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PR01168

Identifier
ALCDHDRGNASE  [View Relations]  [View Alignment]  
Accession
PR01168
No. of Motifs
6
Creation Date
26-AUG-1999
Title
Insect alcohol dehydrogenase signature
Database References
PRINTS; PR00080 SDRFAMILY; PR01167 INSADHFAMILY
INTERPRO; IPR002425
PDB; 1A4U
Literature References
1. VILLARROYA, A., JUAN, E., EGESTAD, B. AND JORNVALL, H.
The primary structure of alcohol dehydrogenase from Drosophila lebanonensis.
Extensive variation within insect 'short-chain' alcohol dehydrogenase 
lacking zinc.
EUR.J.BIOCHEMISTRY 180 191-197 (1989). 
 
2. BENACH, J., ATRIAN, S., GONZALEZ-DUARTE, R. AND LADENSTEIN, R.
The refined crystal structure of Drosophila lebanonensis alcohol
dehydrogenase at 1.9A resolution. 
J.MOL.BIOL. 282 383-399 (1998). 

Documentation
Drosophila alcohol dehydrogenase (ADH), an NAD(H)-dependent oxidoreductase,
is a member of the short-chain dehydrogenases/reductases (SDR) family. The
enzyme is homodimeric and catalyses the dehydrogenation of alcohols to their
respective ketones or aldehydes, both for metabolic assimilation and
detoxification purposes. 
 
Insect ADH is very different from yeast and mammalian ADHs. The enzyme from 
Drosophila lebanonensis has been characterised by protein analysis and was
found to have a 254-residue protein chain with an acetyl-blocked N-terminal
Met [1]. Comparisons with the enzyme from other species reveals that they
have diverged considerably. The structural variation within Drosophila is 
about as large as that for mammalian zinc-containing alcohol dehydrogenase.
 
The crystal structure of the apo form of Drosophila ADH has been solved to
1.9A resolution [2]. Each ADH subunit is revealed to have a mono-domain 
alpha/beta structure, with a characteristic NAD(H)-binding Rossmann fold.
The polypeptide chain folds into a central 8-stranded beta-sheet, flanked 
on each side by 3 alpha-helices. The dimers have local 2-fold symmetry and
essentially associate via a 4-helix bundle. Three structural features 
characterise the active site architecture: (i) a deep cavity, covered by a
flexible 33-residue loop and an 11-residue C-terminal tail of the 
neighbouring subunit, whose hydrophobic surface is likely to increase the
specificity of the enzyme for secondary aliphatic alcohols; (ii) the 
Ser-Tyr-Lys residues of the catalytic triad are known to be involved in
enzymatic catalysis; and (iii) 3 well-ordered water molecules in hydrogen 
bonding distance of side-chains of the catalytic triad may be significant
for the proton release steps in the catalysis. 
 
