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PR00891

Identifier
RABGDIREP  [View Relations]  [View Alignment]  
Accession
PR00891
No. of Motifs
7
Creation Date
07-JUN-1998  (UPDATE 07-JUN-1999)
Title
Rab GDI/REP protein family signature
Database References
PRINTS; PR00893 RABESCORT; PR00892 RABGDI; PR00894 YEASTMRS6P

PFAM; PF00996 GDI
INTERPRO; IPR002005
PDB; 1GND
SCOP; 1GND
CATH; 1GND
Literature References
1. ALEXANDROV, K., HORIUCHI, H., STEELE-MORTIMER, O., SEABRA, M.C.
AND ZERIAL, M.
RAB escort protein-1 is a multifunctional protein that accompanies newly
prenylated Rab proteins to their target membranes. 
EMBO J. 13 5262-5273 (1994). 
 
2. NISHIMURA, N., GOJI, J., NAKAMURA, H., ORITA, S., TAKAI, Y. AND SANO, K.
Cloning of a brain-type isoform of human Rab GDI and its expression in
human neuroblastoma cell lines and tumor specimens. 
CANCER RES. 55 5445-5450 (1995). 
 
3. SCHALK, I., ZENG, K., WU, S.K., STURA, E.A., MATTESON, J., HUANG, M.,
TANDON, A., WILSON, I.A. AND BALCH, W.E.
Structure and mutational analysis of Rab GDP-dissociation inhibitor. 
NATURE 381 42-48 (1996).

Documentation
Rab proteins constitute a family of small GTPases that serve a regulatory
role in vesicular membrane traffic [1,2]; C-terminal geranylgeranylation is
crucial for their membrane association and function. This post-translational
modification is catalysed by Rab geranylgeranyl transferase (Rab-GGTase), a 
multi-subunit enzyme that contains a catalytic heterodimer and an accessory
component, termed Rab escort protein (REP)-1 [1]. REP-1 presents newly-
synthesised Rab proteins to the catalytic component, and forms a stable
complex with the prenylated proteins following the transfer reaction. 
 
The mechanism of REP-1-mediated membrane association of Rab5 is similar
to that mediated by Rab GDP dissociation inhibitor (GDI). REP-1 and Rab GDI 
also share other functional properties, including the ability to inhibit the
release of GDP and to remove Rab proteins from membranes. 
 
The crystal structure of the bovine alpha-isoform of Rab GDI has been
determined to a resolution of 1.81A [3]. The protein is composed of two
main structural units: a large complex multi-sheet domain I, and a smaller
alpha-helical domain II.
 
The structural organisation of domain I is closely related to FAD-containing
monooxygenases and oxidases [3]. Conserved regions common to GDI and the
choroideraemia gene product, which delivers Rab to catalytic subunits of
Rab geranylgeranyltransferase II, are clustered on one face of the domain
[2]. The two most conserved regions form a compact structure at the apex of
the molecule; site-directed mutagenesis has shown these regions to play a
critical role in the binding of Rab proteins [3].
 
RABGDIREP is a 7-element fingerprint that provides a signature for the 
Rab GDI/REP family. The fingerprint was derived from an initial alignment
of 8 sequences: the motifs were drawn from short conserved regions spanning
the N-terminal half of the alignment - motif 1 spans strand 1 and helix 1;
motif 2 includes the second strand; motif 3 spans helix 4 and strands 4 and
5; motif 4 spans helices 5 and 6, and strand 6; motif 5 encodes helix 8; 
motif 6 spans the C-terminus of helix 13, helix 14 and strand 8; and motif
7 encompasses helix 15 and strand 9. Two iterations on OWL30.2 were required
to reach convergence, at which point a true set comprising 27 sequences was
identified. Three partial matches were also found (YSCMRS6A, GDIA_MOUSE and
A41937), all of which are fragments. 
 
