SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR01868

Identifier
ABCEFAMILY  [View Relations]  [View Alignment]  
Accession
PR01868
No. of Motifs
6
Creation Date
13-MAR-2003
Title
ABC transporter family E signature
Database References
Literature References
1. BISBAL, C., MARTINAND, C., SILHOL, M., LEBLEU, B. AND SALEHZADA, T.
Cloning and characterization of an RNase L inhibitor: a new component of the
interferon-regulated 2-5A pathway.
J.BIOL.CHEM. 270 13308-13317 (1995).
 
2. DEAN, M., RZHETSKY, A. AND ALLIKMETS, R.
The human ATP-binding cassette (ABC) transporter superfamily.
GENOME RESEARCH 11 1156-1166 (2001).
 
3. ZIMMERMAN, C., KLEIN, K.C., KISER, P.K., SINGH, A.R., FIRESTEIN, B.L.,
RIBA, S.C. AND LINGAPPA, J.R.
Identification of a host protein essential for assembly of immature HIV-1
capsids.
NATURE 415 88-92 (2002).
 
4. BENOIT DE COIGNAC, A., BISPAL, C., LEBLEU, B. AND SALHZADA, T. 
cDNA cloning and expression analysis of the murine ribonuclease L
inhibitor.
GENE 209 149-156 (1998).
 
5. MARTINAND, C., MONTAVON, C., SALEHZADA, T., SILHOL, M., LEBLEU, B. AND
BISPAL, C.
RNase L inhibitor is induced during human immunodeficiency virus type I
infection and down regulates the 2-5A/RNase L pathway in human cels.
J.VIROL. 73 290-296 (1999).

Documentation
The ABCE family of ATP-binding cassette (ABC) transporters solely comprises
the ABCE1 gene product, a 68kDa polypeptide found in insect cells and multi-
cellular eukaryotes, but not in yeast [1-3]. Originally described by Bisbal 
et al. [1], ABCE1 contains 2 nucleotide-binding domains (NBDs) typical of 
the ABC transporter protein superfamily; however, it lacks transmembrane 
domains required for membrane transport functions [1,2].
 
ABCE1 is an endoribonuclease inhibitor that interacts directly with RNase L
to prevent it from binding 2-5A (5'-phosphorylated 2',5'-linked oligo-
adenylates) [1]. RNase L plays a major role in the anti-viral and anti-
proliferative activities of interferons, and its inhibition by ABCE1
occurs in a concentration-dependent manner [1,4].
 
Recently, ABCE1 has been shown to be essential for the assembly of immature
HIV-1 capsids in insect cells and higher eukaryotic cell types [3]. ABCE1 
expression is induced during HIV type I infection, and is understood to
bind HIV-1 Gag (p55) polypeptides following their translation, and to
promote their assembly into immature HIV-1 capsids [1,3,5].
 
