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PR01772

Identifier
JNKMAPKINASE  [View Relations]  [View Alignment]  
Accession
PR01772
No. of Motifs
9
Creation Date
16-JUL-2002
Title
JNK MAP kinase signature
Database References

PFAM; PF03957 JNK
INTERPRO; IPR005643
PDB; 1JNK
SCOP; 1JNK
CATH; 1JNK
Literature References
1. LEWIS, T.S., SHAPIRO, P.S. AND AHN, N.G.
Signal transduction through kinase cascades. 
ADV.CANCER RES. 74 49-139 (1998).
 
2. ERREDE, B., CADE, R.M., YASHAR, B.M., KAMADA, Y., LEVIN, D.E., IRIE, K.
AND MATSUMOTO, K. 
Dynamics and organization of MAP kinases signal pathways. 
MOL.REPROD.DEV. 42 477-485 (1995).
 
3. KYRIAKIS, J.M. AND AVRUCH, J.
pp54 Microtubule-associated protein 2 kinas. A novel serine/threonine 
protein kinase regulated by phophorylation and stimulated by poly-L-lysine. 
J.BIOL.CHEM. 265 17355-17363 (1990).
 
4. HIBI, M., LIN, A., SMEAL, T., MINDEN, A. AND KARIN, M.
Identification of an oncoprotein and UV-responsive protein kinase that binds
and potentiates the c-Jun activation domain.
GENES DEV. 7 2135-2148 (1993).
 
5. SABAPATHY, K., JOCHUM, W., HOCHEDLINGER, K., CHANG, L. AND KARIN, M.
Defective neural tube morphogenesis and altered apoptosis in the absence of 
both JNK1 and JNK2.
MECH.DEV. 89 115-124 (1999).

Documentation
MAP (Mitogen Activated Protein) kinases participate in kinase cascades,  
whereby at least 3 protein kinases act in series, culminating in activation 
of MAP kinase [1-2]. MAP kinases are activated by dual phosphorylation 
on both tyrosine and threonine residues of a conserved TXY motif.
 
JNK (Jun N-terminal Kinase), also known as Stress Activated Protein Kinase 
(SAPK), belongs to the family of MAP kinases. JNK was first identified in 
1990 as a microtubule-associated kinase from livers of cycloheximide-treated
rats [3]. Later, it was purified by absorption to a c-Jun fusion protein 
[4]. JNKs are activated by cytokines, certain ligands for GPCRs, agents 
that interfere with DNA and protein synthesis, and to some extent by 
growth factors, serum and transforming agents. Three genes have been 
identified in humans: JNK1, JNK2 and JNK3. Knockouts of these genes have 
revealed that either JNK1 or JNK2 must have an anti-apoptotic role [5].
 
