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PR00704

Identifier
CALPAIN  [View Relations]  [View Alignment]  
Accession
PR00704
No. of Motifs
9
Creation Date
08-MAR-1997  (UPDATE 10-JUN-1999)
Title
Calpain cysteine protease (C2) family signature
Database References

PROSITE; PS00139 THIOL_PROTEASE_CYS; PS00639 THIOL_PROTEASE_HIS; PS00640 THIOL_PROTEASE_ASN

BLOCKS; BL00139
PFAM; PF00648 Cys_protease_2
INTERPRO; IPR001300
Literature References
1. RAWLINGS, N.D. AND BARRETT, A.J.
Families of cysteine peptidases.
METHODS ENZYMOL. 244 461-486 (1994).
 
2. HATA, A., OHNO, S., AKITA, Y. AND SUZUKI, K.
Tandemly reiterated negative enhancer-like elements regulate transcription
of a human gene for the large subunit of calcium-dependent protease.
J.BIOL.CHEM. 264(11) 6404-6411 (1989).
 
3. SORIMACHI, H., IMAJOH-OHMI, S., EMORI, Y., KAWASAKI, H., OHNO, S., 
MINAMI, Y. AND SUZUKI, K.
Molecular cloning of a novel mammalian calcium-dependent protease distinct
from both m- and mu-types. Specific expression of the mRNA in skeletal
muscle.
J.BIOL.CHEM. 264(33) 20106-20111 (1989).

Documentation
Cysteine protease activity is dependent on an active dyad of cysteine and
histidine, the order and spacing of these residues varying in the 20 or so
known families. Families C1, C2 and C10 are loosely termed papain-like, and 
nearly half of all cysteine proteases are found exclusively in viruses [1].
 
Calpain is an intracellular protease involved in many important cellular
functions that are regulated by calcium [2]. The protein is a complex of 2
polypeptide chains (light and heavy), with three known forms in mammals 
[1,3]: a highly calcium-sensitive (i.e., micro-molar range) form known as
mu-calpain, mu-CANP or calpain I; a form sensitive to calcium in the
milli-molar range, known as m-calpain, m-CANP or calpain II; and a third
form, known as p94, which is found in skeletal muscle only [3]. 
 
All three forms have identical light but different heavy chains [1,2].
The heavy chain comprises four domains: domain 2 contains the catalytic
region; domain 4 binds calcium and regulates activity [1]. Domain 2 shows
low levels of sequence similarity to papain; although the catalytic His has
not been located by biochemical means, it is likely that calpain and papain
are related [1]. Domain 4 has four EF hand calcium-binding regions and is
simmilar to sorcin and the Ca2+-binding region of calpain light chain [1]. 
 
Calpain shows preferential cleavage for Tyr-|-XAA, Met-|-XAA and Arg-|-XAA
with leucine or valine as the P2 residue. The product of the Drosophila
gene sol has also been shown to be similar to calpain [1].
 
CALPAIN is a 9-element fingerprint that provides a signature for the 
heavy chain of the calpain cysteine protease (C2) family. The fingerprint
was derived from an initial alignment of 11 sequences: the motifs were
drawn from conserved regions spanning virtually the full alignment length -
motifs 2 and 3 span the region encoded by PROSITE pattern THIOL_PROTEASE_CYS
(PS00139), which contains the catalytic Cys. Two iterations on OWL30.0 were
required to reach convergence, at which point a true set comprising 33 
sequences was identified. Several partial matches were also found: S57195,
CAN3_PIG, CAN2_RABIT, SSU23954 and CAN1_PIG are calpain fragments that lack
portions of sequence bearing one or more motifs; SOL_DROME is a Drosophila
optic lobe protein that matches motifs 1, 3, 4, 6 and 7.
 