ALCDHDRGNASE is a 6-element fingerprint that provides a signature for insect
alcohol dehydrogenases. The fingerprint was derived from an initial
alignment of 13 sequences. The motifs were drawn from short conserved 
regions spanning virtually the full alignment length, focusing on those 
sections that characterise the ADHs but distinguish them from the rest of
the SDR family: motif 1 spans the loop between strand 2 and helix 2; motif 2
encodes strand 3; motif 3 spans helices 5 and 6; motif 4 encodes the C-
terminus of helix 9 and strand 6; motif 5 spans strand 8 and helix 12; and
motif 6 encodes strands 9 and 10. Two iterations on SPTR37_10f were required
to reach convergence, at which point a true set comprising 63 sequences was
identified. Several partial matches were also found: a subset of ADH-related
proteins match 3 motifs, and the development-specific 25Kd protein from
Sarcophaga peregrina matches 2 motifs.
Summary Information
  63 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
7 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
6636363636363
5000000
4000000
3007077
2002020
123456
True Positives
ADH1_CERCA    ADH1_DROHY    ADH1_DROMN    ADH1_DROMO    
ADH1_DROMT ADH1_DROMU ADH1_DRONA ADH2_CERCA
ADH2_DROAR ADH2_DROBU ADH2_DROHY ADH2_DROMN
ADH2_DROMO ADH2_DROMU ADH2_DROMY ADH2_DROWH
ADH_DROAD ADH_DROAF ADH_DROAM ADH_DROBO
ADH_DROCR ADH_DRODI ADH_DROER ADH_DROFL
ADH_DROGR ADH_DROGU ADH_DROHA ADH_DROHE
ADH_DROIM ADH_DROLA ADH_DROLE ADH_DROMA
ADH_DROMD ADH_DROME ADH_DROMM ADH_DRONI
ADH_DROOR ADH_DROPE ADH_DROPI ADH_DROPL
ADH_DROPS ADH_DROSI ADH_DROSL ADH_DROSU
ADH_DROTE ADH_DROTS ADH_DROWI ADH_DROYA
ADH_SCAAL ADH_ZAPTU O16093 O96925
O96926 Q26653 Q27332 Q27406
Q27431 Q27595 Q27613 Q27632
Q94461 Q94462 Q95092
True Positive Partials
Codes involving 3 elements
ADHR_DROAM ADHR_DROGU ADHR_DROIM ADHR_DROLE
ADHR_DROMD ADHR_DROME ADHR_DROPS
Codes involving 2 elements
25KD_SARPE ADHR_DROSU
Sequence Titles
ADH1_CERCA  ALCOHOL DEHYDROGENASE 1 (EC 1.1.1.1) - CERATITIS CAPITATA (MEDITERRANEAN FRUIT F 
ADH1_DROHY ALCOHOL DEHYDROGENASE 1 (EC 1.1.1.1) - DROSOPHILA HYDEI (FRUIT FLY).
ADH1_DROMN ALCOHOL DEHYDROGENASE 1 (EC 1.1.1.1) - DROSOPHILA MONTANA (FRUIT FLY).
ADH1_DROMO ALCOHOL DEHYDROGENASE 1 (EC 1.1.1.1) - DROSOPHILA MOJAVENSIS (FRUIT FLY).
ADH1_DROMT ALCOHOL DEHYDROGENASE 1 (EC 1.1.1.1) - DROSOPHILA METTLERI (FRUIT FLY).
ADH1_DROMU ALCOHOL DEHYDROGENASE 1 (EC 1.1.1.1) - DROSOPHILA MULLERI (FRUIT FLY).
ADH1_DRONA ALCOHOL DEHYDROGENASE 1 (EC 1.1.1.1) - DROSOPHILA NAVOJOA (FRUIT FLY).
ADH2_CERCA ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - CERATITIS CAPITATA (MEDITERRANEAN FRUIT F
ADH2_DROAR ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - DROSOPHILA ARIZONAE (FRUIT FLY).
ADH2_DROBU ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - DROSOPHILA BUZZATII (FRUIT FLY).
ADH2_DROHY ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - DROSOPHILA HYDEI (FRUIT FLY).
ADH2_DROMN ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - DROSOPHILA MONTANA (FRUIT FLY).
ADH2_DROMO ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - DROSOPHILA MOJAVENSIS (FRUIT FLY).
ADH2_DROMU ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - DROSOPHILA MULLERI (FRUIT FLY).
ADH2_DROMY ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - DROSOPHILA MAYAGUANA (FRUIT FLY).
ADH2_DROWH ALCOHOL DEHYDROGENASE 2 (EC 1.1.1.1) - DROSOPHILA WHEELERI (FRUIT FLY).
ADH_DROAD ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA ADIASTOLA (FRUIT FLY) (IDIOMYIA
ADH_DROAF ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA AFFINIDISJUNCTA (FRUIT FLY) (IDI
ADH_DROAM ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA AMBIGUA (FRUIT FLY).
ADH_DROBO ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA BOREALIS (FRUIT FLY).
ADH_DROCR ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA CRASSIFEMUR (FRUIT FLY).
ADH_DRODI ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA DIFFERENS (FRUIT FLY).
ADH_DROER ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA ERECTA (FRUIT FLY).
ADH_DROFL ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA FLAVOMONTANA (FRUIT FLY).
ADH_DROGR ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA GRIMSHAWI (FRUIT FLY) (IDIOMYIA
ADH_DROGU ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA GUANCHE (FRUIT FLY).
ADH_DROHA ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA HAWAIIENSIS (FRUIT FLY).
ADH_DROHE ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA HETERONEURA (FRUIT FLY).
ADH_DROIM ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA IMMIGRANS (FRUIT FLY).
ADH_DROLA ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA LACICOLA (FRUIT FLY).
ADH_DROLE ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA LEBANONENSIS (FRUIT FLY) (SCAPTO
ADH_DROMA ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA MAURITIANA (FRUIT FLY).
ADH_DROMD ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA MADEIRENSIS (FRUIT FLY).
ADH_DROME ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA MELANOGASTER (FRUIT FLY).
ADH_DROMM ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA MIMICA (FRUIT FLY) (IDIOMYIA MIM
ADH_DRONI ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA NIGRA (FRUIT FLY) (IDIOMYIA NIGR
ADH_DROOR ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA ORENA (FRUIT FLY).
ADH_DROPE ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA PERSIMILIS (FRUIT FLY).
ADH_DROPI ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA PICTICORNIS (FRUIT FLY) (IDIOMYI
ADH_DROPL ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA PLANITIBIA (FRUIT FLY).
ADH_DROPS ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA PSEUDOOBSCURA (FRUIT FLY).
ADH_DROSI ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA SIMULANS (FRUIT FLY), AND DROSOP
ADH_DROSL ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA SILVESTRIS (FRUIT FLY).
ADH_DROSU ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA SUBOBSCURA (FRUIT FLY).
ADH_DROTE ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA TEISSIERI (FRUIT FLY).
ADH_DROTS ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA TSACASI (FRUIT FLY).
ADH_DROWI ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA WILLISTONI (FRUIT FLY).
ADH_DROYA ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA YAKUBA (FRUIT FLY).
ADH_SCAAL ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - SCAPTOMYZA ALBOVITTATA.
ADH_ZAPTU ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - ZAPRIONUS TUBERCULATUS.
O16093 ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA PERSIMILIS (FRUIT FLY).
O96925 ALCOHOL DEHYDROGENASE - DROSOPHILA TROPICALIS (FRUIT FLY).
O96926 ALCOHOL DEHYDROGENASE - DROSOPHILA NEBULOSA (FRUIT FLY).
Q26653 ALCOHOL DEHYDROGENASE (EC 1.1.1.-) (ADH) - SARCOPHAGA PEREGRINA (FLESH FLY).
Q27332 ALCOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q27406 ALCOHOL DEHYDROGENASE - DROSOPHILA AMERICANA (FRUIT FLY), DROSOPHILA AMERICANA T
Q27431 ALCOHOL DEHYDROGENASE - DROSOPHILA VIRILIS (FRUIT FLY).
Q27595 ALCOHOL DEHYDROGENASE (EC 1.1.1.1) (ALDEHYDE REDUCTASE) - DROSOPHILA MIRANDA (FR
Q27613 ALCOHOL DEHYDROGENASE (EC 1.1.1.1) (ALDEHYDE REDUCTASE) - DROSOPHILA PSEUDOOBSCU
Q27632 ALCHOHOL DEHYDROGENASE (EC 1.1.1.1) - DROSOPHILA SUBOBSCURA (FRUIT FLY).
Q94461 ALCOHOL DEHYDROGENASE 2 - DROSOPHILA BUZZATII (FRUIT FLY).
Q94462 ALCOHOL DEHYDROGENASE 1 - DROSOPHILA BUZZATII (FRUIT FLY).
Q95092 ALCOHOL DEHYDROGENASE (EC 1.1.1.1) (ALDEHYDE REDUCTASE) - DROSOPHILA PSEUDOOBSCU

