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PR01610

Identifier
CD36ANTIGEN  [View Relations]  [View Alignment]  
Accession
PR01610
No. of Motifs
13
Creation Date
23-DEC-2001
Title
Adhesion molecule CD36 signature
Database References
PRINTS; PR01609 CD36FAMILY
MIM; 173510
Literature References
1. OKUMURA, T. AND JAMIESON, G.A.
Platelet glycocalicin. Orientation of glycoproteins on the human platelet
surface.
J.BIOL.CHEM. 251 5944-5949 (1976).
 
2. NICHOLSON, A.C., FEBBRAIO, M.,  HAN, J., SILVERSTEIN, R.L. AND
HAJJAR, D.P.
CD36 in atherosclerosis. The role of a class B macrophage scavenger receptor.
ANN.N.Y.ACAD.SCI. 902 128-131 (2000).
 
3. SILVERSTEIN, R.L. AND FEBBRAIO, M.
CD36 and atherosclerosis.
CURR.OPIN.LIPIDOL. 11 483-491 (2000). 
 
4. SAVILL, J., HOGG, N., REN, Y. AND HASLETT, C.
Thrombospondin cooperates with CD36 and the vitronectin receptor
in macrophage recognition of neutrophils undergoing apoptosis. 
J.CLIN.INVEST. 90 1513-1522 (1989).
 
5. TANDON, NN., KRALISZ, U. AND JAMIESON, GA.
Identification of glycoprotein IV (CD36) as a primary receptor 
for platelet-collagen adhesion.
J.BIOL.CHEM. 264 7576-7583 (1989).
 
6. MCGREGOR, J.L., CATIMEL, B., PARMENTIER, S., CLEZARDIN, P., DECHAVANNE, M. 
AND LEUNG, L.L.
Rapid purification and partial characterization of human platelet
glycoprotein IIIb. Interaction with thrombospondin and its role in platelet 
aggregation.
J.BIOL.CHEM. 264 501-506 (1989).
 
7. BARNWELL, J.W., ASCH, A.S., NACHMAN, R.L., YAMAYA, M., AIKAWA, M. AND
INGRAVALLO, P.
A human 88-KD membrane glycoprotein (CD36) functions in vitro as a receptor
for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes.
J.CLIN.INVEST. 84 765-772 (1989).
 
8. BULL, H.A., BRICKELL, P.M. AND DOWD, P.M.
Src-related protein tyrosine kinases are physically associated with the 
surface antigen CD36 in human dermal microvascular endothelial cells.
FEBS LETT. 351 41-44 (1994).
 
9. MIYAOKA, K., KUWASAKO, T., HIRANO, K., NOZAKI, S., YAMASHITA, S. 
AND MATSUZAWA, Y.
CD36 deficiency associated with insulin resistance.
LANCET 357 686-687 (2001).

Documentation
CD36 is a transmembrane, highly glycosylated, 88kDa glycoprotein [1] 
expressed by monocytes, macrophages, platelets, microvascular endothelial 
cells and adipose tissue [2]. It is a multifunctional receptor that binds
to oxidised LDL (OxLDL), long chain fatty acids, anionic phospholipids,
apoptotic cells, thrombospondin (TSP), collagen and Plasmodium falciparum-
infected erythrocytes [2].
 
CD36 has numerous cellular functions. It is a type B scavenger receptor, 
playing a major role in the uptake of OxLDL by macrophages [3]. The lipid-
rich macrophages are then differentiated into foam cells and contribute to
the formation of atherosclerotic lesions [3]. In addition, CD36 of macro-
phages, together with TSP and the integrin alphav beta3, can phagocytose
apoptotic neutrophils [4]. Furthermore, the protein is one of the receptors
of collagen in platelet adhesion and aggregation [5,6]. CD36 can also
mediate cytoadherence of Plasmodium falciparum-infected erythrocytes to the
endothelium of post-capillary venules of different organs [7]. Moreover,
cytoplasmic CD36 plays an important role in signal transduction by inter-
acting with Src family tyrosine kinases [8]. Deficiency in CD36 in Asian
and African populations has been associated with insulin resistance [9]. 
 