ABCEFAMILY is a 6-element fingerprint that provides a signature for the E
subfamily of ABC transporters. The fingerprint was derived from an initial
alignment of 10 sequences: all motifs were drawn from the first third of the
alignment, focusing on those regions that distinguish ABCE1 polypeptides
from other members of the ABC transporter superfamily - motif 1 resides in
the putative metal-binding domain; motif 2 lies in the 4Fe-4S iron-sulphur-
binding domain; motif 3 lies between the 4Fe-4S domain and the NBD; motif 4
lies in the ATP-binding region of the NBD; and motifs 5 and 6 reside in the
C-terminal NBD. Two iterations on SPTR40_20f were required to reach 
convergence, at which point a true set comprising 25 sequences was 
identified. A single partial match was also found, a hypothetical protein 
that may be a truncated ABCE1.
Summary Information
  25 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
6252525252525
5000000
4000000
3000000
2011000
123456
True Positives
O27730        O30231        O49679        O58589        
O60102 O88793 Q03195 Q13181
Q8ZVC5 Q93YY0 Q96B10 Q975V6
Q977Z2 Q980K5 Q98SB3 Q99K66
Q9GRP4 Q9HI55 Q9HMC1 Q9LID6
Q9U2K8 Q9UZA4 Q9VSS1 Q9YCZ3
Y719_METJA
True Positive Partials
Codes involving 2 elements
O49678
Sequence Titles
O27730      RNASE L INHIBITOR - Methanothermobacter thermautotrophicus. 
O30231 RNASE L INHIBITOR - Archaeoglobus fulgidus.
O49679 RNASE L INHIBITOR (RNASE L INHIBITOR-LIKE PROTEIN) - Arabidopsis thaliana (Mouse-ear cress).
O58589 590AA LONG HYPOTHETICAL TRANSPORT PROTEIN - Pyrococcus horikoshii.
O60102 PUTATIVE RNASE L INHIBITOR - Schizosaccharomyces pombe (Fission yeast).
O88793 RNASE L INHIBITOR - Mus musculus (Mouse).
Q03195 HYPOTHETICAL 68.3 KDA PROTEIN - Saccharomyces cerevisiae (Baker's yeast).
Q13181 RNASE L INHIBITOR - Homo sapiens (Human).
Q8ZVC5 RNASE L INHIBITOR HOMOLOG - Pyrobaculum aerophilum.
Q93YY0 68 KDA PROTEIN HP68 - Triticum aestivum (Wheat).
Q96B10 ATP-BINDING CASSETTE, SUB-FAMILY E (OABP), MEMBER 1 - Homo sapiens (Human).
Q975V6 PUTATIVE RNASE L INHIBITOR - Sulfolobus tokodaii.
Q977Z2 RNASE L INHIBITOR - Thermoplasma volcanium.
Q980K5 RNASE L INHIBITOR - Sulfolobus solfataricus.
Q98SB3 RNASE L INHIBITOR - Guillardia theta (Cryptomonas phi).
Q99K66 ATP-BINDING CASSETTE, SUB-FAMILY E (OABP), MEMBER 1 - Mus musculus (Mouse).
Q9GRP4 BACTERIAL-TYPE ABC TRANSPORT ATP-BINDING SUBUNIT? OR RNASE L INHIBITOR - Leishmania major.
Q9HI55 PROBABLE RNASE L INHIBITOR - Thermoplasma acidophilum.
Q9HMC1 RNASE L INHIBITOR HOMOLOG - Halobacterium sp. (strain NRC-1).
Q9LID6 RNASE L INHIBITOR - Arabidopsis thaliana (Mouse-ear cress).
Q9U2K8 Y39E4B.1 PROTEIN - Caenorhabditis elegans.
Q9UZA4 RNASE L INHIBITOR - Pyrococcus abyssi.
Q9VSS1 CG5651 PROTEIN - Drosophila melanogaster (Fruit fly).
Q9YCZ3 604AA LONG HYPOTHETICAL RNASE L INHIBITOR - Aeropyrum pernix.
Y719_METJA Hypothetical ABC transporter ATP-binding protein MJ0719 - Methanococcus jannaschii.

O49678 HYPOTHETICAL 29.1 KDA PROTEIN - Arabidopsis thaliana (Mouse-ear cress).
Scan History
SPTR40_20f 2  50   NSINGLE    
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
ECKKSCPVVRMGKLCI Q96B10 24 24 -
ECKKSCPVVKTGKLCI Q93YY0 24 24 -
ECKKTCPVVRMGKLCI Q9VSS1 32 32 -
ECRRSCPVVRTGKLCI O60102 24 24 -
ECYKCCPVVLQGKLCI Q9GRP4 32 32 -
LCERVCPVNRMGGEAI Q9UZA4 24 24 -
ECINFCPVDRSGGKAI Q980K5 19 19 -
ECVKYCPVNKSGKVVW Q8ZVC5 20 20 -
ECQYYCPPVRNHVMAI Q977Z2 22 22 -
ECKKNCPVEKAGKLCI Q98SB3 29 29 -

Motif 2 width=25
Element Seqn Id St Int Rpt
ETLCIGCGICIKKCPFGALSIVNLP Q96B10 52 12 -
EELCIGCGICVKKCPFDAIEIINLP Q93YY0 52 12 -
EELCIGCGICVKKCPFEAITIINLP Q9VSS1 60 12 -
ETLCIGCGICVKKCPFGAINIINLP O60102 52 12 -
EELCIGCALCVKKCPYDAIRIINLP Q9GRP4 60 12 -
EASCTGCGICVHKCPFNAISIVNLP Q9UZA4 52 12 -
EETCIGCGICVKKCPYEAISIVNLP Q980K5 48 13 -
EALCIGCGICVHKCPFEAITIVNLP Q8ZVC5 47 11 -
ETLCIGCGICIRRCPFGAIRIVTLP Q977Z2 50 12 -
EINCIGCGICVKKCPYDAIKIINLP Q98SB3 57 12 -