JNKMAPKINASE is a 9-element fingerprint that provides a signature for the 
JNK MAP kinases. The fingerprint was derived from an initial alignment of 9
sequences: the motifs were drawn from conserved regions spanning virtually 
the full alignment length, focusing on those sections that characterise the 
JNK enzymes but distinguish them from the rest of the MAP kinase family -
motif 1 includes the C-terminus of alpha-helix 2; motif 2 spans beta-strand
8, helix 3 and the N-terminus of helix 4; motif 3 encodes the C-terminus of
helix 4; motif 5 includes the N-terminus of helix 5; motif 6 includes the
C-terminal two-thirds of helix 8; motif 7 includes helix 11; motif 8
includes helix 12; and motif 9 spans the C-terminus of helix 14 and helix 15.
Two iterations on SPTR40_20f were required to reach convergence, at which 
point a true set comprising 18 sequences was identified. Several partial
matches were also found: O44408 and O44182 are hypothetical proteins from 
C.elegans that match 3 or 4 motifs; and Q9XXV1 is a MAP kinase related 
protein from Tetrahymena pyriformis that matches 2 motifs.
Summary Information
  18 codes involving  9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
1 codes involving 4 elements
1 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
9181818181818181818
8000000000
7000000000
6000000000
5000000000
4001011010
3001010010
2001001000
123456789
True Positives
MK08_HUMAN    MK08_RAT      MK09_HUMAN    MK09_MOUSE    
MK09_RAT MK10_HUMAN MK10_MOUSE MK10_RAT
O42099 P79996 P92208 Q17507
Q8VDD2 Q8WQG9 Q90327 Q91Y86
Q966Y3 Q9DGD9
True Positive Partials
Codes involving 4 elements
O44408
Codes involving 3 elements
O44182
Codes involving 2 elements
Q9XXV1
Sequence Titles
MK08_HUMAN  Mitogen-activated protein kinase 8 (EC 2.7.1.-) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46) - Homo sapiens (Human). 
MK08_RAT Mitogen-activated protein kinase 8 (EC 2.7.1.-) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (SAPK gamma) (p54 gamma) - Rattus norvegicus (Rat).
MK09_HUMAN Mitogen-activated protein kinase 9 (EC 2.7.1.-) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55) - Homo sapiens (Human).
MK09_MOUSE Mitogen-activated protein kinase 9 (EC 2.7.1.-) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) - Mus musculus (Mouse).
MK09_RAT Mitogen-activated protein kinase 9 (EC 2.7.1.-) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (SAPK-alpha) (p54- alpha) - Rattus norvegicus (Rat).
MK10_HUMAN Mitogen-activated protein kinase 10 (EC 2.7.1.-) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) - Homo sapiens (Human).
MK10_MOUSE Mitogen-activated protein kinase 10 (EC 2.7.1.-) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) - Mus musculus (Mouse).
MK10_RAT Mitogen-activated protein kinase 10 (EC 2.7.1.-) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (SAPK-beta) (p54- beta) - Rattus norvegicus (Rat).
O42099 JNKB - Cyprinus carpio (Common carp).
P79996 C-JUN AMINO-TERMINAL KINASE-2 ALPHA1 - Gallus gallus (Chicken).
P92208 STRESS-ACTIVATED PROTEIN KINASE JNK (EC 2.7.1.-) (C-JUN N-TERMINAL KINASE) (JNK PROTEIN KINASE) (BASKET PROTEIN) - Drosophila melanogaster (Fruit fly).
Q17507 HYPOTHETICAL 52.9 KDA PROTEIN (JNK-1) - Caenorhabditis elegans.
Q8VDD2 C-JUN N-TERMINAL KINASE - Mus musculus (Mouse).
Q8WQG9 HYPOTHETICAL 43.2 KDA PROTEIN - Caenorhabditis elegans.
Q90327 JNKA - Cyprinus carpio (Common carp).
Q91Y86 JNK1 - Mus musculus (Mouse).
Q966Y3 C-JUN N-TERMINAL KINASES (JNK) - Suberites domuncula (Sponge).
Q9DGD9 JNK1 - Brachydanio rerio (Zebrafish) (Zebra danio).

O44408 HYPOTHETICAL 45.2 KDA PROTEIN - Caenorhabditis elegans.

O44182 HYPOTHETICAL 43.4 KDA PROTEIN - Caenorhabditis elegans.

Q9XXV1 MAPK-RELATED KINASE - Tetrahymena pyriformis.
Scan History
SPTR40_20f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=10
Element Seqn Id St Int Rpt
LMKCVNHKNI MK10_HUMAN 114 114 -
LMKCVNHKNI MK10_MOUSE 114 114 -
LMKCVNHKNI MK08_HUMAN 76 76 -
LMKCVNHKNI MK08_RAT 76 76 -
LLKCVNHKNI MK09_HUMAN 76 76 -
LLKCVNHKNI MK09_MOUSE 76 76 -
LLKCVNHKNI MK09_RAT 76 76 -
LMKCVNHKNI MK10_RAT 114 114 -
LMKCVNHKNI Q9DGD9 76 76 -

Motif 2 width=16
Element Seqn Id St Int Rpt
DANLCQVIQMELDHER MK10_HUMAN 150 26 -
DANLCQVIQMELDHER MK10_MOUSE 150 26 -
DANLCQVIQMELDHER MK08_HUMAN 112 26 -
DANLCQVIQMELDHER MK08_RAT 112 26 -
DANLCQVIHMELDHER MK09_HUMAN 112 26 -
DANLCQVIHMELDHER MK09_MOUSE 112 26 -
DANLCQVIHMELDHER MK09_RAT 112 26 -
DANLCQVIQMELDHER MK10_RAT 150 26 -
DANLCQVIQMELDHER Q9DGD9 112 26 -

