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PR01538

Identifier
INTRLEUKN1R1  [View Relations]  [View Alignment]  
Accession
PR01538
No. of Motifs
12
Creation Date
18-JUN-2001
Title
Interleukin-1 receptor type I precursor signature 
Database References
PRINTS; PR01536 INTRLKN1R12F; PR01537 INTRLKN1R1F
PDB; 1ITB; 1IRA
SCOP; 1ITB; 1IRA
CATH; 1ITB; 1IRA
Literature References
1. SIMS, J.E., MARCH, C.J., COSMAN, D., WIDMER, M.B., MACDONALD, H.R., 
MCMAHAN, C.J., GRUBIN, C.E., WIGNALL, J.M., JACKSON, J.L., CALL, S.M. ET AL..
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin
superfamily.
SCIENCE 241 585-589 (1988).
 
2. LIU, C., HART, R.P., LIU, X.J., CLEVENGER, W., MAKI, R.A. 
AND DE SOUZA, E.B.
Cloning and characterization of an alternatively processed human type II
interleukin-1 receptor mRNA.
J.BIOL.CHEM. 271 20965-20972 (1996). 
 
3. MCMAHAN, C.J., SLACK, J.L., MOSLEY, B., COSMAN, D., LUPTON, S.D., 
BRUNTON, L.L., GRUBIN, C.E., WIGNALL, J.M., JENKINS, N.A., BRANNAN, C.I.
ET AL..
A novel IL-1 receptor, cloned from B cells by mammalian expression, is 
expressed in many cell types.
EMBO J. 10 2821-2832 (1991). 
 
4. SCHREUDER, H., TARDIF, C., TRUMP-KALLMEYER, S., SOFFIENTINI, A., 
SARUBBI, E., AKESON, A., BOWLIN, T., YANOFSKY, S. AND BARRETT, R.W.
A new cytokine-receptor binding mode revealed by the crystal structure of
the IL-1 receptor with an antagonist.
NATURE 386 194-200 (1997). 

Documentation
Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are 
cytokines that participate in the regulation of immune responses, 
inflammatory reactions, and hematopoiesis [1]. Two types of IL-1 receptor, 
each with three extracellular immunoglobulin (Ig)-like domains, limited
sequence similarity (28%) and different pharmacological characteristics
have been cloned from mouse and human cell lines: these have been termed 
type I and type II receptors [2]. The receptors both exist in transmembrane
(TM) and soluble forms: the soluble IL-1 receptor is thought to be post-
translationally derived from cleavage of the extracellular portion of the
membrane receptors [2].
 
Both IL-1 receptors appear to be well conserved in evolution, and map to the
same chromosomal location [3]. The receptors can both bind all three forms 
of IL-1 (IL-1 alpha, IL-1 beta and IL-1RA) [3].
 
The crystal structure of the soluble extracellular part of type-I IL1R
complexed with IL1RA has been determined to 2.7A resolution [4]. The
receptor structure is characterised by three Ig-like domains, of which
domains 1 and 2 are tightly linked, while domain 3 is completely separate
and connected by a flexible linker [4].  
 
INTRLEUKN1R1 is a 12-element fingerprint that provides a signature for the
interleukin-1 receptor type I precursor. The fingerprint was derived from
an initial alignment of 3 sequences: the motifs were drawn from short
conserved regions spanning virtually the full alignment length, focusing on
those sections that characterise the interleukin-1 receptor type I precursor
but distinguish it from other members of the interleukin-1 receptor family - 
motifs 1 and 2 lie N-terminal to Ig-like C2-type domain 1; motifs 5 and 6
span Ig-like C2-type domain 2; motifs 8 and 9 reside within Ig-like C2-type
domain 3; motif 10 spans the N-terminal portion of the putative TM domain;
and motifs 11 and 12 reside within the cytoplasmic domain. Two iterations on
SPTR39_15f were required to reach convergence, at which point a true set 
comprising 4 sequences was identified. Several partial matches were also 
found: Q62692 is the soluble IL-1 receptor type I from rat, which matches 
only the N-terminal 7 motifs; Q90874 is the IL-1 receptor i precursor from
chicken, which matches motifs 3, 9 and 10; and Q13525 and Q62929 are 
interleukin-1 receptor-related proteins from human and rat respectively,
which match motifs 3 and 10.
Summary Information
   4 codes involving 12 elements
0 codes involving 11 elements
0 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
1 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
12444444444444
11000000000000
10000000000000
9000000000000
8000000000000
7111111100000
6000000000000
5000000000000
4000000000000
3001000001100
2002000000200
123456789101112
True Positives
IL1R_HUMAN    IL1R_MOUSE    IL1R_RAT      Q9TV71        
True Positive Partials
Codes involving 7 elements
Q62692
Codes involving 3 elements
Q90874
Codes involving 2 elements
Q13525 Q62929
Sequence Titles
IL1R_HUMAN  INTERLEUKIN-1 RECEPTOR, TYPE I PRECURSOR (IL-1R-1) (IL-1R-ALPHA) (P80) (ANTIGEN CD121A) - Homo sapiens (Human). 
IL1R_MOUSE INTERLEUKIN-1 RECEPTOR, TYPE I PRECURSOR (IL-1R-1) (P80) - Mus musculus (Mouse).
IL1R_RAT INTERLEUKIN-1 RECEPTOR, TYPE I PRECURSOR (IL-1R-1) (P80) - Rattus norvegicus (Rat).
Q9TV71 INTERLEUKIN-1 RECEPTOR TYPE I PRECURSOR - Equus caballus (Horse).