An update on SPTR37_9f identified a true set of 30 sequences, and 11
partial matches.
Summary Information
  30 codes involving  9 elements
0 codes involving 8 elements
0 codes involving 7 elements
1 codes involving 6 elements
2 codes involving 5 elements
1 codes involving 4 elements
3 codes involving 3 elements
4 codes involving 2 elements
Composite Feature Index
9303030303030303030
8000000000
7000000000
6101111100
5202202200
4000110101
3002121201
2002103200
123456789
True Positives
CAN1_HUMAN    CAN2_CHICK    CAN2_HUMAN    CAN2_MOUSE    
CAN2_RAT CAN3_CHICK CAN3_HUMAN CAN3_MOUSE
CAN3_RAT CANX_CHICK CAN_DROME CAN_SCHMA
O08688 O08702 O14815 O15484
O35350 O35646 O42133 O46596
O54843 O70376 O70482 O88501
O88666 O88977 P97571 Q22036
Q64698 YKR2_CAEEL
True Positive Partials
Codes involving 6 elements
O75808
Codes involving 5 elements
O61346 SOL_DROME
Codes involving 4 elements
Q22143
Codes involving 3 elements
O02259 O44903 Q00204
Codes involving 2 elements
O02260 O18165 P91312 Q22386
Sequence Titles
CAN1_HUMAN  CALPAIN 1, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (MU-TYPE) - HOMO SAPIENS (HUMAN). 
CAN2_CHICK CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (M-TYPE) (MILLIMOLAR-CALPAIN) - GALLUS GALLUS (CHICKEN).
CAN2_HUMAN CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (M-TYPE) - HOMO SAPIENS (HUMAN).
CAN2_MOUSE CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (M-TYPE) (MILLIMOLAR-CALPAIN) - MUS MUSCULUS (MOUSE).
CAN2_RAT CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (M-TYPE) - RATTUS NORVEGICUS (RAT).
CAN3_CHICK CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM- ACTIVATED NEUTRAL PROTEINASE) (CANP) (P94 PROTEIN) (MUSCLE-SPECIFIC CALCIUM-ACTIVATED NEUTRAL PROTEASE 3 LARGE SUBUNIT) - GALLUS GALLUS (CHICKEN).
CAN3_HUMAN CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM- ACTIVATED NEUTRAL PROTEINASE) (CANP) (P94 PROTEIN) (MUSCLE-SPECIFIC CALCIUM-ACTIVATED NEUTRAL PROTEASE 3 LARGE SUBUNIT) - HOMO SAPIENS (HUMAN).
CAN3_MOUSE CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM- ACTIVATED NEUTRAL PROTEINASE) (CANP) (P94 PROTEIN) (MUSCLE-SPECIFIC CALCIUM-ACTIVATED NEUTRAL PROTEASE 3 LARGE SUBUNIT) - MUS MUSCULUS (MOUSE).
CAN3_RAT CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM- ACTIVATED NEUTRAL PROTEINASE) (CANP) (P94 PROTEIN) (MUSCLE-SPECIFIC CALCIUM-ACTIVATED NEUTRAL PROTEASE 3 LARGE SUBUNIT) - RATTUS NORVEGICUS (RAT).
CANX_CHICK CALPAIN, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM- ACTIVATED NEUTRAL PROTEINASE) (CANP) (MU/M-TYPE) - GALLUS GALLUS (CHICKEN).
CAN_DROME CALPAIN (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) - DROSOPHILA MELANOGASTER (FRUIT FLY).
CAN_SCHMA CALPAIN (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) - SCHISTOSOMA MANSONI (BLOOD FLUKE).
O08688 CALPAIN 5 (CALPAIN-LIKE PROTEASE) - MUS MUSCULUS (MOUSE).
O08702 CALPAIN LP82 - RATTUS NORVEGICUS (RAT).
O14815 DIGESTIVE TRACT-SPECIFIC CALPAIN (EC 3.4.22.17) - HOMO SAPIENS (HUMAN).
O15484 CALPAIN-LIKE PROTEASE - HOMO SAPIENS (HUMAN).
O35350 CALPAIN 1 (MICROMOLAR CALCIUM ACTIVATED NEUTRAL PROTEASE LARGE SUBUNIT) - MUS MUSCULUS (MOUSE).
O35646 CALPAIN 6 (CALPAIN-LIKE PROTEASE) - MUS MUSCULUS (MOUSE).
O42133 MUCL (EC 3.4.22.17) - GALLUS GALLUS (CHICKEN).
O46596 SKELETAL MUSCLE SPECIFIC CALPAIN - SUS SCROFA (PIG).
O54843 CALPAIN 2 (80KDA M-CALPAIN SUBUNIT) - MUS MUSCULUS (MOUSE).
O70376 CALPAIN ISOFORM LP85 - RATTUS NORVEGICUS (RAT).
O70482 MUSCLE TYPE CALPAIN P94 - RATTUS NORVEGICUS (RAT).
O88501 CALPAIN-LIKE PROTEASE - RATTUS NORVEGICUS (RAT).
O88666 CALPAIN I LARGE SUBUNIT - MUS MUSCULUS (MOUSE).
O88977 CALPAIN LP82 - MUS MUSCULUS (MOUSE).
P97571 MU-CALPAIN LARGE SUBUNIT (EC 3.4.22.17) - RATTUS NORVEGICUS (RAT).
Q22036 TRA-3 - CAENORHABDITIS ELEGANS.
Q64698 CALPAIN, LARGE (CATALYTIC) SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE) (CANP) (STOMACH-SPECIFIC CALCIUM-ACTIVATED NEUTRAL PROTEASE LARGE SUBUNIT) (NCL2) - RATTUS NORVEGICUS (RAT).
YKR2_CAEEL HYPOTHETICAL 70.9 KD PROTEIN C06G4.2 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.

O75808 SMALL OPTIC LOBES HOMOLOG - HOMO SAPIENS (HUMAN).

O61346 SMALL OPTIC LOBES - DROSOPHILA MELANOGASTER (FRUIT FLY).
SOL_DROME SMALL OPTIC LOBES PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).

Q22143 T04A8.16 PROTEIN - CAENORHABDITIS ELEGANS.

O02259 F44F1.1 PROTEIN - CAENORHABDITIS ELEGANS.
O44903 W05G11.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q00204 PUTATIVE CYSTEINE PROTEASE PALB - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).

O02260 F44F1.3 PROTEIN - CAENORHABDITIS ELEGANS.
O18165 W04A4.4 PROTEIN - CAENORHABDITIS ELEGANS.
P91312 SIMILAR TO CALCIUM-ACTIVATED NEUTRAL PROTEINASES - CAENORHABDITIS ELEGANS.
Q22386 T11A5.6 PROTEIN - CAENORHABDITIS ELEGANS.
Scan History
OWL30_0    2  40   NSINGLE    
SPTR37_9f 2 77 NSINGLE
Initial Motifs
Motif 1  width=24
Element Seqn Id St Int Rpt
KTYEELHKKCLEENILYEDPDFPP CAN3_CHICK 53 53 -
QDYEQLRVRCLQSGTLFRDEAFPP CAN1_HUMAN 40 40 -
QDYEALRNECLEAGTLFQDPSFPA CAN2_HUMAN 30 30 -
KTFEQLHKKCLEKKVLYLDPEFPP CAN3_RAT 59 59 -
QNYSALRRDCRRRKVLFEDPLFPA HSNCL3PRT 11 11 -
QKYQELKQECMKDGRLFCDPTFLP MMCALPAIN 11 11 -
QKYQELKQECIKDSRLFCDPTFLP AF029232 11 11 -
QKYQELKQECIKDSRLFCDPTFLP HSCANPX 11 11 -
KQYETLVKRLKTERTLWEDPDFPA CAN_SCHMA 84 84 -
QDFYELRDQCLESKRLFEDPQFLA YKR2_CAEEL 205 205 -
QDYETILNSCLASGSLFEDPLFPA CAN_DROME 73 73 -

