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PR01423

Identifier
TGFBETA  [View Relations]  [View Alignment]  
Accession
PR01423
No. of Motifs
5
Creation Date
01-NOV-2000
Title
Transforming growth factor beta precursor signature
Database References
PRINTS; PR01424 TGFBETA1; PR01425 TGFBETA2; PR01426 TGFBETA3
PRINTS; PR01427 TGFBETA4
PROSITE; PS00250 TGF_BETA
PFAM; PF00019 TGF-beta; PF00688 TGFb_propeptide
INTERPRO; IPR001839
PDB; 1TFG; 2TGI; 1TGJ; 1TGK; 1KLA; 1KLC; 1KLD
SCOP; 1TFG; 2TGI; 1TGJ; 1TGK; 1KLA; 1KLC; 1KLD
CATH; 1TFG; 2TGI; 1TGJ; 1TGK; 1KLA; 1KLC; 1KLD
MIM; 190220; 190230; 190180
Literature References
1. ARCHER, S.J., BAX, A., ROBERTS, A.B., SPORN, M.B., OGAWA, Y., PIEZ, K.A.,
WEATHERBEE, J.A., TSANG, M.L., LUCAS, R. AND ZHENG, B.L.
Transforming growth factor beta 1: NMR signal assignments of the recombinant
protein expressed and isotopically enriched using Chinese hamster ovary cells.
BIOCHEMISTRY 32 1152-1163 (1993). 
 
2. CHEIFETZ, S., WEATHERBEE, J.A., TSANG, M.L.S., ANDERSON, J.K.,
MOLE, J.E., LUCAS, R. AND MASSAGUE, J. 
The transforming growth factor-beta system, a complex pattern of 
cross-reactive ligands and receptors. 
CELL 48 409-415 (1987).
 
3. DERYNCK, R., LINDQUIST, P.B., LEE, A., WEN, D.,
TAMM, J., GRAYCAR, J.L., RHEE, L., MASON, A.J.,
MILLER, D.A., COFFEY, R.J., MOSES, H.L. AND CHEN, E.Y. 
A new type of transforming growth factor-beta, TGF-beta 3. 
EMBO J. 7 3737-3743 (1988).
 
4. JAKOWLEW, S.B., LECHLEIDER, R., GEISER, A.G., KIM, S.J.,
SANTA-COLOMA, T.A., CUBERT, J., SPORN, M.B. AND ROBERTS, A.B. 
Identification and characterization of the chicken transforming growth
factor-beta 3 promoter. 
MOL.ENDOCRINOL. 6 1285-1298 (1992).
 
5. MITTL, P.R., PRIESTLE, J.P., COX, D.A., MCMASTER, G.,
CERLETTI, N. AND GRUTTER, M.G. 
The crystal structure of TGF-beta 3 and comparison to 
TGF-beta 2: implications for receptor binding. 
PROTEIN SCI. 5 1261-1271 (1996).
 
6. HINCK, A.P., ARCHER, S.J., QIAN, S.W., ROBERTS, A.B.,
SPORN, M.B., WEATHERBEE, J.A., TSANG, M.L.-S., LUCAS, R.,
ZHENG, B.-L., WENKER, J. AND TORCHIA, D.A. 
Transforming growth factor beta 1: three-dimensional structure in solution 
and comparison with the X-ray structure of transforming growth 
factor beta 2. 
BIOCHEMISTRY 35 8517-8534 (1996).
 
7. DAOPIN, S., PIEZ, K.A., OGAWA, Y. AND DAVIES, D.R. 
Crystal structure of transforming growth factor-beta 2: an unusual 
fold for the superfamily. 
SCIENCE 257 369-373 (1992).

Documentation
The transforming growth factors-beta (TGF-beta 1-5) constitute a family of
multi-functional cytokines that regulate cell growth and differentiation [1].
Many cells synthesise TGF-beta, and essentially all have specific receptors 
for this peptide [2]. TGF-beta regulates the actions of many other peptide
growth factors and determines a positive or negative direction of their 
effects. The protein functions as a disulphide-linked homodimer. Its
sequence is characterised by the presence of several C-terminal cysteine
residues, which form interlocking disulphide links arranged in a knot-like
topology. A similar "cystine-knot" arrangement has been noted in the
structures of some enzyme inhibitors and neurotoxins that bind to voltage-
gated Ca2+ channels, although the precise topology differs. 
 
