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PR00264

Identifier
INTERLEUKIN1  [View Relations]  [View Alignment]  
Accession
PR00264
No. of Motifs
3
Creation Date
20-OCT-1992  (UPDATE 14-MAY-2000)
Title
Interleukin-1 precursor family signature
Database References
PRINTS; PR00262 IL1HBGF; PR01360 INTRLEUKIN1X; PR01357 INTRLEUKN1AB

PROSITE; PS00253 INTERLEUKIN_1; PS00247 HBGF_FGF
BLOCKS; BL00253
PFAM; PF00340 interleukin-1
INTERPRO; IPR000975
PDB; 1ITA; 1I1B; 1IRA
SCOP; 1ITA; 1I1B; 1IRA
CATH; 1ITA; 1I1B; 1IRA
Literature References
1. OPPENHEIM, J.J., KOVACS, E.J., MATSUSHIMA, K. AND DURUM, S.K. 
There is more than one interleukin 1. 
IMMUNOL.TODAY 7 45-56 (1986).
 
2. ROTHWELL, N.J. AND LUHESHI, G.N.
Interleukin-1 in the brain: biology, pathology and therapeutic target.
TRENDS NEUROSCIENCE 23(12) 618-625 (2000).
 
3. EISENBERG, S.P., BREWER, M.T., VERDERBER, E., HEIMDAL, P., BRANDHUBER,
B.J. AND THOMPSON, R.C. 
Interleukin 1 receptor antagonist is a member of the interleukin 1 gene 
family: Evolution of a cytokine control mechanism. 
PROC.NATL.ACAD.SCI.U.S.A. 88 5232-5236 (1991). 
 
4. PRIESTLE, J.P., SCHAR, H.-P. AND GRUTTER, M.G. 
Crystallographic refinement of interleukin 1 beta at 2.0 angstrom 
resolution. 
PROC.NATL.ACAD.SCI.U.S.A. 86 9667-9671 (1989). 
 
5. MURZIN, A.G., LESK, A.M. AND CHOTHIA, C. 
Patterns of structure and sequence in the Kunitz inhibitors, interleukins-1
beta and 1 alpha and fibroblast growth factors. 
J.MOL.BIOL. 223 531-543 (1992). 

Documentation
Interleukin-1 (IL-1) is a cytokine with a wide range of biological and
physiological effects, including fever, prostaglandin synthesis (in e.g.,
fibroblasts, muscle and endothelial cells), T-lymphocyte activation, and 
interleukin-2 production [1]. This family is a member of a superfamily that
also contains the heparin binding growth factors (HBGF), the Kunitz-type 
soybean trypsin inhibitors (STI) and histactophilin. All have very similar
structures, but although the interleukin-1 and HBGF families share some
sequence similarity (about 25%), they show none at all to the STIs.
 
Over a hundred cytokines have now been identified, including several
putative new members of the IL-1 family [2]. The IL-1 family consists of 2
main classes, designated alpha (IL1A) and beta (IL1B), as well as the more
recently discovered IL-1 receptor antagonist (IL1RA). Sequence similarity 
is high within the IL1A and IL1B subfamilies (about 60-70%) but low between
them (less than 30%). IL1As and IL1Bs are synthesised as larger precursors, 
which are processed to give mature carboxy fragments. IL1B requires this 
cleavage to become biologically active, but IL1A precursor is already 
active. Both IL1A and IL1B bind to the same IL1-specific receptor on the 
target cell, which is then internalised to initiate the relevant effects
(which appear to be similar or identical).
 
IL1RA binds to the IL1 receptor, blocking the effects of IL1A and IL1B
whilst eliciting no response of its own. From sequence comparisons it seems
to have arisen by gene duplication before IL1 diverged into IL1A and IL1B,
as it has features of both [3]. It seems likely to have the same fold as
IL1A and IL1B. 
                
