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PR01862

Identifier
BCL2FAMILY  [View Relations]  [View Alignment]  
Accession
PR01862
No. of Motifs
3
Creation Date
04-MAY-2005
Title
Bcl-2 apoptosis regulator protein family signature
Database References
PRINTS; PR01863 APOPREGBCL2; PR01865 APOPREGBCLW; PR01864 APOPREGBCLX
PRINTS; PR01866 APOPREGMCL1; PR01867 BCL2RLATEDA1
PROSITE; PS50062 ; BCL2_FAMILY
PFAM; PF00452 Bcl-2
INTERPRO; IPR002475
MIM; 151430
Literature References
1. HUNOT, S. AND FLAVELL, R.A.
Apoptosis: death of a monopoly?
SCIENCE 292 865-866 (2001).
 
2. GERMAIN, M. AND SHORE, G.C.
Cellular distribution of Bcl-2 family proteins.
SCI.STKE 173 PE10 (2003).
 
3. ADAMS, J.M. AND CORY, S.
The Bcl-2 protein family: arbiters of cell survival.
SCIENCE 281 1322-1326 (1998).

Documentation
Apoptosis, or programmed cell death (PCD), is a common and evolutionarily 
conserved property of all metazoans [1]. In many biological processes, 
apoptosis is required to eliminate supernumerary or dangerous (e.g., pre-
cancerous) cells and to promote normal development. Thus, dysregulation  
of apoptosis can contribute to the development of many major diseases, 
including cancer, autoimmunity and neurodegenerative disorders. In most
cases, proteins of the caspase family execute the genetic programme that
leads to cell death. Bcl-2 proteins are central regulators of caspase
activation, and play a key role in cell death by regulating the integrity
of the mitochondrial and endoplasmic reticulum (ER) membranes [2]. At 
least 20 Bcl-2 proteins have been reported in mammals, and several
others have been identified in viruses.
 
Bcl-2 family proteins fall roughly into three subtypes, which either promote 
cell survival (anti-apoptotic) or trigger cell death (pro-apoptotic). All 
members contain at least one of four conserved motifs, termed Bcl-2 Homology
(BH) domains. Bcl-2 subfamily proteins, which contain at least BH1 and BH2,
promote cell survival by inhibiting the adapters needed for the activation
of caspases. Pro-apoptotic members potentially exert their effects by dis-
placing the adapters from the pro-survival proteins; these proteins belong
either to the Bax subfamily, which contain BH1-BH3, or to the BH3 subfamily,
which mostly only feature BH3 [3]. Thus, the balance between antagonistic
family members is believed to play a role in determining cell fate.
 
Members of the wider Bcl-2 family, which also includes Bcl-x, Bcl-w and 
Mcl-1, are described by their similarity to Bcl-2 protein, a member of
the pro-survival Bcl-2 subfamily [3]. 
 
BCL2FAMILY is a 3-element fingerprint that provides a signature for the 
Bcl-2 apoptosis regulator protein family. The fingerprint was derived 
from an initial alignment of 21 sequences: the motifs were drawn from
conserved regions spanning the C-terminal half of the alignment - motif 1
includes the N-terminus of BH1; motif 2 includes the C-terminus of BH1; and
motif 3 includes the N-terminus of BH2. Four iterations on SPTR44_27f were
required to reach convergence, at which point a true set comprising 83
sequences was identified. Numerous partial matches were also found, most of
which appear to be related members of the Bcl-2 family that fail to make
a significant match with motif 1.
Summary Information
  83 codes involving  3 elements
20 codes involving 2 elements
Composite Feature Index
3838383
222018
123
True Positives
AR11_XENLA    BAXA_BOVIN    BAXA_HUMAN    BAXA_MOUSE    
BAXA_RAT BAXB_HUMAN BAXD_HUMAN BCL2_BOVIN
BCL2_CHICK BCL2_CRILO BCL2_HUMAN BCL2_MOUSE
BCL2_RAT BCLW_HUMAN BCLW_MOUSE BCLX_CHICK
BCLX_HUMAN BCLX_MOUSE BCLX_PIG BCLX_RAT
BFL1_HUMAN BFL1_MOUSE EAR_ASFB7 EAR_ASFE4
EAR_ASFM2 MCL1_HUMAN O35425 O35843
O55177 O55179 O88996 P97287
Q6AYY5 Q6GLI5 Q6GP82 Q6NTH7
Q6P4Y4 Q6R755 Q75SV7 Q76LT7
Q792S6 Q7TS60 Q7TS62 Q7TSN8
Q7YRZ9 Q86W13 Q8BEN2 Q8BQK4
Q8C5P0 Q8CFR2 Q8CGL4 Q8HYS5
Q8HYU5 Q8I008 Q8K164 Q8K3J2
Q8SQ42 Q8SQ43 Q8UWD5 Q8UWD6
Q8WZ49 Q90Z98 Q90ZH2 Q923R6
Q925A9 Q95KR3 Q967D2 Q98U13
Q9CYW5 Q9DGJ5 Q9I8I2 Q9I9N4
Q9JKL3 Q9MYW4 Q9MZS7 Q9N1A2
Q9NR76 Q9NYG7 Q9UL32 Q9UMX3
Q9UNJ1 Q9W6F2 Q9Z1P3
True Positive Partials
Codes involving 2 elements
BCLB_HUMAN NR13_COTJA O55178 O88857
Q677S5 Q6DC66 Q7KJ42 Q7KM33
Q7T381 Q804D0 Q8T8Y5 Q90ZN1
Q99M66 Q9DH00 Q9E1F2 Q9I9N3
Q9N754 Q9N9X1 Q9UQD6 Q9V9C8
Sequence Titles
AR11_XENLA  Apoptosis regulator R11 (XR11) - Xenopus laevis (African clawed frog). 