An update on SPTR37_9f identified a true set of 28 sequences, and 1
partial match.
Summary Information
  28 codes involving  7 elements
0 codes involving 6 elements
0 codes involving 5 elements
1 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
728282828282828
60000000
50000000
41101001
30000000
20000000
1234567
True Positives
GDI1_YEAST    GDIA_BOVIN    GDIA_HUMAN    GDIA_RAT      
GDIB_HUMAN GDIB_MOUSE GDIB_RAT O02441
O22402 O22470 O22471 O24532
O24653 O43928 O65744 O93382
Q06761 Q21449 Q24349 Q26001
Q61598 Q96254 Q96284 RAE1_HUMAN
RAE1_RAT RAE2_HUMAN RAEP_YEAST YD4C_SCHPO
True Positive Partials
Codes involving 4 elements
O60112
Sequence Titles
GDI1_YEAST  SECRETORY PATHWAY GDP DISSOCIATION INHIBITOR - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). 
GDIA_BOVIN RAB GDP DISSOCIATION INHIBITOR ALPHA (RAB GDI ALPHA) (GDI-1) (SMG P25A GDI) - BOS TAURUS (BOVINE).
GDIA_HUMAN RAB GDP DISSOCIATION INHIBITOR ALPHA (RAB GDI ALPHA) (GDI-1) (XAP-4) - HOMO SAPIENS (HUMAN).
GDIA_RAT RAB GDP DISSOCIATION INHIBITOR ALPHA (RAB GDI ALPHA) (GDI-1) - RATTUS NORVEGICUS (RAT).
GDIB_HUMAN RAB GDP DISSOCIATION INHIBITOR BETA (RAB GDI BETA) (GDI-2) - HOMO SAPIENS (HUMAN).
GDIB_MOUSE RAB GDP DISSOCIATION INHIBITOR BETA (RAB GDI BETA) (GDI-2) - MUS MUSCULUS (MOUSE).
GDIB_RAT RAB GDP DISSOCIATION INHIBITOR BETA (RAB GDI BETA) (GDI-2) - RATTUS NORVEGICUS (RAT).
O02441 GDP-DISSOCIATION INHIBITOR - GEODIA CYDONIUM (SPONGE).
O22402 GDP DISSOCIATION INHIBITOR - NICOTIANA TABACUM (COMMON TOBACCO).
O22470 GDP DISSOCIATION INHIBITOR PROTEIN OSGDI1 - ORYZA SATIVA (RICE).
O22471 GDP DISSOCIATION INHIBITOR PROTEIN OSGDI2 - ORYZA SATIVA (RICE).
O24532 GDP DISSOCIATION INHIBITOR PROTEIN GDIV1P - VOLVOX CARTERI F. NAGARIENSIS.
O24653 GDI2 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O43928 GDP DISSOCIATION INHIBITOR BETA - HOMO SAPIENS (HUMAN).
O65744 GDP DISSOCIATION INHIBITOR - CICER ARIETINUM (CHICKPEA) (GARBANZO).
O93382 RAB-GDP DISSOCIATION INHIBITOR - GALLUS GALLUS (CHICKEN).
Q06761 MRS6 PROTEIN - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q21449 RABGDI PROTEIN - CAENORHABDITIS ELEGANS.
Q24349 GDP DISSOCIATION INHIBITOR - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q26001 RABGDI PROTEIN - PLASMODIUM FALCIPARUM.
Q61598 GUANOSINE DIPHOSPHATE (GDP) DISSOCIATION INHIBITOR 3 (GDP DISSOCIATION INHIBITOR BETA) - MUS MUSCULUS (MOUSE).
Q96254 GDP DISSOCIATION INHIBITOR - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q96284 GDP-ASSOCIATED INHIBITOR - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
RAE1_HUMAN RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 1 (RAB ESCORT PROTEIN 1) (REP-1) (CHOROIDERAEMIA PROTEIN) (TCD PROTEIN) - HOMO SAPIENS (HUMAN).
RAE1_RAT RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 1 (RAB ESCORT PROTEIN 1) (REP-1) - RATTUS NORVEGICUS (RAT).
RAE2_HUMAN RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 2 (RAB ESCORT PROTEIN 2) (REP-2) (CHOROIDERAEMIA-LIKE PROTEIN) - HOMO SAPIENS (HUMAN).
RAEP_YEAST RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A (RAB ESCORT PROTEIN) (REP) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YD4C_SCHPO PUTATIVE SECRETORY PATHWAY GDP DISSOCIATION INHIBITOR - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).

