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PR01803

Identifier
TCSIALIDASE  [View Relations]  [View Alignment]  
Accession
PR01803
No. of Motifs
10
Creation Date
29-JUL-2002
Title
Trypanosome sialidase signature
Database References

BLOCKS; IPB004124
PFAM; PF02973 SIALIDASE_N
INTERPRO; IPR004124
Literature References
1. ENGMAN, D.M. AND LEON, J.S.
Pathogenesis of Chagas heart disease: role of autoimmunity.
ACTA.TROP. 81 123-132 (2002).
 
2. SCHENKMAN, S., EICHINGER, D., PEREIRA, M.E. AND NUSSENZWEIG, V.
Structural and functional properties of Trypanosoma trans-sialidase.
ANNU.REV.MICROBIOL. 48 499-523 (1994).
 
3. KAHN, S., COLBERT, T.G., WALLACE, J.C., HOAGLAND, N.A. AND EISEN, H.
The major 85-kD surface antigen of the mammalian-stage forms of Trypanosoma 
cruzi is a family of sialidases.
PROC.NATL.ACAD.SCI.U.S.A. 88 4481-4485 (1991).
 
4. KAHN, S., VAN VOORHIS, W. AND EISEN, H. 
The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi 
is encoded by a large heterogeneous family of simultaneously expressed 
genes.
J.EXP.MED. 172 589-597 (1990).

Documentation
Trypanosoma cruzi is a kinetoplastid protozoan parasite of humans and other
animals, the causative agent of Chagas' disease [1]. It is transmitted via 
an insect vector, and exists as an intracellular form, the amastigote, or 
as a trypomastigote form in the blood after infection [1]. In the human 
host, chronic infection by T.cruzi affects the nervous system and heart, 
leading to various neurological disorders, damage to the heart muscle and 
eventually death [1]. 
 
The parasite expresses a variety of virulence factors in order to 
successfully invade the mammalian or insect host [2]. One of these is
unique to the genus Trypanosoma, a sialic acid-metabolising enzyme, dubbed
"trans-sialidase" [2,3], classified as a member of glycosyl hydrolase 
family 33. The protein catalyses the transfer of host cell sialic acids to 
acceptor receptors on the protozoan cell membrane, allowing the parasite to 
evade the immune response and enter the cell undetected [3]. It also acts as
the major 85kDa surface antigen of T.cruzi [3], and exhibits neuraminidase 
activity similar to that of some pathogenic viruses [3].
 
Research into the gene has revealed a massive diversity in the expression 
of this surface antigen/sialidase [4]. The variation in its amino acid 
sequences begs the question why such a successful parasite should need so 
many different versions of the same virulence factor [4]. 
 
