| Literature References | 1. CRABB, J.W., JOHNSON, C.M., CARR, S.A., ARMES, L.G. AND SAARI, J.C.
The complete primary structure of the cellular retinaldehyde-binding
protein from bovine retina.
J.BIOL.CHEM. 263 18678-18687 (1988).
2. CRABB, J.W., JOHNSON, C.M., CARR, S.A., ARMES, L.G. AND SAARI, J.C.
Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein
from bovine and human retina and comparison of the protein structures.
J.BIOL.CHEM. 263 18688-18692 (1988).
3. SATO, Y., ARAI, H., MIYATA, A., TOKITA, S., YAMAMOTO, K., TANABE, T.
AND INOUE, K.
Primary structure of alpha-tocopherol transfer protein from rat liver.
Homology with cellular retinaldehyde-binding protein.
J.BIOL.CHEM. 268 17705-17710 (1993).
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| Documentation | Cellular retinaldehyde-binding protein (CRALBP) carries 11-cis-retinol and
11-cis-retinaldehyde as endogenous ligands: it is found only in visual
tissue, where it serves as a stereo-selective agent and/or a substrate
carrier protein [1]. CRALBP can protect its substrate from photo-isomeris-
ation, suggesting a possible role in the generation of 11-cis-retinols in
the visual cycle [2]. Sequence studies have revealed no similarities either
to other lipophile-binding proteins (such as fatty-acid binding proteins)
or to other retinoid-binding proteins (such as rhodopsin or cone visual
pigments) [1]. The location of the binding site and exact function of
CRALBP are still unclear [1,2].
Alpha-tocopherol transport protein is known to share sequence similarity
with CRALBP [3]. This protein binds only alpha-tocopherol (and not the
gamma form), and as such displays the same sort of stereo-selective
binding as implicated with CRALBP [3].
CRETINALDHBP is a 5-element fingerprint that provides a signature for
cellular retinaldehyde binding and alpha-tocopherol transport proteins.
The fingerprint was derived from an initial alignment of 3 sequences:
the motifs were drawn from conserved regions spanning virtually the full
alignment length. A single iteration on OWL25.1 was required to reach
convergence, no further sequences being identified beyond the starting set.
An update on SPTR37_9f identified a true set of 4 sequences, and 3
partial matches.
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