Motif 2 width=23
Element Seqn Id St Int Rpt
WKRPTEICADPQFIIGGATRTDI CAN2_HUMAN 75 21 -
WKRPHEINPNAKFFAGGASRFDI CAN_SCHMA 124 16 -
WLRPGEITREPQLITEGHSRFDV YKR2_CAEEL 245 16 -
WLRPHEIAENPQFFVEGYSRFDV CAN_DROME 113 16 -
RKRPKGICEDPRLFVDGISSHDL HSNCL3PRT 51 16 -
WKRPQDISDDPHLIVGNISNHQL MMCALPAIN 51 16 -
WKRPQDICDDPHLIVGNISNHQL AF029232 51 16 -
WKRPQDICDDPHLIVGNISNHQL HSCANPX 51 16 -
WKRPPEICENPRFIIGGANRTDI CAN3_RAT 99 16 -
WKRPREICENPRFIIGGANRTDI CAN3_CHICK 93 16 -
WKRPTELLSNPQFIVDGATRTDI CAN1_HUMAN 85 21 -

Motif 3 width=17
Element Seqn Id St Int Rpt
QGRLGHKPMVSAFSCLA AF029232 75 1 -
QGALGDCWLLAVVASIS CAN_SCHMA 148 1 -
QGELGDCWLLAAAANLT YKR2_CAEEL 269 1 -
QGELGDCWLLAATANLT CAN_DROME 137 1 -
QGELGDCWFLAAIACLT CAN3_CHICK 117 1 -
QGALGDCWLLAAIASLT CAN1_HUMAN 109 1 -
QGALGDCWLLAAIASLT CAN2_HUMAN 99 1 -
QGDLGDCWLLAAIACLT CAN3_RAT 123 1 -
QGQVGNCWFVAACSSLA HSNCL3PRT 75 1 -
QGRLGNKAMISAFSCLA MMCALPAIN 75 1 -
QGRLGHKPMVSAFSCLA HSCANPX 75 1 -

Motif 4 width=26
Element Seqn Id St Int Rpt
YAGIFHFHFWRFGEWVDVVIDDRLPT HSNCL3PRT 117 25 -
YAGIFHFRFWHFGEWTEVVIDDLLPT MMCALPAIN 117 25 -
YAGIFHFRFWHFGEWTEVVIDDLLPT AF029232 117 25 -
YAGIFHFRFWHFGEWTEVVIDDLLPT HSCANPX 117 25 -
YAGIFHFQFWRYGDWVDVVIDDCLPT CAN3_RAT 159 19 -
YAGIFHFQFWQYGEWVEVVVDDRLPT CAN2_HUMAN 135 19 -
YAGIFHFQLWQFGEWVDVVVDDLLPI CAN1_HUMAN 145 19 -
YAGIFHFQFWRYGDWVDVIIDDCLPT CAN3_CHICK 153 19 -
YAGIFHFRFWQYGKWVDVIIDDRLPT CAN_DROME 173 19 -
YAGIFHFQFWQYGKWVDVVIDDRLPT YKR2_CAEEL 305 19 -
YVGVVRFRFWRFGHWVEVLIDDRLPV CAN_SCHMA 185 20 -

Motif 5 width=24
Element Seqn Id St Int Rpt
LVFSFSTSMNEFWNALLEKAYAKL MMCALPAIN 147 4 -
LIYCHSNSRNEFWCALVEKAYAKL HSNCL3PRT 147 4 -
LLFVHSAEGSEFWSALLEKAYAKI CAN2_HUMAN 165 4 -
LVFTKSNHRNEFWSALLEKAYAKL CAN3_RAT 189 4 -
LVFTKSSQRNEFWSALLEKAYAKL CAN3_CHICK 183 4 -
LVFMHSNDPTEFWSALLEKAYAKL CAN_SCHMA 217 6 -
LVFVHSAEGNEFWSALLEKAYAKV CAN1_HUMAN 175 4 -
LLYMHSASNNEFWSALLEKAYAKL YKR2_CAEEL 335 4 -
LMYMHSTEKNEFWSALLEKAYAKL CAN_DROME 203 4 -
LVFSFSTSMNEFWNALLEKAYAKL HSCANPX 147 4 -
LVFSFSTSMNEFWNALLEKAYAKL AF029232 147 4 -

Motif 6 width=28
Element Seqn Id St Int Rpt
GCYEALDGLTITDIIVDFTGTLAETVDM AF029232 172 1 -
GCYEALDGLTITDIIVDFTGTLAETVDM HSCANPX 172 1 -
GCYEALDGLTITDIIMDFTGTLAEIIDM MMCALPAIN 172 1 -
GCYQALDGGNTADALVDFTGGVSEPIDL HSNCL3PRT 172 1 -
GSYEALKGGNTTEAMEDFTGGVTEFFEI CAN3_RAT 214 1 -
GCYEALSGGATTEGFEDFTGGIAEWYEL CAN2_HUMAN 190 1 -
GSYEALSGGSTSEGFEDFTGGVTEWYEL CAN1_HUMAN 200 1 -
GSYEALKGGNTTEAMEDFTGGVIEFYEI CAN3_CHICK 208 1 -
GSYEALKGGSTCEAMEDFTGGVSEWYDL CAN_DROME 228 1 -
GSYEALKGGTTSEALEDMTGGLTEFIDL YKR2_CAEEL 360 1 -
GCYAHLSGGSQSEAMEDLTGGICLSLEL CAN_SCHMA 242 1 -