Motif 3 width=21
Element Seqn Id St Int Rpt
LEKETTHRYCANAFKLHRLPI Q96B10 79 2 -
LEKDTTHRYGPNTFKLHRLPV Q93YY0 79 2 -
LEKHTTHRYSKNSFKLHRLPI Q9VSS1 87 2 -
LESEVTHRYSANSFKLHRLPT O60102 79 2 -
LERDTVHRYGPNSFKLHRLPL Q9GRP4 87 2 -
LDEDCVHRYGVNAFVLYRLPI Q9UZA4 79 2 -
LEGEVIHRYKVNGFKLFGLPT Q980K5 75 2 -
LERDCVHRYGPSGFKLYRLPI Q8ZVC5 74 2 -
LNKNVFHRYGVNGFRIYSLPT Q977Z2 77 2 -
MKKKPIHSFGLNSFRLYSLPI Q98SB3 83 1 -

Motif 4 width=26
Element Seqn Id St Int Rpt
GLVGTNGIGKSTALKILAGKQKPNLG Q96B10 107 7 -
GLVGTNGIGKSTALKVLAGKLKPNLG Q93YY0 107 7 -
GLVGQNGIGKSTALKILAGKQKPNLG Q9VSS1 115 7 -
GLVGTNGIGKSTALKILSGKMKPNLG O60102 107 7 -
GLVGANGTGKSTALSVLKGRIRPNLG Q9GRP4 115 7 -
GIVGPNGTGKTTAVKILAGQLIPNLC Q9UZA4 107 7 -
GVLGKNGVGKTTVLKILAGEIIPNFG Q980K5 103 7 -
GILGRNALGKTTMAKILAGELVPNLC Q8ZVC5 102 7 -
AILGQNGLGKTTTLNILSGITVPNLG Q977Z2 105 7 -
GLIGANGIGKSTSFKIIAGELYPNFG Q98SB3 111 7 -

Motif 5 width=17
Element Seqn Id St Int Rpt
WQEILTYFRGSELQNYF Q96B10 140 7 -
WQEILTYFRGSELQNYF Q93YY0 140 7 -
WTEILSYFRGSELQNYF Q9VSS1 148 7 -
WAEVVKYFRGSELQNFF O60102 140 7 -
WDEILKYFRGSEHQAYF Q9GRP4 148 7 -
WDNVIRAFRGNELQNYF Q9UZA4 138 5 -
KDEVLKRFRGKEIYNYF Q980K5 136 7 -
AEDVIRQFRGTELQTYF Q8ZVC5 135 7 -
KDAVIDRFARTTMGAYF Q977Z2 138 7 -
YKETVKLFKGSELFYFF Q98SB3 144 7 -