ADHR_DROAM ALCOHOL DEHYDROGENASE RELATED 31 KD PROTEIN - DROSOPHILA AMBIGUA (FRUIT FLY).
ADHR_DROGU ALCOHOL DEHYDROGENASE RELATED 31 KD PROTEIN - DROSOPHILA GUANCHE (FRUIT FLY).
ADHR_DROIM ALCOHOL DEHYDROGENASE RELATED 31 KD PROTEIN - DROSOPHILA IMMIGRANS (FRUIT FLY).
ADHR_DROLE ALCOHOL DEHYDROGENASE RELATED 31 KD PROTEIN - DROSOPHILA LEBANONENSIS (FRUIT FLY
ADHR_DROMD ALCOHOL DEHYDROGENASE RELATED 31 KD PROTEIN - DROSOPHILA MADEIRENSIS (FRUIT FLY)
ADHR_DROME ALCOHOL DEHYDROGENASE RELATED 31 KD PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY
ADHR_DROPS ALCOHOL DEHYDROGENASE RELATED 31 KD PROTEIN - DROSOPHILA PSEUDOOBSCURA (FRUIT FL

25KD_SARPE DEVELOPMENT-SPECIFIC 25 KD PROTEIN - SARCOPHAGA PEREGRINA (FLESH FLY).
ADHR_DROSU ALCOHOL DEHYDROGENASE RELATED 31 KD PROTEIN - DROSOPHILA SUBOBSCURA (FRUIT FLY).
Scan History
SPTR37_10f 2  350  NSINGLE    
Initial Motifs
Motif 1  width=9
Element Seqn Id St Int Rpt
DRIDNPAAI ADH1_DROHY 36 36 -
DRIENPAAI ADH_DROME 38 38 -
DRIDNPAAI ADH_DROHE 36 36 -
DRIDNPAAI ADH_DRONI 36 36 -
DRIDNPAAI ADH_DROPS 36 36 -
DRIDNPAAI ADH_DROWI 37 37 -
DRIENPAAI ADH_DROIM 36 36 -
DRVENPAAI ADH_ZAPTU 39 39 -
DRIENPAAI ADH_SCAAL 37 37 -
DRAPNPAAI ADH_DROCR 37 37 -
DRVENPTAL ADH_DROLE 37 37 -
DVLDKPEAI ADH1_CERCA 37 37 -
DVLDKPENI ADH2_CERCA 37 37 -

Motif 2 width=11
Element Seqn Id St Int Rpt
PKVTVTFYPYD ADH1_DROHY 52 7 -
PKVTVTFYPYD ADH_DROME 54 7 -
PKVTITFYPYD ADH_DROHE 52 7 -
PKVTVTFYSYD ADH_DRONI 52 7 -
PKVTITFYPYD ADH_DROPS 52 7 -
PKVTVTFYPYD ADH_DROWI 53 7 -
PKVTVTFYPYD ADH_DROIM 52 7 -
PKVTVTFYPYD ADH_ZAPTU 55 7 -
PNVTVSFYPYD ADH_SCAAL 53 7 -
PKVTVSFYLYD ADH_DROCR 53 7 -
PKVNITFHTYD ADH_DROLE 53 7 -
PKTKVYYTKFD ADH1_CERCA 53 7 -
PKTKVYYTKFD ADH2_CERCA 53 7 -

Motif 3 width=19
Element Seqn Id St Int Rpt
NTTTAIMAFWDKRKGGPGG ADH1_DROHY 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROME 114 49 -
NTTTAIMDFWDKRKGGPGG ADH_DROHE 112 49 -
NTTTAIMDFWDKRKGGPGG ADH_DRONI 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROPS 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROWI 113 49 -
NTTTAIMDFWDKRKGGPGG ADH_DROIM 112 49 -
NTTTAILQFWDKRKGGPGG ADH_ZAPTU 115 49 -
NTTTAIMEFWDKRKGGPGG ADH_SCAAL 113 49 -
NTTTAIMEFWDKRKGGPGG ADH_DROCR 113 49 -
NTTTAILDFWDKRKGGPGG ADH_DROLE 113 49 -
NTTLEALPLMDKNKHGRGG ADH1_CERCA 112 48 -
NTTLEGLPLMDKNKQGRGG ADH2_CERCA 112 48 -

Motif 4 width=11
Element Seqn Id St Int Rpt
ITGVTAYSINP ADH1_DROHY 170 39 -
ITGVTAYTVNP ADH_DROME 172 39 -
ITGVTVYSINP ADH_DROHE 170 39 -
ITGVTAYSINP ADH_DRONI 170 39 -
ITGVTAYTVNP ADH_DROPS 170 39 -
VTGVTAFTVNP ADH_DROWI 171 39 -
ITGVIAYSINP ADH_DROIM 170 39 -
ITGVTAYSINP ADH_ZAPTU 173 39 -
ITGVTVYSINP ADH_SCAAL 171 39 -
ITGVTVYSINP ADH_DROCR 171 39 -
ITGVTAYSINP ADH_DROLE 171 39 -
HTGVAVVTFCP ADH1_CERCA 172 41 -
ITGVAVVTFCP ADH2_CERCA 172 41 -