TCSIALIDASE is a 10-element fingerprint that provides a signature for the 
Trypanosome sialidase family. The fingerprint was derived from an initial 
alignment of 11 sequences: the motifs were drawn from conserved regions 
spanning the C-terminal portion of the alignment - motifs 1-7 reside in the
Cys-rich domain and motifs 8-10 lie in the fibronectin type III domain. Two 
iterations on SPTR40_20f were required to reach convergence, at which point
a true set comprising 23 sequences was identified. Several partial matches
were also found, all of which are Trypanosoma spp. or bacterial sialidases
that failed to match 4 or more motifs. 
Summary Information
  23 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
4 codes involving 6 elements
0 codes involving 5 elements
2 codes involving 4 elements
2 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
1023232323232323232323
90000000000
80000000000
70000000000
63243323013
50000000000
42002020002
30020020002
22110000000
12345678910
True Positives
8511_TRYCR    GP85_TRYCR    O44049        O77209        
Q00773 Q08661 Q08672 Q26850
Q26851 Q26852 Q26853 Q26890
Q26963 Q26964 Q26966 Q26967
Q26968 Q26969 Q26971 Q27349
Q94798 Q9BHJ5 TCNA_TRYCR
True Positive Partials
Codes involving 6 elements
O76141 Q27064 Q9GSF0 Q9GU83
Codes involving 4 elements
O61081 O61082
Codes involving 3 elements
Q09060 Q26889
Codes involving 2 elements
NANH_CLOSO NANH_SALTY
Sequence Titles
8511_TRYCR  Sialidase 85-1.1 precursor (EC 3.2.1.18) (Neuraminidase) (NA) (Major 85 kDa surface antigen) (SA85-1.1 protein) - Trypanosoma cruzi. 
GP85_TRYCR 85 kDa surface antigen precursor - Trypanosoma cruzi.
O44049 SIALIDASE PRECURSOR (EC 3.2.1.18) (EXO-ALPHA-SIALIDASE) (NEURAMINIDASE) (N-ACYLNEURAMINATE GLYCOHYDROLASE) (ALPHA- NEURAMINIDASE) - Trypanosoma rangeli.
O77209 SURFACE GLYCOPROTEIN TC85-11 - Trypanosoma cruzi.
Q00773 SHED-ACUTE-PHASE-ANTIGEN - Trypanosoma cruzi.
Q08661 SURFACE GLYCOPROTEIN - Trypanosoma cruzi.
Q08672 LDG TRANS-SIALIDASE HOMOLOGUE - Trypanosoma rangeli.
Q26850 TRANS-SIALIDASE HOMOLOGUE - Trypanosoma cruzi.
Q26851 SURFACE GLYCOPROTEIN - Trypanosoma cruzi.
Q26852 SURFACE GLYCOPROTEIN - Trypanosoma cruzi.
Q26853 SURFACE GLYCOPROTEIN - Trypanosoma cruzi.
Q26890 SURFACE ANTIGEN - Trypanosoma cruzi.
Q26963 TRANS-SIALIDASE - Trypanosoma cruzi.
Q26964 TRANS-SIALIDASE - Trypanosoma cruzi.
Q26966 TRANS-SIALIDASE - Trypanosoma cruzi.
Q26967 TRANS-SIALIDASE - Trypanosoma cruzi.
Q26968 TRANS-SIALIDASE - Trypanosoma cruzi.
Q26969 TRANS-SIALIDASE - Trypanosoma cruzi.
Q26971 TRYPOMASTIGOTE SURFACE GLYCOPROTEIN PRECURSOR - Trypanosoma cruzi.
Q27349 85 KDA TRYPOMASTIGOTE SURFACE PROTEIN - Trypanosoma cruzi.
Q94798 SURFACE PROTEIN-1 - Trypanosoma cruzi.
Q9BHJ5 TRANS-SIALIDASE - Trypanosoma cruzi.
TCNA_TRYCR Sialidase (EC 3.2.1.18) (Neuraminidase) (NA) (Major surface antigen) - Trypanosoma cruzi.

O76141 SURFACE PROTEIN - Trypanosoma cruzi.
Q27064 SIALIDASE - Trypanosoma rangeli.
Q9GSF0 PUTATIVE TRANS-SIALIDASE B38P - Trypanosoma brucei.
Q9GU83 TSI1P - Trypanosoma brucei.

O61081 SIALIDASE HOMOLOG - Trypanosoma cruzi.
O61082 SIALIDASE HOMOLOG - Trypanosoma cruzi.

Q09060 FL-160-2 FLAGELLUM-ASSOCIATED PROTEIN PRECURSOR - Trypanosoma cruzi.
Q26889 COMPLEMENT REGULATORY PROTEIN - Trypanosoma cruzi.

NANH_CLOSO Sialidase precursor (EC 3.2.1.18) (Neuraminidase) - Clostridium sordellii.
NANH_SALTY Sialidase (EC 3.2.1.18) (Neuraminidase) (NANASE) (N-acylneuraminate glycohydrolase) (STNA) - Salmonella typhimurium.
Scan History
SPTR40_20f 2  50   NSINGLE    
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
FLGGAGVAIVASNGNLVY Q26969 176 176 -
FLGGGGSGIVMGNGTLVF Q26853 223 223 -
FLGGGGSGIVMGNGTLVF Q27349 224 224 -
FLGGGGSGIVMGNGTLVF Q26971 223 223 -
FLGGGGSGIVMGNGTLVF Q26852 223 223 -
FLGAGGSGIVMGNGTLVF Q08661 221 221 -
FLASGGSGVVMEDGTIVF 8511_TRYCR 240 240 -
FVASGGAGVLMEDGTIVF GP85_TRYCR 224 224 -
FYSSGGSGVVMEDGTIVF Q26890 58 58 -
CLASGGSGVLMEDGALVF O77209 243 243 -
LAPFGGAGVLMENGTLVF Q94798 217 217 -