Motif 6 width=27
Element Seqn Id St Int Rpt
FTKILEDDLKAIIKPQYVDQIPKAAKG Q96B10 156 -1 -
FTRILEDNLKAIIKPQYVDHIPKAVQG Q93YY0 156 -1 -
FTKILEDNLKALVKPQYVDQIPKAVRG Q9VSS1 164 -1 -
FTKVVEDNIKALIKPQYVDHIPRAIKT O60102 156 -1 -
FQHLLDDKMRVLLKPQYVDKVPKTNNG Q9GRP4 164 -1 -
FERLKNGEIRPVVKPQYVDLLPKAVKG Q9UZA4 154 -1 -
FKELYSNELKIVHKIQYVEYASKFLKG Q980K5 152 -1 -
FSELYSNKLRAVHKIQYIELIPIYLKG Q8ZVC5 151 -1 -
FKGLYEENKRAVLKNQYVDYIPKVVSG Q977Z2 154 -1 -
FQEFEKKKITVSIKTQNVEKLRETFNG Q98SB3 160 -1 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
ECKKSCPVVRMGKLCI Q96B10 24 24 -
ECKKSCPVVRMGKLCI Q99K66 24 24 -
ECKKSCPVVKTGKLCI O49679 24 24 -
ECKKSCPVVRMGKLCI O88793 24 24 -
ECKKSCPVVKTGKLCI Q93YY0 24 24 -
ECKKTCPVVRMGKLCI Q9VSS1 32 32 -
ECKRSCPVVKTGKLCI Q03195 24 24 -
ECKKSCPVVRMGKLCI Q13181 24 24 -
ECKKSCPVVKTGKLCI Q9LID6 24 24 -
ECRRSCPVVRTGKLCI O60102 24 24 -
ACKRACPVNRQGKQCI Q9U2K8 35 35 -
ECYKCCPVVLQGKLCI Q9GRP4 32 32 -
LCERVCPVNRMGGEAI O58589 20 20 -
LCERVCPVNRMGGEAI Q9UZA4 24 24 -
ECMKYCPGVRMGEKTI Y719_METJA 31 31 -
ECINFCPVDRSGGKAI Q980K5 19 19 -
ECVKYCPVNKSGKVVW Q8ZVC5 20 20 -
VCIEYCPGVRMDEDTI O27730 52 52 -
ECVKYCPRVRTGDETV O30231 21 21 -
ECSNYCPPNRTGKECI Q9HMC1 22 22 -
ECIAVCPVNKSGRGVA Q9YCZ3 15 15 -
ECQYYCPPVRNHVMAI Q9HI55 19 19 -
ECITFCPINRSGSKAI Q975V6 19 19 -
ECQYYCPPVRNHVMAI Q977Z2 22 22 -
ECKKNCPVEKAGKLCI Q98SB3 29 29 -

Motif 2 width=25
Element Seqn Id St Int Rpt
ETLCIGCGICIKKCPFGALSIVNLP Q96B10 52 12 -
ETLCIGCGICIKKCPFGALSIVNLP Q99K66 52 12 -
EELCIGCGICVKKCPFEAIQIINLP O49679 52 12 -
ETLCIGCGICIKKCPFGALSIVNLP O88793 52 12 -
EELCIGCGICVKKCPFDAIEIINLP Q93YY0 52 12 -
EELCIGCGICVKKCPFEAITIINLP Q9VSS1 60 12 -
EILCIGCGICVKKCPFDAIQIINLP Q03195 52 12 -
ETLCIGCGICIKKCPFGALSIVNLP Q13181 52 12 -
EELCIGCGICVKKCPFEAIQIINLP Q9LID6 52 12 -
ETLCIGCGICVKKCPFGAINIINLP O60102 52 12 -
EILCIGCGICVKKCPYDAIKIINLP Q9U2K8 63 12 -
EELCIGCALCVKKCPYDAIRIINLP Q9GRP4 60 12 -
EASCTGCGICVHKCPFKAISIVNLP O58589 48 12 -
EASCTGCGICVHKCPFNAISIVNLP Q9UZA4 52 12 -
EVLCSGCGICVKRCPFKAISIIGLP Y719_METJA 59 12 -
EETCIGCGICVKKCPYEAISIVNLP Q980K5 48 13 -
EALCIGCGICVHKCPFEAITIVNLP Q8ZVC5 47 11 -
EELCSGCGICTKRCPFKAISVINLP O27730 80 12 -
ENLCVGCGICVKKCPMHAIWIVGLP O30231 46 9 -
ICLGESCGICVEKCPFDAIEIINLP Q9HMC1 58 20 -
EDACIGCALCVKACPFDAIYIVNLP Q9YCZ3 45 14 -
ETLCIGCGICIRRCPFGAIKIVTLP Q9HI55 47 12 -
EETCIGCGICIKKCPFEAIDIVNLP Q975V6 48 13 -
ETLCIGCGICIRRCPFGAIRIVTLP Q977Z2 50 12 -
EINCIGCGICVKKCPYDAIKIINLP Q98SB3 57 12 -