Motif 7 width=22
Element Seqn Id St Int Rpt
DDGEFWMSLEDFCRNFHKLNVC AF029232 319 119 -
EDGEFWMSYDDFVYHFTKLEIC CAN3_RAT 393 151 -
EDGEFWMSFSDFLRHYSRLEIC CAN2_HUMAN 320 102 -
EDGEFWMSFRDFMREFTRLEIC CAN1_HUMAN 330 102 -
DDGEFWMSLEDFCRNFHKLNVC HSCANPX 319 119 -
ADGEFWMSYEDFVTCFSRVEVC CAN_SCHMA 373 103 -
HDGEFWMSFDDFMRNFEKMEIC YKR2_CAEEL 491 103 -
RDGEFWMSFQDFLNHFDRVEIC CAN_DROME 363 107 -
EDGEFWISLEDFMRHFTKLEIC CAN3_CHICK 386 150 -
DDGEFWMTFEDVCRYFTDIIKC HSNCL3PRT 319 119 -
DDGEFWMSLEDFCHNFHKLNVC MMCALPAIN 319 119 -

Motif 8 width=18
Element Seqn Id St Int Rpt
RGGGCINHKDTFFQNPQY HSNCL3PRT 373 32 -
RSGGCYNNRDTFLQNPQY HSCANPX 370 29 -
RSGGCYNNRDTFLQNPQY AF029232 370 29 -
RSGGCYNNRDTFLQNPQY MMCALPAIN 370 29 -
SAGGCRNFPDTFWTNPQY CAN3_RAT 443 28 -
TAGGCRNYPNTFWMNPQY CAN2_HUMAN 370 28 -
TAGGCRNYPATFWVNPQF CAN1_HUMAN 380 28 -
SAGGCRNYPDTFWTNPQY CAN3_CHICK 436 28 -
TAGGCRNFLDTFWHNPQY CAN_DROME 417 32 -
TAGGCRNYINTFANNPQF YKR2_CAEEL 549 36 -
NAGGCINNRTTYWTSPQF CAN_SCHMA 427 32 -

Motif 9 width=29
Element Seqn Id St Int Rpt
RVPPGNYVVVPSTFEPNEEAEFMLRVYTN YKR2_CAEEL 619 52 -
RVPPGSYVVIPSTFDPNIEVNFILRVFSQ CAN_SCHMA 524 79 -
KLPPGEYILVPSTFEPNKDGDFCIRVFSE CAN2_HUMAN 476 88 -
RLPPSEYVIVPSTYEPHQEGEFILRVFSE CAN3_RAT 548 87 -
DQPEGRYVIIPTTFEPGHTGEFLLRVFTD HSNCL3PRT 462 71 -
YLKKGSYVLVPTMFQHGRTSEFLLRIFSE MMCALPAIN 461 73 -
YLKKGNYVLVPTMFQHGRTSEFLLRIFSE AF029232 461 73 -
YLKKGNYVLVPTMFQHGRTSEFLLRIFSE HSCANPX 461 73 -
RLPPGEYVVVPSTFEPNKEGDFVLRFFSE CAN1_HUMAN 488 90 -
RLPPSEYVIIPSTYEPHQEGEFILRVFSE CAN3_CHICK 541 87 -
KLPPGHYLIVPSTFDPNEEGEFIIRVFSE CAN_DROME 519 84 -
Final Motifs
Motif 1  width=24
Element Seqn Id St Int Rpt
QDFVVLKQRCLAQKCLFEDRVFPA O08702 35 35 -
QDFVVLKQRCLAQKCLFEDRVFPA O70376 35 35 -
QDFVVLKQRCLAQKCLFEDRVFPA O70482 35 35 -
KTFEQLRKKCLEKKVLYLDPEFPP CAN3_MOUSE 59 59 -
KTFEQLHKKCLEKKVLYLDPEFPP CAN3_RAT 59 59 -
QDYETLRNECLEAGALFQDPSFPA O54843 30 30 -
KTFEQLHKKCLEKKVLYLDPEFPP O46596 58 58 -
QDYETLRNECLEAGALFQDPSFPA CAN2_RAT 30 30 -
QDFVVLKQRCLAQKCLFEDRVFPA O88977 35 35 -
QDYETLRARCLQSGVLFQDEAFPP O35350 40 40 -
KTFEQLHKKCLEKKVLYVDPEFPP CAN3_HUMAN 59 59 -
QDYEALRNECLEAGTLFQDPSFPA CAN2_HUMAN 30 30 -
QDYETLRNECLEAGALFQDPSFPA CAN2_MOUSE 30 30 -
QDYETLRARCLQSGVLFQDEAFPP O88666 40 40 -
QDYENLRARCLQNGVLFQDDAFPP P97571 40 40 -
QDYEQLRVRCLQSGTLFRDEAFPP CAN1_HUMAN 40 40 -
KTYEELHKKCLEENILYEDPDFPP CAN3_CHICK 53 53 -
QDFGALRRECLQGGRLFHDPSFPA CAN2_CHICK 30 30 -
QDYAALRDDCLRSGSLFRDETFPP O42133 40 40 -
QDFETLRKQCLNSGVLFKDPEFPA Q64698 30 30 -
QDYEALKQECIESGTLFRDPQFPA CANX_CHICK 32 32 -
QSFEQMRQECLQRGTLFEDADFPA O14815 27 27 -
QDYETILNSCLASGSLFEDPLFPA CAN_DROME 73 73 -
QDFYELRDQCLESKRLFEDPQFLA YKR2_CAEEL 205 205 -
QNYSALKRACLRKKVLFEDPLFPA O08688 11 11 -
KQYETLVKRLKTERTLWEDPDFPA CAN_SCHMA 84 84 -
QNYSALRQDCRRRKVLFEDPLFPA O15484 11 11 -
QKYQELKQECMKDGRLFCDPTFLP O35646 11 11 -
QNYEKLRKICIKKKQPFVDTLFPP Q22036 13 13 -
QKYQELKQDCMKDGRLFCDPTFLP O88501 11 11 -