BAXA_BOVIN Apoptosis regulator BAX, membrane isoform alpha - Bos taurus (Bovine).
BAXA_HUMAN Apoptosis regulator BAX, membrane isoform alpha - Homo sapiens (Human).
BAXA_MOUSE Apoptosis regulator BAX, membrane isoform alpha - Mus musculus (Mouse).
BAXA_RAT Apoptosis regulator BAX, membrane isoform alpha - Rattus norvegicus (Rat).
BAXB_HUMAN Apoptosis regulator BAX, cytoplasmic isoform beta - Homo sapiens (Human).
BAXD_HUMAN BAX protein, cytoplasmic isoform delta - Homo sapiens (Human).
BCL2_BOVIN Apoptosis regulator Bcl-2 - Bos taurus (Bovine).
BCL2_CHICK Apoptosis regulator Bcl-2 - Gallus gallus (Chicken).
BCL2_CRILO Apoptosis regulator Bcl-2 - Cricetulus longicaudatus (Long-tailed hamster) (Chinese hamster).
BCL2_HUMAN Apoptosis regulator Bcl-2 - Homo sapiens (Human).
BCL2_MOUSE Apoptosis regulator Bcl-2 - Mus musculus (Mouse).
BCL2_RAT Apoptosis regulator Bcl-2 - Rattus norvegicus (Rat).
BCLW_HUMAN Apoptosis regulator Bcl-W (BCL2-like 2 protein) - Homo sapiens (Human).
BCLW_MOUSE Apoptosis regulator Bcl-W (BCL2-like 2 protein) - Mus musculus (Mouse).
BCLX_CHICK Apoptosis regulator Bcl-X (BCL2-like 1 protein) - Gallus gallus (Chicken).
BCLX_HUMAN Apoptosis regulator Bcl-X (BCL2-like 1 protein) - Homo sapiens (Human).
BCLX_MOUSE Apoptosis regulator Bcl-X (BCL2-like 1 protein) - Mus musculus (Mouse).
BCLX_PIG Apoptosis regulator Bcl-X (BCL2-like 1 protein) - Sus scrofa (Pig).
BCLX_RAT Apoptosis regulator Bcl-X (BCL2-like 1 protein) - Rattus norvegicus (Rat).
BFL1_HUMAN Bcl-2-related protein A1 (BFL-1 protein) (Hemopoietic-specific early response protein) (GRS protein) - Homo sapiens (Human).
BFL1_MOUSE Bcl-2-related protein A1 (BFL-1 protein) (Hemopoietic-specific early response protein) (A1-A) - Mus musculus (Mouse).
EAR_ASFB7 Apoptosis regulator Bcl-2 homolog precursor - African swine fever virus (strain BA71V) (ASFV).
EAR_ASFE4 Apoptosis regulator Bcl-2 homolog precursor (LMH-5W) - African swine fever virus (strain E-70 / isolate MS44) (ASFV).
EAR_ASFM2 Apoptosis regulator Bcl-2 homolog precursor (LMH-5W) - African swine fever virus (isolate Malawi Lil 20/1) (ASFV).
MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 - Homo sapiens (Human).
O35425 Bcl-2-related ovarian killer protein-like (Apoptosis activator Mtd) - Mus musculus (Mouse).
O35843 Bcl-x-gamma - Mus musculus (Mouse).
O55177 A1-b protein - Mus musculus (Mouse).
O55179 B-cell leukemia/lymphoma 2 related protein A1d - Mus musculus (Mouse).
O88996 Bcl-w - Rattus norvegicus (Rat).
P97287 EAT/MCL-1 PROTEIN (MCL1) (MYELOID CELL LEUKEMIA SEQUENCE 1) - Mus musculus (Mouse).
Q6AYY5 Myeloid cell leukemia sequence 1 - Rattus norvegicus (Rat).
Q6GLI5 Bcl2l1-prov protein - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q6GP82 MGC80617 protein - Xenopus laevis (African clawed frog).
Q6NTH7 B-cell leukemia/lymphoma 2 - Mus musculus (Mouse).
Q6P4Y4 Hypothetical protein MGC76049 - Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Q6R755 Bcl-2 - Canis familiaris (Dog).
Q75SV7 Bcl-2 protein - Canis familiaris (Dog).
Q76LT7 Bcl-xL - Canis familiaris (Dog).