Q62692 SOLUBLE IL-1 RECEPTOR TYPE I - Rattus norvegicus (Rat).

Q90874 IL-1 RECEPTOR I PRECURSOR - Gallus gallus (Chicken).

Q13525 INTERLEUKIN-1 RECEPTOR-RELATED PROTEIN - Homo sapiens (Human).
Q62929 INTERLEUKIN-1 RECEPTOR-RELATED PROTEIN - Rattus norvegicus (Rat).
Scan History
SPTR39_15f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
KVLLGLICLMVPLLS IL1R_MOUSE 5 5 -
KVLLGFICLIVPLLS IL1R_RAT 5 5 -
KVLLRLICFIALLIS IL1R_HUMAN 2 2 -

Motif 2 width=25
Element Seqn Id St Int Rpt
LEIDVCTEYPNQIVLFLSVNEIDIR IL1R_MOUSE 20 0 -
LETDKCTEYPNEVISFSSVNEIDIR IL1R_RAT 20 0 -
LEADKCKEREEKIILVSSANEIDVR IL1R_HUMAN 18 1 -

Motif 3 width=14
Element Seqn Id St Int Rpt
KTPISADRDSRIHQ IL1R_MOUSE 66 21 -
KTPISADKDSRIHQ IL1R_RAT 66 21 -
KTPVSTEQASRIHQ IL1R_HUMAN 63 20 -

Motif 4 width=19
Element Seqn Id St Int Rpt
CLKTKVTVTVLENDPGLCY IL1R_MOUSE 107 27 -
CLKTKITMSVLENDPGLCY IL1R_RAT 107 27 -
CLRIKISAKFVENEPNLCY IL1R_HUMAN 104 27 -

Motif 5 width=17
Element Seqn Id St Int Rpt
QATFPQRLHIAGDGSLV IL1R_MOUSE 128 2 -
QASFIQRLHVAGDGSLV IL1R_RAT 128 2 -
QAIFKQKLPVAGDGGLV IL1R_HUMAN 125 2 -

Motif 6 width=18
Element Seqn Id St Int Rpt
CKPLLLDNVSFFGVKDKL IL1R_MOUSE 167 22 -
CKPLPLDDGNFFGFKNKL IL1R_RAT 167 22 -
CKPLLLDNIHFSGVKDRL IL1R_HUMAN 164 22 -

Motif 7 width=15
Element Seqn Id St Int Rpt
VIQFITIDENKRDRP IL1R_MOUSE 215 30 -
VITFITIDDSKRDRP IL1R_RAT 215 30 -
VIEFITLEENKPTRP IL1R_HUMAN 212 30 -

Motif 8 width=18
Element Seqn Id St Int Rpt
DPFLAEDYQFVEHPSTKR IL1R_MOUSE 274 44 -
DPILAEDYQFLEHPSAKR IL1R_RAT 274 44 -
DPVLGEDYYSVENPANKR IL1R_HUMAN 271 44 -

Motif 9 width=20
Element Seqn Id St Int Rpt
TLITTLNISEVKSQFYRYPF IL1R_MOUSE 294 2 -
TLITTLNVSEVKSQFYRYPF IL1R_RAT 294 2 -
TLITVLNISEIESRFYKHPF IL1R_HUMAN 291 2 -

Motif 10 width=18
Element Seqn Id St Int Rpt
YPVPDFKNYLIGGFIILT IL1R_MOUSE 332 18 -
YPVPDFKNYLIGGFAIFT IL1R_RAT 332 18 -
YPVTNFQKHMIGICVTLT IL1R_HUMAN 329 18 -

Motif 11 width=14
Element Seqn Id St Int Rpt
PAQRRSPLSKHRLL IL1R_MOUSE 542 192 -
PAQRRSPLSKHHLL IL1R_RAT 542 192 -
PVQRRSPSSKHQLL IL1R_HUMAN 539 192 -