CD36 is a 13-element fingerprint that provides a signature for the CD36
adhesion molecules. The fingerprint was derived from an initial alignment
of 4 sequences, focusing on those sections that characterise CD36 adhesion 
molecules but distinguish them from the rest of the CD36 family: motif 1
spans the first putative, N-terminal TM domain; motifs 2-12 reside in the
extracellular domain; and motif 13 spans the second putative, C-terminal 
TM domain. Two iterations on SPTR40_18f were required to reach convergence, 
at which point a true set comprising 6 sequences was identified.
Summary Information
6 codes involving 13 elements
0 codes involving 12 elements
0 codes involving 11 elements
0 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
136666666666666
120000000000000
110000000000000
100000000000000
90000000000000
80000000000000
70000000000000
60000000000000
50000000000000
40000000000000
30000000000000
20000000000000
12345678910111213
True Positives
CD36_BOVIN    CD36_HUMAN    CD36_MESAU    CD36_MOUSE    
CD36_RAT O35754
Sequence Titles
CD36_BOVIN  Platelet glycoprotein IV (GPIV) (GPIIIB) (CD36 antigen) (PAS IV) (PAS-4 protein) - Bos taurus (Bovine). 
CD36_HUMAN Platelet glycoprotein IV (GPIV) (GPIIIB) (CD36 antigen) (PAS IV) (PAS-4 protein) - Homo sapiens (Human).
CD36_MESAU Platelet glycoprotein IV (GPIV) (GPIIIB) (CD36 antigen) (PAS IV) (PAS-4 protein) - Mesocricetus auratus (Golden hamster).
CD36_MOUSE Platelet glycoprotein IV (GPIV) (GPIIIB) (CD36 antigen) (PAS IV) (PAS-4 protein) - Mus musculus (Mouse).
CD36_RAT Platelet glycoprotein IV (GPIV) (GPIIIB) (CD36 antigen) (PAS IV) (PAS- 4 protein) (Fatty acid transport protein) (Fatty acid translocase) (Adipocyte membrane protein) - Rattus norvegicus (Rat).
O35754 FATTY ACID TRANSPORT PROTEIN (FATTY ACID TRANSPORTER) - Rattus norvegicus (Rat).
Scan History
SPTR40_18f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=22
Element Seqn Id St Int Rpt
CDRNCGLITGAVIGAVLAVFGG CD36_RAT 2 2 -
CDRNCGLIAGAVIGAVLAVFGG CD36_MOUSE 2 2 -
CNRNCGLIAGAVIGAVLAVFGG CD36_BOVIN 2 2 -
CDRNCGLIAGAVIGAVLAVFGG CD36_HUMAN 2 2 -

Motif 2 width=23
Element Seqn Id St Int Rpt
ILMPVGDLLIEKTIKREVVLEEG CD36_RAT 24 0 -
ILMPVGDMLIEKTIKREVVLEEG CD36_MOUSE 24 0 -
ILMPVGDMLIEKTIKKEVVLEEG CD36_BOVIN 24 0 -
ILMPVGDLLIQKTIKKQVVLEEG CD36_HUMAN 24 0 -

Motif 3 width=23
Element Seqn Id St Int Rpt
WVFDVQNPEEVAKNSSKIKVIQR CD36_RAT 65 18 -
WIFDVQNPDDVAKNSSKIKVKQR CD36_MOUSE 65 18 -
WIFDVQNPDEVTVNSSKIKVKQR CD36_BOVIN 65 18 -
WIFDVQNPQEVMMNSSNIQVKQR CD36_HUMAN 65 18 -

Motif 4 width=20
Element Seqn Id St Int Rpt
VRYLAKENITQDPKDSTVSF CD36_RAT 94 6 -
VRYLAKENITQDPEDHTVSF CD36_MOUSE 94 6 -
VRYLAKENITQDPETNTVSF CD36_BOVIN 94 6 -
VRFLAKENVTQDAEDNTVSF CD36_HUMAN 94 6 -

Motif 5 width=21
Element Seqn Id St Int Rpt
GTENDNFTVLNLAVAAAPHIY CD36_RAT 128 14 -
GTEDDNFTVLNLAVAAAPHIY CD36_MOUSE 128 14 -
GTEDDKFTILNLAVAAAPQLY CD36_BOVIN 128 14 -
GTEADNFTVLNLAVAAASHIY CD36_HUMAN 128 14 -

Motif 6 width=22
Element Seqn Id St Int Rpt
YTNSFVQGVLNSLIKKSKSSMF CD36_RAT 148 -1 -
YQNSFVQVVLNSLIKKSKSSMF CD36_MOUSE 148 -1 -
YPNTFMQGILNSFIKKSKSSMF CD36_BOVIN 148 -1 -
YQNQFVQMILNSLINKSKSSMF CD36_HUMAN 148 -1 -

Motif 7 width=17
Element Seqn Id St Int Rpt
PYPISTTVGVFYPYNNT CD36_RAT 190 20 -
PYPISTTVGVFYPYNDT CD36_MOUSE 190 20 -
PYPITTTIGVFYPYNNT CD36_BOVIN 190 20 -
PYPVTTTVGLFYPYNNT CD36_HUMAN 190 20 -

Motif 8 width=15
Element Seqn Id St Int Rpt
KRNLSYWESYCDMIN CD36_RAT 232 25 -
KRNLSYWPSYCDMIN CD36_MOUSE 232 25 -
RKNLSYWSSYCDLIN CD36_BOVIN 232 25 -
KRNLSYWESHCDMIN CD36_HUMAN 232 25 -