Q792S6 Bcl-2-related ovarian killer protein - Rattus norvegicus (Rat).
Q7TS60 BCL-WEL - Rattus norvegicus (Rat).
Q7TS62 Bcl-xbeta - Rattus norvegicus (Rat).
Q7TSN8 Bcl2-like protein - Rattus norvegicus (Rat).
Q7YRZ9 Mcl-1 - Felis silvestris catus (Cat).
Q86W13 A1 splice variant - Homo sapiens (Human).
Q8BEN2 ORF64 - Callitrichine herpesvirus 3.
Q8BQK4 Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430015F12 product:B-cell leukemia/lymphoma 2, full insert sequence - Mus musculus (Mouse).
Q8C5P0 Mus musculus 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030439K11 product:B-cell leukemia/lymphoma 2, full insert sequence - Mus musculus (Mouse).
Q8CFR2 Bcl2l2 protein - Mus musculus (Mouse).
Q8CGL4 Bcl2-like protein 2 - Mus musculus (Mouse).
Q8HYS5 Mcl-1 - Canis familiaris (Dog).
Q8HYU5 Bax - Canis familiaris (Dog).
Q8I008 Bcl-2 protein - Felis silvestris catus (Cat).
Q8K164 B-cell leukemia/lymphoma 2 related protein A1b - Mus musculus (Mouse).
Q8K3J2 Bcl2-associated X protein kappa isoform - Mus musculus (Mouse).
Q8SQ42 Bcl-xl protein - Felis silvestris catus (Cat).
Q8SQ43 Bax-protein - Felis silvestris catus (Cat).
Q8UWD5 Nr13 - Brachydanio rerio (Zebrafish) (Danio rerio).
Q8UWD6 Mcl1b - Brachydanio rerio (Zebrafish) (Danio rerio).
Q8WZ49 Bax isoform psi - Homo sapiens (Human).
Q90Z98 Bcl-XL-like protein 1 - Brachydanio rerio (Zebrafish) (Danio rerio).
Q90ZH2 Bcl-XL - Xenopus laevis (African clawed frog).
Q923R6 B-cell lymphoma protein 2 - Cricetulus longicaudatus (Long-tailed hamster) (Chinese hamster).
Q925A9 BCL2-related protein A1 - Rattus norvegicus (Rat).
Q95KR3 MYELOID CELL LEUKEMIA PROTEIN 1 - Sus scrofa (Pig).
Q967D2 Bcl-x homologous protein, BHP2 - Geodia cydonium (Sponge).
Q98U13 Bax - Xenopus laevis (African clawed frog).
Q9CYW5 Bcl2-like 2 - Mus musculus (Mouse).
Q9DGJ5 Bcl-2-related ovarian killer protein - Gallus gallus (Chicken).
Q9I8I2 Bcl-2-related ovarian killer protein - Gallus gallus (Chicken).
Q9I9N4 Bax (Bcl2-associated X protein) - Brachydanio rerio (Zebrafish) (Danio rerio).
Q9JKL3 Bax protein splice variant k - Rattus norvegicus (Rat).
Q9MYW4 Bcl-X - Oryctolagus cuniculus (Rabbit).
Q9MZS7 Bcl-x long protein - Ovis aries (Sheep).
Q9N1A2 Anti-apoptotic regulator Bcl-xL - Sus scrofa (Pig).
Q9NR76 Bax zeta - Homo sapiens (Human).
Q9NYG7 Bax-sigma - Homo sapiens (Human).
Q9UL32 Bcl-2 related ovarian killer - Homo sapiens (Human).
Q9UMX3 BCL-2-related ovarian killer protein (BOK protein) - Homo sapiens (Human).
Q9UNJ1 MYELOID CELL DIFFERENTIATION PROTEIN (MYELOID CELL LEUKEMIA PROTEIN 1) (MYELOID CELL LEUKEMIA SEQUENCE 1) (BCL2-RELATED) - Homo sapiens (Human).
Q9W6F2 Protein A1 - Gallus gallus (Chicken).
Q9Z1P3 MCL-1 PROTEIN - Rattus norvegicus (Rat).

BCLB_HUMAN Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Anti-apoptotic protein NrH) - Homo sapiens (Human).
NR13_COTJA Apoptosis regulator NR-13 - Coturnix coturnix japonica (Japanese quail).
O55178 A1-c protein - Mus musculus (Mouse).
O88857 Bcl-2-related ovarian killer protein - Rattus norvegicus (Rat).
Q677S5 Hypothetical protein - Lymphocystis disease virus - isolate China.
Q6DC66 Zgc:100979 protein - Brachydanio rerio (Zebrafish) (Danio rerio).
Q7KJ42 Pro-apoptotic Bcl-2/Bax-like protein - Drosophila melanogaster (Fruit fly).
Q7KM33 Bcl-2 family member protein - Drosophila melanogaster (Fruit fly).
Q7T381 Similar to BCL2-related ovarian killer - Brachydanio rerio (Zebrafish) (Danio rerio).
Q804D0 Bcl-2 related anti-apoptotic protein - Gallus gallus (Chicken).