Motif 2 width=23
Element Seqn Id St Int Rpt
WKRPKEICENPRFIIGGANRTDI O08702 79 20 -
WKRPKEICENPRFIIGGANRTDI O70376 79 20 -
WKRPKEICENPRFIIGGANRTDI O70482 79 20 -
WKRPPEICENPRFIIGGANRTDI CAN3_MOUSE 99 16 -
WKRPPEICENPRFIIGGANRTDI CAN3_RAT 99 16 -
WKRPTEICADPQFIIGGATRTDI O54843 75 21 -
WKRPPEICENPRFIIGGANRTDI O46596 98 16 -
WKRPTEICADPQFIIGGATRTDI CAN2_RAT 75 21 -
WKKPKEICENPGFIIGGANRTDI O88977 79 20 -
WKRPTELMSNPQFIVDGATRTDI O35350 85 21 -
WKRPPEICENPRFIIDGANRTDI CAN3_HUMAN 99 16 -
WKRPTEICADPQFIIGGATRTDI CAN2_HUMAN 75 21 -
WKRPTEICADPQFIIGGATRTDI CAN2_MOUSE 75 21 -
WKRPTELMSNPQFIVDGATRTDI O88666 85 21 -
WKRPTELLSNPQFIVDGATRTDI P97571 85 21 -
WKRPTELLSNPQFIVDGATRTDI CAN1_HUMAN 85 21 -
WKRPREICENPRFIIGGANRTDI CAN3_CHICK 93 16 -
WCRPTELCSCPRFIAGGATRTDI CAN2_CHICK 75 21 -
WKRPTELCRHPQFIVDGATRTDI O42133 85 21 -
WKRPTELCPNPQFIVGGATRTDI Q64698 75 21 -
WKRPSELVDDPQFIVGGATRTDI CANX_CHICK 77 21 -
WKRPGEIVKNPEFILGGATRTDI O14815 67 16 -
WLRPHEIAENPQFFVEGYSRFDV CAN_DROME 113 16 -
WLRPGEITREPQLITEGHSRFDV YKR2_CAEEL 245 16 -
WKRPKDICDDPRLFVDGISSHDL O08688 51 16 -
WKRPHEINPNAKFFAGGASRFDI CAN_SCHMA 124 16 -
WKRPKGICEDPRLFVDGISSHDL O15484 51 16 -
WKRPQDISDDPHLIVGNISNHQL O35646 51 16 -
WKRPGELHPDPHLFVEGASPNDV Q22036 53 16 -
WKRPQDISDDPHLIVGNISNHQL O88501 51 16 -

Motif 3 width=17
Element Seqn Id St Int Rpt
QGDLGDCWFLAAIACLT O08702 103 1 -
QGDLGDCWFLAAIACLT O70376 103 1 -
QGDLGDCWFLAAIACLT O70482 103 1 -
QGDLGDCWFLAAIACLT CAN3_MOUSE 123 1 -
QGDLGDCWLLAAIACLT CAN3_RAT 123 1 -
QGALGDCWLLAAIASLT O54843 99 1 -
QGDLGDCWFLAAIACLT O46596 122 1 -
QGALGDCWLLAAIASLT CAN2_RAT 99 1 -
QGDLGDCWFLAAIACLT O88977 103 1 -
QGALGDCWLLAAIASLT O35350 109 1 -
QGELGDCWFLAAIACLT CAN3_HUMAN 123 1 -
QGALGDCWLLAAIASLT CAN2_HUMAN 99 1 -
QGALGDCWLLAAIASLT CAN2_MOUSE 99 1 -
QGALGDCWLLAAIASLT O88666 109 1 -
QGALGDCWLLAAIASLT P97571 109 1 -
QGALGDCWLLAAIASLT CAN1_HUMAN 109 1 -
QGELGDCWFLAAIACLT CAN3_CHICK 117 1 -
QGALGDCWLLAAIASLT CAN2_CHICK 99 1 -
QGALGDCWLLAAIASLT O42133 109 1 -
QGGLGDCWLLAAIASLT Q64698 99 1 -
QGALGDCWLLAAIGSLT CANX_CHICK 101 1 -
QGELGDCWLLAAIASLT O14815 91 1 -
QGELGDCWLLAATANLT CAN_DROME 137 1 -
QGELGDCWLLAAAANLT YKR2_CAEEL 269 1 -
QGQVGNCWFVAACSSLA O08688 75 1 -
QGALGDCWLLAVVASIS CAN_SCHMA 148 1 -
QGQVGNCWFVAACSSLA O15484 75 1 -
QGRLGNKAMISAFSCLA O35646 75 1 -
QGILGNCWFVSACSALT Q22036 77 1 -
QGRLGNKAMISAFSCLA O88501 75 1 -