Motif 5 width=16
Element Seqn Id St Int Rpt
TQTSLQCAQNFVKAIE ADH1_DROHY 210 29 -
TQPSLACAENFVKAIE ADH_DROME 212 29 -
TQTTLQCAQNFVKAIE ADH_DROHE 210 29 -
TQTTVQCAQNFVKAIE ADH_DRONI 210 29 -
TQTSQQCAENFVKAIE ADH_DROPS 210 29 -
TQTTLACAQNFVKAIE ADH_DROWI 211 29 -
TQTTTQCSQNFVKAIE ADH_DROIM 210 29 -
TQSTTACAQNFVKAIE ADH_ZAPTU 213 29 -
TQTSLACAKNFVRAIE ADH_SCAAL 211 29 -
TQTSLACAKNFVKAIE ADH_DROCR 211 29 -
TQTSEQCGQNFVKAIE ADH_DROLE 211 29 -
TQKPEVCGAHLAQAIE ADH1_CERCA 214 31 -
TQKPEVCGAHLAQVVE ADH2_CERCA 214 31 -

Motif 6 width=14
Element Seqn Id St Int Rpt
GAIWKLDLGRLEAI ADH1_DROHY 230 4 -
GAIWKLDLGTLEAI ADH_DROME 232 4 -
GAIWKLDLGRLDAI ADH_DROHE 230 4 -
GAIWQLDLGRLEAI ADH_DRONI 230 4 -
GAIWKLDLGTLEPI ADH_DROPS 230 4 -
GAIWKLDLGTLEPI ADH_DROWI 231 4 -
GAIWKLDLGRLDAV ADH_DROIM 230 4 -
GAIWKLDVGRLDPV ADH_ZAPTU 233 4 -
GAIWKLDLNRLDEI ADH_SCAAL 231 4 -
GAIWKLDLGRLDEI ADH_DROCR 231 4 -
GAIWKLDLGTLEAI ADH_DROLE 231 4 -
GAIYISNQGTLTKV ADH1_CERCA 234 4 -
GGIYISNQGTLAKV ADH2_CERCA 234 4 -
Final Motifs
Motif 1  width=9
Element Seqn Id St Int Rpt
DRIENPAAI ADH2_DROAR 36 36 -
DRIENPAAI ADH2_DROMU 36 36 -
DRIDNPAAI ADH1_DROHY 36 36 -
DRIENPAAI ADH2_DROBU 36 36 -
DRIENPAAI Q94461 37 37 -
DRIENPAAI ADH1_DRONA 36 36 -
DRIENPAAI ADH2_DROWH 36 36 -
DRIDNPAAI ADH_DROHA 36 36 -
DRIDNPAAI ADH_DROAD 36 36 -
DRIDNPAAI ADH_DROPI 36 36 -
DRIENPAAI ADH2_DROMO 36 36 -
DRIENPAAI ADH_DROER 38 38 -
DRIENPAAI ADH1_DROMU 36 36 -
DRVDNPAAI ADH_DROAF 36 36 -
DRVDNPAAI ADH_DRODI 36 36 -
DRVDNPAAI ADH_DROPL 36 36 -
DRIDNPAAI ADH2_DROHY 36 36 -
DRIENPAAI ADH2_DROMY 36 36 -
DRIENPAAI ADH_DROYA 38 38 -
DRIDNPAAI Q27595 37 37 -
DRIDNPAAI ADH_DROGU 36 36 -
DRIDNPAAI ADH_DROMD 36 36 -
DRIENPAAI ADH_DROME 38 38 -
DRIENPAAI ADH_DROSI 38 38 -
DRIENPAAI ADH_DROTE 38 38 -
DRIDNPAAI ADH_DROHE 36 36 -
DRVDNPAAI ADH_DROGR 36 36 -
DRIDNPAAI ADH_DRONI 36 36 -
DRIENPAAI ADH1_DROMO 36 36 -
DRIDNPAAI ADH_DROPE 36 36 -
DRIDNPAAI ADH_DROPS 36 36 -
DRIDNPAAI O16093 36 36 -
DRIDNPAAI Q27613 37 37 -
DRIDNPAAI Q95092 37 37 -
DRIDNPAAI ADH_DROAM 37 37 -
DRIDNPAAI ADH_DROSL 36 36 -
DRIENPAAI ADH_DROOR 38 38 -
DRIENPAAI ADH_DROMA 38 38 -
DRIENPAAI Q94462 37 37 -
DRIDNPAAI ADH_DROMM 36 36 -
DRIENPAVI Q27332 38 38 -
DRIDNAAAI Q27632 37 37 -
DRIDNPAAI ADH_DROTS 39 39 -
DRIDNPAAI O96925 37 37 -
DRIDNPAAI ADH_DROWI 37 37 -
DRVENPTAI ADH1_DROMT 36 36 -
DRIENPAAI ADH_DROIM 36 36 -
DRIDNPTAI ADH_DROLA 37 37 -
DRIDNPTAI ADH_DROFL 36 36 -
DRIDNPTAI ADH_DROBO 36 36 -
DRIDNPTAI ADH2_DROMN 36 36 -
DRIDNPTAI ADH1_DROMN 36 36 -
DRIENPTAI Q27406 37 37 -
DRIENPTAI Q27431 37 37 -
DRVENPAAI ADH_ZAPTU 39 39 -
DRIDNPDAI ADH_DROSU 37 37 -
DRTDNPAAI O96926 37 37 -
DRIENPAAI ADH_SCAAL 37 37 -
DRAPNPAAI ADH_DROCR 37 37 -
DRVENPTAL ADH_DROLE 37 37 -
DVLDKPEAI ADH1_CERCA 37 37 -
DVLDKPENI ADH2_CERCA 37 37 -
DVVENPKAV Q26653 37 37 -