Q8T8Y5 AT16536p (CG8238-PA) - Drosophila melanogaster (Fruit fly).
Q90ZN1 Anti-apoptotic NR13 - Gallus gallus (Chicken).
Q99M66 BCL2L10 - Rattus norvegicus (Rat).
Q9DH00 Similar to Apoptosis inhibitor, Bcl2 family proteins (Apoptosis inhibitor-like protein) - Meleagrid herpesvirus 1 (herpesvirus of turkeys).
Q9E1F2 RSORF1 N13-like protein - Meleagrid herpesvirus 1 (herpesvirus of turkeys).
Q9I9N3 MCL-1A (CELL DEATH REGULATOR MCL-1A) - Brachydanio rerio (Zebrafish) (Zebra danio).
Q9N754 BHP1 protein - Suberites domuncula (Sponge).
Q9N9X1 BHP1 protein (BHP1g protein) - Geodia cydonium (Sponge).
Q9UQD6 Bax epsilon - Homo sapiens (Human).
Q9V9C8 Drob-1 (BG1) (Bcl-2 ortholog dBorg-1) (CG33134-PA) (Proapoptotic Bcl-2 homolog DEBCL) - Drosophila melanogaster (Fruit fly).
Scan History
SPTR44_27f 4  400  NSINGLE    
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
FATVVEELFRDGV BCL2_CRILO 127 127 -
FATVVEELFRDGV BCL2_HUMAN 130 130 -
FATVVEELFRDGV BCL2_MOUSE 127 127 -
FATVVEELFRDGV BCL2_RAT 127 127 -
FATVVEELFRDGV BCL2_BOVIN 120 120 -
FEQVVNELFRDGV Q9N1A2 123 123 -
FEQVVNELFRDGV Q8SQ42 123 123 -
FVAVVEELFRDGV BCL2_CHICK 124 124 -
FESVMDEVFRDGV Q90Z98 126 126 -
FQQVMGELFRDGT Q90ZH2 95 95 -
FTQVSDELFQGGP O88996 79 79 -
FTQVSDELFQGGP BCLW_HUMAN 79 79 -
FTQVSDELFQGGP BCLW_MOUSE 79 79 -
FNQVMEKEFEDGI Q925A9 71 71 -
FNQVMEKEFEDGI O55179 71 71 -
FNQVMEKEFEDGI O55177 71 71 -
FNQVMEKEFEDGI BFL1_MOUSE 71 71 -
FNQVMEKEFEDGI BFL1_HUMAN 71 71 -
FSRVMTHVFKDGV Q9Z1P3 226 226 -
FSRVMVHVFKDGV P97287 227 227 -
LSRVMIHVFSDGV MCL1_HUMAN 246 246 -

Motif 2 width=29
Element Seqn Id St Int Rpt
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_CRILO 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_HUMAN 143 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_MOUSE 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_RAT 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_BOVIN 133 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q9N1A2 136 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q8SQ42 136 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_CHICK 137 0 -
NWGRIVGLFAFGGALCVECVEKEMSPLVG Q90Z98 139 0 -
NWGRIVAFFSFGRALCVESANKEMTDLLP Q90ZH2 108 0 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG O88996 92 0 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG BCLW_HUMAN 92 0 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG BCLW_MOUSE 92 0 -
NWGRIVTIFAFGGVLLKKLPQEQIGLDVD Q925A9 85 1 -
NWGRIVTIFAFGGVLLKKLPQEQIALDVG O55179 85 1 -
NWGRIVTIFAFGGVLLKKLPQEQIALDVG O55177 85 1 -
NWGRIVTIFAFGGVLLKKLPQEQIALDVC BFL1_MOUSE 85 1 -
NWGRIVTIFAFEGILIKKLLRQQIAPDVD BFL1_HUMAN 85 1 -
NWGRIVTLISFGAFVAKHLKSINQESCIE Q9Z1P3 240 1 -
NWGRIVTLISFGAFVAKHLKSVNQESFIE P97287 241 1 -
NWGRIVTLISFGAFVAKHLKTINQESCIE MCL1_HUMAN 260 1 -

Motif 3 width=25
Element Seqn Id St Int Rpt
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_CRILO 169 0 -
