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PR01261

Identifier
TAUPROTEIN  [View Relations]  [View Alignment]  
Accession
PR01261
No. of Motifs
6
Creation Date
05-NOV-1999
Title
Tau protein signature
Database References

PRODOM; PD004314; PD150861
INTERPRO; IPR002955
Literature References
1. SPILLANTINI, M.G. AND GOEDERT, M.
Tau protein pathology in neurodegenerative diseases.
TRENDS NEUROSCIENCE 21 428-433 (1998).
 
2. HARADA, A., OGUCHI, K., OKABE, S., KUNO, J., TERADA, S., OHSHIMA, T.,
SATO-YOSHITAKE, R., TAKEI, Y., NODA, T. AND HIROKAWA, N.
Altered microtubule organization in small-calibre axons of mice lacking
tau protein.
NATURE 369 488-491 (1994).
 
3. WILHELMSEN, K.C.
The tangled biology of tau.
PROC.NATL.ACAD.SCI.U.S.A. 96 7120-7121 (1999).

Documentation
Tau proteins are microtubule-associated proteins that are involved in
microtubule assembly and stabilisation. Tau mRNA is expressed predominantly
in neurones, and particularly in their axons. Quite a number of isoforms
have been detected, which in human brain have been shown to arise from
alternative splicing of an mRNA from a single gene located on chromosome 17.
The isoforms contain 352-441 amino acid residues. A larger tau isoform has
also been detected, which is expressed principally in the peripheral nervous
system [1]. Each isoform contains a variable number of C-terminal repeat
regions that are thought to be responsible for tubulin-binding, and a 
variable N-terminal region, whose function remains uncertain.
 
Tau does not appear to be an essential protein, since transgenic mice
lacking tau appear to develop a normal nervous system with only mild
alterations in the structure of certain small-calibre axons [2]. However,
it has received much recent attention due to its possible role in the
aetiogenesis of a number of human neurodegenerative diseases, filamentous
inclusions containing tau having been found in the brains of patients
diagnosed with Alzheimer's disease, Pick's disease and progressive
supranuclear palsy. Furthermore, tau gene mutations have been found in
patients suffering familial frontotemporal dementia, which result in
abnormal tau protein aggregates forming in the brain tissue [3].
 