Motif 2 width=11
Element Seqn Id St Int Rpt
PKVTVTFYPYD ADH2_DROAR 52 7 -
PKVTVTFYPYD ADH2_DROMU 52 7 -
PKVTVTFYPYD ADH1_DROHY 52 7 -
PKVTVTFYPYD ADH2_DROBU 52 7 -
PKVTVTFYPYD Q94461 53 7 -
PKVTVTFYPYD ADH1_DRONA 52 7 -
PKVTVTFYPYD ADH2_DROWH 52 7 -
PKVTVTFYPYD ADH_DROHA 52 7 -
PKVTVTFYPYD ADH_DROAD 52 7 -
PKVTITFYPYD ADH_DROPI 52 7 -
PKVTVTFYPYD ADH2_DROMO 52 7 -
PKVTVTFYPYD ADH_DROER 54 7 -
PNVTVTFYPYD ADH1_DROMU 52 7 -
PKVTVTFYPYD ADH_DROAF 52 7 -
PKVTVTFYPYD ADH_DRODI 52 7 -
PKVTVTFYPYD ADH_DROPL 52 7 -
PKVTITFYPYD ADH2_DROHY 52 7 -
PKVIVTFYPYD ADH2_DROMY 52 7 -
PKVTVTFYPYD ADH_DROYA 54 7 -
PKVTVTFYPYD Q27595 53 7 -
PKVTVTFYPYD ADH_DROGU 52 7 -
PKVTVTFYPYD ADH_DROMD 52 7 -
PKVTVTFYPYD ADH_DROME 54 7 -
PKVTVTFYPYD ADH_DROSI 54 7 -
PKVTVTFYPYD ADH_DROTE 54 7 -
PKVTITFYPYD ADH_DROHE 52 7 -
PKVTITFYPYD ADH_DROGR 52 7 -
PKVTVTFYSYD ADH_DRONI 52 7 -
PKVTVTFYLYD ADH1_DROMO 52 7 -
PKVTITFYPYD ADH_DROPE 52 7 -
PKVTITFYPYD ADH_DROPS 52 7 -
PKVTITFYPYD O16093 52 7 -
PKVTITFYPYD Q27613 53 7 -
PKVTITFYPYD Q95092 53 7 -
PKVTVTFYPYD ADH_DROAM 53 7 -
PKVTITFYPYD ADH_DROSL 52 7 -
PKVTVTFYPYD ADH_DROOR 54 7 -
PKVTVTFYPYD ADH_DROMA 54 7 -
PNVTVTFYTYD Q94462 53 7 -
PKVTVTFYPYD ADH_DROMM 52 7 -
PKVTVTFYPYD Q27332 54 7 -
PKVTVTFYPYD Q27632 53 7 -
PKVTVTFYPYD ADH_DROTS 55 7 -
PKVTVTFYPYD O96925 53 7 -
PKVTVTFYPYD ADH_DROWI 53 7 -
PKVTITFYPYD ADH1_DROMT 52 7 -
PKVTVTFYPYD ADH_DROIM 52 7 -
PKVTVTFYPYD ADH_DROLA 53 7 -
PKVTVTFYPYD ADH_DROFL 52 7 -
PKVTVTFYPYD ADH_DROBO 52 7 -
PKVTVTFYPYD ADH2_DROMN 52 7 -
PKVTVTFYPYD ADH1_DROMN 52 7 -
PKVTVTFYPYD Q27406 53 7 -
PKVTVTFYPYD Q27431 53 7 -
PKVTVTFYPYD ADH_ZAPTU 55 7 -
PKVTVTFFPYD ADH_DROSU 53 7 -
PKVTVTFYPYD O96926 53 7 -
PNVTVSFYPYD ADH_SCAAL 53 7 -
PKVTVSFYLYD ADH_DROCR 53 7 -
PKVNITFHTYD ADH_DROLE 53 7 -
PKTKVYYTKFD ADH1_CERCA 53 7 -
PKTKVYYTKFD ADH2_CERCA 53 7 -
PKTKVVYMKFD Q26653 53 7 -

