WORKLIST ENTRIES (1):

GLHYDRLASE4 View alignment      Glycosyl hydrolase family 4 signature
 Type of fingerprint: COMPOUND with 7  elements
Links:
   PRINTS; PR00131 GLHYDRLASE1; PR00132 GLHYDRLASE2; PR00133 GLHYDRLASE3
   PRINTS; PR00733 GLHYDRLASE6; PR00734 GLHYDRLASE7; PR00735 GLHYDRLASE8
   PRINTS; PR00134 GLHYDRLASE10; PR00911 GLHYDRLASE11; PR00736 GLHYDRLASE15
   PRINTS; PR00737 GLHYDRLASE16; PR00738 GLHYDRLASE20; PR00739 GLHYDRLASE26
   PRINTS; PR00740 GLHYDRLASE27; PR00741 GLHYDRLASE29; PR00843 GLHYDRLASE30
   PRINTS; PR00742 GLHYDRLASE35; PR00743 GLHYDRLASE36; PR00744 GLHYDRLASE37
   PRINTS; PR00745 GLHYDRLASE39; PR00746 GLHYDRLASE41; PR00747 GLHYDRLASE47
   PRINTS; PR00844 GLHYDRLASE48; PR00845 GLHYDRLASE52; PR00846 GLHYDRLASE56
   PRINTS; PR00849 GLHYDRLASE58; PR00850 GLHYDRLASE59; PR00748 MELIBIASE
   PRINTS; PR00137 LYSOZYME; PR00684 T4LYSOZYME; PR00749 LYSOZYMEG
   PRINTS; PR00110 ALPHAAMYLASE; PR00750 BETAAMYLASE
   INTERPRO; IPR001088
   PROSITE; PS01324 GLYCOSYL_HYDROL_F4

 Creation date 26-MAY-1997; UPDATE 07-JUN-1999

   1. HENRISSAT, B. AND BAIROCH, A.
   New families in the classification of glycosyl hydrolases based on amino
   acid sequence similarities.
   BIOCHEM.J. 293 781-788 (1993).

   2. HENRISSAT, B.
   A classification of glycosyl hydrolases based on amino acid sequence
   similarities.
   BIOCHEM.J. 280 309-316 (1991).

   3. DAVIES, G. AND HENRISSAT, B.
   Structures and mechanisms of glycosyl hydrolases.
   STRUCTURE 3 853-859 (1995).

   4. HENRISSAT, B. AND BAIROCH, A.
   Updating the sequence-based classification of glycosyl hydrolases.
   BIOCHEM.J. 316 695-696 (1996).

   O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that
   hydrolyse the glycosidic bond between two or more carbohydrates, or between
   a carbohydrate and a non-carbohydrate moiety. A classification system for
   glycosyl hydrolases, based on sequence similarity, has led to the definition
   of up to 60 different families [1-4] (http://expasy.hcuge.ch/cgi-bin/lists?
   glycosid.txt). Family 4 includes 6-phospho-beta-glucosidases, alpha-
   galactosidases, and B.subtilis LPLD protein. 
  
   GLHYDRLASE4 is a 7-element fingerprint that provides a signature for 
   family 4 glycosyl hydrolases. The fingerprint was derived from an initial
   alignment of 7 sequences: the motifs were drawn from short conserved regions 
   spanning the N-terminal half of the alignment. A single iteration on OWL29.3
   was required to reach convergence, no further sequences being identified
   beyond the starting set.
  
   An update on SPTR37_9f identified a true set of 8 sequences, and 1
   partial match.