Motif 4 width=26
Element Seqn Id St Int Rpt
YAGIFHFQFWRYGDWVDVVIDDCLPT O08702 139 19 -
YAGIFHFQFWRYGDWVDVVIDDCLPT O70376 139 19 -
YAGIFHFQFWRYGDWVDVVIDDCLPT O70482 139 19 -
YAGIFHFQFWRYGDWVDVVIDDCLPT CAN3_MOUSE 159 19 -
YAGIFHFQFWRYGDWVDVVIDDCLPT CAN3_RAT 159 19 -
YAGIFHFQFWQYGEWVEVVVDDRLPT O54843 135 19 -
YAGIFHFQFWRYGDWVDVVIDDCLPT O46596 158 19 -
YAGIFHFQFWQYGEWVEVVVDDRLPT CAN2_RAT 135 19 -
YAGIFHFQFWRYGDWVDVVIDDCLPT O88977 139 19 -
YAGIFHFQLWQFGEWVDVVIDDLLPT O35350 145 19 -
YAGIFHFQFWRYGEWVDVVIDDCLPT CAN3_HUMAN 159 19 -
YAGIFHFQFWQYGEWVEVVVDDRLPT CAN2_HUMAN 135 19 -
YAGIFHFQFWQYGEWVEVVVDDRLPT CAN2_MOUSE 135 19 -
YAGIFHFQLWQFGEWVDVVIDDLLPT O88666 145 19 -
YAGIFHFQLWQFGEWVDVVVDDLLPT P97571 145 19 -
YAGIFHFQLWQFGEWVDVVVDDLLPI CAN1_HUMAN 145 19 -
YAGIFHFQFWRYGDWVDVIIDDCLPT CAN3_CHICK 153 19 -
YAGIFHFQFWQYGEWVDVVVDDRLPT CAN2_CHICK 135 19 -
YAGIFHFQIWQFGEWQDVVVDDYLPT O42133 145 19 -
YAGIFHFQFWQYGEWVEVVIDDRLPT Q64698 135 19 -
YAGIFHFQIWQFGEWVDVVVDDLLPT CANX_CHICK 137 19 -
YAGIFHFQFWQHSEWLDVVIDDRLPT O14815 127 19 -
YAGIFHFRFWQYGKWVDVIIDDRLPT CAN_DROME 173 19 -
YAGIFHFQFWQYGKWVDVVIDDRLPT YKR2_CAEEL 305 19 -
YAGIFHFNFWRFGEWVDVIVDDRLPT O08688 117 25 -
YVGVVRFRFWRFGHWVEVLIDDRLPV CAN_SCHMA 185 20 -
YAGIFHFHFWRLGMVDVVIDERLPTV O15484 117 25 -
YAGIFHFRFWHFGEWTEVVIDDLLPT O35646 117 25 -
YAGIFRFRFWRFGKWVEVVIDDLLPT Q22036 117 23 -
YAGIFRFRFWHFGEWTEVVIDDLLPT O88501 117 25 -

Motif 5 width=24
Element Seqn Id St Int Rpt
LVFTKSNHRNEFWSALLEKAYAKL O08702 169 4 -
LVFTKSNHRNEFWSALLEKAYAKL O70376 169 4 -
LVFTKSNHRNEFWSALLEKAYAKL O70482 169 4 -
LVFTKSNHRNEFWSALLEKAYAKL CAN3_MOUSE 189 4 -
LVFTKSNHRNEFWSALLEKAYAKL CAN3_RAT 189 4 -
LLFVHSAEGSEFWSALLEKAYAKI O54843 165 4 -
LVFTKSNHRNEFWSALLEKAYAKL O46596 188 4 -
LLFVHSAEGSEFWSALLEKAYAKI CAN2_RAT 165 4 -
LVFTKSNHRNEFWSALLEKAYAKL O88977 169 4 -
LVFVHSAQGNEFWSALLEKAYAKV O35350 175 4 -
LVFTKSNHRNEFWSALLEKAYAKL CAN3_HUMAN 189 4 -
LLFVHSAEGSEFWSALLEKAYAKI CAN2_HUMAN 165 4 -
LLFVHSAEGSEFWSALLEKAYAKI CAN2_MOUSE 165 4 -
LVFVHSAQGNEFWSALLEKAYAKV O88666 175 4 -
LVFVHSAQGNEFWSALLEKAYAKV P97571 175 4 -
LVFVHSAEGNEFWSALLEKAYAKV CAN1_HUMAN 175 4 -
LVFTKSSQRNEFWSALLEKAYAKL CAN3_CHICK 183 4 -
LLFVHSAEGSEFWSALLEKAYAKL CAN2_CHICK 165 4 -
LLFVHSAEGTEFWSALLEKAYAKV O42133 175 4 -
LLFLHSEEGNEFWSALLEKAYAKL Q64698 165 4 -
LLFVHSAECTEFWSALLEKAYAKL CANX_CHICK 167 4 -
LVFLHSADHNEFWSALLEKAYAKL O14815 157 4 -
LMYMHSTEKNEFWSALLEKAYAKL CAN_DROME 203 4 -
LLYMHSASNNEFWSALLEKAYAKL YKR2_CAEEL 335 4 -
LIYCHSNSKNEFWCALVEKAYAKL O08688 147 4 -
LVFMHSNDPTEFWSALLEKAYAKL CAN_SCHMA 217 6 -
LIYCHSNSRNEFWCALVEKAYAKL O15484 146 3 -
LVFSFSTSMNEFWNALLEKAYAKL O35646 147 4 -
LLFARSKTPNEFWSALLEKAFAKL Q22036 147 4 -
LVFSFSTSMNEFWNALLEKAYAKL O88501 147 4 -