Motif 2 width=19
Element Seqn Id St Int Rpt
DDGKTWKFGKGRSDFGCSE Q26969 213 19 -
DDGQKWEIPGGVSSVGCRS Q26853 260 19 -
DDGQKWEIPGGVSSVGCRS Q27349 261 19 -
DDGQKWEIPGGVSSVACRS Q26971 260 19 -
DDGQKWEIPGGVSSVACRS Q26852 260 19 -
DDGQKWEIPEVVSSVACHS Q08661 258 19 -
DNGSTWSLSEGISPAKCGA 8511_TRYCR 278 20 -
DDGSTWALSNSVSSAKCVN GP85_TRYCR 261 19 -
DDGANWMLSNGTPPAECLE Q26890 95 19 -
DNGSTWALSEDMSPANCTD O77209 281 20 -
DDGTNWVFPAGTPPAECVG Q94798 254 19 -

Motif 3 width=19
Element Seqn Id St Int Rpt
DYRRRLVYESSDMGNSWVE Q26969 248 16 -
CEDGRKVFESRDMGKTWTK Q26853 295 16 -
CEDGRKVFESRDMGKTWTK Q27349 295 15 -
CEDGRKVFESRDMGKTWTE Q26971 295 16 -
CEDGRKVFESRDMGKTWTE Q26852 295 16 -
CADGRKVFESRDMGKTWTK Q08661 293 16 -
CENDQRVYVSRDMGTTWTE 8511_TRYCR 312 15 -
CEDEQKVYVSRDMGTTWTE GP85_TRYCR 295 15 -
CVDGQRVYESRDMGTTWTE Q26890 129 15 -
CENEQRVYESCDMGKTWTE O77209 315 15 -
CTIGRKVYESRDMGTTWTE Q94798 289 16 -

Motif 4 width=15
Element Seqn Id St Int Rpt
AVTIEGMRVMLFTHP Q26969 292 25 -
TATIEGRKVMLYTQK Q26853 341 27 -
TATIEGRKVMLYTQK Q27349 341 27 -
TATIEGRKVMLYTQK Q26971 341 27 -
TATIEGRKVMLYTQK Q26852 341 27 -
TATIEGRKVMLYTQK Q08661 339 27 -
TVTIEGRKVMLYTQR 8511_TRYCR 358 27 -
TATIEGRRVMLYTQR GP85_TRYCR 342 28 -
AATIEGRKVMLYTQR Q26890 175 27 -
TASIEDRKVMLYTQR O77209 362 28 -
TATIEGVKVMLYTHK Q94798 336 28 -

Motif 5 width=18
Element Seqn Id St Int Rpt
YKDDKLYCLHEINSNEVY Q26969 348 41 -
YSDDGLYLSQQRGIQTST Q26853 400 44 -
YSDDGLYLSQQRGIQTST Q27349 400 44 -
YSDDALHLLQAKGDHEST Q26971 400 44 -
YSDDGLYLSQQRGIQTST Q26852 400 44 -
YSDDGLYLSQERGMRNST Q08661 398 44 -
YSDGGLHLLQRRDSGEDS 8511_TRYCR 417 44 -
YSDGKLHLLQRRVSGEGS GP85_TRYCR 399 42 -
YSDGSLHLLQRRANDKGS Q26890 233 43 -
YSDGKLHLLQRRGNSERS O77209 420 43 -
HSDGALHITRLTYTGAGT Q94798 395 44 -

Motif 6 width=20
Element Seqn Id St Int Rpt
RLVGELRIIKSVLQSWKNWD Q26969 371 5 -
RLTEELNTIKSVLSTWVQLD Q26853 423 5 -
RLTEELNTIKSVLSTWVQLD Q27349 423 5 -
RLTEELNTINSVLSTWVQLD Q26971 423 5 -
RLTEELNTIKSVLSTWVQLD Q26852 423 5 -
RLTEELNTIKSVLRTWAQLD Q08661 421 5 -
RLTEELKEIKSVLSTWSQKD 8511_TRYCR 440 5 -
RLTEELKEIESVLSTWAQKD GP85_TRYCR 422 5 -
RLTEELKTIKSVLSTWSKLD Q26890 256 5 -
RLTEELSTINSVLKTWAQND O77209 443 5 -
RLTRELETIKSTLSNWKKLD Q94798 418 5 -