Motif 9 width=23
Element Seqn Id St Int Rpt
FASPLQNPDNHCFCTEKVISNNC CD36_RAT 299 52 -
FASPLQNPDNHCFCTEKVISNNC CD36_MOUSE 299 52 -
FASPFENPDNHCFCTEKIISKNC CD36_BOVIN 299 52 -
FASPVENPDNYCFCTEKIISKNC CD36_HUMAN 299 52 -

Motif 10 width=19
Element Seqn Id St Int Rpt
FLHASPDVSEPIEGLNPTE CD36_RAT 345 23 -
FLHASPDVSEPIEGLHPNE CD36_MOUSE 345 23 -
FLHGSPELAEPIEGLSPNE CD36_BOVIN 345 23 -
FLYASPDVSEPIDGLNPNE CD36_HUMAN 345 23 -

Motif 11 width=15
Element Seqn Id St Int Rpt
KIEALKNLKRPYIVP CD36_RAT 397 33 -
KIEALKNLKRPYIVP CD36_MOUSE 397 33 -
KIEALKNLKHNYIVP CD36_BOVIN 397 33 -
KIQVLKNLKRNYIVP CD36_HUMAN 397 33 -

Motif 12 width=19
Element Seqn Id St Int Rpt
TGTIGDEKAEMFRNQVTGK CD36_RAT 418 6 -
TGTIGDEKAEMFKTQVTGK CD36_MOUSE 418 6 -
TGTIGDEKAEMFRNQVTGK CD36_BOVIN 418 6 -
TGTIGDEKANMFRSQVTGK CD36_HUMAN 418 6 -

Motif 13 width=23
Element Seqn Id St Int Rpt
KIKLLGLVEMVLLGVGVVMFVAF CD36_RAT 436 -1 -
KIKLLGMVEMALLGIGVVMFVAF CD36_MOUSE 436 -1 -
KINLLGLVEIVLLSVGVVMFIAF CD36_BOVIN 436 -1 -
KINLLGLIEMILLSVGVVMFVAF CD36_HUMAN 436 -1 -
Final Motifs
Motif 1  width=22
Element Seqn Id St Int Rpt
CDRNCGLITGAVIGAVLAVFGG CD36_RAT 2 2 -
CDRNCGLIAGAVIGAVLAVFGG CD36_MOUSE 2 2 -
CNRNCGLIAGAVIGAVLAVFGG CD36_BOVIN 2 2 -
CDRNCGLIAGAVIGAVLAVFGG CD36_HUMAN 2 2 -
CDRNCGLIAGAVIGAVLAVFGG CD36_MESAU 2 2 -
CDRNCGLITGAVIGAVLAVFGG O35754 3 3 -

Motif 2 width=23
Element Seqn Id St Int Rpt
ILMPVGDLLIEKTIKREVVLEEG CD36_RAT 24 0 -
ILMPVGDMLIEKTIKREVVLEEG CD36_MOUSE 24 0 -
ILMPVGDMLIEKTIKKEVVLEEG CD36_BOVIN 24 0 -
ILMPVGDLLIQKTIKKQVVLEEG CD36_HUMAN 24 0 -
ILMPVGDMLVEKTIKKEVVLEEG CD36_MESAU 24 0 -
ILMPVGDLLIEKTIKREVVLEEG O35754 25 0 -

Motif 3 width=23
Element Seqn Id St Int Rpt
WVFDVQNPEEVAKNSSKIKVIQR CD36_RAT 65 18 -
WIFDVQNPDDVAKNSSKIKVKQR CD36_MOUSE 65 18 -
WIFDVQNPDEVTVNSSKIKVKQR CD36_BOVIN 65 18 -
WIFDVQNPQEVMMNSSNIQVKQR CD36_HUMAN 65 18 -
WIFDVQNPDEVAVNSSKIKVKQR CD36_MESAU 65 18 -
WIFDVQNPEEVAKNSSKIKVKQR O35754 66 18 -

Motif 4 width=20
Element Seqn Id St Int Rpt
VRYLAKENITQDPKDSTVSF CD36_RAT 94 6 -
VRYLAKENITQDPEDHTVSF CD36_MOUSE 94 6 -
VRYLAKENITQDPETNTVSF CD36_BOVIN 94 6 -
VRFLAKENVTQDAEDNTVSF CD36_HUMAN 94 6 -
VRYLAKENITQDPVDSTVSF CD36_MESAU 94 6 -
VRYLAKESITQDPKDSTVSF O35754 95 6 -

