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PR00597

Identifier
GELSOLIN  [View Relations]  [View Alignment]  
Accession
PR00597
No. of Motifs
8
Creation Date
20-AUG-1996  (UPDATE 19-JUN-1999)
Title
Gelsolin family signature
Database References

PFAM; PF00626 Gelsolin
INTERPRO; IPR001974
Literature References
1. WEEDS, A.G., GOOCH, J., POPE, B. AND HARRIS, H.E.
Preparation and characterization of pig plasma and platelet gelsolins.
EUR.J.BIOCHEMISTRY 161 69-76 (1986).
 
2. WAY, M. AND WEEDS, A.
Nucleotide sequence of pig plasma gelsolin. Comparison of protein sequence
with human gelsolin and other actin-severing proteins shows strong
homologies and evidence for large internal repeats.
J.MOL.BIOL. 203 1127-1133 (1988).

Documentation
Gelsolin is a cytoplasmic, calcium-regulated, actin-modulating protein that 
binds to the barbed ends of actin filaments, preventing monomer exchange
(end-blocking or capping) [1]. It can promote nucleation (the assembly of
monomers into filaments), as well as sever existing filaments. In addition,
this protein binds with high affinity to fibronectin. Plasma gelsolin and
cytoplasmic gelsolin are derived from a single gene by alternate initiation 
sites and differential splicing.
 
Sequence comparisons indicate an evolutionary relationship between gelsolin,
villin, fragmin and severin [2]. Six large repeating segments occur in
gelsolin and villin, and 3 similar segments in severin and fragmin. While
the multiple repeats have yet to be related to any known function of the
actin-severing proteins, the superfamily appears to have evolved from an
ancestral sequence of 120 to 130 amino acid residues [2].
 
GELSOLIN is an 8-element fingerprint that provides a signature for the
gelsolins. The fingerprint was derived from an initial alignment of 11
sequences: the motifs were drawn from conserved regions within the
C-terminal half of the alignment, spanning the putative Ca-sensitive
actin-binding domain. Two iterations on OWL28.1 were required to reach
convergence, at which point a true set comprising 14 sequences was 
identified. Several partial matches were also found, all of which belong to
the actin-severing superfamily (including villins, fragmins, severins and
various actin regulatory proteins).
 
An update on SPTR37_9f identified a true set of 22 sequences, and 17
partial matches.
Summary Information
  22 codes involving  8 elements
2 codes involving 7 elements
5 codes involving 6 elements
4 codes involving 5 elements
3 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
82222222222222222
702222222
615345552
534431410
412331020
300110010
200000000
12345678
True Positives
ADSV_BOVIN    ADSV_MOUSE    GELS_HORSE    GELS_HUMAN    
GELS_MOUSE O15195 O22946 O61270
O65570 O70466 O75366 O81643
O81644 O81645 O88398 O93510
Q07171 Q27319 VIL1_HUMAN VIL1_MOUSE
VILI_CHICK VILI_DICDI
True Positive Partials
Codes involving 7 elements
O08990 Q94707
Codes involving 6 elements
FLIH_CAEEL Q21253 Q24020 Q24088
SEVE_DICDI
Codes involving 5 elements
O46385 O60611 O60612 Q13045
Codes involving 4 elements
CAPG_HUMAN CAPG_MOUSE QUAI_DROME
Codes involving 3 elements
Q27410
Sequence Titles
ADSV_BOVIN  ADSEVERIN (SCINDERIN) (SC) - BOS TAURUS (BOVINE). 
ADSV_MOUSE ADSEVERIN (GELSOLIN-LIKE PROTEIN) - MUS MUSCULUS (MOUSE).
GELS_HORSE GELSOLIN (ACTIN-DEPOLYMERIZING FACTOR) (ADF) (BREVIN) - EQUUS CABALLUS (HORSE).
GELS_HUMAN GELSOLIN PRECURSOR, PLASMA (ACTIN-DEPOLYMERIZING FACTOR) (ADF) (BREVIN) (AGEL) - HOMO SAPIENS (HUMAN).
GELS_MOUSE GELSOLIN (ACTIN-DEPOLYMERIZING FACTOR) (ADF) (BREVIN) - MUS MUSCULUS (MOUSE).
O15195 VILLIN-LIKE PROTEIN - HOMO SAPIENS (HUMAN).
O22946 VILLIN 2 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O61270 GELSOLIN, CYTOPLASMIC (ACTIN-DEPOLYMERIZING FACTOR) (ADF) (ASCIDIAN GELSOLIN) (80K PROTEIN) - HALOCYNTHIA RORETZI (SEA SQUIRT).
O65570 PROBABLE VILLIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O70466 PUTATIVE ACTIN-BINDING PROTEIN DOC6 - MUS MUSCULUS (MOUSE).
O75366 ADVILLIN (P92) - HOMO SAPIENS (HUMAN).
O81643 VILLIN 1 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O81644 VILLIN 2 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O81645 VILLIN 3 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O88398 ADVILLIN (P92) - MUS MUSCULUS (MOUSE).
O93510 HOMOGENIN - GALLUS GALLUS (CHICKEN).
Q07171 GELSOLIN PRECURSOR (ACTIN-DEPOLYMERIZING FACTOR) (ADF) (BREVIN) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q27319 GELSOLIN-LIKE PROTEIN, CYTOPLASMIC (ACTIN-DEPOLYMERIZING FACTOR) (ADF) - HOMARUS AMERICANUS (AMERICAN LOBSTER).
VIL1_HUMAN VILLIN - HOMO SAPIENS (HUMAN).
VIL1_MOUSE VILLIN - MUS MUSCULUS (MOUSE).
VILI_CHICK VILLIN - GALLUS GALLUS (CHICKEN).
VILI_DICDI PROTOVILLIN (100 KD ACTIN-BINDING PROTEIN) - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).