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_HUMAN 172 0 -
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_MOUSE 169 0 -
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_RAT 169 0 -
SIALWMTEYLNRHLHTWIQDNGGWD BCL2_BOVIN 162 0 -
RIATWMATYLNDHLEPWIQENGGWD Q9N1A2 165 0 -
RIAAWMATYLNDHLEPWIQENGGWD Q8SQ42 165 0 -
NIATWMTEYLNRHLHNWIQDNGGWD BCL2_CHICK 166 0 -
RIAEWMTVYLDNHIQPWIQSQGGWE Q90Z98 168 0 -
RIVQWMVNYLEHTLQPWMQENGGWE Q90ZH2 137 0 -
QVQDWMVTYLETRLADWIHSSGGWA O88996 121 0 -
QVQEWMVAYLETRLADWIHSSGGWA BCLW_HUMAN 121 0 -
QVQDWMVAYLETRLADWIHSSGGWA BCLW_MOUSE 121 0 -
QVSSFVAEFIMNNTGEWIQQNGGWE Q925A9 117 3 -
QVSSFVAEFIMNNTGEWIRRNGGWE O55179 117 3 -
QVSSFVAEFIINNTGEWIRRNGGWE O55177 117 3 -
QVSSFVAEFIMNNTGEWIRQNGGWE BFL1_MOUSE 117 3 -
EISYFVAEFIMNNTGEWIRQNGGWE BFL1_HUMAN 117 3 -
PLAESITDVLVRTKRDWLVKQRGWD Q9Z1P3 269 0 -
PLAETITDVLVRTKRDWLVKQRGWD P97287 270 0 -
PLAESITDVLVRTKRDWLVKQRGWD MCL1_HUMAN 289 0 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
FATVVEELFRDGV BCL2_CRILO 127 127 -
FATVVEELFRDGV BCL2_HUMAN 130 130 -
FATVVEELFRDGV BCL2_MOUSE 127 127 -
FATVVEELFRDGV BCL2_RAT 127 127 -
FATVVEELFRDGV Q6R755 127 127 -
FATVVEELFRDGV Q75SV7 130 130 -
FATVVEELFRDGV Q7TSN8 127 127 -
FATVVEELFRDGV Q8BQK4 127 127 -
FATVVEELFRDGV Q923R6 127 127 -
FEQVVNELFRDGV BCLX_MOUSE 123 123 -
FEQVVNELFRDGV BCLX_RAT 123 123 -
FATVVEELFRDGV BCL2_BOVIN 120 120 -
FEQVVNELFRDGV Q9MYW4 123 123 -
FEQVVNELFRDGV Q9MZS7 123 123 -
FEQVVNELFRDGV Q9N1A2 123 123 -
FEQVVNELFRDGV BCLX_HUMAN 123 123 -
FEQVVNELFRDGV Q76LT7 123 123 -
FEQVVNELFRDGV Q8SQ42 123 123 -
FATVVEELFRDGV Q8I008 126 126 -
FATVVEELFRDGV Q6NTH7 127 127 -
FEQVVNELFRDGV Q7TS62 123 123 -
FEQVVNELFRDGV O35843 123 123 -
FVAVVEELFRDGV BCL2_CHICK 124 124 -
FEQVLNELFRDGV BCLX_PIG 123 123 -
FATVVEELFRDGV Q8C5P0 127 127 -
FEQVVNELFHDGV BCLX_CHICK 119 119 -
FESVMDEVFRDGV Q90Z98 126 126 -
FQQVMGELFRDGT AR11_XENLA 95 95 -
FQQVMGELFRDGT Q90ZH2 95 95 -
FQQVVGELFRDGT Q6GLI5 91 91 -
FFRVAAEMFSDGN BAXA_BOVIN 92 92 -
FFRVAAEMFSDGN Q8HYU5 92 92 -
FFRVAAEMFSDGN Q8SQ43 92 92 -
FAEVAGSLFQGGV Q6GP82 74 74 -
FFRVAADMFSDGN BAXA_HUMAN 92 92 -
FFRVAADMFSDGN BAXD_HUMAN 43 43 -
FFRVAADMFSDGN Q8WZ49 73 73 -
FFRVAADMFSDGN Q9NR76 14 14 -
FFRVAADMFADGN BAXA_RAT 92 92 -
FFRVAADMFADGN Q9JKL3 73 73 -
FTQVSDELFQGGP O88996 79 79 -
FTQVSDELFQGGP Q7TS60 105 105 -
FFRVAADMFSDGN BAXB_HUMAN 92 92 -
FFRVAADMFSDGN Q9NYG7 92 92 -
FTQVSDELFQGGP BCLW_HUMAN 79 79 -
FTQVSDELFQGGP BCLW_MOUSE 79 79 -
FTQVSDELFQGGP Q8CFR2 79 79 -
FTQVSDELFQGGP Q9CYW5 79 79 -
FFRVAADMFADGN BAXA_MOUSE 92 92 -
FFRVAADMFADGN Q8K3J2 73 73 -
FTQVSDELFQGGP Q8CGL4 79 79 -
FFHVAKELFADGV Q6P4Y4 122 122 -
FFHVAKELFADGV Q98U13 122 122 -
FIRVAREIFSDGK Q9I9N4 94 94 -
FNQVMEKEFEDGI Q925A9 71 71 -
FNQVMEKEFEDGI O55179 71 71 -
FNQVMEKEFEDGI O55177 71 71 -
FNQVMEKEFEDGI Q8K164 71 71 -
FNQVMEKEFEDGI BFL1_MOUSE 71 71 -
FNQVMEKEFEDGI BFL1_HUMAN 71 71 -
FNQVMEKEFEDGI Q86W13 71 71 -
FSRVMTHVFKDGV Q6AYY5 226 226 -
FSRVMTHVFKDGV Q9Z1P3 226 226 -