The three-dimensional structures of several members of the TGF-beta super-
family have been deduced [5-7]. The solution structure of human TGF-beta 1
was determined using multinuclear magnetic resonance spectroscopy with
hybrid distance geometry/simulated annealing [6]. The structure shows a high
degree of similarity to that of TGF-beta 2, but with notable differences in
structure and flexibility [6]. The crystal structure of the TGF-beta 2
monomer lacks a well-defined hydrophobic core and displays an unusual
elongated non-globular fold [7]. Eight cysteine residues form 4 intra-chain
disulphide bonds, creating the characteristic knotted arrangement. The dimer
is stabilised by a ninth cysteine, which forms an inter-chain disulphide 
bond, and by 2 identical hydrophobic interfaces. Other members of the TGF-
beta superfamily, including activins, inhibins and various developmental
factors, are also likely to adopt the TGF-beta fold. The crystal structure
of TGF-beta 3 reveals a near identical central core to that of TGF-beta 2 
[5]. The principal differences are witnessed in the conformations of the 
N-terminal alpha-helix and in the beta-sheet loops [5], which could account
for the individual cellular responses, if these differences are recognised
by the TGF-beta receptors.
 
TGFBETA is a 5-element fingerprint that provides a signature for the
transforming growth factor beta precursor superfamily. The fingerprint was
derived from an initial alignment of 18 sequences: the motifs were drawn
from conserved regions spanning the N-terminal half of the alignment. Two 
iterations on SPTR39_14f were required to reach convergence, at which point
a true set comprising 26 sequences was identified. Several partial matches
were also found, all of which are family members that fail to make
significant matches with one or more motifs.
Summary Information
  26 codes involving  5 elements
0 codes involving 4 elements
5 codes involving 3 elements
4 codes involving 2 elements
Composite Feature Index
52626262626
400000
341145
202024
12345
True Positives
Q15579        Q9R281        Q9R298        Q9R2B8        
Q9TUM8 Q9WUQ8 Q9Z1Y6 TGB1_SHEEP
TGF1_CANFA TGF1_CERAE TGF1_HORSE TGF1_HUMAN
TGF1_MOUSE TGF1_PIG TGF1_RAT TGF1_XENLA
TGF2_CHICK TGF2_HUMAN TGF2_MOUSE TGF2_PIG
TGF2_XENLA TGF3_CHICK TGF3_HUMAN TGF3_MOUSE
TGF3_PIG TGF3_RAT
True Positive Partials
Codes involving 3 elements
O75610 O75611 Q9PTQ2 TGF4_HUMAN
TGF4_MOUSE
Codes involving 2 elements
O93449 Q9PVN4 Q9PWA9 Q9W6I7
Sequence Titles
Q15579      TRANSFORMING GROWTH FACTOR-BETA-2 PRECURSOR - Homo sapiens (Human). 
Q9R281 TRANSFORMING GROWTH FACTOR BETA 2 PRECURSOR - Rattus norvegicus (Rat).
Q9R298 TGF-BETA 2 SHORT FORM PRECURSOR - Rattus norvegicus (Rat).
Q9R2B8 TGF-BETA2 PROTEIN - Rattus norvegicus (Rat).
Q9TUM8 TRANSFORMING GROWTH FACTOR BETA 1 - Equus caballus (Horse).
Q9WUQ8 TGF-BETA 2 LONG FORM PRECURSOR - Rattus norvegicus (Rat).
Q9Z1Y6 TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) (INTERLEUKIN TGF BETA) - Cavia porcellus (Guinea pig).
TGB1_SHEEP TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) - OVIS ARIES (SHEEP).
TGF1_CANFA TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) - Canis familiaris (Dog).
TGF1_CERAE TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) - Cercopithecus aethiops (Green monkey) (Grivet).
TGF1_HORSE TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) - Equus caballus (Horse).
TGF1_HUMAN TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) - Homo sapiens (Human).
TGF1_MOUSE TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) - Mus musculus (Mouse).
TGF1_PIG TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) - Sus scrofa (Pig).
TGF1_RAT TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) - Rattus norvegicus (Rat).
TGF1_XENLA TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1) (TGF-BETA 5) - Xenopus laevis (African clawed frog).
TGF2_CHICK TRANSFORMING GROWTH FACTOR BETA 2 PRECURSOR (TGF-BETA 2) - Gallus gallus (Chicken).
TGF2_HUMAN TRANSFORMING GROWTH FACTOR BETA 2 PRECURSOR (TGF-BETA 2) (GLIOBLASTOMA -DERIVED T-CELL SUPPRESSOR FACTOR) (G-TSF) (BSC-1 CELL GROWTH INHIBITOR) (POLYERGIN) (CETERMIN) - Homo sapiens (Human), and Cercopithecus aethiops (Green monkey) (Grivet).
TGF2_MOUSE TRANSFORMING GROWTH FACTOR BETA 2 PRECURSOR (TGF-BETA 2) - Mus musculus (Mouse).
TGF2_PIG TRANSFORMING GROWTH FACTOR BETA 2 PRECURSOR (TGF-BETA 2) - Sus scrofa (Pig).
TGF2_XENLA TRANSFORMING GROWTH FACTOR BETA 2 PRECURSOR (TGF-BETA 2) - Xenopus laevis (African clawed frog).
TGF3_CHICK TRANSFORMING GROWTH FACTOR BETA 3 PRECURSOR (TGF-BETA 3) - Gallus gallus (Chicken).
TGF3_HUMAN TRANSFORMING GROWTH FACTOR BETA 3 PRECURSOR (TGF-BETA 3) - Homo sapiens (Human).
TGF3_MOUSE TRANSFORMING GROWTH FACTOR BETA 3 PRECURSOR (TGF-BETA 3) - Mus musculus (Mouse).
TGF3_PIG TRANSFORMING GROWTH FACTOR BETA 3 PRECURSOR (TGF-BETA 3) - Sus scrofa (Pig).
TGF3_RAT TRANSFORMING GROWTH FACTOR BETA 3 PRECURSOR (TGF-BETA 3) - Rattus norvegicus (Rat).