TAUPROTEIN is a 6-element fingerprint that provides a signature for tau
proteins. The fingerprint was derived from an initial alignment of 11 
sequences: the motifs were drawn from conserved regions within the
N-terminal half of the alignment - motifs 1-5 lie within the N-terminal
region proximal to the tubulin-binding repeats; and motif 6 spans the end
of the N-terminal region and the start of the first tubulin-binding repeat.
Two iterations on SPTR37_10f were required to reach convergence, at which
point a true set comprising 18 sequences was identified.
Summary Information
18 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6181818181818
5000000
4000000
3000000
2000000
123456
True Positives
O02828        Q28185        Q28186        Q28187        
Q28188 Q28189 Q28190 Q60684
Q60685 Q60686 Q63567 Q63677
TAU1_BOVIN TAU2_MOUSE TAU3_BOVIN TAU3_MOUSE
TAU_HUMAN TAU_RAT
Sequence Titles
O02828      MICROTUBULE-ASSOCIATED PROTEIN TAU - CAPRA HIRCUS (GOAT). 
Q28185 TAU PROTEIN - BOS TAURUS (BOVINE).
Q28186 TAU PROTEIN - BOS TAURUS (BOVINE).
Q28187 TAU PROTEIN - BOS TAURUS (BOVINE).
Q28188 TAU PROTEIN - BOS TAURUS (BOVINE).
Q28189 TAU PROTEIN - BOS TAURUS (BOVINE).
Q28190 TAU PROTEIN - BOS TAURUS (BOVINE).
Q60684 MICROTUBULE-ASSOCIATED PROTEIN TAU ISOFORM 23 - MUS MUSCULUS (MOUSE).
Q60685 MICROTUBULE-ASSOCIATED PROTEIN TAU ISOFORM 4 - MUS MUSCULUS (MOUSE).
Q60686 MICROTUBULE-ASSOCIATED PROTEIN TAU ISOFORM 5 - MUS MUSCULUS (MOUSE).
Q63567 BIG TAU - RATTUS NORVEGICUS (RAT).
Q63677 MICROTUBULE ASSOCIATED PROTEIN - RATTUS NORVEGICUS (RAT).
TAU1_BOVIN MICROTUBULE-ASSOCIATED PROTEIN TAU FORMS 1 AND 2 - BOS TAURUS (BOVINE).
TAU2_MOUSE MICROTUBULE-ASSOCIATED PROTEIN TAU (CLONE TA2) - MUS MUSCULUS (MOUSE).
TAU3_BOVIN MICROTUBULE-ASSOCIATED PROTEIN TAU FORMS 3, 4, AND 5 - BOS TAURUS (BOVINE).
TAU3_MOUSE MICROTUBULE-ASSOCIATED PROTEIN TAU (CLONE TA3) - MUS MUSCULUS (MOUSE).
TAU_HUMAN MICROTUBULE-ASSOCIATED PROTEIN TAU - HOMO SAPIENS (HUMAN).
TAU_RAT MICROTUBULE-ASSOCIATED PROTEIN TAU - RATTUS NORVEGICUS (RAT).
Scan History
SPTR37_10f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
KIATPRGAAPPG O02828 111 111 -
KIATPRGAAPPG TAU_HUMAN 150 150 -
KIATPRGAAPPG TAU3_BOVIN 113 113 -
KIATPRGAAPPG TAU1_BOVIN 141 141 -
KIATPRGAAPPG Q28186 90 90 -
KIATPRGAAPPG Q28185 112 112 -
KIATPRGAATPG TAU_RAT 141 141 -
KIATPRGAASPA Q60684 139 139 -
KIATPRGAASPA Q60686 59 59 -
KIATPRGAASPA TAU2_MOUSE 81 81 -
KIATPRGAASPA TAU3_MOUSE 81 81 -

Motif 2 width=10
Element Seqn Id St Int Rpt
QKGQANATRI O02828 123 0 -
QKGQANATRI TAU_HUMAN 162 0 -
QKGQANATRI TAU3_BOVIN 125 0 -
QKGQANATRI TAU1_BOVIN 153 0 -
QKGQANATRI Q28186 102 0 -
QKGQANATRI Q28185 124 0 -
QKGTSNATRI TAU_RAT 153 0 -
QKGTSNATRI Q60684 151 0 -
QKGTSNATRI Q60686 71 0 -
QKGTSNATRI TAU2_MOUSE 93 0 -
QKGTSNATRI TAU3_MOUSE 93 0 -

Motif 3 width=8
Element Seqn Id St Int Rpt
GESGKSGD O02828 147 14 -
GEPPKSGD TAU_HUMAN 186 14 -
GESGKSGD TAU3_BOVIN 147 12 -
GESGKSGD TAU1_BOVIN 193 30 -
GESGKSGD Q28186 142 30 -
GESGKSGD Q28185 146 12 -
GEPPKSGE TAU_RAT 177 14 -
GEPPKSGE Q60684 175 14 -
GEPPKSGE Q60686 95 14 -
GEPPKSGE TAU2_MOUSE 117 14 -
GEPPKSGE TAU3_MOUSE 117 14 -

Motif 4 width=9
Element Seqn Id St Int Rpt
PSLPTPPTR O02828 174 19 -
PSLPTPPTR TAU_HUMAN 213 19 -
PSLPTPPTR TAU3_BOVIN 174 19 -
PSLPTPPTR TAU1_BOVIN 220 19 -
PSLPTPPTR Q28186 169 19 -
PSLPTPPTR Q28185 173 19 -
PSLPTPPTR TAU_RAT 204 19 -
PSLPTPPTR Q60684 202 19 -
PSLPTPPTR Q60686 122 19 -
PSLPTPPTR TAU2_MOUSE 144 19 -
PSLPTPPTR TAU3_MOUSE 144 19 -