FSRVMVHVFKDGV P97287 227 227 -
FNGVMEEKFADGN Q9W6F2 71 71 -
LSRVMVHVFSDGV Q7YRZ9 246 246 -
LSRVMIHVFSDGV MCL1_HUMAN 246 246 -
LSRVMIHVFSDGV Q9UNJ1 246 246 -
LSRVIVHVFSDGV Q8HYS5 246 246 -
IKQVATELFSDGT Q8UWD6 124 124 -
LQSVMRELVGDGK Q8UWD5 69 69 -
LSRVMVHVLSDGV Q95KR3 48 48 -
FLAVAGHIFSAGI O35425 107 107 -
FLAVAGHIFSAGI Q792S6 107 107 -
FLAVAGHIFSAGI Q9UL32 107 107 -
FLAVAGHIFSAGI Q9UMX3 106 106 -
FLAVAAQIFTAGI Q9DGJ5 107 107 -
FLAVAAQIFTAGI Q9I8I2 107 107 -
FTGVVTELFRDLI EAR_ASFE4 70 70 -
FTGVVTELFKDLI EAR_ASFB7 70 70 -
FTGVVTELFKDLI EAR_ASFM2 70 70 -
IWGVQEELFGDGC Q8BEN2 79 79 -
FREVERRTFSDGV Q967D2 119 119 -

Motif 2 width=29
Element Seqn Id St Int Rpt
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_CRILO 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_HUMAN 143 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_MOUSE 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_RAT 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q6R755 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q75SV7 143 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q7TSN8 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q8BQK4 140 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q923R6 140 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS BCLX_MOUSE 136 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS BCLX_RAT 136 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_BOVIN 133 0 -
NWGRIVAFFSFGGALCVESVDKEMEVLVS Q9MYW4 136 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q9MZS7 136 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q9N1A2 136 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS BCLX_HUMAN 136 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q76LT7 136 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q8SQ42 136 0 -
NWGRIVAFFEFGGVMCVEGVNREMSPLVD Q8I008 139 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD Q6NTH7 140 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS Q7TS62 136 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS O35843 136 0 -
NWGRIVAFFEFGGVMCVESVNREMSPLVD BCL2_CHICK 137 0 -
NWGRIVAFFSFGGALCVESVDKEMQVLVS BCLX_PIG 136 0 -
NWGRIVAFLEFGGVMCVESVNREMSPLVD Q8C5P0 140 0 -
NWGRIVAFFSFGGALCVESVDKEMRVLVG BCLX_CHICK 132 0 -
NWGRIVGLFAFGGALCVECVEKEMSPLVG Q90Z98 139 0 -
NWGRIVAFFSFGRALCVESANKEMTDLLP AR11_XENLA 108 0 -
NWGRIVAFFSFGRALCVESANKEMTDLLP Q90ZH2 108 0 -
NWGRIVAFFSFGRALCVESANKEMTELLP Q6GLI5 104 0 -
NWGRVVALFYFASKLVLKALCTKVPELIR BAXA_BOVIN 106 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR Q8HYU5 106 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR Q8SQ43 106 1 -
NWGRIVAFFVFGAALCAESVNKEMSPLLP Q6GP82 87 0 -
NWGRVVALFYFASKLVLKALCTKVPELIR BAXA_HUMAN 106 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR BAXD_HUMAN 57 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR Q8WZ49 87 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR Q9NR76 28 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR BAXA_RAT 106 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR Q9JKL3 87 1 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG O88996 92 0 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG Q7TS60 118 0 -