O08990 ADSEVERIN - MUS MUSCULUS (MOUSE).
Q94707 ACTIN-BINDING PROTEIN FRAGMIN P - PHYSARUM POLYCEPHALUM (SLIME MOLD).

FLIH_CAEEL FLIGHTLESS-I PROTEIN HOMOLOG - CAENORHABDITIS ELEGANS.
Q21253 K06A4.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q24020 FLIGHTLESS-I PROTEIN (FLII) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q24088 FLIGHTLESS-I PROTEIN (FLII) - DROSOPHILA MELANOGASTER (FRUIT FLY).
SEVE_DICDI SEVERIN - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).

O46385 SUPERVILLIN - BOS TAURUS (BOVINE).
O60611 SUPERVILLIN - HOMO SAPIENS (HUMAN).
O60612 SUPERVILLIN - HOMO SAPIENS (HUMAN).
Q13045 FLIGHTLESS-I PROTEIN HOMOLOG - HOMO SAPIENS (HUMAN).

CAPG_HUMAN MACROPHAGE CAPPING PROTEIN (ACTIN-REGULATORY PROTEIN CAP-G) - HOMO SAPIENS (HUMAN).
CAPG_MOUSE MACROPHAGE CAPPING PROTEIN (MYC BASIC MOTIF HOMOLOG-1) (ACTIN-CAPPING PROTEIN GCAP39) - MUS MUSCULUS (MOUSE).
QUAI_DROME VILLIN-LIKE PROTEIN QUAIL - DROSOPHILA MELANOGASTER (FRUIT FLY).

Q27410 EWAM (ACTIN-MODULATOR) - LUMBRICUS TERRESTRIS (COMMON EARTHWORM).
Scan History
OWL28_1    2  200  NSINGLE    
SPTR37_9f 7 250 NSINGLE
Initial Motifs
Motif 1  width=22
Element Seqn Id St Int Rpt
TQIQLLPEGGETPIFKQFFKDW BBSCINDE 326 326 -
TQIQVLPEGGETPIFKQFFKDW MMU04354 326 326 -
TQIQVLPEGGETPIFKQFFKDW A53209 326 326 -
TQVSVLPEGGETPLFKQFFKNW GELS_HUMAN 375 375 -
TQVSVLPEGGETPLFKQFFKNW GELS_MOUSE 323 323 -
TQVEVQNDGAESAVFQQLFQKW VIL1_HUMAN 327 327 -
TSVETENDGSESAVFRQLFQKW VILI_CHICK 328 328 -
TNVQRVVEKAEPAVFKAYFKTW S53373 325 325 -
TNVQRVVEKAEPAVFKAYFKTW S41391 325 325 -
TQVEVQNDGAESPIFQQLFQKW MUSVILLIN 328 328 -
TQVSVLPEGGETPLFKQFFKNW GELS_PIG 365 365 -