Motif 5 width=8
Element Seqn Id St Int Rpt
EPKKVAVV O02828 183 0 -
EPKKVAVV TAU_HUMAN 222 0 -
EPKKVAVV TAU3_BOVIN 183 0 -
EPKKVAVV TAU1_BOVIN 229 0 -
EPKKVAVV Q28186 178 0 -
EPKKVAVV Q28185 182 0 -
EPKKVAVV TAU_RAT 213 0 -
EPKKVAVV Q60684 211 0 -
EPKKVAVV Q60686 131 0 -
EPKKVAVV TAU2_MOUSE 153 0 -
EPKKVAVV TAU3_MOUSE 153 0 -

Motif 6 width=10
Element Seqn Id St Int Rpt
QAAPGPMPDL O02828 205 14 -
QTAPVPMPDL TAU_HUMAN 244 14 -
QAAPGPMPDL TAU3_BOVIN 205 14 -
QAAPGPMPDL TAU1_BOVIN 251 14 -
QAAPGPMPDL Q28186 200 14 -
QAAPGPMPDL Q28185 204 14 -
QTAPVPMPDL TAU_RAT 235 14 -
QTAPVPMPDL Q60684 233 14 -
QTAPVPMPDL Q60686 153 14 -
QTAPVPMPDL TAU2_MOUSE 175 14 -
QTAPVPMPDL TAU3_MOUSE 175 14 -
Final Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
KIATPRGAAPPG O02828 111 111 -
KIATPRGAAPPG TAU_HUMAN 150 150 -
KIATPRGAAPPG TAU3_BOVIN 113 113 -
KIATPRGAAPPG TAU1_BOVIN 141 141 -
KIATPRGAAPPG Q28190 112 112 -
KIATPRGAAPPG Q28189 90 90 -
KIATPRGAAPPG Q28188 90 90 -
KIATPRGAAPPG Q28187 141 141 -
KIATPRGAAPPG Q28186 90 90 -
KIATPRGAAPPG Q28185 112 112 -
KIATPRGAATPG Q63567 395 395 -
KIATPRGAATPG Q63677 83 83 -
KIATPRGAATPG TAU_RAT 141 141 -
KIATPRGAASPA Q60684 139 139 -
KIATPRGAASPA Q60685 81 81 -
KIATPRGAASPA Q60686 59 59 -
KIATPRGAASPA TAU2_MOUSE 81 81 -
KIATPRGAASPA TAU3_MOUSE 81 81 -

Motif 2 width=10
Element Seqn Id St Int Rpt
QKGQANATRI O02828 123 0 -
QKGQANATRI TAU_HUMAN 162 0 -
QKGQANATRI TAU3_BOVIN 125 0 -
QKGQANATRI TAU1_BOVIN 153 0 -
QKGQANATRI Q28190 124 0 -
QKGQANATRI Q28189 102 0 -
QKGQANATRI Q28188 102 0 -
QKGQANATRI Q28187 153 0 -
QKGQANATRI Q28186 102 0 -
QKGQANATRI Q28185 124 0 -
QKGTSNATRI Q63567 407 0 -
QKGTSNATRI Q63677 95 0 -
QKGTSNATRI TAU_RAT 153 0 -
QKGTSNATRI Q60684 151 0 -
QKGTSNATRI Q60685 93 0 -
QKGTSNATRI Q60686 71 0 -
QKGTSNATRI TAU2_MOUSE 93 0 -
QKGTSNATRI TAU3_MOUSE 93 0 -