Motif 7 width=19
Element Seqn Id St Int Rpt
DAYRCVNASMANAERVPNG Q26969 435 44 -
DGYRCMNATVTKAAKVENG Q26853 471 28 -
DGYRCMNATVTKAAKVENG Q27349 471 28 -
DGYRCMNATVTKAAKVENG Q26971 471 28 -
DGSSCMNATVTKAAKVENG Q26852 471 28 -
DGYRCLNATVTKASKVKNG Q08661 469 28 -
DEYLCLNATVTNATKVKDG 8511_TRYCR 487 27 -
DEYLCLNATVKNAVKVKDG GP85_TRYCR 469 27 -
DDYRSVNAKVMNAVKVHDG Q26890 303 27 -
DEYLCLNATVKNATKVKDG O77209 491 28 -
DDYGCVNANVTRATKVHNG Q94798 465 27 -

Motif 8 width=15
Element Seqn Id St Int Rpt
SYDEKHQWQPIYGST Q26969 518 64 -
SYGAGGKWETVYDGT Q26853 554 64 -
SYGAGGKWETVYDGT Q27349 554 64 -
SYGAGGKWETVYDGT Q26971 554 64 -
SYGAGGKWETVYDGT Q26852 554 64 -
SYGADGKWETLYDGT Q08661 552 64 -
SYTADNKWMTMLKDE 8511_TRYCR 570 64 -
SYTADNKWETIFKGD GP85_TRYCR 552 64 -
SYGTDGTWETVFNGE Q26890 384 62 -
SYTADNKWETMLKDE O77209 573 63 -
SYDANRNWETVFSAK Q94798 548 64 -

Motif 9 width=19
Element Seqn Id St Int Rpt
IGSVYIDGEPLEGSGQTVV Q26969 556 23 -
KGFVYVDGVLVGNPAMLPT Q26853 593 24 -
KGFVYVDGVLVGNPAMLPT Q27349 593 24 -
KGFVYVDGVLVGNPAMLPT Q26971 593 24 -
KGFVYVDGVLVGNPAMLPT Q26852 593 24 -
KGLVYVDGELVGSSAMLPI Q08661 591 24 -
KASVYVDGELLGEEEVPLT 8511_TRYCR 610 25 -
KASVYIDGRSLGEGEALLT GP85_TRYCR 592 25 -
KGSVYVDGMSVGSLATLPT Q26890 423 24 -
KRSVYVDGELLGEEEVPLT O77209 611 23 -
KGSVYVDAKLVGSPETLPT Q94798 587 24 -

Motif 10 width=16
Element Seqn Id St Int Rpt
TVNNVLLYNRQLNAEE Q26969 602 27 -
TLTDVFLYNRPLSVGE Q26853 636 24 -
TLTDVFLYNRPLSVGE Q27349 635 23 -
TLTDVFLYNRPLSVGE Q26971 636 24 -
TLTDVFLYNRPLSVGE Q26852 636 24 -
TVKDVFLYSRPLSADE Q08661 634 24 -
TVTNVFLYNRPLNSTE 8511_TRYCR 664 35 -
TVTNVFLYNRPLNSTE GP85_TRYCR 640 29 -
TVKNVFLYNRPLGADE Q26890 469 27 -
TVTNVFLYNRPLNSTE O77209 665 35 -
TVTNSFLYNRPLSEDE Q94798 630 24 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
FLGGAGVAIVASNGNLVY Q26963 207 207 -
FLGGAGVAIVASNGNLVY Q26968 176 176 -
FLGGAGVAIVASNGNLVY Q26967 176 176 -
FLGGAGVAIVASNGNLVY Q26969 176 176 -
FLGGAGVAIVASNGNLVY Q26964 207 207 -
FLGGAGVAIVASNGNLVY Q9BHJ5 177 177 -
FLGGAGVAIVASNGNLVY Q26966 176 176 -
FLGGAGVAIVASNGNLVY Q00773 207 207 -
FLGGAGVATVASNGNLVY Q26850 200 200 -
FLGGAGVAIVASNGNLVY TCNA_TRYCR 130 130 -
FLGGGGSGIVMGNGTLVF Q26851 221 221 -
FLGGGGSGIVMGNGTLVF Q26853 223 223 -
FLGGGGSGIVMGNGTLVF Q27349 224 224 -
FLGGGGSGIVMGNGTLVF Q26971 223 223 -
FLGGGGSGIVMGNGTLVF Q26852 223 223 -
FIGGVGAAIVGSNGNLVY O44049 198 198 -
FLGAGGSGIVMGNGTLVF Q08661 221 221 -
YLGGVGAAIVASNGNLVY Q08672 200 200 -
FLASGGSGVVMEDGTIVF 8511_TRYCR 240 240 -
FVASGGAGVLMEDGTIVF GP85_TRYCR 224 224 -
FYSSGGSGVVMEDGTIVF Q26890 58 58 -
CLASGGSGVLMEDGALVF O77209 243 243 -
LAPFGGAGVLMENGTLVF Q94798 217 217 -