O75610 SIGNALING MOLECULE LEFTY-B - Homo sapiens (Human).
O75611 SIGNALING MOLECULE LEFTY-A - Homo sapiens (Human).
Q9PTQ2 TRANSFORMING GROWTH FACTOR BETA PRECURSOR - Cyprinus carpio (Common carp).
TGF4_HUMAN TRANSFORMING GROWTH FACTOR BETA 4 PRECURSOR (TGF-BETA 4) (ENDOMETRIAL BLEEDING-ASSOCIATED FACTOR) - Homo sapiens (Human).
TGF4_MOUSE TRANSFORMING GROWTH FACTOR BETA 4 PRECURSOR (TGF-BETA 4) (LEFTY PROTEIN) (STRA3 PROTEIN) - Mus musculus (Mouse).

O93449 TRANSFORMING GROWTH FACTOR BETA PRECURSOR - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q9PVN4 LEFTY - Gallus gallus (Chicken).
Q9PWA9 TRANSFORMING GROWTH FACTOR BETA PRECURSOR - Morone chrysops x Morone saxatilis (white bass x striped bass).
Q9W6I7 SIGNALING MOLECULE LEFTY2 - Brachydanio rerio (Zebrafish) (Zebra danio).
Scan History
SPTR39_14f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
WLLVLTPGRPAAGLSTCKTI TGF1_PIG 17 17 -
WLLVLTPGRPAAGLSTCKTI TGF1_HUMAN 17 17 -
WLLVLTPGRPAAGLSTCKTI TGF1_HORSE 17 17 -
RLLVLTPGRPAAGLSTCKTI TGF1_CANFA 17 17 -
WLLVLTPGRPAAGLSTCKTI TGF1_MOUSE 17 17 -
WLLVLTPSRPAAGLSTCKTI TGF1_CERAE 17 17 -
VLALLNLATVSLSLSTCTTL TGF3_RAT 11 11 -
WLLVLTPGRPAAGLSTCKTI TGF1_RAT 17 17 -
VLALLNLATISLSLSTCTTL TGF3_MOUSE 9 9 -
VLALLNFATVSLSLSTCTTL TGF3_HUMAN 11 11 -
AFLLLHLVTVALSLSTCSTL TGF2_PIG 8 8 -
AFLILHLVTVALSLSTCSTL TGF2_HUMAN 8 8 -
TFLLLHLVPVALSLSTCSTL TGF2_MOUSE 8 8 -
VFLTLDLAAVALSLSTCSTL TGF2_CHICK 8 8 -
LLSLLSFATVSLALSSCTTL TGF3_CHICK 11 11 -
VLALLNFATVSLSMSTCTTL TGF3_PIG 9 9 -
TFLTLDLAPVALSLSTCSAL TGF2_XENLA 8 8 -
VLLVLHLSSLAMSLSTCKAV TGF1_XENLA 9 9 -