Motif 3 width=12
Element Seqn Id St Int Rpt
MLCGIKHLHSAG MK10_HUMAN 173 7 -
MLCGIKHLHSAG MK10_MOUSE 173 7 -
MLCGIKHLHSAG MK08_HUMAN 135 7 -
MLCGIKHLHSAG MK08_RAT 135 7 -
MLCGIKHLHSAG MK09_HUMAN 135 7 -
MLCGIKHLHSAG MK09_MOUSE 135 7 -
MLCGIKHLHSAG MK09_RAT 135 7 -
MLSAIKHLHSAG MK10_RAT 173 7 -
MLCGIKHLHAAG Q9DGD9 135 7 -

Motif 4 width=11
Element Seqn Id St Int Rpt
ARTAGTSFMMT MK10_HUMAN 211 26 -
ARTAGTSFMMT MK10_MOUSE 211 26 -
ARTAGTSFMMT MK08_HUMAN 173 26 -
ARTAGTSFMMT MK08_RAT 173 26 -
ARTACTNFMMT MK09_HUMAN 173 26 -
ARTACTNFMMT MK09_MOUSE 173 26 -
ARTACTNFMMT MK09_RAT 173 26 -
ARTAGTSFMMT MK10_RAT 211 26 -
ARTAATGLLMT Q9DGD9 173 26 -

Motif 5 width=11
Element Seqn Id St Int Rpt
LGMGYKENVDI MK10_HUMAN 236 14 -
LGMGYKENVDI MK10_MOUSE 236 14 -
LGMGYKENVDL MK08_HUMAN 198 14 -
LGMGYKENVDL MK08_RAT 198 14 -
LGMGYKENVDI MK09_HUMAN 198 14 -
LGMGYKENVDI MK09_MOUSE 198 14 -
LGMGYKENVDI MK09_RAT 198 14 -
LGMGYKENVDI MK10_RAT 236 14 -
LGMGYQANVDV Q9DGD9 198 14 -

Motif 6 width=13
Element Seqn Id St Int Rpt
QWNKVIEQLGTPC MK10_HUMAN 271 24 -
QWNKVIEQLGTPC MK10_MOUSE 271 24 -
QWNKVIEQLGTPC MK08_HUMAN 233 24 -
QWNKVIEQLGTPC MK08_RAT 233 24 -
QWNKVIEQLGTPS MK09_HUMAN 233 24 -
QWNKVIEQLGTPS MK09_MOUSE 233 24 -
QWNKVIEQLGTPS MK09_RAT 233 24 -
QWNKVIEQLGTPC MK10_RAT 271 24 -
QWNKVIEQLGTPS Q9DGD9 233 24 -

Motif 7 width=17
Element Seqn Id St Int Rpt
ENRPKYAGLTFPKLFPD MK10_HUMAN 299 15 -
ENRPKYAGLTFPKLFPD MK10_MOUSE 299 15 -
ENRPKYAGYSFEKLFPD MK08_HUMAN 261 15 -
ENRPKYAGYSFEKLFPD MK08_RAT 261 15 -
ENRPKYPGIKFEELFPD MK09_HUMAN 261 15 -
ENRPKYPGIKFEELFPD MK09_MOUSE 261 15 -
ENRPKYPGIKFEELFPD MK09_RAT 261 15 -
ENRPKYAGLTFPKLFPD MK10_RAT 299 15 -
ENRPRYAGYSFEKLFPD Q9DGD9 261 15 -

Motif 8 width=25
Element Seqn Id St Int Rpt
FPADSEHNKLKASQARDLLSKMLVI MK10_HUMAN 318 2 -
FPADSEHNKLKASQARDLLSKMLVI MK10_MOUSE 318 2 -
FPADSEHNKLKASQARDLLSKMLVI MK08_HUMAN 280 2 -
FPADSEHNKLKASQARDLLSKMLVI MK08_RAT 280 2 -
FPSESERDKIKTSQARDLLSKMLVI MK09_HUMAN 280 2 -
FPSESERDKIKTSQARDLLSKMLVI MK09_MOUSE 280 2 -
FPSESERDKIKTSQARDLLSKMLVI MK09_RAT 280 2 -
FPADSEHNKLKASQARDLLSKMLVI MK10_RAT 318 2 -
FPADSDHNKLKASQARDLLSKMLVI Q9DGD9 280 2 -