Motif 3 width=19
Element Seqn Id St Int Rpt
NTTTAIMSFWDKRKGGPGG ADH2_DROAR 112 49 -
NTTTAIMSFWDKRKGGPGG ADH2_DROMU 112 49 -
NTTTAIMAFWDKRKGGPGG ADH1_DROHY 112 49 -
NTTTAIMAFWDKRKGGPGG ADH2_DROBU 112 49 -
NTTTAIMAFWDKRKGGPGG Q94461 113 49 -
NTTTAIMSFWDKRKGGPGG ADH1_DRONA 112 49 -
NTTTAIMSFWDKRKGGPGG ADH2_DROWH 112 49 -
NTTTAILDFWDKRKGGPVG ADH_DROHA 112 49 -
NTTTAIMDFWDKRKGGPGG ADH_DROAD 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROPI 112 49 -
NTTTAIMSFWDKRKGGPGG ADH2_DROMO 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROER 114 49 -
NTTTAIMSFWDKRKGGPGG ADH1_DROMU 112 49 -
NTTTAIMDFWDKRKGGPGG ADH_DROAF 112 49 -
NTTTAIMDFWDKRKGGPGG ADH_DRODI 112 49 -
NTTTAIMDFWDKRKGGPGG ADH_DROPL 112 49 -
NTTTAIMAFWDKRKGGPGG ADH2_DROHY 112 49 -
NTTTAIMSFWDKRKGGPGG ADH2_DROMY 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROYA 114 49 -
NTTTAILDFWDKRKGGPGG Q27595 113 49 -
NTTTAILDFWDKRKGGPGG ADH_DROGU 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROMD 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROME 114 49 -
NTTTAILDFWDKRKGGPGG ADH_DROSI 114 49 -
NTTTAILDFWDKRKGGPGG ADH_DROTE 114 49 -
NTTTAIMDFWDKRKGGPGG ADH_DROHE 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROGR 112 49 -
NTTTAIMDFWDKRKGGPGG ADH_DRONI 112 49 -
NTITAIMSFWDKRKGGPGG ADH1_DROMO 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROPE 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROPS 112 49 -
NTTTAILDFWDKRKGGPGG O16093 112 49 -
NTTTAILDFWDKRKGGPGG Q27613 113 49 -
NTTTAILDFWDKRKGGPGG Q95092 113 49 -
NTTTAILDFWDKRKGGPGG ADH_DROAM 113 49 -
NTTTAIMDFWDKRNGGPGG ADH_DROSL 112 49 -
NTTTAILDFWDKRKGGPGG ADH_DROOR 114 49 -
NTTTAILDFWDKRKGGPGG ADH_DROMA 114 49 -
NTTTAIMSFWDKRKGGPGG Q94462 113 49 -
NTTTAIMDFWDKRNGGPGG ADH_DROMM 112 49 -
NTTTAILDFWDKRKGGPGG Q27332 114 49 -
NTTTAILDFWDKRKGGPGG Q27632 113 49 -
NTTTAILDFWDKRKGGPGG ADH_DROTS 115 49 -
NTTTAILDFWDKRKGGPGG O96925 113 49 -
NTTTAILDFWDKRKGGPGG ADH_DROWI 113 49 -
NTTTAIMAFWDKRKGGPGG ADH1_DROMT 112 49 -
NTTTAIMDFWDKRKGGPGG ADH_DROIM 112 49 -
NTTTAIMEFWDKRKGGPGG ADH_DROLA 113 49 -
NTTTAIMEFWDKRKGGPGG ADH_DROFL 112 49 -
NTTTAIMEFWDKRKGGPGG ADH_DROBO 112 49 -
NTTTAIMEFWDKRKGGPGG ADH2_DROMN 112 49 -
NTTTAIMEFWDKRKGGPGG ADH1_DROMN 112 49 -
NTTTAIMEFWDKRKGGPGG Q27406 113 49 -
NTTTAIMEFWDKRKGGPGG Q27431 113 49 -
NTTTAILQFWDKRKGGPGG ADH_ZAPTU 115 49 -
NTTTAILDFWDKRKCGPGG ADH_DROSU 113 49 -
NTTTAILDFWDKRKGGPGG O96926 113 49 -
NTTTAIMEFWDKRKGGPGG ADH_SCAAL 113 49 -
NTTTAIMEFWDKRKGGPGG ADH_DROCR 113 49 -
NTTTAILDFWDKRKGGPGG ADH_DROLE 113 49 -
NTTLEALPLMDKNKHGRGG ADH1_CERCA 112 48 -
NTTLEGLPLMDKNKQGRGG ADH2_CERCA 112 48 -
NTTMEALPYMDKTQKGRGG Q26653 112 48 -

Motif 4 width=11
Element Seqn Id St Int Rpt
ITGVTAYSINP ADH2_DROAR 170 39 -
ITGVTAYSINP ADH2_DROMU 170 39 -
ITGVTAYSINP ADH1_DROHY 170 39 -
ITGVTAYSINP ADH2_DROBU 170 39 -
ITGVTAYSINP Q94461 171 39 -
ITGVTAYSINP ADH1_DRONA 170 39 -
ITGVTAYSINP ADH2_DROWH 170 39 -
ITGVTAYSINP ADH_DROHA 170 39 -
ITGVTAYSINP ADH_DROAD 170 39 -
ITGVTAYSINP ADH_DROPI 170 39 -
ITGVTAYSINP ADH2_DROMO 170 39 -
ITGVTAYTVNP ADH_DROER 172 39 -
ITGVTAYSINP ADH1_DROMU 170 39 -
ITGVTAYSINP ADH_DROAF 170 39 -
ITGVTAYSINP ADH_DRODI 170 39 -
ITGVTAYSINP ADH_DROPL 170 39 -
ITGVTAYSINP ADH2_DROHY 170 39 -
ITGVTAYSINP ADH2_DROMY 170 39 -
ITGVTAYTVNP ADH_DROYA 172 39 -
ITGVTAYTVNP Q27595 171 39 -
ITGVTAYTVNP ADH_DROGU 170 39 -
ITGVTAYTVNP ADH_DROMD 170 39 -
ITGVTAYTVNP ADH_DROME 172 39 -
ITGVTAYTVNP ADH_DROSI 172 39 -
ITGVTAYTVNP ADH_DROTE 172 39 -
ITGVTVYSINP ADH_DROHE 170 39 -
ITGVTAYSINP ADH_DROGR 170 39 -
ITGVTAYSINP ADH_DRONI 170 39 -
ITGVTAYSINP ADH1_DROMO 170 39 -
ITGVTAYTVNP ADH_DROPE 170 39 -
ITGVTAYTVNP ADH_DROPS 170 39 -
ITGVTAYTVNP O16093 170 39 -
ITGVTAYTVNP Q27613 171 39 -
ITGVTAYTVNP Q95092 171 39 -
ITGVTAYTVNP ADH_DROAM 171 39 -
ITGVTVYSINP ADH_DROSL 170 39 -
ITGVTAYTVNP ADH_DROOR 172 39 -
ITGVTAYTVNP ADH_DROMA 172 39 -
ITGVTAYSINP Q94462 171 39 -
VTGVTAYSINP ADH_DROMM 170 39 -
ITGVTAYTVNP Q27332 172 39 -
ITGVTAYTVNP Q27632 171 39 -
ITGVTAYTVNP ADH_DROTS 173 39 -
VTGVTAFTVNP O96925 171 39 -
VTGVTAFTVNP ADH_DROWI 171 39 -
ITGVTAYSINP ADH1_DROMT 170 39 -
ITGVIAYSINP ADH_DROIM 170 39 -
ITGVTAYSINP ADH_DROLA 171 39 -
ITGVTAYSINP ADH_DROFL 170 39 -
ITGVTAYSINP ADH_DROBO 170 39 -
ITGVTAYSINP ADH2_DROMN 170 39 -
ITGVTAYSINP ADH1_DROMN 170 39 -
ITGVTAYSINP Q27406 171 39 -
ITGVTAYSINP Q27431 171 39 -
ITGVTAYSINP ADH_ZAPTU 173 39 -
ITGVTAYTVNP ADH_DROSU 171 39 -
ITGVTAFTVNP O96926 171 39 -
ITGVTVYSINP ADH_SCAAL 171 39 -
ITGVTVYSINP ADH_DROCR 171 39 -
ITGVTAYSINP ADH_DROLE 171 39 -
HTGVAVVTFCP ADH1_CERCA 172 41 -
ITGVAVVTFCP ADH2_CERCA 172 41 -
RSGVAVTAICP Q26653 172 41 -