Motif 2 width=19
Element Seqn Id St Int Rpt
DDGKTWKFGEGRSAFGCSE Q26963 244 19 -
DDGKTWKFGKGRSDFGCSE Q26968 213 19 -
DDGKTWKFGEGRSAFGCSE Q26967 213 19 -
DDGKTWKFGKGRSDFGCSE Q26969 213 19 -
DEGKTWKFGEGRSDFGCSE Q26964 244 19 -
DDGKTWKFGKGRSDFGCSE Q9BHJ5 214 19 -
DEGKTWKFGKGRSAFGCSE Q26966 213 19 -
DDGKTWKFGKGRSDFGCSE Q00773 244 19 -
DEGKTWNFSEGRSDFGCSE Q26850 237 19 -
DDGKTWKFGKGRSDFGCSE TCNA_TRYCR 167 19 -
DDGQKWEIPGGVSSVACRS Q26851 258 19 -
DDGQKWEIPGGVSSVGCRS Q26853 260 19 -
DDGQKWEIPGGVSSVGCRS Q27349 261 19 -
DDGQKWEIPGGVSSVACRS Q26971 260 19 -
DDGQKWEIPGGVSSVACRS Q26852 260 19 -
DDGNTWKFAEGRSKFGCSE O44049 235 19 -
DDGQKWEIPEVVSSVACHS Q08661 258 19 -
DDGNTWKFAEGRSKFGCSE Q08672 237 19 -
DNGSTWSLSEGISPAKCGA 8511_TRYCR 278 20 -
DDGSTWALSNSVSSAKCVN GP85_TRYCR 261 19 -
DDGANWMLSNGTPPAECLE Q26890 95 19 -
DNGSTWALSEDMSPANCTD O77209 281 20 -
DDGTNWVFPAGTPPAECVG Q94798 254 19 -

Motif 3 width=19
Element Seqn Id St Int Rpt
DYRRRLVYESSDMGNTWLE Q26963 279 16 -
DYRRRLVYESSDMGNSWVE Q26968 248 16 -
DYRRRLVYESSDMGNTWLE Q26967 248 16 -
DYRRRLVYESSDMGNSWVE Q26969 248 16 -
DYRRRLVYESSDMGNSWVE Q26964 279 16 -
DWKRRLVYESSDMGNTWVE Q9BHJ5 249 16 -
DYRRRLVYESSDMGNSWLE Q26966 248 16 -
DYRRRLVYESSDTEKPWVE Q00773 279 16 -
DYRRRLVYNSGDMKKPWVE Q26850 272 16 -
DWKRRLVYESSDMEKPWVE TCNA_TRYCR 202 16 -
CEDGRKVFESRDMGKTWTE Q26851 293 16 -
CEDGRKVFESRDMGKTWTK Q26853 295 16 -
CEDGRKVFESRDMGKTWTK Q27349 295 15 -
CEDGRKVFESRDMGKTWTE Q26971 295 16 -
CEDGRKVFESRDMGKTWTE Q26852 295 16 -
DGNRRLVYESSDMGKTWVE O44049 270 16 -
CADGRKVFESRDMGKTWTK Q08661 293 16 -
DGNRRLVYESSDMGKTWVE Q08672 272 16 -
CENDQRVYVSRDMGTTWTE 8511_TRYCR 312 15 -
CEDEQKVYVSRDMGTTWTE GP85_TRYCR 295 15 -
CVDGQRVYESRDMGTTWTE Q26890 129 15 -
CENEQRVYESCDMGKTWTE O77209 315 15 -
CTIGRKVYESRDMGTTWTE Q94798 289 16 -