NWGRVVALFYFASKLVLKALCTKVPELIR BAXB_HUMAN 106 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR Q9NYG7 106 1 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG BCLW_HUMAN 92 0 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG BCLW_MOUSE 92 0 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG Q8CFR2 92 0 -
NWGRLVAFFVFGAALCAESVNKEMEPLVG Q9CYW5 92 0 -
NWGRVVALFYFASKLVLKALCTKVPELIR BAXA_MOUSE 106 1 -
NWGRVVALFYFASKLVLKALCTKVPELIR Q8K3J2 87 1 -
NWGRLVAFFVFGAALCAESVNKHMEPLVG Q8CGL4 92 0 -
NWGRVVALFYFACKLVVKALCTKVPEMIR Q6P4Y4 136 1 -
NWGRVVALFYFACKLVVKALCTKVPEMIR Q98U13 136 1 -
NWGRVVALFYFACRLVIKAISTRVPDIIR Q9I9N4 108 1 -
NWGRIVTIFAFGGVLLKKLPQEQIGLDVD Q925A9 85 1 -
NWGRIVTIFAFGGVLLKKLPQEQIALDVG O55179 85 1 -
NWGRIVTIFAFGGVLLKKLPQEQIALDVG O55177 85 1 -
NWGRIVTIFAFGGVLLKKLPQEQIALDVG Q8K164 85 1 -
NWGRIVTIFAFGGVLLKKLPQEQIALDVC BFL1_MOUSE 85 1 -
NWGRIVTIFAFEGILIKKLLRQQIAPDVD BFL1_HUMAN 85 1 -
NWGRIVTIFAFEGILIKKLLRQQIAPDVD Q86W13 85 1 -
NWGRIVTLISFGAFVAKHLKSINQESCIE Q6AYY5 240 1 -
NWGRIVTLISFGAFVAKHLKSINQESCIE Q9Z1P3 240 1 -
NWGRIVTLISFGAFVAKHLKSVNQESFIE P97287 241 1 -
NWGRIMTIFTFGGLLTKKLQEHGVQLTGE Q9W6F2 85 1 -
NWGRIVTLISFGAFVAKHLKSINQESCIE Q7YRZ9 260 1 -
NWGRIVTLISFGAFVAKHLKTINQESCIE MCL1_HUMAN 260 1 -
NWGRIVTLISFGAFVAKHLKTINQESCIE Q9UNJ1 260 1 -
NWGRIVTLISFGAFVAKHLKSINQESCIE Q8HYS5 260 1 -
NWGRIASLLTFGAMLCKYQNDRGHSKYVR Q8UWD6 138 1 -
NWGRVVSIFTFTGVLASELLSRGENSEGS Q8UWD5 83 1 -
NWGRIVTLISFGAFVAKHLKSINQESCIE Q95KR3 62 1 -
TWGKVVSLYSVAAGLAVDCVRQAQPAMVH O35425 120 0 -
TWGKVVSLYSVAAGLAVDCVRQAQPAMVH Q792S6 120 0 -
TWGKVVSLYSAAAGLAVDCVRQAQPAMVH Q9UL32 120 0 -
TWGKVVSLYAVAAGLAVDCVRQAQPAMVH Q9UMX3 119 0 -
TWGKVVSLYAVAAGLAVDCVRHAQPAMVH Q9DGJ5 120 0 -
TWGKVVSLYAVAAGLAVDCVRHAQPAMVH Q9I8I2 120 0 -
NWGRICGFIVFSARMAKYCKDANNHLEST EAR_ASFE4 83 0 -
NWGRICGFIVFSAKMAKYCKDANNHLEST EAR_ASFB7 83 0 -
NWGRICGFIVFSARMAKYCKDANNHLEST EAR_ASFM2 83 0 -
NWGRIVVWLAWCCFMCRCTRCCEDYNLVD Q8BEN2 92 0 -
HWGRVIAFLAFSMSFAAYVNSRGIDGGAY Q967D2 132 0 -

Motif 3 width=25
Element Seqn Id St Int Rpt
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_CRILO 169 0 -
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_HUMAN 172 0 -
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_MOUSE 169 0 -
NIALWMTEYLNRHLHTWIQDNGGWD BCL2_RAT 169 0 -
NIALWMTEYLNRHLHTWIQDNGGWD Q6R755 169 0 -
NIALWMTEYLNRHLHTWIQDNGGWD Q75SV7 172 0 -
NIALWMTEYLNRHLHTWIQDNGGWD Q7TSN8 169 0 -
NIALWMTEYLNRHLHTWIQDNGGWD Q8BQK4 169 0 -
NIALWMTEYLNRHLHTWIQDNGGWD Q923R6 169 0 -
RIASWMATYLNDHLEPWIQENGGWD BCLX_MOUSE 165 0 -
RIASWMATYLNDHLEPWIQENGGWD BCLX_RAT 165 0 -
SIALWMTEYLNRHLHTWIQDNGGWD BCL2_BOVIN 162 0 -
RIAAWMATYLNDHLEPWIQENGGWD Q9MYW4 165 0 -
RIATWMATYLNDHLEPWIQENGGWD Q9MZS7 165 0 -