O60112 GERANYLGERANYL TRANSFERASE COMPONENT - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
Scan History
OWL30_2    2  100  NSINGLE    
SPTR37_9f 2 51 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
DVIVIGTGLPESIIAAACS RAE1_HUMAN 10 10 -
DVIVIGTGLPESIIAAACS RAE1_RAT 10 10 -
DVVIIGTGLPESILAAACS RAE2_HUMAN 10 10 -
DAIVLGTGLKECIISGMLS CELRABGDI 6 6 -
DVIVLGTGLKECILSGLLS GCGDI 6 6 -
DVLIAGTGMVESVLAAALA RAEP_YEAST 48 48 -
DVIVLGTGLTECILSGIMS GDIA_BOVIN 6 6 -
DVIVLGTGLTECVLSGLLS YD4C_SCHPO 6 6 -

Motif 2 width=18
Element Seqn Id St Int Rpt
SRSGQRVLHIDSRSYYGG RAE2_HUMAN 28 -1 -
SRSGQRVLHVDSRSYYGG RAE1_RAT 28 -1 -
SRSGRRVLHVDSRSYYGG RAE1_HUMAN 28 -1 -
SVSGKKVLHIDRNNYYGG CELRABGDI 24 -1 -
SVDGKKVLHIDRNDYYGA YD4C_SCHPO 24 -1 -
SVSGKKVLHMDRNKYYGG GCGDI 24 -1 -
SVNGKKVLHMDRNPYYGG GDIA_BOVIN 24 -1 -
AWQGSNVLHIDKNDYYGD RAEP_YEAST 66 -1 -

Motif 3 width=18
Element Seqn Id St Int Rpt
RRFNIDLVSKLLYSRGLL RAE1_HUMAN 225 179 -
RDWNVDLIPKFLMANGQL GCGDI 70 28 -
RDWNVDLIPKFLMANGPL CELRABGDI 71 29 -
RDWNVDLIPKFLMANGQL GDIA_BOVIN 70 28 -
RDWCVDLVPKFLMANGDL YD4C_SCHPO 69 27 -
RRFNIDLVSQLLYSRGLL RAE1_RAT 222 176 -
RRFNIDLVSKLLYSQGLL RAE2_HUMAN 227 181 -
RDFGIDLSPKILFAKSDL RAEP_YEAST 127 43 -

Motif 4 width=17
Element Seqn Id St Int Rpt
LVKMLLYTEVTRYLDFK GDIA_BOVIN 87 -1 -
LVKLLIHTGVTRYLEFK CELRABGDI 88 -1 -
LLSILIKSRVHQYLEFQ RAEP_YEAST 144 -1 -
LIDLLIKSDVSRYVEFK RAE2_HUMAN 244 -1 -
LVKLLIHSGVTRYLEFK GCGDI 87 -1 -
LIDLLIKSNVSRYAEFK RAE1_RAT 239 -1 -
LIDLLIKSNVSRYAEFK RAE1_HUMAN 242 -1 -
LTNILIYTDVTRYIEFK YD4C_SCHPO 86 -1 -

Motif 5 width=16
Element Seqn Id St Int Rpt
EKRRFKKFLVWVQQFD CELRABGDI 137 32 -
EKRRFRKFLVFVANFD GDIA_BOVIN 136 32 -
EKRRAKKFLEWVNNYR YD4C_SCHPO 135 32 -
EKRMLMKFLTFCMEYE RAE1_HUMAN 291 32 -
EKRMLMKFLTFCVEYE RAE1_RAT 288 32 -
EKRMLMKFLTFCLEYE RAE2_HUMAN 293 32 -
TKRNLMKFIKFVLNWE RAEP_YEAST 193 32 -
EKRRFRNFVSWVGSYD GCGDI 137 33 -