The crystal structures of IL1A and IL1B [4] have been solved, showing them 
to share the same 12-stranded beta-sheet structure as both the heparin
binding growth factors and the Kunitz-type soybean trypsin inhibitors [5].
The beta-sheets are arranged in 3 similar lobes around a central axis, 6
strands forming an anti-parallel beta-barrel. Several regions, especially 
the loop between strands 4 and 5, have been implicated in receptor binding.
 
INTERLEUKIN1 is a 3-element fingerprint that provides a signature for the
interleukin-1 precursor family. The fingerprint was derived from an initial
alignment of 28 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 1 encodes beta-strands
5 and 6; motif 2 spans alpha-helix 2 and strand 8; and motif 3 encompasses
strands 9 and 10. Two iterations on SPTR37_10f were required to reach
convergence, at which point a true set comprising 42 sequences was 
identified. A single partial match was also found, IL1A_CERTO, an IL-1
alpha precursor from the sooty mangabey that fails to match motif 2.
Summary Information
  42 codes involving  3 elements
1 codes involving 2 elements
Composite Feature Index
3424242
2101
123
True Positives
IL1A_BOVIN    IL1A_CANFA    IL1A_CAPHI    IL1A_FELCA    
IL1A_HORSE IL1A_HUMAN IL1A_MACFA IL1A_MACMU
IL1A_MOUSE IL1A_PIG IL1A_RABIT IL1A_RAT
IL1A_SHEEP IL1B_BOVIN IL1B_CAPHI IL1B_CEREL
IL1B_CERTO IL1B_FELCA IL1B_HORSE IL1B_HUMAN
IL1B_MACFA IL1B_MACMU IL1B_MACNE IL1B_MOUSE
IL1B_PIG IL1B_RABIT IL1B_RAT IL1B_SHEEP
IL1X_BOVIN IL1X_HORSE IL1X_HUMAN IL1X_MOUSE
IL1X_PIG IL1X_RABIT IL1X_RAT O57398
O70207 O73909 Q14628 Q29082
Q62161 Q9YGD3
True Positive Partials
Codes involving 2 elements
IL1A_CERTO
Sequence Titles
IL1A_BOVIN  INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - BOS TAURUS (BOVINE). 
IL1A_CANFA INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - CANIS FAMILIARIS (DOG).
IL1A_CAPHI INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - CAPRA HIRCUS (GOAT).
IL1A_FELCA INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - FELIS SILVESTRIS CATUS (CAT).
IL1A_HORSE INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - EQUUS CABALLUS (HORSE).
IL1A_HUMAN INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) (HEMATOPOIETIN-1) - HOMO SAPIENS (HUMAN).
IL1A_MACFA INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) (HEMATOPOIETIN-1) - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
IL1A_MACMU INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) (HEMATOPOIETIN-1) - MACACA MULATTA (RHESUS MACAQUE).
IL1A_MOUSE INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - MUS MUSCULUS (MOUSE).
IL1A_PIG INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - SUS SCROFA (PIG).
IL1A_RABIT INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - ORYCTOLAGUS CUNICULUS (RABBIT).
IL1A_RAT INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - RATTUS NORVEGICUS (RAT).
IL1A_SHEEP INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - OVIS ARIES (SHEEP).
IL1B_BOVIN INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - BOS TAURUS (BOVINE).
IL1B_CAPHI INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - CAPRA HIRCUS (GOAT).
IL1B_CEREL INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - CERVUS ELAPHUS (RED DEER).
IL1B_CERTO INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
IL1B_FELCA INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - FELIS SILVESTRIS CATUS (CAT).
IL1B_HORSE INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - EQUUS CABALLUS (HORSE).
IL1B_HUMAN INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) (CATABOLIN) - HOMO SAPIENS (HUMAN).
IL1B_MACFA INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
IL1B_MACMU INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - MACACA MULATTA (RHESUS MACAQUE).
IL1B_MACNE INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - MACACA NEMESTRINA (PIG-TAILED MACAQUE).
IL1B_MOUSE INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - MUS MUSCULUS (MOUSE).
IL1B_PIG INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - SUS SCROFA (PIG).
IL1B_RABIT INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) (LYMPHOCYTE PROLIFERATION POTENTIATING FACTOR) - ORYCTOLAGUS CUNICULUS (RABBIT).
IL1B_RAT INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - RATTUS NORVEGICUS (RAT).
IL1B_SHEEP INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) - OVIS ARIES (SHEEP).
IL1X_BOVIN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR (IL-1RA) (IL-1RN) (IRAP) - BOS TAURUS (BOVINE).
IL1X_HORSE INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR (IL-1RA) (IL-1RN) (IRAP) - EQUUS CABALLUS (HORSE).
IL1X_HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR (IL-1RA) (ICIL- 1RA) (IRAP) (IL-1RN) - HOMO SAPIENS (HUMAN).
IL1X_MOUSE INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR (IL-1RA) (IL-1RN) (IRAP) - MUS MUSCULUS (MOUSE).
IL1X_PIG INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR (IL-1RA) (IL-1RN) (IRAP) - SUS SCROFA (PIG).
IL1X_RABIT INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR (IL-1RA) (IL-1RN) (IRAP) - ORYCTOLAGUS CUNICULUS (RABBIT).
IL1X_RAT INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR (IL-1RA) (IL-1RN) (IRAP) - RATTUS NORVEGICUS (RAT).
O57398 INTERLEUKIN-1 BETA - CYPRINUS CARPIO (COMMON CARP).
O70207 INTRACELLULAR INTERLEUKIN-1 RECEPTOR ANTAGONIST - MUS MUSCULUS (MOUSE).
O73909 INTERLEUKIN-1BETA - GALLUS GALLUS (CHICKEN).
Q14628 INTRACELLULAR IL-1 RECEPTOR ANTAGONIST TYPE II - HOMO SAPIENS (HUMAN).
Q29082 INTERLEUKIN 1-BETA - SUS SCROFA (PIG).
Q62161 INTERLEUKIN-1 - MUS MUSCULUS (MOUSE).
Q9YGD3 INTERLEUKIN-1 BETA - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).