Motif 9 width=12
Element Seqn Id St Int Rpt
WYDPAEVEAPPP MK10_HUMAN 362 19 -
WYDPAEVEAPPP MK10_MOUSE 362 19 -
WYDPSEAEAPPP MK08_HUMAN 324 19 -
WYDPSEAEAPPP MK08_RAT 324 19 -
WYDPAEAEAPPP MK09_HUMAN 324 19 -
WYDPAEAEAPPP MK09_MOUSE 324 19 -
WYDPAEAEAPPP MK09_RAT 324 19 -
WYDPAEVEAPPP MK10_RAT 362 19 -
WYDPSEVEAPPP Q9DGD9 324 19 -
Final Motifs
Motif 1  width=10
Element Seqn Id St Int Rpt
LMKCVNHKNI MK10_HUMAN 114 114 -
LMKCVNHKNI MK10_MOUSE 114 114 -
LMKCVNHKNI MK08_HUMAN 76 76 -
LMKCVNHKNI MK08_RAT 76 76 -
LMKCVNHKNI Q91Y86 76 76 -
LLKCVNHKNI MK09_HUMAN 76 76 -
LLKCVNHKNI MK09_MOUSE 76 76 -
LLKCVNHKNI MK09_RAT 76 76 -
LMKCVNHKNI MK10_RAT 114 114 -
LLKCVNHKNI P79996 76 76 -
LLKCVNHKNI Q8VDD2 76 76 -
LMKYVNHKNI Q90327 76 76 -
LMKCVNHKNI O42099 76 76 -
LMKCVNHKNI Q9DGD9 76 76 -
LMKLVNHKNI P92208 74 74 -
LMSLVNHKNI Q17507 169 169 -
LMSLVNHKNI Q8WQG9 78 78 -
LMKMVDHKNI Q966Y3 72 72 -

Motif 2 width=16
Element Seqn Id St Int Rpt
DANLCQVIQMELDHER MK10_HUMAN 150 26 -
DANLCQVIQMELDHER MK10_MOUSE 150 26 -
DANLCQVIQMELDHER MK08_HUMAN 112 26 -
DANLCQVIQMELDHER MK08_RAT 112 26 -
DANLCQVIQMELDHER Q91Y86 112 26 -
DANLCQVIHMELDHER MK09_HUMAN 112 26 -
DANLCQVIHMELDHER MK09_MOUSE 112 26 -
DANLCQVIHMELDHER MK09_RAT 112 26 -
DANLCQVIQMELDHER MK10_RAT 150 26 -
DANLCQVIHMELDHER P79996 112 26 -
DANLCQVIHMELDHER Q8VDD2 112 26 -
DANLCQVIQMELDHER Q90327 112 26 -
DANLCQVIQMELDHER O42099 112 26 -
DANLCQVIQMELDHER Q9DGD9 112 26 -
DANLCQVIQMDLDHDR P92208 110 26 -
DANLCQVIQMDLDHER Q17507 205 26 -
DANLCQVIQMDLDHER Q8WQG9 114 26 -
DANLCRVIGIELDHDR Q966Y3 108 26 -

Motif 3 width=12
Element Seqn Id St Int Rpt
MLCGIKHLHSAG MK10_HUMAN 173 7 -
MLCGIKHLHSAG MK10_MOUSE 173 7 -
MLCGIKHLHSAG MK08_HUMAN 135 7 -
MLCGIKHLHSAG MK08_RAT 135 7 -
MLCGIKHLHSAG Q91Y86 135 7 -
MLCGIKHLHSAG MK09_HUMAN 135 7 -
MLCGIKHLHSAG MK09_MOUSE 135 7 -
MLCGIKHLHSAG MK09_RAT 135 7 -
MLSAIKHLHSAG MK10_RAT 173 7 -
MLCGIKHLHSAG P79996 135 7 -
MLCGIKHLHSAG Q8VDD2 135 7 -
MLCGIKHLHSAG Q90327 135 7 -
MLCGTKHLHSAG O42099 135 7 -
MLCGIKHLHAAG Q9DGD9 135 7 -
MLCGIKHLHSAG P92208 133 7 -
MLCGIRHLHSAG Q17507 228 7 -
MLCGIRHLHSAG Q8WQG9 137 7 -
LLCGIKHLHSAG Q966Y3 131 7 -