Motif 4 width=15
Element Seqn Id St Int Rpt
AVTIEGMRVMLFTHP Q26963 323 25 -
AVTIEGMRVMLFTHP Q26968 292 25 -
AVTIEGMRVMLFTHP Q26967 292 25 -
AVTIEGMRVMLFTHP Q26969 292 25 -
AVTIEGMRVMLFTHP Q26964 323 25 -
AVTIEGMRVMLFTHP Q9BHJ5 293 25 -
AVTIEGMRVMLFTHP Q26966 292 25 -
AVTIEGMRVMLFTHP Q00773 323 25 -
AVTIEGMRVMLFTHP Q26850 316 25 -
AVTIEGMRVMLFTHP TCNA_TRYCR 246 25 -
TATIEGRKVMLYTQK Q26851 339 27 -
TATIEGRKVMLYTQK Q26853 341 27 -
TATIEGRKVMLYTQK Q27349 341 27 -
TATIEGRKVMLYTQK Q26971 341 27 -
TATIEGRKVMLYTQK Q26852 341 27 -
AVTIEGKRVMLFTHP O44049 314 25 -
TATIEGRKVMLYTQK Q08661 339 27 -
AATIEGKRVMLFTHP Q08672 316 25 -
TVTIEGRKVMLYTQR 8511_TRYCR 358 27 -
TATIEGRRVMLYTQR GP85_TRYCR 342 28 -
AATIEGRKVMLYTQR Q26890 175 27 -
TASIEDRKVMLYTQR O77209 362 28 -
TATIEGVKVMLYTHK Q94798 336 28 -

Motif 5 width=18
Element Seqn Id St Int Rpt
YKDDKLYCLHEINSNEVY Q26963 379 41 -
YKDDKLYCLHEINSNEVY Q26968 348 41 -
YKDDKLYCLHEINSNEVY Q26967 348 41 -
YKDDKLYCLHEINSNEVY Q26969 348 41 -
YKDDKLYCLHEINSNEVY Q26964 379 41 -
YKDDKLYCLHEINTDEVY Q9BHJ5 349 41 -
YKDDKLYCLHEINSNEVY Q26966 348 41 -
YKDDKLYCLHEINSNEVY Q00773 379 41 -
YKDDKLYCLHEINTNEVY Q26850 372 41 -
YKDDKLYCLHEINTDEVY TCNA_TRYCR 302 41 -
YSDDALHLLQAKGDHEST Q26851 398 44 -
YSDDGLYLSQQRGIQTST Q26853 400 44 -
YSDDGLYLSQQRGIQTST Q27349 400 44 -
YSDDALHLLQAKGDHEST Q26971 400 44 -
YSDDGLYLSQQRGIQTST Q26852 400 44 -
YKDDKLYSLHEINTNDVY O44049 370 41 -
YSDDGLYLSQERGMRNST Q08661 398 44 -
YKDDKLYCLHEVNVREVY Q08672 372 41 -
YSDGGLHLLQRRDSGEDS 8511_TRYCR 417 44 -
YSDGKLHLLQRRVSGEGS GP85_TRYCR 399 42 -
YSDGSLHLLQRRANDKGS Q26890 233 43 -
YSDGKLHLLQRRGNSERS O77209 420 43 -
HSDGALHITRLTYTGAGT Q94798 395 44 -