IL1A_CERTO INTERLEUKIN-1 ALPHA PRECURSOR (IL-1 ALPHA) - CERCOCEBUS TORQUATUS ATYS (RED-CROWNED MANGABEY) (SOOTY MANGABEY).
Scan History
SPTR37_10f 2  100  NSINGLE    
Initial Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
IPVALGIKDKNLYLSCVKKGD IL1B_BOVIN 169 169 -
IPVALGLKAKNLYLSCVLKDD IL1B_MACFA 172 172 -
IPVALGLKAKNLYLSCVLKDD IL1B_MACNE 172 172 -
IPVALGLKAKNLYLSCVLKDD IL1B_MACMU 172 172 -
IPVALGLKEKNLYLSCVLKDD IL1B_HUMAN 172 172 -
IPVTLGIKGKNLYLSCVMKDN IL1B_PIG 170 170 -
IPVALGLRGKNLYLSCVMKDD IL1B_RABIT 171 171 -
IPVALGIRDKNLYLSCVKKGD IL1B_SHEEP 169 169 -
IPVALGLKGKNLYLSCVMKDG IL1B_MOUSE 173 173 -
IPVALGLKGLNLYLSCVMKDG IL1B_RAT 172 172 -
VPVALGLKAKNLYLSCVLKDD IL1B_CERTO 172 172 -
IPVALGIRDKNQYLSCVKKGD IL1B_CEREL 169 169 -
IPVVLCIKKNNLYLSCVMKDG IL1B_FELCA 171 171 -
HSVFLGIHGGKLCLSCAKSGD IL1X_MOUSE 80 80 -
VPVILRISKTQLYVSAQDEDQ IL1A_MACFA 180 180 -
VPVILRISKTQLYVSAQDEDQ IL1A_MACMU 180 180 -
RNVFLGIHGGKLCLSCVKSGD IL1X_RAT 80 80 -
LPVTLRISKTQLFVSAQNEDE IL1A_BOVIN 180 180 -
LPVTLRISKTQLFVSAQNEDE IL1A_SHEEP 180 180 -
LPVTLRISETRLFVSAQNEDE IL1A_PIG 180 180 -
MPVALGIKGYKLYMSCVMSGT O73909 170 170 -
HALFLGIHGGKMCLSCVKSGD IL1X_HUMAN 79 79 -
ITVILRISKTQLYVTAQDEDQ IL1A_HUMAN 180 180 -
QLLFLGIQRGKLCLSCVKSGD IL1X_RABIT 79 79 -
LPVTLRISQTPLFVSAQNEDE IL1A_RABIT 180 180 -
YPVTLKISDSQLFVSAQGEDQ IL1A_MOUSE 183 183 -
YPVTLKVSNTQLFVSAQGEDK IL1A_RAT 183 183 -
QPVCLGISNSNLYLACTQLDG O57398 175 175 -