Motif 5 width=16
Element Seqn Id St Int Rpt
TQTTLQCAQNFVKAIE ADH2_DROAR 210 29 -
TQTTLQCAQNFVKAIE ADH2_DROMU 210 29 -
TQTSLQCAQNFVKAIE ADH1_DROHY 210 29 -
TQTTLQCAQNFVKAIE ADH2_DROBU 210 29 -
TQTTLQCAQNFVKAIE Q94461 211 29 -
TQTSLECAQNFVKAIE ADH1_DRONA 210 29 -
TQTRLQCAQNFVKAIE ADH2_DROWH 210 29 -
TQTTLQCAQNFVKAIE ADH_DROHA 210 29 -
TQTTLQCGQNFVKAIE ADH_DROAD 210 29 -
TQTTLQCAQNFVKAIE ADH_DROPI 210 29 -
TQTTLQCAQNFVKAIQ ADH2_DROMO 210 29 -
TQTSLSCAENFVKAIE ADH_DROER 212 29 -
TQTSLQCAQNFVKAIE ADH1_DROMU 210 29 -
TQTTLQCAQNFVKAIE ADH_DROAF 210 29 -
TQTTLQCAQNFVKAIE ADH_DRODI 210 29 -
TQTTLQCAQNFVKAIE ADH_DROPL 210 29 -
TQTTLQCAQNFVKAIE ADH2_DROHY 210 29 -
TQTTLQCAQNFVKAIE ADH2_DROMY 210 29 -
TQPSLACAQNFVKAIE ADH_DROYA 212 29 -
TQTSQQCAENFVKAIE Q27595 211 29 -
TQTSQQCAENFVKAIE ADH_DROGU 210 29 -
TQTSQQCAENFVKAIE ADH_DROMD 210 29 -
TQPSLACAENFVKAIE ADH_DROME 212 29 -
TQPSLACAENFVKAIE ADH_DROSI 212 29 -
TQPSLACAENFVKAIE ADH_DROTE 212 29 -
TQTTLQCAQNFVKAIE ADH_DROHE 210 29 -
TQTTLQCAQNFVKAIE ADH_DROGR 210 29 -
TQTTVQCAQNFVKAIE ADH_DRONI 210 29 -
TQTSLECAQNFVKAIE ADH1_DROMO 210 29 -
TQTSQQCAENFVKAIE ADH_DROPE 210 29 -
TQTSQQCAENFVKAIE ADH_DROPS 210 29 -
TQTSQQCAENFVKAIE O16093 210 29 -
TQTSQQCAENFVKAIE Q27613 211 29 -
TQTSQQCAENFVKAIE Q95092 211 29 -
TQTSQQCAENFVKAIE ADH_DROAM 211 29 -
TQTTLQCAQNFVKAIE ADH_DROSL 210 29 -
IQSSLACAENFVKAIE ADH_DROOR 212 29 -
TQPSLACAENFVKAIE ADH_DROMA 212 29 -
TQTSLECAQNFVKAIE Q94462 211 29 -
TQTTVQCAQNFVKAIE ADH_DROMM 210 29 -
TQPSLACAENFVKAIE Q27332 212 29 -
TQTSQQCAENFVKAIE Q27632 211 29 -
TQPSQACAENFVKAIE ADH_DROTS 213 29 -
TQTTLACAQNFVKAIE O96925 211 29 -
TQTTLACAQNFVKAIE ADH_DROWI 211 29 -
TQTTLQCAQNFVKAIE ADH1_DROMT 210 29 -
TQTTTQCSQNFVKAIE ADH_DROIM 210 29 -
TQTTLECAQNFVKAIE ADH_DROLA 211 29 -
TQTTLECAQNFVKAIE ADH_DROFL 210 29 -
TQTTLECAQNFVKAIE ADH_DROBO 210 29 -
TQTTLECAQNFVKAIE ADH2_DROMN 210 29 -
TQTTLECAQNFVKAIE ADH1_DROMN 210 29 -
TQTTLECAQNFVKAIE Q27406 211 29 -
TQTTLECAQNFVKAIE Q27431 211 29 -
TQSTTACAQNFVKAIE ADH_ZAPTU 213 29 -
TQTTQQCAKNFVKAIE ADH_DROSU 211 29 -
TQTTLACAQNFVKAIE O96926 211 29 -
TQTSLACAKNFVRAIE ADH_SCAAL 211 29 -
TQTSLACAKNFVKAIE ADH_DROCR 211 29 -
TQTSEQCGQNFVKAIE ADH_DROLE 211 29 -
TQKPEVCGAHLAQAIE ADH1_CERCA 214 31 -
TQKPEVCGAHLAQVVE ADH2_CERCA 214 31 -
RQPAAKAGEHLVKIIE Q26653 214 31 -