Motif 6 width=18
Element Seqn Id St Int Rpt
FLQCLGRFGNTPFLFPLY RAE2_HUMAN 363 54 -
YSDSLARYGKSPYLYPLY CELRABGDI 213 60 -
YSESIQRYGKSPYLYPLY GCGDI 212 59 -
YSESLARYGKSPYLYPLY GDIA_BOVIN 212 60 -
YASSIAKFGKSPYIYPLY YD4C_SCHPO 211 60 -
FLHCLGRYGNTPFLFPLY RAE1_HUMAN 361 54 -
ALQRIRRYLTSFDVYGPF RAEP_YEAST 257 48 -
FLQCLGRYGNTPFLFPLY RAE1_RAT 358 54 -

Motif 7 width=22
Element Seqn Id St Int Rpt
GLGELPQGFARLSAIYGGTYML GDIA_BOVIN 230 0 -
GLGELPQGFARLSAIYGGTYML GCGDI 230 0 -
GPGELSQGFCRSAAVGGATYKL RAEP_YEAST 283 8 -
GQGEIPQGFCRMCAVFGGIYCL RAE2_HUMAN 381 0 -
GQGELPQCFCRMCAVFGGIYCL RAE1_RAT 376 0 -
GQGELPQCFCRMCAVFGGIYCL RAE1_HUMAN 379 0 -
GLGELPQGFARLSAIYGGTYML YD4C_SCHPO 229 0 -
GLGELPQGFARLSAIYGGTYML CELRABGDI 231 0 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
DVIVLGTGLTECILSGIMS GDIB_HUMAN 6 6 -
DVIVLGTGLTECILSGIMS O43928 6 6 -
DVIVLGTGLTECILSGIMS GDIA_BOVIN 6 6 -
DVIVLGTGLTECILSGIMS GDIA_RAT 6 6 -
DVIVLGTGLTECILSGIMS GDIA_HUMAN 6 6 -
DVIVLGTGLTECILSGIMS O93382 6 6 -
DVIVLGTGLTECILSGIMS Q61598 6 6 -
DVIVLGHWLTECILSGIMS GDIB_MOUSE 6 6 -
DVIVLGTGLTECILSGIMS GDIB_RAT 6 6 -
DAIVLGTGLKECIISGMLS Q21449 6 6 -
DVIVLGTGLKECILSGLLS O02441 6 6 -
DVDVLGTGLKECILSGIML Q24349 6 6 -
DVIVLGTGLKECILSGLLS O22402 6 6 -
EVIVLGTGLKECILSGLLS Q96254 6 6 -
EVIVLGTGLKECILSGLLS Q96284 6 6 -
DVIVLGTGLKECILSGLLS O22470 6 6 -
DVIVLGTGLKECILSGLLS O65744 6 6 -
EVIVLGTGLKECILSGLLS O24653 6 6 -
DVIVLGTGLTECVLSGLLS YD4C_SCHPO 6 6 -
DLIVLGTGLKECILSGLLS O22471 6 6 -
DVIVLGTGITECILSGLLS GDI1_YEAST 11 11 -
DVIVLGTGLKECIISGLLS O24532 6 6 -
DVIILGTGLKECILSGLLS Q26001 6 6 -
DVIVIGTGLPESIIAAACS RAE1_HUMAN 10 10 -
DVIVIGTGLPESIIAAACS RAE1_RAT 10 10 -
DVVIIGTGLPESILAAACS RAE2_HUMAN 10 10 -
DVLIAGTGMVESVLAAALA Q06761 39 39 -
DVLIAGTGMVESVLAAALA RAEP_YEAST 48 48 -