Motif 2 width=14
Element Seqn Id St Int Rpt
MEKRFVFYKTEIKN IL1B_BOVIN 208 18 -
MEKRFVFNKIEINN IL1B_MACFA 211 18 -
MEKRFVFNKIEINN IL1B_MACNE 211 18 -
MEKRFVFNKIEINN IL1B_MACMU 211 18 -
MEKRFVFNKIEINN IL1B_HUMAN 211 18 -
MEKRFVFYKTEIKN IL1B_PIG 209 18 -
MEKRFVFNKIEIKD IL1B_RABIT 210 18 -
MEKRFVFYKTEIKN IL1B_SHEEP 208 18 -
MEKRFVFNKIEVKS IL1B_MOUSE 212 18 -
MEKRFVFNKIEVKT IL1B_RAT 211 18 -
MEKRFVFNKIEINN IL1B_CERTO 211 18 -
MEKRFVFYKTEIKD IL1B_CEREL 208 18 -
MEKRFVFNKTEIKG IL1B_FELCA 210 18 -
EDKRFTFIRSEKGP IL1X_MOUSE 120 19 -
SETNFLFFWETHGT IL1A_MACFA 217 16 -
SETNFLFFWETHGT IL1A_MACMU 217 16 -
EDKRFTFIRSETGP IL1X_RAT 120 19 -
DETNLLFFWEKHGS IL1A_BOVIN 216 15 -
DETNLLFFWEKHGS IL1A_SHEEP 216 15 -
DETSLLFFWEKHGN IL1A_PIG 216 15 -
ELTRFIFYRLDSPT O73909 209 18 -
QDKRFAFIRSDSGP IL1X_HUMAN 119 19 -
SETNLLFFWETHGT IL1A_HUMAN 217 16 -
QDKRFTFIRSNSGP IL1X_RABIT 119 19 -
SESDILFFWETQGN IL1A_RABIT 217 16 -
SETDLIFFWKSINS IL1A_MOUSE 220 16 -
SETDLIFFWEKINS IL1A_RAT 220 16 -
PNDSLLFFRKETGT O57398 217 21 -