Motif 2 width=17
Element Seqn Id St Int Rpt
WLGHFYGGDCYLVLYTY VILI_CHICK 417 67 -
TYGQFYGGDSYIILYNY GELS_PIG 454 67 -
SYGEFYGGDCYIILYTY A53209 415 67 -
SYGEFYGGDCYIILYTY MMU04354 415 67 -
SYGEFYGGDCYIILYTY BBSCINDE 415 67 -
WLGHFYGGDCYLLLYTY MUSVILLIN 417 67 -
THGFFFGGDSYVLKYIY S41391 423 76 -
THGFFFGGDSYVLKYIY S53373 423 76 -
TYGQFYGGDSYIILYNY GELS_HUMAN 464 67 -
TYGQFYGGDSYIILYNY GELS_MOUSE 412 67 -
WLGHFYGGDCYLLLYTY VIL1_HUMAN 416 67 -

Motif 3 width=19
Element Seqn Id St Int Rpt
IIYNWQGAQSTQDEVAASA GELS_HUMAN 489 8 -
IIYNWQGAQSTQDEVAASA GELS_PIG 479 8 -
IIYTWQGANATRDELTTSA A53209 436 4 -
IIYTWQGANATRDELTMSA MMU04354 436 4 -
IIYTWQGANATRDELTTSD BBSCINDE 436 4 -
LLYIWQGSQASQDEIAASA MUSVILLIN 442 8 -
ILYFWQGCASSQDEKASSA S41391 448 8 -
ILYFWQGCASSQDEKASSA S53373 448 8 -
IIYIWQGRHASTDELAASA VILI_CHICK 442 8 -
LLYVWQGSQASQDEITASA VIL1_HUMAN 441 8 -
IIYNWQGAQSTQDEVAASA GELS_MOUSE 437 8 -

Motif 4 width=21
Element Seqn Id St Int Rpt
VQVRVVQGYEPAHFLRIFKGR S41391 481 14 -
VQIRVTMGKEPPHLMSIFKGR MUSVILLIN 475 14 -
VQIRVSQGKEPAHLLSLFKDK BBSCINDE 469 14 -
VQVRVTMGKEPAHLMAIFKGK VILI_CHICK 475 14 -
VQIRVPMGKEPPHLMSIFKGR VIL1_HUMAN 474 14 -
VQSRVVQGKEPAHLMSLFGGK GELS_MOUSE 470 14 -
VQSRVVQGKEPAHLMSLFGGK GELS_HUMAN 522 14 -
VQSRVVQGKEPAHLMSLFGGK GELS_PIG 512 14 -
VQVRVSQGKEPAHLLSLFKDK MMU04354 469 14 -
VQIRVSQGKEPAHLLSLFKDK A53209 469 14 -
VQVRVVQGYEPAHFLRIFKGR S53373 481 14 -

Motif 5 width=21
Element Seqn Id St Int Rpt
TKAFEVTARATSLNSNDVFIL MUSVILLIN 528 32 -
TRAIQQTEVAGSLNSDDVFVL S53373 540 38 -
TRIMEVDVDANSLNSNDVFVL A53209 523 33 -
TRAVEVIPKAGALNSNDAFVL GELS_PIG 566 33 -
TKAFEVPVRAASLNSNDVFVL VILI_CHICK 528 32 -
TKAFEVPARANFLNSNDVFVL VIL1_HUMAN 527 32 -
TRAVEVMPKSGALNSNDAFVL GELS_MOUSE 524 33 -
TRAVEVLPKAGALNSNDAFVL GELS_HUMAN 576 33 -
TRIVEVDVDANSLNSNDTFVL MMU04354 523 33 -
TRIMEVDVDANSLNSNDVFVL BBSCINDE 523 33 -
TRAIQQTEVAGSLNSDDVFVL S41391 540 38 -