Motif 12 width=14
Element Seqn Id St Int Rpt
TKEKLPAATHLPLG IL1R_MOUSE 563 7 -
TKEKLQAETHLPLG IL1R_RAT 563 7 -
TKEKLQREAHVPLG IL1R_HUMAN 556 3 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
KVLLGLICLMVPLLS IL1R_MOUSE 5 5 -
KVLLGFICLIVPLLS IL1R_RAT 5 5 -
KVLLRLICFIALLIS IL1R_HUMAN 2 2 -
KVLPRLVCFIALLIS Q9TV71 2 2 -

Motif 2 width=25
Element Seqn Id St Int Rpt
LEIDVCTEYPNQIVLFLSVNEIDIR IL1R_MOUSE 20 0 -
LETDKCTEYPNEVISFSSVNEIDIR IL1R_RAT 20 0 -
LEADKCKEREEKIILVSSANEIDVR IL1R_HUMAN 18 1 -
LEADKCEERGEPIVLVSSAYEIDVR Q9TV71 18 1 -

Motif 3 width=14
Element Seqn Id St Int Rpt
KTPISADRDSRIHQ IL1R_MOUSE 66 21 -
KTPISADKDSRIHQ IL1R_RAT 66 21 -
KTPVSTEQASRIHQ IL1R_HUMAN 63 20 -
ETPVSMERDSRIHQ Q9TV71 63 20 -

Motif 4 width=19
Element Seqn Id St Int Rpt
CLKTKVTVTVLENDPGLCY IL1R_MOUSE 107 27 -
CLKTKITMSVLENDPGLCY IL1R_RAT 107 27 -
CLRIKISAKFVENEPNLCY IL1R_HUMAN 104 27 -
CLKVKITARFVQHEPDLCY Q9TV71 104 27 -

Motif 5 width=17
Element Seqn Id St Int Rpt
QATFPQRLHIAGDGSLV IL1R_MOUSE 128 2 -
QASFIQRLHVAGDGSLV IL1R_RAT 128 2 -
QAIFKQKLPVAGDGGLV IL1R_HUMAN 125 2 -
QAIFTQKLPLGEDGLLV Q9TV71 125 2 -

Motif 6 width=18
Element Seqn Id St Int Rpt
CKPLLLDNVSFFGVKDKL IL1R_MOUSE 167 22 -
CKPLPLDDGNFFGFKNKL IL1R_RAT 167 22 -
CKPLLLDNIHFSGVKDRL IL1R_HUMAN 164 22 -
CQPLLLDNINFIGKTDKL Q9TV71 164 22 -

Motif 7 width=15
Element Seqn Id St Int Rpt
VIQFITIDENKRDRP IL1R_MOUSE 215 30 -
VITFITIDDSKRDRP IL1R_RAT 215 30 -
VIEFITLEENKPTRP IL1R_HUMAN 212 30 -
VIGLITLDEIRPTKP Q9TV71 212 30 -

Motif 8 width=18
Element Seqn Id St Int Rpt
DPFLAEDYQFVEHPSTKR IL1R_MOUSE 274 44 -
DPILAEDYQFLEHPSAKR IL1R_RAT 274 44 -
DPVLGEDYYSVENPANKR IL1R_HUMAN 271 44 -
DPVLVEEYKPVENPSLKR Q9TV71 271 44 -

Motif 9 width=20
Element Seqn Id St Int Rpt
TLITTLNISEVKSQFYRYPF IL1R_MOUSE 294 2 -
TLITTLNVSEVKSQFYRYPF IL1R_RAT 294 2 -
TLITVLNISEIESRFYKHPF IL1R_HUMAN 291 2 -
TLITVLNISAVESRFYLYPF Q9TV71 291 2 -

Motif 10 width=18
Element Seqn Id St Int Rpt
YPVPDFKNYLIGGFIILT IL1R_MOUSE 332 18 -
YPVPDFKNYLIGGFAIFT IL1R_RAT 332 18 -
YPVTNFQKHMIGICVTLT IL1R_HUMAN 329 18 -
QPVPDFQKHVIGIFVLLT Q9TV71 329 18 -

Motif 11 width=14
Element Seqn Id St Int Rpt
PAQRRSPLSKHRLL IL1R_MOUSE 542 192 -
PAQRRSPLSKHHLL IL1R_RAT 542 192 -
PVQRRSPSSKHQLL IL1R_HUMAN 539 192 -
PVQRQLPSSKCQLL Q9TV71 539 192 -

Motif 12 width=14
Element Seqn Id St Int Rpt
TKEKLPAATHLPLG IL1R_MOUSE 563 7 -
TKEKLQAETHLPLG IL1R_RAT 563 7 -
TKEKLQREAHVPLG IL1R_HUMAN 556 3 -
SKEKLQGEVHVPLG Q9TV71 560 7 -