Motif 2 width=13
Element Seqn Id St Int Rpt
PLPEAVLALYNST TGF1_PIG 72 35 -
PLPEAVLALYNST TGF1_HUMAN 72 35 -
PLPEAVLALYNST TGF1_HORSE 72 35 -
PLPEAVLALYNST TGF1_CANFA 72 35 -
PLPEAVLALYNST TGF1_MOUSE 72 35 -
PLPEAVLALYNST TGF1_CERAE 72 35 -
HVPYQVLALYNST TGF3_RAT 64 33 -
PLPEAVLALYNST TGF1_RAT 72 35 -
HVPYQVLALYNST TGF3_MOUSE 62 33 -
HVPYQVLALYNST TGF3_HUMAN 64 33 -
EVPPEVISIYNST TGF2_PIG 62 34 -
EVPPEVISIYNST TGF2_HUMAN 62 34 -
EVPPEVISIYNST TGF2_MOUSE 62 34 -
EVPPEVISIYNST TGF2_CHICK 62 34 -
HVPYQILALYNST TGF3_CHICK 64 33 -
NIPTQVLDLYNST TGF3_PIG 62 33 -
EVSQDVISIYNST TGF2_XENLA 62 34 -
TVPSEAIFLYNST TGF1_XENLA 63 34 -

Motif 3 width=15
Element Seqn Id St Int Rpt
KVEQHVELYQKYSND TGF1_PIG 163 78 -
KVEQHVELYQKYSNN TGF1_HUMAN 163 78 -
SVEQHVELYQKYSNN TGF1_HORSE 163 78 -
KAEQHVELYQKYSND TGF1_CANFA 163 78 -
SVEQHVELYQKYSNN TGF1_MOUSE 163 78 -
KVEQHVELYQKYSNN TGF1_CERAE 163 78 -
RTEQRIELFQILRPD TGF3_RAT 163 86 -
TVEQHVELYQKYSNN TGF1_RAT 163 78 -
RTEQRIELFQILRPD TGF3_MOUSE 161 86 -
RNEQRIELFQILRPD TGF3_HUMAN 163 86 -
VAEQRIELYQILKSK TGF2_PIG 161 86 -
VPEQRIELYQILKSK TGF2_HUMAN 161 86 -
VAEQRIELYQILKSK TGF2_MOUSE 161 86 -
VSEQRIELYQVLKSK TGF2_CHICK 160 85 -
RSEQRIELFQILRPD TGF3_CHICK 163 86 -
RSEQRIELFQILQPD TGF3_PIG 161 86 -
VSEQRIELYQILKSK TGF2_XENLA 161 86 -
NMDQRMELFWKYQEN TGF1_XENLA 152 76 -