Motif 4 width=11
Element Seqn Id St Int Rpt
ARTAGTSFMMT MK10_HUMAN 211 26 -
ARTAGTSFMMT MK10_MOUSE 211 26 -
ARTAGTSFMMT MK08_HUMAN 173 26 -
ARTAGTSFMMT MK08_RAT 173 26 -
ARTAGTSFMMT Q91Y86 173 26 -
ARTACTNFMMT MK09_HUMAN 173 26 -
ARTACTNFMMT MK09_MOUSE 173 26 -
ARTACTNFMMT MK09_RAT 173 26 -
ARTAGTSFMMT MK10_RAT 211 26 -
ARTACTNFMMT P79996 173 26 -
ARTACTNFMMT Q8VDD2 173 26 -
ARTAATGLLMT Q90327 173 26 -
ARTAATGLLMT O42099 173 26 -
ARTAATGLLMT Q9DGD9 173 26 -
ARTAGTTFMMT P92208 171 26 -
ARTAIEAFMMT Q17507 266 26 -
ARTAIEAFMMT Q8WQG9 175 26 -
ARTADQTFNMT Q966Y3 169 26 -

Motif 5 width=11
Element Seqn Id St Int Rpt
LGMGYKENVDI MK10_HUMAN 236 14 -
LGMGYKENVDI MK10_MOUSE 236 14 -
LGMGYKENVDL MK08_HUMAN 198 14 -
LGMGYKENVDL MK08_RAT 198 14 -
LGMGYKENVDL Q91Y86 198 14 -
LGMGYKENVDI MK09_HUMAN 198 14 -
LGMGYKENVDI MK09_MOUSE 198 14 -
LGMGYKENVDI MK09_RAT 198 14 -
LGMGYKENVDI MK10_RAT 236 14 -
LGMGYKENVDI P79996 198 14 -
LGMGYKENVDI Q8VDD2 198 14 -
LGMGYQANVDI Q90327 198 14 -
LGMGYQANVDV O42099 198 14 -
LGMGYQANVDV Q9DGD9 198 14 -
LGMGYTENVDI P92208 196 14 -
LGMGYKENVDV Q17507 291 14 -
LGMGYKENVDV Q8WQG9 200 14 -
VGMKYKENVDI Q966Y3 194 14 -

Motif 6 width=13
Element Seqn Id St Int Rpt
QWNKVIEQLGTPC MK10_HUMAN 271 24 -
QWNKVIEQLGTPC MK10_MOUSE 271 24 -
QWNKVIEQLGTPC MK08_HUMAN 233 24 -
QWNKVIEQLGTPC MK08_RAT 233 24 -
QWNKVIEQLGTPC Q91Y86 233 24 -
QWNKVIEQLGTPS MK09_HUMAN 233 24 -
QWNKVIEQLGTPS MK09_MOUSE 233 24 -
QWNKVIEQLGTPS MK09_RAT 233 24 -
QWNKVIEQLGTPC MK10_RAT 271 24 -
QWNKVIEQLGTPS P79996 233 24 -
QWNKAIEQLGTPS Q8VDD2 257 48 -
QWNKVIEQLGTPT Q90327 233 24 -
QWNKVIEQLGTPS O42099 233 24 -
QWNKVIEQLGTPS Q9DGD9 233 24 -
QWNKIIEQLGTPS P92208 231 24 -
QWTRIIEQLGTPD Q17507 326 24 -
QWTRIIEQLGTPD Q8WQG9 235 24 -
QWNKVTQVLGTPP Q966Y3 229 24 -