Motif 2 width=18
Element Seqn Id St Int Rpt
SVNGKKVLHMDRNPYYGG GDIB_HUMAN 24 -1 -
SVNGKKVLHMDRNPYYGG O43928 24 -1 -
SVNGKKVLHMDRNPYYGG GDIA_BOVIN 24 -1 -
SVNGKKVLHMDRNPYYGG GDIA_RAT 24 -1 -
SVNGKKVLHMDRNPYYGG GDIA_HUMAN 24 -1 -
SVNGKKVLHMDRNSYYGG O93382 24 -1 -
SVNGKKVLHMDQNPYYGG Q61598 24 -1 -
SVNGKKVLHMDRNPYYGG GDIB_MOUSE 24 -1 -
SVNGKKVLHMDQNPYYGG GDIB_RAT 24 -1 -
SVSGKKVLHIDRNNYYGG Q21449 24 -1 -
SVSGKKVLHMDRNKYYGG O02441 24 -1 -
SVSGKKVLHIDRNKYYGG Q24349 25 0 -
SVDGLKVLHMDRNDYYGG O22402 24 -1 -
SVDGLKVLHMDRNDYYGG Q96254 24 -1 -
SVDGLKVLHMDRNDYYGG Q96284 24 -1 -
SVDGLKVLHMDRNDYYGG O22470 24 -1 -
SVDGLKVLHMDRNDYYGG O65744 24 -1 -
SVDGVKVLHMDRNDYYGG O24653 24 -1 -
SVDGKKVLHIDRNDYYGA YD4C_SCHPO 24 -1 -
SVDGLKVLHMDRNDYYGG O22471 24 -1 -
SVDGKKVLHIDKQDHYGG GDI1_YEAST 29 -1 -
SVDKKKVLHVDRNNYYGG O24532 24 -1 -
SHYGKKILVLDRNPYYGG Q26001 24 -1 -
SRSGRRVLHVDSRSYYGG RAE1_HUMAN 28 -1 -
SRSGQRVLHVDSRSYYGG RAE1_RAT 28 -1 -
SRSGQRVLHIDSRSYYGG RAE2_HUMAN 28 -1 -
AWQGSNVLHIDKNDYYGD Q06761 57 -1 -
AWQGSNVLHIDKNDYYGD RAEP_YEAST 66 -1 -

Motif 3 width=18
Element Seqn Id St Int Rpt
RDWNVDLIPKFLMANGQL GDIB_HUMAN 70 28 -
RDWNVDLIPKFLMANGQL O43928 70 28 -
RDWNVDLIPKFLMANGQL GDIA_BOVIN 70 28 -
RDWNVDLIPKFLMANGQL GDIA_RAT 70 28 -
RDWNVDLIPKFLMANGQL GDIA_HUMAN 70 28 -
RDWNVDLIPPFLMANGQL O93382 70 28 -
RDWNVDLIPKFLMANGQL Q61598 70 28 -
RDWNVDLIPKFLMANGQL GDIB_MOUSE 70 28 -
RDWNVDLIPKFLMANGQL GDIB_RAT 70 28 -
RDWNVDLIPKFLMANGPL Q21449 71 29 -
RDWNVDLIPKFLMANGQL O02441 70 28 -
RDWNVDLIPKFLMANGQL Q24349 70 27 -
RDFNVDMIPKFIMANGAL O22402 69 27 -
RDYNVDMMPKFMMANGKL Q96254 69 27 -
RDYNVDMMPKFMMANGKL Q96284 69 27 -
RDYNVDMVPKFMMANGTL O22470 69 27 -
KDYNIDMNPKFIMANGML O65744 69 27 -
RDYNVDMMPKFMMGNGKL O24653 69 27 -
RDWCVDLVPKFLMANGDL YD4C_SCHPO 69 27 -
KDYNVDMVPKFMMANGTL O22471 69 27 -
RDWNVDLIPKFLMANGEL GDI1_YEAST 78 31 -
RDYNVDMVPKFMMANGKL O24532 69 27 -
RHWNVDLIPKFILVGGNL Q26001 69 27 -
RRFNIDLVSKLLYSRGLL RAE1_HUMAN 225 179 -
RRFNIDLVSQLLYSRGLL RAE1_RAT 222 176 -
RRFNIDLVSKLLYSQGLL RAE2_HUMAN 227 181 -
RDFGIDLSPKILFAKSDL Q06761 118 43 -
RDFGIDLSPKILFAKSDL RAEP_YEAST 127 43 -