Motif 3 width=21
Element Seqn Id St Int Rpt
LEKETTHRYCANAFKLHRLPI Q96B10 79 2 -
LEKETTHRYCANAFKLHRLPI Q99K66 79 2 -
LEKDTTHRYGANTFKLHRLPV O49679 79 2 -
LEKETTHRYCANAFKLHRLPI O88793 79 2 -
LEKDTTHRYGPNTFKLHRLPV Q93YY0 79 2 -
LEKHTTHRYSKNSFKLHRLPI Q9VSS1 87 2 -
LEAHVTHRYSANSFKLHRLPT Q03195 79 2 -
LEKETTHRYCANAFKLHRLPI Q13181 79 2 -
LAKDTTHRYGANGFKLHRLPI Q9LID6 79 2 -
LESEVTHRYSANSFKLHRLPT O60102 79 2 -
LANETTHRYSQNSFKLHRLPT Q9U2K8 90 2 -
LERDTVHRYGPNSFKLHRLPL Q9GRP4 87 2 -
LEEDCVHRYGVNAFVLYRLPV O58589 75 2 -
LDEDCVHRYGVNAFVLYRLPI Q9UZA4 79 2 -
SEDKIVHSYGQNRFKLFGLVI Y719_METJA 87 3 -
LEGEVIHRYKVNGFKLFGLPT Q980K5 75 2 -
LERDCVHRYGPSGFKLYRLPI Q8ZVC5 74 2 -
ALENPVHRYGQNQFELFGIPA O27730 106 1 -
LEGREVHRYGKNGFVLYNLPV O30231 73 2 -
LDDQPTHRYGENSFSLYGLPV Q9HMC1 85 2 -
LEEEAVHRYGVNGFKLFRLPI Q9YCZ3 72 2 -
LNKEVLHRYGVNGFRIYSIPT Q9HI55 74 2 -
YGEDVIHRYKINGFKLFGIVT Q975V6 75 2 -
LNKNVFHRYGVNGFRIYSLPT Q977Z2 77 2 -
MKKKPIHSFGLNSFRLYSLPI Q98SB3 83 1 -

Motif 4 width=26
Element Seqn Id St Int Rpt
GLVGTNGIGKSTALKILAGKQKPNLG Q96B10 107 7 -
GLVGTNGIGKSTALKILAGKQKPNLG Q99K66 107 7 -
GLVGTNGIGKSTALKILAGKLKPNLG O49679 107 7 -
GLVGTNGIGKSTALKILAGKQKPNLG O88793 107 7 -
GLVGTNGIGKSTALKVLAGKLKPNLG Q93YY0 107 7 -
GLVGQNGIGKSTALKILAGKQKPNLG Q9VSS1 115 7 -
GLVGTNGIGKSTALKILAGKQKPNLG Q03195 107 7 -
GLVGTNGIGKSAALKILAGKQKPNLG Q13181 107 7 -
GLVGTNGIGKSTALKILAGKLKPNLG Q9LID6 107 7 -
GLVGTNGIGKSTALKILSGKMKPNLG O60102 107 7 -
GLVGTNGIGKSTALKILAGKQKPNLG Q9U2K8 118 7 -
GLVGANGTGKSTALSVLKGRIRPNLG Q9GRP4 115 7 -
GIVGPNGTGKTTAVKILAGQLIPNLC O58589 103 7 -
GIVGPNGTGKTTAVKILAGQLIPNLC Q9UZA4 107 7 -
GIIGQNGIGKSTVLRILAGELIPNLG Y719_METJA 114 6 -
GVLGKNGVGKTTVLKILAGEIIPNFG Q980K5 103 7 -
GILGRNALGKTTMAKILAGELVPNLC Q8ZVC5 102 7 -
GLIGPNGIGKSTIVRILSGELRPNLG O27730 134 7 -
GILGPNGTGKSTAIKILSGQLKPNLG O30231 101 7 -
GLLGPNGIGKSTAVDLLAGEVTPNLG Q9HMC1 113 7 -
GLLGRNGTGKTTALRILAGELKPNLG Q9YCZ3 100 7 -
AILGQNGLGKTTTLNILSGITVPNLG Q9HI55 102 7 -
GILGKNSTGKSTILRILSGELIPNFG Q975V6 103 7 -
AILGQNGLGKTTTLNILSGITVPNLG Q977Z2 105 7 -
GLIGANGIGKSTSFKIIAGELYPNFG Q98SB3 111 7 -