  SUMMARY INFORMATION
      8 codes involving  7 elements
      1 codes involving  6 elements
      0 codes involving  5 elements
      0 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    7|   8    8    8    8    8    8    8  
    6|   0    1    1    1    1    1    1  
    5|   0    0    0    0    0    0    0  
    4|   0    0    0    0    0    0    0  
    3|   0    0    0    0    0    0    0  
    2|   0    0    0    0    0    0    0  
   --+------------------------------------
     |   1    2    3    4    5    6    7  

True positives..
 GLVG_BACSU     GLVG_ECOLI     MALH_FUSMR     CELF_BACSU     
 CELF_ECOLI     AGAL_BACSU     AGAL_ECOLI     LPLD_BACSU     
Subfamily:  Codes involving 6 elements
 Subfamily True positives..
 O88026         


  PROTEIN TITLES
   GLVG_BACSU       MALTOSE-6'-PHOSPHATE GLUCOSIDASE (EC 3.2.1.122) (6-PHOSPHO-A
   GLVG_ECOLI       PROBABLE 6-PHOSPHO-BETA-GLUCOSIDASE (EC 3.2.1.86) - ESCHERIC
   MALH_FUSMR       MALTOSE-6'-PHOSPHATE GLUCOSIDASE (EC 3.2.1.122) (6-PHOSPHO-A
   CELF_BACSU       PROBABLE 6-PHOSPHO-BETA-GLUCOSIDASE (EC 3.2.1.86) - BACILLUS
   CELF_ECOLI       6-PHOSPHO-BETA-GLUCOSIDASE (EC 3.2.1.86) - ESCHERICHIA COLI.
   AGAL_BACSU       ALPHA-GALACTOSIDASE (EC 3.2.1.22) (MELIBIASE) - BACILLUS SUB
   AGAL_ECOLI       ALPHA-GALACTOSIDASE (EC 3.2.1.22) (MELIBIASE) - ESCHERICHIA 
   LPLD_BACSU       LPLD PROTEIN - BACILLUS SUBTILIS.
 
   O88026           PUTATIVE GLUCOSIDASE - STREPTOMYCES COELICOLOR.