Motif 4 width=16
Element Seqn Id St Int Rpt
SWRYLSNRLLAPSDSP TGF1_PIG 178 0 -
SWRYLSNRLLAPSDSP TGF1_HUMAN 178 0 -
SWRYLSNRLLTPSDSP TGF1_HORSE 178 0 -
SWRYLSNRLLAPSDTP TGF1_CANFA 178 0 -
SWRYLGNRLLTPTDTP TGF1_MOUSE 178 0 -
SWRYLSNRLLAPSNSP TGF1_CERAE 178 0 -
KQRYIGGKNLPTRGTA TGF3_RAT 182 4 -
SWRYLGNRLLTPTDTP TGF1_RAT 178 0 -
KQRYIGGKNLPTRGTA TGF3_MOUSE 180 4 -
KQRYIGGKNLPTRGTA TGF3_HUMAN 182 4 -
TQRYIDSKVVKTRAEG TGF2_PIG 181 5 -
TQRYIDSKVVKTRAEG TGF2_HUMAN 181 5 -
TQRYIDSKVVKTRAEG TGF2_MOUSE 181 5 -
GQRYIDSKVVKTRAEG TGF2_CHICK 180 5 -
KQRYLSGRNVQTRGSP TGF3_CHICK 182 4 -
KQRYIDGKNLPTRGAA TGF3_PIG 180 4 -
TQRYIDSKVVKTRAEG TGF2_XENLA 181 5 -
HSRYLESKYITPVTDD TGF1_XENLA 170 3 -

Motif 5 width=15
Element Seqn Id St Int Rpt
WLSFDVTGVVRQWLT TGF1_PIG 195 1 -
WLSFDVTGVVRQWLS TGF1_HUMAN 195 1 -
WLSFDVTGVVRQWLS TGF1_HORSE 195 1 -
WLSFDVTGVVRQWLS TGF1_CANFA 195 1 -
WLSFDVTGVVRQWLN TGF1_MOUSE 195 1 -
WLSFDVTGVVRQWLS TGF1_CERAE 195 1 -
WLSFDVTDTVREWLL TGF3_RAT 199 1 -
WLSFDVTGVVRQWLN TGF1_RAT 195 1 -
WLSFDVTDTVREWLL TGF3_MOUSE 197 1 -
WLSFDVTDTVREWLL TGF3_HUMAN 199 1 -
WLSFDVTDAVHEWLH TGF2_PIG 198 1 -
WLSFDVTDAVHEWLH TGF2_HUMAN 198 1 -
WLSFDVTDAVQEWLH TGF2_MOUSE 198 1 -
WLSFDVTEAVHEWLH TGF2_CHICK 197 1 -
WLSFDVTDTVREWLL TGF3_CHICK 199 1 -
WLSFDVTDTVREWLL TGF3_PIG 197 1 -
WLSFDVTEAVNEWLH TGF2_XENLA 198 1 -
WMSFDVTKTVNEWLK TGF1_XENLA 187 1 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
WLLVLTPGRPAAGLSTCKTI TGF1_PIG 17 17 -
WLLVLTPGRPAAGLSTCKTI TGF1_HUMAN 17 17 -
WLLVLTPGRPAAGLSTCKTI Q9TUM8 17 17 -
WLLVLTPGRPAAGLSTCKTI TGF1_HORSE 17 17 -
RLLVLTPGRPAAGLSTCKTI TGF1_CANFA 17 17 -
WLLVLTPGRPAAGLSTCKTI TGF1_MOUSE 17 17 -
WLLVLTPSRPAAGLSTCKTI TGF1_CERAE 17 17 -
VLALLNLATVSLSLSTCTTL TGF3_RAT 11 11 -
WLLVLTPGRPAAGLSTCKTI TGF1_RAT 17 17 -
VLALLNLATISLSLSTCTTL TGF3_MOUSE 9 9 -
VLALLNFATVSLSLSTCTTL TGF3_HUMAN 11 11 -
AFLLLHLVTVALSLSTCSTL TGF2_PIG 8 8 -
TFLLLHLVPVALSLSTCSTL Q9R281 8 8 -
TFLLLHLVPVALSLSTCSTL Q9R298 8 8 -
TFLLLHLVPVALSLSTCSTL Q9R2B8 8 8 -
TFLLLHLVPVALSLSTCSTL Q9WUQ8 8 8 -
AFLILHLVTVALSLSTCSTL Q15579 8 8 -
AFLILHLVTVALSLSTCSTL TGF2_HUMAN 8 8 -
TFLLLHLVPVALSLSTCSTL TGF2_MOUSE 8 8 -
VFLTLDLAAVALSLSTCSTL TGF2_CHICK 8 8 -
WLLMLTPGRPVAGLSTCKTI TGB1_SHEEP 17 17 -
WLLVLAPGRPASGLSTCKTI Q9Z1Y6 17 17 -
LLSLLSFATVSLALSSCTTL TGF3_CHICK 11 11 -
VLALLNFATVSLSMSTCTTL TGF3_PIG 9 9 -
TFLTLDLAPVALSLSTCSAL TGF2_XENLA 8 8 -
VLLVLHLSSLAMSLSTCKAV TGF1_XENLA 9 9 -