Motif 3 width=8
Element Seqn Id St Int Rpt
GESGKSGD O02828 147 14 -
GEPPKSGD TAU_HUMAN 186 14 -
GESGKSGD TAU3_BOVIN 147 12 -
GESGKSGD TAU1_BOVIN 193 30 -
GESGKSGD Q28190 146 12 -
GESGKSGD Q28189 124 12 -
GESGKSGD Q28188 124 12 -
GESGKSGD Q28187 193 30 -
GESGKSGD Q28186 142 30 -
GESGKSGD Q28185 146 12 -
GEPPKSGE Q63567 431 14 -
GEPPKSGE Q63677 119 14 -
GEPPKSGE TAU_RAT 177 14 -
GEPPKSGE Q60684 175 14 -
GEPPKSGE Q60685 117 14 -
GEPPKSGE Q60686 95 14 -
GEPPKSGE TAU2_MOUSE 117 14 -
GEPPKSGE TAU3_MOUSE 117 14 -

Motif 4 width=9
Element Seqn Id St Int Rpt
PSLPTPPTR O02828 174 19 -
PSLPTPPTR TAU_HUMAN 213 19 -
PSLPTPPTR TAU3_BOVIN 174 19 -
PSLPTPPTR TAU1_BOVIN 220 19 -
PSLPTPPTR Q28190 173 19 -
PSLPTPPTR Q28189 151 19 -
PSLPTPPTR Q28188 151 19 -
PSLPTPPTR Q28187 220 19 -
PSLPTPPTR Q28186 169 19 -
PSLPTPPTR Q28185 173 19 -
PSLPTPPTR Q63567 458 19 -
PSLPTPPTR Q63677 146 19 -
PSLPTPPTR TAU_RAT 204 19 -
PSLPTPPTR Q60684 202 19 -
PSLPTPPTR Q60685 144 19 -
PSLPTPPTR Q60686 122 19 -
PSLPTPPTR TAU2_MOUSE 144 19 -
PSLPTPPTR TAU3_MOUSE 144 19 -

Motif 5 width=8
Element Seqn Id St Int Rpt
EPKKVAVV O02828 183 0 -
EPKKVAVV TAU_HUMAN 222 0 -
EPKKVAVV TAU3_BOVIN 183 0 -
EPKKVAVV TAU1_BOVIN 229 0 -
EPKKVAVV Q28190 182 0 -
EPKKVAVV Q28189 160 0 -
EPKKVAVV Q28188 160 0 -
EPKKVAVV Q28187 229 0 -
EPKKVAVV Q28186 178 0 -
EPKKVAVV Q28185 182 0 -
EPKKVAVV Q63567 467 0 -
EPKKVAVV Q63677 155 0 -
EPKKVAVV TAU_RAT 213 0 -
EPKKVAVV Q60684 211 0 -
EPKKVAVV Q60685 153 0 -
EPKKVAVV Q60686 131 0 -
EPKKVAVV TAU2_MOUSE 153 0 -
EPKKVAVV TAU3_MOUSE 153 0 -

Motif 6 width=10
Element Seqn Id St Int Rpt
QAAPGPMPDL O02828 205 14 -
QTAPVPMPDL TAU_HUMAN 244 14 -
QAAPGPMPDL TAU3_BOVIN 205 14 -
QAAPGPMPDL TAU1_BOVIN 251 14 -
QAAPGPMPDL Q28190 204 14 -
QAAPGPMPDL Q28189 182 14 -
QAAPGPMPDL Q28188 182 14 -
QAAPGPMPDL Q28187 251 14 -
QAAPGPMPDL Q28186 200 14 -
QAAPGPMPDL Q28185 204 14 -
QTAPVPMPDL Q63567 489 14 -
QTAPVPMPDL Q63677 177 14 -
QTAPVPMPDL TAU_RAT 235 14 -
QTAPVPMPDL Q60684 233 14 -
QTAPVPMPDL Q60685 175 14 -
QTAPVPMPDL Q60686 153 14 -
QTAPVPMPDL TAU2_MOUSE 175 14 -
QTAPVPMPDL TAU3_MOUSE 175 14 -