Motif 6 width=28
Element Seqn Id St Int Rpt
GSYEALKGGNTTEAMEDFTGGVTEFFEI O08702 194 1 -
GSYEALKGGNTTEAMEDFTGGVTEFFEI O70376 194 1 -
GSYEALKGGNTTEAMEDFTGGVTEFFEI O70482 194 1 -
GSYEALKGGNTTEAMEDFTGGVTEFFEI CAN3_MOUSE 214 1 -
GSYEALKGGNTTEAMEDFTGGVTEFFEI CAN3_RAT 214 1 -
GCYEALSGGATTEGFEDFTGGIAEWYEL O54843 190 1 -
GSYEALKGGNTTEAMEDFTGGVTEFFEI O46596 213 1 -
GCYEALSGGATTEGFEDFTGGIAEWYEL CAN2_RAT 190 1 -
GSYEALKGGNTTEAMEDFTGGVTEFFEI O88977 194 1 -
GSYEALSGGCTSEAFEDFTGGVTEWYDL O35350 200 1 -
GSYEALKGGNTTEAMEDFTGGVAEFFEI CAN3_HUMAN 214 1 -
GCYEALSGGATTEGFEDFTGGIAEWYEL CAN2_HUMAN 190 1 -
GCYETLSGGATTEGFEDFTGGIAEWYEL CAN2_MOUSE 190 1 -
GSYEALSGGCTSEAFEDFTGGVTEWYDL O88666 200 1 -
GSYEALSGGCTSEAFEDFTGGVTEWYDL P97571 200 1 -
GSYEALSGGSTSEGFEDFTGGVTEWYEL CAN1_HUMAN 200 1 -
GSYEALKGGNTTEAMEDFTGGVIEFYEI CAN3_CHICK 208 1 -
GSYEALSGGTTTEGFEDFTGGIAEWYEL CAN2_CHICK 190 1 -
GCYEALSGGSTSEGFEDFTGGVTEWYDL O42133 200 1 -
GSYEALVGGSTIEGFEDFTGGISEFYDL Q64698 190 1 -
GCYESLSGGSTTEGFEDFTGGVAEMYDL CANX_CHICK 192 1 -
GSYEALKGGSAIEAMEDFTGGVAETFQT O14815 182 1 -
GSYEALKGGSTCEAMEDFTGGVSEWYDL CAN_DROME 228 1 -
GSYEALKGGTTSEALEDMTGGLTEFIDL YKR2_CAEEL 360 1 -
GCYQALDGGNTADALVDFTGGVSEPIDL O08688 172 1 -
GCYAHLSGGSQSEAMEDLTGGICLSLEL CAN_SCHMA 242 1 -
GCYQALDGGNTADALVDFTGGVSEPIDL O15484 171 1 -
GCYEALDGLTITDIIMDFTGTLAEIIDM O35646 172 1 -
GCYENLVGGHLSDALQDVSGGVAETLHV Q22036 172 1 -
GCYEALDGLTITDIIMDFTGTLAEIIDM O88501 172 1 -

Motif 7 width=22
Element Seqn Id St Int Rpt
EDGEFWMSYDDFVYHFTKLEIC O08702 325 103 -
EDGEFWMSYDDFVYHFTKLEIC O70376 325 103 -
EDGEFWMSYDDFVYHFTKLEIC O70482 373 151 -
EDGEFWMSYDDFVYHFTKLEIC CAN3_MOUSE 393 151 -
EDGEFWMSYDDFVYHFTKLEIC CAN3_RAT 393 151 -
EDGEFWMSFSDFLRHYSRLEIC O54843 320 102 -
EDGEFWMSYDDFIYHFTKLEIC O46596 393 152 -
EDGEFWMSFSDFLRHYSRLEIC CAN2_RAT 320 102 -
EDGEFWMSYDDFVYHFTKLEIC O88977 325 103 -
EDGEFWMSFRDFIREFTKLEIC O35350 330 102 -
EDGEFWMSYEDFIYHFTKLEIC CAN3_HUMAN 393 151 -
EDGEFWMSFSDFLRHYSRLEIC CAN2_HUMAN 320 102 -
EDGEFWMSFSDFLRHYSRLEIC CAN2_MOUSE 320 102 -
EDGEFWMSFRDFIREFTKLEIC O88666 330 102 -
EDGEFWMSFRDFIREFTKLEIC P97571 330 102 -
EDGEFWMSFRDFMREFTRLEIC CAN1_HUMAN 330 102 -
EDGEFWISLEDFMRHFTKLEIC CAN3_CHICK 386 150 -
EDGEFWMAFNDFLRHYSRLEIC CAN2_CHICK 320 102 -
EDGEFWMSFRDFLREFTRLEIC O42133 330 102 -
EDGEFWMSFSDFLKQYSRLEIC Q64698 320 102 -
EDGEFWMSFRDFMREFSRLEIC CANX_CHICK 322 102 -
DDGEFWMAFKDFKAHFDKVEIC O14815 313 103 -
RDGEFWMSFQDFLNHFDRVEIC CAN_DROME 363 107 -
HDGEFWMSFDDFMRNFEKMEIC YKR2_CAEEL 491 103 -
DDGEFWMTFEDMCRYFTDIIKC O08688 319 119 -
ADGEFWMSYEDFVTCFSRVEVC CAN_SCHMA 373 103 -
DDGEFWMTFEDVCRYFTDIIKC O15484 318 119 -
DDGEFWMSLEDFCHNFHKLNVC O35646 319 119 -
DDGDFWMPWESFVHYFTDISLC Q22036 329 129 -
DDGEFWMSLEDFCHNFHKLNVC O88501 319 119 -