Motif 5 width=17
Element Seqn Id St Int Rpt
WQEILTYFRGSELQNYF Q96B10 140 7 -
WQEILTYFRGSELQNYF Q99K66 140 7 -
WQEILTHFRGSELQNYF O49679 140 7 -
WQEILTYFRGSELKNYF O88793 140 7 -
WQEILTYFRGSELQNYF Q93YY0 140 7 -
WTEILSYFRGSELQNYF Q9VSS1 148 7 -
WQEIIKYFRGSELQNYF Q03195 140 7 -
WQEILTYFRGSELQNYF Q13181 140 7 -
WEEILTHFRGSELQSYF Q9LID6 140 7 -
WAEVVKYFRGSELQNFF O60102 140 7 -
WTTIINHFRGSELQNYF Q9U2K8 151 7 -
WDEILKYFRGSEHQAYF Q9GRP4 148 7 -
WDDVIKAFRGSELQNYF O58589 134 5 -
WDNVIRAFRGNELQNYF Q9UZA4 138 5 -
YDDVIKYFRGTELQEYF Y719_METJA 147 7 -
KDEVLKRFRGKEIYNYF Q980K5 136 7 -
AEDVIRQFRGTELQTYF Q8ZVC5 135 7 -
WDEIINHFRGSQLQNYF O27730 167 7 -
WEEIFDRFAGTELLDYL O30231 132 5 -
WDEVVDEYRGTELQDYL Q9HMC1 146 7 -
WDEILKRFRGSELQTYF Q9YCZ3 134 8 -
KEEVIEKFARTEMGAYF Q9HI55 135 7 -
TDEVLDHFKGKEIYDYF Q975V6 136 7 -
KDAVIDRFARTTMGAYF Q977Z2 138 7 -
YKETVKLFKGSELFYFF Q98SB3 144 7 -

Motif 6 width=27
Element Seqn Id St Int Rpt
FTKILEDDLKAIIKPQYVDQIPKAAKG Q96B10 156 -1 -
FTKILEDDLKAIIKPQYVDQIPKAAKG Q99K66 156 -1 -
FTRILEDNLKAIIKPQYVDHIPRAVKG O49679 156 -1 -
FTTILEDDLKAIIKPQYVDQIPKAAKG O88793 156 -1 -
FTRILEDNLKAIIKPQYVDHIPKAVQG Q93YY0 156 -1 -
FTKILEDNLKALVKPQYVDQIPKAVRG Q9VSS1 164 -1 -
FTKMLEDDIKAIIKPQYVDNIPRAIKG Q03195 156 -1 -
FTKILEDDLKAIIKPQYVARFLRLAKG Q13181 156 -1 -
FIRVVEENLKTAIKPQHVDYIKEVVRG Q9LID6 156 -1 -
FTKVVEDNIKALIKPQYVDHIPRAIKT O60102 156 -1 -
FTRILEDTLKCVIKPQYVDQIPRAAKG Q9U2K8 167 -1 -
FQHLLDDKMRVLLKPQYVDKVPKTNNG Q9GRP4 164 -1 -
FEKLKNGEIKPVVKPQYVDLLPKAVKG O58589 150 -1 -
FERLKNGEIRPVVKPQYVDLLPKAVKG Q9UZA4 154 -1 -
FEKLKNKGVKAIHKVQYVDILPKVVKG Y719_METJA 163 -1 -
FKELYSNELKIVHKIQYVEYASKFLKG Q980K5 152 -1 -
FSELYSNKLRAVHKIQYIELIPIYLKG Q8ZVC5 151 -1 -
FQRLSKGEISVVHKPQMVDRIPRYVKG O27730 183 -1 -
LKGIKEGAIRVSQKPQYIEAIPKVYSG O30231 148 -1 -
LAAVRDGDVDVAKKPQYVDEIPAQFDG Q9HMC1 162 -1 -
FRKLVDGKLRVAHKIQYVELVPRRLKG Q9YCZ3 150 -1 -
FRGLYEQNKRAVLKNQYVDYIPKVVKG Q9HI55 151 -1 -
FYQLYNKKIRVAHKIQYVEYAAKYLKG Q975V6 152 -1 -
FKGLYEENKRAVLKNQYVDYIPKVVSG Q977Z2 154 -1 -
FQEFEKKKITVSIKTQNVEKLRETFNG Q98SB3 160 -1 -