| Literature References | 1. MAUCUER, A., DOYE, V. AND SOBEL, A.
A single amino acid difference distinguishes the human and the rat
sequences of stathmin, a ubiquitous intracellular phosphoprotein
associated with cell regulation.
FEBS LETT. 264 275-278 (1990).
2. MAUCUER, A., MOREAU, J., MECHALI, M. AND SOBEL, A.
Stathmin gene family: phylogenetic conservation and developmental
regulation in Xenopus.
J.BIOL.CHEM. 268 16420-16429 (1993).
3. DOYE, V., SOUBRIER, F., BAUW, G., BOUTTERIN, M.C., BERETTA, L.,
KOPPEL, J., VANDEKERCKHOVE, J. AND SOBEL, A.
A single cDNA encodes two isoforms of stathmin, a developmentally
regulated neuron-enriched phosphoprotein.
J.BIOL.CHEM. 264 12134-12137 (1989).
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| Documentation | Stathmin is a ubiquitous phosphorylated protein thought to act as an
intracellular relay for diverse regulatory pathways [1], functioning
through a variety of second messengers. Its phosphorylation and gene
expression are regulated throughout development [2] and in response to
extracellular signals regulating cell proliferation, differentiation and
function [3]. Stathmin, and the related proteins SCG10 and XB3, contains a
N-terminal domain (XB3 contains an additional N-terminal hydrophobic
region), a 78 amino acid coiled-coil region, and a short C-terminal domain.
STATHMIN is a 5-element fingerprint that provides a signature for
stathmins. The fingerprint was derived from an initial alignment of 4
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, motif 2 including the region encoded by PROSITE
pattern STATHMIN (PS00563), which corresponds to a well-conserved deca-
peptide containing the first 3 coiled coil residues. Two iterations on
OWL24.0 were required to reach convergence, at which point a true set
comprising 9 sequences was identified.
An update on SPTR37_9f identified a true set of 17 sequences.
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