Motif 6 width=20
Element Seqn Id St Int Rpt
RLVGELRIIKSVLQSWKNWD Q26963 402 5 -
RLVGELRIIKSVLQSWKNWD Q26968 371 5 -
RLVGELRIIKSVLQSWKNWD Q26967 371 5 -
RLVGELRIIKSVLQSWKNWD Q26969 371 5 -
RLVGELRIIKSVLQSWKNWD Q26964 402 5 -
RLVGELRIIKSVLRSWKNWD Q9BHJ5 372 5 -
RLVGELRIIKSVLQSWKNWD Q26966 371 5 -
RLVGELRIIKSVLQSWKKWD Q00773 402 5 -
RLVGELMIIKSVLQSWKNWD Q26850 395 5 -
RLVGELRIIKSVLRSWKNWT TCNA_TRYCR 325 5 -
RLTEELNTIKSVLSTWVQLD Q26851 421 5 -
RLTEELNTIKSVLSTWVQLD Q26853 423 5 -
RLTEELNTIKSVLSTWVQLD Q27349 423 5 -
RLTEELNTINSVLSTWVQLD Q26971 423 5 -
RLTEELNTIKSVLSTWVQLD Q26852 423 5 -
RFIGELQLMKSVVRTWKEED O44049 393 5 -
RLTEELNTIKSVLRTWAQLD Q08661 421 5 -
RLVEELRLIRSVVGAWKEED Q08672 395 5 -
RLTEELKEIKSVLSTWSQKD 8511_TRYCR 440 5 -
RLTEELKEIESVLSTWAQKD GP85_TRYCR 422 5 -
RLTEELKTIKSVLSTWSKLD Q26890 256 5 -
RLTEELSTINSVLKTWAQND O77209 443 5 -
RLTRELETIKSTLSNWKKLD Q94798 418 5 -

Motif 7 width=19
Element Seqn Id St Int Rpt
DAYRCVNASTANAERVPNG Q26963 466 44 -
DAYRCVNASTANAERVPNG Q26968 435 44 -
DAYRCVNASTANAERVPNG Q26967 435 44 -
DAYRCVNASMANAERVPNG Q26969 435 44 -
DAYRCVNASTANAERVPNG Q26964 466 44 -
DAYRCVNASTANAERVRNG Q9BHJ5 436 44 -
DAYRCVNASTANAERVPNG Q26966 435 44 -
DAYRCVDASTANAERVSNG Q00773 466 44 -
DAYRCVNASTANAEKVPNG Q26850 459 44 -
GSYRCVNASTANAERVRNG TCNA_TRYCR 388 43 -
DGYRCMNATVTKAAKVENG Q26851 469 28 -
DGYRCMNATVTKAAKVENG Q26853 471 28 -
DGYRCMNATVTKAAKVENG Q27349 471 28 -
DGYRCMNATVTKAAKVENG Q26971 471 28 -
DGSSCMNATVTKAAKVENG Q26852 471 28 -
DVYRCVDANVANAERVPNG O44049 457 44 -
DGYRCLNATVTKASKVKNG Q08661 469 28 -
DVYRSVNATVMHGTNVTYG Q08672 459 44 -
DEYLCLNATVTNATKVKDG 8511_TRYCR 487 27 -
DEYLCLNATVKNAVKVKDG GP85_TRYCR 469 27 -
DDYRSVNAKVMNAVKVHDG Q26890 303 27 -
DEYLCLNATVKNATKVKDG O77209 491 28 -
DDYGCVNANVTRATKVHNG Q94798 465 27 -

Motif 8 width=15
Element Seqn Id St Int Rpt
SYDEKHQWQPIYGST Q26963 549 64 -
SYDEKHQWQPIYGST Q26968 518 64 -
SYDEKHQWQPIYGST Q26967 518 64 -
SYDEKHQWQPIYGST Q26969 518 64 -
SYDEKHQWQPIYGST Q26964 549 64 -
SYDEKHQWQPIYGST Q9BHJ5 519 64 -
SYDERHQWQPIYGST Q26966 518 64 -
SYDEKHQWQPIYGST Q00773 549 64 -
SYDEKHQWQPIYGST Q26850 542 64 -
SYDEKHQWQPIYGST TCNA_TRYCR 471 64 -
SYGAGGKWETVYDGT Q26851 552 64 -
SYGAGGKWETVYDGT Q26853 554 64 -
SYGAGGKWETVYDGT Q27349 554 64 -
SYGAGGKWETVYDGT Q26971 554 64 -
SYGAGGKWETVYDGT Q26852 554 64 -
SYDKNRQWRPLYGAA O44049 540 64 -
SYGADGKWETLYDGT Q08661 552 64 -
SYDKDQRWCPMYGPT Q08672 542 64 -
SYTADNKWMTMLKDE 8511_TRYCR 570 64 -
SYTADNKWETIFKGD GP85_TRYCR 552 64 -
SYGTDGTWETVFNGE Q26890 384 62 -
SYTADNKWETMLKDE O77209 573 63 -
SYDANRNWETVFSAK Q94798 548 64 -