Motif 2 width=13
Element Seqn Id St Int Rpt
PLPEAVLALYNST TGF1_PIG 72 35 -
PLPEAVLALYNST TGF1_HUMAN 72 35 -
PLPEAVLALYNST Q9TUM8 72 35 -
PLPEAVLALYNST TGF1_HORSE 72 35 -
PLPEAVLALYNST TGF1_CANFA 72 35 -
PLPEAVLALYNST TGF1_MOUSE 72 35 -
PLPEAVLALYNST TGF1_CERAE 72 35 -
HVPYQVLALYNST TGF3_RAT 64 33 -
PLPEAVLALYNST TGF1_RAT 72 35 -
HVPYQVLALYNST TGF3_MOUSE 62 33 -
HVPYQVLALYNST TGF3_HUMAN 64 33 -
EVPPEVISIYNST TGF2_PIG 62 34 -
EVPPEVISIYNST Q9R281 62 34 -
EVPPEVISIYNST Q9R298 62 34 -
EVPPEVISIYNST Q9R2B8 62 34 -
EVPPEVISIYNST Q9WUQ8 62 34 -
EVPPEVISIYNST Q15579 62 34 -
EVPPEVISIYNST TGF2_HUMAN 62 34 -
EVPPEVISIYNST TGF2_MOUSE 62 34 -
EVPPEVISIYNST TGF2_CHICK 62 34 -
PLPEAILALYNST TGB1_SHEEP 72 35 -
PLPEAVLALYNST Q9Z1Y6 72 35 -
HVPYQILALYNST TGF3_CHICK 64 33 -
NIPTQVLDLYNST TGF3_PIG 62 33 -
EVSQDVISIYNST TGF2_XENLA 62 34 -
TVPSEAIFLYNST TGF1_XENLA 63 34 -

Motif 3 width=15
Element Seqn Id St Int Rpt
KVEQHVELYQKYSND TGF1_PIG 163 78 -
KVEQHVELYQKYSNN TGF1_HUMAN 163 78 -
SVEQHVELYQKYSNN Q9TUM8 163 78 -
SVEQHVELYQKYSNN TGF1_HORSE 163 78 -
KAEQHVELYQKYSND TGF1_CANFA 163 78 -
SVEQHVELYQKYSNN TGF1_MOUSE 163 78 -
KVEQHVELYQKYSNN TGF1_CERAE 163 78 -
RTEQRIELFQILRPD TGF3_RAT 163 86 -
TVEQHVELYQKYSNN TGF1_RAT 163 78 -
RTEQRIELFQILRPD TGF3_MOUSE 161 86 -
RNEQRIELFQILRPD TGF3_HUMAN 163 86 -
VAEQRIELYQILKSK TGF2_PIG 161 86 -
VAEQRIELYQILKSK Q9R281 161 86 -
VAEQRIELYQILKSK Q9R298 161 86 -
VAEQRIELYQILKSK Q9R2B8 161 86 -
VAEQRIELYQILKSK Q9WUQ8 189 114 -
VPEQRIELYQILKSK Q15579 189 114 -
VPEQRIELYQILKSK TGF2_HUMAN 161 86 -
VAEQRIELYQILKSK TGF2_MOUSE 161 86 -
VSEQRIELYQVLKSK TGF2_CHICK 160 85 -
KVEQHVELYQKYSNN TGB1_SHEEP 163 78 -
NVEQHVELYQKYSNN Q9Z1Y6 163 78 -
RSEQRIELFQILRPD TGF3_CHICK 163 86 -
RSEQRIELFQILQPD TGF3_PIG 161 86 -
VSEQRIELYQILKSK TGF2_XENLA 161 86 -
NMDQRMELFWKYQEN TGF1_XENLA 152 76 -