RIATWMATYLNDHLEPWIQENGGWD Q9N1A2 165 0 -
RIAAWMATYLNDHLEPWIQENGGWD BCLX_HUMAN 165 0 -
RIAAWMATYLNDHLEPWIQENGGWD Q76LT7 165 0 -
RIAAWMATYLNDHLEPWIQENGGWD Q8SQ42 165 0 -
NIALWMTEYLNRHLHTWIQDNGGWD Q8I008 168 0 -
NIALWMTEYLNRHLHTWIQDNGGWV Q6NTH7 169 0 -
RIASWMATYLNDHLEPWIQENGGWV Q7TS62 165 0 -
RIASWMATYLNDHLEPWIQENGGWG O35843 165 0 -
NIATWMTEYLNRHLHNWIQDNGGWD BCL2_CHICK 166 0 -
RIATWMATYLNDHLEPWIQENGGWD BCLX_PIG 165 0 -
NIALWMTEYLNRHLHTWIQDNGGWV Q8C5P0 169 0 -
RIVSWMTTYLTDHLDPWIQENGGWE BCLX_CHICK 161 0 -
RIAEWMTVYLDNHIQPWIQSQGGWE Q90Z98 168 0 -
RIVQWMVNYLEHTLQPWMQENGGWE AR11_XENLA 137 0 -
RIVQWMVNYLEHTLQPWMQENGGWE Q90ZH2 137 0 -
RIVQWMVQYLEHTLQPWMLENGGWE Q6GLI5 133 0 -
TIMGWTLDFLRERLLGWIQDQGGWD BAXA_BOVIN 135 0 -
TIMGWTLDFLRERLLGWIQDQGGWD Q8HYU5 135 0 -
TIMGWTLDFLRERLLGWIQDQGGWD Q8SQ43 135 0 -
RIQDWMVTYLETNLRGWIQSNGGWN Q6GP82 116 0 -
TIMGWTLDFLRERLLGWIQDQGGWD BAXA_HUMAN 135 0 -
TIMGWTLDFLRERLLGWIQDQGGWD BAXD_HUMAN 86 0 -
TIMGWTLDFLRERLLGWIQDQGGWD Q8WZ49 116 0 -
TIMGWTLDFLRERLLGWIQDQGGWD Q9NR76 57 0 -
TIMGWTLDFLRERLLVWIQDQGGWD BAXA_RAT 135 0 -
TIMGWTLDFLRERLLVWIQDQGGWD Q9JKL3 116 0 -
QVQDWMVTYLETRLADWIHSSGGWA O88996 121 0 -
QVQDWMVTYLETRLADWIHSSGGWA Q7TS60 147 0 -
TIMGWTLDFLRERLLGWIQDQGGWV BAXB_HUMAN 135 0 -
TIMGWTLDFLRERLLGWIQDQGGWT Q9NYG7 135 0 -
QVQEWMVAYLETRLADWIHSSGGWA BCLW_HUMAN 121 0 -
QVQDWMVAYLETRLADWIHSSGGWA BCLW_MOUSE 121 0 -
QVQDWMVAYLETRLADWIHSSGGWV Q8CFR2 121 0 -
QVQDWMVAYLETRLADWIHSSGGWV Q9CYW5 121 0 -
TIMGWTLDFLRERLLVWIQDQGGWE BAXA_MOUSE 135 0 -
TIMGWTLDFLRERLLVWIQDQGGWE Q8K3J2 116 0 -
QVQDWMVAYLETRLAYWIHSSGGWA Q8CGL4 121 0 -
TIINWTMEYLREYVVQWIRDQGGWE Q6P4Y4 165 0 -
TIINWTMDYLRDYVVQWIRDQGGWE Q98U13 165 0 -
TIISWTMSYIQEHVINWIREQGGWD Q9I9N4 137 0 -
QVSSFVAEFIMNNTGEWIQQNGGWE Q925A9 117 3 -
QVSSFVAEFIMNNTGEWIRRNGGWE O55179 117 3 -
QVSSFVAEFIINNTGEWIRRNGGWE O55177 117 3 -
QVSSFVAEFIINNTGEWIRRNGGWE Q8K164 117 3 -
QVSSFVAEFIMNNTGEWIRQNGGWE BFL1_MOUSE 117 3 -
EISYFVAEFIMNNTGEWIRQNGGWE BFL1_HUMAN 117 3 -
EISYFVAEFIMNNTGEWIRQNGGWG Q86W13 117 3 -
PLAESITDVLVRTKRDWLVKQRGWD Q6AYY5 269 0 -
PLAESITDVLVRTKRDWLVKQRGWD Q9Z1P3 269 0 -
PLAETITDVLVRTKRDWLVKQRGWD P97287 270 0 -
KISYFITEYIINNKAAWIDANGGWE Q9W6F2 117 3 -
PLAESITDVLVRTKRDWLVKQRGWD Q7YRZ9 289 0 -
PLAESITDVLVRTKRDWLVKQRGWD MCL1_HUMAN 289 0 -
PLAESITDVLVRTKRDWLVKQRGWD Q9UNJ1 289 0 -
PLAESITDVLVRTKRDWLVKQRGWD Q8HYS5 289 0 -
LVGEEISSYLLTEQRDWILRNKAWD Q8UWD6 167 0 -
RLAETIADYLGGEKQDWLVENGGWE Q8UWD5 113 1 -
PLAESITDVLVRTKRDWLVKQRGWD Q95KR3 91 0 -
ALVDCLGEFVRKTLATWLRRRGGWT O35425 149 0 -
ALVDCLGEFVRKTLATWLRRRGGWT Q792S6 149 0 -
ALVDCLGEFVRKTLATWLRRRGGWT Q9UL32 149 0 -
ALVDCLGEFVRKTLATWLRRRGGWT Q9UMX3 148 0 -
TIVDCLGEFVRKTLVTWLKRRGGWA Q9DGJ5 149 0 -
TIVDCLGEFVRKTLVTWLKRRGGWA Q9I8I2 149 0 -
TVITTAYNFMKHNLLPWMISHGGQE EAR_ASFE4 111 -1 -
TVITTAYNFMKHNLLPWMISHGGQE EAR_ASFB7 111 -1 -
TVITTAYNFMKHNLLPWMISHGGQE EAR_ASFM2 111 -1 -
DAVFRGVLESTEGIDGWIHSHGGWD Q8BEN2 120 -1 -
SVFNWTLRVLNDSLADFIQRENGWR Q967D2 161 0 -