Motif 6 width=20
Element Seqn Id St Int Rpt
EGSEPDGFWEALGGKAAYRT GELS_HUMAN 634 37 -
EGSEPDSFWEALGGKAAYRT GELS_PIG 624 37 -
EGKEPEEFWNSLGGKKDYQT A53209 582 38 -
EGKEPEEFWNSLGGRGDYQT MMU04354 582 38 -
EGKEPEEFWNSLGGKKDYQT BBSCINDE 582 38 -
EGQEPANFWMALGGKAPYAN MUSVILLIN 587 38 -
EGEEDDDFWGGLGGKGDYQT S41391 600 39 -
EGEEDDDFWGGLGGKGDYQT S53373 600 39 -
EGSEPDGFWEALGGKTSYRT GELS_MOUSE 582 37 -
EGQEPANFWMALGGKAPYAN VIL1_HUMAN 586 38 -
EGQEPPEFWVALGGKTSYAN VILI_CHICK 587 38 -

Motif 7 width=23
Element Seqn Id St Int Rpt
QEDLNEDDVMVLDSGDEVYVWVG S53373 653 33 -
QEDLNEDDVMVLDSGDEVYVWVG S41391 653 33 -
QDDLEEEDVFLLDVWDQVFFWIG MUSVILLIN 641 34 -
QEDLATDDVMLLDTWDQVFVWVG GELS_HUMAN 690 36 -
QEDLATDDVMLLDTWDQVFVWVG GELS_MOUSE 638 36 -
QDDLEEDDVFLLDVWDQVFFWIG VIL1_HUMAN 640 34 -
QDDLDENDVYLLDTWDQIFFWIG VILI_CHICK 641 34 -
QDDLAEDDVMLLDAWEQIFIWIG BBSCINDE 637 35 -
QDDLAEDDVMLLDAWEQIFIWIG MMU04354 637 35 -
QDDLAEDDVMLLDAWEQIFIWIG A53209 637 35 -
QEDLATDDVMLLDTWDQVFVWVG GELS_PIG 680 36 -

Motif 8 width=20
Element Seqn Id St Int Rpt
EKKAAATTVQEYLKTHPGNR MUSVILLIN 670 6 -
EKKESVKSAKMYLETDPSGR MMU04354 666 6 -
EKSESLKSAKIYLETDPSGR A53209 666 6 -
EKTEALTSAKRYIETDPANR GELS_PIG 709 6 -
EKTEALTSAKRYIETDPANR GELS_MOUSE 667 6 -
EKKAAATTAQEYLKTHPSGR VIL1_HUMAN 669 6 -
EKEAAAETAQEYLRSHPGSR VILI_CHICK 670 6 -
EKTEALTSAKRYIETDPANR GELS_HUMAN 719 6 -
EKEKAFTMAENYIKTDPTER S53373 682 6 -
EKEKAFTMAENYIKTDPTER S41391 682 6 -
EKSESLKSAKIYLETDPSGR BBSCINDE 666 6 -
Final Motifs
Motif 1  width=22
Element Seqn Id St Int Rpt
TNVETVNDGAESAMFKQLFQKW O70466 325 325 -
TNVETVNDGAESAMFKQLFQKW O88398 325 325 -
TQVSVLPEGGETPLFKQFFKNW GELS_HUMAN 375 375 -
TNVETVNDGAESAMFKQLFQKW O75366 325 325 -
TQVSVLPEGGETPLFKQFFKNW GELS_MOUSE 323 323 -
TQVSVLPEGGETPLFRQFFKNW GELS_HORSE 323 323 -
TQVEVQNDGAESAVFQQLFQKW VIL1_HUMAN 327 327 -
TQVEVQNDGAESPIFQQLFQKW VIL1_MOUSE 327 327 -
TQVQVLPESGETPLFKQFFKNW O93510 371 371 -
TSVETENDGSESAVFRQLFQKW VILI_CHICK 328 328 -
TQIQVLPEGGETPIFKQFFKDW ADSV_BOVIN 326 326 -
TQIQVLPEGGETPIFKQFFKDW ADSV_MOUSE 326 326 -
TNVEVVNDGAESAAFKQLFRTW O15195 156 156 -
TNVQRVVEKAEPAVFKAYFKTW Q27319 325 325 -
THVTRVIQGYESHSFKSNFDSW O22946 321 321 -
THVTRVIQGYESHSFKSNFDSW O81644 321 321 -
SKLTVLPEGGETANFKSLFTNW O61270 325 325 -
TRITRVIQGYEPHSFKSNFDSW O81645 323 323 -
TPIIKMTQGSENTLFKDKFKKG VILI_DICDI 385 385 -
TSLVLLTEGLENARFRSFFNKW O81643 324 324 -
TQIHRIVEGSESAPFKQYFDTW Q07171 376 376 -
SQMIRIIEGFETVPFRSKFESW O65570 323 323 -