Motif 7 width=17
Element Seqn Id St Int Rpt
ENRPKYAGLTFPKLFPD MK10_HUMAN 299 15 -
ENRPKYAGLTFPKLFPD MK10_MOUSE 299 15 -
ENRPKYAGYSFEKLFPD MK08_HUMAN 261 15 -
ENRPKYAGYSFEKLFPD MK08_RAT 261 15 -
ENRPKYAGYSFEKLFPD Q91Y86 261 15 -
ENRPKYPGIKFEELFPD MK09_HUMAN 261 15 -
ENRPKYPGIKFEELFPD MK09_MOUSE 261 15 -
ENRPKYPGIKFEELFPD MK09_RAT 261 15 -
ENRPKYAGLTFPKLFPD MK10_RAT 299 15 -
ENRPKYPGIKFEELFPD P79996 261 15 -
ENRPKYPGIKFEELFPD Q8VDD2 285 15 -
ENRPRYTGYSFEKLFPD Q90327 261 15 -
ENRPRYTGYSFEKLFPD O42099 261 15 -
ENRPRYAGYSFEKLFPD Q9DGD9 261 15 -
ENRPRYTGYSFDRLFPD P92208 259 15 -
ENRPRYQATPFEVLFSD Q17507 354 15 -
ENRPRYQATPFEVLFSD Q8WQG9 263 15 -
ESQPRYAGKSWKDLFPD Q966Y3 257 15 -

Motif 8 width=25
Element Seqn Id St Int Rpt
FPADSEHNKLKASQARDLLSKMLVI MK10_HUMAN 318 2 -
FPADSEHNKLKASQARDLLSKMLVI MK10_MOUSE 318 2 -
FPADSEHNKLKASQARDLLSKMLVI MK08_HUMAN 280 2 -
FPADSEHNKLKASQARDLLSKMLVI MK08_RAT 280 2 -
FPADSEHNKLKASQARDLLSKMLVI Q91Y86 280 2 -
FPSESERDKIKTSQARDLLSKMLVI MK09_HUMAN 280 2 -
FPSESERDKIKTSQARDLLSKMLVI MK09_MOUSE 280 2 -
FPSESERDKIKTSQARDLLSKMLVI MK09_RAT 280 2 -
FPADSEHNKLKASQARDLLSKMLVI MK10_RAT 318 2 -
FPSESDRDKLKTSQARDLLSKMLVV P79996 280 2 -
FPSESERDKIKTSQARDLLSKMLVI Q8VDD2 304 2 -
FPADSEHNKLKASQARDLLSKMLVI Q90327 280 2 -
FPADSEHNKLKASQARDLLSKMLVI O42099 280 2 -
FPADSDHNKLKASQARDLLSKMLVI Q9DGD9 280 2 -
PNDNNQNSRRKASDARNLLSKMLVI P92208 279 3 -
FPMTADSSRLTGAQARDLLSRMLVI Q17507 373 2 -
FPMTADSSRLTGAQARDLLSRMLVI Q8WQG9 282 2 -
FPNDTPEDKAKTRHGRDLLSKMLQI Q966Y3 276 2 -

Motif 9 width=12
Element Seqn Id St Int Rpt
WYDPAEVEAPPP MK10_HUMAN 362 19 -
WYDPAEVEAPPP MK10_MOUSE 362 19 -
WYDPSEAEAPPP MK08_HUMAN 324 19 -
WYDPSEAEAPPP MK08_RAT 324 19 -
WYDPSEAEAPPP Q91Y86 324 19 -
WYDPAEAEAPPP MK09_HUMAN 324 19 -
WYDPAEAEAPPP MK09_MOUSE 324 19 -
WYDPAEAEAPPP MK09_RAT 324 19 -
WYDPAEVEAPPP MK10_RAT 362 19 -
WYDPAEAEAPPP P79996 324 19 -
WYDPAEAEAPPP Q8VDD2 348 19 -
WYDPAEVEAPPP Q90327 324 19 -
WYDPAEVEAPPP O42099 324 19 -
WYDPSEVEAPPP Q9DGD9 324 19 -
WYDAEEVDAPAP P92208 323 19 -
WFDEIEVYAPPP Q17507 417 19 -
WFDEIEVYAPPP Q8WQG9 326 19 -
WYDPAEVHAPPP Q966Y3 320 19 -