Motif 4 width=16
Element Seqn Id St Int Rpt
SWRYLSNRLLAPSDSP TGF1_PIG 178 0 -
SWRYLSNRLLAPSDSP TGF1_HUMAN 178 0 -
SWRYLSNRLLTPSDSP Q9TUM8 178 0 -
SWRYLSNRLLTPSDSP TGF1_HORSE 178 0 -
SWRYLSNRLLAPSDTP TGF1_CANFA 178 0 -
SWRYLGNRLLTPTDTP TGF1_MOUSE 178 0 -
SWRYLSNRLLAPSNSP TGF1_CERAE 178 0 -
KQRYIGGKNLPTRGTA TGF3_RAT 182 4 -
SWRYLGNRLLTPTDTP TGF1_RAT 178 0 -
KQRYIGGKNLPTRGTA TGF3_MOUSE 180 4 -
KQRYIGGKNLPTRGTA TGF3_HUMAN 182 4 -
TQRYIDSKVVKTRAEG TGF2_PIG 181 5 -
TQRYIDSKVVKTRAEG Q9R281 181 5 -
TQRYIDSKVVKTRAEG Q9R298 181 5 -
TQRYIDSKVVKTRAEG Q9R2B8 181 5 -
TQRYIDSKVVKTRAEG Q9WUQ8 209 5 -
TQRYIDSKVVKTRAEG Q15579 209 5 -
TQRYIDSKVVKTRAEG TGF2_HUMAN 181 5 -
TQRYIDSKVVKTRAEG TGF2_MOUSE 181 5 -
GQRYIDSKVVKTRAEG TGF2_CHICK 180 5 -
SWRYLSNRLLAPSDSP TGB1_SHEEP 178 0 -
SWRYLSNQLLTPSDTP Q9Z1Y6 178 0 -
KQRYLSGRNVQTRGSP TGF3_CHICK 182 4 -
KQRYIDGKNLPTRGAA TGF3_PIG 180 4 -
TQRYIDSKVVKTRAEG TGF2_XENLA 181 5 -
HSRYLESKYITPVTDD TGF1_XENLA 170 3 -

Motif 5 width=15
Element Seqn Id St Int Rpt
WLSFDVTGVVRQWLT TGF1_PIG 195 1 -
WLSFDVTGVVRQWLS TGF1_HUMAN 195 1 -
WLSFDVTGVVRQWLS Q9TUM8 195 1 -
WLSFDVTGVVRQWLS TGF1_HORSE 195 1 -
WLSFDVTGVVRQWLS TGF1_CANFA 195 1 -
WLSFDVTGVVRQWLN TGF1_MOUSE 195 1 -
WLSFDVTGVVRQWLS TGF1_CERAE 195 1 -
WLSFDVTDTVREWLL TGF3_RAT 199 1 -
WLSFDVTGVVRQWLN TGF1_RAT 195 1 -
WLSFDVTDTVREWLL TGF3_MOUSE 197 1 -
WLSFDVTDTVREWLL TGF3_HUMAN 199 1 -
WLSFDVTDAVHEWLH TGF2_PIG 198 1 -
WLSFDVTDAVHEWLH Q9R281 198 1 -
WLSFDVTDAVHEWLH Q9R298 198 1 -
WLSFDVTDAVHEWLH Q9R2B8 198 1 -
WLSFDVTDAVHEWLH Q9WUQ8 226 1 -
WLSFDVTDAVHEWLH Q15579 226 1 -
WLSFDVTDAVHEWLH TGF2_HUMAN 198 1 -
WLSFDVTDAVQEWLH TGF2_MOUSE 198 1 -
WLSFDVTEAVHEWLH TGF2_CHICK 197 1 -
WLSFDVTGVVRQWLT TGB1_SHEEP 195 1 -
WLSFDVTGVVRQWLS Q9Z1Y6 195 1 -
WLSFDVTDTVREWLL TGF3_CHICK 199 1 -
WLSFDVTDTVREWLL TGF3_PIG 197 1 -
WLSFDVTEAVNEWLH TGF2_XENLA 198 1 -
WMSFDVTKTVNEWLK TGF1_XENLA 187 1 -