Motif 8 width=18
Element Seqn Id St Int Rpt
SAGGCRNFPDTFWTNPQY O08702 375 28 -
SAGGCRNFPDTFWTNPQY O70376 375 28 -
SAGGCRNFPDTFWTNPQY O70482 423 28 -
SAGGCRNFPDTFWTNPQY CAN3_MOUSE 443 28 -
SAGGCRNFPDTFWTNPQY CAN3_RAT 443 28 -
TAGGCRNYPNTFWMNPQY O54843 370 28 -
SAGGCRNFPDTFWTNPQY O46596 443 28 -
TAGGCRNYPNTFWMNPQY CAN2_RAT 370 28 -
SAGGCRNFPDTFWTNPQY O88977 375 28 -
TAGGCRNYPATFWVNPQF O35350 380 28 -
SAGGCRNFPDTFWTNPQY CAN3_HUMAN 443 28 -
TAGGCRNYPNTFWMNPQY CAN2_HUMAN 370 28 -
TAGGCRNYPNTFWMNPQY CAN2_MOUSE 370 28 -
TAGGCRNYPATFWVNPQF O88666 380 28 -
TAGGCRNYPATFWVNPQF P97571 380 28 -
TAGGCRNYPATFWVNPQF CAN1_HUMAN 380 28 -
SAGGCRNYPDTFWTNPQY CAN3_CHICK 436 28 -
TAGGCRNYPNTFWTNPQY CAN2_CHICK 370 28 -
TAGGCRNYPATFWINPQF O42133 380 28 -
TAGGCLNYPGTYWTNPQF Q64698 370 28 -
TAGGCRNNPATFWINPQF CANX_CHICK 372 28 -
TAGGCRNFLDTFWTNPQI O14815 363 28 -
TAGGCRNFLDTFWHNPQY CAN_DROME 417 32 -
TAGGCRNYINTFANNPQF YKR2_CAEEL 549 36 -
RSGGCINHKDTFFQNPQY O08688 373 32 -
NAGGCINNRTTYWTSPQF CAN_SCHMA 427 32 -
RGGGCINHKDTFFQNPQY O15484 372 32 -
RSGGCYNNRDTFLQNPQY O35646 370 29 -
RAGGCHNFKATFCNNPQY Q22036 386 35 -
RSGGCYNNRDTFLQNPQY O88501 370 29 -

Motif 9 width=29
Element Seqn Id St Int Rpt
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O08702 480 87 -
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O70376 480 87 -
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O70482 528 87 -
RLPPSEYVIVPSTYEPHQEGEFILRVFSE CAN3_MOUSE 548 87 -
RLPPSEYVIVPSTYEPHQEGEFILRVFSE CAN3_RAT 548 87 -
KLPPGEYVLVPSTFEPHKDGDFCIRVFSE O54843 476 88 -
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O46596 548 87 -
KLPPGEYVLVPSTFEPHKNGDFCIRVFSE CAN2_RAT 476 88 -
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O88977 480 87 -
RLPPGEYIVVPSTFEPNKEGDFLLRFFSE O35350 487 89 -
RLPPSEYVIVPSTYEPHQEGEFILRVFSE CAN3_HUMAN 548 87 -
KLPPGEYILVPSTFEPNKDGDFCIRVFSE CAN2_HUMAN 476 88 -
KLPPGEYVLVPSTFEPHKDGDFCIRVFSE CAN2_MOUSE 476 88 -
RPPPGEYIVVPSTFEPNKEGDFLLRFFSE O88666 487 89 -
RLPPGEYIVVPSTFEPNKEGDFLLRFFSE P97571 487 89 -
RLPPGEYVVVPSTFEPNKEGDFVLRFFSE CAN1_HUMAN 488 90 -
RLPPSEYVIIPSTYEPHQEGEFILRVFSE CAN3_CHICK 541 87 -
KLPAGEYIIVPSTFEPNLNGDFCLRVFSE CAN2_CHICK 476 88 -
RLPPGEYIVVPSTFEPNREGDFVLRVFSE O42133 489 91 -
RLPPGQYLVVPSTFEPFKDGDFCLRVFSE Q64698 478 90 -
RLPPGEYIVVPSTFEPHKEADFILRVFTE CANX_CHICK 478 88 -
KLPPGEYILIPSTFEPHQEADFCLRIFSE O14815 460 79 -
KLPPGHYLIVPSTFDPNEEGEFIIRVFSE CAN_DROME 519 84 -
RVPPGNYVVVPSTFEPNEEAEFMLRVYTN YKR2_CAEEL 619 52 -
ELPEGRYVIIPTTFEPGHTGEFLLRVFTD O08688 462 71 -
RVPPGSYVVIPSTFDPNIEVNFILRVFSQ CAN_SCHMA 524 79 -
DQPEGRYVIIPTTFEPGHTGEFLLRVFTD O15484 461 71 -
YLKKGSYVLVPTMFQHGRTSEFLLRIFSE O35646 461 73 -
SLPRGRYLLIPTTFAPKEQTLFMLRVYSD Q22036 475 71 -
YLKKGNYVLVPTMFQHGRTSEFLLRIFSE O88501 461 73 -