Motif 9 width=19
Element Seqn Id St Int Rpt
IGSVYIDGEPLEGSGQTVV Q26963 587 23 -
IGSVYIDGEPLEGSGQTVV Q26968 556 23 -
IGSVYIDGEPLQGSGQTVV Q26967 556 23 -
IGSVYIDGEPLEGSGQTVV Q26969 556 23 -
IGSVYIDGEPLEGSGQTVV Q26964 587 23 -
IGSVYIDGELLEGSGQTVV Q9BHJ5 557 23 -
IGSEYIDGEPLEGSGQTVV Q26966 556 23 -
NGSVYVDGELLKGSGQTVV Q00773 587 23 -
MGSVYIDGVLLKGSGQTVV Q26850 580 23 -
IGSVYIDGELLEGSGQTVV TCNA_TRYCR 509 23 -
KGFVYVDGVLVGNPAMLPT Q26851 591 24 -
KGFVYVDGVLVGNPAMLPT Q26853 593 24 -
KGFVYVDGVLVGNPAMLPT Q27349 593 24 -
KGFVYVDGVLVGNPAMLPT Q26971 593 24 -
KGFVYVDGVLVGNPAMLPT Q26852 593 24 -
QGSVYVDGQPLAGSGNTVV O44049 578 23 -
KGLVYVDGELVGSSAMLPI Q08661 591 24 -
VGSIYIDGNLLKGSGQILS Q08672 580 23 -
KASVYVDGELLGEEEVPLT 8511_TRYCR 610 25 -
KASVYIDGRSLGEGEALLT GP85_TRYCR 592 25 -
KGSVYVDGMSVGSLATLPT Q26890 423 24 -
KRSVYVDGELLGEEEVPLT O77209 611 23 -
KGSVYVDAKLVGSPETLPT Q94798 587 24 -

Motif 10 width=16
Element Seqn Id St Int Rpt
TVNNVLLYNRQLNAEE Q26963 633 27 -
TVNNVLLYNRQLNAEE Q26968 602 27 -
TVNNVLLYNRQLNAEE Q26967 602 27 -
TVNNVLLYNRQLNAEE Q26969 602 27 -
TVNNVLLYNRQLNAEE Q26964 633 27 -
TVNNVLLYNRQLNTEE Q9BHJ5 603 27 -
TVNNVLLYNRQLNAEE Q26966 602 27 -
TVNNVLLYNRQLNAEE Q00773 632 26 -
TAKNVFLYNRQLNAKE Q26850 626 27 -
TVNNVLLYNRRQLNTE TCNA_TRYCR 555 27 -
TLTDVFLYNRPLSVGE Q26851 634 24 -
TLTDVFLYNRPLSVGE Q26853 636 24 -
TLTDVFLYNRPLSVGE Q27349 635 23 -
TLTDVFLYNRPLSVGE Q26971 636 24 -
TLTDVFLYNRPLSVGE Q26852 636 24 -
TVTNIVLYNRRLNSSE O44049 624 27 -
TVKDVFLYSRPLSADE Q08661 634 24 -
TVTNVMLYNRILKPNE Q08672 627 28 -
TVTNVFLYNRPLNSTE 8511_TRYCR 664 35 -
TVTNVFLYNRPLNSTE GP85_TRYCR 640 29 -
TVKNVFLYNRPLGADE Q26890 469 27 -
TVTNVFLYNRPLNSTE O77209 665 35 -
TVTNSFLYNRPLSEDE Q94798 630 24 -