SCAN HISTORY OWL29_3 1 100 NSINGLE SPTR37_9f 2 14 NSINGLE INITIAL MOTIF SETS GLHYDRLASE41 Length of motif = 16 Motif number = 1 Glycosyl hydrolase family 4 motif I - 1 PCODE ST INT KIVTIGGGSSYTPELV CELF_BACSU 6 6 KVVTIGGGSSYTPELL CELF_ECOLI 6 6 KVVTIGGGSSYTPELL D908165 6 6 SIVIAGGGSTFTPGIV GLVG_BACSU 7 7 SVVVAGGGSTFTPGIV GLVG_ECOLI 5 5 KIAYIGGGSQGWARSL LPLD_BACSU 11 11 KITFIGAGSTIFVKNI AGAL_ECOLI 6 6 GLHYDRLASE42 Length of motif = 17 Motif number = 2 Glycosyl hydrolase family 4 motif II - 1 PCODE ST INT ALKDADFVTTQFRVGLL CELF_BACSU 77 55 ALKDADFVTTQLRVGQL CELF_ECOLI 77 55 ALKDADFVTTQLRVGQL D908165 77 55 AFTDVDFVMAHIRVGKY GLVG_BACSU 76 53 AFSDVDFVMAHIRVGKY GLVG_ECOLI 74 53 ALSAADIVIISILPGSL LPLD_BACSU 76 49 ALEDADFVVVAFQIGGY AGAL_ECOLI 75 53 GLHYDRLASE43 Length of motif = 14 Motif number = 3 Glycosyl hydrolase family 4 motif III - 1 PCODE ST INT KDERIPLKYGVIGQ CELF_BACSU 98 4 LDERIPLSHGYLGQ CELF_ECOLI 98 4 LDERIPLSHGYLGQ D908165 98 4 LDEQIPLKYGVVGQ GLVG_BACSU 97 4 LDEKIPLRHGVVGQ GLVG_ECOLI 95 4 VDVHLPERCGIYQS LPLD_BACSU 97 4 TDFEVCKRHGLEQT AGAL_ECOLI 97 5 GLHYDRLASE44 Length of motif = 21 Motif number = 4 Glycosyl hydrolase family 4 motif IV - 1 PCODE ST INT ETNGPGGLFKGLRTIPVILEI CELF_BACSU 112 0 ETNGAGGLFKGLRTIPVIFDI CELF_ECOLI 112 0 ETNGAGGLFKGLRTIPVIFDI D908165 112 0 ETCGPGGIAYGMRSIGGVLEI GLVG_BACSU 111 0 ETCGPGGIAYGMRSIGGVLEL GLVG_ECOLI 109 0 DTVGPGGIIRGLRAVPIFAEI LPLD_BACSU 113 2 DTLGPGGIMRALRTIPHLWQI AGAL_ECOLI 113 2 GLHYDRLASE45 Length of motif = 18 Motif number = 5 Glycosyl hydrolase family 4 motif V - 1 PCODE ST INT PNAWLVNFTNPAGMVTEA CELF_BACSU 141 8 PNAWVINFTNPAGMVTEA CELF_ECOLI 141 8 PNAWVINFTNPAGMVTEA D908165 141 8 PDAWMLNYSNPAAIVAEA GLVG_BACSU 140 8 PNAWMLNYSNPAAIVAEA GLVG_ECOLI 138 8 PESWVINYTNPMYVCTRV LPLD_BACSU 142 8 PDATMLNYVNPMAMNTWA AGAL_ECOLI 142 8 GLHYDRLASE46 Length of motif = 12 Motif number = 6 Glycosyl hydrolase family 4 motif VI - 1 PCODE ST INT KVVGLCNVPIGI CELF_BACSU 167 8 RFIGVCNIPIGM CELF_ECOLI 167 8 RFIGVCNIPIGM D908165 167 8 KILNICDMPVGI GLVG_BACSU 166 8 KILNICDMPIGI GLVG_ECOLI 164 8 KAIGCCHEVFGT LPLD_BACSU 168 8 KQVGLCHSVQGT AGAL_ECOLI 168 8 GLHYDRLASE48 Length of motif = 13 Motif number = 7 Glycosyl hydrolase family 4 motif VII - 1 PCODE ST INT VEVQFAGLNHMVF CELF_BACSU 193 14 LSIDLFGLNHMVF CELF_ECOLI 194 15 LSIDLFGLNHMVF D908165 194 15 MKVRYYGLNHFGW GLVG_BACSU 193 15 MRVRYYGLNHWWS GLVG_ECOLI 191 15 IRVNVLGINHFTW LPLD_BACSU 201 21 LRYRCAGINHMAF AGAL_ECOLI 194 14 FINAL MOTIF SETS GLHYDRLASE41 Length of motif = 16 Motif number = 1 Glycosyl hydrolase family 4 motif I - 2 PCODE ST INT