Motif 2 width=17
Element Seqn Id St Int Rpt
WHGFFYGGDCYLVLYTY O70466 414 67 -
WHGFFYGGDCYLVLYTY O88398 414 67 -
TYGQFYGGDSYIILYNY GELS_HUMAN 464 67 -
WYGFFYGGDCYLVLYTY O75366 414 67 -
TYGQFYGGDSYIILYNY GELS_MOUSE 412 67 -
TYGQFYGGDSYIILYNY GELS_HORSE 412 67 -
WLGHFYGGDCYLLLYTY VIL1_HUMAN 416 67 -
WLGHFYGGDCYLLLYTY VIL1_MOUSE 416 67 -
TYGQFYGGDSYIILYDY O93510 460 67 -
WLGHFYGGDCYLVLYTY VILI_CHICK 417 67 -
SYGEFYGGDCYIILYTY ADSV_BOVIN 415 67 -
SYGEFYGGDCYIILYTY ADSV_MOUSE 415 67 -
RHGQLCAGNCYLVLYTY O15195 240 62 -
THGFFFGGDSYVLKYIY Q27319 423 76 -
DIGKLYSGDCYLVLYTY O22946 409 66 -
DIGKLYSGDCYLVLYTY O81644 409 66 -
LYGQFYGGDCYIIMYTP O61270 414 67 -
HVGKLYSGDCYLVLYTY O81645 411 66 -
EFGLFYNQSCYLVLFTL VILI_DICDI 488 81 -
DQTKLFTGDCYLVQYKY O81643 409 63 -
EKLPLLGFASYVLTYNY Q07171 475 77 -
DHSKFYSGDCYVFQYSY O65570 411 66 -

Motif 3 width=19
Element Seqn Id St Int Rpt
ILYIWQGRHASRDELAASA O70466 439 8 -
ILYIWQGRHASRDELAASA O88398 439 8 -
IIYNWQGAQSTQDEVAASA GELS_HUMAN 489 8 -
ILYIWQDRHASQDELAASA O75366 439 8 -
IIYNWQGAQSTQDEVAASA GELS_MOUSE 437 8 -
IIYNWQGAQSTQDEVAASA GELS_HORSE 437 8 -
LLYVWQGSQASQDEITASA VIL1_HUMAN 441 8 -
LLYIWQGSQASQDEIAASA VIL1_MOUSE 441 8 -
IIYTWQGAHSTQDEIATSA O93510 485 8 -
IIYIWQGRHASTDELAASA VILI_CHICK 442 8 -
IIYTWQGANATRDELTTSA ADSV_BOVIN 436 4 -
IIYTWQGANATRDELTMSA ADSV_MOUSE 436 4 -
ILYLWQGHQATADEIEALN O15195 265 8 -
ILYFWQGCASSQDEKASSA Q27319 448 8 -
FLSCWFGKKSIPEDQDTAI O22946 435 9 -
FLSCWFGKKSIPEDQDTAI O81644 435 9 -
VLYYWQGNKASINERTALP O61270 436 5 -
FLCCWFGKNSNQEDQETAV O81645 437 9 -
ILYYWQGRFSSSEDKGAAA VILI_DICDI 514 9 -
LLYVWIGCESIQQDRADAI O81643 434 8 -
LTYVWHGVKASAAARKRAF Q07171 501 9 -
LIGTWFGKQSVEEERGSAV O65570 436 8 -