Motif 6 width=14
Element Seqn Id St Int Rpt
GAIWKLDLGTLEAI ADH2_DROAR 230 4 -
GAIWKLDLGTLEAI ADH2_DROMU 230 4 -
GAIWKLDLGRLEAI ADH1_DROHY 230 4 -
GAIWKLDLGRLEAI ADH2_DROBU 230 4 -
GAIWKLDLGRLEAI Q94461 231 4 -
GAIWKLDLGTLEAI ADH1_DRONA 230 4 -
GAIWKLDLGTLEAI ADH2_DROWH 230 4 -
GAIWKLDLGRLDAI ADH_DROHA 230 4 -
GAIWKLDLGRLDAI ADH_DROAD 230 4 -
GAIWKLDLGRLDAI ADH_DROPI 230 4 -
GAIWKLDLGTLEAI ADH2_DROMO 230 4 -
GAIWKLDLGTLEAI ADH_DROER 232 4 -
GAIWKLDLGTLEAI ADH1_DROMU 230 4 -
GAIWKLDLGRLDAI ADH_DROAF 230 4 -
GAIWKLDLGRLDAI ADH_DRODI 230 4 -
GAIWKLDLGRLDAI ADH_DROPL 230 4 -
GAIWKLDLGRLDAI ADH2_DROHY 230 4 -
GAIWKLDLGRLEAI ADH2_DROMY 230 4 -
GAIWKLDLGTLEAI ADH_DROYA 232 4 -
GAIWKLDLGTLEPI Q27595 231 4 -
GAIWKLDLGTLEPI ADH_DROGU 230 4 -
GAIWKLDLGTLESI ADH_DROMD 230 4 -
GAIWKLDLGTLEAI ADH_DROME 232 4 -
GAIWKLDLGTLEAI ADH_DROSI 232 4 -
GAIWKLDLGTLEAI ADH_DROTE 232 4 -
GAIWKLDLGRLDAI ADH_DROHE 230 4 -
GAIWKLDLGRLDAI ADH_DROGR 230 4 -
GAIWQLDLGRLEAI ADH_DRONI 230 4 -
GAIWKLDLGTLEAI ADH1_DROMO 230 4 -
GAIWKLDLGTLEPI ADH_DROPE 230 4 -
GAIWKLDLGTLEPI ADH_DROPS 230 4 -
GAIWKLDLGTLEPI O16093 230 4 -
GAIWKLDLGTLEPI Q27613 231 4 -
GAIWKLDLGTLEPI Q95092 231 4 -
GAIWNLDLGTLEPI ADH_DROAM 231 4 -
GAIWKLDLGRLDAI ADH_DROSL 230 4 -
GAIWKLDLGTLEAI ADH_DROOR 232 4 -
GAIWKLDLSTLEAI ADH_DROMA 232 4 -
GAIWKLDLGRLEAI Q94462 231 4 -
GAIWKLDLGRLDPI ADH_DROMM 230 4 -
GAIWKLDLGTLEAI Q27332 232 4 -
GAIWKLDLGTLESI Q27632 231 4 -
GAIWKLDRGTLEPI ADH_DROTS 233 4 -
GAIWKLDLGTLEPI O96925 231 4 -
GAIWKLDLGTLEPI ADH_DROWI 231 4 -
GAIWKLDLGRLDAI ADH1_DROMT 230 4 -
GAIWKLDLGRLDAV ADH_DROIM 230 4 -
GAIWQLDLGQLIAV ADH_DROLA 231 4 -
GAIWQLDLGQLIAV ADH_DROFL 230 4 -
GAIWQLDLGQLIAV ADH_DROBO 230 4 -
GAIWQLDLGQLIAV ADH2_DROMN 230 4 -
GAIWQLDLGQLIAV ADH1_DROMN 230 4 -
GAIWQLDLGRLISV Q27406 231 4 -
GAIWQLDLGRLISV Q27431 231 4 -
GAIWKLDVGRLDPV ADH_ZAPTU 233 4 -
GALWKLDLGTLEPI ADH_DROSU 231 4 -
GAIWKLDLGTLEDI O96926 231 4 -
GAIWKLDLNRLDEI ADH_SCAAL 231 4 -
GAIWKLDLGRLDEI ADH_DROCR 231 4 -
GAIWKLDLGTLEAI ADH_DROLE 231 4 -
GAIYISNQGTLTKV ADH1_CERCA 234 4 -
GGIYISNQGTLAKV ADH2_CERCA 234 4 -
GTMWISDRSTLTKV Q26653 234 4 -