Motif 4 width=17
Element Seqn Id St Int Rpt
LVKMLLYTEVTRYLDFK GDIB_HUMAN 87 -1 -
LVKMLLYTEVTRYLDFK O43928 87 -1 -
LVKMLLYTEVTRYLDFK GDIA_BOVIN 87 -1 -
LVKMLLYTEVTRYLDFK GDIA_RAT 87 -1 -
LVKMLLYTEVTRYLDFK GDIA_HUMAN 87 -1 -
LVKMLLYTEVTRYLDFK O93382 87 -1 -
LVKMLLFTEVTRYMDFK Q61598 87 -1 -
LVKMLLFTEVTRYLDFK GDIB_MOUSE 87 -1 -
LVKMLLFTEVTRYMDFK GDIB_RAT 87 -1 -
LVKLLIHTGVTRYLEFK Q21449 88 -1 -
LVKLLIHSGVTRYLEFK O02441 87 -1 -
LVKLLIHTGVTRYLEFK Q24349 87 -1 -
LVRVLIHTDVTKYLYFK O22402 86 -1 -
LVRVLIHTDVTKYLSFK Q96254 86 -1 -
LVRVLIHTDVTKYLSFK Q96284 86 -1 -
LVRTLIHTDVTKYLSFK O22470 86 -1 -
LVRVLIHTDVTKYLYFK O65744 86 -1 -
LVRTLIHTDVTKYLSFK O24653 86 -1 -
LTNILIYTDVTRYIEFK YD4C_SCHPO 86 -1 -
LVRTLIHTDVTKYLSFK O22471 86 -1 -
LTNILIHTDVTRYVDFK GDI1_YEAST 95 -1 -
LVRVLLHTDVVKYLEFK O24532 86 -1 -
LVKILKKTRVTNYLEWL Q26001 86 -1 -
LIDLLIKSNVSRYAEFK RAE1_HUMAN 242 -1 -
LIDLLIKSNVSRYAEFK RAE1_RAT 239 -1 -
LIDLLIKSDVSRYVEFK RAE2_HUMAN 244 -1 -
LLSILIKSRVHQYLEFQ Q06761 135 -1 -
LLSILIKSRVHQYLEFQ RAEP_YEAST 144 -1 -

Motif 5 width=16
Element Seqn Id St Int Rpt
EKRRFRKFLVYVANFD GDIB_HUMAN 136 32 -
EKRRFRKFLVYVANFD O43928 136 32 -
EKRRFRKFLVFVANFD GDIA_BOVIN 136 32 -
EKRRFRKFLVFVANFD GDIA_RAT 136 32 -
EKRRFRKFLVFVANFD GDIA_HUMAN 136 32 -
EKRRFRKFLVYVANFD O93382 136 32 -
EKRRFRKFLVYVANFD Q61598 136 32 -
EKRRFRKFLVYVANFD GDIB_MOUSE 136 32 -
EKRRFRKFLVYVANFD GDIB_RAT 136 32 -
EKRRFKKFLVWVQQFD Q21449 137 32 -
EKRRFRNFVSWVGSYD O02441 137 33 -
EKRRFRNFLIYVQDFR Q24349 136 32 -
EKRRARKFFIYVQDYN O22402 135 32 -
EKRRAGKFFSYVQEYD Q96254 135 32 -
EKRRAGKFFSYVQEYD Q96284 135 32 -
EKRRARNFFIYVQDYD O22470 135 32 -
EKRRARKFFIYVQDYN O65744 135 32 -
EKRRAGKFFSFVQEYD O24653 135 32 -
EKRRAKKFLEWVNNYR YD4C_SCHPO 135 32 -
EKRRARNFFIYVQDYN O22471 135 32 -
EKRRMKKFLEWISSYK GDI1_YEAST 144 32 -
EKRRARNFFLYVQDYE O24532 135 32 -
EKNRCKNFYQYVSEWD Q26001 144 41 -
EKRMLMKFLTFCMEYE RAE1_HUMAN 291 32 -
EKRMLMKFLTFCVEYE RAE1_RAT 288 32 -
EKRMLMKFLTFCLEYE RAE2_HUMAN 293 32 -
TKRNLMKFIKFVLNWE Q06761 184 32 -
TKRNLMKFIKFVLNWE RAEP_YEAST 193 32 -

