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PR01130

Identifier
DERENTRNSPRT  [View Relations]  [View Alignment]  
Accession
PR01130
No. of Motifs
9
Creation Date
21-MAY-1999
Title
Delayed-early response protein/equilibrative nucleoside transporter signature 
Database References

INTERPRO; IPR002259
Literature References
1. WILLIAMS, J.B. AND LANAHAN, A.A.
A mammalian delayed-early response gene encodes HNP36, a novel, conserved
nucleolar protein.
BIOCHEM.BIOPHYS.RES.COMMUN. 213(1) 325-333 (1995).

Documentation
Delayed-early response (DER) gene products include growth progression 
factors and several unknown products of novel cDNAs. Murine and human cDNAs
from one novel DER gene (DER12) have been characterised to identify its 
product and to examine its role in the growth response [1]. Both sequences
encode a hydrophobic 36kD protein that is predicted to contain 8 trans-
membrane (TM) domains. The protein has been localised to the nucleolus,
where its concentration increases following mitogen stimulation [1]. 
 
Although the function fo the protein is unknown, its identification as a 
nucleolar gene transcriptionally activated by growth factors implicates it
as participating in the proliferative response [1]. Sequence analysis
reveals the protein to share a high degree of similarity with the C-terminal
portion of equilibrative nucleoside transporters.
 
DERENTRNSPRT is a 9-element fingerprint that provides a signature for 
delayed-early response proteins, DER12, and equilibrative nucleoside 
transporters. The fingerprint was derived from an initial alignment of
2 sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length: motifs 1-7 and 9 each reside within putative TM
domains. Two iterations on SPTR37_9f were required to reach convergence, at
which point a true set comprising 6 sequences was identified.
Summary Information
6 codes involving  9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
9666666666
8000000000
7000000000
6000000000
5000000000
4000000000
3000000000
2000000000
123456789
True Positives
HN36_HUMAN    HN36_MOUSE    O43530        O54698        
O54699 Q99808
Sequence Titles
HN36_HUMAN  36 KD NUCLEOLAR PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEIN 12) (DER12) - HOMO SAPIENS (HUMAN). 
HN36_MOUSE 36 KD NUCLEOLAR PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEIN 12) (DER12) - MUS MUSCULUS (MOUSE).
O43530 NBMPR-INSENSITIVE NUCLEOSIDE TRANSPORTER EI - HOMO SAPIENS (HUMAN).
O54698 EQUILBRATIVE NITROBENZYLTHIOINOSINE-SENSITIVE NUCLEOSIDE TRANSPORTER - RATTUS NORVEGICUS (RAT).
O54699 EQUILBRATIVE NITROBENZYLTHIOINOSINE-INSENSITIVE NUCLEOSIDE TRANSPORTER - RATTUS NORVEGICUS (RAT).
Q99808 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 - HOMO SAPIENS (HUMAN).
Scan History
SPTR37_9f  2  8    NSINGLE    
Initial Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
INSFCAVLQGSLFGQLGTMPSTY HN36_MOUSE 7 7 -
INSFSAVLQGSLFGQLGTMPSTY HN36_HUMAN 7 7 -

Motif 2 width=21
Element Seqn Id St Int Rpt
SGQGLAGIFAALAMLMSLASG HN36_MOUSE 35 5 -
SGQGLAGIFAALAMLLSMASG HN36_HUMAN 35 5 -

Motif 3 width=24
Element Seqn Id St Int Rpt
SALGYFITPCVGILLSIVCYLSLP HN36_MOUSE 61 5 -
SALGYFITPYVGILMSIVCYLSLP HN36_HUMAN 61 5 -

Motif 4 width=18
Element Seqn Id St Int Rpt
FTVTLSVFPAITAMVTTS HN36_MOUSE 170 85 -
FTVTLSVFPAITAMVTSS HN36_HUMAN 171 86 -

Motif 5 width=22
Element Seqn Id St Int Rpt
CFLLFNVMDWLGRSLTSYFLWP HN36_MOUSE 203 15 -
CFLLFNIMDWLGRSLTSYFLWP HN36_HUMAN 203 14 -

Motif 6 width=18
Element Seqn Id St Int Rpt
LPLLVCLRFLFVPLFMLC HN36_MOUSE 232 7 -
LPLLVCLRFLFVPLFMLC HN36_HUMAN 231 6 -

Motif 7 width=17
Element Seqn Id St Int Rpt
DAYFITFMLLFAVSNGY HN36_MOUSE 264 14 -
DAYFITFMLLFAVSNGY HN36_HUMAN 263 14 -

Motif 8 width=17
Element Seqn Id St Int Rpt
SLTMCLAPRQVLPHERE HN36_MOUSE 283 2 -
SLTMCLAPRQVLPHERE HN36_HUMAN 282 2 -