Motif 3 width=16
Element Seqn Id St Int Rpt
TVEFESVLYPNWYIST IL1B_BOVIN 222 0 -
KLEFESAQFPNWYIST IL1B_MACFA 225 0 -
KLEFESAQFPNWYIST IL1B_MACNE 225 0 -
KLEFESAQFPNWYIST IL1B_MACMU 225 0 -
KLEFESAQFPNWYIST IL1B_HUMAN 225 0 -
RVEFESALYPNWYIST IL1B_PIG 223 0 -
KLEFESAQFPNWYIST IL1B_RABIT 224 0 -
TVEFESVLYPNWYIST IL1B_SHEEP 222 0 -
KVEFESAEFPNWYIST IL1B_MOUSE 226 0 -
KVEFESAQFPNWYIST IL1B_RAT 225 0 -
KLECESAQFPNWYIST IL1B_CERTO 225 0 -
TVEFESVLYPNWYIST IL1B_CEREL 222 0 -
NVEFESSQFPNWYIST IL1B_FELCA 224 0 -
TTSFESAACPGWFLCT IL1X_MOUSE 134 0 -
KNYFISVAHPNLFIAT IL1A_MACFA 231 0 -
KNYFISVAHPNLFIAT IL1A_MACMU 231 0 -
TTSFESLACPGWFLCT IL1X_RAT 134 0 -
MDYFKSVAHPKLFIAT IL1A_BOVIN 230 0 -
MDYFKSVAHPKLFIAT IL1A_SHEEP 230 0 -
MDYFKSAAHPKLFIAT IL1A_PIG 230 0 -
TTRFESAAFPGWFICT O73909 225 2 -
TTSFESAACPGWFLCT IL1X_HUMAN 133 0 -
KNYFTSVAHPNLFIAT IL1A_HUMAN 231 0 -
TTTFESASCPGWFLCT IL1X_RABIT 133 0 -
KNYFKSAANPQLFIAT IL1A_RABIT 231 0 -
KNYFTSAAYPELFIAT IL1A_MOUSE 234 0 -
KNYFTSAAFPELLIAT IL1A_RAT 234 0 -
YNTFESVKYPGWFIST O57398 232 1 -
Final Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
IPVTLGIKGKNLYLSCVMKDD Q29082 170 170 -
IPVALGIKDKNLYLSCVKKGD IL1B_BOVIN 169 169 -
IPVALGLKAKNLYLSCVLKDD IL1B_MACFA 172 172 -
IPVALGLKAKNLYLSCVLKDD IL1B_MACNE 172 172 -
IPVALGLKAKNLYLSCVLKDD IL1B_MACMU 172 172 -
IPVALGLKEKNLYLSCVLKDD IL1B_HUMAN 172 172 -
IPVTLGIKGKNLYLSCVMKDN IL1B_PIG 170 170 -
IPVALGLRGKNLYLSCVMKDD IL1B_RABIT 171 171 -
IPVALGIRDKNLYLSCVKKGD IL1B_SHEEP 169 169 -
IPVALGLKGKNLYLSCVMKDG IL1B_MOUSE 173 173 -
IPVALGIRDKNLYLSWVKKGD IL1B_CAPHI 169 169 -
IPVALGLKGLNLYLSCVMKDG IL1B_RAT 172 172 -
VPVALGLKAKNLYLSCVLKDD IL1B_CERTO 172 172 -
IPVALGIRDKNQYLSCVKKGD IL1B_CEREL 169 169 -
IPVALGLKEKNLYLSCGMKDG IL1B_HORSE 171 171 -
IPVVLCIKKNNLYLSCVMKDG IL1B_FELCA 171 171 -
HFVFLGIHGGKLCLSCVKSGD IL1X_PIG 79 79 -
HSVFLGIHGGKLCLSCAKSGD IL1X_MOUSE 80 80 -
HSVFLGIHGGKLCLSCAKSGD O70207 61 61 -
VPVILRISKTQLYVSAQDEDQ IL1A_MACFA 180 180 -
VPVILRISKTQLYVSAQDEDQ IL1A_MACMU 180 180 -
RNVFLGIHGGKLCLSCVKSGD IL1X_RAT 80 80 -
LPVTLRISKTRLFVSAQNEDE IL1A_FELCA 180 180 -
LPVTLRISKTRLFVSAQNEDE IL1A_HORSE 180 180 -
LPVTLRISKTQLFVSAQNEDE IL1A_BOVIN 180 180 -
LPVTLRISKTQLFVSAQNEDE IL1A_SHEEP 180 180 -
LPVTLRISKTQLFVSAQNEDE IL1A_CAPHI 180 180 -
LPVTLRISKTRLFVSAQNEDE IL1A_CANFA 175 175 -
LPVTLRISETRLFVSAQNEDE IL1A_PIG 180 180 -
MPVALGIKGYKLYMSCVMSGT O73909 170 170 -
HALFLGIHGGKMCLSCVKSGD IL1X_HUMAN 79 79 -
HALFLGIHGGKMCLSCVKSGD Q14628 82 82 -
ITVILRISKTQLYVTAQDEDQ IL1A_HUMAN 180 180 -
QLLFLGIQRGKLCLSCVKSGD IL1X_RABIT 79 79 -
HTMFLGIHGGKLCLACVKSGD IL1X_BOVIN 77 77 -
LPVTLRISQTPLFVSAQNEDE IL1A_RABIT 180 180 -
YPVTLKISDSQLFVSAQGEDQ IL1A_MOUSE 183 183 -
YPVTLKISDSQLFVSAQGEDQ Q62161 74 74 -
DALFLGLHGRKLCLACVKSGD IL1X_HORSE 79 79 -
YPVTLKVSNTQLFVSAQGEDK IL1A_RAT 183 183 -
RPVALGIKGSNLYLSCSKSGG Q9YGD3 157 157 -
QPVCLGISNSNLYLACTQLDG O57398 175 175 -