Motif 5 width=21
Element Seqn Id St Int Rpt
GTENDNFTVLNLAVAAAPHIY CD36_RAT 128 14 -
GTEDDNFTVLNLAVAAAPHIY CD36_MOUSE 128 14 -
GTEDDKFTILNLAVAAAPQLY CD36_BOVIN 128 14 -
GTEADNFTVLNLAVAAASHIY CD36_HUMAN 128 14 -
GTENDTFTILNLAVAAAPHIY CD36_MESAU 128 14 -
GTENDNFTVLNLAVAAVPHIY O35754 129 14 -

Motif 6 width=22
Element Seqn Id St Int Rpt
YTNSFVQGVLNSLIKKSKSSMF CD36_RAT 148 -1 -
YQNSFVQVVLNSLIKKSKSSMF CD36_MOUSE 148 -1 -
YPNTFMQGILNSFIKKSKSSMF CD36_BOVIN 148 -1 -
YQNQFVQMILNSLINKSKSSMF CD36_HUMAN 148 -1 -
YTNSFVQVVLNSLIKKSKSSMF CD36_MESAU 148 -1 -
YQNSFFQGVLNIFIKKSKXSXX O35754 149 -1 -

Motif 7 width=17
Element Seqn Id St Int Rpt
PYPISTTVGVFYPYNNT CD36_RAT 190 20 -
PYPISTTVGVFYPYNDT CD36_MOUSE 190 20 -
PYPITTTIGVFYPYNNT CD36_BOVIN 190 20 -
PYPVTTTVGLFYPYNNT CD36_HUMAN 190 20 -
PYPIPTTVGVFYPYNDT CD36_MESAU 190 20 -
PYPISTTVGVFYPYNNT O35754 191 20 -

Motif 8 width=15
Element Seqn Id St Int Rpt
KRNLSYWESYCDMIN CD36_RAT 232 25 -
KRNLSYWPSYCDMIN CD36_MOUSE 232 25 -
RKNLSYWSSYCDLIN CD36_BOVIN 232 25 -
KRNLSYWESHCDMIN CD36_HUMAN 232 25 -
KRNLSYWESYCDMIN CD36_MESAU 232 25 -
KRNLSYWKSYCDMIN O35754 233 25 -

Motif 9 width=23
Element Seqn Id St Int Rpt
FASPLQNPDNHCFCTEKVISNNC CD36_RAT 299 52 -
FASPLQNPDNHCFCTEKVISNNC CD36_MOUSE 299 52 -
FASPFENPDNHCFCTEKIISKNC CD36_BOVIN 299 52 -
FASPVENPDNYCFCTEKIISKNC CD36_HUMAN 299 52 -
FASPVQNPDNHCFCTEKVISNNC CD36_MESAU 299 52 -
FASPLQNPDNHCFCTEKVISNNC O35754 300 52 -

Motif 10 width=19
Element Seqn Id St Int Rpt
FLHASPDVSEPIEGLNPTE CD36_RAT 345 23 -
FLHASPDVSEPIEGLHPNE CD36_MOUSE 345 23 -
FLHGSPELAEPIEGLSPNE CD36_BOVIN 345 23 -
FLYASPDVSEPIDGLNPNE CD36_HUMAN 345 23 -
FLHASPDISEPIEGLNPNE CD36_MESAU 345 23 -
FLHASPDVSEPIEGLNPNE O35754 346 23 -

Motif 11 width=15
Element Seqn Id St Int Rpt
KIEALKNLKRPYIVP CD36_RAT 397 33 -
KIEALKNLKRPYIVP CD36_MOUSE 397 33 -
KIEALKNLKHNYIVP CD36_BOVIN 397 33 -
KIQVLKNLKRNYIVP CD36_HUMAN 397 33 -
KIEALKNLKRNYIVP CD36_MESAU 397 33 -
KIEPLKNLKRPYIVP O35754 398 33 -

Motif 12 width=19
Element Seqn Id St Int Rpt
TGTIGDEKAEMFRNQVTGK CD36_RAT 418 6 -
TGTIGDEKAEMFKTQVTGK CD36_MOUSE 418 6 -
TGTIGDEKAEMFRNQVTGK CD36_BOVIN 418 6 -
TGTIGDEKANMFRSQVTGK CD36_HUMAN 418 6 -
TGTIGDEKAEMFRNQVTGK CD36_MESAU 418 6 -
TGTIGDEKAEMFRNQVTGK O35754 419 6 -

Motif 13 width=23
Element Seqn Id St Int Rpt
KIKLLGLVEMVLLGVGVVMFVAF CD36_RAT 436 -1 -
KIKLLGMVEMALLGIGVVMFVAF CD36_MOUSE 436 -1 -
KINLLGLVEIVLLSVGVVMFIAF CD36_BOVIN 436 -1 -
KINLLGLIEMILLSVGVVMFVAF CD36_HUMAN 436 -1 -
KVKLLGLVEMVLLGLGVVMFVAF CD36_MESAU 436 -1 -
KIKLLGLVEMVLLGVGVVMFVAF O35754 437 -1 -