Motif 9 width=25
Element Seqn Id St Int Rpt
AGALMTFFLALGLSCGASLSFLFKA HN36_MOUSE 301 1 -
AGALMTFFLALGLSCGASLSFLFKA HN36_HUMAN 300 1 -
Final Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
INSFSAVLQGSLFGQLGTMPSTY O43530 137 137 -
INSFCAVLQGSLFGQLGTMPSTY HN36_MOUSE 7 7 -
INSFSAVLQGSLFGQLGTMPSTY HN36_HUMAN 7 7 -
INSFCAVLQGSLFGQLGTMPSTY O54699 136 136 -
INSFGAILQGSLFGLAGLLPASY Q99808 150 150 -
INSFGAILQASLFGLAGVLPANY O54698 150 150 -

Motif 2 width=21
Element Seqn Id St Int Rpt
SGQGLAGIFAALAMLLSMASG O43530 165 5 -
SGQGLAGIFAALAMLMSLASG HN36_MOUSE 35 5 -
SGQGLAGIFAALAMLLSMASG HN36_HUMAN 35 5 -
SGQGLAGIFAALAMLTSLASG O54699 164 5 -
SGQGLAGFFASVAMICAIASG Q99808 178 5 -
SGQGLAGFFTSVAMICAVASG O54698 178 5 -

Motif 3 width=24
Element Seqn Id St Int Rpt
SALGYFITPCVGILMSIVCYLSLP O43530 191 5 -
SALGYFITPCVGILLSIVCYLSLP HN36_MOUSE 61 5 -
SALGYFITPYVGILMSIVCYLSLP HN36_HUMAN 61 5 -
SALGYFITPCVGILLSIICYLSLP O54699 190 5 -
SAFGYFITACAVIILTIICYLGLP Q99808 204 5 -
SAFGYFITACAVVILAILCYLALP O54698 204 5 -

Motif 4 width=18
Element Seqn Id St Int Rpt
FTVTLSVFPAITAMVTSS O43530 301 86 -
FTVTLSVFPAITAMVTTS HN36_MOUSE 170 85 -
FTVTLSVFPAITAMVTSS HN36_HUMAN 171 86 -
FTVTLSVFPAITAMVTTS O54699 300 86 -
FTITIGMFPAVTVEVKSS Q99808 300 72 -
FTVTIGLFPAVTAEVESS O54698 300 72 -

Motif 5 width=22
Element Seqn Id St Int Rpt
CFLLFNIMDWLGRSLTSYFLWP O43530 333 14 -
CFLLFNVMDWLGRSLTSYFLWP HN36_MOUSE 203 15 -
CFLLFNIMDWLGRSLTSYFLWP HN36_HUMAN 203 14 -
CFLLFNVMDWLGRSLTSYFLWP O54699 333 15 -
CFLTFNIFDWLGRSLTAVFMWP Q99808 333 15 -
CFLNFNVFDWLGRSLTAICMWP O54698 334 16 -

Motif 6 width=18
Element Seqn Id St Int Rpt
LPLLVCLRFLFVPLFMLC O43530 361 6 -
LPLLVCLRFLFVPLFMLC HN36_MOUSE 232 7 -
LPLLVCLRFLFVPLFMLC HN36_HUMAN 231 6 -
LPLLVCLRFLFVPLFMLC O54699 361 6 -
LPSLVLARLVFVPLLLLC Q99808 361 6 -
LPVLVACRVVFIPLLMLC O54698 362 6 -

Motif 7 width=17
Element Seqn Id St Int Rpt
DAYFITFMLLFAVSNGY O43530 393 14 -
DAYFITFMLLFAVSNGY HN36_MOUSE 264 14 -
DAYFITFMLLFAVSNGY HN36_HUMAN 263 14 -
DAYFITFMLLFAISNGY O54699 393 14 -
DAWFIFFMAAFAFSNGY Q99808 393 14 -
DVWFITFMAAFAFSNGY O54698 394 14 -

Motif 8 width=17
Element Seqn Id St Int Rpt
SLTMCLAPRQVLPHERE O43530 412 2 -
SLTMCLAPRQVLPHERE HN36_MOUSE 283 2 -
SLTMCLAPRQVLPHERE HN36_HUMAN 282 2 -
SLTMCLAPRQVLPHERE O54699 412 2 -
SLCMCFGPKKVKPAEAE Q99808 412 2 -
SLCMCFGPKKVKPAEAE O54698 413 2 -

Motif 9 width=25
Element Seqn Id St Int Rpt
AGALMTFFLALGLSCGASLSFLFKA O43530 430 1 -
AGALMTFFLALGLSCGASLSFLFKA HN36_MOUSE 301 1 -
AGALMTFFLALGLSCGASLSFLFKA HN36_HUMAN 300 1 -
AGALMTFFLALGLSCGASLSFLFKA O54699 430 1 -
AGAIMAFFLCLGLALGAVFSFLFRA Q99808 430 1 -
AGNIMSFFLCLGLALGAVLSFLLRA O54698 431 1 -