68J44_HUMAN 124 6 -
YFERAADFIDQA DUS3_HUMAN 101 6 -
YFERAADFIDQA Q5U0J1_HUMAN 101 6 -
YFERAADFIDQA DUS3_PONPY 101 6 -
FFDPIADHIHSV DUS18_RAT 82 6 -
FFDPIADHIHSV DUS18_HUMAN 82 6 -
FFDPIADHIHSV Q4R3T3_MACFA 82 6 -
FFDSVADRIHSV DUS18_MOUSE 82 6 -
FFYSAAAFIDSA Q8BK84_MOUSE 123 6 -
FFDPIADHIHSV Q32KN1_BOVIN 82 6 -
FFDPIADHIHSV DUS18_BOVIN 82 6 -
YFERATDFIDQA DUS3_MOUSE 101 6 -
YFYVASKFIDSA Q8SXF8_DROME 123 6 -
YFYVASKFIDSA Q9VWN2_DROME 123 6 -
YFYSAAEYIQQT Q29RA3_BRARE 104 6 -
FFDPIADHIHGV Q9D9D8_MOUSE 83 6 -
FFDPIADLIHTI DUS21_HUMAN 84 6 -
FFDPIADLIHTI Q9Y346_HUMAN 84 6 -
YFDSVADRIHQN Q6GM01_XENLA 99 6 -