Motif 2 width=14
Element Seqn Id St Int Rpt
MEKRFVFYKTEIKN Q29082 209 18 -
MEKRFVFYKTEIKN IL1B_BOVIN 208 18 -
MEKRFVFNKIEINN IL1B_MACFA 211 18 -
MEKRFVFNKIEINN IL1B_MACNE 211 18 -
MEKRFVFNKIEINN IL1B_MACMU 211 18 -
MEKRFVFNKIEINN IL1B_HUMAN 211 18 -
MEKRFVFYKTEIKN IL1B_PIG 209 18 -
MEKRFVFNKIEIKD IL1B_RABIT 210 18 -
MEKRFVFYKTEIKN IL1B_SHEEP 208 18 -
MEKRFVFNKIEVKS IL1B_MOUSE 212 18 -
MEKRFVFYKTEIKN IL1B_CAPHI 208 18 -
MEKRFVFNKIEVKT IL1B_RAT 211 18 -
MEKRFVFNKIEINN IL1B_CERTO 211 18 -
MEKRFVFYKTEIKD IL1B_CEREL 208 18 -
MEKRFVFNKMEIKG IL1B_HORSE 210 18 -
MEKRFVFNKTEIKG IL1B_FELCA 210 18 -
QDKRFTFIRSDSGP IL1X_PIG 119 19 -
EDKRFTFIRSEKGP IL1X_MOUSE 120 19 -
EDKRFTFIRSEKGP O70207 101 19 -
SETNFLFFWETHGT IL1A_MACFA 217 16 -
SETNFLFFWETHGT IL1A_MACMU 217 16 -
EDKRFTFIRSETGP IL1X_RAT 120 19 -
DETNLLFFWERHGS IL1A_FELCA 216 15 -
DETNLLFFWERHGS IL1A_HORSE 216 15 -
DETNLLFFWEKHGS IL1A_BOVIN 216 15 -
DETNLLFFWEKHGS IL1A_SHEEP 216 15 -
DETNLLFFWEKHGS IL1A_CAPHI 216 15 -
DETNLLFFWERHGS IL1A_CANFA 211 15 -
DETSLLFFWEKHGN IL1A_PIG 216 15 -
ELTRFIFYRLDSPT O73909 209 18 -
QDKRFAFIRSDSGP IL1X_HUMAN 119 19 -
QDKRFAFIRSDSGP Q14628 122 19 -
SETNLLFFWETHGT IL1A_HUMAN 217 16 -
QDKRFTFIRSNSGP IL1X_RABIT 119 19 -
QDKRFAFIRFDNGP IL1X_BOVIN 117 19 -
SESDILFFWETQGN IL1A_RABIT 217 16 -
SETDLIFFWKSINS IL1A_MOUSE 220 16 -
SETDLIFFWKSINS Q62161 111 16 -
ENKRFTFIRSNSGP IL1X_HORSE 119 19 -
SETDLIFFWEKINS IL1A_RAT 220 16 -
DMVRFLFYRRNTGV Q9YGD3 200 22 -
PNDSLLFFRKETGT O57398 217 21 -