Motif 4 width=21
Element Seqn Id St Int Rpt
VQVRVSMGKEPRHFMAIFKGK O70466 472 14 -
VQVRVSMGKEPRHFMAIFKGK O88398 472 14 -
VQSRVVQGKEPAHLMSLFGGK GELS_HUMAN 522 14 -
VQVRVRMGTEPRHFMAIFKGK O75366 472 14 -
VQSRVVQGKEPAHLMSLFGGK GELS_MOUSE 470 14 -
VQSRVVQGKEPAHLMSLFGGK GELS_HORSE 470 14 -
VQIRVPMGKEPPHLMSIFKGR VIL1_HUMAN 474 14 -
VQIRVTMGKEPPHLMSIFKGR VIL1_MOUSE 474 14 -
VQKRVVQGKEPPHLMSMFGGK O93510 518 14 -
VQVRVTMGKEPAHLMAIFKGK VILI_CHICK 475 14 -
VQIRVSQGKEPAHLLSLFKDK ADSV_BOVIN 469 14 -
VQVRVSQGKEPAHLLSLFKDK ADSV_MOUSE 469 14 -
VQEHVTMGSEPPHFLAIFQGQ O15195 298 14 -
VQVRVVQGYEPAHFLRIFKGR Q27319 481 14 -
VQGRIYEGKEPPQFVALFQPM O22946 468 14 -
VQGRIYEGKEPPQFVALFQPM O81644 468 14 -
SQIRVVQGTEPPHMMMLFGGK O61270 470 15 -
VQARIFEGKEPPQFVALFQHM O81645 470 14 -
IHVRTVQNKEPNHFLEHFQGR VILI_DICDI 547 14 -
VLCHIYQGNEPSRFFPMFQSL O81643 467 14 -
LLVQTNQGHEPRHFYKIFKGK Q07171 530 10 -
AQARIYEGKEPIQFFVIMQSF O65570 469 14 -

Motif 5 width=21
Element Seqn Id St Int Rpt
TKAVEVSASASSLNSNDVFLL O70466 525 32 -
TKAVEVSASASSLISNDVFLL O88398 525 32 -
TRAVEVLPKAGALNSNDAFVL GELS_HUMAN 576 33 -
TKAVEVPAFASSLNSNDVFLL O75366 525 32 -
TRAVEVMPKSGALNSNDAFVL GELS_MOUSE 524 33 -
TRAVEIIPKAGALNSNDAFVL GELS_HORSE 524 33 -
TKAFEVPARANFLNSNDVFVL VIL1_HUMAN 527 32 -
TKAFEVTARATSLNSNDVFIL VIL1_MOUSE 527 32 -
TRAVELDPAASQLNSNDAFVL O93510 572 33 -
TKAFEVPVRAASLNSNDVFVL VILI_CHICK 528 32 -
TRIMEVDVDANSLNSNDVFVL ADSV_BOVIN 523 33 -
TRIVEVDVDANSLNSNDTFVL ADSV_MOUSE 523 33 -
TRTMEVPARASSLNSSDIFLL O15195 351 32 -
TRAIQQTEVAGSLNSDDVFVL Q27319 540 38 -
NKAVQVETVATSLNSYECFLL O22946 518 29 -
NKAVQVETVATSLNSYECFLL O81644 531 42 -
CRAVEVPAKSSHLNSNDAFLL O61270 524 33 -
NKALQVEAVATSLNSYDCFLL O81645 533 42 -
IHSIQVEKAISSLDSNDSFIL VILI_DICDI 605 37 -
MQAIQVNLVATSLNSSYSYIL O81643 530 42 -
VHASEVAADSSSLASSDAFVL Q07171 575 24 -
MQAIQVDPVAASLNSSYYYIL O65570 532 42 -

Motif 6 width=20
Element Seqn Id St Int Rpt
EGQEPPEFWDLLGGKTAYAN O70466 584 38 -
EGQEPPEFWDLLGGKTAYAN O88398 584 38 -
EGSEPDGFWEALGGKAAYRT GELS_HUMAN 634 37 -
EGQEPAEFWDLLGGKTPYAN O75366 584 38 -
EGSEPDGFWEALGGKTSYRT GELS_MOUSE 582 37 -
EGSEPDSFWEALGGKATYRT GELS_HORSE 582 37 -
EGQEPANFWMALGGKAPYAN VIL1_HUMAN 586 38 -
EGQEPANFWMALGGKAPYAN VIL1_MOUSE 586 38 -
EGREPDNFWVALGGKAPYRT O93510 630 37 -
EGQEPPEFWVALGGKTSYAN VILI_CHICK 587 38 -
EGKEPEEFWNSLGGKKDYQT ADSV_BOVIN 582 38 -
EGKEPEEFWNSLGGRGDYQT ADSV_MOUSE 582 38 -
EGQEPPHFWEALGGRAPYPS O15195 410 38 -
EGEEDDDFWGGLGGKGDYQT Q27319 600 39 -
EGTESSTFWFALGGKQNFTS O22946 578 39 -
EGTESSTFWFALGGKQNFTS O81644 591 39 -
ENQEPNEFWTALGGQSDYWR O61270 583 38 -
EGTESSSFWFALGGKQNFTS O81645 593 39 -
EGDETSEFWESLETNSSLSL VILI_DICDI 665 39 -
EGNETDTFWNLLGGKSEYPK O81643 590 39 -
EGAEPDEFWEELNGEGQYDR Q07171 637 41 -
EGSESEQFWELLGGKAEYSS O65570 592 39 -