SIVIAGGGSTFTPGIV GLVG_BACSU 7 7 SVVVAGGGSTFTPGIV GLVG_ECOLI 5 5 SILIAGGGSTFTPGII MALH_FUSMR 5 5 KIVTIGGGSSYTPELV CELF_BACSU 6 6 KVVTIGGGSSYTPELL CELF_ECOLI 6 6 KITFIGAGSTIFAKNV AGAL_BACSU 3 3 KITFIGAGSTIFVKNI AGAL_ECOLI 6 6 KIAYIGGGSQGWARSL LPLD_BACSU 11 11 GLHYDRLASE42 Length of motif = 17 Motif number = 2 Glycosyl hydrolase family 4 motif II - 2 PCODE ST INT AFTDVDFVMAHIRVGKY GLVG_BACSU 76 53 AFSDVDFVMAHIRVGKY GLVG_ECOLI 74 53 AFTDIDFVMAHIRVGKY MALH_FUSMR 74 53 ALKDADFVTTQFRVGLL CELF_BACSU 77 55 ALKDADFVTTQLRVGQL CELF_ECOLI 77 55 ALQNAGYVINAIQVGGY AGAL_BACSU 72 53 ALEDADFVVVAFQIGGY AGAL_ECOLI 75 53 ALSAADIVIISILPGSL LPLD_BACSU 76 49 GLHYDRLASE43 Length of motif = 14 Motif number = 3 Glycosyl hydrolase family 4 motif III - 2 PCODE ST INT LDEQIPLKYGVVGQ GLVG_BACSU 97 4 LDEKIPLRHGVVGQ GLVG_ECOLI 95 4 LDEKIPLRHGVVGQ MALH_FUSMR 95 4 KDERIPLKYGVIGQ CELF_BACSU 98 4 LDERIPLSHGYLGQ CELF_ECOLI 98 4 IDFEIPKRYGLRQT AGAL_BACSU 94 5 TDFEVCKRHGLEQT AGAL_ECOLI 97 5 VDVHLPERCGIYQS LPLD_BACSU 97 4 GLHYDRLASE44 Length of motif = 21 Motif number = 4 Glycosyl hydrolase family 4 motif IV - 2 PCODE ST INT ETCGPGGIAYGMRSIGGVLEI GLVG_BACSU 111 0 ETCGPGGIAYGMRSIGGVLEL GLVG_ECOLI 109 0 ETCGPGGIAYGMRSIGGVIGL MALH_FUSMR 109 0 ETNGPGGLFKGLRTIPVILEI CELF_BACSU 112 0 ETNGAGGLFKGLRTIPVIFDI CELF_ECOLI 112 0 DTVGIGGIFRSLRTIPVLFDI AGAL_BACSU 110 2 DTLGPGGIMRALRTIPHLWQI AGAL_ECOLI 113 2 DTVGPGGIIRGLRAVPIFAEI LPLD_BACSU 113 2 GLHYDRLASE45 Length of motif = 18 Motif number = 5 Glycosyl hydrolase family 4 motif V - 2 PCODE ST INT PDAWMLNYSNPAAIVAEA GLVG_BACSU 140 8 PNAWMLNYSNPAAIVAEA GLVG_ECOLI 138 8 PNAWMLNYSNPAAIVAEA MALH_FUSMR 138 8 PNAWLVNFTNPAGMVTEA CELF_BACSU 141 8 PNAWVINFTNPAGMVTEA CELF_ECOLI 141 8 PDAWFLNYTNPMATLTGA AGAL_BACSU 139 8 PDATMLNYVNPMAMNTWA AGAL_ECOLI 142 8 PESWVINYTNPMSVCTRV LPLD_BACSU 142 8 GLHYDRLASE46 Length of motif = 12 Motif number = 6 Glycosyl hydrolase family 4 motif VI - 2 PCODE ST INT KILNICDMPVGI GLVG_BACSU 166 8 KILNICDMPIGI GLVG_ECOLI 164 8 KVLNICDMPIGI MALH_FUSMR 164 8 KVVGLCNVPIGI CELF_BACSU 167 8 RFIGVCNIPIGM CELF_ECOLI 167 8 KTIGLCHSVQVC AGAL_BACSU 164 7 KQVGLCHSVQGT AGAL_ECOLI 168 8 KAIGCCHEVFGT LPLD_BACSU 168 8 GLHYDRLASE47 Length of motif = 13 Motif number = 7 Glycosyl hydrolase family 4 motif VII - 2 PCODE ST INT MKVRYYGLNHFGW GLVG_BACSU 193 15 MRVRYYGLNHWWS GLVG_ECOLI 191 15 MDIMYYGLNHFGW MALH_FUSMR 191 15 VEVQFAGLNHMVF CELF_BACSU 193 14 LSIDLFGLNHMVF CELF_ECOLI 194 15 IEERIAGINHMAW AGAL_BACSU 190 14 LRYRCAGINHMAF AGAL_ECOLI 194 14 IRVNVLGINHFTW LPLD_BACSU 201 21

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