Motif 3 width=16
Element Seqn Id St Int Rpt
RVEFESALYPNWYIST Q29082 223 0 -
TVEFESVLYPNWYIST IL1B_BOVIN 222 0 -
KLEFESAQFPNWYIST IL1B_MACFA 225 0 -
KLEFESAQFPNWYIST IL1B_MACNE 225 0 -
KLEFESAQFPNWYIST IL1B_MACMU 225 0 -
KLEFESAQFPNWYIST IL1B_HUMAN 225 0 -
RVEFESALYPNWYIST IL1B_PIG 223 0 -
KLEFESAQFPNWYIST IL1B_RABIT 224 0 -
TVEFESVLYPNWYIST IL1B_SHEEP 222 0 -
KVEFESAEFPNWYIST IL1B_MOUSE 226 0 -
TVEFESVLYPNWYIST IL1B_CAPHI 222 0 -
KVEFESAQFPNWYIST IL1B_RAT 225 0 -
KLECESAQFPNWYIST IL1B_CERTO 225 0 -
TVEFESVLYPNWYIST IL1B_CEREL 222 0 -
NVEFESAMYPNWYIST IL1B_HORSE 224 0 -
NVEFESSQFPNWYIST IL1B_FELCA 224 0 -
TTSFESAACPGWFLCT IL1X_PIG 133 0 -
TTSFESAACPGWFLCT IL1X_MOUSE 134 0 -
TTSFESAACPGWFLCT O70207 115 0 -
KNYFISVAHPNLFIAT IL1A_MACFA 231 0 -
KNYFISVAHPNLFIAT IL1A_MACMU 231 0 -
TTSFESLACPGWFLCT IL1X_RAT 134 0 -
KNYFKSVAHPKLFIAT IL1A_FELCA 230 0 -
KNYFKSVAHPKLFIAT IL1A_HORSE 230 0 -
MDYFKSVAHPKLFIAT IL1A_BOVIN 230 0 -
MDYFKSVAHPKLFIAT IL1A_SHEEP 230 0 -
MDYFKSVAHPKLFIAT IL1A_CAPHI 230 0 -
KHYFKSVAQPKLFIAT IL1A_CANFA 225 0 -
MDYFKSAAHPKLFIAT IL1A_PIG 230 0 -
TTRFESAAFPGWFICT O73909 225 2 -
TTSFESAACPGWFLCT IL1X_HUMAN 133 0 -
TTSFESAACPGWFLCT Q14628 136 0 -
KNYFTSVAHPNLFIAT IL1A_HUMAN 231 0 -
TTTFESASCPGWFLCT IL1X_RABIT 133 0 -
TTSFESAACPGWFLCT IL1X_BOVIN 131 0 -
KNYFKSAANPQLFIAT IL1A_RABIT 231 0 -
KNYFTSAAYPELFIAT IL1A_MOUSE 234 0 -
KNYFTSAAYPELFIAT Q62161 125 0 -
TTSFESAACPGWFLCT IL1X_HORSE 133 0 -
KNYFTSAAFPELLIAT IL1A_RAT 234 0 -
ISTLESASFRNWFIST Q9YGD3 215 1 -
YNTFESVKYPGWFIST O57398 232 1 -