Motif 7 width=23
Element Seqn Id St Int Rpt
QEDLSPGDVMLLDTWDQVFLWIG O70466 638 34 -
QEDLSPGDVMLLDTWDQVFLWIG O88398 638 34 -
QEDLATDDVMLLDTWDQVFVWVG GELS_HUMAN 690 36 -
QDDLNPTDVMLLDTWDQVFLWIG O75366 638 34 -
QEDLATDDVMLLDTWDQVFVWVG GELS_MOUSE 638 36 -
QEDLATDDVMLLDTWDQVFVWVG GELS_HORSE 638 36 -
QDDLEEDDVFLLDVWDQVFFWIG VIL1_HUMAN 640 34 -
QDDLEEEDVFLLDVWDQVFFWIG VIL1_MOUSE 640 34 -
QDDLATDDVMILDTWDQVFVWIG O93510 686 36 -
QDDLDENDVYLLDTWDQIFFWIG VILI_CHICK 641 34 -
QDDLAEDDVMLLDAWEQIFIWIG ADSV_BOVIN 637 35 -
QDDLAEDDVMLLDAWEQIFIWIG ADSV_MOUSE 637 35 -
QEDLDKYDIMLLDTWQEIFLWLG O15195 464 34 -
QEDLNEDDVMVLDSGDEVYVWVG Q27319 653 33 -
QDDLLTEDIYFLDTHAEVFVWVG O22946 622 24 -
QDDLLTEDIYFLDTHAEVFVWVG O81644 643 32 -
QSDLNPDSIMMLDAWNYIYVWIG O61270 636 33 -
QDDLLTEEMHLLDTHAEVFVWVG O81645 645 32 -
QDDLDSDDVMILDNQKQIFVWVG VILI_DICDI 723 38 -
QDDLTTEDVFLLDCQSEVYVWIG O81643 642 32 -
QEDLDSDDIMLLDAGDEIYLWVG Q07171 691 34 -
QDDLMTEDIFIIDCHSEIFVWVG O65570 644 32 -

Motif 8 width=20
Element Seqn Id St Int Rpt
EKKGALSTAQEYLVTHPSGR O70466 667 6 -
EKKGALSTAQEYLVTHPSGR O88398 667 6 -
EKTEALTSAKRYIETDPANR GELS_HUMAN 719 6 -
EKESALATAQQYLHTHPSGR O75366 667 6 -
EKTEALTSAKRYIETDPANR GELS_MOUSE 667 6 -
EKTEALTSAKRYIDTDPAHR GELS_HORSE 667 6 -
EKKAAATTAQEYLKTHPSGR VIL1_HUMAN 669 6 -
EKKAAATTVQEYLKTHPGNR VIL1_MOUSE 669 6 -
EKTEALKSAKRYIETDPASR O93510 715 6 -
EKEAAAETAQEYLRSHPGSR VILI_CHICK 670 6 -
EKSESLKSAKIYLETDPSGR ADSV_BOVIN 666 6 -
EKKESVKSAKMYLETDPSGR ADSV_MOUSE 666 6 -
EWKEAVAWGQEYLKTHPAGR O15195 491 4 -
EKEKAFTMAENYIKTDPTER Q27319 682 6 -
EKQTVFEIGQKYIDLAGSLE O22946 651 6 -
EKQTVFEIGQKYIDLAGSLE O81644 672 6 -
EKMSFKSLVDNYVKTDGSGR O61270 665 6 -
EKQTAFEIGQRYINLAGSLE O81645 674 6 -
EKLMANETALEYIMNAPTHR VILI_DICDI 752 6 -
SKEEALTLGLKFLEMDILEE O81643 671 6 -
ENGKLLDTAKLYFNLEPTAR Q07171 720 6 -
NKLLALTIGEKFIEKDSLLE O65570 673 6 -