Motif 6 width=18
Element Seqn Id St Int Rpt
YSESLARYGKSPYLYPLY GDIB_HUMAN 212 60 -
YSESLARYGKSPYLYPLY O43928 212 60 -
YSESLARYGKSPYLYPLY GDIA_BOVIN 212 60 -
YSESLARYGKSPYLYPLY GDIA_RAT 212 60 -
YSESLARYGKSPYLYPLY GDIA_HUMAN 212 60 -
YSESLARYGKSPYLYPLY O93382 212 60 -
YSESLARYGKSPYLYPLY Q61598 212 60 -
YSESLARYGKSPYLYPLY GDIB_MOUSE 212 60 -
YSESLARYGKSPYLYPLY GDIB_RAT 212 60 -
YSDSLARYGKSPYLYPLY Q21449 213 60 -
YSESIQRYGKSPYLYPLY O02441 212 59 -
YSDSLARYGKSPYLYPMY Q24349 212 60 -
AESLARFQGGSPYIYPLY O22402 212 61 -
AESLARFQGGSPYIYPLY Q96254 212 61 -
AESLARFQGGSPYIYPLY Q96284 212 61 -
AESLPRFQGGSPSIYPLY O22470 212 61 -
AESLARFQGGSPYIYPLY O65744 212 61 -
AESLARFQGTSPYIYPLY O24653 212 61 -
YASSIAKFGKSPYIYPLY YD4C_SCHPO 211 60 -
AESLAPFQGGSPSIYPLY O22471 212 61 -
YCQSVARYGKSPYLYPMY GDI1_YEAST 220 60 -
ESLFRYEGLKSPYLYPRY O24532 213 62 -
YMQSISAFGKSPFIYPLY Q26001 220 60 -
FLHCLGRYGNTPFLFPLY RAE1_HUMAN 361 54 -
FLQCLGRYGNTPFLFPLY RAE1_RAT 358 54 -
FLQCLGRFGNTPFLFPLY RAE2_HUMAN 363 54 -
ALQRIRRYLTSFDVYGPF Q06761 248 48 -
ALQRIRRYLTSFDVYGPF RAEP_YEAST 257 48 -

Motif 7 width=22
Element Seqn Id St Int Rpt
GLGELPQGFARLSAIYGGTYML GDIB_HUMAN 230 0 -
GLGELPQGFARLSAIYGGTYML O43928 230 0 -
GLGELPQGFARLSAIYGGTYML GDIA_BOVIN 230 0 -
GLGELPQGFARLSAIYGGTYML GDIA_RAT 230 0 -
GLGELPQGFARLSAIYGGTYML GDIA_HUMAN 230 0 -
GLGELPQGFARLSAIYGGTYML O93382 230 0 -
GLGELPQGFARLSAIYGGTYML Q61598 230 0 -
GLGELPQGFARLSAIYGGTYML GDIB_MOUSE 230 0 -
GPWELPQGFARLSAIYGGTYML GDIB_RAT 230 0 -
GLGELPQGFARLSAIYGGTYML Q21449 231 0 -
GLGELPQGFARLSAIYGGTYML O02441 230 0 -
GLGELPQGFARLSAIYGGTYML Q24349 230 0 -
GLGELPQAFARLSAVYGGTYML O22402 230 0 -
GLGELPQAFARLSAVYGGTYML Q96254 230 0 -
GLGELPQAFARLSAVYGGTYML Q96284 230 0 -
GLGELPQGFARLRAVYGGTYML O22470 230 0 -
GLGELPQAFARLSAVYGGTYML O65744 230 0 -
GLGELPQAFARLSAVYGGTYML O24653 230 0 -
GLGELPQGFARLSAIYGGTYML YD4C_SCHPO 229 0 -
GLGELPQGHARLSAVYGGTYIL O22471 230 0 -
GLGELPQGFARLSAIYGGTYML GDI1_YEAST 238 0 -
GLGELPQAFARLSAVYGGTYML O24532 231 0 -
GLGGIPEGFSRMCAINGGTFML Q26001 238 0 -
GQGELPQCFCRMCAVFGGIYCL RAE1_HUMAN 379 0 -
GQGELPQCFCRMCAVFGGIYCL RAE1_RAT 376 0 -
GQGEIPQGFCRMCAVFGGIYCL RAE2_HUMAN 381 0 -
GPGELSQGFCRSAAVGGPTYKL Q06761 274 8 -
GPGELSQGFCRSAAVGGATYKL RAEP_YEAST 283 8 -